11,798 results match your criteria Skeletal System - Adult


Synchronous correction in secondary cleft deformities: a prospective cohort study.

Minerva Stomatol 2020 Jun 2. Epub 2020 Jun 2.

Department of Oral and Maxillofacial Surgery SRM Dental College and Hospital, Ramapuram, Chennai, India.

Background: Patients with cleft lip and palate deformities undergo multiple surgical procedures from infancy till adolescence. We hypothesized that combining these surgical procedures might offer a better quality of life without compromising on surgical outcomes.

Subjects & Methods: A prospective cohort study was conducted at our centre including all adult patients who reported to us for the correction of secondary cleft deformities. Read More

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http://dx.doi.org/10.23736/S0026-4970.20.04302-2DOI Listing

A developmental staging system and musculoskeletal development sequence of the Common Musk turtle (Sternotherus odoratus).

Dev Dyn 2020 Jun 3. Epub 2020 Jun 3.

Department of Earth and Planetary Science , Peabody Museum of Natural History, Yale University.

Background: The extremely derived body plan of turtles has sparked a great interest in studying their developmental biology. Here, we describe the embryonic development of the Stinkpot, or Common musk turtle (Sternotherus odoratus), a small aquatic turtle from the family Kinosternidae.

Results: We identify 20 distinct developmental stages, some comparable to stages described by previous studies on other turtles and some in between these, improving the resolution of the generalities of turtle development. Read More

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http://dx.doi.org/10.1002/dvdy.210DOI Listing

Novel model of restricted mobility induced osteopenia in zebrafish.

J Fish Biol 2020 May 8. Epub 2020 May 8.

The Musculoskeletal Genetics Laboratory, The Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel.

Immobilization, such as prolonged bed rest, is a risk factor for bone loss in humans. Motivated by the emerging utility of zebrafish (Danio rerio) as an animal of choice for the study of musculoskeletal disease, here we report a model of restricted-mobility-induced osteopenia in adult zebrafish. Aquatic tanks with small cubical compartments to restrict the movement and locomotion of single fish were designed and fabricated for this study. Read More

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http://dx.doi.org/10.1111/jfb.14369DOI Listing
May 2020
1.658 Impact Factor

3D cephalometry on reduced FOV CBCT: skeletal class assessment through AF-BF on Frankfurt plane-validity and reliability through comparison with 2D measurements.

Eur Radiol 2020 May 7. Epub 2020 May 7.

Department of Medicine, Surgery and Dentistry Department of Orthodontics, Università degli Studi di Milano - Fondazione IRCCS Cà Granda, Milan, Italy.

Objectives: To test the validity of a novel protocol for 3D sagittal jaw discrepancy assessment (skeletal class determination) through comparison with common 2D indexes by the use of reduced FOV (10 × 10) CBCT which shows at least from the Frankfurt plane to the B point vertically, and from the most anterior between A and B point to Po point horizontally.

Methods: A sample of CBCT scans of 109 adult patients (46 females; 63 males; mean age 30 years ± 11.6) equally distributed between I, II and III class was selected. Read More

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http://dx.doi.org/10.1007/s00330-020-06905-7DOI Listing
May 2020
4.014 Impact Factor

Co-Transplantation of Bone Marrow-MSCs and Myogenic Stem/Progenitor Cells from Adult Donors Improves Muscle Function of Patients with Duchenne Muscular Dystrophy.

Cells 2020 Apr 30;9(5). Epub 2020 Apr 30.

Institute of Human Genetics of the Polish Academy of Sciences, Department of Reproductive Biology and Stem Cells, 60-479 Poznan, Poland.

Duchenne muscular dystrophy (DMD) is a genetic disorder associated with a progressive deficiency of dystrophin that leads to skeletal muscle degeneration. In this study, we tested the hypothesis that a co-transplantation of two stem/progenitor cell populations, namely bone marrow-derived mesenchymal stem cells (BM-MSCs) and skeletal muscle-derived stem/progenitor cells (SM-SPCs), directly into the dystrophic muscle can improve the skeletal muscle function of DMD patients. Three patients diagnosed with DMD, confirmed by the dystrophin gene mutation, were enrolled into a study approved by the local Bioethics Committee (no. Read More

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http://dx.doi.org/10.3390/cells9051119DOI Listing

Histomorphometric analysis of the variability of the human skeleton: Forensic implications.

Leg Med (Tokyo) 2020 Apr 23;45:101711. Epub 2020 Apr 23.

LABANOF (Laboratorio di Antropologia e Odontologia Forense) Dipartimento di Scienze Biomediche per la Salute, via Mangiagalli 37, 20133, Università degli Studi di Milano, Italy.

