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    The role of biopsy in lacrimal gland inflammation: A clinicopathologic study.
    Orbit 2017 Aug 17:1-8. Epub 2017 Aug 17.
    e Department of Radiology , University of British Columbia and the Vancouver General Hospital , Vancouver , BC , Canada.
    Purpose: To determine the causes of lacrimal gland inflammation based on histopathology and systemic evaluation.

    Methods: This is a retrospective case series study. From the University of British Columbia Orbit Clinic between January 1976 and December 2008, we reviewed the medical records of 60 patients who presented with inflammatory features of the lacrimal gland (i. Read More

    Irgm1 coordinately regulates autoimmunity and host defense at select mucosal surfaces.
    JCI Insight 2017 Aug 17;2(16). Epub 2017 Aug 17.
    Immunity, Inflammation and Disease Laboratory and.
    The pathogenesis of primary Sjogren's syndrome (SS), an autoimmune disease that targets the mucosa of exocrine tissues, is poorly understood. Although several mouse models have been developed that display features of SS, most of these are within the larger context of a lupus-like presentation. Immunity-related GTPase family M protein 1 (Irgm1) is an interferon-inducible cytoplasmic GTPase that is reported to regulate autophagy and mitochondrial homeostasis. Read More

    The risk of autoimmune connective tissue diseases in patients with atopy: A nationwide population-based cohort study.
    Allergy Asthma Proc 2017 Sep;38(5):383-389
    Background: The relationship between autoimmune connective tissue disease (ACTD) and atopy is controversial.

    Objectives: To investigate the risks of ACTDs in patients with atopic triad diseases, including atopic dermatitis, allergic rhinitis, and asthma, by using a nationwide data base.

    Methods: A cohort of 155,311 patients newly diagnosed with atopic dermatitis, allergic rhinitis, or asthma in 2002-2011 was obtained from the Taiwan National Health Insurance Research Database. Read More

    The unmet need in rheumatology: Reports from the targeted therapies meeting 2017.
    Clin Immunol 2017 Aug 12. Epub 2017 Aug 12.
    University of California, Los Angeles Medical Center, Los Angeles, CA, USA.
    The 19th annual international Targeted Therapies meeting brought together over 100 leading basic scientists and clinical researchers from around the world in the field of immunology, molecular biology and rheumatology and other specialties. During the meeting, breakout sessions were held consisting of 5 disease-specific groups with 20-40 experts assigned to each group based on clinical or scientific expertise. Specific groups included: rheumatoid arthritis, psoriatic arthritis, axial spondyloarthritis, systemic lupus erythematous, connective tissue diseases (e. Read More

    NF-κB2 Controls Migratory Activity of Memory T Cells by Regulating Expression of CXCR4 in A Mouse Model of Sjögren's Syndrome.
    Arthritis Rheumatol 2017 Aug 13. Epub 2017 Aug 13.
    Department of Oral Molecular Pathology, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.
    Objective: Dysregulated chemokine signaling contributes to autoimmune diseases by facilitating aberrant T-cell infiltration into target tissues, but the specific chemokines, receptors, and T-cell populations remain largely unidentified. Role of the potent chemokine CXCL12 and its receptor CXCR4 in T-cell autoimmune response was examined using alymphoplasia (aly)/aly mice, a Sjögren's syndrome (SS) model.

    Methods: T-cell phenotypes in the salivary gland of aly/aly mice were evaluated using immunological analysis. Read More

    First Association of Interleukin 12 Receptor Beta 1 Deficiency with Sjögren's Syndrome.
    Front Immunol 2017 28;8:885. Epub 2017 Jul 28.
    Division of Immunology and Rheumatology, Hannover Medical University, Hanover, Germany.
    Introduction: Interleukin 12 receptor beta 1 (IL12Rβ1) deficiency is a primary immunodeficiency resulting mainly in susceptibility to opportunistic infection by non-tuberculous, environmental mycobacteria and severe infection caused by Salmonella spp. Till now, less than 300 patients with IL12Rβ1 deficiency have been reported. Among them, only three have been described to develop autoimmunity. Read More

