16,870 results match your criteria Sjogren Syndrome


Assessment and outcome of AV conduction in normal and anti-Ro/SSA antibody positive pregnancies evaluated by echocardiography and magnetocardiography.

Ultrasound Obstet Gynecol 2019 Feb 19. Epub 2019 Feb 19.

Department of Medical Physics, The University of Wisconsin, Madison, WI.

Objectives: 1. Evaluate the association between echocardiographic AV and magnetocardiographic PR intervals at different gestational ages. 2. Read More

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http://dx.doi.org/10.1002/uog.20245DOI Listing
February 2019

Amyloid tumor of the breast.

Surg Case Rep 2019 Feb 19;5(1):31. Epub 2019 Feb 19.

Department of Breast Oncology, Aichi Cancer Center, 1-1 Kanokoden, Chikusa-ku, Nagoya, 464-8681, Japan.

Background: Amyloid tumor of the breast is a rare disease, which was first reported in 1973. To date, only six cases have been reported in Japan.

Case Presentation: A 45-year-old woman who had a medical history of Sjogren's syndrome presented with a lump of 3 cm in diameter on the outer side of the right breast. Read More

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http://dx.doi.org/10.1186/s40792-019-0591-zDOI Listing
February 2019

[Schirmer test for determining the moisture status of the nasal mucosa].

HNO 2019 Feb 19. Epub 2019 Feb 19.

Klinik für Hals‑, Nasen- und Ohrenheilkunde, Universitätsklinikum Ulm, Frauensteige 12, 89075, Ulm, Deutschland.

Background: There is no established method to objectively measure the moisture status of nasal mucosa. In a pilot study it was shown that a nasal Schirmer test is a possible method. The aim of the current study was to check whether the nasal Schirmer test is suitable to define moisture status in cases with an expected pathological secretion. Read More

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http://dx.doi.org/10.1007/s00106-019-0627-5DOI Listing
February 2019

Thermophoretic diagnosis of autoimmune diseases based on Escherichia coli with autodisplayed autoantigens.

Anal Chim Acta 2019 May 21;1055:106-114. Epub 2018 Dec 21.

Department of Materials Science and Engineering, Yonsei University, 134 Shinchon-dong, Seodaemun-gu, Seoul, 120-749, South Korea. Electronic address:

The autoimmune diseases systemic lupus erythematosus (SLE) and Sjogren's syndrome (SS) are diagnosed by detection of autoantibodies against Ro and La protein autoantigens, respectively. In this work, the diagnosis of autoimmune diseases SLE and SS was demonstrated using thermophoresis of Escherichia coli with the autodisplayed autoantigens. Ro and La protein autoantigens were autodisplayed by constitutive expression together with a fluorescent protein called tdTomato in the cytosol. Read More

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http://dx.doi.org/10.1016/j.aca.2018.12.038DOI Listing

Corticosteroid dose increase is a risk factor for nonalcoholic fatty liver disease and contralateral osteonecrosis of the femoral head: a case report.

BMC Musculoskelet Disord 2019 Feb 19;20(1):88. Epub 2019 Feb 19.

Department of Orthopaedic Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Kita-15 Nishi-7, Kita-ku, Sapporo, 060-8638, Japan.

Background: The incidence of bilateral corticosteroid-induced osteonecrosis of the femoral head (ONFH) is high. Although the precise mechanism of corticosteroid-induced ONFH development is unclear, hepatic enzyme abnormalities such as low activity of hepatic cytochrome P450 3A could be one cause. Herein, we report the case of a patient who developed ONFH in the contralateral hip after the dose of corticosteroids for idiopathic thrombocytopenic purpura was increased. Read More

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http://dx.doi.org/10.1186/s12891-019-2468-5DOI Listing
February 2019

The role of microRNA-16 in the pathogenesis of autoimmune diseases: A comprehensive review.

Biomed Pharmacother 2019 Feb 16;112:108583. Epub 2019 Feb 16.

Third-Grade Pharmacological Laboratory on Chinese Medicine Approved by State Administration of Traditional Chinese Medicine, Medical College of China Three Gorges University, Yichang, Hubei, 443002, China. Electronic address:

MicroRNAs (miRNAs) are a class of small noncoding RNAs that are only 21-25 nt long. Many studies have shown that miRNA dysfunction is closely related to the occurrence and development of diseases. By combining with the 3' noncoding region of target gene mRNA, miRNAs can mediate the degradation or translation inhibition of mRNA and exert a powerful regulation effect on gene expression at the posttranscriptional level, mainly inhibiting the translation or degradation of targets. Read More

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http://dx.doi.org/10.1016/j.biopha.2019.01.044DOI Listing
February 2019

Two subgroups in systemic lupus erythematosus with features of antiphospholipid or Sjögren's syndrome differ in molecular signatures and treatment perspectives.

