19,795 results match your criteria Sjogren Syndrome


Elevated CXCL13 in primary Sjögren's syndrome and its correlation with disease activity: a systematic review and meta-analysis.

Clin Rheumatol 2022 May 26. Epub 2022 May 26.

National Center for Birth Defect Monitoring, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, and State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, 610041, Sichuan, China.

Objectives: CXCL13 levels have been reported to be elevated in primary Sjögren's syndrome (pSS) patients. This study investigated alterations involving the CXCL13/CXCR5 axis in pSS patients and explored the correlation between CXCL13 expression and disease severity.

Methods: Six databases, including PubMed, Web of Science, Embase, Ovid Medline, China National Knowledge Infrastructure, and Wanfang, were searched. Read More

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Candidate autoantibodies for primary Sjögren's syndrome: where are they now?

Clin Exp Rheumatol 2022 May 26. Epub 2022 May 26.

Department of Immunology, Douglass Hanly Moir, Pathology, Sonic Health, Macquarie Park, Australia.

Although ANA, SSA and SSB antibody testing are universally accepted biomarkers for Sjögren's syndrome (SS) diagnosis, they do not occur in all patients. Up to 18% of SS patients are seronegative, with potential for delayed or missed diagnosis. There are no clinically available autoantibodies with predictive value for SS end-organ complications. Read More

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Exploring the risk factors and prognosis of transverse myelitis in systemic lupus erythematosus.

Ther Adv Chronic Dis 2022 19;13:20406223221097330. Epub 2022 May 19.

Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College.

Purpose: We aimed to describe the clinical characteristics and outcomes of patients with transverse myelitis (TM) as a rare manifestation in systemic lupus erythematosus (SLE) and explore the risk factors and prognosis of SLE-related TM (SLE-TM).

Methods: We conducted a retrospective case-control and cohort analysis. All patients with SLE-TM (58 patients) and 232 with SLE without TM, as a control group, were admitted to Peking Union Medical College Hospital between January 1993 and May 2021. Read More

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Prevalence of Sjögren's Syndrome in Patients with Dry Mouth in the Region of Central Hungary.

Oral Dis 2022 May 25. Epub 2022 May 25.

Semmelweis University, Faculty of Dentistry, Department of General Dental Preclinical Practice, Budapest.

Objective: One third of the Hungarian population suffers from xerostomia. Since there is no evidence on the actual prevalence of Sjögren's syndrome (SS) in Hungary, this study aimed to evaluate the same.

Materials And Methods: Data were collected from the Faculty of Dentistry, Semmelweis University from 2008 to 2015. Read More

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Clinical Phenotype and Mechanisms of Leukopenia/Neutropenia in Patients with Primary Sjögren's Syndrome.

Mediterr J Rheumatol 2022 Mar 31;33(1):99-101. Epub 2022 Mar 31.

Department of Pathophysiology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.

Sjögren's syndrome (SS) is a chronic, systemic autoimmune disease which afflicts mainly the exocrine salivary and lachrymal glands, leading to mouth and eye dryness. However, any organ can be affected during the disease course, resulting in a variety of clinical manifestations. Sjögren's syndrome clinical manifestations can be classified into glandular (sicca manifestations or parotid swelling), extra-glandular, either nonspecific (arthralgias, arthritis, Raynaud's phenomenon, fatigue) or peri-epithelial (primary biliary cirrhosis, interstitial nephritis, bronchiolitis), and extra-epithelial (palpable glomerulonephritis, peripheral neuropathy, purpura). Read More

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Vitamin D Deficiency in Primary Sjögren's Syndrome: Association with Clinical Manifestations and Immune Activation Markers.

Mediterr J Rheumatol 2022 Mar 31;33(1):106-108. Epub 2022 Mar 31.

Department of Physiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Vitamin D is an agent involved in bone and mineral homeostasis. It has been recognized as a potent immunomodulator. It has immune-enhancing properties, and it induces immune tolerance. Read More

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Reduced Tear Thrombospondin-1/Matrix Metalloproteinase-9 Ratio Can Aid in Detecting Sjögren's Syndrome Etiology in Patients with Dry Eye.

