6,457 results match your criteria Sjogren Syndrome


Review of the Major and Minor Salivary Glands, Part 1: Anatomy, Infectious, and Inflammatory Processes.

J Clin Imaging Sci 2018 15;8:47. Epub 2018 Nov 15.

Department of Imaging Sciences, University of Rochester Medical Center, Rochester, New York, USA.

The major and minor salivary glands of the head and neck are important structures that contribute to many of the normal physiologic processes of the aerodigestive tract. The major salivary glands are routinely included within the field of view of standard neuroimaging, and although easily identifiable, salivary pathology is relatively rare and often easy to overlook. Knowledge of the normal and abnormal imaging appearance of the salivary glands is critical for forming useful differential diagnoses, as well as initiating proper clinical workup for what are often incidental findings. Read More

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November 2018

Management of Primary Sjögren's Syndrome.

Consult Pharm 2018 Dec;33(12):691-701

: Review the clinical manifestations and treatment of primary Sjögren's syndrome. : Articles indexed in PubMed, Scopus, and the Cochrane Library in the past 10 years using the key words "Sjögren," "Sjögren's syndrome," "Sjögren's disease," and "Sjögren's syndrome AND treatment." Primary sources were used to locate additional resources. Read More

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December 2018
1 Read

Association between Helicobacter pylori infection and Sjögren syndrome: A meta-analysis.

Medicine (Baltimore) 2018 Dec;97(49):e13528

First Clinical Medical College of Nanjing Medical University.

Background: Helicobacter pylori has been proved as a risk factor of many diseases. There are some researches trying to find connection between H. pylori and Sjögren syndrome (SS). Read More

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December 2018

Prevalence and Demographic Characteristics of Sjögren's Syndrome in Colombia, Based on Information from the Official Ministry of Health Registry.

Reumatol Clin 2018 Dec 3. Epub 2018 Dec 3.

Departamento de Epidemiología Clínica y Bioestadística, Facultad de Medicina, Pontificia Universidad Javeriana, Bogotá, Colombia.

Objective: To calculate the prevalence and describe the main demographic characteristics of Sjögren's syndrome in adults in Colombia.

Material And Methods: Descriptive cross-sectional study which utilized data from the Integral Information System of Social Protection of the Ministry of Health of the Republic of Colombia during the years 2012 to 2016.

Results: 58,680 cases of Sjögren's syndrome were identified, with a prevalence in those over 18 years of age of 0. Read More

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December 2018

A Case of Sjögren's Syndrome Mimicking Inflammatory Myopathy.

Cureus 2018 Oct 1;10(10):e3393. Epub 2018 Oct 1.

Neurology, Keck School of Medicine of the University of Southern California, Los Angeles, USA.

Sjögren's syndrome (SS) is a chronic autoimmune disorder, characterized by lymphocytic infiltration of exocrine glands and causing the decreased function of lacrimal and salivary glands. We describe a case of a 34-year-old male who presented with Sjögren's syndrome presenting as myopathy and sensorimotor neuropathy. His creatinine kinase levels were elevated with positive anti-Sjögren's syndrome-related antigen A autoantibodies and anti-Sjögren's syndrome Type B autoantibodies. Read More

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October 2018

Neuroprotective modulation of the unfolded protein response in Marinesco-Sjögren syndrome: PERK signaling inhibition and beyond.

Neural Regen Res 2019 Jan;14(1):62-64

Department of Neuroscience, IRCCS - Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.

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January 2019

Galectin-9 reflects the interferon signature and correlates with disease activity in systemic autoimmune diseases.

Ann Rheum Dis 2018 Dec 8. Epub 2018 Dec 8.

Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.

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December 2018

An interdomain bridge influences RNA binding of the human La protein.

J Biol Chem 2018 Dec 10. Epub 2018 Dec 10.

Biology, York University, Canada.

La proteins are RNA chaperones that perform various functions depending on distinct RNA-binding modes and their subcellular localization. In the nucleus, they help process UUU-3'OH-tailed nascent RNA polymerase III transcripts, such as pre-tRNAs, whereas in the cytoplasm they contribute to translation of poly(A)-tailed mRNAs. La accumulation in the nucleus and cytoplasm is controlled by several trafficking elements, including a canonical nuclear localization signal (NLS) in the extreme C terminus and a nuclear retention element (NRE) in the RNA recognition motif 2 (RRM2) domain. Read More

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December 2018
1 Read

Effectiveness of technology-based distance physical rehabilitation interventions for improving physical functioning in stroke: a systematic review and meta-analysis of randomized controlled trials.