Arthritis Res Ther 2019 Feb 18;21(1):62. Epub 2019 Feb 18.

Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, 171 76, Stockholm, Sweden.

Background: Previous studies and own clinical observations of patients with systemic lupus erythematosus (SLE) suggest that SLE harbors distinct immunophenotypes. This heterogeneity might result in differences in response to treatment in different subgroups and obstruct clinical trials. Our aim was to understand how SLE subgroups may differ regarding underlying pathophysiology and characteristic biomarkers. Read More

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http://dx.doi.org/10.1186/s13075-019-1836-8DOI Listing
February 2019

The cumulative incidence and trends of rare diseases in South Korea: a nationwide study of the administrative data from the National Health Insurance Service database from 2011-2015.

Orphanet J Rare Dis 2019 Feb 18;14(1):49. Epub 2019 Feb 18.

The Institute for Occupational Health, Yonsei University College of Medicine, Seoul, Republic of Korea.

Background: The burden of rare diseases on society and patients' families has increased in Korea. However, because of the infrequency of rare diseases, there is a lack of resources and information to address these cases and inadequate funding for the management of these patients. We investigated the average annual cumulative incidence of rare diseases and the trends in annual cumulative incidence from 2011 to 2015 in Korea by using nationwide administrative data from the Korean National Health Insurance Service (NHIS) database for patients registered with the co-payment assistance policy for rare and incurable diseases. Read More

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https://ojrd.biomedcentral.com/articles/10.1186/s13023-019-1
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http://dx.doi.org/10.1186/s13023-019-1032-6DOI Listing
February 2019
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Geoepidemiology of Sjögren's syndrome in Latin America.

Joint Bone Spine 2019 Feb 15. Epub 2019 Feb 15.

Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Bogota, Colombia. Electronic address:

Objective: To evaluate the geoepidemiology of Sjögren's syndrome (SS) in Latin America.

Methods: This was a three phase study in which original data from a Colombian cohort of patients with SS is presented, followed by a systematic review of Colombian and Latin American studies. Lastly, the geoepidemiology of SS in Latin America was assessed by comparing the clinical characteristics of the region with those of the rest of the world by means of a meta-analysis approach. Read More

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http://dx.doi.org/10.1016/j.jbspin.2019.02.004DOI Listing
February 2019
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Danger signals in oral cavity-related diseases.

J Leukoc Biol 2019 Feb 18. Epub 2019 Feb 18.

Department of Oral Biology, School of Dental Medicine, University at Buffalo, Buffalo, New York, USA.

The oral cavity is a unique environment containing teeth juxtaposed with soft tissues, all of which are constantly bathed in microbial products and host-derived factors. While microbial dysbiosis in the oral cavity clearly leads to oral inflammatory disease, recent advances find that endogenous danger-associated molecular patterns (DAMPs) released from oral and salivary tissue also contribute to the progression of inflammatory and autoimmune disease, respectively. In contrast, DAMPs produced during oral fungal infection actually promote the resolution of infection. Read More

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http://dx.doi.org/10.1002/JLB.4MIR1118-439RDOI Listing
February 2019

Sjögren's syndrome and systemic lupus erythematosus: links and risks.

Open Access Rheumatol 2019 29;11:33-45. Epub 2019 Jan 29.

Rheumatology Division, Hospital das Clinicas, Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Sao Paulo, Brazil,

Systemic lupus erythematosus (SLE) and Sjögren's syndrome (SS) may coexist, and they are chronic complex disorders, with an autoimmune background, multifactorial etiology, multiple circulating autoantibodies, and variable prognosis. The prominent feature of SS is the impairment of the lacrimal and salivary glands leading to sicca symptoms. This disease may be classified as primary Sjögren's syndrome (pSS), or secondary Sjögren's syndrome (sSS) since it is often associated to other autoimmune disorders, principally SLE, rheumatoid arthritis, and systemic sclerosis. Read More

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http://dx.doi.org/10.2147/OARRR.S167783DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357904PMC
January 2019

[Clinicopathological features and possible prognostic factors in parotid lymphomas].

Beijing Da Xue Xue Bao Yi Xue Ban 2019 Feb;51(1):35-42

Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China.

Objective: To investigate the clinicopathological features and prognostic factors in lymphoma of parotid origin.

Methods: Clinicopathological data of the patients with parotid lymphoma who were initially diagnosed in Peking University Hospital of Stomatology from 2006 to 2016 were collected and analyzed retrospectively. The patients were followed-up for 5 to 149 months with a median period of 45 months, and the factors influencing the prognosis were evaluated. Read More

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http://dx.doi.org/10.19723/j.issn.1671-167X.2019.01.007DOI Listing
February 2019

[Clinicopathological characteristics and diagnosis of IgG4related sialadenitis].

