17,842 results match your criteria Sjogren Syndrome


Long-term renal prognosis among patients with primary Sjögren's syndrome and renal involvement: A nationwide matched cohort study.

J Autoimmun 2020 May 21:102483. Epub 2020 May 21.

Division of Rheumatology, Allergy and Immunology, Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan; Center for Mitochondrial Research and Medicine, Kaohsiung Chang Gung Memorial Hospital, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan. Electronic address:

Background: The long-term renal outcome in patients with primary Sjögren's syndrome (pSS) remains uncertain. We aimed to determine the absolute incidence and relative risk of chronic kidney disease (CKD) and end-stage renal disease (ESRD) in patients with pSS at the general population level.

Methods: We performed a retrospective cohort study using a national health insurance database in Taiwan from 2000 to 2013. Read More

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http://dx.doi.org/10.1016/j.jaut.2020.102483DOI Listing

Epigenetics in Primary Sjögren's Syndrome.

Adv Exp Med Biol 2020 ;1253:285-308

INSERM U1227, «Lymphocyte B et autoimmunité», Labex Igo "Immunotherapy Graft, Oncology", Réseau épigénétique du cancéropole Grand Ouest, Université de Brest, Brest, France.

Primary Sjögren's syndrome (SjS) is a chronic and systemic autoimmune epithelitis with predominant female incidence, which is characterized by exocrine gland dysfunction. Incompletely understood, the etiology of SjS is multi-factorial and evidence is growing to consider that epigenetic factors are playing a crucial role in its development. Independent from DNA sequence mutations, epigenetics is described as inheritable and reversible processes that modify gene expression. Read More

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http://dx.doi.org/10.1007/978-981-15-3449-2_11DOI Listing
January 2020

Epigenetic Methods and Twin Studies.

Adv Exp Med Biol 2020 ;1253:95-104

Humanitas Clinical and Research Center-IRCCS, via Manzoni 56, 20089, Rozzano, Milan, Italy.

Genomic predisposition fails to fully explain the onset of complex diseases, which is well illustrated by the largely incomplete concordance among monozygotic twins. Epigenetic mechanisms, including DNA methylation, chromatin remodeling, and non-coding RNA, are the link between environmental stimuli and disease onset on a permissive genetic background in autoimmune and chronic inflammatory diseases. Autoimmune diseases now include almost 100 conditions and are estimated to cumulatively affect up to 5% of the world population with a healthcare expenditure superior to cancer worldwide. Read More

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http://dx.doi.org/10.1007/978-981-15-3449-2_3DOI Listing
January 2020

Study on the correlation between anti-ribosomal P protein antibody and systemic lupus erythematosus.

Medicine (Baltimore) 2020 May;99(20):e20192

The aims of this study were to compare diagnostic value of anti-ribosomal P protein antibody (anti-P), anti-Smith antibody (anti-Sm), anti-double-stranded DNA antibody (anti-dsDNA), anti-nucleosome antibody (ANuA), and anti-histone antibody (AHA) for systemic lupus erythematosus (SLE) as well as explore the correlation between anti-P and SLE.A retrospective study was performed with 487 SLE patients, 235 non-SLE rheumatic diseases, and 124 healthy subjects from January 2015 to December 2018. Clinical manifestations, laboratory results and Systemic Lupus Erythematosus Disease Activity Index (SLEDAI)-2000 scores were analyzed between anti-P/+/ and anti-P/-/ patients. Read More

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http://dx.doi.org/10.1097/MD.0000000000020192DOI Listing

Shrinking Lung Syndrome in Primary Sjögren Syndrome.

Balkan Med J 2020 May 22. Epub 2020 May 22.

Department of Rheumatology, Internal Medicine, Dokuz Eylül University School of Medicine, İzmir, Turkey.

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http://dx.doi.org/10.4274/balkanmedj.galenos.2020.2020.4.143DOI Listing

Bilateral facial palsy as the first presentation of primary Sjögren's syndrome: a case report and review of literature.

Acta Neurol Belg 2020 May 21. Epub 2020 May 21.

Clinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

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http://dx.doi.org/10.1007/s13760-020-01372-9DOI Listing

Histopathological changes in tear-secreting tissues and cornea in a mouse model of autoimmune disease.

Exp Biol Med (Maywood) 2020 May 21:1535370220928275. Epub 2020 May 21.

Laboratory of Anatomy, Department of Basic Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Sapporo 060-0618, Japan.

