16,993 results match your criteria Sjogren Syndrome


Cerebral cortex impairment in neuromyelitis optica spectrum disorder: A case report and literature review.

Mult Scler Relat Disord 2019 Apr 6;32:9-12. Epub 2019 Apr 6.

Department of Neurology, Chinese PLA General Hospital, Beijing, China. Electronic address:

Background: Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune disorder of the central nervous system that usually presents with acute myelitis and/or optic neuritis. Cortical lesions used to be regarded as "red flags" of NMOSD, and indicated the possibility of alternative diagnoses. We recently had reported a NMOSD patient with weakness in both lower limbs resulting from cortical damage, which was usually attributed to spinal cord lesions. Read More

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http://dx.doi.org/10.1016/j.msard.2019.04.005DOI Listing

Lysosomal pH Is Regulated in a Sex Dependent Manner in Immune Cells Expressing .

Front Immunol 2019 2;10:578. Epub 2019 Apr 2.

Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, United States.

and both contain risk alleles for systemic lupus erythematosus (SLE) and Sjögren's syndrome (pSS). The former escapes X inactivation. Our group predicts specific endolysosomal-dependent immune responses are driven by the protein products of these genes, which form a complex at the endolysosomal surface. Read More

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https://www.frontiersin.org/article/10.3389/fimmu.2019.00578
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http://dx.doi.org/10.3389/fimmu.2019.00578DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454867PMC
April 2019
1 Read

Neuromyelitis optic with positive Anti-AQP4 and Anti-SSA/Ro antibody.

Neurol Int 2019 Mar 11;11(1):7958. Epub 2019 Mar 11.

Department of Neurology.

Neuromyelitis Optic (NMO) is an inflammatory disorder involving central nervous system which often co-exists with other autoimmune diseases such as Sjögren's syndrome (SS). NMO manifestation could precede or follow SS, but the role of anti-SSA in the pathogenesis of NMO remains unclear. We present a case of NMO with anti-AQP4 anti-SSA antibody positive. Read More

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https://www.pagepress.org/journals/index.php/ni/article/view
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http://dx.doi.org/10.4081/ni.2019.7958DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444563PMC
March 2019
1 Read

Coexistence of Mixed Connective Tissue Disease and Familial Mediterranean Fever in a Japanese Patient: A Case Report.

Intern Med 2019 Apr 17. Epub 2019 Apr 17.

Department of Rheumatology, Fukushima Medical University School of Medicine, Japan.

We herein report a Japanese patient with familial Mediterranean fever (FMF) who developed the clinical manifestations of mixed connective tissue disease (MCTD) and Sjögren's syndrome. The patient was a 36-year-old woman presenting with a periodic short-duration (2-3 days) fever and pleural pain. An MEFV gene analysis detected a complex allele mutation (P369S/R408Q) in exon 3 of the MEFV gene. Read More

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http://dx.doi.org/10.2169/internalmedicine.2376-18DOI Listing

Sicca Syndrome Associated with Immune Checkpoint Inhibitor Therapy.

Oncologist 2019 Apr 17. Epub 2019 Apr 17.

Sjögren's Syndrome and Salivary Gland Dysfunction Unit, National Institutes of Health, Baltimore, Maryland, USA.

Background: The objective of this study was to characterize the clinicopathologic features of sicca syndrome associated with immune checkpoint inhibitor (ICI) therapy.

Subjects, Materials, And Methods: Consecutive patients with new or worsening xerostomia in the setting of ICI treatment for benign or malignant neoplastic disease were evaluated, including labial salivary gland biopsy (LSGB).

Results: Twenty patients (14 male; median age 57 years) had metastatic melanoma ( = 10), metastatic carcinoma ( = 6), or recurrent respiratory papillomatosis ( = 4) and were being treated with avelumab ( = 8), nivolumab ( = 5), pembrolizumab ( = 4), nivolumab/ipilimumab ( = 2), and M7824, a biologic targeting programmed cell death ligand 1 (PD-L1) and transforming growth factor ß ( = 1). Read More

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http://theoncologist.alphamedpress.org/lookup/doi/10.1634/th
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http://dx.doi.org/10.1634/theoncologist.2018-0823DOI Listing
April 2019
3 Reads

Cognitive Function in Primary Sjögren's Syndrome: A Systematic Review.

Brain Sci 2019 Apr 15;9(4). Epub 2019 Apr 15.

Department of Old Age Psychiatry, Central and North West London NHS Foundation Trust, London UB8 3NN, UK.

Background: Cognitive disorders are reported to be common in patients with primary Sjogren's syndrome (pSS). In some cases, they are the first clinical manifestation, preceding the diagnosis of pSS by two years on average.

Aim: A systematic review was conducted to explore cognitive impairment in pSS, with reference to diagnostic methods and their relationship with laboratory data and clinical manifestations. Read More

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http://dx.doi.org/10.3390/brainsci9040085DOI Listing
April 2019
1 Read

Analysis of oral bacterial communities: comparison of HOMI with a tree-based approach implemented in QIIME.

J Oral Microbiol 2019 1;11(1):1586413. Epub 2019 Apr 1.

