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    Research and progress on ClC‑2 (Review).
    Mol Med Rep 2017 May 18. Epub 2017 May 18.
    Library, Qiqihar Medical University, Qiqihar, Heilongjiang 161006, P.R. China.
    Chloride channel 2 (ClC-2) is one of the nine mammalian members of the ClC family. The present review discusses the molecular properties of ClC‑2, including CLCN2, ClC‑2 promoter and the structural properties of ClC‑2 protein; physiological properties; functional properties, including the regulation of cell volume. The effects of ClC‑2 on the digestive, respiratory, circulatory, nervous and optical systems are also discussed, in addition to the mechanisms involved in the regulation of ClC‑2. Read More

    Surgical Aortic Valve Replacement Following Early Sapien-XT Valve Failure: A First.
    Heart Lung Circ 2017 May 9. Epub 2017 May 9.
    Department of Cardiothoracic Surgery, Royal Melbourne Hospital, Melbourne, Vic, Australia.
    Background: Early degeneration of prosthetic aortic valve in transcatheter aortic valve replacement (TAVR) is a rare complication.

    Method: We report the case of a 75-year-old woman who presented with severe calcific stenosis of Edwards SAPIEN-XT valve implanted only four years previously. She is a Jehovah's Witness and has background of Sjogren's syndrome with secondary cryoglobulinaemic vasculitis. Read More

    Updates on Sjögren's syndrome: from proteomics to protein biomarkers.
    Expert Rev Proteomics 2017 May 23. Epub 2017 May 23.
    a Department of Clinical and Experimental Medicine , University of Pisa , via Roma 67, 56100 Pisa , Italy.
    Introduction: Primary Sjögren's syndrome (pSS) is a complex heterogeneous autoimmune disorder, typically affecting exocrine glands. Recently, a great interest has arisen in searching for novel biomarkers able to improve the diagnostic work-up of the disease as well as the general assessment and the prognostic stratification of pSS patients. From this perspective, salivary proteomics has appeared as a promising tool considering that salivary proteins may closely reflect the underlying disease processes in the salivary glands. Read More

    Fetal and neonatal involvement in maternal rheumatologic disease.
    J Matern Fetal Neonatal Med 2017 May 22:1-22. Epub 2017 May 22.
    a Department of Pediatrics , Hamamatsu University School of Medicine , Shizuoka , Japan.
    A pregnancy complicated with rheumatologic diseases can have various influences on the fetus and/or neonate. Maternal systemic lupus erythematosus (SLE) may cause preterm and/or small for gestational age (SGA) delivery and neonatal lupus (NL). Some neonates with NL have congenital heart block (CHB) with increased morbidity and mortality, even requiring pacemakers. Read More

    Myeloid Populations in Systemic Autoimmune Diseases.
    Clin Rev Allergy Immunol 2017 May 20. Epub 2017 May 20.
    Genomic Medicine Department, GENYO, Centre for Genomics and Oncological Research: Pfizer / University of Granada / Andalusian Regional Government, PTS Granada, Avda de la Ilustración 114, 18016, Granada, Spain.
    Systemic autoimmune diseases (SADs) encompass a wide spectrum of clinical signs as a reflection of their complex physiopathology. A variety of mechanisms related with the innate immune system are in the origin of the loss of self-tolerance in these diseases, and for most of them, the myeloid leukocytes are key actors. Monocytes, macrophages, dendritic cells, and neutrophils are first-line immune effectors located in the interface between innate and adaptive immunity. Read More

    Correlation between corneal innervation and inflammation evaluated with confocal microscopy and symptomatology in patients with dry eye syndromes: a preliminary study.
    Graefes Arch Clin Exp Ophthalmol 2017 May 20. Epub 2017 May 20.
    Doheny Image Reading Center, Doheny Eye Institute, 1355 San Pablo Street, DVRC 211, Los Angeles, CA, 90033, USA.
    Purpose: To evaluate corneal innervation and inflammatory cell infiltration using in vivo confocal microscopy (IVCM) and to correlate these findings with subjective symptoms of dry eye, as measured by the Ocular Surface Disease Index (OSDI) in patients with non-Sjögren's (NSDE) and Sjögren's syndrome dry eyes (SSDE).