In the last decades, the histomorphometric analysis of bone tissue has been utilized to develop equations for species discrimination of fragmentary bone. Although this technique showed promising results, its main limitation concerns the lack of knowledge on the histomorphometric variability which may exist between different bones of the skeleton. In a previous study, we demonstrated a significant histomorphological variability in different bones of the same individual and even in different sections of the same bone. Read More

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http://dx.doi.org/10.1016/j.legalmed.2020.101711DOI Listing

Analysis of DNA methylation profiles during sheep skeletal muscle development using whole-genome bisulfite sequencing.

BMC Genomics 2020 Apr 29;21(1):327. Epub 2020 Apr 29.

Jiangsu Livestock Embryo Engineering Laboratory, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, 210095, China.

Background: DNA methylation is an epigenetic regulatory form that plays an important role in regulating the gene expression and the tissues development.. However, DNA methylation regulators involved in sheep muscle development remain unclear. Read More

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http://dx.doi.org/10.1186/s12864-020-6751-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191724PMC

Expression of Nik-related kinase in smooth muscle cells attenuates vascular inflammation and intimal hyperplasia.

Aging (Albany NY) 2020 Apr 24;12(8):7511-7533. Epub 2020 Apr 24.

Institute of Cellular and System Medicine, National Health Research Institutes, Zhunan 350, Taiwan.

Inflammation of the vascular microenvironment modulates distinct types of vascular cells, and plays important roles in promoting atherosclerosis, stenosis/restenosis, and vascular-related diseases. Nik-related kinase (Nrk), a member of the Ste20-type kinase family, has been reported to be selectively expressed in embryonic skeletal muscle. However, whether Nrk is expressed in adult vascular smooth muscle, and if it influences intimal hyperplasia is unclear. Read More

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http://dx.doi.org/10.18632/aging.103104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202544PMC

Blood flow restriction exercise stimulates mobilization of hematopoietic stem/progenitor cells and increases the circulating ACE2 levels in healthy adults.

J Appl Physiol (1985) 2020 May 23;128(5):1423-1431. Epub 2020 Apr 23.

Department of Pharmaceutical Sciences, College of Health Professions, North Dakota State University, Fargo, North Dakota.

Adult CD34 hematopoietic stem/progenitor cells (HSPC) in the systemic circulation are bone marrow-derived and have the propensity of maintaining cardiovascular health. Activation of angiotensin-converting enzyme-2 (ACE2)-angiotensin-(1-7)-Mas receptor pathway, the vascular protective axis of the renin-angiotensin system (RAS), stimulates vasculogenic functions of HSPCs. In a previous study, exposure to hypoxia increased the expressions of ACE2 and Mas, and stimulated ACE2 shedding. Read More

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http://dx.doi.org/10.1152/japplphysiol.00109.2020DOI Listing

Brain-Derived Acetylcholine Maintains Peak Bone Mass in Adult Female Mice.

J Bone Miner Res 2020 Apr 13. Epub 2020 Apr 13.

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.

Preclinical and clinical data support a role of the sympathetic nervous system in the regulation of bone remodeling, but the contribution of parasympathetic arm of the autonomic nervous system to bone homeostasis remains less studied. In this study, we sought to determine whether acetylcholine (ACh) contributes to the regulation of bone remodeling after peak bone mass acquisition. We show that reduced central ACh synthesis in mice heterozygous for the choline transporter (ChT) leads to a decrease in bone mass in young female mice, thus independently confirming the previously reported beneficial effect of ACh signaling on bone mass accrual. Read More

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http://dx.doi.org/10.1002/jbmr.4024DOI Listing

Factors affecting success in the treatment of proximal ureteral stones larger than 1 cm with extracorporeal shockwave lithotripsy in adult patients.

Urolithiasis 2020 Apr 11. Epub 2020 Apr 11.

Department of Urology, Istanbul Aydin University Medical Faculty, Istanbul, Turkey.

The aim of the study was to analyze the factors predicting success for the treatment of proximal ureteral stones larger than 1 cm with extracorporeal shockwave lithotripsy (SWL) in adult patients. Between January 2014 and December 2018, 480 adult patients in total underwent SWL and data were retrospectively evaluated. Patients with multiple ureteral stones, solitary kidney, congenital abnormality, skeletal system abnormality, history of previous urinary system surgery and SWL, renal insufficiency, patients who could not tolerate SWL and pediatric patients were excluded from the study. Read More

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http://dx.doi.org/10.1007/s00240-020-01186-7DOI Listing

The psoas muscle index distribution and influence of outcomes in an Asian adult trauma population: an alternative indicator for sarcopenia of acute diseases.

Eur J Trauma Emerg Surg 2020 Apr 10. Epub 2020 Apr 10.