Clin Transl Sci 2022 May 24. Epub 2022 May 24.

Ocular Surface Diseases and Dry Eye Clinic, The Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Differentiating patients with Sjögren's syndrome (SS) associated dry eye from non-SS dry eye is critical for monitoring and appropriate management of possible sight- or life-threatening extraglandular complications associated with SS. We tested whether reduced tear levels of immunoregulatory thrombospondin (TSP)-1, which also inhibits matrix metalloproteinase (MMP)-9, would reflect SS pathogenesis aiding the identification of patients with SS-dry eye. Total of 61 participants, including healthy controls (n=20), patients with non-SS dry eye (n=20) and SS-dry eye (n=21) were enrolled prospectively. Read More

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Acute fibrinous and organizing pneumonia in a patient with Sjögren's syndrome and Legionella pneumonia: a case report and literature review.

BMC Pulm Med 2022 May 24;22(1):205. Epub 2022 May 24.

Department of Pulmonary and Critical Care Medicine, Shengjing Hospital of China Medical University, Shenyang, China.

Background: Acute fibrinous and organizing pneumonia (AFOP) is a rare clinicopathological condition. Studies in the literature have reported that AFOP may be associated with respiratory infections, such as respiratory syncytial virus, influenza virus, Pneumocystis jirovecii, Penicillium citrinum, and Chlamydia infections. However, AFOP associated with Legionella infection has not been reported previously. Read More

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In vivo generating SSA/Ro-antigen specific regulatory T cells improves experimental Sjögren's syndrome in mice.

Arthritis Rheumatol 2022 May 23. Epub 2022 May 23.

Mucosal Immunology Section, NIDCR, NIH, Bethesda, MD, 20892, USA.

Objective: Sjögren's syndrome (SS) is a systemic autoimmune disease and T cells play an important role in the initiation and perpetuation of the disease. Here, we developed an immunotherapy for SS-like NOD/Ltj mice by combining a transient depletion of CD4 T cells together with the administration of autoantigen-specific peptide Ro480.

Methods: NOD/Ltj mice were treated with single anti-CD4 mAb followed 2 days later by a series of 6 injections (i. Read More

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Circulating Th2 cell reduction and Th1/Th2 imbalance are correlated with primary Sjogren's syndrome-associated interstitial lung disease.

Arthritis Res Ther 2022 May 23;24(1):121. Epub 2022 May 23.

Department of Rheumatology, The Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.

Objective: Primary Sjogren's syndrome (pSS) is a heterogeneous chronic autoimmune disorder characterized by lymphocyte infiltration of the exocrine glands and the involvement and dysfunction of multiple organs and tissues. Interstitial lung disease (ILD) is the most common type of respiratory system damage. This study ascertained the factors related to ILD in patients with pSS (pSS-ILD), such as altered levels of circulating lymphocyte subtypes. Read More

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Case 302: Supratentorial Lymphocytic Inflammation with Parenchymal Perivascular Enhancement Responsive to Steroids.

Radiology 2022 Jun;303(3):726-730

From the Department of Radiology, Neuroradiology Section, University of Arkansas for Medical Sciences, Little Rock, Ark (S.V.); Department of Clinical Imaging, Hamad General Hospital (L.A.), and Department of Neuroradiology, Neuroscience Institute (M.A., A.H.E.B.), Hamad Medical, PO Box 3050, Alsadd, Doha, Qatar; and Department of Clinical Radiology, Weill Cornell Medicine, Doha, Qatar (A.H.E.B.).

History: Part one of this case appeared 4 months previously and may contain larger images. A 21-year-old immunocompetent man who was a long-term resident of Qatar presented to the emergency department with recurrent episodes of unprovoked generalized tonic-clonic seizures lasting 2-3 minutes that spontaneously resolved and were associated with postictal confusion. The patient also had progressive mild diplopia, intermittent dizziness, and numbness in the left arm over the course of 3 months. Read More

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Eltrombopag improves refractory thrombocytopenia in patients with Sjögren's syndrome.