    Methods: Central corneal images were prospectively captured from 10 age-matched healthy control eyes, 24 eyes with clinically diagnosed NSDE and 44 eyes with clinically diagnosed SSDE, using IVCM (HRT III RCM). Density, tortuosity and reflectivity of corneal nerves, presence of inflammatory dendritic cells (DCs) and OSDI scores were evaluated. Read More

    Comparison of the diagnostic value of four scoring systems in primary sjögren's syndrome patients.
    Immunol Lett 2017 May 17. Epub 2017 May 17.
    Department of Rheumatism and immunology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, China. Electronic address:
    Purpose: We attempted to evaluate the diagnostic value of different salivary gland ultrasonography (SGUS) scoring systems for primary sjögren's syndrome (pSS).

    Methods: Total 134 patients with pSS and 109 non-SS sicca controls were included in our study. All the cases were evaluated by four scoring systems (such as 0-16 SGUS, 0-3 SGUS, Parotid glands and Submandibular salivary glands scoring system). Read More

    Systemic manifestations of primary Sjögren's syndrome in the NOD.B10Sn-H2(b)/J mouse model.
    Clin Immunol 2017 May 16. Epub 2017 May 16.
    Department of Oral Biology and Department of Oral Diagnostics Sciences, School of Dental Medicine, University of Buffalo, The State University of New York, Buffalo, NY 14214, USA; Autoimmune Division, Trinity Biotech, 60 Pineview Drive, Buffalo, NY 14228, USA; Department of Oral Diagnostics Sciences, School of Dental Medicine, University of Buffalo, The State University of New York, Buffalo, NY 14214, USA. Electronic address:
    Animal models that recapitulate human disease are crucial for the study of Sjögren's Syndrome (SS). While several SS mouse models exist, there are few primary SS (pSS) models that mimic systemic disease manifestations seen in humans. Similar to pSS patients, NOD. Read More

    Coexistence of ulcerative colitis and Sjögren's syndrome in a patient with Takayasu's arteritis and Hashimoto's thyroiditis.
    Intest Res 2017 Apr 27;15(2):255-259. Epub 2017 Apr 27.
    Department of Pathology, Kyungpook National University School of Medicine, Daegu, Korea.
    A 31-year-old woman with a 15-year history of Takayasu's arteritis (TA) and a 13-year history of Hashimoto's thyroiditis presented with hematochezia. She received a diagnosis of Sjögren's syndrome at 1 month before her visit to Kyungpook National University Medical Center. Her colonoscopic findings were compatible with a diagnosis of ulcerative colitis (UC). Read More

    Multiomic disease signatures converge to cytotoxic CD8 T cells in primary Sjögren's syndrome.
    Ann Rheum Dis 2017 May 18. Epub 2017 May 18.
    Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.
    Objectives: Multiomics study was conducted to elucidate the crucial molecular mechanisms of primary Sjögren's syndrome (SS) pathology.

    Methods: We generated multiple data set from well-defined patients with SS, which includes whole-blood transcriptomes, serum proteomes and peripheral immunophenotyping. Based on our newly generated data, we performed an extensive bioinformatic investigation. Read More

    Sialendoscopic management of autoimmune sialadenitis: a review of literature.
    Acta Otorhinolaryngol Ital 2017 Apr;37(2):148-154
    Department of Sensorial Organs, ENT Section "Sapienza" University of Rome, Italy.
    Autoimmune diseases of major salivary glands include Sjögren's syndrome and a complex of disorders classified as immunoglobulin G4-related diseases. These pathologies are characterised by an autoimmune reaction mediated by T-helper lymphocytes that targets the ducts of exocrine glands in Sjögren's syndrome and glandular parenchyma in immunoglobulin G4-related diseases. Immunoglobulin G4-related diseases represent recently introduced multi-organ diseases that also involve the salivary glands. Read More

    Salivary biomarkers and proteomics: future diagnostic and clinical utilities.
    Acta Otorhinolaryngol Ital 2017 Apr;37(2):94-101
    Department of Head and Neck Surgery, "A. Gemelli" Hospital Foundation, Catholic University, Rome, Italy.
    Saliva testing is a non-invasive and inexpensive test that can serve as a source of information useful for diagnosis of disease. As we enter the era of genomic technologies and -omic research, collection of saliva has increased. Recent proteomic platforms have analysed the human salivary proteome and characterised about 3000 differentially expressed proteins and peptides: in saliva, more than 90% of proteins in weight are derived from the secretion of three couples of "major" glands; all the other components are derived from minor glands, gingival crevicular fluid, mucosal exudates and oral microflora. Read More