Impact Statement: Cornea, an outermost layer of mammalian eye, is protected by tear film and abnormalities of tear film causes dry eye. Dry eye injures the cornea which results lower vision in patients. Several factors cause dry eye, including altered systemic conditions, environment, and immunological abnormality of the patient in autoimmune disease like Sjögren's syndrome (SS). Read More

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http://dx.doi.org/10.1177/1535370220928275DOI Listing

Analysis of clinical and laboratory characteristics and pathology of lupus nephritis-based on 710 renal biopsies in China.

Clin Rheumatol 2020 May 20. Epub 2020 May 20.

Department of Nephrology, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Diseases, Medical School of Chinese PLA, the First Medical Centre, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, China.

Objectives: This study aimed to analyse the clinical and laboratory characteristics of different pathologic classifications of lupus nephritis (LN) patients in terms of age at systemic lupus erythematosus (SLE) diagnosis and nephritis onset.

Method: Clinical, laboratory, and pathological data of 710 LN patients diagnosed by renal biopsy at our institution between 2000 and 2018 were retrospectively analysed. Patients were divided into the different pathological classification groups; childhood-, adult- and elderly-onset SLE groups and early- and late-onset LN groups. Read More

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http://dx.doi.org/10.1007/s10067-020-05115-2DOI Listing

MR imaging findings of calcinosis cutis in primary Sjogren syndrome, a rare manifestation.

Radiol Case Rep 2020 Jul 15;15(7):1029-1038. Epub 2020 May 15.

Department of Surgery, UF Health Jacksonville, Jacksonville, FL 32209, USA.

Soft tissue calcifications associated with various connective tissue diseases such as dermatomyositis and scleroderma have been well documented Plaque-like sheets of subcutaneous calcifications presenting as an indurated soft tissue mass in a patient with primary Sjogren syndrome have been rarely documented in the literature. We present the magnetic resonance and conventional radiographic findings of calcinosis cutis and calcinosis circumscripta of a 47-year-old woman with biopsy proven Sjogren syndrome. We also delineate various types of soft tissue calcification, histopathology of calcinosis cutis, and current treatment options. Read More

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http://dx.doi.org/10.1016/j.radcr.2020.04.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229417PMC

EBV and CMV Viral Load in Rheumatoid Arthritis and Their Role Associated Sjögren's Syndrome.

J Oral Pathol Med 2020 May 19. Epub 2020 May 19.

Oral Medicine Unit, Departmento de Clínica e Odontologia Preventiva, Universidade Federal de Pernambuco, Recife, Brazil.

Introduction: The role of viral infections in the pathogenesis of autoimmune diseases has long been suggested, but little evidence is available.

Objective: This study aimed to evaluate an association between EBV and CMV and the presence of rheumatoid arthritis and its association with Sjögren's Syndrome.

Patients And Method: A case-control study was performed with 227 patients divided in RA (n=99), RA/SS (n = 20) and C (n = 128). Read More

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http://dx.doi.org/10.1111/jop.13036DOI Listing

Peritoneal Carcinomatosis in an Adult With Sjögren's Syndrome: A Diagnostic Dilemma Revealing a Rare Association With Primary Gastric Adenocarcinoma.

Authors:
Dawood Findakly

Cureus 2020 May 14;12(5):e8123. Epub 2020 May 14.

Internal Medicine, Creighton University Arizona Health Education Alliance/Valleywise Health Medical Center, Phoenix, USA.

Sjögren's syndrome (SS) is a systemic autoimmune disease that mainly affects middle-aged women. It is rarely associated with solid neoplasms. We report a 60-year-old woman with a past medical history relevant for SS who was diagnosed with advanced-stage gastric adenocarcinoma upon evaluating for peritoneal carcinomatosis and succumbed two months after her original diagnosis. Read More

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http://dx.doi.org/10.7759/cureus.8123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7228793PMC

Storm, typhoon, cyclone or hurricane in patients with COVID-19? Beware of the same storm that has a different origin.

RMD Open 2020 05;6(1)

University of Oviedo, Instituto de Investigación Sanitaria del Principado de Asturias, Oviedo, Spain.

Some of the articles being published during the severe acute respiratory syndrome-coronavirus (SARS-CoV)-2 pandemic highlight a link between severe forms of coronavirus disease 2019 (COVID-19) and the so-called cytokine storm, also with increased ferritin levels. However, this scenario is more complex than initially thought due to the heterogeneity of hyperinflammation. Some patients with coronavirus 2019 disease (COVID-19) develop a fully blown secondary haemophagocytic lymphohistiocytosis (sHLH), whereas others, despite a consistent release of pro-inflammatory cytokines, do not fulfil sHLH criteria but still show some features resembling the phenotype of the hyperferritinemic syndrome. Read More

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http://dx.doi.org/10.1136/rmdopen-2020-001295DOI Listing

Clinical, Radiological, and Laboratory Features of Spinal Cord Involvement in Primary Sjögren's Syndrome.

