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    Serum connective tissue growth factor is a highly discriminatory biomarker for the diagnosis of rheumatoid arthritis.
    Arthritis Res Ther 2017 Nov 22;19(1):257. Epub 2017 Nov 22.
    Department of Biochemistry, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, 325035, China.
    Background: Our previous proteomic study indicated that connective tissue growth factor (CTGF) may be a potential biomarker for rheumatoid arthritis (RA) diagnosis. The aim was to assess the performance of CTGF as a biomarker of RA.

    Method: Serum and synovial fluid CTGF was detected using a direct high sensitivity sandwich ELISA kit. Read More

    Antiphosphatidylserine/prothrombin antibodies (aPS/PT) as potential diagnostic markers and risk predictors of venous thrombosis and obstetric complications in antiphospholipid syndrome.
    Clin Chem Lab Med 2017 Nov 22. Epub 2017 Nov 22.
    Background: The aim of the study was to determine the prevalence and clinical associations of antiphosphatidylserine/prothrombin antibodies (aPS/PT) with thrombosis and pregnancy loss in Chinese patients with antiphospholipid syndrome (APS) and seronegative APS (SNAPS).

    Methods: One hundred and eighty six Chinese patients with APS (67 primary, 119 secondary), 48 with SNAPS, 176 disease controls (79 systemic lupus erythematosus [SLE], 29 Sjogren's syndrome [SS], 30 ankylosing spondylitis [AS], 38 rheumatoid arthritis [RA]) and 90 healthy donors were examined. IgG and IgM aPS/PT, IgG/IgM/IgA anticardiolipin (aCL) and IgG/IgM/IgA anti-β2-glycoprotein I (anti-β2GPI) antibodies were tested by ELISA. Read More

    Endoplasmic reticulum in health and disease: the 12th International Calreticulin Workshop, Delphi, Greece.
    J Cell Mol Med 2017 Nov 21. Epub 2017 Nov 21.
    School of Human Nutrition, McGill University, Ste. Anne de Bellevue, Quebec, Canada.
    Starting from 1994, every 2 years, an international workshop is organized focused on calreticulin and other endoplasmic reticulum chaperones. In 2017, the workshop took place at Delphi Greece. Participants from North and South America, Europe, Asia and Australia presented their recent data and discussed them extensively with their colleagues. Read More

    [Primary Sjögren syndrome in a child].
    Arch Pediatr 2017 Nov 17. Epub 2017 Nov 17.
    Service de médecine interne, CHU Hédi Chaker, 3029 Sfax, Tunisie.
    Sjögren syndrome is uncommon in children and occurs most often in association with autoimmune diseases (secondary Sjögren syndrome). We describe the clinical and biological features of a 7-year-old girl with primary Sjögren syndrome revealed by recurrent parotiditis.

    Case Report: A 7-year-old girl was referred for investigation of multiple episodes of parotid swelling since age 4 years, without systemic symptoms. Read More

    Small Fiber Neuropathy: Diagnosis, Causes, and Treatment.
    Joint Bone Spine 2017 Nov 15. Epub 2017 Nov 15.
    Département de Médecine Interne, Hôpital Lariboisière, APHP, 75010 Paris France; Université Paris Diderot, 75010 Paris, France. Electronic address:
    Small fiber neuropathy, which affects the sensory A≏ and C fibers, is now a major diagnostic and therapeutic challenge. Nearly 7% of the general population have chronic neuropathic pain responsible for severe quality-of-life impairments. Awareness must therefore be raised among clinicians of the somatosensory and autonomic symptoms that can reveal small fiber neuropathy, appropriate diagnostic investigations, most common causes, and best treatment options for each patient profile. Read More

    Y RNA derived small RNAs in Sjögren's syndrome: Candidate biomarkers?
    Int J Rheum Dis 2017 Nov 19. Epub 2017 Nov 19.
    Department of Immunology and Rheumatology, Christian Medical College, Vellore, Tamil Nadu, India.
    Anti-Ro and anti-La antibodies are important in pathogenesis and diagnosis of Sjögren's syndrome (SS). Ro60, Ro52 and La are RNA binding proteins of Y RNA, which were discovered more than three decades ago. Significance of Y RNA is not appreciated as much as Ro and La in SS. Read More