Beijing Da Xue Xue Bao Yi Xue Ban 2019 Feb;51(1):1-3

Department of Oral Radiology, Peking University School and Hospital of Stomatology, Beijing 100081, China.

Immunoglobulin G4-related sialadenitis (IgG4-RS) is a newly recognized immune-mediated disease and one of immunoglobulin G4-related diseases (IgG4-RD). Our multidisciplinary research group investigated the clinicopathological characteristics and diagnosis of IgG4-RS during the past 10 years. Clinically, it showed multiple bilateral enlargement of major salivary glands (including sublingual and accessory parotid glands) and lacrimal glands. Read More

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http://dx.doi.org/10.19723/j.issn.1671-167X.2019.01.001DOI Listing
February 2019
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Clinical significance and immunobiology of IL-21 in autoimmunity.

J Autoimmun 2019 Feb 14. Epub 2019 Feb 14.

Department of Dermatology, Second Xiangya Hospital, Central South University, Hunan Key Laboratory of Medical Epigenomics, Changsha, Hunan, PR China. Electronic address:

Interleukin-21 (IL-21), an autocrine cytokine predominantly produced by follicular helper T (Tfh) and T helper 17 (Th17) cells, has been proven to play an important role in the immune system, for example, by promoting proliferation and the development of Tfh and Th17 cells, balancing helper T cell subsets, inducing B cell generation and differentiation into plasma cells, and enhancing the production of immunoglobulin. These effects are mainly mediated by activation of the JAK/STAT, MAPK and PI3K pathways. Some IL-21 target genes, such as B lymphocyte induced maturation protein-1 (Blimp-1), suppressor of cytokine signaling (SOCS), CXCR5 and Bcl-6, play important roles in the immune response. Read More

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http://dx.doi.org/10.1016/j.jaut.2019.01.013DOI Listing
February 2019
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Juvenile polyautoimmunity in a rheumatology setting.

Autoimmun Rev 2019 Feb 14. Epub 2019 Feb 14.

Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Bogota, Colombia.. Electronic address:

Overt polyautoimmunity (PolyA) corresponds to the presence of more than one well-defined autoimmune disease (AD) manifested clinically in a single patient. The current study aimed to describe the main characteristics of juvenile PolyA in a pediatric rheumatology setting and analyze the chronological aspects, index cases, familial autoimmunity, and clustering pattern. This was a cross-sectional and multicenter study in which 313 children with overt PolyA were included. Read More

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http://dx.doi.org/10.1016/j.autrev.2018.11.006DOI Listing
February 2019
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Genetics and epigenetics in primary Sjögren's syndrome.

Rheumatology (Oxford) 2019 Feb 15. Epub 2019 Feb 15.

Department of Medical Sciences, Rheumatology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.

Primary Sjögren's syndrome (pSS) is considered to be a multifactorial disease, where underlying genetic predisposition, epigenetic mechanisms and environmental factors contribute to disease development. In the last 5 years, the first genome-wide association studies in pSS have been completed. The strongest signal of association lies within the HLA genes, whereas the non-HLA genes IRF5 and STAT4 show consistent associations in multiple ethnicities but with a smaller effect size. Read More

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http://dx.doi.org/10.1093/rheumatology/key330DOI Listing
February 2019

T cells in primary Sjögren's syndrome: targets for early intervention.

Rheumatology (Oxford) 2019 Feb 15. Epub 2019 Feb 15.

Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

A histologic hallmark of primary SS (pSS) is lymphocytic infiltration of the salivary and lacrimal glands, in particular by CD4+ T and B cells. In the early stages of the disease, infiltrates are dominated by CD4+ T cells, while B cell accumulation occurs at later stages. Activated T cells contribute to pathogenesis by producing pro-inflammatory cytokines and by inducing B cell activation, which results in the establishment of a positive feedback loop. Read More

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http://dx.doi.org/10.1093/rheumatology/kez004DOI Listing
February 2019

Health-related quality of life and costs in Sjögren's syndrome.

Rheumatology (Oxford) 2019 Feb 15. Epub 2019 Feb 15.

National Institute for Health Research (NIHR) Birmingham Biomedical Research Centre, University of Birmingham, Birmingham, UK.

Health-related quality of life (HRQoL) has an increasing role in medical decision-making. This review of the literature aims to provide an overview on HRQoL, costs, and work disability in SS, a disease characterized by focal lymphocytic infiltration of exocrine glands with no therapeutics of proven immunomodulatory potential. HRQoL is markedly reduced in SS in multiple studies across many countries when compared with HRQoL in healthy controls. Read More

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http://dx.doi.org/10.1093/rheumatology/key370DOI Listing
February 2019
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How to treat Sjögren's syndrome.

Rheumatology (Oxford) 2019 Feb 15. Epub 2019 Feb 15.