    RAPID3 correlates with ESSPRI and other patient-reported outcomes in patients with primary Sjögren's syndrome.
    Clin Exp Rheumatol 2017 May 15. Epub 2017 May 15.
    Department of Internal Medicine, Centre for Rheumatic Diseases, Tampere University Hospital, Tampere, Finland and University of Tampere, Faculty of Medicine and Life Sciences, Tampere, Finland.
    ****************************************************************************. Read More

    Secondary Sjogren's Syndrome Presenting with Distal Tubular Acidosis and Quadriparesis.
    Indian J Crit Care Med 2017 Apr;21(4):243-244
    Department of Critical Care Medicine, Yashoda Multi-speciality Hospital, Hyderabad, Telangana, India.
    A 52-year-old female patient was admitted to Intensive Care Unit with complaints of quadriparesis. Investigations revealed distal renal tubular acidosis (DRTA) secondary to Sjogren's syndrome with involvement of the parotid and thyroid glands. Laboratory investigations showed hyperchloremic metabolic acidosis and an alkaline urine pH with clinical signs of sicca syndrome. Read More

    Malignancy as a comorbidity in rheumatic diseases: a retrospective hospital-based study.
    Clin Rheumatol 2017 May 16. Epub 2017 May 16.
    Division of Oncology, Guang An Men Hospital affiliated to China Academy of Traditional Chinese Medicine, Beijing, 100053, China.
    Patients with Rheumatic diseases (RDs) are at an increased risk of malignancies compared with the general population. The aim of this study was to examine the relative frequency of several cancers in a single homogeneous cohort of patients with different RDs. Patients diagnosed with rheumatoid arthritis (RA), Ankylosing spondylitis (AS), Sjögren's syndrome (SS), systemic lupus erythematosus (SLE), systemic sclerosis (SSc), dermatomyositis (DM), or polymyositis were included. Read More

    Difference in clinical presentation between women and men in incident primary Sjögren's syndrome.
    Biol Sex Differ 2017 12;8:16. Epub 2017 May 12.
    Unit of Experimental Rheumatology, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, SE-171 76 Stockholm, Sweden.
    Background: A more severe disease phenotype has been reported in men compared to women in several rheumatic diseases. However, studies have not conclusively established sex-related clinical features in primary Sjögren's syndrome (pSS). In this study, we therefore investigated the clinical presentation of pSS in women and men at diagnosis. Read More

    Cryoglobulinemia in Sjögren Syndrome: A Disease Subset that Links Higher Systemic Disease Activity, Autoimmunity, and Local B Cell Proliferation in Mucosa-associated Lymphoid Tissue.
    J Rheumatol 2017 May 15. Epub 2017 May 15.
    From the Rheumatology Clinic, Department of Medical and Biological Sciences, Azienda Ospedaliero-Universitaria S. Maria della Misericordia, Udine; Rheumatology Unit, Department of Internal Medicine, University of Pisa, Pisa; Rheumatology Unit, Sapienza University of Rome, Rome; Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Perugia, Perugia; Rheumatology Unit, University of L'Aquila, L'Aquila, Italy. L. Quartuccio, MD, PhD, Rheumatology Clinic, Department of Medical and Biological Sciences, Azienda Ospedaliero-Universitaria S. Maria della Misericordia; C. Baldini, MD, Rheumatology Unit, Department of Internal Medicine, University of Pisa; R. Priori, MD, Rheumatology Unit, Sapienza University of Rome; E. Bartoloni, MD, Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Perugia; F. Carubbi, MD, Rheumatology Unit, University of L'Aquila; A. Alunno, MD, Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Perugia; S. Gandolfo, MD, Rheumatology Clinic, Department of Medical and Biological Sciences, Azienda Ospedaliero-Universitaria S. Maria della Misericordia; S. Colafrancesco, MD, Rheumatology Unit, Sapienza University of Rome; R. Giacomelli, MD, Professor, Rheumatology Unit, University of L'Aquila; R. Gerli, MD, Professor, Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Perugia; G. Valesini, MD, Professor, Rheumatology Unit, Sapienza University of Rome; S. Bombardieri, MD, Professor, Rheumatology Unit, Department of Internal Medicine, University of Pisa; S. De Vita, MD, Professor, Rheumatology Clinic, Department of Medical and Biological Sciences, Azienda Ospedaliero-Universitaria S. Maria della Misericordia. Address correspondence to Dr. L. Quartuccio, Rheumatology Clinic, Department of Medical and Biological Sciences, Azienda Ospedaliero-Universitaria S. Maria della Misericordia, Udine, Italy. E-mail: Accepted for publication April 4, 2017.
    Objective: To compare systemic disease activity by validated tools, i.e., the European League Against Rheumatism Sjögren Syndrome Disease Activity Index (ESSDAI) and the Clinical ESSDAI (ClinESSDAI) scores, between primary Sjögren syndrome (pSS) with positive serum cryoglobulins and pSS without serum cryoglobulins. Read More