    Human blood Tfr cells are indicators of ongoing humoral activity not fully licensed with suppressive function.
    Sci Immunol 2017 Aug;2(14)
    Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal.
    Germinal center (GC) responses are controlled by T follicular helper (Tfh) and T follicular regulatory (Tfr) cells and are crucial for the generation of high-affinity antibodies. Although the biology of human circulating and tissue Tfh cells has been established, the relationship between blood and tissue Tfr cells defined as CXCR5(+)Foxp3(+) T cells remains elusive. We found that blood Tfr cells are increased in Sjögren syndrome, an autoimmune disease with ongoing GC reactions, especially in patients with high autoantibody titers, as well as in healthy individuals upon influenza vaccination. Read More

    Primary Sjogren's syndrome and the risk of acute pancreatitis: a nationwide cohort study.
    BMJ Open 2017 Aug 11;7(8):e014807. Epub 2017 Aug 11.
    Biostatistics Centre College of Management, Taipei Medical University, Taipei, Taiwan.
    Objective: Studies on the risk of acute pancreatitis in patients with primary Sjogren's syndrome (pSS) are limited. We evaluated the effects of pSS on the risk of acute pancreatitis in a nationwide, population-based cohort in Taiwan.

    Study Design: Population-based retrospective cohort study. Read More

    P2X7 receptor antagonism prevents IL-1β release from salivary epithelial cells and reduces inflammation in a mouse model of autoimmune exocrinopathy.
    J Biol Chem 2017 Aug 10. Epub 2017 Aug 10.
    University of Missouri, United States;
    Salivary gland inflammation is a hallmark of Sjogrens syndrome (SS), a common autoimmune disease characterized by lymphocytic infiltration of the salivary gland and loss of saliva secretion, predominantly in women. The P2X7 receptor (P2X7R) is an ATP-gated non-selective cation channel that induces inflammatory responses in cells and tissues, including salivary gland epithelium. In immune cells, P2X7R activation induces the production of proinflammatory cytokines, including IL-1β and IL-18, by inducing the oligomerization of the multiprotein complex NLRP3-type inflammasome. Read More

    The TFOS Dry Eye Workshop II: Executive Summary.
    Ocul Surf 2017 Aug 7. Epub 2017 Aug 7.
    Schepens Eye Research Institute, Massachusetts Eye and Ear, and Department of Ophthalmology, Harvard Medical School, Boston, MA, USA. Electronic address:
    This article presents an Executive Summary of the conclusions and recommendations of the 10-chapter TFOS DEWS II report. The entire TFOS DEWS II report was published in the July 2017 issue of The Ocular Surface. A downloadable version of the document and additional material, including videos of diagnostic and management techniques, are available on the TFOS website: www. Read More

    Itolizumab in Psoriasis.
    Indian J Dermatol 2017 Jul-Aug;62(4):418-421
    Department of Skin and VD, JNU Institute for Medical Sciences and Research Centre, Jaipur, Rajasthan, India.
    A number of biologics is being used for the treatment of psoriasis. Itolizumab is one such agent which has been approved in India. It is an anti-CD6 monoclonal antibody that acts by binding to scavenger receptor cysteine-rich (SRCR) distal domain 1 of CD6. Read More

    Chronic Autoimmune Epithelitis in Sjögren's Syndrome and Primary Biliary Cholangitis: A Comprehensive Review.
    Rheumatol Ther 2017 Aug 8. Epub 2017 Aug 8.
    Division of Rheumatology, Allergy, and Clinical Immunology, University of California, Davis, CA, USA.
    Within the spectrum of autoimmune diseases, Sjögren's syndrome and primary biliary cholangitis are exemplary and can be coined as chronic epithelitis based on their frequent coexistence in clinical practice and the highly specific immune-mediated injury of the small bile ducts and the exocrine glands. The pathogenic mechanisms underlying the diseases are similar, with apoptosis being the key element leading to organ-specific immune-mediated injury directed against the small bile ducts and salivary gland epithelia, respectively along with similar epidemiological features, such as female predominance and the age of onset in the fifth decade of life. Indeed, novel insights into the pathogenesis of the diseases have been obtained in recent years, including a better definition of the role of B and T cells, particularly Th17 cells, and the mechanisms of autoantibody-mediated tissue injury, with anti-mitochondrial antibodies and SS-A/SS-B being identified as specific for primary biliary cholangitis and Sjögren's syndrome, respectively. Read More