J Clin Med 2020 May 14;9(5). Epub 2020 May 14.

. Department of Neurology, Otto-von-Guericke University, 39120 Magdeburg, Germany.

Objective: To identify radiological and laboratory hallmarks in patients with primary Sjögren's syndrome (pSS) presenting with spinal cord involvement.

Methods: Clinical and laboratory routine parameters were analyzed in a retrospective multicenter case series of four patients who developed myelitis associated with pSS. Serological and cerebrospinal fluid (CSF) measurements of pSS associated anti-SSA(Ro)-antibodies were initiated, and CSF neurofilament light chain (NFL) levels were assessed. Read More

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http://dx.doi.org/10.3390/jcm9051482DOI Listing

Rituximab or cyclosporin in refractory immune thrombocytopenia secondary to connective tissue diseases: a real-world observational retrospective study.

Clin Rheumatol 2020 May 16. Epub 2020 May 16.

Department of Rheumatology, South Campus, Ren Ji Hospital, School of Medicine, Shanghai Jiaotong University, Jiang Yue Road 2000, Shanghai, 201112, China.

Immune thrombocytopenia (ITP) is a common complication of connective tissue diseases (CTD). However, refractory and recurrent cases are frequent, who often need intensive immunotherapy. In the real world to compare the efficacy and safety of two common options, rituximab (RTX) and cyclosporine (CsA), in patients with refractory CTD-ITP, we conducted this retrospective study. Read More

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http://dx.doi.org/10.1007/s10067-020-05152-xDOI Listing

Immune-mediated axonal dysfunction in seropositive and seronegative primary Sjögren's syndrome.

Ann Clin Transl Neurol 2020 May 15. Epub 2020 May 15.

Department of Neurology, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.

Objective: The present study investigates the peripheral neuropathy in Primary Sjögren's syndrome (pSS) using the nerve excitability test to further elucidate how peripheral nerves are affected by the autoantibodies.

Methods: Each patient received clinical evaluation, examination for anti-SSA/Ro and anti-SSB/La antibodies titer, paired motor and sensory nerve excitability test, thermal quantitative sensory test (QST), and nerve conduction study (NCS).

Results: A total of 40 pSS patients wasenrolled. Read More

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http://dx.doi.org/10.1002/acn3.51053DOI Listing

Role of Viral Infections in the Pathogenesis of Sjögren's Syndrome: Different Characteristics of Epstein-Barr Virus and HTLV-1.

J Clin Med 2020 May 13;9(5). Epub 2020 May 13.

Department of Immunology and Rheumatology, Unit of Advanced Preventive Medical Sciences, Division of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8501, Japan.

Viruses are possible pathogenic agents in several autoimmune diseases. Sjögren's syndrome (SS), which involves exocrine dysfunction and the appearance of autoantibodies, shows salivary gland- and lacrimal gland-oriented clinical features. Epstein-Barr virus (EBV) is the most investigated pathogen as a candidate that directly induces the phenotype found in SS. Read More

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http://dx.doi.org/10.3390/jcm9051459DOI Listing

Comparison of Clinical Characteristics and Magnetic Resonance Imaging of Salivary Glands With Magnetic Resonance Sialography in Sjögren's Syndrome.

Laryngoscope 2020 May 15. Epub 2020 May 15.

Department of Allergology and Clinical Immunology, Geneva University Hospitals, Geneva, Switzerland.

Objectives/hypothesis: To compare the results of magnetic resonance imaging with magnetic resonance sialography (MRSIAL) and the clinical and laboratory characteristics in a well-characterized cohort of patients with primary or secondary Sjögren's syndrome (SS) meeting the American-European Consensus Group criteria.

Study Design: Retrospective, observational, monocentric study.

Methods: Thirty-six patients (81% female, mean age = 48 ± 35 years) with primary or secondary SS who underwent MRSIAL were included in the study. Read More

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http://dx.doi.org/10.1002/lary.28742DOI Listing

Refractive surgery for the patient with autoimmune diseases.

Curr Opin Ophthalmol 2020 May 13. Epub 2020 May 13.

Institute of Ophthalmology and Visual Science, Rutgers - New Jersey Medical School, Newark.

Purpose Of Review: Autoimmune and immune-mediated diseases are considered contraindications for laser refractive surgeries according to the US Food and Drug Administration's guideline. This guideline, however, is based on limited case reports or complications reported during other intraocular procedures. There have been only a handful of new clinical studies that evaluate the efficacy and safety of refractive surgery in this specific patient population. Read More

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http://dx.doi.org/10.1097/ICU.0000000000000668DOI Listing

Illness experiences of chilean women with sjögren's syndrome from the patient perspective.