Arch Phys Med Rehabil 2018 Dec 6. Epub 2018 Dec 6.

Faculty of Sport and Health Science, University of Jyvaskyla, Jyväskylä, Finland.

Objective: To study the effectiveness of technology-based distance physical rehabilitation interventions on physical functioning in stroke.

Data Sources: A systematic literature search was conducted in six databases from January 2000 to May 2018.

Study Selection: Inclusion criteria applied PICOS (Patient, Intervention, Comparison, Outcome, Study design) framework as follows: (P) stroke; (I) technology-based distance physical rehabilitation interventions; (C) any comparison without the use of technology; (O) physical functioning; (S) randomized controlled trials (RCTs). Read More

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December 2018

Emergence and Spread of Basal Lineages of Yersinia pestis during the Neolithic Decline.

Cell 2018 Dec 5. Epub 2018 Dec 5.

Department of Bio and Health Informatics, Technical University of Denmark, Kemitorvet 208, 2800 Kongens Lyngby, Denmark. Electronic address:

Between 5,000 and 6,000 years ago, many Neolithic societies declined throughout western Eurasia due to a combination of factors that are still largely debated. Here, we report the discovery and genome reconstruction of Yersiniapestis, the etiological agent of plague, in Neolithic farmers in Sweden, pre-dating and basal to all modern and ancient known strains of this pathogen. We investigated the history of this strain by combining phylogenetic and molecular clock analyses of the bacterial genome, detailed archaeological information, and genomic analyses from infected individuals and hundreds of ancient human samples across Eurasia. Read More

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December 2018

Ly9 (CD229) Antibody Targeting Depletes Marginal Zone and Germinal Center B Cells in Lymphoid Tissues and Reduces Salivary Gland Inflammation in a Mouse Model of Sjögren's Syndrome.

Front Immunol 2018 16;9:2661. Epub 2018 Nov 16.

Immunology Unit, Department of Biomedical Sciences, Medical School, University of Barcelona, Barcelona, Spain.

Sjögren's Syndrome (SjS) is a common chronic autoimmune disease characterized by the B cell hyperactivation, lymphocyte infiltration, and tissue damage of exocrine glands. It can also present life-threatening extraglandular manifestations, such as pulmonary and hepatic involvement, renal inflammation and marginal zone (MZ) B cell lymphoma. Several biologic agents have been tested in SjS but none has shown significant efficacy. Read More

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November 2018
3 Reads

Siglec-1 Macrophages and the Contribution of IFN to the Development of Autoimmune Congenital Heart Block.

J Immunol 2018 Dec 5. Epub 2018 Dec 5.

Division of Rheumatology, Department of Medicine, New York University School of Medicine, New York, NY 10016.

Given that diseases associated with anti-SSA/Ro autoantibodies, such as systemic lupus erythematosus and Sjögren syndrome, are linked with an upregulation of IFN and type I IFN-stimulated genes, including sialic acid-binding Ig-like lectin 1 (Siglec-1), a receptor on monocytes/macrophages, recent attention has focused on a potential role for IFN and IFN-stimulated genes in the pathogenesis of congenital heart block (CHB). Accordingly, three approaches were leveraged to address the association of IFN, IFN-stimulated genes, and the phenotype of macrophages in affected fetal cardiac tissue: 1) cultured healthy human macrophages transfected with hY3, an anti-SSA/Ro-associated ssRNA, 2) RNA isolated from freshly sorted human leukocytes/macrophages after Langendorff perfusion of three fetal hearts dying with CHB and three healthy gestational age-matched hearts, and 3) autopsy tissue from three additional human CHB hearts and one healthy heart. TLR ligation of macrophages with hY3 led to the upregulation of a panel of IFN transcripts, including SIGLEC1, a result corroborated using quantitative PCR. Read More

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December 2018
1 Read

Reduced Corneal Innervation in the CD25 Null Model of Sjögren Syndrome.

Int J Mol Sci 2018 Nov 30;19(12). Epub 2018 Nov 30.

