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    Salivary epidermal growth factor concentrations in patients with Sjögren syndrome and laryngopharyngeal reflux.
    Ear Nose Throat J 2017 Jun;96(6):E6-E11
    Department of Otolaryngology, Santa Casa School of Medicine and Hospitals, Av. Vereador José Diniz 3457, cj 501, São Paulo, Brazil.
    Sjögren syndrome was chosen as a clinical model to study acinar salivary deficiencies in the development of laryngopharyngeal reflux (LPR). The objective of this prospective cohort study was to compare salivary epidermal growth factor (EGF) concentrations of patients with Sjögren syndrome with and without LPR and gastroesophageal reflux disease (GERD) with normal controls. LPR was diagnosed with positive scores on the Reflux Symptom Index and Reflux and Reflux Finding Score, corroborated by esophagogastroduodenoscopy and/or 24-hour pH-metry. Read More

    Pharmacological Rescue of Ductal CFTR Rescue Pancreatic and Salivary glands Acinar Cells and Tissue Function in Mouse Models of Autoimmune diseases.
    Gastroenterology 2017 Jun 17. Epub 2017 Jun 17.
    Molecular Physiology and Therapeutics Branch, NIH, National Institute of Dental and Craniofacial Research, Bethesda MD,. Electronic address:
    Background & Aims: Sjögren's syndrome and autoimmune pancreatitis (AIP) are disorders with decreased function of salivary, lacrimal glands, and the exocrine pancreas. NOD/ShiLTJ mice and mice transduced with the cytokine BMP6 develop Sjögren's syndrome and chronic pancreatitis and MRL/Mp mice are models of AIP. CFTR is a ductal Cl(-) channel essential for ductal fluid and HCO3(-) secretion. Read More

    Ultrarapid Measurement of Diagnostic Antibodies by Magnetic Capture of Immune Complexes.
    Sci Rep 2017 Jun 19;7(1):3818. Epub 2017 Jun 19.
    Sjögren's Syndrome and Salivary Gland Dysfunction Unit, NIDCR, NIH, Bethesda, MD, United States.
    Rapid point-of-care, antibody-based testing is not currently available for the diagnosis of most autoimmune and infectious diseases. Here we report a simple, robust and ultrafast fluid-phase immunocapture method for clinical measurements of antibody levels. This method employs neodymium magnetic sticks that capture protein A/G-coated paramagnetic beads bound to antibody-luciferase-labeled antigen complexes. Read More

    Juvenile- and adult-onset systemic lupus erythematosus: a comparative study in a large cohort from the Spanish Society of Rheumatology Lupus Registry (RELESSER).
    Clin Exp Rheumatol 2017 Jun 12. Epub 2017 Jun 12.
    Department of Rheumatology, Complexo Hospitalario Universitario de Vigo, Instituto de Investigación Sanitaria Galicia Sur (IISGS), Vigo, Spain.
    Objectives: We aimed to describe juvenile-onset systemic lupus erythematosus (jSLE) features and to establish its differences compared to adult-onset SLE (aSLE) from a large national database.

    Methods: Data from patients (≥4 ACR criteria) included in Spanish Society of Rheumatology Lupus Registry (RELESSER) were analysed. Sociodemographic, clinical, serological, activity, treatment, cumulative damage, comorbidities and severity data were collected. Read More

    Elevated CCL25 and CCR9-Expressing T Helper Cells in Salivary Glands of Primary Sjögren's Syndrome Patients: Potential New Axis in Lymphoid Neogenesis.
    Arthritis Rheumatol 2017 Jun 16. Epub 2017 Jun 16.
    Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands.
    Introduction T follicular helper (Tfh)-cells play a critical role in germinal center formation and B-cell activation, both hallmarks of primary Sjögren's syndrome (pSS). CCR9-expressing Th-cells have "Tfh-like" characteristics and are increased at mucosa-associated sites in several inflammatory conditions. Because of their unique characteristics and limited evaluation we investigated the local and systemic CCL25/CCR9-axis in pSS. Read More

    cDNA microarray analysis identifies NR4A2 as a novel molecule involved in the pathogenesis of Sjögren's syndrome.
    Clin Exp Immunol 2017 Jun 16. Epub 2017 Jun 16.
    Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Japan.
    Objective: To examine genes expressed specifically in labial salivary glands (LSGs) of patients with Sjögren's syndrome (SS) in comparison with those of patients with IgG4-related disease (IgG4-RD) and to identify the genes involved in the pathogenesis of SS.