Arthritis Care Res (Hoboken) 2020 May 14. Epub 2020 May 14.

Department of Oral Medicine and Pathology, Faculty of Dentistry, Universidad de Chile, Santiago, Chile.

Objective: Sjögren's syndrome challenges everyday functioning and well-being. The aim of this study was to structure and summarize the life experiences of Chilean women with Sjögren's Syndrome (SS) in an integrated model.

Methods: Interviews from a previous study yielded 75 experiences of living with SS. Read More

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http://dx.doi.org/10.1002/acr.24256DOI Listing

Total glucosides of paeony (TGP) alleviates Sjogren's syndrome through inhibiting inflammatory responses in mice.

Phytomedicine 2020 Mar 6;71:153203. Epub 2020 Mar 6.

State Key Laboratory of Natural Medicines, School of Basic Medical Sciences and Clinical Pharmacy, China Pharmaceutical University, Nanjing 210009, PR China. Electronic address:

Background: Sjogren's syndrome (SS) is an inflammatory autoimmune disease whose etiology is complicated. Total glucosides of paeony (TGP) has a variety of pharmacological effects.

Purpose: To evaluate the therapeutic effects of TGP on SS in mice and anti-inflammatory mechanism. Read More

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http://dx.doi.org/10.1016/j.phymed.2020.153203DOI Listing
March 2020
3.126 Impact Factor

Rationale for and clinical development of anti-fractalkine antibody in rheumatic diseases.

Expert Opin Biol Ther 2020 May 13:1-11. Epub 2020 May 13.

Division of Rheumatology, Department of Internal Medicine, Toho University School of Medicine, Tokyo, Japan.

: Rheumatic diseases are inflammatory diseases that damage target organs via multiple subsets of immune cells. Fractalkine (FKN) acts as chemoattractant as well as adhesion molecule. It contributes to the pathogenesis of rheumatoid arthritis (RA) and other rheumatic diseases through multiple mechanisms: the migration of monocytes and cytotoxic effector T cells, the proliferation and activation of fibroblast-like synoviocytes, angiogenesis, and osteoclastogenesis. Read More

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http://dx.doi.org/10.1080/14712598.2020.1764931DOI Listing

Sjögren-Larsson syndrome: The mild end of the phenotypic spectrum.

JIMD Rep 2020 May 25;53(1):61-70. Epub 2020 Mar 25.

Department of Pediatric Neurology Radboud University Medical Center, Amalia Children's Hospital, Donders Institute for Brain Cognition and Behaviour Nijmegen The Netherlands.

Sjögren-Larsson syndrome (SLS) is a rare inborn error of lipid metabolism. The syndrome is caused by mutations in the gene, resulting in a deficiency of fatty aldehyde dehydrogenase. Most patients have a clearly recognizable severe phenotype, with congenital ichthyosis, intellectual disability, and spastic diplegia. Read More

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http://dx.doi.org/10.1002/jmd2.12099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203653PMC

Immunobiology of T Cells in Sjögren's Syndrome.

Clin Rev Allergy Immunol 2020 May 11. Epub 2020 May 11.

Digestive Disease Institute, Guangzhou First People's Hospital and Institutes for Life Sciences, South China University of Technology, Guangzhou, 510006, China.

Sjögren's syndrome (SjS) is a systemic autoimmune disease marked by xerostomia (dry mouth), keratoconjunctivitis sicca (eye dryness), and other systematic disorders. Its pathogenesis involves an inflammatory process that is characterized by lymphocytic infiltration into exocrine glands and other tissues. Although the development of ectopic lymphoid tissue and overproduction of autoantibodies by hyperactive B cells suggest that they may promote SjS development, treatment directed towards them fails to induce significant laboratory or clinical improvement. Read More

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http://dx.doi.org/10.1007/s12016-020-08793-7DOI Listing

Quantitative analysis of Sjogren's syndrome related interstitial lung disease with different methods.

Eur J Radiol 2020 May 7;128:109030. Epub 2020 May 7.

Department of Rheumatology, University of Pamukkale, Kinikli, 20100 Denizli, Turkey.

Purpose: To investigate the success of different quantitative lung assessment (QLA) methods on high-resolution CT (HRCT) to assess the severity of Sjogren's syndrome (SjS) related interstitial lung disease (ILD).

Method: Consecutive SjS patients who underwent both thin-section HRCT and pulmonary function tests (PFTs) were investigated. The QLA was obtained using two different DICOM (digital imaging and communications in medicine) viewer with three different methods and lung histogram values. Read More

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http://dx.doi.org/10.1016/j.ejrad.2020.109030DOI Listing

Tirabrutinib: First Approval.