    The P2X7 receptor-NLRP3 inflammasome complex predicts the development of non-Hodgkin's lymphoma in Sjogren's syndrome: a prospective, observational, single-center study.
    J Intern Med 2017 May 15. Epub 2017 May 15.
    Department of Surgical, Medical, Molecular and Critical Area Pathology University of Pisa, Italy.
    Background: P2X7 receptor (P2X7R), trigger of acute inflammatory responses via the NLRP3 inflammasome, is hyperfunctioning in patients with Sjogren Syndrome (SS), where it stimulates IL-18 production. Some patients with SS develop a mucosa-associated lymphoid tissue non-Hodgkin's lymphoma (MALT-NHL).

    Objectives: To prospectively evaluate the involvement and the putative prognostic role of this inflammatory pathway in the development of MALT-NHL. Read More

    Associations between maternal risk factors of adverse pregnancy and birth outcomes and the offspring epigenetic clock of gestational age at birth.
    Clin Epigenetics 2017 8;9:49. Epub 2017 May 8.
    Institute of Behavioral Sciences, University of Helsinki, Helsinki, 00014 Finland.
    Background: A recent study has shown that it is possible to accurately estimate gestational age (GA) at birth from the DNA methylation (DNAm) of fetal umbilical cord blood/newborn blood spots. This DNAm GA predictor may provide additional information relevant to developmental stage. In 814 mother-neonate pairs, we evaluated the associations between DNAm GA and a number of maternal and offspring characteristics. Read More

    Differentiating (131)I Radiation Sialadenitis From Autoimmune (Sjögren Syndrome) Sialadenitis: Case Report.
    J Oral Maxillofac Surg 2017 Apr 17. Epub 2017 Apr 17.
    Clinical Professor, Department of Medicine (Endocrinology), New York University School of Medicine, New York, NY.
    Radioactive iodine ((131)I) is used effectively for the treatment of differentiated thyroid cancers. Because it is actively secreted by the salivary glands, radiation damage to these glands can occur. Obstructive swellings after mealtime salivary stimulation are common occurrences. Read More

    Is hydroxychloroquine effective in treating primary Sjogren's syndrome: a systematic review and meta-analysis.
    BMC Musculoskelet Disord 2017 May 12;18(1):186. Epub 2017 May 12.
    Department of Oral Medicine, Peking University School and Hospital of Stomatology & National Engineering Laboratory for Digital and Material Technology of Stomatology, 22 South Zhongguancun Avenue, Haidian District, Beijing, 100081, China.
    Background: To systematically review and assess the efficacy and safety of hydroxychloroquine (HCQ) for treating primary Sjogren's syndrome (pSS).

    Methods: Five electronic databases (Pubmed, EMBASE, Web of science, Ovid, Cochrane Library) were searched for randomized controlled trials and retrospective or prospective studies published in English that reported the effect of HCQ on pSS. The subjective symptoms (sicca symptoms, fatigue and pain) and the objective indexes (erythrocyte sedimentation rate and Schirmer test) were assessed as main outcome measures. Read More

    MALT Lymphoma of Minor Salivary Glands in a Sjögren's Syndrome Patient: a Case Report and Review of Literature.
    J Oral Maxillofac Res 2017 Jan-Mar;8(1):e5. Epub 2017 Mar 31.
    Department of Oral Medicine and Pathology, School of Dentistry, National and Kapodistrian University of Athens, AthensGreece.
    Background: Sjögren's syndrome is a chronic systemic disease, characterized by lymphocytic infiltration and destruction mainly of the salivary and lacrimal glands, resulting in xerostomia and xeropthalmia. Sjögren's syndrome patients have a 44-fold excess risk for the development of non-Hodgkin's lymphoma particularly mucosa-associated lymphoid tissue (MALT) lymphoma, prevalently affecting the major salivary glands. In this report, a rare case of MALT lymphoma of minor salivary glands in a patient with Sjögren's syndrome is described. Read More