Division of Trauma and Emergency Surgery, Department of Surgery, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan.

Background: Sarcopenia has been shown to be an independent negative predictor in various diseases. The measurement of pre-defined criteria of skeletal muscle in patients with acute disease is usually unavailable. Therefore, we evaluate the psoas muscle area based on computed tomography (CT) imaging as an alternative for sarcopenia in an Asian trauma population. Read More

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http://dx.doi.org/10.1007/s00068-020-01360-xDOI Listing

The Effect of Vitamin D Supplementation on Serum and Muscle Irisin Levels, and FNDC5 Expression in Diabetic Rats.

Rep Biochem Mol Biol 2019 Oct;8(3):236-243

Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.

Background: Diabetes mellitus and metabolic disorders are a major burden on the healthcare system. Irisin is a novel myokine reported to have beneficial effects on glucose and lipid metabolism. Vitamin D deficiency has been implicated in the development of diabetes and hold a critical role in diabetes-related complications. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103079PMC
October 2019

A "Neuromuscular Look" to sarcopenia: Is it a movement disorder?

J Rehabil Med 2020 04 14;52(4):jrm00042. Epub 2020 Apr 14.

Physical and Rehabilitation Medicine, Hacettepe University Medical School, Ankara, Turkey.

Objective: Impairment of physical function is the main determinant of morbidity/mortality in sarcopenia and frailty. Physical function tests are performed by the movement around the joints, and skeletal muscles are the main generators of the forces required to perform these functional tasks. However, the central nervous system, which initiates and coordinates muscle movements, controls the magnitude and temporal parameters of muscle forces. Read More

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http://dx.doi.org/10.2340/16501977-2672DOI Listing

Central nervous system and peripheral cell labeling by vascular endothelial cadherin-driven lineage tracing in adult mice.

Neural Regen Res 2020 Oct;15(10):1856-1866

Biomolecular Ph.D. Program, Boise State University; Department of Biological Sciences, Boise State University, Boise, ID, USA.

Understanding the contribution of endothelial cells to the progenitor pools of adult tissues has the potential to inform therapies for human disease. To address whether endothelial cells transdifferentiate into non-vascular cell types, we performed cell lineage tracing analysis using transgenic mice engineered to express a fluorescent marker following activation by tamoxifen in vascular endothelial cadherin promoter-expressing cells (VEcad-CreER; B6 Cg-Gt(ROSA)26Sort). Activation of target-cell labeling following 1. Read More

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http://dx.doi.org/10.4103/1673-5374.280317DOI Listing
October 2020

Comprehensive analysis of skeletal muscle- and bone-derived mesenchymal stem/stromal cells in patients with osteoarthritis and femoral neck fracture.

Stem Cell Res Ther 2020 Apr 3;11(1):146. Epub 2020 Apr 3.

University of Ljubljana, Faculty of Pharmacy, Chair of Clinical Biochemistry, Askerceva 7, 1000, Ljubljana, Slovenia.

Background: Mesenchymal stem/stromal cells (MSCs) can replenish the aged cells of the musculoskeletal system in adult life. Stem cell exhaustion and decrease in their regenerative potential have been suggested to be hallmarks of aging. Here, we investigated whether muscle- and bone-derived MSCs of patients with osteoarthritis and osteoporosis are affected by this exhaustion, compared to healthy donors. Read More

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http://dx.doi.org/10.1186/s13287-020-01657-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118858PMC

Adaptive shifts in gene regulation underlie a developmental delay in thermogenesis in high-altitude deer mice.

Mol Biol Evol 2020 Apr 3. Epub 2020 Apr 3.

Division of Biological Sciences, University of Montana, 32 Campus Drive, Missoula, MT.

Aerobic performance is tied to fitness as it influences an animal's ability to find food, escape predators, or survive extreme conditions. At high altitude, where low O2 availability and persistent cold prevail, maximum metabolic heat production (thermogenesis) is an aerobic performance trait that is closely linked to survival. Understanding how thermogenesis evolves to enhance survival at high altitude will yield insight into the links between physiology, performance, and fitness. Read More

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http://dx.doi.org/10.1093/molbev/msaa086DOI Listing
April 2020
9.105 Impact Factor

Orthodontic management of a non-syndromic patient with concomitant bimaxillary hypohyperdontia: a case report.

Dental Press J Orthod 2020 Jan-Feb;25(1):36-46

Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Department of Orthodontics (Okayama, Japan).

Introduction: Tooth agenesis is one of the most common dental anomalies; however, the concomitant occurrence of opposite dental numerical variation of hypohyperdontia is extremely rare.

Objective: To report the successful orthodontic management of a patient with non-syndromic concomitant bilateral agenesis of mandibular canines and two midline inverted supernumerary maxillary teeth.