    A Case of Dermatomyositis Complicated by Digital Ischemia and Lung Adenocarcinoma in a Patient with Positive Anti-signal Recognition Particle Antibodies.
    Intern Med 2017 Nov 20. Epub 2017 Nov 20.
    Department of Medicine and Clinical Science, Division of Cardiology and Clinical Immunology, Yamaguchi University Graduate School of Medicine, Japan.
    A 58-year-old Japanese woman was diagnosed with anti-signal recognition particle (SRP)-positive dermatomyositis associated with Sjögren's syndrome, rheumatoid arthritis and lung adenocarcinoma. She presented with cutaneous lesions, including ulceration of her right middle finger. Tissue specimens obtained from her right deltoid muscle were positive for CD4(+) T-cell infiltration and the sarcolemma showed the upregulation of major histocompatibility complex (MHC) class I antigens. Read More

    Clinical and serological associations of anti-ribosomal P0 protein antibodies in systemic lupus erythematosus.
    Clin Rheumatol 2017 Nov 18. Epub 2017 Nov 18.
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, China.
    The purpose of this study is to investigate the clinical and serological associations of anti-ribosomal P0 protein antibodies (anti-Rib-P0) in patients with systemic lupus erythematosus (SLE). The sera of 470 patients with SLE and 124 patients with primary Sjogren's Syndrome (pSS) were collected. Line immunoassay (LIA) was used to detect anti-Rib-P0 and other related antibodies. Read More

    Rheumatic Manifestations in Autoimmune Liver Disease.
    Rheum Dis Clin North Am 2018 Feb;44(1):65-87
    Division of Rheumatology, Allergy, and Clinical Immunology, University of California, Davis, 4860 Y Street, Suite 2500, Sacramento, CA 95817, USA.
    Autoimmune liver diseases coexist with rheumatic disorders in approximately 30% of cases and may also share pathogenic mechanisms. Autoimmune liver diseases result from an immune-mediated injury of different tissues, with autoimmune hepatitis (AIH) targeting hepatocytes, and primary biliary cholangitis (PBC) and primary sclerosing cholangitis targeting cholangiocytes. Sjogren syndrome is diagnosed in 7% of AIH cases and serologic autoimmunity profiles are a common laboratory abnormality, particularly in the case of serum antimitochondrial (PBC) or anti-liver kidney microsomal antibodies (AIH). Read More

    Gastrointestinal and Hepatic Disease in Sjogren Syndrome.
    Rheum Dis Clin North Am 2018 Feb;44(1):143-151
    Rheumatology Division, University of Massachusetts Medical School, 119 Belmont Street, Worcester, MA 01605, USA.
    Sjogren syndrome (SS) is a lymphocyte-mediated, infiltrative autoimmune disorder characterized by destruction of exocrine glands leading to secretory dysfunction. The typical manifestations include xerostomia and xerophthalmia; however, extensive gastrointestinal involvement is increasingly being recognized, emphasizing the variable and systemic nature of SS. Read More

    Does Aromatase Inhibitors Cause Sjogren's Syndrome and Polyneuropathy?
    World J Oncol 2014 Aug 25;5(4):181-182. Epub 2014 Aug 25.
    Department of Internal Medicine, Division of Rheumatology, Eskisehir Osmangazi University, Eskisehir, Turkey.
    Aromatase inhibitors (AIs) are the indispensible part of hormone-responsive breast cancer treatment. A potential relation between autoimmunity and AIs has been described before. Herein, we report a case of Sjogren's syndrome (SjS) and polyneuropathy which developed during treatment with anastrozole. Read More

    Pneumoparotitis as a complication of long-term oronasal positive airway pressure for sleep apnea.
    Head Neck 2017 Nov 17. Epub 2017 Nov 17.
    University of Iowa Carver College of Medicine, Department of Otolaryngology - Head and Neck Surgery, Iowa City, Iowa.
    Background: Parotid swelling is rarely caused by pneumoparotitis from retrograde insufflation of air into Stensen's duct. Previous reports have identified occupational exposures, self-induced habits, exercise, spirometry, and short-term positive pressure airway ventilation as causes of salivary duct insufflation.