    Methods: Gene expression in LSGs of SS patients, IgG4-RD patients and healthy controls (HC) was analyzed by cDNA microarray. Quantitative PCR (qPCR) was used to validate the up-regulation of differentially expressed genes (DEGs) in SS. Read More

    Depression in primary Sjögren's syndrome: a systematic review and meta-analysis.
    Psychol Health Med 2017 Jun 16:1-12. Epub 2017 Jun 16.
    a Department of Nursing , The Second Affiliated Hospital of Nantong University , Nantong , China.
    There is substantial uncertainty regarding the prevalence of depression in Primary Sjögren's syndrome (pSS). We conducted a systematic review aiming to evaluate the association of pSS with depression. PubMed, Web of Science, VIP, CNKI and Wanfang database were searched to find the published literatures (from these databases established to October 2016). Read More

    Oxidative T Cell Modifications in Lupus and Sjogren's Syndrome.
    Lupus (Los Angel) 2017 Apr 10;2(1). Epub 2017 Jan 10.
    Department of Medicine, University of Michigan, Ann Arbor MI, USA.
    Objectives: Lupus flares are triggered by environmental agents that cause oxidative stress, but the mechanisms involved are unclear. The flares are characterized by oxidative modifications of proteins by 4-hydroxynonenals, malondialdehydes, carbonyls and nitration. These modifications have been proposed to induce and perpetuate lupus flares by "altered self" mechanisms. Read More

    The Diagnosis and Treatment of Sjögren's Syndrome.
    Dtsch Arztebl Int 2017 May;114(20):354-361
    Charité Center for Internal Medicine, Medical Department-Division of Rheumatology and Clinical Immunology, Berlin, Germany; University Clinic of Rheumatology, Immunology and Allergology, Inselspital Bern, Bern, Switzerland; BfA Wendelstein Rehabilitation Clinic, Rheumatology Center, AHB Clinic, Bad Aibling, Germany; Department of Ophthalmology, Charité Campus Virchow, Berlin, Germany; Oral Surgery, The School of Dentistry, University of Birmingham, United Kingdom.
    Background: Sjögren's syndrome is one of the more common inflammatory rheumatological diseases, with a prevalence of at least 0.4% in Germany.

    Methods: This review is based on pertinent articles retrieved by a selective search in PubMed. Read More

    Graft versus host disease: what should the oculoplastic surgeon know?
    Curr Opin Ophthalmol 2017 Jun 8. Epub 2017 Jun 8.
    University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
    Purpose Of Review: To provide a concise review of the oculoplastic manifestations of ocular graft versus host disease (GVHD), and to discuss their management.

    Recent Findings: Ocular GVHD occurs as a common immune-mediated complication of hematopoietic stem cell transplantation that presents as a Stevens-Johnson-like syndrome in the acute phase or a Sjögren-like syndrome in the chronic phase. Cicatricial conjunctivitis may be underreported in ocular GVHD. Read More

    [Pediatric salivary gland tumors and tumor-like lesions].
    Pathologe 2017 Jun 9. Epub 2017 Jun 9.
    Klinik für Hals‑, Nasen- und Ohrenheilkunde (HNO), Klinikum Augsburg, Sauerbruchstraße 6, 86156, Augsburg, Deutschland.
    Salivary gland tumors and tumor-like lesions in the pediatric population are uncommon. They comprise a heterogeneous group of infectious/inflammatory and neoplastic conditions. Pediatric salivary neoplasms include benign tumors of mesenchymal or epithelial origin as well as malignancies of epithelial (carcinomas), mesenchymal (sarcoma) or hematolymphoid (lymphoma) derivation. Read More

