Salivary epidermal growth factor concentrations in patients with Sjögren syndrome and laryngopharyngeal reflux.
- Claudia A Eckley,
- Marco Antônio Dos Anjos Corvo,
- Luis Roberto Sardinha,
- Bianca Liquidato,
- Luiz Vicente Rizzo
Ear Nose Throat J 2017 Jun;96(6):E6-E11
Department of Otolaryngology, Santa Casa School of Medicine and Hospitals, Av. Vereador José Diniz 3457, cj 501, São Paulo, Brazil.
Sjögren syndrome was chosen as a clinical model to study acinar salivary deficiencies in the development of laryngopharyngeal reflux (LPR). The objective of this prospective cohort study was to compare salivary epidermal growth factor (EGF) concentrations of patients with Sjögren syndrome with and without LPR and gastroesophageal reflux disease (GERD) with normal controls. LPR was diagnosed with positive scores on the Reflux Symptom Index and Reflux and Reflux Finding Score, corroborated by esophagogastroduodenoscopy and/or 24-hour pH-metry. Read More