Department of Ophthalmology, Ocular Surface Center, Cullen Eye Institute, Baylor College of Medicine, Houston, TX 77030, USA.

Decreased corneal innervation is frequent in patients with Sjögren Syndrome (SS). To investigate the density and morphology of the intraepithelial corneal nerves (ICNs), corneal sensitivity, epithelial cell proliferation, and changes in mRNA expression of genes that are involved in autophagy and axon targeting and extension were assessed using the IL-2 receptor alpha chain (CD25 null) model of SS. ICN density and thickness in male and female wt and CD25 null corneas were assessed at 4, 6, 8, and 10/11 wk of age. Read More

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November 2018
1 Read

Functional Head Impulse Testing Might Be Useful for Assessing Vestibular Compensation After Unilateral Vestibular Loss.

Front Neurol 2018 19;9:979. Epub 2018 Nov 19.

Department of Clinical Sciences Lund, Faculty of Medicine, Skåne University Hospital, Lund University, Lund, Sweden.

Loss of the vestibulo-ocular reflex (VOR) affects visual acuity during head movements. Previous studies have shown that compensatory eye-saccades improve visual acuity and that the timing of the saccade is important. Most of the tests involved in testing VOR are made with passive head movement, that do not necessarily reflect the activities of daily living and thus not being proportionate to symptoms and distresses of the patients. Read More

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November 2018
5 Reads

Difference in Outcome Following Surgery for Native Aortic and Mitral Valve Infective Endocarditis.

Thorac Cardiovasc Surg 2018 Nov 30. Epub 2018 Nov 30.

Department of Cardiothoracic Surgery, Skane University Hospital and Lund University, Lund, Sweden.

Background:  We investigated differences in clinical presentation, microbiology, and short- and long-term results according to the affected valve in patients who underwent surgery for left-sided native valve infective endocarditis (IE).

Methods:  This was a single-center retrospective study of 117 patients with isolated mitral valve IE (group M) and 140 patients with isolated aortic valve IE (group A) who underwent surgery between 1998 and 2015.

Results:  The mean age of patients in group M was 62 ± 14 years, whereas in group A the patients were 56 ± 14 years old ( = 0. Read More

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November 2018
9 Reads

Normal vaginal microbiome in women with primary Sjögren's syndrome-associated vaginal dryness.

Ann Rheum Dis 2018 Nov 28. Epub 2018 Nov 28.

Department of Rheumatology & Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

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November 2018

DRESS/DIHS caused by levofloxacin in a patient with systemic scleroderma, rheumatoid arthritis, and Sjogren syndrome.

Contact Dermatitis 2018 Nov 28. Epub 2018 Nov 28.

Department of Endocrinology, Metabolism and Nephrology, Kochi Medical School, Nankoku, Kochi, Japan.

Drug-induced hypersensitivity syndrome (DIHS) or drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare, severe skin disease with manifestations such as fever, eosinophilia, lymphadenopathy and internal organ damage that typically develops 2 to 6 weeks after drug intake. DRESS/DIHS follows a prolonged course involving frequent flare-ups and relapses over weeks or months after treatment discontinuation. Read More

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November 2018
2 Reads

CD99 expression is strongly associated with clinical outcome in children with B-cell precursor acute lymphoblastic leukaemia.

Br J Haematol 2018 Nov 28. Epub 2018 Nov 28.

Department of Rheumatology and Inflammation Research, University of Gothenburg, Gothenburg, Sweden.

Our study aimed to determine the expression pattern and clinical relevance of CD99 in paediatric B-cell precursor acute lymphoblastic leukaemia (BCP-ALL). Our findings demonstrate that high expression levels of CD99 are mainly found in high-risk BCP-ALL, e.g. Read More

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November 2018
1 Read

Sex Effects on Gene Expression in Lacrimal Glands of Mouse Models of Sjögren Syndrome.

Invest Ophthalmol Vis Sci 2018 Nov;59(13):5599-5614

Schepens Eye Research Institute of Massachusetts Eye and Ear, Boston, Massachusetts, United States.