Case Report: 21-year-old female patient with a chief complaint of protrusive right maxillary central incisor. Read More

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http://dx.doi.org/10.1590/2177-6709.25.1.036-046.oarDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077940PMC

New insights into Wnt signaling alterations in amyotrophic lateral sclerosis: a potential therapeutic target?

Neural Regen Res 2020 Sep;15(9):1580-1589

Laboratory of Molecular Neurology, Hospital Nacional de Parapléjicos (HNP), Toledo, Spain.

Amyotrophic lateral sclerosis is a fatal neurodegenerative disorder characterized by upper and lower motor neuron degeneration, which leads to progressive paralysis of skeletal muscles and, ultimately, respiratory failure between 2-5 years after symptom onset. Unfortunately, currently accepted treatments for amyotrophic lateral sclerosis are extremely scarce and only provide modest benefit. As a consequence, a great effort is being done by the scientific community in order to achieve a better understanding of the different molecular and cellular processes that influence the progression and/or outcome of this neuropathological condition and, therefore, unravel new potential targets for therapeutic intervention. Read More

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http://dx.doi.org/10.4103/1673-5374.276320DOI Listing
September 2020

Novel strategies for expansion of tooth epithelial stem cells and ameloblast generation.

Sci Rep 2020 Mar 18;10(1):4963. Epub 2020 Mar 18.

Research Program in Developmental Biology, Institute of Biotechnology, University of Helsinki, Helsinki, Finland.

Enamel is secreted by ameloblasts derived from tooth epithelial stem cells (SCs). Humans cannot repair or regenerate enamel, due to early loss of tooth epithelial SCs. Contrarily in the mouse incisors, epithelial SCs are maintained throughout life and endlessly generate ameloblasts, and thus enamel. Read More

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http://dx.doi.org/10.1038/s41598-020-60708-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7080756PMC

Identification and Characterization of a Non-muscular Myostatin in the Nile Tilapia.

Front Endocrinol (Lausanne) 2020 28;11:94. Epub 2020 Feb 28.

Department of Poultry and Aquaculture, Institute of Animal Science, Agricultural Research Organization, Rishon LeTsiyon, Israel.

The growth and differentiation factor Myostatin (MSTN, also known as GDF8) negatively regulates skeletal muscle development and growth in vertebrates. Most fish genomes contain two or more genes, which are expressed in muscle and other tissues. Yet, in the genome of Nile tilapia (), which is one of the world's most important aquaculture fish species, only one gene has previously been identified. Read More

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http://dx.doi.org/10.3389/fendo.2020.00094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059221PMC
February 2020

Risk stratification for central conventional chondrosarcoma of bone: A novel system predicting risk of metastasis and death in the Cancer Registry of Norway cohort.

J Surg Oncol 2020 Jun 5;121(7):1115-1125. Epub 2020 Mar 5.

Division of Orthopedic Surgery, Oslo University Hospital, Oslo, Norway.

Background And Objectives: Interobserver variability in histological grading of central conventional chondrosarcoma (CCCS) limits the quality of patient information and research progression. We aim to quantify known and new prognostic variables and propose a risk stratification model.

Method: We selected 149 cases from the Cancer Registry of Norway. Read More

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http://dx.doi.org/10.1002/jso.25883DOI Listing

Simple Skeletal Muscle Mass Estimation Formulas: What We Can Learn From Them.

Front Endocrinol (Lausanne) 2020 5;11:31. Epub 2020 Feb 5.

Department of Public Health Sciences, Clemson University, Clemson, SC, United States.

One century ago Harris and Benedict published a short report critically examining the relations between body size, body shape, age, and basal metabolic rate. At the time, basal metabolic rate was a vital measurement in diagnosing diseases such as hypothyroidism. Their conclusions and basal metabolic rate prediction formulas still resonate today. Read More

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http://dx.doi.org/10.3389/fendo.2020.00031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7012897PMC
February 2020

USP7-dependent control of myogenin stability is required for terminal differentiation in skeletal muscle progenitors.

FEBS J 2020 Mar 1. Epub 2020 Mar 1.

Laboratory of Tissue Repair and Adult Stem Cells, Molecular and Cell Biology Department, Faculty of Biological Sciences, Pontificia Universidad Católica de Chile, Santiago, Chile.

Satellite cells (SCs) are myogenic progenitors responsible for skeletal muscle regeneration and maintenance. Upon activation, SCs enter a phase of robust proliferation followed by terminal differentiation. Underlying this myogenic progression, the sequential expression of muscle regulatory transcription factors (MRFs) and the downregulation of transcription factor paired box gene 7 (Pax7) are key steps regulating SC fate. Read More

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http://dx.doi.org/10.1111/febs.15269DOI Listing

CORP: Using transgenic mice to study skeletal muscle physiology.