    Methods: We present 2 cases of pneumoparotitis in patients on long-term oronasal continuous positive airway pressure (CPAP) for obstructive sleep apnea. Read More

    Psychological comorbidities associated with subclinical atherosclerosis in Greek patients with primary Sjögren's syndrome: a potential contribution of sleep impairment.
    Clin Exp Rheumatol 2017 Nov 14. Epub 2017 Nov 14.
    Department of Physiology, School of Medicine, National and Kapodistrian University of Athens; Department of Pathophysiology, and Joint Academic Rheumatology Program, National and Kapodistrian University of Athens, Greece.
    Objectives: Impaired sleep and psychological disorders are increasingly recognised as prevalent comorbidities in patients with primary Sjögren's syndrome (pSS), as well as important contributors of atherosclerosis in the general population. In the current study we sought to explore a potential role of psychological comorbidities in the pronounced atherosclerotic risk of pSS patients.

    Methods: Fifty-nine pSS patients fulfilling the ACR/EULAR criteria completed specific validated questionnaires assessing fatigue, depression, anxiety and sleep disturbances. Read More

    Minor salivary gland fibrosis in Sjögren's syndrome is elevated, associated with focus score and not solely a consequence of aging.
    Clin Exp Rheumatol 2017 Oct 23. Epub 2017 Oct 23.
    Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation (OMRF); Department of Pathology, University of Oklahoma Health Sciences Center (OUHSC), Oklahoma City, OK, USA.
    Objectives: Evaluate the presence of minor salivary gland (SG) fibrosis in primary Sjögren's syndrome (pSS) as a function of disease pathology or a consequence of ageing.

    Methods: Subjects with sicca symptoms attending a Sjögren's research clinic were classified by American European Consensus Group (AECG) criteria as either pSS or non-SS (nSS). Discovery (n=34 pSS, n=28 nSS) and replication (n=35 pSS, n=31 nSS) datasets were evaluated. Read More

    [Clinical manifestation and gene analyses of 15 patients with intellectual disability or developmental delay complicated with congenital nystagmus].
    Zhonghua Er Ke Za Zhi 2017 Nov;55(11):824-829
    Department of Neurology, Children's Hospital Affiliated to Capital Institute of Pediatrics, Beijing 100020, China.
    Objective: To analyze the clinical and genetic features of 15 cases with intellectual disability or developmental delay (ID/DD) complicated with congenital nystagmus. Method: The clinical characteristics and the results of laboratory tests, images and genetics of 15 patients with ID/DD complicated with congenital nystagmus, confirmed by gene diagnosis in the Department of Neurology, Children's Hospital Affiliated to Capital Institute of Pediatrics from March 2015 to October 2016, were retrospectively analyzed. The physiological function of 13 disease genes and the molecular signaling pathways were also comparatively studied. Read More

    Familial aggregation of myasthenia gravis in affected families: a population-based study.
    Clin Epidemiol 2017 2;9:527-535. Epub 2017 Nov 2.
    Department of Anesthesiology, Chang Gung Memorial Hospital.
    Introduction: Myasthenia gravis (MG) is clinically heterogeneous and can be life-threatening if bulbar or respiratory muscles are involved. However, relative contributions of genetic, shared, and nonshared environmental factors to MG susceptibility remain unclear. The aim of this study was to examine the familial aggregation and heritability of MG and the relative risks (RRs) of other autoimmune diseases in the relatives of patients with MG. Read More

    Sjögren's syndrome initially presented as thrombotic thrombocytopenic purpura in a male patient: a case report and literature review.
    Clin Rheumatol 2017 Nov 13. Epub 2017 Nov 13.
    Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Dongdansantiao Street, Dongcheng District, Beijing, 100730, China.
    Thrombotic thrombocytopenic purpura (TTP) is a potentially lethal multisystem disorder which could be caused by autoimmune diseases. However, the concomitant occurrence of TTP and Sjögren's syndrome (SS) is an extremely uncommon scenario, especially in male patients. A 56-year-old Chinese male was admitted for the appearance of diffuse ecchymosis. Read More