    Long-term follow-up in primary Sjögren's syndrome reveals differences in clinical presentation between female and male patients.
    Biol Sex Differ 2017 Aug 8;8(1):25. Epub 2017 Aug 8.
    Unit of Experimental Rheumatology, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, SE-171 76, Stockholm, Sweden.
    Background: Despite men being less prone to develop autoimmune diseases, male sex has been associated with a more severe disease course in several systemic autoimmune diseases. In the present study, we aimed to investigate differences in the clinical presentation of primary Sjögren's syndrome (pSS) between the sexes and establish whether male sex is associated with a more severe form of long-term pSS.

    Methods: Our study population included 967 patients with pSS (899 females and 68 males) from Scandinavian clinical centers. Read More

    Salivary gland ultrasonography as a predictor of clinical activity in Sjögren's syndrome.
    PLoS One 2017 4;12(8):e0182287. Epub 2017 Aug 4.
    Department of Evidence-Based Medicine, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil.
    Purpose: Primary Sjögren's syndrome is a multisystem autoimmune disease characterized by hypofunction of salivary and lacrimal glands and possible multi-organ system manifestations. Over the past 15 years, three sets of diagnostic criteria have been proposed, but none has included salivary gland ultrasonography. However, recent studies support its role in the diagnosis and prognostic evaluation of patients with Sjögren's syndrome. Read More

    The PDGFRα-laminin B1-keratin 19 cascade drives tumor progression at the invasive front of human hepatocellular carcinoma.
    Oncogene 2017 Aug 7. Epub 2017 Aug 7.
    Department of Imaging and Pathology, KU Leuven and University Hospitals Leuven, Leuven, Belgium.
    Human hepatocellular carcinomas (HCCs) expressing the biliary/hepatic progenitor cell marker keratin 19 (K19) have been linked with a poor prognosis and exhibit an increase in platelet-derived growth factor receptor α (PDGFRα) and laminin beta 1 (LAMB1) expression. PDGFRα has been reported to induce de novo synthesis of LAMB1 protein in a Sjogren syndrome antigen B (La/SSB)-dependent manner in a murine metastasis model. However, the role of this cascade in human HCC remains unclear. Read More

    Adult's onset Still disease occurring during pregnancy: Case-report and literature review.
    Semin Arthritis Rheum 2017 Jul 10. Epub 2017 Jul 10.
    Service de Médecine Interne and Inflammation-Immunopathology-Biotherapy Department (DHU i2B), AP-HP, Hôpital Saint-Antoine, Sorbonne Universités, UPMC University Paris 06, F-75012, Paris, France.
    Introduction: Adult onset Still's disease is a rare affection classified among non-hereditary autoinflammatory diseases. We here report a case of AOSD revealed during pregnancy with a life-threatening presentation along with a review of 19 cases from literature.

    Case: A 38-years old woman was treated in our department for diffuse systemic sclerosis and associated Sjögren syndrome. Read More

    MTHFR gene variants and non-MALT lymphoma development in primary Sjogren's syndrome.
    Sci Rep 2017 Aug 4;7(1):7354. Epub 2017 Aug 4.
    Department of Physiology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
    Primary Sjogren's syndrome (pSS) confers increased risk for non-Hodgkin lymphoma (NHL) development. Two common polymorphisms, the c. 677C > T and c. Read More

    Cancer and Autoimmune Diseases.
    Autoimmun Rev 2017 Aug 1. Epub 2017 Aug 1.
    Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel; Sackler Faculty in Medicine, Sheba Medical Center, Tel-Aviv University, Israel.
    Purpose Of Review: The association between autoimmunity and cancer is well established. Cancer has been implicated in some autoimmune disorders (AID), such as scleroderma and myositis. On the other hand, many autoimmune disorders and immunosuppressive therapy, have been linked to an increased risk for cancer. Read More