Division of Rheumatology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

SS is a chronic, autoimmune disease of unknown aetiology for which there is no known curative treatment. Although dryness of the eyes and mouth are the classically described features, patients often experience drying of other mucosal surfaces and systemic manifestations, including fatigue and arthralgia. There is an association with other autoimmune diseases, especially thyroid disease, coeliac disease and primary biliary cholangitis. Read More

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http://dx.doi.org/10.1093/rheumatology/key363DOI Listing
February 2019

B cells in Sjögren's syndrome: from pathophysiology to therapeutic target.

Rheumatology (Oxford) 2019 Feb 15. Epub 2019 Feb 15.

UMR1227, Lymphocytes B et Autoimmunité, Université de Brest, Inserm, France.

Biological abnormalities associated with B lymphocytes are a hallmark of patients with primary Sjögren's syndrome. Those patients present abnormal distribution of B lymphocytes in peripheral blood and B cells in exocrine glands. B cells produce auto-antibodies, cytokines and present antigens but can also suppressive functions. Read More

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http://dx.doi.org/10.1093/rheumatology/key332DOI Listing
February 2019

Health-related quality of life in systemic sclerosis compared with other rheumatic diseases: a cross-sectional study.

Arthritis Res Ther 2019 Feb 15;21(1):61. Epub 2019 Feb 15.

Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, 03080, Republic of Korea.

Background: Systemic sclerosis (SSc) is a rare autoimmune disease characterized by fibrosis of the skin and the involvement of multiple internal organs. Previous studies reported poorer health-related quality of life (HRQoL) in patients with SSc compared with the general population. However, very little is known about how HRQoL in SSc patients compares with that in patients with other systemic autoimmune diseases, such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and Sjogren's syndrome (SjS). Read More

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http://dx.doi.org/10.1186/s13075-019-1842-xDOI Listing
February 2019
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Comorbidities (excluding lymphoma) in Sjögren's syndrome.

Rheumatology (Oxford) 2019 Feb 15. Epub 2019 Feb 15.

Rheumatology Department, Doctor Negrín University Hospital of Gran Canaria, Gran Canaria, Spain.

The information about comorbidities (excluding lymphoma) in primary Sjögren's syndrome (pSS) is relatively scarce. Cardiovascular disease, infections, musculoskeletal conditions or malignancy are likely the most relevant comorbid conditions in pSS. Different infections (particularly oral candidal infections) and fibromyalgia are extremely frequent in the daily clinical practice. Read More

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http://dx.doi.org/10.1093/rheumatology/key329DOI Listing
February 2019
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Innate immunity and interferons in the pathogenesis of Sjögren's syndrome.

Rheumatology (Oxford) 2019 Feb 15. Epub 2019 Feb 15.

Department of Medicine, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

Primary SS (pSS) is a rheumatic disease characterized by an immune-mediated exocrinopathy, resulting in severe dryness of eyes and mouth. Systemic symptoms include fatigue and joint pain and a subset of patients develop more severe disease with multi-organ involvement. Accumulating evidence points to involvement of innate immunity and aberrant activity of the type I IFN system in both the initiation and propagation of this disease. Read More

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http://dx.doi.org/10.1093/rheumatology/key360DOI Listing
February 2019

Comparison of Sensitivities of American College of Rheumatology and Systemic Lupus International Collaborating Clinics Classification Criteria in Childhood-onset Systemic Lupus Erythematosus.

J Rheumatol 2019 Feb 15. Epub 2019 Feb 15.

From the Division of Rheumatology, The Hospital for Sick Children; Faculty of Medicine, University of Toronto; Translational Medicine, SickKids Research Institute, Toronto, Ontario, Canada. J.J. Tao, BSc, Division of Rheumatology, The Hospital for Sick Children, and Faculty of Medicine, University of Toronto, and Translational Medicine, SickKids Research Institute; L.T. Hiraki, MD, FRCPC, ScD, Division of Rheumatology, The Hospital for Sick Children, and Faculty of Medicine, University of Toronto, and Translational Medicine, SickKids Research Institute; D.M. Levy, MD, FRCPC, Division of Rheumatology, The Hospital for Sick Children, and Faculty of Medicine, University of Toronto, and Translational Medicine, SickKids Research Institute; E.D. Silverman, MD, FRCPC, Division of Rheumatology, The Hospital for Sick Children, and Faculty of Medicine, University of Toronto, and Translational Medicine, SickKids Research Institute. Address correspondence to Dr. E.D. Silverman, The Hospital for Sick Children, 555 University Ave., Toronto, Ontario M5G 1X8, Canada. E-mail: Accepted for publication October 4, 2018.

Objective: Currently there are 2 different classification criteria for systemic lupus erythematosus (SLE): American College of Rheumatology (ACR) and Systemic Lupus International Collaborating Clinics (SLICC). The aim of this study was to compare the sensitivities of ACR and SLICC criteria in childhood-onset SLE (cSLE) using a large, multiethnic cohort.