Sci Prog 2022 Apr-Jun;105(2):368504221102786

Department of Rheumatology and Immunology, 74723The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.

Introduction: Eltrombopag, a kind of thrombopoietin (TPO) receptor agonist, plays the role on the megakaryocyte to activate the platelet production and rapidly increase the number of circulating platelets in patients with primary immune thrombocytopenia (ITP). Eltrombopag provides an opportunity for rapid tapering and/or cessation of corticosteroid therapy. However, it is not clear about the platelet response to Eltrombopag in ITP associated with Sjögren's Syndrome(SS). Read More

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Correlation Between Salivary Microbiome of Parotid Glands and Clinical Features in Primary Sjögren's Syndrome and Non-Sjögren's Sicca Subjects.

Front Immunol 2022 4;13:874285. Epub 2022 May 4.

Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, South Korea.

Recent studies have demonstrated that the oral microbiome in patients with Sjögren's syndrome (SS) is significantly different from that in healthy individuals. However, the potential role of the oral microbiome in SS pathogenesis has not been determined. In this study, stimulated intraductal saliva samples were collected from the parotid glands (PGs) of 23 SS and nine non-SS subjects through PG lavage and subjected to 16S ribosomal RNA amplicon sequencing. Read More

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Comorbidities in the UK Primary Sjögren's Syndrome Registry.

Front Immunol 2022 22;13:864448. Epub 2022 Apr 22.

Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom.

Introduction: Primary Sjögren's Syndrome (PSS) is a chronic disease characterised by symptoms of oral and ocular dryness, pain, fatigue, anxiety and depression. PSS patients can be subclassified by the pattern of severity of these five key symptoms using the Newcastle Sjögren's Stratification Tool (NSST). Although PSS is often associated with one or more comorbidities, the relationship between comorbidities, polypharmacy, and PSS symptom burden is unclear. Read More

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Efficacy and Safety of Acupuncture on Symptomatic Improvement in Primary Sjögren's Syndrome: A Randomized Controlled Trial.

Front Med (Lausanne) 2022 6;9:878218. Epub 2022 May 6.

Department of Rheumatology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.

Aim: We sought to evaluate the efficacy of acupuncture in treating the main symptoms of primary Sjögren's syndrome, specifically dryness, pain, and fatigue.

Methods: A total of 120 patients with primary Sjögren's syndrome were randomized in a parallel-group, controlled trial. Participants received acupuncture or sham acupuncture for the first 8 weeks, then were followed for 16 weeks thereafter. Read More

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Bone marrow-derived macrophages from a murine model of Sjögren's syndrome demonstrate an aberrant, inflammatory response to apoptotic cells.

Sci Rep 2022 May 21;12(1):8593. Epub 2022 May 21.

Department of Infectious Diseases and Immunology, College of Veterinary Medicine, University of Florida, PO Box 110880, Gainesville, FL, 32611-0880, USA.

Sjögren's syndrome (SjS) is a female-dominated autoimmune disease involving lymphocytic infiltration of the exocrine glands. We have previously demonstrated cleavage of the TAM (Tyro3, Axl, Mer) receptor Mer is enhanced in SjS, leading to defective efferocytosis. Mer also plays a role in modulating phagocyte inflammatory response to apoptotic cells. Read More

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Gut dysbiosis in rheumatic diseases: A systematic review and meta-analysis of 92 observational studies.

EBioMedicine 2022 May 17;80:104055. Epub 2022 May 17.

Department of Orthopaedics, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan 410008, China; Hunan Key Laboratory of Joint Degeneration and Injury, Changsha, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China. Electronic address:

Background: Emerging evidence suggests that dysbiosis in gut microbiota may contribute to the occurrence or development of several rheumatic diseases. Since gut microbiota dysbiosis is potentially modifiable, it has been postulated to be a promising preventive or therapeutic target for rheumatic diseases. However, the current understanding on the potential associations between gut microbiota and rheumatic diseases is still inadequate. Read More

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Impaired GATE16-mediated exocytosis in exocrine tissues causes Sjögren's syndrome-like exocrinopathy.