Sjögren's Syndrome Clinic, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.

Molecular taxonomic assignments in oral microbial communities have been made using probe-matching approaches, but never compared to those obtained by more readily accepted tree-based approaches.  To compare community composition profiles obtained from a probe-matching approach (HOMI) to those from a closed-ended tree-based approach (QIIME using the eHOMD database).  HOMIand QIIME were used for parallel analysis of ten mock community samples, and of 119 supragingival plaque samples from ecologically unique sites (sound tooth surfaces in healthy subjects, sound tooth surfaces in patients with primary Sjögren's Syndrome, and carious lesions in Sjögren's Syndrome patients). Read More

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https://www.tandfonline.com/doi/full/10.1080/20002297.2019.1
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http://dx.doi.org/10.1080/20002297.2019.1586413DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450576PMC
April 2019
2 Reads

Evaluation of the Efficacy and Safety of A Novel 0.05% Cyclosporin A Topical Nanoemulsion in Primary Sjögren's Syndrome Dry Eye.

Ocul Immunol Inflamm 2019 Apr 15:1-9. Epub 2019 Apr 15.

a Department of Ophthalmology and Visual Science, Seoul St. Mary's Hospital , College of Medicine, The Catholic University of Korea , Seoul , Republic of Korea.

Purpose: To evaluate the efficacy and safety of a novel topical cyclosporin A 0.05% nanoemulsion in comparison with a conventional emulsion in primary Sjögren's syndrome dry eyes.

Methods: Prospective, randomized, double-blinded study was conducted. Read More

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http://dx.doi.org/10.1080/09273948.2019.1587470DOI Listing
April 2019
1 Read

Anti-FIRΔexon2, a splicing variant form of PUF60, auto-antibody is detected in the sera of esophageal squamous cell carcinoma.

Cancer Sci 2019 Apr 13. Epub 2019 Apr 13.

Department of Frontier Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.

Anti-PUF60 autoantibodies are reportedly detected in the sera of patients with dermatomyositis and Sjogren's syndrome; however, little is known regarding its existence in the sera of cancer patients. FIR, a splicing variant of the PUF60 gene, is a transcriptional repressor of c-myc. In colorectal cancer, there is an overexpression of the dominant negative form of FIR, in which exon 2 is lacking (FIRΔexon2). Read More

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http://dx.doi.org/10.1111/cas.14024DOI Listing
April 2019
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Breast MALT lymphoma and AL amyloidosis complicating Sjögren's syndrome.

BMJ Case Rep 2019 Apr 11;12(4). Epub 2019 Apr 11.

Internal Medicine, Hopital Jean Verdier, Bondy, France.

Marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) lymphomas of the breast with mammary amyloidosis are exceedingly rare entities. This report describes the case of women with long-standing Sjögren's syndrome presenting with breast MALT lymphoma and amyloïd light-chain (AL) amyloidosis. Breast microcalcification needle biopsy made the positive diagnosis. Read More

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http://dx.doi.org/10.1136/bcr-2018-227581DOI Listing
April 2019
1 Read

Silicosis And Sjögren's Syndrome.

Arch Bronconeumol 2019 Apr 8. Epub 2019 Apr 8.

Servicio de Medicina Interna, Hospital Clínico Universitario de Valladolid, Valladolid, España.

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http://dx.doi.org/10.1016/j.arbres.2019.02.026DOI Listing
April 2019
1 Read

Sleep outcomes associated with dry eye disease: a systematic review and meta-analysis.

Can J Ophthalmol 2019 Apr 7;54(2):180-189. Epub 2018 Jun 7.

Department of Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, Western University, London, Ont; Department of Ophthalmology, Schulich School of Medicine and Dentistry, Western University, London, Ont.. Electronic address:

Objective: To summarize and quantitatively evaluate sleep outcomes of dry eye disease (DED) patients.

Design: A systematic review and meta-analysis.

Participants: DED patients were individuals with dry eye symptoms or primary Sjogren's syndrome (pSS). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00084182173124
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http://dx.doi.org/10.1016/j.jcjo.2018.03.013DOI Listing
April 2019
16 Reads

Septic shock among patients with systemic lupus erythematosus: Short and long-term outcome. Analysis of a French nationwide database.

J Infect 2019 Apr 8. Epub 2019 Apr 8.

APHP Medical and infectious diseases ICU Bichat hospital, F75018 Paris, France; IAME UMR 1137, Université Paris-Diderot Equipe 5 DeScID, France.

Objectives: We aimed to assess the characteristics, outcomes and costs of septic shock complicating Systemic Lupus Erythematosus (SLE).

Methods: Characteristics of SLE patients experiencing a septic shock in France from 2010 to 2015 were analyzed through the French medico-administrative database. Factors associated with the 1-year post-admission mortality were analyzed, the crude 1-year survival of SLE patients experiencing septic shock was compared to those admitted for another reason, and we compared the 1-year outcome associated with SLE septic shock survival to a matched SLE ICU control population. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01634453193011
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http://dx.doi.org/10.1016/j.jinf.2019.04.005DOI Listing
April 2019
5 Reads

Evaluation of corneal layers and anterior sclera in patients with primary Sjögren's syndrome.