J Appl Physiol (1985) 2020 May 27;128(5):1227-1239. Epub 2020 Feb 27.

Department of Physiology, College of Medicine, University of Kentucky, Lexington, Kentucky.

The development of tissue-specific inducible transgenic mice has provided a powerful tool to study gene function and cell biology in almost any tissue of interest at any given time within the animal's life. The purpose of this review is to describe how to use two different inducible transgenic systems, the Cre-loxP system and the Tet-ON/OFF system, that can be used to study skeletal muscle physiology. Myofiber- and satellite cell-specific Cre-loxP transgenic mice are described as is how these mice can be used to knockout a gene of interest or to deplete satellite cells in adult skeletal muscle, respectively. Read More

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http://dx.doi.org/10.1152/japplphysiol.00021.2020DOI Listing

Development and thyroid hormone dependence of skeletal muscle mitochondrial function towards birth.

J Physiol 2020 Feb 22. Epub 2020 Feb 22.

Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, CB2 3EG, UK.

Key Points: Skeletal muscle energy requirements increase at birth but little is known regarding the development of mitochondria that provide most of the cellular energy as ATP. Thyroid hormones are known regulators of adult metabolism and are important in driving several aspects of fetal development, including muscle fibre differentiation. Mitochondrial density and the abundance of mitochondrial membrane proteins in skeletal muscle increased during late gestation. Read More

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http://dx.doi.org/10.1113/JP279194DOI Listing
February 2020

Prune belly syndrome in surviving males can be caused by Hemizygous missense mutations in the X-linked Filamin A gene.

BMC Med Genet 2020 02 21;21(1):38. Epub 2020 Feb 21.

Department of Urology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX, 75390, USA.

Background: Prune belly syndrome (PBS) is a rare, multi-system congenital myopathy primarily affecting males that is poorly described genetically. Phenotypically, its morbidity spans from mild to lethal, however, all isolated PBS cases manifest three cardinal pathological features: 1) wrinkled flaccid ventral abdominal wall with skeletal muscle deficiency, 2) urinary tract dilation with poorly contractile smooth muscle, and 3) intra-abdominal undescended testes. Despite evidence for a genetic basis, previously reported PBS autosomal candidate genes only account for one consanguineous family and single cases. Read More

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http://dx.doi.org/10.1186/s12881-020-0973-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7035669PMC
February 2020

Substantial tumor regression in prostate cancer patient with extensive skeletal metastases upon Immunotherapy (APCEDEN): A case report.

Medicine (Baltimore) 2020 Feb;99(8):e18889

APAC Biotech Pvt Ltd, Gurgaon, Haryana, India.

Rationale: Prostate cancer along with colorectal and lung cancers accounts for 42% of cancer cases in men globally. It is the first cancer indication for which the use of active immunotherapy, Sipuleucel-T (Provenge) was granted by the FDA in 2010. This study presents a case of prostate carcinoma and the tumour remission observed after administration of a personalised Dendritic cell vaccine (APCEDEN). Read More

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http://dx.doi.org/10.1097/MD.0000000000018889DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034657PMC
February 2020
5.723 Impact Factor

[The application of neuroimaging reconstruction technique in evaluating the relationship between skeletal musculature tumors and nerves nearby].

Zhonghua Yi Xue Za Zhi 2020 Feb;100(5):382-386

Department of Radiology, Peking University Shougang Hospital, Beijing 100041, China.

To analyze the relationship between tumors of the musculoskeletal system and adjacent nerves by reconstructing images of peripheral nerves, and explore its value in surgical treatment. From May 2016 to April 2019, a total of 27 patients were collected in Department of Imaging,Shougang Hospital, who were with skeletal muscle system tumors, including 15 primary soft tissue tumors, 9 primary bone tumors, 3 metastatic tumors, all of them were closely related to nerves. There were 17 males and 10 females, aged 13-67 years, with an average age of 34 years. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2020.05.013DOI Listing
February 2020

Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) Sr/Sr isotope data from scythian Iron age barrows in Altai, Russia.

Data Brief 2020 Apr 19;29:105026. Epub 2019 Dec 19.

Archaeological Research Laboratory, Department of Archaeology and Classical Studies Stockholm University, Lilla Frescativägen 7, 114 18 Stockholm, Sweden.