    Prevalence of rheumatic diseases in adult population in Spain (EPISER 2016 study): Aims and methodology.
    Reumatol Clin 2017 Jul 31. Epub 2017 Jul 31.
    Servicio de Reumatología, Hospital Universitario de Canarias, La Laguna, Santa Cruz de Tenerife, España. Electronic address:
    Aims: To describe the methodology of the EPISER 2016 (study of the prevalence of rheumatic diseases in adult population in Spain), as well its strengths and limitations. The aim of this study is to estimate the prevalence of rheumatoid arthritis (RA), psoriatic arthritis (PsA), ankylosing spondylitis (AS), systemic lupus erythematosus (SLE), Sjögren's syndrome (SS), osteoarthritis (knee, hip, hands, and cervical and lumbar spine), fibromyalgia, gout and clinical osteoporotic fracture.

    Material And Method: Population-based, multicenter, cross-sectional study, with the participation of 45 municipalities in the 17 Spanish autonomous communities. Read More

    Ultrasound in Arthritis.
    Radiol Clin North Am 2017 Sep 12;55(5):985-996. Epub 2017 Jun 12.
    Nuffield Orthopaedic Centre, Oxford University Hospitals NHS Trust, Windmill Road, Oxford, OX3 7LD, UK.
    Ultrasound is currently performed in everyday rheumatologic practice. It is used for early diagnosis, to monitor treatment results, and to diagnose remission. The spectrum of pathologies seen in arthritis with ultrasound includes early inflammatory features and associated complications. Read More

    Lymphocytic hidradenitis: A distinctive histopathological finding of annular erythema of Sjögren syndrome.
    Australas J Dermatol 2017 Aug 3. Epub 2017 Aug 3.
    College of Medicine, Chang Gung University, Taoyuan, Taiwan.
    Background/objectives: Lymphocytic hidradenitis is a non-specific histopathological feature observed in many dermatoses such as lupus erythematosus, morphea or scleroderma. When it occurs it is usually accompanied by the other distinctive histological features of those conditions. Isolated lymphocytic hidradenitis is uncommon and its clinical features and associated underlying medical conditions are still undetermined. Read More

    The interaction between anti-Ro/SSA and anti-La/SSB autoantibodies and anti-infectious antibodies in a wide spectrum of auto-immune diseases: another angle of the autoimmune mosaic.
    Clin Exp Rheumatol 2017 Jul 6. Epub 2017 Jul 6.
    Zabludowicz Center for Autoimmune Diseases, Chaim Sheba Medical Center; Sackler Faculty of Medicine, Tel-Aviv University; and Incumbent of the Laura Schwarz-KipChair for Research of Autoimmune Diseases, Tel-Aviv University, Israel.
    Objectives: The presence of anti-Ro/SSA and anti-La/SSB antibodies has been linked with autoimmunity in general and with several autoimmune diseases (AID) in particular. In the current study we evaluated these antibodies in a wide spectrum of AID as well as the links between them and anti-infectious antibodies.

    Methods: We examined 2082 sera from patients with 16 different AID compared to 524 sera from geographically-matched healthy controls, for the presence and titres of anti-Ro/SSA and anti-La/SSB. Read More

    Effectiveness of Traditional Chinese Medicine Compound JieDuTongLuoShengJin Granules Treatment in Primary Sjögren's Syndrome: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.
    Evid Based Complement Alternat Med 2017 10;2017:1315432. Epub 2017 Jul 10.
    Department of Ophthalmology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China.
    Objective: To evaluate the clinical therapeutic efficacy and safety of JieDuTongLuoShengJin granules + HCQ in patients with pSS.