Authors:
Sohita Dhillon

Drugs 2020 Jun;80(8):835-840

Springer Nature, Private Bag 65901, Mairangi Bay, Auckland, 0754, New Zealand.

Tirabrutinib (Velexbru) is an orally administered, small molecule, Bruton's tyrosine kinase (BTK) inhibitor being developed by Ono Pharmaceutical and its licensee Gilead Sciences for the treatment of autoimmune disorders and haematological malignancies. Tirabrutinib irreversibly and covalently binds to BTK in B cells and inhibits aberrant B cell receptor signalling in B cell-related cancers and autoimmune diseases. In March 2020, oral tirabrutinib was approved in Japan for the treatment of recurrent or refractory primary central nervous system lymphoma. Read More

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http://dx.doi.org/10.1007/s40265-020-01318-8DOI Listing

Acquired anhidrosis in a patient with Sjogren syndrome and silicone breast implants.

JAAD Case Rep 2020 May 29;6(5):414-416. Epub 2020 Apr 29.

University of Rochester Medical Center, Rochester, New York.

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http://dx.doi.org/10.1016/j.jdcr.2020.02.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200200PMC

Renal Tubular Acidosis Causing Acute Hypokalemic Paralysis in Systemic Lupus Erythematosus: Sjogren's Syndrome Overlap.

Cureus 2020 Apr 6;12(4):e7555. Epub 2020 Apr 6.

Internal Medicine, Rochester General Hospital, Rochester, USA.

Acute hypokalemic paralysis (AHP) is a reversible medical emergency either caused by excessive loss of potassium ions (K+) or increased intracellular shift of K+. Distal renal tubular acidosis (RTA) is an important differential to rule out in patients presenting with AHP. RTA is a constellation of disorders that have been associated with renal damage caused by autoimmune conditions such as systemic lupus erythematosus (SLE) and Sjögren's syndrome (SS). Read More

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http://dx.doi.org/10.7759/cureus.7555DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202574PMC

Gene Polymorphisms in Patients with Rheumatoid Arthritis.

Int J Environ Res Public Health 2020 May 5;17(9). Epub 2020 May 5.

Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, 70-111 Szczecin, Poland.

Introduction: Rheumatoid arthritis (RA) is an important public health problem because this disease often causes disability. RA is a chronic, destructive autoimmune disease that leads to joint destruction and the development of extraarticular manifestations. is an intracellular signal transduction protein that plays a significant role in signal transduction in T cells and affects T cell development, proliferation and activation. Read More

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http://dx.doi.org/10.3390/ijerph17093214DOI Listing

Comprehensive Molecular Profiles of Functionally Effective MSC-Derived Extracellular Vesicles in Immunomodulation.

Mol Ther 2020 Apr 23. Epub 2020 Apr 23.

Department of Molecular and Cellular Medicine, Institute for Regenerative Medicine, College of Medicine, Texas A&M University, 1114 TAMU, 206 Olsen Boulevard, College Station, TX 77845, USA. Electronic address:

Accumulating evidence indicates that mesenchymal stem/stromal cell-derived extracellular vesicles (MSC-EVs) exhibit immunomodulatory effects by delivering therapeutic RNAs and proteins; however, the molecular mechanism underlying the EV-mediated immunomodulation is not fully understood. In this study, we found that EVs from early-passage MSCs had better immunomodulatory potency than did EVs from late-passage MSCs in T cell receptor (TCR)- or Toll-like receptor 4 (TLR4)-stimulated splenocytes and in mice with ocular Sjögren's syndrome. Moreover, MSC-EVs were more effective when produced from 3D culture of the cells than from the conventional 2D culture. Read More

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http://dx.doi.org/10.1016/j.ymthe.2020.04.020DOI Listing

T cell exosome-derived miR-142-3p impairs glandular cell function in Sjögren's syndrome.

JCI Insight 2020 May 7;5(9). Epub 2020 May 7.

Sjögren's Syndrome and Salivary Gland Dysfunction Unit.

Sjögren's syndrome (SS) is a systemic autoimmune disease that mainly affects exocrine salivary and lacrimal glands. Local inflammation in the glands is thought to trigger glandular dysfunction and symptoms of dryness. However, the mechanisms underlying these processes are incompletely understood. Read More

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http://dx.doi.org/10.1172/jci.insight.133497DOI Listing

Prevalence and risk factors of dry eye in 79,866 participants of the population-based Lifelines cohort study in the Netherlands.

Ocul Surf 2020 May 3. Epub 2020 May 3.