Arq Bras Oftalmol 2019 Apr 8. Epub 2019 Apr 8.

Rheumatology Division, Pamukkale University, Denizli, Turkey.

Purpose: We aimed to compare the thickness of anterior sclera, corneal layers, and pre-ocular tear film between patients with primary Sjögren's syndrome and healthy individuals.

Methods: Fifty-one patients with primary Sjögren's syndrome and 41 healthy control participants were recruited in this cross-sectional and comparative study. The thickness of the pre-ocular tear film, corneal epithelium, Bowman's layer, stroma, Descemet's membrane, and endothelium were measured on the corneal apex. Read More

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http://dx.doi.org/10.5935/0004-2749.20190054DOI Listing
April 2019
3 Reads

Overlap myositis, a distinct entity beyond primary inflammatory myositis: A retrospective analysis of a large cohort from the REMICAM registry.

Int J Rheum Dis 2019 Apr 10. Epub 2019 Apr 10.

Servicio de Reumatología, Hospital General Universitario Gregorio Marañón, Madrid, Spain.

Background: Inflammatory idiopathic myositis (IIM) comprises a heterogeneous group of systemic muscular diseases that can occur together with other connective tissue diseases (CTD), named overlap myositis (OM). The question of whether OM is a distinct entity still remains controversial.

Aim: The present study was conducted to assess the clinical and prognostic differences between patients diagnosed with OM, primary polymyositis (PM) and primary dermatomyositis (DM). Read More

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http://dx.doi.org/10.1111/1756-185X.13559DOI Listing
April 2019
1 Read

Ablation of the Chaperone Protein ERdj5 Results in a Sjögren's Syndrome-Like Phenotype in Mice, Consistent With an Upregulated Unfolded Protein Response in Human Patients.

Front Immunol 2019 22;10:506. Epub 2019 Mar 22.

Division of Microbiology and Molecular Medicine, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.

Sjögren's syndrome (SS) is a chronic autoimmune disorder that affects mainly the exocrine glands. Endoplasmic reticulum (ER) stress proteins have been suggested to participate in autoimmune and inflammatory responses, either acting as autoantigens, or by modulating factors of inflammation. The chaperone protein ERdj5 is an ER-resident disulfide reductase, required for the translocation of misfolded proteins during ER-associated protein degradation. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00506DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438897PMC
March 2019
1 Read

The Role of Exosome in Autoimmune Connective Tissue Disease.

Ann Med 2019 Apr 9:1-15. Epub 2019 Apr 9.

a Departments of Dermatology , Peking Union Medical College Hospital, Chinese Academy of Medical Sciences , Beijing , China , 100730.

Exosomes have generated significant interest in the last few decades owing to their important roles in a diverse range of biological pathways. They are nano-sized lipid bilayer membrane vesicles of endosomal origin, and are produced by a vast number of cell types. They are released into the extracellular environment and are found in most biological fluids. Read More

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http://dx.doi.org/10.1080/07853890.2019.1592215DOI Listing
April 2019
1 Read
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The pipeline of targeted therapies under clinical development for primary Sjögren's syndrome: A systematic review of trials.

Autoimmun Rev 2019 Apr 6. Epub 2019 Apr 6.

Service de rhumatologie, Hôpitaux Universitaires de Strasbourg, F-67000 Strasbourg, France.; RESO : Centre de Référence des Maladies Autoimmunes Systémiques Rares Est Sud-Ouest, France; INSERM UMR_S1109, Université de Strasbourg, F-67000 Strasbourg, France. Electronic address:

To date, no immunomodulatory drug has proved efficacious in primary Sjögren's syndrome (pSS). In pSS, difficulties in drug efficacy assessment is related to the large spectrum of clinical involvements (glandular/extraglandular involvement), to the lack of correlation between symptoms of dryness and glandular function assessed by objective measurements, as well as between symptoms and systemic complications of the disease. Severe organ manifestations are generally treated by off-label therapies in accordance with current practice and guidelines for Systemic Lupus Erythematosus or other connective-tissue diseases. Read More

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http://dx.doi.org/10.1016/j.autrev.2018.12.008DOI Listing
April 2019
1 Read

Targeted TNF-α Overexpression Drives Salivary Gland Inflammation.

J Dent Res 2019 Apr 8:22034519837240. Epub 2019 Apr 8.

1 National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.

Chronic inflammation of the salivary glands from pathologic conditions such as Sjögren's syndrome can result in glandular destruction and hyposalivation. To understand which molecular factors may play a role in clinical cases of salivary gland hypofunction, we developed an aquaporin 5 (AQP5) Cre mouse line to produce genetic recombination predominantly within the acinar cells of the glands. We then bred these mice with the TNF-αglo transgenic line to develop a mouse model with salivary gland-specific overexpression of TNF-α; which replicates conditions seen in sialadenitis, an inflammation of the salivary glands resulting from infection or autoimmune disorders such as Sjögren's syndrome. Read More

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http://dx.doi.org/10.1177/0022034519837240DOI Listing
April 2019
2 Reads

Clinical manifestations, immunological features and prognosis of Chinese pediatric systemic lupus erythematosus: A single-center study.

