Unique glandular ex-vivo Th1 and Th17 receptor motifs in Sjögren's syndrome patients using single-cell analysis.
- Alexandria Voigt,
- Katherine Bohn,
- Sukesh Sukumaran,
- Carol M Stewart,
- Indraneel Bhattacharya,
- Cuong Q Nguyen
Clin Immunol 2018 Apr 18. Epub 2018 Apr 18.
Department of Infectious Diseases and Pathology, College of Veterinary Medicine, University of Florida, Gainesville, Florida, USA; Department of Oral Biology, USA; Center of Orphaned Autoimmune Diseases, University of Florida, Gainesville, Florida, USA. Electronic address:
Primary Sjögren's syndrome (pSS) is an autoimmune disease in which the underlying cause has yet to be elucidated. The main objective of this study was to determine the T cell receptor (TCR) repertoires of individual infiltrating T helper (Th)-1 and 17 cells of pSS patients using single-cell analysis. Single-cell analysis of ex-vivo infiltrating T cells demonstrated that pSS patients had higher frequencies of activated Th17 cells. Read More