5 results match your criteria Skeletal System - Toddler

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Asfotase alfa for infants and young children with hypophosphatasia: 7 year outcomes of a single-arm, open-label, phase 2 extension trial.

Lancet Diabetes Endocrinol 2018 Dec 14. Epub 2018 Dec 14.

Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO, USA.

Background: Our previous phase 2, open-label study of 11 infants and young children with life-threatening perinatal or infantile hypophosphatasia showed 1 year safety and efficacy of asfotase alfa, an enzyme replacement therapy. We aimed to report the long-term outcomes over approximately 7 years of treatment.

Methods: We did a prespecified, end of study, 7 year follow-up of our single-arm, open-label, phase 2 trial in which children aged 3 years or younger with life-threatening perinatal or infantile hypophosphatasia were recruited from ten hospitals (six in the USA, two in the UK, one in Canada, and one in the United Arab Emirates). Read More

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http://dx.doi.org/10.1016/S2213-8587(18)30307-3DOI Listing
December 2018

A Toddler With Nasal Congestion and a Limp.

JAMA Otolaryngol Head Neck Surg 2017 02;143(2):191-192

Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland5Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.

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http://dx.doi.org/10.1001/jamaoto.2016.2392DOI Listing
February 2017
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Brachial plexopathy and nonaccidental injury: role of the neurologist.

J Child Neurol 2010 May;25(5):620-2

Department of Neurology, Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA.

Child neurologists must remain vigilant to the possibility of nonaccidental injury. Just as clinicians have become accustomed to considering potential abuse or neglect in children presenting with a head injury or skeletal trauma, physical abuse must also be considered when children present with lesions at other sites of the neuraxis, as illustrated by this child's brachial plexopathy. Key elements from the history can assist clinicians in differentiating accidental events from nonaccidental injuries secondary to abuse or neglect. Read More

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http://dx.doi.org/10.1177/0883073809359808DOI Listing
May 2010
4 Reads

Postural behavior in children born preterm.

Neural Plast 2005 ;12(2-3):175-82; discussion 263-72

Oslo University College, Health Sciences, Physiotherapy Programme, 0130 Oslo, Norway.

The present paper presents clinical and neurophysiological data of postural behavior in preterm children without CP. Clinical follow-up studies of preterm infants until toddler and school age have reported that low-risk preterm infants may have atypical postural behavior in terms of reduced amount of rotation during crawling, delayed dynamic balance, delayed onset of and a poor quality of early walking behavior. At school age, dysfunctions such as problems in standing on one leg and poor hopping are reported. Read More

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http://downloads.hindawi.com/journals/np/2005/573752.pdf
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2565451PMC
September 2005
6 Reads

Hereditary neuropathy with liability to pressure palsies (HNPP) in a toddler presenting with toe-walking, pain and stiffness.

Neuromuscul Disord 2003 Dec;13(10):827-9

Department of Child Neurology, Hospital for Children and Adolescents, University of Helsinki, Helsinki University Central Hospital (HUCH), 00029 Helsinki, Finland.

The typical clinical presentation of hereditary neuropathy with liability to pressure palsies is an adult-onset recurrent, painless monoparesis. Electrophysiological abnormalities--decreased nerve conduction velocities and delayed distal latencies--can be detected even in asymptomatic patients. We describe a toddler, who presented with asymmetric toe walking, painful cramps and stiffness in the legs. Read More

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http://www.hindawi.com/journals/cripe/aip/382657.pdf
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December 2003
3 Reads
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