Methods: We conducted a retrospective study of 722 patients diagnosed with cSLE at The Hospital for Sick Children (SickKids). Read More

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http://dx.doi.org/10.3899/jrheum.180337DOI Listing
February 2019
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Clinical Correlations of Novel Autoantibodies in Patients with Dry Eye.

J Immunol Res 2019 13;2019:7935451. Epub 2019 Jan 13.

Ocular Surface Diseases and Dry Eye Clinic, The Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland, USA.

Background: Diagnostic criteria for Sjögren's syndrome (SS) are continually being updated in pursuit of more precise and earlier diagnosis to prevent its complications. Owing to the high rate of false negative traditional serological markers, the need for better serological testing remains.

Objective: To investigate the clinical significance of three recently discovered novel autoantibodies, anti-salivary gland protein 1 (SP1), anti-carbonic anhydrase 6 (CA6), and anti-parotid secretory protein (PSP), in a cohort of dry eye patients with suspected underlying inflammatory/autoimmune disease. Read More

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http://dx.doi.org/10.1155/2019/7935451DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350592PMC
January 2019

Association between B Cell Growth Factors and Primary Sjögren's Syndrome-Related Autoantibodies in Patients with Non-Hodgkin's Lymphoma.

J Immunol Res 2019 13;2019:7627384. Epub 2019 Jan 13.

Department of Gastrointestinal Surgery, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430030, China.

Despite the overall success of using R-CHOP for the care for non-Hodgkin's lymphoma patients, it is clear that the disease is quite complex and new insight is needed to further stratify the patient for a better personized treatment. In current study, based on previous studies from animal model, new panels combining well-established cytokine (BAFF) and autoantibodies (anti-SSA/Ro) with newly identified cytokine (IL14) and autoantibodies (TSA) were used to evaluate the association between B cell growth factor and Sjögren's related autoantibodies in NHL patients. The result clearly indicates that there was a unique difference between BAFF and IL14 in association with autoantibodies. Read More

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http://dx.doi.org/10.1155/2019/7627384DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350562PMC
January 2019
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Misleading Diagnosis of Idiopathic Pulmonary Fibrosis: A Clinical Concern.

Fed Pract 2018 Feb;35(2):40-42

and are Pulmonary and Critical Care Medicine Fellow Physicians; and are Pulmonary and Critical Care Medicine Attending Physicians; and is a Research Study Coordinator, all at the VA Caribbean Healthcare System in San Juan, Puerto Rico.

Diagnosis of Sjogren syndrome should be based on consideration of the clinical presentation, a pulmonary function test, blood and rheumatology laboratory findings, radiographic imaging patterns, and biopsy results. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6248220PMC
February 2018
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Increased risk of bisphosphonate-related osteonecrosis of the jaw in patients with Sjögren's syndrome: nationwide population-based cohort study.

BMJ Open 2019 Feb 13;9(2):e024655. Epub 2019 Feb 13.

Department of Emergency Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.

Objective: The aim of this study was to explore whether patients with Sjögren's syndrome (SS) were susceptible to bisphosphonate (BP)-related osteonecrosis of the jaw (BRONJ) after tooth extraction in the entire population of Taiwan.

Design: A nationwide population-based retrospective cohort study.

Setting: Data were extracted from Taiwan's National Health Insurance Research Database (NHIRD). Read More

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http://dx.doi.org/10.1136/bmjopen-2018-024655DOI Listing
February 2019
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Bisphosphonate-induced orbital inflammation in a patient on chronic immunosuppressive therapy.

BMC Ophthalmol 2019 Feb 14;19(1):51. Epub 2019 Feb 14.

Department of Ophthalmology, University of Kansas School of Medicine, 7400 State Line Rd, Prairie Village, Kansas, USA.

Background: To report a case of orbital inflammation after bisphosphonate infusion in a patient who was already receiving immunosuppressive therapy.

Case Presentation: A 56-year-old woman presented to the ophthalmology clinic with acute onset of right eye pain 24 h after receiving her first Zolendronic acid infusion. She has a past medical history of chronic inflammatory demyelinating polyneuropathy, Sjogren's syndrome, and systemic lupus erythematosus that have been controlled with immunosuppressive therapy for three years. Read More

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http://dx.doi.org/10.1186/s12886-019-1063-8DOI Listing
February 2019
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Assessment of major salivary gland size in primary Sjögren's syndrome: comparison between clinical examination and ultrasonography.

Joint Bone Spine 2019 Feb 11. Epub 2019 Feb 11.

Service de rhumatologie, Centre National de Référence des Maladies Auto-immunes Rares de l'Adulte CERAINO, CHU de Brest, Brest, France; UMR1227, Lymphocytes B et Autoimmunité, Université de Brest, Inserm, LabEx IGO, Brest, France.