    Methods: 40 patients with low-activity-level pSS and without visceral involvement participated in this study and were randomized to receive either JieDuTongLuoShengJin granules with HCQ or placebo with HCQ. Patients and investigators were blinded to treatment allocation. Read More

    Is primary Sjögren's syndrome a risk factor for malignancies different from lymphomas? What does the literature highlight about it?
    Reumatologia 2017 18;55(3):136-139. Epub 2017 Jul 18.
    Internal Medicine and Endocrinology Department, Fattouma Bourguiba University Hospital, Monastir, Tunisia.
    Background: Primary Sjögren's syndrome (pSS) is a chronic systemic autoimmune disease with an elevated risk of developing lymphoproliferative malignancies (LM). Whether pSS is a risk factor or not for non-lymphoma malignancies (NLM) has been scarcely evaluated in the literature. Age is per se a risk factor for malignancies: patients over 70 years old have 4 times higher risk for cancers than adults. Read More

    The prevalence of ANA antibodies, anticentromere antibodies, and anti-cyclic citrullinated peptide antibodies in patients with primary Sjögren's syndrome compared to patients with dryness symptoms without primary Sjögren's syndrome confirmation.
    Reumatologia 2017 18;55(3):113-119. Epub 2017 Jul 18.
    Early Arthritis Clinic, National Institute of Geriatrics, Rehabilitation and Rheumatology, Warsaw, Poland.
    Objectives: Our study analyses the prevalence of ANA, anti-SS-A, anti-SS-B, and ACA and ACPA antibodies in patients with pSS and with dryness symptoms without pSS confirmation, and the association of ACPA and ACA antibodies with specific clinical symptoms.

    Materials And Methods: 113 patients were divided into two groups: I - with diagnosed pSS (N = 75); and II - with dryness without pSS evidence (N = 38). Diagnostics: indirect immunofluorescence (IF; Hep-2 cell line) of antinuclear antibodies (ANA), anti-SS-A anti-SS-B antibodies determined with semi-quantitative method, autoantibody profile (14 antigens, ANA Profil 3 EUROLINE); basic laboratory, ophthalmic examination tests, minor salivary gland biopsy with focus score (FS), joint and lung evaluation, and ESSDAI questionnaire (pSS activity). Read More

    Comparisons of neutrophil-, monocyte-, eosinophil-, and basophil- lymphocyte ratios among various systemic autoimmune rheumatic diseases.
    APMIS 2017 Aug 2. Epub 2017 Aug 2.
    Department of Laboratory Diagnostics, Changzheng Hospital, Second Military Medical University, Shanghai, China.
    This study was aimed to evaluate levels of neutrophil- (NLR), monocyte- (MLR), eosinophil- (ELR), and basophil-lymphocyte ratio (BLR) and their association with inflammatory markers in systemic autoimmune rheumatic diseases (SARDs). A total of 1139 SARD patients and 170 healthy individuals were enrolled. Clinical and laboratory data were extracted. Read More

    Gulf War illness (GWI) as a neuroimmune disease.
    Exp Brain Res 2017 Jul 31. Epub 2017 Jul 31.
    Brain Sciences Center (11B), Minneapolis Veterans Affairs Health Care System, One Veterans Drive, Minneapolis, MN, 55417, USA.
    Gulf War illness (GWI) is a chronic disease characterized by the involvement of several organs, including the brain (Christova et al., Exp Brain Res doi: 10.1007/s00221-017-5010-8 , 2017). Read More

    H1N1 vaccination in Sjögren's syndrome triggers polyclonal B cell activation and promotes autoantibody production.
    Ann Rheum Dis 2017 Jul 31. Epub 2017 Jul 31.
    Department of Medicine, Karolinska University Hosptial, Karolinska Institutet, Stockholm, Sweden.
    Objectives: Vaccination of patients with rheumatic disease has been reported to result in lower antibody titres than in healthy individuals. However, studies primarily include patients on immunosuppressive therapy. Here, we investigated the immune response of treatment-naïve patients diagnosed with primary Sjögren's syndrome (pSS) to an H1N1 influenza vaccine. Read More

    Ultrasonography of major salivary glands compared with parotid and labial gland biopsy and classification criteria in patients with clinically suspected primary Sjögren's syndrome.
    Ann Rheum Dis 2017 Jul 28. Epub 2017 Jul 28.
    Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
    Objective: To assess the validity of ultrasound of major salivary glands (sUS) compared with parotid and labial gland biopsies, sialometry, anti-SSA/Ro antibody status and classification criteria in patients clinically suspected with primary Sjögren's syndrome (pSS).