    Toll-like receptor 7 is overexpressed in the bladder of Hunner-type interstitial cystitis, and its activation in the mouse bladder can induce cystitis and bladder pain.
    Pain 2017 May 6. Epub 2017 May 6.
    aDepartment of Continence Medicine, The University of Tokyo Graduate School of Medicine, Tokyo, JapanbDepartment of Urology, Sapporo Medical University School of Medicine, Sapporo, JapancDepartment of Obstetrics and Gynecology, Institute for Clinical Medicine, Aarhus University, Aarhus, DenmarkdDepartment of Urology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan.
    Toll-like receptor 7 (TLR7) is associated with the pathophysiology of systemic lupus erythematosus and Sjögren syndrome, well-known diseases accompanying interstitial cystitis (IC). We studied TLR7 expression in the bladder of patients with Hunner-type IC (HIC) and its functional roles in bladder inflammation and nociception using mice. Bladder biopsy specimens were obtained from patients with HIC. Read More

    Exocrine Gland Morphogenesis: Insights into the Role of Amphiregulin from Development to Disease.
    Arch Immunol Ther Exp (Warsz) 2017 Jun 7. Epub 2017 Jun 7.
    Section of Human Anatomy and Histology, Laboratory of Cell Biology, Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari "Aldo Moro", Piazza Giulio Cesare 1, 70124, Bari, Italy.
    Amphiregulin (AREG) is a well-characterized member of the epidermal growth factor (EGF) family and is one of the ligands of the EGF receptor (EGFR). AREG plays a key role in mammalian development and in the control of branching morphogenesis in various organs. Furthermore, AREG participates in a wide range of physiological and pathological processes activating the major intracellular signalling cascades governing cell survival, proliferation and motility. Read More

    The sphingosine 1-phosphate break-down product (2E)-hexadecenal forms protein adducts and glutathione conjugates in vitro.
    J Lipid Res 2017 Jun 6. Epub 2017 Jun 6.
    University of Potsdam, Germany;
    Sphingosine 1-phosphate (S1P), a bioactive lipid involved in various physiological processes such as cell proliferation and apoptosis, can be irreversibly cleaved by the S1P lyase, yielding phosphoethanolamine and (2E)-hexadecenal (2EHD). The latter metabolite, an α,β-unsaturated fatty aldehyde, may be susceptible to nucleophilic attack by cellular biomolecules. Hence, we studied whether 2EHD forms reaction products with glutathione (GSH) and proteins in vitro Using liquid chromatography-tandem mass spectrometry (LC-MS/MS) and stable isotopically labeled reference material, we identified a total of nine novel reaction products of 2EHD in a cell-free approach: two GSH conjugates and seven L-amino acid adducts. Read More

    Effect of mesenchymal stem cells on Sjögren-like mice and the microRNA expression profiles of splenic CD4+ T cells.
    Exp Ther Med 2017 Jun 6;13(6):2828-2838. Epub 2017 Apr 6.
    Department of Rheumatology, Tongji Hospital of Tongji University, Shanghai 200065, P.R. China.
    Mesenchymal stem cells (MSCs) serve immuno-regulatory functions and offer a promising novel treatment for certain autoimmune diseases. The present study investigated the therapeutic effect of mice bone marrow (BM)-MSCs on mice with relatively late stage of Sjögren-like disease and the impact of BM-MSCs on the microRNA (miRNA) expression profiles of splenic CD4+ T cells. Female NOD/Ltj mice were randomized into two groups: The disease group (n=8) and the MSC-treated group (n=8). Read More

    Pathological Analysis of Ocular Lesions in a Murine Model of Sjögren's Syndrome.
    Int J Mol Sci 2017 Jun 6;18(6). Epub 2017 Jun 6.
    Departmant of Oral Molecular Pathology, Tokushima University Graduate School of Biomedical Sciences, Tokushima 770-8504, Japan.
    Sjögren's syndrome (SS) is a systemic autoimmune disease characterized by severe inflammation of exocrine glands such as the salivary and lacrimal glands. When it affects the lacrimal glands, many patients experience keratoconjunctivitis due to severely dry eyes. This study investigated the pathological and immunological characteristics of ocular lesions in a mouse model of SS. Read More

    Combined interventional sialendoscopy and intraductal steroid therapy for recurrent sialadenitis in Sjögren's syndrome. Results of a pilot monocentric trial.
    Clin Otolaryngol 2017 Jun 5. Epub 2017 Jun 5.
    Otolaryngology Unit; Department of Clinical Sciences and Community Health, University of Milan; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
    Objectives: To evaluate the effectiveness of interventional sialendoscopy alone or combined with outpatient intraductal steroid irrigations in patients with sialoadenitis due to Sjögren's syndrome (SS).