Objective: Parotidomegaly is a criterion of the EULAR Primary Sjögren Syndrome Disease Activity Index (ESSDAI). The cut-off value was set at 3 cm in length for the parotid gland, 2 cm for the submandibular glands. However, clinical appreciation of salivary glands size remains hazardous. Read More

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http://dx.doi.org/10.1016/j.jbspin.2019.01.025DOI Listing
February 2019

Increased GITRL Impairs the Function of Myeloid-Derived Suppressor Cells and Exacerbates Primary Sjögren Syndrome.

J Immunol 2019 Feb 13. Epub 2019 Feb 13.

Department of Laboratory Medicine, Affiliated People's Hospital, Jiangsu University, Zhenjiang 212002, China;

Although the expansion of myeloid-derived suppressor cells (MDSCs) has been reported in autoimmune disorders, it is largely unclear how MDSCs contribute to the development of primary Sjögren syndrome (pSS). In this study, we found significantly increased MDSCs with gradually diminished suppressive capacity during disease development in mice with experimental Sjögren syndrome (ESS). The ligand for glucocorticoid-induced TNFR family-related protein (GITRL) was increased along ESS progression, whereas the increased GITRL was found to attenuate the immunosuppressive function of MDSCs. Read More

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http://dx.doi.org/10.4049/jimmunol.1801051DOI Listing
February 2019

MIST1, an Inductive Signal for Salivary Amylase in Mesenchymal Stem Cells.

Int J Mol Sci 2019 Feb 12;20(3). Epub 2019 Feb 12.

Oral and Maxillofacial Diagnostic Sciences, University of Florida College of Dentistry, Gainesville, FL 32610, USA.

Sjögren's syndrome (SjS) is an autoimmune disease that destroys the salivary glands and results in severe dry mouth. Mesenchymal stem cell (MSC) transplantation has been recently proposed as a promising therapy for restoring cells in multiple degenerative diseases. We have recently utilized advanced proteomics biochemical assays to identify the key molecules involved in the mesenchymal-epithelial transition (MET) of co-cultured mouse bone-marrow-derived MSCs mMSCs with primary salivary gland cells. Read More

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http://dx.doi.org/10.3390/ijms20030767DOI Listing
February 2019
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Catatonia and Psychosis as Manifestations of Primary Sjögren's Syndrome.

Eur J Case Rep Intern Med 2018 26;5(6):000855. Epub 2018 Jun 26.

Consultant in Internal Medicine - Beatriz Ângelo Hospital, Loures, Portugal.

Primary Sjögren's syndrome (SS) is a chronic, systemic autoimmune disease, most commonly presenting with sicca symptoms-xerostomia and xerophthalmia. Up to one-half of affected individuals also develop extra-glandular involvement. Early diagnosis is important to prevent further complications. Read More

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http://dx.doi.org/10.12890/2018_000855DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346881PMC

Kikuchi-Fujimoto Disease Associated with Sjögren's Syndrome: A Case Report.

Eur J Case Rep Intern Med 2018 25;5(5):000856. Epub 2018 May 25.

Rheumatology Department, Hamad Medical Corporation, Doha, Qatar.

Kikuchi-Fujimoto disease (KFD) or Kikuchi histiocytic necrotizing lymphadenitis, is an extremely rare, benign and self-limiting disease which can be confused with lymphoma and sometime with infections such as tuberculosis. It has also been infrequently reported in association with autoimmune diseases. KFD shares sex and age predisposition as well as histological features with systemic lupus erythematosus. Read More

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http://dx.doi.org/10.12890/2018_000856DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346929PMC
May 2018
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Mesenteric Panniculitis in Sjögren's Syndrome: A New Systemic Manifestation to Consider?

Eur J Case Rep Intern Med 2018 24;5(4):000788. Epub 2018 Apr 24.

Department of Internal Medicine A, Coimbra Hospital and University Center, Coimbra, Portugal.

The association between mesenteric panniculitis and Sjögren's syndrome, although rare, is starting to be recognized. Usually, mesenteric panniculitis is symptomatic, presenting with either general or gastrointestinal symptoms. Sjögren's syndrome is an autoimmune disease that typically affects secretory glands, but may have serious systemic involvement. Read More

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http://dx.doi.org/10.12890/2018_000788DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346754PMC

Protocolised Odontological Assessment of Patients With Primary Sjögren's Syndrome.

Reumatol Clin 2019 Feb 8. Epub 2019 Feb 8.

Servicio de Reumatología, Hospital Universitario Infanta Sofía, San Sebastián de los Reyes, Madrid, España.

Objective: The aim of this study is to describe the findings of a protocolised odontological evaluation of patients with primary Sjögren's syndrome (pSS) treated in rheumatology units in the Community of Madrid.