    Functional Analysis of Dendritic Cells Generated from T-iPSCs from CD4+ T Cell Clones of Sjögren's Syndrome.
    Stem Cell Reports 2017 May;8(5):1155-1163
    Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba 305-8575, Japan. Electronic address:
    Although it is important to clarify the pathogenic functions of T cells in human samples, their examination is often limited due to difficulty in obtaining sufficient numbers of dendritic cells (DCs), used as antigen-presenting cells, especially in autoimmune diseases. We describe the generation of DCs from induced pluripotent stem cells derived from T cells (T-iPSCs). We reprogrammed CD4+ T cell clones from a patient with Sjögren's syndrome (SS) into iPSCs, which were differentiated into DCs (T-iPS-DCs). Read More

    Sonographic findings of IgG4-related disease of the salivary glands: Case report and review of the literature.
    J Clin Ultrasound 2017 May 11. Epub 2017 May 11.
    Department of Radiology, Johns Hopkins Bayview Medical Center, 4940 Eastern Avenue, Baltimore, MD, 21224.
    IgG4-related disease is a relatively newly described entity with findings that historically have been confused with a variety of other diseases with markedly different treatments and prognoses, including Sjogren's syndrome and MALT lymphoma. We present a case of IgG4-related disease of the salivary glands and review the literature on sonographic findings of IgG4-related disease. By connecting sonographic features of IgG4 disease with common ancillary features of IgG4 disease in other sites (pancreas, hilar lymph nodes, biliary tree, thyroid, and retroperitoneum), radiologists can play a pivotal role in the early diagnosis and identification of IgG4-related disease. Read More

    Pulmonary MALT Lymphoma in Patients with Sjogren's Syndrome.
    Clin Med Res 2017 May 9. Epub 2017 May 9.
    Department of Pulmonary Medicine, Marshfield Clinic, Marshfield, Wisconsin USA.
    To describe clinical features and outcomes of seven patients with pulmonary mucosa-associated lymphoid tissue (MALT) lymphoma in the setting of underlying primary Sjogren's syndrome from a single center, we reviewed medical records of consecutive patients with pulmonary MALT lymphoma evaluated at our facility from January 1, 1999 to December 31, 2015 for clinical features, laboratory, pathologic and radiographic findings, management, and outcomes. Out of 13 patients with pulmonary MALT lymphoma, 7 (54 %) met the criteria for Sjogren's syndrome. The mean age at lymphoma diagnosis was 66 years; male-female ratio was 1:6. Read More

    Association between a history of mycobacterial infection and the risk of newly diagnosed Sjögren's syndrome: A nationwide, population-based case-control study.
    PLoS One 2017 9;12(5):e0176549. Epub 2017 May 9.
    Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan.
    Objective: To address the association between a history of tuberculosis (TB) or nontuberculous mycobacterial (NTM) infection and the risk of newly diagnosed Sjögren's syndrome (SS).

    Methods: Using a nationwide, population-based, claims dataset, and after excluding those who had rheumatoid arthritis or systemic lupus erythematosus, we identified 5,751 newly diagnosed SS cases during 2007-2012, and compared them to 86,265 non-SS controls matched (1:15) for age, sex, and the year of first SS diagnosis date. The association between the risk of incident SS and a history of mycobacterial infection, including TB and NTM, was quantified by calculating odds ratios (ORs) with 95% confidence intervals (CIs) using conditional logistic regression analysis after adjustment for Charlson comorbidity index (CCI) and bronchiectasis. Read More

    Comparison of Tear Osmolarity in Rheumatoid Arthritis Patients With and Without Secondary Sjogren Syndrome.
    Cornea 2017 May 8. Epub 2017 May 8.
    *Department of Ophthalmology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China; †Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China; and ‡Department of Biomedical Sciences, The City University of Hong Kong, Hong Kong SAR, China.
    Purpose: To compare tear osmolarity (TO) and other dry eye parameters in rheumatoid arthritis (RA) patients with or without secondary Sjogren syndrome (sSS).