Purpose: Sjögren syndrome is an autoimmune disease that occurs primarily in women, and is associated with lacrimal gland inflammation and aqueous-deficient dry eye. We hypothesize that sex-associated differences in lacrimal gland gene expression are very important in promoting lymphocyte accumulation in this tissue and contribute to the onset, progression, and/or severity of the inflammatory disease process. To test our hypothesis, we explored the nature and extent of sex-related differences in gene expression in autoimmune lacrimal glands. Read More

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November 2018
4 Reads

Facial Plaque in a Woman With Sjogren Syndrome: Answer.

Am J Dermatopathol 2018 Dec;40(12):933-934

Departments of Dermatology and.

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December 2018
1 Read

Phosphatidylinositol 3-kinase delta pathway: a novel therapeutic target for Sjögren's syndrome.

Ann Rheum Dis 2018 Nov 24. Epub 2018 Nov 24.

Centre for Translational Inflammation Research, Institute of Inflammation and Ageing, College of Medical & Dental Sciences, University of Birmingham, Research Laboratories, Queen Elizabeth Hospital, Birmingham, UK

Background: The phosphatidylinositol 3-kinase delta isoform (PI3Kδ) belongs to an intracellular lipid kinase family that regulate lymphocyte metabolism, survival, proliferation, apoptosis and migration and has been successfully targeted in B-cell malignancies. Primary Sjögren's syndrome (pSS) is a chronic immune-mediated inflammatory disease characterised by exocrine gland lymphocytic infiltration and B-cell hyperactivation which results in systemic manifestations, autoantibody production and loss of glandular function. Given the central role of B cells in pSS pathogenesis, we investigated PI3Kδ pathway activation in pSS and the functional consequences of blocking PI3Kδ in a murine model of focal sialoadenitis that mimics some features of pSS. Read More

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November 2018
1 Read

Connective Tissue Disorders in Pregnancy.

Neurol Clin 2019 Feb;37(1):121-129

Department of Neurology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA; Department of Neurology, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.

Connective tissue disorders are now understood to include autoimmune and genetic diseases affecting organs, blood vessels, and surrounding fascia. Many of these diseases predominantly affect women in childbearing years and are associated with neurologic complications. Pregnancy can affect disease activity (such as flares of systemic lupus erythematosus), and the diseases can affect pregnancy outcome (such as increased risk of preterm labor). Read More

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February 2019
6 Reads

SIL1 deficiency causes degenerative changes of peripheral nerves and neuromuscular junctions in fish, mice and human.

Neurobiol Dis 2018 Nov 20;124:218-229. Epub 2018 Nov 20.

Leibniz-Institut für Analytische Wissenschaften, ISAS, e.V. Dortmund, 44227, Dortmund, Germany; Institute of Neuropathology, University Hospital RWTH Aachen, Aachen, 52074, Germany; Pediatric Neurology, University Childrens Hospital, University of Duisburg-Essen, Faculty of Medicine, Essen, Germany. Electronic address:

Background: Marinesco-Sjögren Syndrome (MSS) is a rare neuromuscular condition caused by recessive mutations in the SIL1 gene resulting in the absence of functional SIL1 protein, a co-chaperone for the major ER chaperone, BiP. As BiP is decisive for proper protein processing, loss of SIL1 results in the accumulation of misshaped proteins. This accumulation likely damages and destroys cells in vulnerable tissues, leading to congenital cataracts, cerebellar ataxia, vacuolar myopathy and other MSS phenotypes. Read More

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November 2018
5 Reads

CCL22-Producing Resident Macrophages Enhance T Cell Response in Sjögren's Syndrome.

Front Immunol 2018 8;9:2594. Epub 2018 Nov 8.

Department of Oral Molecular Pathology, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.

Macrophages (MΦs) are critical regulators of immune response and serve as a link between innate and acquired immunity. The precise mechanism of involvement of tissue-resident MΦs in the pathogenesis of autoimmune diseases is not clear. Here, using a murine model for Sjögren's syndrome (SS), we investigated the role of tissue-resident MΦs in the onset and development of autoimmunity. Read More

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November 2018
5 Reads

Recurrent Cerebral Infarctions in Primary Sjögren Syndrome: A Case Report and Literature Review.

Front Neurol 2018 16;9:865. Epub 2018 Oct 16.

Department of Neurology, The First Hospital of Jilin University, Changchun, China.