Methods: Multicentric descriptive study in which pSS patients classified according to the American-European consensus of 2002 criteria were included. We collected the demographic, clinical and serological data of each patient. Read More

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http://dx.doi.org/10.1016/j.reuma.2018.12.005DOI Listing
February 2019

Cytokine Profiles in Autoantibody Defined Subgroups of Systemic Lupus Erythematosus.

J Proteome Res 2019 Feb 18. Epub 2019 Feb 18.

Computational Life Science Cluster (CLiC), Department of Chemistry , Umeå University , 901 87 Umeå , Sweden.

The aim of this study was to evaluate how the cytokine profiles differed between autoantibody based subgroups of systemic lupus erythematosus (SLE). SLE is a systemic autoimmune disease, characterized by periods of flares (active disease) and remission (inactive disease). The disease can affect many organ systems, e. Read More

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http://dx.doi.org/10.1021/acs.jproteome.8b00811DOI Listing
February 2019
2 Reads

Post-licensure surveillance of trivalent adjuvanted influenza vaccine (aIIV3; Fluad), Vaccine Adverse Event Reporting System (VAERS), United States, July 2016-June 2018.

Vaccine 2019 Mar 7;37(11):1516-1520. Epub 2019 Feb 7.

Immunization Safety Office, Division of Healthcare Quality Promotion, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, United States.

Background: Trivalent adjuvanted influenza vaccine (aIIV3; Fluad®) was approved in the United States (U.S.) in 2015 for adults aged ≥65 years and has been in use since the 2016-17 influenza season. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0264410X193012
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http://dx.doi.org/10.1016/j.vaccine.2019.01.052DOI Listing
March 2019
4 Reads

Can Sjögren's syndrome diagnosis and evaluation be stretched by elastography?

Int J Rheum Dis 2019 Feb;22(2):172-174

Department of Internal Medicine, Clinical Ultrasound and Training Services, Royal Adelaide Hospital, Adelaide, South Australia, Australia.

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http://dx.doi.org/10.1111/1756-185X.13492DOI Listing
February 2019
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The Risk of Sjogren's Syndrome in the Older adults with Gout: A Medicare Claims Study.

Joint Bone Spine 2019 Feb 6. Epub 2019 Feb 6.

Department of Medicine at the School of Medicine, University of Alabama at Birmingham, 1720 Second Ave. South, Birmingham, 35294-0022 AL, USA.

Objectives: In the absence of previous studies, our objective was to assess whether gout was associated with an increase or decrease in the risk of Sjogren's Syndrome (SS) in older adults, 65 years or older.

Methods: We used the 5% Medicare claims from 2006-2012. A multivariable Cox regression model assessed the association of gout with incident SS adjusting for age, sex, race, Charlson-Romano comorbidity index, and the use of medications for cardiovascular diseases (statins, beta-blockers, diuretics, ACE-inhibitors) and gout (allopurinol, febuxostat). Read More

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http://dx.doi.org/10.1016/j.jbspin.2019.01.022DOI Listing
February 2019
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A 45-Year-Old Woman With Multiple Pulmonary Nodules and Sjögren Syndrome.

Chest 2019 Feb;155(2):e51-e54

Divisions of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, University of Texas Health Science Center at Houston-McGovern Medical School, Houston, TX.

Case Presentation: A 45-year-old woman presented for evaluation for 3 months of coughing and dyspnea. A recent chest CT scan done for workup of her symptoms revealed a 2-cm right-sided pulmonary nodule. She had a medical history of Sjögren syndrome, hypertension, and obesity. Read More

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http://dx.doi.org/10.1016/j.chest.2018.08.1077DOI Listing
February 2019
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The association between vitamin D level and Sjögren's syndrome: A meta-analysis.

Int J Rheum Dis 2019 Feb 6. Epub 2019 Feb 6.

Department of Laboratory Medicine, West China Second University Hospital, Sichuan University, Chengdu, China.

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http://dx.doi.org/10.1111/1756-185X.13474DOI Listing
February 2019
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Increased antibody levels to stage-specific Epstein-Barr virus antigens in systemic autoimmune diseases reveal a common pathology.

Scand J Clin Lab Invest 2019 Feb 6:1-10. Epub 2019 Feb 6.

h Department of Autoimmunology and Biomarkers , Statens Serum Institut , Copenhagen , Denmark.

The immune responses to antigens from different stages of the Epstein-Barr virus (EBV) life cycle were investigated in systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), Sjögren's syndrome (SS), and systemic sclerosis (SSc) to gain knowledge of EBV's involvement in the etiology of systemic autoimmune diseases (SADs) and for an overview of the humoral immune responses against EBV. Investigations were performed by the use of ELISA. IgM, IgA, and IgG antibody binding to 11 EBV antigens: EBNA1, EBNA2, BALF5, EAD, BALF2, EA/R, VCA p18, VCA p23, gB, gp350, and gp42 were examined in serum pools from SAD patients and healthy controls (HCs). Read More

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http://dx.doi.org/10.1080/00365513.2018.1550807DOI Listing
February 2019
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Influence of Hormones on Sjögren's Syndrome.