    Methods: Consecutive patients with RA were divided into a sSS group and no-sSS group using conventional diagnostic criteria by rheumatologists using symptomatology, Schirmer test score, and anti-Ro or anti-La autoantibody status. The TO, Ocular Surface Disease Index, dry eye disease (DED) parameters [such as tear breakup time (TBUT) and corneal staining score] and the systemic inflammatory markers [erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP)] were compared. Read More

    HIF1A (rs11549465) and AKNA (rs10817595) Gene Polymorphisms Are Associated with Primary Sjögren's Syndrome.
    Biomed Res Int 2017 6;2017:5845849. Epub 2017 Apr 6.
    Synovial Fluid Laboratory, Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, Mexico City, Mexico.
    Objective. To evaluate the allele and genotype frequencies of polymorphic sites of HIF1A and ANKA genes in primary Sjögren's syndrome (pSS). Methods. Read More

    Activation of MMP-9 activity by acrolein in saliva from patients with primary Sjögren's syndrome and its mechanism.
    Int J Biochem Cell Biol 2017 May 5;88:84-91. Epub 2017 May 5.
    Amine Pharma Research Institute,Innovation Plaza at Chiba University, 1-8-15 Inohana, Chuo-ku, Chiba, Chiba 260-0856, Japan; Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, Chiba 260-8675, Japan. Electronic address:
    We have recently reported that the altered recognition patterns of immunoglobulins due to acrolein conjugation are at least partially responsible for autoimmune diseases in patients with primary Sjögren's syndrome (pSS). In the current study, it was found that the specific activity (activity/ng protein) of metalloproteinase-9 (MMP-9) in saliva was elevated about 2.4-fold in pSS patients. Read More

    MicroRNAs in ocular surface and dry eye diseases: Good, bad and healing situations.
    Ocul Surf 2017 May 5. Epub 2017 May 5.
    Department of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil. Electronic address:
    Since the first description of microRNAs (miRNAs) in the nineties of last century, more than 60 papers have described the role of miRNAs on the ocular surface and lacrimal gland. MicroRNAs (miRNAs) have been implicated in several physiological events and also as mediators of diseases. They inhibit the gene expression by blocking the messenger RNA. Read More

    Complications of Sialendoscopy in Patients With Sjögren Syndrome.
    J Oral Maxillofac Surg 2017 May 6;75(5):978-983. Epub 2016 Oct 6.
    Assistant Professor, Department of Oral and Maxillofacial Surgery and Oral Pathology, VU University Medical Center; Center for Special Care Dentistry (SBT), Amsterdam, The Netherlands.
    Purpose: Recent literature suggests that sialendoscopy of the major salivary glands could alleviate symptoms of Sjögren syndrome (SS) and restore salivary function. The aim of this study was to evaluate the authors' experience of sialendoscopy of the salivary glands in patients with SS.

    Materials And Methods: In this retrospective case series study, the surgical data of patients with SS who had undergone sialendoscopy at the VU University Medical Center (Amsterdam, The Netherlands) from November 2014 through April 2015 were used. Read More

    Coffee and autoimmunity: More than a mere hot beverage!
    Autoimmun Rev 2017 May 4. Epub 2017 May 4.
    Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel; Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel. Electronic address:
    Coffee is one of the world's most consumed beverage. In the last decades, coffee consumption has attracted a huge body of research due to its impact on health. Recent scientific evidences showed that coffee intake could be associated with decreased mortality from cardiovascular and neurological diseases, diabetes type II, as well as from endometrial and liver cancer, among others. Read More

    The psychometric properties of the Evaluation of Daily Activity Questionnaire in seven musculoskeletal conditions.
    Disabil Rehabil 2017 May 8:1-11. Epub 2017 May 8.
    d Division of Nursing, Midwifery & Social Work , University of Manchester , Manchester , UK.
    Purpose: The purpose of this study is to psychometrically test the Evaluation of Daily Activity Questionnaire in seven musculoskeletal conditions.