    Methods: 103 consecutive outpatients with clinically suspected pSS underwent sUS. Parenchymal echogenicity, homogeneity, hypoechogenic areas, hyperechogenic reflections and clearness of salivary gland border were scored according to the Hocevar scoring system. Read More

    Effect of anti-muscarinic autoantibodies on leukocyte function in Sjögren's syndrome.
    Mol Immunol 2017 Jul 24;90:136-142. Epub 2017 Jul 24.
    Department of Physiology, School of Dentistry, Seoul National University and Dental Research Institute, Seoul, 110-749, Korea. Electronic address:
    Patients with primary Sjögren's syndrome, a systemic autoimmune disease, have been shown to have serum autoantibodies that react with the muscarinic acetylcholine type 3 receptor (M3R).Primary Sjögren's syndrome is a systemic autoimmune disease. Patients with primary Sjögren's syndrome have been shown to have serum autoantibodies that react with the muscarinic acetylcholine type 3 receptor (M3R). Read More

    Clinical characteristics of autoimmune rheumatic disease-related organizing pneumonia.
    Clin Rheumatol 2017 Jul 26. Epub 2017 Jul 26.
    Department of Rheumatology, Beijing Chao-yang Hospital, Capital Medical University, #8 Gong-Ti South Road, Chaoyang District, Beijing, 100020, China.
    To study the clinical characteristics of autoimmune rheumatic disease-related organizing pneumonia (AIRD-OP), the clinical presentation, radiological findings, treatment, and outcome of AIRD-OP patients were analyzed, in comparison with patients with cryptogenic organizing pneumonia (COP). A total of 131 OP patients were identified, including 57 cases of AIRD-OP, 35 cases of COP, and 39 cases of other disease-related OPs. Among AIRD-OP patients, 36 (63%) presented the symptoms of OP at onset. Read More

    Presence of BPIFB1 in saliva from non-obese diabetic mice.
    Odontology 2017 Jul 26. Epub 2017 Jul 26.
    Division of Oral and Maxillofacial Radiology, Niigata University Graduate School of Medical and Dental Science, 2-5274 Gakkocho-dori, Chuo-ku, Niigata, 951-8514, Japan.
    We previously showed that mRNA expression of BPIFB1 (Bpifb1), an antibacterial protein in the palate, lung, and nasal epithelium clone protein family, was increased in parotid acinar cells in non-obese diabetic (NOD, NOD/ShiJcl) mice, which is an animal model for Sjögren's syndrome. However, we did not previously assess the protein levels. In this report, we confirmed the expression of BPIFB1 protein in the parotid glands of NOD mice. Read More

    Comorbid autoimmune diseases in patients with pemphigus: a nationwide case-control study in Taiwan.
    Eur J Dermatol 2017 Jul 27. Epub 2017 Jul 27.
    Department of Dermatology, Taipei Veterans General Hospital, Taipei, Taiwan, Department of Dermatology, National Yang-Ming University, Taipei, Taiwan.
    Previous studies have proposed the association between pemphigus and several autoimmune diseases, but no large-scale study has been reported. To delineate the association between pemphigus and autoimmune diseases including psoriasis. A total of 1,998 patients with pemphigus and 7,992 control subjects were enrolled from the National Health Insurance Research Database in Taiwan from 1997 to 2010. Read More

    Extended high-frequency audiometry as early detection of hearing loss in primary Sjögren syndrome.
    Clin Rheumatol 2017 Jul 26. Epub 2017 Jul 26.
    Department of Otolaryngology-Head and Neck Surgery, University of Nuevo Leon, Medicine School and University Hospital, Av. Madero y Gonzalitos Colonia Mitras Centro CP, 64460, Monterrey, NL, Mexico.
    The aim of the study is to evaluate hearing function by extended high-frequency audiometry in primary Sjögren Syndrome (pSS) and to correlate it with disease activity. All patients diagnosed with pSS were recruited within 1 year. Patients underwent otologic evaluation, extended high-frequency audiometry, tympanogram, and the ESSPRI scale evaluation. Read More