    Design: A pilot therapeutic study.

    Setting: ENT Clinics, Universities of Milan and Pavia. Read More

    Mesenchymal stem cells for treating autoimmune dacryoadenitis.
    Stem Cell Res Ther 2017 Jun 5;8(1):126. Epub 2017 Jun 5.
    Tianjin Medical University Eye Hospital, Tianjin Medical University Eye Institute & Tianjin Medical University School of Optometry and Ophthalmology, No.251 Fukang Road, Nankai District, Tianjin, 300384, People's Republic of China.
    Autoimmune dacryoadenitis, such as Sjögren syndrome, comprises multifactorial and complex diseases. Inflammation of the lacrimal gland plays a key role in the pathogenesis of diseases. Unfortunately, current treatment strategies, including artificial tears, anti-inflammatory drugs, punctual occlusion, and immunosuppressive drugs, are only palliative, and long-term administration of these strategies is associated with adverse effects that limit their utility. Read More

    RNAi Screen and Proteomics Reveal NXF1 as a Novel Regulator of IRF5 Signaling.
    Sci Rep 2017 Jun 2;7(1):2683. Epub 2017 Jun 2.
    Department of Physiological Sciences, Oklahoma State University, Stillwater, Oklahoma, 74078, USA.
    Interferon regulatory factor 5 (IRF5) is a key transcription factor of innate immunity, which plays an important role in host restriction to viral infection and inflammation. Genome-wide association studies have implied the association of IRF5 with several autoimmune diseases, including systemic lupus erythematosus (SLE), Sjogren's syndrome, inflammatory bowel disease and multiple sclerosis. However, the regulation of IRF5-mediated immunity is not well understood. Read More

    Ectopic germinal center and megalin defect in primary Sjogren syndrome with renal Fanconi syndrome.
    Arthritis Res Ther 2017 Jun 2;19(1):120. Epub 2017 Jun 2.
    Nephrology Department, Chinese Academy of Medical Science, Peking Union Medical College Hospital, Tsing Hua University, Beijing, China.
    Background: This study reports the clinical and pathological features of 12 cases of primary Sjogren syndrome (pSS) with renal involvement presenting with proximal tubular dysfunction in a single center, and investigates the possible correlation of ectopic germinal center formation and megalin/cubilin down-expression.

    Method: Clinical and pathological records were reviewed. Immunohistochemistry was carried out to detect megalin, cubilin, CD21 and IL-17 expression. Read More

    A Case of Kidney Involvement in Primary Sjögren's Syndrome.
    Am J Case Rep 2017 Jun 3;18:622-626. Epub 2017 Jun 3.
    Department of Medicine, University of California, Los Angeles, CA, USA.
    BACKGROUND Sjögren's syndrome is an autoimmune disorder caused by the infiltration of monocytes in epithelial glandular and extra-glandular tissues. Hallmark presentations include mouth and eye dryness. Although renal involvement is uncommon in primary Sjögren's syndrome (pSS), patients may experience renal tubular acidosis type I (RTA I), tubulointerstitial nephritis, diabetes insipidus (DI), nephrolithiasis, and Fanconi syndrome. Read More

    Relationship of miRNA-146a to primary Sjögren's syndrome and to systemic lupus erythematosus: a meta-analysis.
    Rheumatol Int 2017 Jun 1. Epub 2017 Jun 1.
    First Affiliated Hospital of XinJiang Medical University, Urumqi, 830011, China.
    Sjögren's syndrome (SjS) and systemic lupus erythematosus (SLE) are common systemic autoimmune diseases, which impact not only patient health but also their quality of life. miRNA-146a is a microRNA that participates in the pathophysiology of SjS and SLE. In this investigation, we conducted a meta-analysis to determine the relationship of miR-146a to primary SjS (PSS) and to SLE. Read More

    Manifestation of meibomian gland dysfunction in patients with Sjögren's syndrome, non-Sjögren's dry eye, and non-dry eye controls.
    Int Ophthalmol 2017 May 31. Epub 2017 May 31.
    Department of Ophthalmology, Chonnam National University Medical School and Hospital, 42 Jebong-ro, Dong-gu, Gwangju, 501-757, South Korea.
    Purpose: To evaluate the manifestation of meibomian gland dysfunction in patients with Sjögren's syndrome (SS), non-Sjögren's syndrome dry eye (non-SS) patients, and non-dry eye controls.