    Materials And Methods: One thousand and two hundred people with ankylosing spondylitis; osteoarthritis; systemic lupus erythematosus; systemic sclerosis; chronic pain; chronic upper limb disorders; or Primary Sjögren's syndrome completed the Evaluation of Daily Activity Questionnaire, Health Assessment Questionnaire and Short-Form Health Survey v2. We examined internal construct validity using Rasch analysis, internal consistency, concurrent validity with the Health Assessment Questionnaire and Short-Form Health Survey v2. Read More

    The value of rituximab treatment in primary Sjögren's syndrome.
    Clin Immunol 2017 May 3. Epub 2017 May 3.
    Departments of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
    The rationale for B-cell depletion therapy with rituximab in pSS relies upon the well-established role of B-cell hyperactivity in immunopathogenesis. In line with this notion, several biomarkers of B-cell activity are significantly affected by treatment, both in the target organs and periphery. In contrast to most biological outcomes, clinical outcomes are not consistent between studies. Read More

    What can Sjögren's syndrome-like disease in mice contribute to human Sjögren's syndrome?
    Clin Immunol 2017 May 3. Epub 2017 May 3.
    Department of Pathology and Infectious Diseases, College of Veterinary Medicine, University of Florida, Gainesville, FL 32608, USA; Center for Orphan Autoimmune Disorders, College of Dentistry, University of Florida, Gainesville, FL 32608, USA; Department of Oral Biology, College of Dentistry, University of Florida, FL 32608, USA.
    For decades, Sjögren's syndrome (SS) and Sjögren's syndrome-like (SS-like) disease in patients and mouse models, respectively, have been intensely investigated in attempts to identify the underlying etiologies, the pathophysiological changes defining disease phenotypes, the nature of the autoimmune responses, and the propensity for developing B cell lymphomas. An emerging question is whether the generation of a multitude of mouse models and the data obtained from their studies is actually important to the understanding of the human disease and potential interventional therapies. In this brief report, we comment on how and why mouse models can stimulate interest in specific lines of research that apparently parallel aspects of human SS. Read More

    Sjogren's syndrome from the perspective of ophthalmology.
    Clin Immunol 2017 May 2. Epub 2017 May 2.
    Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States; Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, NY, New York 10029, United States. Electronic address:
    Sjogren's syndrome (SS) is an autoimmune disease affecting the lacrimal glands resulting in dry eye disease (DED). Ophthalmologists may be the first line of detection of Sjogren's syndrome given the frequency of DED in SS and that dry eye is often the presenting symptom. Numerous symptom questionnaires and tests have been developed to help diagnose DED, but as of yet, there is no "gold standard. Read More

    Genetics of Sjögren's syndrome.
    Clin Immunol 2017 May 3. Epub 2017 May 3.
    Sjögren's Syndrome and Salivary Gland Dysfunction Unit, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA. Electronic address:
    The pathogenesis of Sjögren's syndrome has not been elucidated. There has been evidence that genetics play an important role in the development of this disease from earlier studies. However, till now only a number of genes have been identified to be associated with SS, and these have only a weak or moderate effect. Read More

    Could Lymphocyte Profiling be Useful to Diagnose Systemic Autoimmune Diseases?
    Clin Rev Allergy Immunol 2017 May 4. Epub 2017 May 4.
    Service de Rhumatologie, Hôpital de la Cavale Blanche, CHRU Brest, BP 824, 29609, Brest cedex, France.
    Considering the implications of B, T, and natural killer (NK) cells in the pathophysiology of systemic autoimmune diseases, the assessment of their distribution in the blood could be helpful for physicians in the complex process of determining a precise diagnosis. In primary Sjögren's syndrome, transitional and active naive B cells are increased and memory B cells are decreased compared to healthy controls and other systemic diseases. However, their utility to improve the accuracy of classification criteria has not been proven. Read More

    Down-regulation of increased TRAF6 expression in the peripheral mononuclear cells of patients with primary Sjögren's syndrome by an EBV-EBER1-specific synthetic single-stranded complementary DNA molecule.
    Int J Rheum Dis 2017 May 3. Epub 2017 May 3.
    Division of Clinical Immunology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
    Aim: We described earlier a simultaneously increased that the increased expression of miRNA-146a/b was accompanied by an increase in the expression of and TRAF6 and a decrease in the expression of IRAK1 genes in the peripheral mononuclear cells (PBMCs) of patients with primary Sjogren's syndrome (pSS) patients. Recently, the expression of EBV encoded. RNA (EBER) was published in the B cells of salivary glands of in pSS. Read More

    Oral manifestations of lupus.
    Ir J Med Sci 2017 May 3. Epub 2017 May 3.
    Department of Dermatology, St. James's Hospital, Dublin, 8, Ireland.
    Introduction: Mucosal involvement is commonly seen in patients with lupus; however, oral examination is often forgotten. Squamous cell carcinoma arising within oral lupoid plaques has been described, emphasizing the importance of identifying and treating oral lupus.