Recurrent cerebral infarctions are extremely rare in patients with primary Sjögren syndrome. We report a 66-year-old woman who was admitted to our hospital due to acute cerebral infarction with exacerbation of dysphagia and right-sided hemiplegia as the main symptoms. In the past 3 months, she had developed cerebral infarction twice, even though she had no risk factors for atherosclerosis. Read More

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October 2018
3 Reads

Antinuclear autoantibodies: discordance among four different assays.

Ann Rheum Dis 2018 Nov 20. Epub 2018 Nov 20.

Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad Del Rosario, Bogotá, Colombia

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November 2018
2 Reads

Cluster analysis of autoimmune rheumatic diseases based on autoantibodies. New insights for polyautoimmunity.

J Autoimmun 2018 Nov 17. Epub 2018 Nov 17.

Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Bogota, Colombia. Electronic address:

Autoimmune diseases (ADs) are a chronic and clinically heterogeneous group of diseases characterized by share common immunopathogenic mechanisms and risk factors (i.e., the autoimmune tautology), which explain the fact that one AD may coexist with others (i. Read More

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November 2018
3 Reads

[Sjögren-Larsson syndrome: Pediatric case report].

Arch Argent Pediatr 2018 Dec;116(6):e773-e777

Laboratorio de Bioquímica y Medicina Experimental, Centro Médico Nacional "20 de Noviembre", ISSSTE.

Sjogren-Larsson syndrome is characterized by congenital ichthyosis, mental retardation and spastic diplegia or quadriplegia. The primary defect in this syndrome is mutation of ALDH3A2 gen that codes for the fatty aldehyde dehydrogenase. Deficiency of this enzyme causes an accumulation of fatty alcohols and fatty aldehydes, leading to altered cell-membrane integrity. Read More

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December 2018
1 Read

Gene Expression Profiling of Lacrimal Glands Identifies the Ectopic Expression of MHC II on Glandular Cells as a Presymptomatic Feature in a Mouse Model of Primary Sjögren's Syndrome.

Front Immunol 2018 31;9:2362. Epub 2018 Oct 31.

Xiamen-Borstel Joint Laboratory of Autoimmunity, The Medical College of Xiamen University, Xiamen, China.

Ectopic expression of MHC II molecules on glandular cells is a feature of primary Sjögren's syndrome (pSS). However, the cause of this ectopic expression and its potential role in the pathogenesis of the disease remains elusive. Here, we report that ectopic expression of MHC II molecules on glandular cells represents an early presymptomatic event in a mouse model of pSS induced by immunization of Ro60_316-335 peptide emulsified in TiterMax® as an adjuvant. Read More

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October 2018
7 Reads

Initial presentation determines clinical entity in patients with anti-centromere antibody positivity.

Int J Rheum Dis 2018 Nov 14. Epub 2018 Nov 14.

Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.

Aim: Anti-centromere antibody (ACA) is often detected in patients with autoimmune diseases, including limited cutaneous systemic sclerosis (SSc), Sjögren's syndrome (SS), and primary biliary cholangitis (PBC). The association between autoimmune disease and ACA positivity remains unclear. We sought to clarify the clinical features of ACA-positive patients and their association with autoantibodies. Read More

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November 2018
3 Reads

Effect of home-based specialised palliative care and dyadic psychological intervention on caregiver anxiety and depression: a randomised controlled trial.

Br J Cancer 2018 Nov 14;119(11):1307-1315. Epub 2018 Nov 14.

Danish Cancer Society Research Center, Copenhagen, Denmark.

Background: Specialised palliative care trials often fail to address intervention effects on caregiver anxiety and depression, particularly in bereavement. We evaluate effects of specialised palliative care and dyadic psychological intervention on caregiver anxiety and depression in a randomised controlled trial (RCT).

Methods: Patients with incurable cancer and limited antineoplastic treatment options and their caregivers, recruited from a university hospital oncology department, were randomised (1:1) to care as usual or accelerated transition from oncological treatment to home-based specialised palliative care. Read More

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November 2018
1 Read

Overactive bladder symptom bother and health-related quality of life in patients with systemic lupus erythematosus and primary Sjögren syndrome.

Lupus 2018 Nov 12:961203318811605. Epub 2018 Nov 12.