Section of Academic Ophthalmology, School of Life Course Sciences, Faculty of Life Sciences and Medicine (FoLSM), King's College London, St Thomas' Hospital, Lambeth Palace Road, Waterloo, London, SE1 7EH, United Kingdom; Department of Ophthalmology, King's College London, St Thomas' Hospital, Lambeth Palace Road, Waterloo, London, SE1 7EH, London, United Kingdom.

Purpose: To investigate the prevalence of dry eye among all adult age categories and to discover independent risk factors by investigating a wide range of etiological categories.

Methods: A cross-sectional association study including 79,866 voluntary participants aged 20-94 years of the population-based Lifelines Cohort Study in the Netherlands.

Results: Overall, 9. Read More

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http://dx.doi.org/10.1016/j.jtos.2020.04.005DOI Listing

Large granular lymphocytes (LGL) in primary Sjögren syndrome (pSS): immunophenotype and review on the pathological role of T cells in pSS.

Blood Res 2020 May 7. Epub 2020 May 7.

Department of Clinical and Experimental Medicine, Section of Haematology, University of Pisa, Italy.

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http://dx.doi.org/10.5045/br.2020.2020052DOI Listing

Enhancement in Xerostomia Patient Salivary Lubrication Using a Mucoadhesive.

J Dent Res 2020 May 6:22034520917675. Epub 2020 May 6.

Department of Biomedical Engineering, University of Groningen and University Medical Center Groningen, Groningen, the Netherlands.

Oral lubrication mediated by mucin and protein containing salivary conditioning films (SCFs) with strong water retainability can get impaired due to disease such as xerostomia, that is, a subjective dry mouth feel associated with the changed salivary composition and low salivary flow rate. Aberrant SCFs in xerostomia patient cause difficulties in speech, mastication, and dental erosion while the prescribed artificial saliva is inadequate to solve the complications on a lasting basis. With the growing aging population, it is urgently needed to propose a new strategy to restore oral lubrication. Read More

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http://dx.doi.org/10.1177/0022034520917675DOI Listing

Total glucosides of paeony: A review of its phytochemistry, role in autoimmune diseases, and mechanisms of action.

J Ethnopharmacol 2020 May 1;258:112913. Epub 2020 May 1.

Pharmacy College, Chengdu University of Traditional Chinese Medicine, State Key Laboratory of Characteristic Chinese Drug Resources in Southwest China, The Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, Chengdu 611137, China. Electronic address:

Ethnopharmacological Relevance: Paeoniae Radix Alba (PRA, called baishao in China), the root of Paeonia lactiflora Pall., has shown a rich medicinal value for more than 2000 years. PRA is used in local medicine and traditional medicine for autoimmune diseases associated with inflammation. Read More

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http://dx.doi.org/10.1016/j.jep.2020.112913DOI Listing
May 2020
2.998 Impact Factor

Metabolic abnormalities exacerbate Sjögren's syndrome by and is associated with increased the population of interleukin-17-producing cells in NOD/ShiLtJ mice.

J Transl Med 2020 May 5;18(1):186. Epub 2020 May 5.

The Rheumatism Research Center, Catholic Research Institute of Medical Science, College of Medicine, The Catholic University of Korea, Seoul, 06591, Republic of Korea.

Background: Sjögren's syndrome (SS) is an autoimmune disease mediated by lymphocytic infiltration into exocrine glands, resulting in progressive lacrimal and salivary destruction and dysfunctional glandular secretion. Metabolic syndrome influences the immune system. To investigate its relationship with metabolic abnormalities, we evaluated the pathogenesis of SS and the immune cell populations in non-obese diabetic NOD/ShiLtJ mice with type 1 diabetes (T1D). Read More

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http://dx.doi.org/10.1186/s12967-020-02343-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201776PMC

[A case of pulmonary amyloidosis with Sjögren's syndrome].

Zhonghua Nei Ke Za Zhi 2020 May;59(5):385-387

Department of Pneumology, The First Hospital of Shanxi Medical University, Taiyuan 030000, China.

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http://dx.doi.org/10.3760/cma.j.cn112138-20190525-00376DOI Listing

In vitro three-dimensional culture systems of salivary glands.

Pathol Int 2020 May 4. Epub 2020 May 4.

Division of Pathology, Department of Oral Diagnostic Sciences, Showa University School of Dentistry, Tokyo, Japan.

Dry mouth can be caused by salivary gland hypofunction due to Sjögren's syndrome (SS) or radiation therapy for head and neck cancer, and it can also be a side effect of medications. The use of sialagogues effectively increases saliva secretion in patients with dry mouth. However, the application of sialagogues is not always satisfactory because of their side effects, such as sweating, nausea, runny nose and diarrhea. Read More

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http://dx.doi.org/10.1111/pin.12947DOI Listing

miR-744-5p contributes to ocular inflammation in patients with primary Sjogrens Syndrome.