This paper reports LA-ICP-MS Sr/Sr isotopic data collected from archaeological human remains uncovered in Manzherok region, Altai Republic, Russian Federation ("Mobility of nomads in central Asia: chronology and Sr/Sr isotope evidence from the Pazyryk barrows of northern Altai, Russia" [1]. The skeletal remains derive from Scythian barrows dated to 6th - 3rd century BC located at Chultukov Log 1 cemetery. The Chultukov Log cemetery, located approximately 470km south of Novosibirsk, is considered the biggest nomadic burial ground in the Upper Altai and the Sayan Mountains. Read More

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http://dx.doi.org/10.1016/j.dib.2019.105026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016223PMC

A new process to measure postural sway using a Kinect depth camera during a Sensory Organisation Test.

PLoS One 2020 5;15(2):e0227485. Epub 2020 Feb 5.

Department of Sport and Exercise Sciences, Manchester Metropolitan University, Manchester, United Kingdom.

Posturography provides quantitative, objective measurements of human balance and postural control for research and clinical use. However, it usually requires access to specialist equipment to measure ground reaction forces, which are not widely available in practice, due to their size or cost. In this study, we propose an alternative approach to posturography. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0227485PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7001893PMC

GABA in developing rat skeletal muscle and motor neurons.

Protoplasma 2020 May 3;257(3):1009-1015. Epub 2020 Feb 3.

Kazan Institute of Biochemistry and Biophysics, FRC Kazan Scientific Center, Russian Academy of Sciences, Kazan, 420111, Russia.

In recent years, considerable evidence is accumulated pointing to participation of gamma-aminobutyric acid (GABA) in intercellular signaling in the peripheral nervous system, including, in particular, neuromuscular transmission. However, where in the neuromuscular synapse GABA is synthesized remains not quite clear. We used histochemical methods to detect GABA and L-glutamate decarboxylase (GAD) in developing skeletal muscle fibers and in cultured motor neurons. Read More

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http://dx.doi.org/10.1007/s00709-020-01485-1DOI Listing

Antidiabetic and antiosteoporotic pharmacotherapies for prevention and treatment of type 2 diabetes-induced bone disease: protocol for two network meta-analyses.

BMJ Open 2020 Feb 2;10(1):e034741. Epub 2020 Feb 2.

Division of Orthopedic Surgery, Department of Surgery, McMaster University, Hamilton, Ontario, Canada.

Introduction: Patients with type 2 diabetes mellitus (T2DM) are at risk for a variety of severe debilitating effects. One of the most serious complications experienced by patients with T2DM are skeletal diseases caused by changes in the bone microenvironment. As a result, patients with T2DM are at risk for higher prevalence of fragility fractures. Read More

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http://dx.doi.org/10.1136/bmjopen-2019-034741DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7045154PMC
February 2020

Follistatin expression in the central nervous system of the adult rat.

J Chem Neuroanat 2020 Apr 31;105:101753. Epub 2020 Jan 31.

Department of Organ & Tissue Anatomy, Japan. Electronic address:

Follistatin was initially cloned as a monomeric polypeptide that inhibits the release of follicle-stimulating hormone. Although follistatin also plays pivotal roles in skeletal muscle hypertrophy and immunoregulation in the epididymis, little information is available regarding follistatin function in the adult central nervous system (CNS). Hence, we investigated follistatin expression in the adult rat CNS using immunohistochemistry. Read More

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http://dx.doi.org/10.1016/j.jchemneu.2020.101753DOI Listing

Bone health in adolescents with idiopathic scoliosis.

Bone Joint J 2020 Feb;102-B(2):268-272

Department of Clinical Sciences, Intervention and Technology (CLINTEC), Karolinska Institutet, Stockholm, Sweden.

Aims: Idiopathic scoliosis is the most common spinal deformity in adolescents and children. The aetiology of the disease remains unknown. Previous studies have shown a lower bone mineral density in individuals with idiopathic scoliosis, which may contribute to the causation. Read More

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http://dx.doi.org/10.1302/0301-620X.102B2.BJJ-2019-1016.R1DOI Listing
February 2020

Physical exercise rectifies CUMS-induced aberrant regional homogeneity in mice accompanied by the adjustment of skeletal muscle PGC-1a/IDO1 signals and hippocampal function.

Behav Brain Res 2020 Apr 30;383:112516. Epub 2020 Jan 30.

School of Fundamental Medical Science, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China. Electronic address:

Background: Depression is a debilitating condition with a profound influence on quality of life for millions of people globally. Physical exercise has been broadly recognized for its therapeutic effects on depression, but the mechanisms that underlie its benefits remain unknown. In the study, we investigated whether the physical exercise of could be a protection from stress-induced depression and its impact on the brain activity of Regional Homogeneity (ReHo) in mice. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112516DOI Listing

Ascorbate and Iron Are Required for the Specification and Long-Term Self-Renewal of Human Skeletal Mesenchymal Stromal Cells.

Stem Cell Reports 2020 Feb 30;14(2):210-225. Epub 2020 Jan 30.