    Methods: We recruited 31 participants with SS dry eye, 30 participants with non-SS dry eye, and 35 healthy controls without dry eye symptoms. Noninvasive tear breakup time (NITBUT) and meibomian gland dropout score (meiboscore) were measured using the Oculus Keratograph 5 M. Read More

    Abatacept attenuates T follicular helper-cell-dependent B-cell hyperactivity in primary Sjögren's syndrome.
    Arthritis Rheumatol 2017 May 31. Epub 2017 May 31.
    Departments of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, The Netherlands.
    Objective To assess the effect of abatacept (CTLA-4-Ig), which limits T-cell activation, on homeostasis of CD4(+) T-cell subsets and T-cell-dependent B-cell hyperactivity in patients with primary Sjögren's syndrome (pSS). Methods Fifteen pSS patients treated with abatacept were included. Circulating CD4(+) T-cell and B-cell subsets were analyzed by flow cytometry at baseline, on treatment and off treatment. Read More

    Lymphocytes as Biomarkers of Therapeutic Response in Rheumatic Autoimmune Diseases, Is It a Realistic Goal?
    Clin Rev Allergy Immunol 2017 May 30. Epub 2017 May 30.
    Rheumatology Department, Lapeyronie Hospital and Montpellier I University, Montpellier, France.
    Many therapies are available for patients with rheumatoid arthritis (RA) while biological therapies have limited effects in patients with systemic lupus erythematosus (SLE) and primary Sjögren's syndrome (pSS). In both cases, biomarkers predicting drug response would be very useful to guide clinicians in their choice. We performed a systematic review to evaluate the value of lymphocyte phenotyping as a marker of therapeutic response. Read More

    Three cases of localized cutaneous nodular amyloidosis in patients with limited systemic sclerosis and a brief literature review.
    Int J Womens Dermatol 2017 Jun 11;3(2):91-95. Epub 2017 Jan 11.
    Department of Dermatology, University of Iowa Hospitals and Clinics, Iowa City, IA.
    Localized cutaneous nodular amyloidosis (LCNA) is the rarest form of localized cutaneous amyloidosis. In patients with LCNA, local plasma cells secrete immunoglobulin light chains called amyloid L via an unknown mechanism. LCNA has been associated with autoimmune connective tissue diseases such as most commonly Sjögren syndrome. Read More

    High Prevalence of Thyroid Disease and Role of Salivary Gland Scintigraphy in Patients with Xerostomia.
    Nucl Med Mol Imaging 2017 Jun 24;51(2):169-177. Epub 2016 Nov 24.
    Department of Nuclear Medicine, Kyungpook National University School of Medicine/Hospital, 130 Dongdeok-ro, Jung-gu, Daegu, Republic of Korea 700-721.
    Purpose: Although Sjögren's syndrome (SS) is the most common disease causing xerostomia, autoimmune thyroid diseases can also affect the salivary glands. The aim of our study was to estimate the prevalence of thyroid diseases (TD) in subjects with symptoms of xerostomia and evaluate the efficacy of salivary gland scintigraphy (SGS) in the detection of TD in patients with SS and without SS.

    Methods: We retrospectively reviewed the SGS findings of 173 subjects (men:women, 29:144) with symptoms of xerostomia. Read More

    Tear Film Stability in Sjögren Syndrome Patients Treated with Hyaluronic Acid Versus Crosslinked Hyaluronic Acid-Based Eye Drops.
    J Ocul Pharmacol Ther 2017 May 30. Epub 2017 May 30.
    1 Department of Surgery and Biomedical Science, Division of Ophthalmology, University of Perugia , S. Maria della Misericordia Hospital, Perugia, Italy .
    Purpose: To compare the stability of the tear film after instillation of eye drops containing hyaluronic acid (HA) or crosslinked hyaluronic acid (CLHA)-based in patients with Sjögren syndrome-related dry eye (SSDE).

    Methods: Forty subjects were included in this study and were divided into 2 groups: the first group (control group) consisted of 20 healthy volunteers; the second group (study group) constituted of 20 suffering from SSDE; before and 5, 30, and 60 min after instillation of eye drops the surface regularity index (SRI) and surface asymmetry index (SAI) were registered.