Int J Rheum Dis 2019 Apr 8. Epub 2019 Apr 8.

Department of Nephrology and Rheumatology, Shanghai Children's Medical Center, Shanghai Jiaotong University School of Medicine, Shanghai, China.

Aim: Since there are only a few reports on pediatric systemic lupus erythematosus (pSLE) in Chinese populations, therefore we retrospectively report the clinical and immunological features as well as renal outcome in Chinese pSLE.

Methods: Patients diagnosed with pSLE at Shanghai Children's Medical Center between 2001 and 2016 were evaluated and clinical data were retrospectively collected.

Results: A total of 102 pSLE patients were analyzed. Read More

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http://dx.doi.org/10.1111/1756-185X.13547DOI Listing
April 2019
1 Read

[The importance of microRNAs in the development of systemic autoimmune disorders].

Orv Hetil 2019 Apr;160(15):563-572

Belgyógyászati Intézet, Klinikai Immunológiai Tanszék, Debreceni Egyetem, Általános Orvostudományi Kar Debrecen, Móricz Zs. krt. 22., 4032.

MicroRNAs (miRNAs) are 18-25 nucleotide long, single stranded, endogenous, non-coding small RNAs playing an important role in regulating gene expression at posttranscriptional level. miRNAs control approximately 90% of protein-coding genes, and play a central role in various biological processes including immune cell lineage commitment, differentiation, proliferation, apoptosis and maintenance of immune homeostasis. Changes in the expression of certain miRNAs may lead to the development of many diseases, including systemic autoimmune diseases. Read More

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http://dx.doi.org/10.1556/650.2019.31349DOI Listing
April 2019
1 Read

Successful Treatment of Sjögren's Syndrome Presenting as a Condition Similar to Chronic Capillary Leak Syndrome Using Combination Therapy with High-Dose Intravenous Immunoglobulin and Glucocorticoid.

Case Rep Rheumatol 2019 4;2019:4865024. Epub 2019 Mar 4.

Department of Rheumatology, Ome Municipal General Hospital, Ome, Japan.

A 70-year-old woman with Sjögren's syndrome (SS) complained of generalized edema. Computed tomography showed thoracoabdominal fluid, suggesting serositis with SS. 35 mg/day of prednisolone as a monotherapy was ineffective. Read More

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http://dx.doi.org/10.1155/2019/4865024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425372PMC
March 2019
2 Reads

IL-10-producing regulatory B cells restrain the T follicular helper cell response in primary Sjögren's syndrome.

Cell Mol Immunol 2019 Apr 4. Epub 2019 Apr 4.

Department of Pathology and Shenzhen Institute of Research and Innovation, The University of Hong Kong, Hong Kong, China.

Increased numbers of T follicular helper (Tfh) cells have been implicated in the development of autoimmune diseases including primary Sjögren's syndrome (pSS), but how the Tfh cell response is regulated during autoimmune pathogenesis remains largely unclear. Here, we first found negative correlations between IL-10 regulatory B (Breg) cell numbers and Tfh cell responses and disease activity in patients with pSS and mice with experimental Sjögren's syndrome (ESS). Moreover, we detected high expression of IL-10 receptor on Tfh cells and their precursors in both humans and mice. Read More

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http://dx.doi.org/10.1038/s41423-019-0227-zDOI Listing

Rheumatologic Diseases and the Liver.

Clin Liver Dis 2019 May 8;23(2):247-261. Epub 2019 Mar 8.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Howard University Hospital and College of Medicine, 2041 Georgia Avenue Northwest, Suite 5C02, Washington, DC 20060, USA. Electronic address:

A variety of rheumatologic disorders may affect the liver. There is a significant epidemiologic, genetic, and immunologic overlap between immune-mediated rheumatologic disorders and autoimmune liver diseases. There is an increased frequency of autoimmune liver diseases, such as primary biliary cholangitis, autoimmune hepatitis, primary sclerosing cholangitis, or overlap syndrome, in patients with systemic lupus erythematosus, rheumatoid arthritis, Sjögren syndrome, systemic sclerosis, vasculitis, and other immune-related diseases. Read More

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http://dx.doi.org/10.1016/j.cld.2018.12.007DOI Listing
May 2019
1 Read

Risk of Parkinson disease in Sjögren syndrome administered ineffective immunosuppressant therapies: A nationwide population-based study.

Medicine (Baltimore) 2019 Apr;98(14):e14984

Department of Medical Research, China Medical University HsinChu Hospital, HsinChu County, China Medical University.

To determine the incidence and risk of Parkinson disease (PD) in patients with Sjögren syndrome (SS) according to a nationwide population-based database.In total, 12,640 patients in the SS cohort and 50,560 in the non-SS cohort were enrolled from Taiwan's National Health Insurance Research Database from 2000 to 2010. We used the Cox multivariable proportional hazards model to determine the risk factors for PD in the SS cohort. Read More

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http://dx.doi.org/10.1097/MD.0000000000014984DOI Listing
April 2019
3 Reads

The role of stroma and epithelial cells in primary Sjögren's syndrome.