    Primary Sjogren's Syndrome Associated With Treatment-Resistant Obsessive-Compulsive Disorder.
    Front Psychiatry 2017 11;8:124. Epub 2017 Jul 11.
    Centre for Immunology, Westmead Institute for Medical Research, University of Sydney, Sydney, NSW, Australia.
    There is an increasing awareness that autoimmune diseases can present with neuropsychiatric manifestations. We present the case of a 17-year-old female requiring psychiatric hospitalization for obsessive-compulsive disorder and major depressive disorder with mixed affective features, who was subsequently diagnosed with primary Sjogren's syndrome. Treatment with potent immunosuppression resulted in remission of psychiatric illness. Read More

    Corneal melting after cataract surgery in a patient with autoimmune disease.
    Arch Soc Esp Oftalmol 2017 Jul 22. Epub 2017 Jul 22.
    Servicio de Superficie Ocular y Córnea, Centro de Oftalmología Barraquer, Barcelona, España.
    Case Report: A 78-year-old woman with rheumatoid arthritis and secondary Sjögren's syndrome presented with corneal melting three days after cataract extraction that required penetrating keratoplasty. By the fourth month, a second corneal transplant was needed due to a new descemetocele associated with her systemic disease.

    Discussion: The underlying disease, together with the surgical history, was responsible for the complication presented. Read More

    CD4 T lymphocyte autophagy is upregulated in the salivary glands of primary Sjögren's syndrome patients and correlates with focus score and disease activity.
    Arthritis Res Ther 2017 Jul 25;19(1):178. Epub 2017 Jul 25.
    Dipartimento di Medicina Interna e Specialità Mediche, Sapienza Università di Roma, Rome, Italy.
    Background: Primary Sjögren's syndrome (pSS) is a common chronic autoimmune disease characterized by lymphocytic infiltration of exocrine glands and peripheral lymphocyte perturbation. In the current study, we aimed to investigate the possible pathogenic implication of autophagy in T lymphocytes in patients with pSS.

    Methods: Thirty consecutive pSS patients were recruited together with 20 patients affected by sicca syndrome and/or chronic sialoadenitis and 30 healthy controls. Read More

    Bruton's tyrosine kinase inhibitor BMS-986142 in experimental models of rheumatoid arthritis enhances efficacy of agents representing clinical standard-of-care.
    PLoS One 2017 24;12(7):e0181782. Epub 2017 Jul 24.
    Immunosciences Discovery Biology, Bristol-Myers Squibb Research & Development, Princeton, New Jersey, United States of America.
    Bruton's tyrosine kinase (BTK) regulates critical signal transduction pathways involved in the pathobiology of rheumatoid arthritis (RA) and other autoimmune disorders. BMS-986142 is a potent and highly selective reversible small molecule inhibitor of BTK currently being investigated in clinical trials for the treatment of both RA and primary Sjögren's syndrome. In the present report, we detail the in vitro and in vivo pharmacology of BMS-986142 and show this agent provides potent and selective inhibition of BTK (IC50 = 0. Read More

    TFOS DEWS II pathophysiology report.
    Ocul Surf 2017 Jul 20;15(3):438-510. Epub 2017 Jul 20.
    Schepens Eye Research Institute & Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA.
    The TFOS DEWS II Pathophysiology Subcommittee reviewed the mechanisms involved in the initiation and perpetuation of dry eye disease. Its central mechanism is evaporative water loss leading to hyperosmolar tissue damage. Research in human disease and in animal models has shown that this, either directly or by inducing inflammation, causes a loss of both epithelial and goblet cells. Read More

    A systematic review of primary Sjögren's syndrome in male and paediatric populations.
    Clin Rheumatol 2017 Jul 22. Epub 2017 Jul 22.
    Department of Rheumatology, University College London, 250 Euston Road, London, NW1 2PG, UK.
    Primary Sjögren's syndrome (pSS) is a chronic multisystem autoimmune rheumatic disease characterised by female predominance. Although the disease is rare in the male and paediatric populations, it has been suggested that it may have a different disease phenotype, which has not been investigated before using a systematic approach. A systematic literature search of PubMed databases (updated to December 2016) was performed to identify all published data on the epidemiological, clinical and laboratory manifestations of pSS in the male and paediatric populations. Read More

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