    Results: Comparing HA and CLHA, in the control group, SAI show statistically significant difference in the time 0 and in time 5, whereas there is no a statistically significant difference after 30 and 60 min from instillation. Read More

    Hydroxychloroquine affects bone resorption both in vitro and in vivo.
    J Cell Physiol 2017 May 30. Epub 2017 May 30.
    Department of Internal Medicine, Division of Clinical Immunology and Endocrinology and Department of Rheumatology, Erasmus Medical Center, Rotterdam, The Netherlands.
    We recently showed that patients with primary Sjögren syndrome (pSS) have significantly higher bone mineral density (BMD) compared to healthy controls. The majority of those patients (69%) was using hydroxychloroquine (HCQ), which may have favorable effects on BMD. The aim of the study was to evaluate whether HCQ modulates osteoclast function. Read More

    Characteristics of germinal center-like structures in patients with Sjögren's syndrome.
    Int J Rheum Dis 2017 Feb 5;20(2):245-251. Epub 2016 Nov 5.
    Department of Rheumatology and Immunology, Peking University People's Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis, Beijing, China.
    Aim: To analyze the relationship between ectopic germinal centers (GCs) in the salivary glands and the clinical/laboratory characteristics of patients with Sjögren's syndrome (SS).

    Methods: Retrospectively, 126 patients with primary SS (pSS) and 16 patients with secondary SS (sSS) were analyzed. Minor salivary gland biopsies were evaluated for the presence of GC-like morphology by hematoxylin and eosin (H&E) and immunohistochemical (IHC) staining for CD21. Read More

    Antiribonuclease H2 antibodies are an immune biomarker for systemic lupus erythematosus.
    Autoimmunity 2017 May 27:1-6. Epub 2017 May 27.
    a Department of Rheumatology , Juntendo University School of Medicine , Tokyo , Japan.
    We previously reported that autoantibodies against the proliferating cell nuclear antigen protein (PCNA)-binding protein chromatin assembly factor-1 (CAF-1) are specifically found in patients with systemic lupus erythematosus (SLE). PCNA and its complex constituents elicit autoimmune responses in patients with SLE, suggesting that autoantibody diversification likely occurs owing to epitope spreading. Therefore, we sought to clarify whether patients with SLE exhibit an autoimmune response to Ribonuclease H2 (RNase H2), another PCNA-binding protein that regulates cell division. Read More

    Common variants near IKZF1 are associated with primary Sjögren's syndrome in Han Chinese.
    PLoS One 2017 26;12(5):e0177320. Epub 2017 May 26.
    CAS Key Laboratory of Mental Health, Institute of Psychology, Beijing, China.
    Primary Sjögren's syndrome (pSS) is a systematic autoimmune disease with evidence of genetic predisposition. The IKZF1 (IKAROS family zinc finger 1 (Ikaros)) gene is located at 7p12.2, encodes a transcription factor related to chromatin remodeling, regulates lymphocyte differentiation, and has been reported to be associated with some autoimmune diseases. Read More

    [Severe Interstitial Lung Disease and Manic Symptoms Secondary to Corticosteroids in a Patient with Systemic Lupus Erythematosus and Secondary Sjögren's Syndrome].
    Acta Med Port 2017 Mar 31;30(3):246-250. Epub 2017 Mar 31.
    Serviço de Reumatologia. Hospital de Egas Moniz. Centro Hospitalar de Lisboa Ocidental. Lisboa. Portugal. CEDOC. NOVA Medical School/Faculdade de Ciências Médicas. Universidade NOVA de Lisboa. Lisboa. Portugal.
    Interstitial lung disease occurs in up to 25% of patients with Sjögren's syndrome and 2% - 8 % of patients with systemic lupus erythematosus. Corticosteroid therapy remains the main treatment for systemic lupus erythematosus. However, it can be associated with several neuropsychiatric disorders especially with prednisolone at a dose of more than 40 mg/day. Read More