State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, 1 Beichen West Road, Chaoyang District, Beijing 100101, China; Institute of Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China; University of Chinese Academy of Sciences, Beijing, China. Electronic address:

The effects of ascorbate on adult cell fate specification remain largely unknown. Using our stepwise and chemically defined system to derive lateral mesoderm progenitors from human pluripotent stem cells (hPSCs), we found that ascorbate increased the expression of mesenchymal stromal cell (MSC) markers, purity of MSCs, the long-term self-renewal and osteochondrogenic capacity of hPSC-MSCs in vitro. Moreover, ascorbate promoted MSC specification in an iron-dependent fashion, but not in a redox-dependent manner. Read More

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http://dx.doi.org/10.1016/j.stemcr.2020.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7013236PMC
February 2020

Papillary architecture in the tayra tongue.

Anat Histol Embryol 2020 May 31;49(3):351-358. Epub 2020 Jan 31.

Programa de Pós-Graduação em Saúde e Produção Animal na Amazônia (PPGSPAA), Instituto de Saúde e Produção Animal (ISPA) na Universidade Federal Rural da Amazônia (UFRA), Belem, Brazil.

The tayra (Eira barbara) is a mammal belonging to the Mustelidae family that occurs in all Brazilian biomes. The present work aimed to describe the morphology of the tongue of these specimens highlighting their structures and particularities that will serve as a subsidy to elucidate the anatomy of the same and for comparative studies among other species of domestic and wild animals. Five adult male specimens of E. Read More

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http://dx.doi.org/10.1111/ahe.12536DOI Listing

A recent history of preeclampsia is associated with elevated central pulse wave velocity and muscle sympathetic outflow.

Am J Physiol Heart Circ Physiol 2020 03 31;318(3):H581-H589. Epub 2020 Jan 31.

The John B. Pierce Laboratory, Yale School of Medicine, New Haven, Connecticut.

Preeclampsia is associated with the development of cardiovascular diseases later in life. To investigate this phenomenon, we compared established markers of cardiovascular dysregulation between previously preeclamptic women (PPE; = 12, 13 ± 6 mo postpartum, 34 ± 6 yr) and women who had previously had an uncomplicated pregnancy [control (CTRL); = 12, 15 ± 4 mo postpartum; 29 ± 3 yr]. We hypothesized that PPE would present with elevated arterial stiffness (assessed as central and peripheral pulse wave velocity) and muscle sympathetic nerve activity (MSNA; microneurography) and blunted baroreflex sensitivity (BRS) relative to CTRL. Read More

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http://dx.doi.org/10.1152/ajpheart.00578.2019DOI Listing

Fanconi anemia: a single center experience of a large cohort.

Turk J Pediatr 2019 ;61(4):477-484

Divisions of Pediatric Hematology, Hacettepe University Faculty of Medicine, Ankara.

Kesici S, Ünal Ş, Kuşkonmaz B, Aytaç S, Çetin M, Gümrük F. Fanconi anemia: a single center experience of a large cohort. Turk J Pediatr 2019; 61: 477-484. Read More

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http://dx.doi.org/10.24953/turkjped.2019.04.002DOI Listing

Implementation of a 24-Hour Teleradiology Service for Cruise Ships: A Pilot Study.

AJR Am J Roentgenol 2020 04 28;214(4):754-760. Epub 2020 Jan 28.

Department of Diagnostic and Interventional Radiology and Nuclear Medicine, University Hospital Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.

The purpose of this study was to introduce a 24-hour teleradiology service for cruise ships as a novel concept in maritime telemedicine. One cruise ship equipped with a mobile radiography unit and digital storage imaging plates was involved in this pilot study. Radiographs were transmitted via satellite internet to a tertiary hospital on shore for image interpretation by expert radiologists. Read More

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http://dx.doi.org/10.2214/AJR.19.21794DOI Listing

The condition of skeletal system in pupils with hearing impairment

Wiad Lek 2019 Oct;72(10):1912-1916

Ukrainian Medical Stomatological Academy, Poltava, Ukraine

Introduction: Pathogenic link of dentofacial abnormalities with posture disturbance and vertebra deformation causes interest in researchers, because the problem of the disorder of skeletal system has an important role. Orthodontic correction of dentofacial abnormalities without treatment of skeletal apparatus is incorrect and it leads to the large number of relapses and complications and also including temporo-mandibular joint. The aim of the research was to study correlation between injuries of hard tissues of teeth, posture disorders, bite abnormalities (malocclusion) in schoolchildren with hearing disorders. Read More

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October 2019

Ontogenetic shape changes in the pelvis of the Greater Rhea (Aves, Palaeognathae) and their relationships with cursorial locomotion: a geometric morphometric approach.