Sci Rep 2020 May 4;10(1):7484. Epub 2020 May 4.

Department of Ophthalmology, Royal College of Surgeons in Ireland, Dublin 2, Ireland.

In primary Sjögren's syndrome (pSS) the exocrine glands become infiltrated with lymphocytes instigating severe damage to the salivary and lacrimal glands causing dry eyes and dry mouth. Previous investigations have suggested that dysregulated localized and systemic inflammation contributes to the development and pathogenesis of pSS. A miR microarray performed in primary human conjunctival epithelial cells (PECs) demonstrated significant differences in miR expression at the ocular surface between pSS patients and healthy controls. Read More

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http://dx.doi.org/10.1038/s41598-020-64422-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198540PMC

Clinical Characteristics of Secondary Immune Thrombocytopenia Associated With Primary Sjögren's Syndrome.

Front Med (Lausanne) 2020 17;7:138. Epub 2020 Apr 17.

Department of Rheumatology and Clinical Immunology, The First Affiliated Hospital of Xiamen University, Xiamen, China.

Clinical characteristics of immune thrombocytopenia (ITP) associated with primary Sjögren's syndrome (pSS) have not been clearly defined. This study aimed to evaluate the prevalence and clinical characteristics of secondary ITP in patients with pSS. 291 pSS patients in our hospital were retrospectively analyzed. Read More

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http://dx.doi.org/10.3389/fmed.2020.00138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181055PMC

The assessment of patients with the antiphospholipid antibody syndrome: where are we now?

Rheumatology (Oxford) 2020 May 1. Epub 2020 May 1.

Department of Rheumatology, University College London Hospitals NHS Foundation Trust, London, UK.

The antiphospholipid antibody syndrome (APS), a chronic autoimmune thrombophilia with an increased mortality and morbidity, has been recognized for more than three decades. Unlike other autoimmune rheumatic conditions such as systemic lupus erythematosus, myositis and Sjögren's syndrome, relatively few attempts have been made to develop activity, damage or disease-specific quality of life indices for APS. In this review of the literature, we consider those attempts that have been made to develop assessment tools for patients with APS, but also reflect upon the nature of the condition, to discuss, in particular, whether an activity index is appropriate for this disease. Read More

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http://dx.doi.org/10.1093/rheumatology/keaa172DOI Listing

Clinical significance of progranulin correlated with serum soluble Oxford 40 ligand in primary Sjögren's syndrome.

Medicine (Baltimore) 2020 May;99(18):e19967

Department of Rheumatism and Immunology, The Second Hospital of Hebei Medical University, Shijiazhuang, P.R. China.

The present study aimed to investigate the association between the expressions of serum progranulin (PGRN) and serum soluble Oxford 40 ligand (sOX40L) and determine their clinical significances in primary Sjögren's syndrome (pSS).The present study included a total of 68 patients with pSS and 50 healthy controls. Demographic data and clinical basic information were collected. Read More

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http://dx.doi.org/10.1097/MD.0000000000019967DOI Listing

Are Salivary Gland Ultrasonography Scores Associated with Salivary Flow Rates and Oral Health Related Quality of Life in Sjögren's syndrome?

J Rheumatol 2020 May 1. Epub 2020 May 1.

From the Division of Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey; Department of Health Management, Marmara University School of Health Sciences, Istanbul, Turkey; Division of Immunology, Marmara University, School of Medicine, Istanbul, Turkey; Marmara University, School of Medicine, Istanbul, Turkey; Department of Rheumatology, MC Groep Hospitals, Leystad, Netherlands. Address correspondence to Dr.Nevsun Inanc Division of Rheumatology, Department of Internal Medicine, School of Medicine, Marmara University, Istanbul, Turkey e-mail:

Objective: Ultrasonography of major salivary glands (SGUS) is a widely used imaging technique to evaluate salivary gland involvement in primary Sjögren's syndrome (pSS). The aim of this study was to evaluate the relationship between SGUS, salivary flow rate (SFR) as an objective measure of the gland function and oral health-related quality of life (OHRQoL) as a patientreported outcome measure (PROM) in a pSS cohort.

Methods: Sixty-six patients with pSS were examined by SGUS according to Hocevar and Milic scoring systems. Read More

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http://dx.doi.org/10.3899/jrheum.190849DOI Listing

Ocular manifestations in rheumatoid arthritis, connective tissue disease and vasculitis: a systematic review and meta-analysis.

J Rheumatol 2020 May 1. Epub 2020 May 1.