Rheumatology (Oxford) 2019 Mar 3. Epub 2019 Mar 3.

Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK.

Primary SS (pSS) is a chronic autoimmune condition characterized by infiltration of the exocrine glands and systemic B cell hyperactivation. This glandular infiltration is associated with loss of glandular function, with pSS patients primarily presenting with severe dryness of the eyes and mouth. Within the affected glands, the infiltrating lymphocytes are organized in tertiary lymphoid structures. Read More

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http://dx.doi.org/10.1093/rheumatology/kez050DOI Listing
March 2019
2 Reads

Blocking CD40-CD40L interactions in Sjögren syndrome.

Authors:
Jessica McHugh

Nat Rev Rheumatol 2019 Apr 3. Epub 2019 Apr 3.

Nature Reviews Rheumatology, .

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http://dx.doi.org/10.1038/s41584-019-0215-9DOI Listing
April 2019
1 Read

Methods for type I interferon detection and their relevance for clinical utility and improved understanding of rheumatic diseases.

Clin Exp Rheumatol 2019 Mar 25. Epub 2019 Mar 25.

Department of Paediatrics, Division of Rheumatology, The University of British Columbia, and BC Children's Hospital Research Institute, Vancouver, Canada.

Type I interferons (IFN) are a class of inducible and protective cytokines best known for immune defence against viruses and intracellular bacteria. Inappropriate stimulation or defective negative regulation of type I IFN expression however can lead to persistent type I IFN activity with detrimental effects. This is particularly relevant for a class of monogenic autoinflammatory diseases ("type I interferonopathies"), along with many other complex rheumatic diseases such as systemic lupus erythematosus (SLE), dermatomyositis (DM), systemic sclerosis (SSc), rheumatoid arthritis (RA) and Sjögren's syndrome (SS). Read More

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March 2019
7 Reads

Are antibodies against La (SSB) no longer useful for the diagnosis of Sjögren's syndrome?

Clin Exp Rheumatol 2019 Apr 2. Epub 2019 Apr 2.

Division of Clinical Immunology and Allergy, Department of Medical Specialties, University Hospital and School of Medicine, Geneva, Switzerland.

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April 2019
2 Reads

Protein-losing gastroenteropathy in a patient with concomitant systemic lupus erythematosus and Sjögren's syndrome.

Immunol Med 2018 Mar 3;41(1):34-38. Epub 2018 Apr 3.

g Division of Advanced Preventive Medical Sciences, Department of Immunology and Rheumatology , Nagasaki University Graduate School of Biomedical Sciences , Nagasaki , Japan.

We report a female in her twenties who developed generalized edema. She was diagnosed as systemic lupus erythematous (SLE) and Sjögren's syndrome (SS) based on her physical manifestations and positive findings for antinuclear antibody and anti-SS-A/SS-B-antibody. Although she manifested hypoproteinemia, a possibility of lupus nephritis was denied due to a lack of significant abnormality in kidney function tests and urinalysis. Read More

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http://dx.doi.org/10.1080/09114300.2018.1451614DOI Listing
March 2018
1 Read

[Sjögren's syndrome].

Authors:
Torsten Witte

Z Rheumatol 2019 Apr 1. Epub 2019 Apr 1.

Klinik für Immunologie und Rheumatologie, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625, Hannover, Deutschland.

The prevalence of primary Sjögren's syndrome (pSS) is between 1:100 and 1:1000 and it is therefore the most common connective tissue disease. Nevertheless, it can be difficult to diagnose pSS as the symptoms are frequently unspecific and diagnostic markers are lacking in many patients. In addition, only few controlled therapeutic studies of pSS have been carried out so that the optimal management is not yet clear. Read More

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http://dx.doi.org/10.1007/s00393-019-0625-8DOI Listing
April 2019
1 Read

T Cell-Specific PTPN2-Deficiency in NOD Mice Accelerates the Development of Type 1 Diabetes and Autoimmune Co-Morbidities.

Diabetes 2019 Apr 1. Epub 2019 Apr 1.

Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia,

Genome-wide association studies have identified as an important non-major histocompatibility complex gene for autoimmunity. Single nucleotide polymorphisms that reduce expression have been linked with the development of varied autoimmune disorders, including type 1 diabetes. The tyrosine-phosphatase PTPN2 attenuates T cell receptor and cytokine signalling in T cells to maintain peripheral tolerance, but the extent to which PTPN2-deficiency in T cells might influence type 1 diabetes onset remains unclear. Read More

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http://dx.doi.org/10.2337/db18-1362DOI Listing
April 2019
5 Reads

Meta-analysis on pharmacological therapies in the management of xerostomia in patients with Sjogren's syndrome.

Immunopharmacol Immunotoxicol 2019 Apr 1:1-7. Epub 2019 Apr 1.

b Department of Oral Medicine and Radiology , Government Dental College and Hospital , Hyderabad , India.