    Methods: We undertook a retrospective single-centre study looking at oral findings in patients attending our multidisciplinary lupus clinic between January 2015 and April 2016. Read More

    Sjogren's syndrome: Review of the aetiology, Pathophysiology & Potential therapeutic interventions.
    J Clin Exp Dent 2017 Apr 1;9(4):e584-e589. Epub 2017 Apr 1.
    College of Medicine and Dentistry, James Cook University, Townsville, Australia.
    Background: Sjogren's syndrome (SS) is an autoimmune disorder characterised by lymphocytic infiltration of exocrine glands, resulting in glandular dysfunction. Objectives: This study aims to review the aetiology of Sjogren's syndrome, highlight aspects that contribute to the pathophysiology of the disease and explore treatment options that target different mediators of pathogenesis.

    Material And Methods: The MEDLINE/PubMed and Google Scholar databases were searched systematically with the terms "Sjogren's syndrome"; "clinical"; "treatment"; "management". Read More

    HCV-unrelated cryoglobulinaemic vasculitis: the results of a prospective observational study by the Italian Group for the Study of Cryoglobulinaemias (GISC).
    Clin Exp Rheumatol 2017 Mar-Apr;35 Suppl 103(1):67-76. Epub 2017 Apr 19.
    Rheumatology Unit, Internal Medicine Unit, Presidio Ospedaliero di Saronno, ASST della Valle Olona, Italy.
    Objectives: To investigate the clinical and laboratory patterns of HCV-unrelated cryoglobulinaemic vasculitis (CV), and the factors influencing its outcome.

    Methods: Prospective study of all anti-HCV and HCV-RNA negative patients with CV who have been observed since January 2004 in 17 centres participating in the Italian Group for the Study of Cryoglobulinaemias (GISC).

    Results: 175 enrolled were followed up for 677 person-years. Read More

    CD8 T cells contribute to lacrimal gland pathology in the nonobese diabetic mouse model of Sjögren syndrome.
    Immunol Cell Biol 2017 May 3. Epub 2017 May 3.
    Stead Family Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
    Sjögren syndrome is an autoimmune disease characterized by targeted destruction of the lacrimal and salivary glands resulting in symptoms of severe ocular and oral dryness. Despite its prevalence, the mechanisms driving autoimmune manifestations are unclear. In patients and in the nonobese diabetic (NOD) mouse model of Sjögren syndrome, lymphocytic infiltrates consist of CD4 and CD8 T cells, although the role of CD8 T cells in disease pathogenesis has been largely unexplored. Read More

    Canadian Rheumatology Association Meeting, The Westin Ottawa, Ottawa, Ontario, Canada, February 8-11, 2017.
    J Rheumatol 2017 May 1. Epub 2017 May 1.
    The 72nd Annual Meeting of The Canadian Rheumatology Association (CRA) was held at The Westin Ottawa, Ottawa, Ontario, Canada, February 8-11, 2017. The program consisted of presentations covering original research, symposia, awards, and lectures. Highlights of the meeting include the following 2017 award winners: Dr. Read More

    [Coexistence of sarcoidosis and primary Sjögren syndrome: a clinical analysis and literature review].
    Zhonghua Nei Ke Za Zhi 2017 May;56(5):375-377
    Department of Pulmonary Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.
    Four patients with coexistence of sarcoidosis and primary Sjögren syndrome (pSS) were retrospectively analyzed.All patients were female, who were referred to our department mainly because of respiratory symptoms.Positive antinuclear antibody(ANA) was detected in 2 patients and anti-Sjögrens syndrome A (SSA) antibody positive in 1 patient. Read More

    Inhibition of lysophosphatidic acid receptor ameliorates Sjögren's syndrome in NOD mice.
    Oncotarget 2017 Apr;8(16):27240-27251
    Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon, Republic of Korea.
    Lysophosphatidic acid (LPA), a bioactive lysophospholipid, is involved in the pathogenesis of chronic inflammatory and autoimmune diseases. In this study, we investigated the role of LPA/LPA receptor (LPAR) signaling in the pathogenesis of Sjögren's syndrome (SS). We found that autotaxin, an LPA producing enzyme, and LPAR1 and LPAR3 mRNA, and IL-17 mRNA were highly expressed in the exocrine glands of 20-week-old nonobese diabetic (NOD) mice, which show SS symptoms at this age, as compared with non-symptomatic 8-week-old NOD mice. Read More

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