From the Schulich School of Medicine, University of Western Ontario, St. Joseph's Health Care, London, Ontario, Canada; University of Toronto, Toronto, Ontario, Canada; Canadian Rheumatology Association Research studentship, University of Western Ontario. This funding was supported through the Canadian Rheumatology Association Roche summer studentship. There are no conflicts of interest. IRB was not necessary as this was a systematic literature review. Address correspondence to Dr. Janet Pope MD MPH FRCPC, Division of Rheumatology, St. Joseph's Health Care, 268 Grosvenor St. London ON N6A 4V2,

Objective: Rheumatoid Arthritis and other rheumatic diseases may present with ocular manifestations. The purpose of our work was to determine the prevalence and type of eye involvement in rheumatoid arthritis and other connective tissue diseases through a meta-analysis and literature review.

Methods: A systematic review of the literature was performed using Medline, Web of Science, and the Cochrane library from their inceptions until January 7, 2019. Read More

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http://dx.doi.org/10.3899/jrheum.190768DOI Listing

Overlapping Sjogren's syndrome reduces the probability of reaching target in rheumatoid arthritis patients: a propensity score matched real-world cohort from 2009 to 2019.

Arthritis Res Ther 2020 May 1;22(1):100. Epub 2020 May 1.

Rheumatology and Clinical Immunology Department, Peking University First Hospital, Beijing, 100034, China.

Background: Overlapping Sjogren's syndrome (SS) is not uncommon in rheumatoid arthritis (RA) and considered as a probable detrimental factor of RA. But data on the impact of overlapping SS on RA therapeutic response is limited. Our current study aimed to identify the effect in a real-world cohort from 2009 to 2019. Read More

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http://dx.doi.org/10.1186/s13075-020-02189-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7195774PMC

Atypical clinical presentation of distal renal tubular acidosis: a case report registered in Amazonas, Brazil.

J Bras Nefrol 2020 Apr 27. Epub 2020 Apr 27.

Universidade Federal do Amazonas, Hospital Universitário Getúlio Vargas, Manaus, AM, Brasil.

We report an unusual case of a 24-year-old girl with a history of recurrent hypokalemic paralysis episodes and skin lesions on the lower limbs and buttocks, both of which had an acute evolution. In subsequent investigations, the patient also had nephrocalcinosis, nephrolithiasis, hyperchloremic metabolic acidosis and persistent alkaline urinary pH. The findings were consistent with distal renal tubular acidosis as the cause of hypokalemic paralysis. Read More

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http://dx.doi.org/10.1590/2175-8239-JBN-2019-0224DOI Listing

Clinical Features of Type B Insulin Resistance in Japanese Patients: Case Report and Survey-Based Case Series Study.

J Diabetes Res 2020 4;2020:4359787. Epub 2020 Apr 4.

Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan.

Type B insulin resistance (TBIR) is an extremely rare disease characterized by marked hyperglycemia and insulin resistance and often coexists with autoimmune diseases. The characteristics, symptoms, blood glucose patterns, comorbidities, and treatments of TBIR all vary and are not defined. In this study, we described a case of TBIR that developed 6 months after DPP-4 inhibitor administration and immediately after the patient caught a cold. Read More

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http://dx.doi.org/10.1155/2020/4359787DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7166280PMC

Disseminated histoplasmosis in primary Sjögren syndrome: A case report.

World J Clin Cases 2020 Apr;8(7):1319-1325

Department of Neurology, First Hospital of Jilin University, Changchun 130021, Jilin Province, China.

Background: Sjögren syndrome (SS) is a chronic and systemic autoimmune disease characterized by lymphocytic infiltration of the exocrine glands. And histoplasmosis is an invasive mycosis caused by the saprophytic dimorphic fungus . In patients with primary SS (PSS), disseminated histoplasmosis (DH) is extremely rare. Read More

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http://dx.doi.org/10.12998/wjcc.v8.i7.1319DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176620PMC

Constrictive (Obliterative) Bronchiolitis as Presenting Manifestation of Connective Tissue Diseases.

J Clin Rheumatol 2020 Apr 23. Epub 2020 Apr 23.

Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN.

Background: Constrictive (obliterative) bronchiolitis (CB) is an uncommon form of obstructive lung disease that can occur in patients with identifiable causes including connective tissue diseases (CTDs) as a form of lung involvement. We explored whether CB can be the presenting manifestation of CTD.

Methods: We retrospectively identified 44 patients with cryptogenic CB and examined the presenting clinical, laboratory, and radiologic features, as well as their clinical course. Read More

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http://dx.doi.org/10.1097/RHU.0000000000001387DOI Listing