    Degradation of proteoglycan 4/lubricin by cathepsin S: Potential mechanism for diminished ocular surface lubrication in Sjögren's syndrome.
    Exp Eye Res 2017 May 23;161:1-9. Epub 2017 May 23.
    Faculty of Kinesiology, University of Calgary, Calgary, AB, Canada; Biomedical Engineering Graduate Program, University of Calgary, Calgary, AB, Canada. Electronic address:
    Sjögren's syndrome (SS) is an autoimmune disease affecting the lacrimal and salivary glands with hallmark clinical symptoms of dry eye and dry mouth. Recently, markedly increased cathepsin S (CTSS) activity has been observed in the tears of SS patients. Proteoglycan 4 (PRG4), also known as lubricin, is an effective boundary lubricant that is naturally present on the ocular surface. Read More

    Comparison of corneal biomechanics in Sjögren's syndrome and non-Sjögren's syndrome dry eyes by Scheimpflug based device.
    Int J Ophthalmol 2017 18;10(5):711-716. Epub 2017 May 18.
    Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.
    Aim: To compare the corneal biomechanics of Sjögren's syndrome (SS) and non-SS dry eyes with Corneal Visualization Scheimpflug Technology (CorVis ST).

    Methods: Corneal biomechanics and tear film parameters, namely the Schirmer I test value, tear film break-up time (TBUT) and corneal staining score (CSS) were detected in 34 eyes of 34 dry eye patients with SS (SSDE group) and 34 dry eye subjects without SS (NSSDE group) using CorVis ST. The differences of the above parameters between the two groups were examined, and the relationship between corneal biomechanics and tear film parameters were observed. Read More

    Haematological Malignancies in Systemic Sclerosis Patients: Case Reports and Review of the World Literature.
    Case Rep Rheumatol 2017 4;2017:6230138. Epub 2017 May 4.
    Rheumatology Unit, Azienda Ospedaliero-Universitaria Policlinico di Modena, University of Modena and Reggio Emilia, Modena, Italy.
    Background. The association of systemic sclerosis (SSc) and haematological cancers was reported in a large number of case reports and cohort studies, describing SSc patients with highly heterogeneous clinical pictures. Objective. Read More

    Sjögren's syndrome is associated with negatively variable impacts on domains of health-related quality of life: evidence from Short Form 36 questionnaire and a meta-analysis.
    Patient Prefer Adherence 2017 10;11:905-911. Epub 2017 May 10.
    Department of Nursing, The Second Affiliated Hospital of Nantong University.
    Purpose: The purpose of this article was to systematically review the literature to identify the impact of primary Sjögren's syndrome (pSS) on specific health-related quality of life (HRQoL) domains.

    Methods: A meta-analysis was performed, and the related articles were searched in Medline, Embase, Cochrane Library, China National Knowledge Infrastructure, China Biology Medicine, and Web of Science databases and in reference lists of articles and systematic reviews. Score of the Short Form 36 (SF-36) questionnaire was used as the outcome measurement, and mean differences (MD) with 95% confidence intervals (CIs) were calculated. Read More

    Clinical, Biochemical, and Genetic Aspects of Sjögren-Larsson Syndrome.
    Clin Genet 2017 May 23. Epub 2017 May 23.
    Department of Rehabilitation medicine, CHA Bundang Medical Center, CHA University.
    Sjögren-Larsson syndrome (SLS) is caused by an autosomal recessive mutation in ALDH3A2, which encodes the fatty aldehyde dehydrogenase responsible for the metabolism of long-chain aliphatic aldehydes and alcohols. The pathophysiologic accumulation of aldehydes in various organs, including the skin, brain, and eyes, leads to characteristic features of ichthyosis, intellectual disability, spastic di-/quadriplegia, and low visual acuity with photophobia. The severity of the clinical manifestations thereof can vary greatly, although most patients are bound to a wheelchair due to contractures. Read More

    Signification of distal urinary acidification defects in hypocitraturic patients.
    PLoS One 2017 19;12(5):e0177329. Epub 2017 May 19.
    Université Paris Descartes, Faculté de Médecine, Paris, France.
    Background And Objectives: Hypocitraturia has been associated with metabolic acidosis and mineral disorders. The aim of this study was to investigate the occurrence of urinary acidification defects underlying hypocitraturia.