Introduction: Sjogren's syndrome is an immunologic disorder, characterized by symptoms of dry mouth and dry eyes. Management of xerostomia is more difficult and challenging, various pharmacologic agents have been tried and evaluated in the management of xerostomia in these patients, but the results were inconsistent and variable. Hence, the present study is aimed at evaluation and comparison of different pharmacological agents in the management of xerostomia in patients with Sjogren's syndrome. Read More

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http://dx.doi.org/10.1080/08923973.2019.1593448DOI Listing
April 2019
1 Read

Acquired Gitelman Syndrome Associated with Systemic Sclerosis.

Cureus 2019 Jan 20;11(1):e3923. Epub 2019 Jan 20.

Internal Medicine, Einstein Medical Center, Philadelphia, USA.

Gitelman syndrome is an inherited renal disorder characterized by hypomagnesemia, hypokalemia, hypocalciuria and metabolic alkalosis linked to the genes encoding the thiazide sensitive NaCl cotransporter (NCCT) located on the distal convoluted tubule of the kidney. It usually presents in late childhood or early adulthood with electrolyte abnormalities resembling chronic thiazide diuretic use. Acquired Gitelman syndrome is a very rare disorder mostly associated with Sjogren's syndrome. Read More

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http://dx.doi.org/10.7759/cureus.3923DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430306PMC
January 2019
4 Reads

[Clinical Pharmaceutical Research Based on New Proteome Analysis Based on Chromatographic Separation].

Authors:
Kaname Ohyama

Yakugaku Zasshi 2019 ;139(4):505-509

Graduate School of Biomedical Sciences, Nagasaki University.

Comprehensive identification of antigens in immune complexes (IC-antigens) is beneficial to provide insights into pathophysiology and could form the basis for novel diagnostic and treatment strategies for many immune-related diseases. Immune complexome analysis is a method for comprehensively identifying and profiling IC-antigens in biological fluids (such as serum and cerebrospinal fluid). We applied this strategy to the analysis of circulating ICs in autoimmune diseases (rheumatoid arthritis, Sjögren's syndrome, systemic scleroderma, and systemic lupus erythematosus), infectious diseases, and cancers. Read More

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https://www.jstage.jst.go.jp/article/yakushi/139/4/139_18-00
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http://dx.doi.org/10.1248/yakushi.18-00167DOI Listing
April 2019
5 Reads

The combination of whole-exome sequencing and clinical analysis allows better diagnosis of rare syndromic retinal dystrophies.

Acta Ophthalmol 2019 Mar 29. Epub 2019 Mar 29.

Department of Ophthalmology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.

Purpose: To identify the accurate clinical diagnosis of rare syndromic inherited retinal diseases (IRDs) based on the combination of clinical and genetic analyses.

Methods: Four unrelated families with various autosomal recessive syndromic inherited retinal diseases were genetically investigated using whole-exome sequencing (WES).

Results: Two affected subjects in family MOL0760 presented with a distinctive combination of short stature, developmental delay, congenital mental retardation, microcephaly, facial dysmorphism and retinitis pigmentosa (RP). Read More

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http://dx.doi.org/10.1111/aos.14095DOI Listing
March 2019
3 Reads

Tolerability and safety of long-term rituximab treatment in systemic inflammatory and autoimmune diseases.

Rheumatol Int 2019 Mar 28. Epub 2019 Mar 28.

Clinical Immunology Unit, Stavanger University Hospital, Stavanger, Norway.

Rituximab, an anti-CD20 monoclonal antibody causing selective B-cell depletion, is used for various systemic inflammatory and autoimmune diseases (SIADs). Long-term safety data on rituximab are limited. The objectives of this study were to evaluate the long-term safety and tolerability of rituximab treatment for SIADs. Read More

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http://dx.doi.org/10.1007/s00296-019-04272-1DOI Listing
March 2019
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SNP variations in IL10, TNFα and TNFAIP3 genes in patients with dry eye syndrome and Sjogren's syndrome.

J Inflamm (Lond) 2019 18;16. Epub 2019 Mar 18.

2Department of Ophthalmology, Hadassah-Hebrew University Medical Center, POB 12000, 91120 Jerusalem, Israel.

Background: Cytokines are known to be key players in dry eye syndrome (DES) and Sjogren's syndrome (SS) pathogenesis. In this study we compared single nucleotide polymorphism (SNP) variations in genes encoding cytokine levels among SS and DES patients in Israel.

Methods: We recruited 180 subjects, 82 with SS and 98 with DES. Read More

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http://dx.doi.org/10.1186/s12950-019-0209-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421669PMC
March 2019
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Soluble siglec-5 is a novel salivary biomarker for primary Sjogren's syndrome.

J Autoimmun 2019 Mar 25. Epub 2019 Mar 25.

Division of Rheumatology, Department of Internal Medicine, Seoul St Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea; The Rheumatism Research Center, Catholic Research Institute of Medical Science, The Catholic University of Korea, Seoul, Republic of Korea. Electronic address:

Despite advances in the understanding of the pathogenesis, disease-specific biomarkers have not been included in the classification criteria for Primary Sjogren's syndrome (pSS). Based on a microarray of peripheral blood mononuclear cells (PBMCs) from patients with primary Sjogren's syndrome (pSS), we aimed to investigate whether soluble sialic acid-binding immunoglobulin-like lectin (siglec)-5 in saliva might be a biomarker for pSS. The concentration of siglec-5 in saliva and sera was determined by ELISA. Read More

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http://dx.doi.org/10.1016/j.jaut.2019.03.008DOI Listing
March 2019
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Primary antiphospholipid syndrome during aromatase inhibitors therapy: A case report and review of the literature.