1 Urology Department, Hospital de Santa Maria, Centro Hospitalar Lisboa Norte, Centro Académico de Medicina de Lisboa, Lisbon, Portugal.

Objective: The objective of this paper is to assess overactive bladder (OAB) symptom bother (SB) and health-related quality of life (HRQL) among patients with systemic lupus erythematosus (SLE) and primary Sjögren syndrome (pSS).

Methods: We recruited adult SLE and pSS patients and two groups of age- and sex-matched controls. We applied the OAB questionnaire-short form (OABq-SF) to all participants to assess SB and HRQL and collected clinical information relevant for OAB. Read More

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November 2018
1 Read

Single bead investigation of a clinical drug delivery system - A novel release mechanism.

J Control Release 2018 Dec 10;292:235-247. Epub 2018 Nov 10.

Department of Pharmacy, Uppsala University, Box 580, 751 23 Uppsala, Sweden. Electronic address:

Microgels, such as polymeric hydrogels, are currently used as drug delivery devices (DDSs) for chemotherapeutics and/or unstable drugs. The clinical DDS DC bead® was studied with respect to loading and release, measured as relative bead-volume, of six amphiphilic molecules in a micropipette-assisted microscopy method. Theoretical models for loading and release was used to increase the mechanistic understanding of the DDS. Read More

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December 2018
14 Reads

Systematic fast-track transition from oncological treatment to dyadic specialized palliative home care: DOMUS - a randomized clinical trial.

Palliat Med 2018 Nov 12:269216318811269. Epub 2018 Nov 12.

1 Department of Oncology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.

Background:: The focus of specialized palliative care is to improve quality of life for patients with incurable cancer and their relatives including an increased opportunity to make their own choice of place of care and death.

Aim:: To investigate whether a systematic fast-track transition from oncological treatment to specialized palliative care at home for patients with incurable cancer reinforced with a psychological dyadic intervention could result in more time spent at home and death at home. Secondary aims were to investigate effects on quality of life, symptomatology and survival. Read More

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November 2018
1 Read

Physical activity on prescription in accordance with the Swedish model increases physical activity: a systematic review.

Br J Sports Med 2018 Nov 9. Epub 2018 Nov 9.

Department of Food and Nutrition and Sport Science, Centre for Health and Performance, University of Gothenburg, Gothenburg, Sweden.

Objectives: This study investigates the effects of the core elements of the Swedish model for physical activity on prescription (PAP) by evaluating studies that compared adults who received PAP with adults who did not receive PAP. All participants were adults identified by a healthcare professional as in need of increased physical activity. Primary outcome was level of physical activity. Read More

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November 2018
6 Reads

Relapsed/refractory acquired thrombotic thrombocytopenic purpura in a patient with Sjögren syndrome: Case report and review of the literature.

Medicine (Baltimore) 2018 Oct;97(43):e12989

Department of Immunology and Rheumatology.

Rationale: Thrombotic thrombocytopenic purpura (TTP) is a rare, fatal disorder which could be caused by autoimmune diseases. However, TTP secondary to Sjögren syndrome (SS) is extremely rare.

Patient Concerns: A 47-year- old woman with an 8-year history of SS was admitted due to skin ecchymosis and bleeding gums. Read More

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October 2018
10 Reads

Arthritis in primary Sjögren's syndrome: Characteristics, outcome and treatment from French multicenter retrospective study.

Autoimmun Rev 2018 Nov 5. Epub 2018 Nov 5.

Service de médecine interne, Hôpital Saint-Antoine, APHP, Paris, France; Sorbonne Université, INSERM, Centre de Recherche Saint-Antoine (CRSA), F-75012 Paris, France. Electronic address:

Objective: To describe the characteristics and the outcome of primary Sjögren Syndrome (pSS) associated arthritis and to compare the efficacy of different therapeutic regimen.

Methods: We conducted a retrospective study using Club Rhumatisme and Inflammation (CRI) and French Internal Medicine Society (SNFMI) networks. All patients with a diagnosis of pSS and at least one episode of clinical and/or echographic synovitis were included. Read More

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November 2018
9 Reads

Guidelines for biomarkers in autoimmune rheumatic diseases - evidence based analysis.

Autoimmun Rev 2018 Nov 5. Epub 2018 Nov 5.

Pathophysiology Department, General Hospital of Athens "Laiko", Medical School, National and Kapodistrian University of Athens, Greece.