Cell Mol Life Sci 2022 May 20;79(6):307. Epub 2022 May 20.

Department of Diagnostic & Biomedical Sciences, School of Dentistry, The University of Texas Health Science Center at Houston, Houston, TX, 77054, USA.

Sjögren's syndrome (SjS) is a chronic autoimmune disease characterized by immune cell infiltration of the exocrine glands, mainly the salivary and lacrimal glands. Despite recent advances in the clinical and mechanistic characterization of the disease, its etiology remains largely unknown. Here, we report that mice with a deficiency for either Atg7 or Atg3, which are enzymes involved in the ubiquitin modification pathway, in the salivary glands exhibit a SjS-like phenotype, characterized by immune cell infiltration with autoantibody detection, acinar cell death, and dry mouth. Read More

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Association Between Endometriosis and Subsequent Risk of Sjögren's Syndrome: A Nationwide Population-Based Cohort Study.

Front Immunol 2022 3;13:845944. Epub 2022 May 3.

Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.

Objective: The relationship between endometriosis and the ensuing risk of Sjögren's syndrome has remained unclear. This study aims to present epidemiological evidence for this connection.

Methods: This is a retrospective cohort study of endometriosis patients (ICD-9-CM 617. Read More

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Overlap between Sjogren's syndrome and anti-synthetase syndrome: association or coincidence?

Arch Med Sci 2022 20;18(3):820-821. Epub 2022 Apr 20.

Department of Rheumatology and Immunology, Zhuzhou Hospital Affiliated to Xiangya Medical College, Central South University, Zhuzhou, Hunan, China.

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Sjögren's and non-Sjögren's sicca share a similar symptom burden but with a distinct symptom-associated proteomic signature.

RMD Open 2022 05;8(1)

Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK

Objectives: Given the similarity in symptoms between primary Sjogren's syndrome (SjS) and non-SjS sicca syndrome (sicca), we sought to characterise clinical and proteomic predictors of symptoms in both groups in order to better understand disease mechanisms and help guide development of immunomodulatory treatments. These have not, to date, unequivocally improved symptoms in SjS clinical trials.

Methods: Serum proteomics was performed using O-link inflammation and cardiovascular II panels. Read More

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Altered white matter structural connectivity in primary Sjögren's syndrome: a link-based analysis.

Neuroradiology 2022 May 19. Epub 2022 May 19.

Department of Radiology, Tianjin First Central Hospital, Tianjin Institute of Imaging Medicine, No.24 Fu Kang Road, Nan Kai District, Tianjin, 300192, China.

Purpose: Cognitive impairment has been revealed in primary Sjögren's syndrome (pSS). However, the underlying white matter structural connectivity (SC) changes have not been studied. This study aimed to investigate the altered white matter brain network in patients with pSS using diffusion tensor imaging (DTI). Read More

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Lacrimal Gland Insufficiency in Aqueous Deficiency Dry Eye Disease: Recent Advances in Pathogenesis, Diagnosis, and Treatment.

Semin Ophthalmol 2022 May 19:1-12. Epub 2022 May 19.

The Cornea Institute, L V Prasad Eye Institute, Hyderabad, India.

Background: Aqueous deficiency dry eye disease is a chronic and potentially sight-threatening condition, that occurs due to the dysfunction of the lacrimal glands. The aim of this review was to describe the various recent developments in the understanding, diagnosis and treatment of lacrimal gland insufficiency in aqueous deficiency dry eye disease.

Methods: A MEDLINE database search using PubMed was performed using the keywords: "dry eye disease/syndrome", "aqueous deficient/deficiency dry eye disease", "lacrimal gland" and "Sjogren's syndrome". Read More

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Impression Cytology and Confocal Microscopy of Lip Mucosa Compared With Labial Gland Biopsy and Classification Criteria In Patients With Clinically Suspected Primary Sjögren's Syndrome.

Front Immunol 2022 2;13:829320. Epub 2022 May 2.