Medicine (Baltimore) 2019 Mar;98(13):e15052

Rheumatology Unit, Department of Medicine, Surgery and Neurosciences, Azienda Ospedaliera Universitaria Senese.

Rationale: Aromatase inhibitors (AIs) are a class of drugs widely used in the treatment of estrogen sensitive breast and ovarian cancer which convert testosterone to estradiol and androstenedione to estrogen. The AIs of third generation, including anastrazole, letrozole and exemestane, have actually become the standard of care of estrogen-receptor-positive breast cancer in menopausal women and are recommended as adjuvant treatment after surgery in place of/or following tamoxifen. Their main side-effects include reduction in bone mineral density, occurrence of menopausal manifestations and development of musculoskeletal symptoms which are, usually, transient, but sometimes evolve into a typical form of arthritis, such as rheumatoid arthritis (RA). Read More

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http://dx.doi.org/10.1097/MD.0000000000015052DOI Listing
March 2019
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Oral epithelial membrane-associated mucins and transcriptional changes with Sjögren's syndrome.

Oral Dis 2019 Mar 28. Epub 2019 Mar 28.

Department of Oral Biology, College of Dentistry, University of Florida, Gainesville, Florida.

Objectives: To determine expression and localization of membrane-associated mucins within human keratinized and non-keratinized oral epithelia, and to explore transcriptional changes associated with primary Sjögren's syndrome.

Subjects And Methods: Mucin transcripts and glycoproteins were determined by RT-PCR and immunohistochemistry, respectively, in oral keratinized (hard palate) and non-keratinized (buccal) epithelia obtained from three cadavers. Mucin transcripts assessed by quantitative PCR were compared between cells harvested by brushing buccal and palatal epithelia of 25 female primary Sjögren's syndrome patients vs 25 healthy age-matched female control subjects. Read More

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http://dx.doi.org/10.1111/odi.13098DOI Listing
March 2019
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Comparison of the meibomian gland dysfunction in patients with chronic ocular graft-versus-host disease and Sjögren's syndrome.

Int J Ophthalmol 2019 18;12(3):393-400. Epub 2019 Mar 18.

Department of Ophthalmology and Research Institute of Medical Sciences, Chonnam National University Medical School and Hospital, Gwangju 501-757, South Korea.

Aim: To investigate the abnormalities in the meibomian gland in patients with dry eye disease (DED) associated with chronic ocular graft-versus-host disease (coGVHD) in comparison with Sjögren's syndrome (SS), a major form of aqueous deficient DED and meibomian gland dysfunction (MGD), a common cause of evaporative DED.

Methods: A total 135 eyes of 135 subjects included in this study: patients with DED associated with coGVHD (=30), patients with SS (=35), patients with MGD (=35), and normal controls (=35). All participants completed the Ocular Surface Disease Index (OSDI) questionnaire, ocular surface examination [Schirmer test, tear film breakup time (TFBUT), and ocular surface staining], and meibomian gland assessment [meiboscore (gland dropout detected on meibography using infrared camera of the Keratograph 5M), meibum expressibility score (MES), meibum quality score (MQS), lid margin abnormality]. Read More

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http://dx.doi.org/10.18240/ijo.2019.03.07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423382PMC
March 2019
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Increased risk of thyroid disease in patients with Sjogren's syndrome: a systematic review and meta-analysis.

PeerJ 2019 19;7:e6737. Epub 2019 Mar 19.

Department of Endocrinology and Metabolism, People's Hospital of Liaoning Province, Shenyang, China.

Background: Sjogren's syndrome (SS) is a chronic autoimmune epithelitis characterized by disruption of epithelial cells, ensuing lymphoplasmocytic infiltration of exocrine glands, and subsequent dryness of the mouth and eyes. Individuals with SS are more likely to have the thyroid disease. However, this association remains controversial. Read More

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http://dx.doi.org/10.7717/peerj.6737DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430100PMC
March 2019
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[Marrow megakaryocyte count as a response predictor of severe thrombocytopenia in patients with primary Sjögren syndrome].

Zhonghua Nei Ke Za Zhi 2019 Apr;58(4):282-287

Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.

To explore the predictive factors for determining the therapeutic response and prognosis of severe thrombocytopenia (TP) in patients with primary Sjögren syndrome(pSS). Patients with pSS and severe TP (platelet count ≤ 50×10(9)/L) admitted between 2010 to 2016 at Peking Union Medical College Hospital were classified according to their therapeutic response and analyzed retrospectively. The response parameters and clinical data including bone marrow aspiration results and laboratory findings were collected. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0578-1426.2019.04.009DOI Listing
April 2019
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Diagnostic Utility of Separate Anti-Ro60 and Anti-Ro52/TRIM21 Antibody Detection in Autoimmune Diseases.