Autoimmune rheumatic diseases are characterised by an abnormal immune system response, complement activation, cytokines dysregulation and inflammation. In last years, despite many progresses in managing these patients, it has been shown that clinical remission is reached in less than 50% of patients and a personalised and tailored therapeutic approach is still lacking resulting in a significant gap between guidelines and real-world practice. In this context, the need for biomarkers facilitating early diagnosis and profiling those individuals at the highest risk for a poor outcome has become of crucial interest. Read More

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November 2018
7 Reads

Cohabitation Status Influenced Admittance to Specialized Palliative Care for Cancer Patients: A Nationwide Study from the Danish Palliative Care Database.

J Palliat Med 2018 Nov 7. Epub 2018 Nov 7.

1 Research Unit, Department of Palliative Medicine, Bispebjerg Hospital, University of Copenhagen , Copenhagen, Denmark .

Background: The utilization of the health care system varies in relation to cohabitation status, but conflicting results have been found in studies investigating the association in relation to specialized palliative care (SPC).

Objective: To investigate the association between cohabitation status and admittance to SPC; to establish whether this association differed between hospital-based palliative care team/units (mainly outpatient/home care) and hospice (mainly inpatient care).

Design: A nationwide study based on the Danish Palliative Care Database, which is linked with additional registers. Read More

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November 2018
5 Reads

[A new mutation in the ALDH3A2 gene in a boy with Sjogren-Larsson syndrome].

Rev Neurol 2018 Nov;67(10):415-416

Hospital Universitario Puerta del Mar, 11009 Cadiz, Espana.

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November 2018
1 Read

Association between systemic activity ındex and dry eye severity in patients with primary Sjögren syndrome.

Arq Bras Oftalmol 2018 Nov 1. Epub 2018 Nov 1.

Department of Rheumatology, Ankara Numune Education and Research Hospital, Turkey.

Purpose: The aim of the present study was to compare the severity of ocular and systemic findings among patients with primary Sjögren syndrome.

Methods: The study followed a prospective controlled design and comprised two groups; the test group included 58 eyes of 58 patients newly diagnosed with primary Sjögren syndrome with poor dry eye test findings and the control group included 45 right eyes of 45 healthy age- and sex-matched individuals. The ocular surface disease index score, tear osmolarity, Schirmer I test without anesthesia, fluorescein tear breakup time, and cornea-conjunctiva staining with lissamine green (van Bijsterveld scoring) were used to examine tear function in the patients via a complete ophthalmological examination. Read More

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November 2018
5 Reads

Sjögren's syndrome: state of the art on clinical practice guidelines.

RMD Open 2018 18;4(Suppl 1):e000789. Epub 2018 Oct 18.

Université Paris-Sud: AP-HP, Hôpitaux Universitaires Paris-Sud; INSERM UMR 1184, Le Kremlin Bicêtre, France.

Sjögren's syndrome (SS) is a complex autoimmune rheumatic disease that specifically targets salivary and lachrymal glands. As such, patients typically had ocular and oral dryness and salivary gland swelling. Moreover, skin, nasal and vaginal dryness are frequently present. Read More

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October 2018
11 Reads

Antiphospholipid syndrome: state of the art on clinical practice guidelines.

RMD Open 2018 18;4(Suppl 1):e000785. Epub 2018 Oct 18.

Rheumatology and Clinical Immunology Unit, Civil Hospital, Brescia, Italy.

Antiphospholipid syndrome (APS) is a rare disease characterised by venous and/or arterial thrombosis, pregnancy complications and the presence of specific autoantibodies called antiphospholipid antibodies. This review aims to identify existing clinical practice guidelines (CPG) as part of the ERN ReCONNET project, aimed at evaluating existing CPGs or recommendations in rare and complex diseases. Seventeen papers providing important data were identified; however, the literature search highlighted the scarceness of reliable clinical data to develop CPGs. Read More

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October 2018
15 Reads

Mixed connective tissue disease: state of the art on clinical practice guidelines.

RMD Open 2018 18;4(Suppl 1):e000783. Epub 2018 Oct 18.

Department of Rheumatology, Universitätsklinikum Düsseldorf, Düsseldorf, Germany.