Department of Ophthalmology, Peking University Third Hospital, Beijing, China.

Purpose: The study assessed the validity of impression cytology (IC) and confocal microscopy (IVCM) of lip mucosa compared with labial gland biopsy, anti-Sjögren's syndrome A (SSA)/Ro antibody status, and classification criteria in suspected primary Sjögren's syndrome (pSS) patients.

Methods: Clinically suspected pSS patients (n = 201) were enrolled consecutively and were divided into pSS (n = 56) and control (n = 145, only with dryness) groups according to the American College of Rheumatology-European League Against Rheumatism (ACR-EULAR) criteria. All patients underwent lip mucosa IC (inflammatory cell density) and IVCM (epithelium/intrinsic layer thickness and labial gland density/diameter) analyses. Read More

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The First Case Report of Preschool-Onset SS/SLE Coexisting With NMOSD of Chinese Origin.

Front Immunol 2022 2;13:887041. Epub 2022 May 2.

Department of Pediatrics, The Second Xiangya Hospital of Central South University, Changsha, China.

Systemic lupus erythematosus (SLE) is an autoimmune connective tissue disease (CTD), the main features of which are multiple serum autoantibodies and extensive involvement of multiple systems. The onset age of patients varies from childhood to middle age, with nearly 1/5 in childhood. Sjogren's syndrome (SS) is also an autoimmune disease characterized by high-degree lymphocytic infiltration of exocrine glands, usually occurring in middle-aged and older women, and rarely in childhood. Read More

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Acute polyneuropathy as the main manifestation of primary Sjogren's syndrome: A case report.

Clin Case Rep 2022 May 9;10(5):e05828. Epub 2022 May 9.

Clinical Research Development Unit Shahid Rajaei Educational & Medical Center Alborz University of Medical Sciences Karaj Iran.

Sjogren's syndrome is an inflammatory disease affecting many systems. We report a Sjogren case with the presenting feature of an acute motor-predominant polyneuropathy resembling Guillain-Barre syndrome. Upon further investigation, it was found that the patient had sicca symptoms for months. Read More

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Diabetic mastopathy: A rare clinicopathologic entity with considerable autoimmune potential.

Int J Surg Case Rep 2022 May 4;95:107151. Epub 2022 May 4.

Department of Surgery, King Fahad Specialist Hospital, Dammam, Saudi Arabia.

Introduction And Importance: Diabetic mastopathy is a rare entity affecting diabetic patients. It has been previously linked to type 1 diabetes mellitus; however, due to the several accompanying conditions, a theory of autoimmune factors contributing to the origin of this condition has been on the rise. In this paper, we report a case of diabetic mastopathy associated with several autoimmune diseases to highlight the immunological potential of this condition. Read More

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The NOD Mouse Beyond Autoimmune Diabetes.

Front Immunol 2022 29;13:874769. Epub 2022 Apr 29.

Immunology-Oncology Division, Maisonneuve-Rosemont Hospital Research Center, Montreal, QC, Canada.

Autoimmune diabetes arises spontaneously in Non-Obese Diabetic (NOD) mice, and the pathophysiology of this disease shares many similarities with human type 1 diabetes. Since its generation in 1980, the NOD mouse, derived from the Cataract Shinogi strain, has represented the gold standard of spontaneous disease models, allowing to investigate autoimmune diabetes disease progression and susceptibility traits, as well as to test a wide array of potential treatments and therapies. Beyond autoimmune diabetes, NOD mice also exhibit polyautoimmunity, presenting with a low incidence of autoimmune thyroiditis and Sjögren's syndrome. Read More

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Interaction Between Non-Coding RNAs and Interferons: With an Especial Focus on Type I Interferons.

Front Immunol 2022 27;13:877243. Epub 2022 Apr 27.

Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Interferons (IFNs) are a group of cellular proteins with critical roles in the regulation of immune responses in the course of microbial infections. Moreover, expressions of IFNs are dysregulated in autoimmune disorders. IFNs are also a part of immune responses in malignant conditions. Read More

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