Front Immunol 2019 12;10:444. Epub 2019 Mar 12.

Laboratory of Dermatology, Faculty of Medicine, University of Reims Champagne-Ardenne, Reims, France.

Anti-SS-A antibodies are often sought for in autoimmune diseases diagnosis. Two different target proteins have actually been identified: Ro52 and Ro60. Clinical and immunological associations seem different depending on anti-Ro52 or anti-Ro60 antibodies presence. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00444DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423153PMC
March 2019
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The Fatigue Assessment Scale as a simple and reliable tool in systemic lupus erythematosus: a cross-sectional study.

Arthritis Res Ther 2019 Mar 25;21(1):80. Epub 2019 Mar 25.

Division of Immunology and Allergy, Department of Medicine, Centre Hospitalier Universitaire Vaudois, CHUV BH09-627, CH-1011, Lausanne, Switzerland.

Background: The vast majority of patients with systemic lupus erythematosus (SLE) complain about fatigue. They also report fatigue as one of their most debilitating symptoms. Yet, in clinical practice, fatigue is only rarely assessed and remains poorly understood. Read More

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https://arthritis-research.biomedcentral.com/articles/10.118
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http://dx.doi.org/10.1186/s13075-019-1864-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434822PMC
March 2019
5 Reads

High-Risk Indicators of Renal Involvement in Primary Sjogren's Syndrome: A Clinical Study of 1002 Cases.

J Immunol Res 2019 17;2019:3952392. Epub 2019 Feb 17.

Division of Nephrology, Department of Medicine, The Second Hospital of Shanxi Medical University, Taiyuan, Shanxi 030001, China.

Objective: A retrospective analysis of clinical characteristics and immunological manifestations of primary Sjogren's syndrome (pSS) patients with or without renal involvement was conducted in order to elucidate the potential risk factors of renal damage in pSS and evaluate the condition.

Methods: A total of 1002 patients, who fulfilled the 2002 classification criteria for pSS from the Second Affiliated Hospital of Shanxi Medical University, were enrolled in the cross-sectional study. Clinical, immunological, and histological characteristics were compared between pSS patients with and without renal involvement, and potential risk factors of renal involvements in pSS patients were examined by multivariate analysis. Read More

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http://dx.doi.org/10.1155/2019/3952392DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397987PMC
February 2019
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Predictors of blood transfusion and in-hospital outcomes in patients with gastric antral vascular ectasia (GAVE): a nationwide population-based analysis.

Ann Transl Med 2019 Feb;7(3):46

Department of Internal Medicine, Mercer University School of Medicine, Macon, GA, USA.

Background: Gastric antral vascular ectasia (GAVE) is a rare cause of chronic non-variceal upper gastrointestinal (GI) bleeding and can turn into life-threatening bleed in some patients. Packed red blood cell (PRBC) transfusions are often required in these patients during hospitalization. We aimed to investigate the hospitalization outcomes and predictors of PRBC transfusions in patients with GAVE lesions. Read More

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http://dx.doi.org/10.21037/atm.2019.01.11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389573PMC
February 2019
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Correlation of clinical symptoms and signs with conjunctival gene expression in primary Sjögren syndrome dry eye patients.

Ocul Surf 2019 Mar 21. Epub 2019 Mar 21.

Sorbonne Universités, UPMC Univ Paris 06, INSERM, CNRS, Institut de la Vision, Paris, France; Université Sorbonne Paris Cité USPC, Université Paris Descartes, Faculté de Pharmacie de Paris, France.

Purpose: The aim of this study was to characterize the expression of inflammation-related genes on the ocular surface of Sjögren syndrome (SS) patients and to evaluate their correlations with clinical symptoms and signs.

Methods: The study enrolled 30 patients with SS dry eye and 15 healthy controls. Symptoms were evaluated using OSDI questionnaire. Read More

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http://dx.doi.org/10.1016/j.jtos.2019.03.005DOI Listing
March 2019
4 Reads

Blockade of CD40-CD154 pathway interactions suppresses ectopic lymphoid structures and inhibits pathology in the NOD/ShiLtJ mouse model of Sjögren's syndrome.

Ann Rheum Dis 2019 Mar 22. Epub 2019 Mar 22.

Department of Autoimmunity, Transplantation and Inflammation, Novartis Institutes for BioMedical Research Basel, Basel, Switzerland

Objective: To examine the role of CD40-CD154 costimulation and effects of therapeutic pathway blockade in the non-obese diabetic (NOD/ShiLtJ) model of Sjögren's syndrome (SS).

Methods: We assessed leucocyte infiltration in salivary glands (SGs) from NOD/ShiLtJ mice by immunohistochemistry and examined transcriptomics data of SG tissue from these animals for evidence of a CD40 pathway gene signature. Additionally, we dosed MR1 (anti-CD154 antibody) in NOD mice after the onset of SS-like disease and examined the effects of MR1 treatment on sialadenitis, autoantibody production, SG leucocyte infiltration, gene expression downstream of CD40 and acquaporin 5 (AQP5) expression. Read More

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http://dx.doi.org/10.1136/annrheumdis-2018-213929DOI Listing
March 2019
1 Read