Mixed connective tissue disease (MCTD) is a complex overlap disease with features of different autoimmune connective tissue diseases (CTDs) namely systemic sclerosis, poly/dermatomyositis and systemic lupus erythematous in patients with antibodies targeting the U1 small nuclear ribonucleoprotein particle. In this narrative review, we summarise the results of a systematic literature research which was performed as part of the European Reference Network on Rare and Complex Connective Tissue and Musculoskeletal Diseases project, aimed at evaluating existing clinical practice guidelines (CPGs) or recommendations. Since no specific CPGs on MCTD were found, other CPGs developed for other CTDs were taken into consideration in order to discuss what can be applied to MCTD even if designed for other diseases. Read More

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October 2018
10 Reads

Systemic sclerosis: state of the art on clinical practice guidelines.

RMD Open 2018 18;4(Suppl 1):e000782. Epub 2018 Oct 18.

Department of Clinical and Experimental Medicine, University of Florence, Florence, Italy.

Systemic sclerosis (SSc) is an orphan disease characterised by autoimmunity, fibrosis of the skin and internal organs, and vasculopathy. SSc may be associated with high morbidity and mortality. In this narrative review we summarise the results of a systematic literature research, which was performed as part of the European Reference Network on Rare and Complex Connective Tissue and Musculoskeletal Diseases project, aimed at evaluating existing clinical practice guidelines or recommendations. Read More

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October 2018
11 Reads

Comparative Assessment of Hand Joint Ultrasound Findings in Symptomatic Patients with Systemic Lupus Erythematosus and Sjögren's Syndrome: A Pilot Study.

Ultrasound Med Biol 2018 Nov 3. Epub 2018 Nov 3.

Department of Rheumatology, University College London Hospitals NHS Foundation Trust, London, United Kingdom; Division of Medicine, University College London, London, United Kingdom. Electronic address:

Systemic lupus erythematosus (SLE) and primary Sjögren's syndrome (SS) can be associated with inflammatory arthritis, which is underdiagnosed by clinical examination. The aim of this cross-sectional, observational study was to compare, for the first time, the ultrasound (US)-detected joint abnormalities in these two diseases and to define the role of US in patient management. Participants had SLE (n = 18) and SS (n = 23), symptoms of hand joint pain and no previous diagnosis of arthritis. Read More

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November 2018
3 Reads

Epidermal Fatty Acid-Binding Protein: A Novel Marker in the Diagnosis of Dry Eye Disease in Sjögren Syndrome.

Int J Mol Sci 2018 Nov 4;19(11). Epub 2018 Nov 4.

Department of Ophthalmology, Tokyo Dental College, Ichikawa General Hospital, Chiba 2728513, Japan.

Purpose: Sjögren syndrome (SS) is a chronic inflammatory autoimmune disease of the lacrimal and salivary glands. This study compared the concentrations of epidermal fatty-acid binding protein (E-FABP) in the saliva, serum, and tears of SS patients with dry eye and dry mouth, with those of healthy adults to investigate the usefulness of E-FABP as a diagnostic marker for SS.

Design: Prospective, observational case series. Read More

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November 2018
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Significance of M2 macrophage in tubulointerstitial disease secondary to primary Sjogren's disease.

Ren Fail 2018 Nov;40(1):634-639

c Department of Nephrology , Clinical Medical College, Yangzhou University , Yangzhou , China.

Objective: M2 Macrophages could improve tubulointerstitial disease in animal models. HIF-1αpromotes macrophage polarization and is involved in tubular injury. The study aims to observe the clinicopathologic significance of M2 macrophage and HIF-1α in tubulointerstitial injury secondary to primary Sjogren's disease. Read More

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November 2018
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0.775 Impact Factor

[Clinical features of patients with primary Sjögren's syndrome complicated with venous thrombosis].

Authors:
Y F Zhang Y W Lu

Zhonghua Yi Xue Za Zhi 2018 Oct;98(39):3197-3199

To analyze the clinical characteristics of primary Sjögren's syndrome (pSS) with venous system thrombosis (VT), and to improve the understanding of the disease. The clinical and laboratory characteristics of 16 cases of pSS with VT were analyzed retrospectively. Among 16 cases, 12 cases was women, 2 case was men, age between 45 and 71. Read More

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October 2018
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