J Anat 2020 Jun 23;236(6):1137-1145. Epub 2020 Jan 23.

CONICET, Buenos Aires, Argentina.

Knowledge of the ontogenetic pattern of morphological features is essential to improve biological interpretations. The study of morphological features of the pelvic girdle and hind limb apparatus throughout growth is an excellent approach to understand how the skeletal morphology and muscles are interrelated during growth in a bird with a specialized mode of locomotion. The Greater Rhea (Rhea americana) is a large cursorial palaeognathous bird with long legs and powerful musculature. Read More

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http://dx.doi.org/10.1111/joa.13158DOI Listing

Cardio-facio-cutaneous syndrome-associated pathogenic MAP2K1 variants activate autophagy.

Gene 2020 Apr 20;733:144369. Epub 2020 Jan 20.

Genetic and Metabolic Central Laboratory, Birth Defect Prevention Research Institute, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning, China; Division of Genetics and Genomics, Boston Children's Hospital, Department of Neurology, Harvard Medical School, Boston, MA, USA. Electronic address:

MAP2K1 encodes mitogen-activated protein kinase 1 (MEK1). Mutations in MAP2K1 lead to continuous activation of MEK/ERK signaling pathway, giving rise to cardio-facio-cutaneous syndrome (CFCS). However, the molecular mechanisms of abnormal activation of MEK/ERK signaling pathway and the role of autophagy, if any, in manifesting CFCS in MAP2K mutants remain unclear. Read More

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http://dx.doi.org/10.1016/j.gene.2020.144369DOI Listing

The autophagic-lysosomal and ubiquitin proteasome systems are simultaneously activated in the skeletal muscle of gastric cancer patients with cachexia.

Am J Clin Nutr 2020 03;111(3):570-579

Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu Province, China.

Background: Cancer cachexia is characterized by weight loss, especially ongoing skeletal muscle loss, and is associated with poor patient outcomes. However, the molecular mechanism of skeletal muscle wasting is not fully understood.

Objectives: We aimed to investigate muscle fiber morphology and proteolysis system activity changes that may account for cancer cachexia and to relate these changes to patients' clinical phenotypes. Read More

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http://dx.doi.org/10.1093/ajcn/nqz347DOI Listing

Genome-Wide Association Study of Body Weight Traits in Chinese Fine-Wool Sheep.

Animals (Basel) 2020 Jan 19;10(1). Epub 2020 Jan 19.

Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Lanzhou 730050, China.

Body weight is an important economic trait for sheep and it is vital for their successful production and breeding. Therefore, identifying the genomic regions and biological pathways that contribute to understanding variability in body weight traits is significant for selection purposes. In this study, the genome-wide associations of birth, weaning, yearling, and adult weights of 460 fine-wool sheep were determined using resequencing technology. Read More

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http://dx.doi.org/10.3390/ani10010170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7022301PMC
January 2020

Bed-Exit Prediction Applying Neural Network Combining Bed Position Detection and Patient Posture Estimation.

Conf Proc IEEE Eng Med Biol Soc 2019 07;2019:3208-3211

The work of a nurse involves tasks that can lead to serious accidents with a single mistake or miss, and thus nurses are exposed to high stress. In particular, injections, pre-medications, tube connections, and falling are factors that lead to serious accidents and are considered a major part of the load of nursing work. To reduce the burden of nursing work, we are working on developing a sensing system to prevent fall accidents. Read More

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http://dx.doi.org/10.1109/EMBC.2019.8857233DOI Listing

Estimation of Time-Varying Ankle Joint Stiffness Under Dynamic Conditions via System Identification Techniques.

Conf Proc IEEE Eng Med Biol Soc 2019 07;2019:2119-2122

An important goal in the design of next-generation exoskeletons and limb prostheses is to replicate human limb dynamics. Joint impedance determines the dynamic relation between joint displacement and torque. Joint stiffness is the position-dependent component of joint impedance and is key in postural control and movement. Read More

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http://dx.doi.org/10.1109/EMBC.2019.8856423DOI Listing

Muscle force characteristics of male and female collegiate cross-country runners during overground running.

J Sports Sci 2020 Mar 10;38(5):542-551. Epub 2020 Jan 10.

Department of Physical Therapy, College of Allied Health Science, East Carolina University, Greenville, NC, USA.

Males and females demonstrate unique running mechanics that may contribute to sex-related differences in common running related injuries. Understanding differences in muscle forces during running may inform intervention approaches, such as gait retraining addressing muscle force distribution. The purpose of this study was to compare muscle force characteristics and inter-trial variability between males and females during running. Read More

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http://dx.doi.org/10.1080/02640414.2020.1713689DOI Listing