Curr Pharm Des 2018 ;24(35):4167-4176

Department of Prosthodontics, Dental Hospital, Jilin University, Changchun, Jilin 130021, China.

Sjögren's syndrome (SS) is an immune system oral disorder that is characterized generally by dry mouth and eyes. In this review, SS classification, presentation and pathogenesis are briefly discussed. Moreover, the epidemiology of SS regarding sex, age and association with other complications are also presented. Read More

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http://dx.doi.org/10.2174/1381612824666181010153536DOI Listing
January 2018
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Microbial Agents as Putative Inducers of B Cell Lymphoma in Sjögren's Syndrome through an Impaired Epigenetic Control: The State-of-The-Art.

J Immunol Res 2019 6;2019:8567364. Epub 2019 Jan 6.

Rheumatology Unit, University of Messina, Messina, Italy.

Introduction: Understanding the mechanisms underlying the pathogenesis of Sjögren's syndrome (SS) is crucially important in order to be able to discriminate the steps that lead to B cell transformation and promptly identify the patients at risk of lymphomagenesis. The aim of this narrative review is to describe the evidence concerning the role that infections or dysbiosis plays in the epigenetic control of gene expression in SS patients and their possible involvement in B cell lymphomagenesis.

Materials And Methods: We searched the PubMed and Google Scholar databases and selected a total of 92 articles published during the last 25 years that describe experimental and clinical studies of the potential associations of microbiota and epigenetic aberrations with the risk of B cell lymphoma in SS patients. Read More

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http://dx.doi.org/10.1155/2019/8567364DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339763PMC
January 2019
2 Reads

Sjögren's Syndrome: Concerted Triggering of Sicca Conditions.

J Immunol Res 2019 6;2019:2075803. Epub 2019 Jan 6.

Department of Experimental, Clinical and Preventive Medicine, State Research Institute Centre for Innovative Medicine, Santariskiu St. 5, LT-08406 Vilnius, Lithuania.

Aim: The aim of this study was to evaluate the expression of persistence of mumps virus and some cells that interact with viral infection in the focus of the autoimmune epithelitis and peripheral blood of Sjögren's syndrome patients in comparison to patients with rheumatoid arthritis (RA) and nonautoimmune sicca syndrome (nSS).

Materials And Methods: 126 patients (119 women and 7 men) were grouped into four groups: (1) patients with primary Sjögren's syndrome (pSS), (2) patients with secondary Sjögren's syndrome due to rheumatoid arthritis (sSS), (3) patients with rheumatoid arthritis (RA), and (4) patients with nonautoimmune sicca syndrome (nSS). Immunohistochemical analysis of immune response to the suggested silent persistence of mumps virus in the minor labial salivary gland biopsies and flow cytometric analysis of blood cells was done. Read More

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http://dx.doi.org/10.1155/2019/2075803DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339734PMC
January 2019
3 Reads

Yield of Screening Tests for Systemic Vasculitis in Young Adults with Ischemic Stroke.

Eur Neurol 2019 Feb 4;80(5-6):245-248. Epub 2019 Feb 4.

Department of Neurology, Inha University School of Medicine, Incheon, Republic of

Systemic vasculitis, which can involve the brain, may be one of the causes of stroke in young adults; therefore, a test panel for systemic vasculitis is considered for some young stroke patients. However, little is known about this test's yield as a screening test in young adults with ischemic stroke. We evaluated the yield of a panel for systemic vasculitis as a screening test in young patients with ischemic stroke. Read More

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http://dx.doi.org/10.1159/000496373DOI Listing
February 2019
1 Read
1.362 Impact Factor

Salivary gland secretome: a novel tool towards molecular stratification of patients with primary Sjögren's syndrome and non-autoimmune sicca.

RMD Open 2019 11;5(1):e000772. Epub 2019 Jan 11.

Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.

Objective: To explore the potential of salivary gland biopsy supernatants (the secretome) as a novel tool to aid in stratification of patients with sicca syndrome and to study local immunopathology in Sjögren's syndrome.

Methods: Labial salivary gland biopsies were incubated in saline for 1 hour. In these tissue supernatants from a discovery cohort (n=16) of patients with primary Sjögren's syndrome (pSS) and non-Sjögren's sicca (nSS), 101 inflammatory mediators were measured by Luminex. Read More

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http://dx.doi.org/10.1136/rmdopen-2018-000772DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340539PMC
January 2019
1 Read