    Materials And Methods: This retrospective observational study included 67 patients (32 men), aged 40. Read More

    Immediate Loading of Tantalum-Based Implants in Fresh Extraction Sockets in Patient With Sjogren Syndrome: A Case Report and Literature Review.
    Implant Dent 2017 May 22. Epub 2017 May 22.
    *Private Practice in Implant Dentistry and Periodontology, Turin, Italy.†Research Associate and Resident, Department of General Dentistry, Eastman Institute for Oral Health, University of Rochester, Rochester, NY.‡Professor, Department of Periodontology, Stony Brook University, School of Dental Medicine, Stony Brook, NY; Department of Oral Surgery and Implant Dentistry, Dental School, Johann Wolfgang Goethe University Frankfurt, Frankfurt, Germany.
    Purpose: The objective of this article is to demonstrate treatment of a clinical case using implants in conjunction with immediate loading in a patient with Sjogren syndrome (SS) and to present the current status of knowledge about this type of patients with dental implants.

    Materials And Methods: This article describes a 62-year-old woman patient with SS and partially edentulous maxilla who was rehabilitated with 5 immediately loaded tantalum-based dental implants (TBDIs) placed in fresh extraction sockets. Six nonrestorable teeth were atraumatically extracted and immediate TBDI were placed in the fresh extraction sites. Read More

    Scleral Contact Lenses in an Academic Oculoplastics Clinic: Epidemiology and Emerging Considerations.
    Ophthal Plast Reconstr Surg 2017 May 22. Epub 2017 May 22.
    *Department of Ophthalmology and Visual Sciences, Carver College of Medicine, University of Iowa Hospitals and Clinic, Iowa City, Iowa, †Carver College of Medicine, University of Iowa, Iowa City, Iowa, ‡Department of Ophthalmology, Cincinnati Eye Institute, Cincinnati, Ohio, and §Department of Otolaryngology- Head and Neck Surgery, Carver College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, Iowa, U.S.A.
    Purpose: To describe the role and efficacy of scleral contact lenses (SCLs) in the treatment of progressive keratopathy in patients who have undergone periocular surgical procedures, to investigate the financial impact of these surgical interventions, and to demonstrate the role of oculoplastic surgery in improving scleral contact lens fit.

    Methods: A retrospective medical record review was performed to identify patients who both received SCLs and were examined by the oculoplastics service at the University of Iowa between January 1990 and December 2015. Inclusion criteria also required a minimum of 12 months of patient follow up after being fit with a SCL. Read More

    Characteristics of labial gland Mesenchymal Stem Cells of healthy individuals and patients with Sjögren syndrome: a preliminary study.
    Stem Cells Dev 2017 May 24. Epub 2017 May 24.
    Peking University School of Stomatology, 159460, Beijing, Beijing, China ;
    Sjögren's Syndrome (SS) is a systemic autoimmune disease characterized by focal lymphocytic infiltration into exocrine organs such as salivary and lacrimal glands, resulting in dry mouth and eyes, and other systemic injuries. The mesenchymal stem cells (MSCs) in the salivary glands of healthy individuals and patients with SS have not been extensively studied. The aim of this study was to eluciadate the characteristics of MSCs from the labial glands of healthy controls and of those from patients with SS in order to elucidate the related pathogenesis and uncover potential avenues for novel clinical interventions. Read More

    Are the women with Sjögren's Syndrome satisfied with their sexual activity?
    Rev Bras Reumatol Engl Ed 2017 May - Jun;57(3):210-216. Epub 2017 Feb 8.
    Bulent Ecevit University, School of Medicine, Department of Family Medicine, Zonguldak, Turkey.
    Objective: Females with Sjögren's Syndrome (SS) often experience vaginal dryness and dyspareunia, along with glandular and extraglandular symptoms. We aimed to evaluate sexual function and life quality in women with SS.

    Methods: Forty-six premenopausal women with SS and 47 age-matched controls were studied. Read More

    Research and progress on ClC‑2 (Review).
    Mol Med Rep 2017 Jul 18;16(1):11-22. Epub 2017 May 18.
    Library, Qiqihar Medical University, Qiqihar, Heilongjiang 161006, P.R. China.
    Chloride channel 2 (ClC-2) is one of the nine mammalian members of the ClC family. The present review discusses the molecular properties of ClC‑2, including CLCN2, ClC‑2 promoter and the structural properties of ClC‑2 protein; physiological properties; functional properties, including the regulation of cell volume. The effects of ClC‑2 on the digestive, respiratory, circulatory, nervous and optical systems are also discussed, in addition to the mechanisms involved in the regulation of ClC‑2. Read More

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