    SATB1 Conditional Knockout Results in Sjögren's Syndrome in Mice.
    J Immunol 2017 Nov 10. Epub 2017 Nov 10.
    Department of Molecular Immunology, Toho University School of Medicine, Tokyo 143-8540, Japan;
    Sjögren's syndrome (SS) is an autoimmune disease in which exocrine tissues are affected by cellular and humoral immunity. As a result, the salivary and lacrimal glands of patients with SS are damaged, leading to xerostomia (dry mouth) and keratoconjunctivitis sicca (dry eyes). Because experimental approaches to investigate SS pathogenesis in human patients are limited, development of a mouse model is indispensable for understanding the disease. Read More

    The 2017 Doyne Lecture: the orbit as a window to systemic disease.
    Eye (Lond) 2017 Nov 10. Epub 2017 Nov 10.
    Orbital Plastic and Lacrimal Clinic, Royal Victorian Eye and Ear Hospital, and Centre for Eye Research Australia, University of Melbourne, Melbourne, Victoria, Australia.
    A very large number of disorders affect the orbit, and many of these occur in the setting of systemic disease. This lecture covers selected aspects of orbital diseases with systemic associations in which the author has a particular clinical or research interest. Spontaneous orbital haemorrhage often occurs in the presence of bleeding diatheses. Read More

    Oral dryness and Sjögren's: an update.
    Br Dent J 2017 Nov;223(9):649-654
    KCL Dental Institute at Guy's King's & St Thomas' Hospitals, Unit of Oral Medicine, Floor 23 Tower Wing, Guy's Hospital, Great Maze Pond, London, SE1 9RT.
    Oral dryness is a very common condition presenting to a general dental practitioner or hospital specialist. The most common cause of oral dryness is drug related, however, patients with Sjögren's syndrome, a multisystem autoimmune condition, may present to their dentist rather than their GP complaining of dry mouth and dry eyes. This update article explores the causes of oral dryness and how to manage it. Read More

    Low-level laser therapy for xerostomia in primary Sjögren's syndrome: a randomized trial.
    Clin Rheumatol 2017 Nov 9. Epub 2017 Nov 9.
    Department of Evidence-Based Health, Universidade Federal de São Paulo (UNIFESP), Rua Barão do Triunfo, 156/232, São Paulo, SP, 04602-000, Brazil.
    To evaluate the effectiveness of low-level laser therapy (LLLT) in the treatment of xerostomia in primary Sjögren's syndrome (SS), a randomized clinical trial of patients with dry mouth symptoms associated with primary SS receiving care at a university hospital was conducted. Sixty-six patients were randomly assigned with a 1:1 allocation ratio to receive LLLT (laser group, n = 33) or placebo treatment (placebo group, n = 33). Patients in the laser group received LLLT twice a week for 6 weeks, for a total of 12 treatment sessions. Read More

    B Cells Are Indispensable for a Novel Mouse Model of Primary Sjögren's Syndrome.
    Front Immunol 2017 24;8:1384. Epub 2017 Oct 24.
    Xiamen-Borstel Joint Laboratory of Autoimmunity, Medical College of Xiamen University, Xiamen, China.
    Primary Sjögren's syndrome (pSS) is characterized by a panel of autoantibodies, while it is not clear whether B cells and autoantibodies play an essential role in pathogenesis of the disease. Here, we report a novel mouse model for pSS which is induced by immunization with the Ro60_316-335 peptide containing a predominant T cell epitope. After immunization, mice developed several symptoms mimicking pSS, including a decreased secretion of tears, lymphocytic infiltration into the lacrimal glands, autoantibodies, and increased levels of inflammatory cytokines. Read More

    Salivary scintigraphy for Sjögren's syndrome in patients with xerostomia: a retrospective study.
    Oral Dis 2017 Nov 8. Epub 2017 Nov 8.
    Department of Dermatology, University François Rabelais of Tours, University Hospital of Tours, Tours, France.
    Objectives: The value of salivary gland scintigraphy in the diagnosis of Sjögren's syndrome remains controversial. The primary aim of this study was to estimate the diagnostic accuracy of salivary gland scintigraphy in the diagnosis of Sjögren's syndrome among 237 patients with xerostomia.

    Methods: We retrospectively compared eight scintigraphy parameters between 106 Sjögren patients and 131 non-Sjögren patients. Read More

    Neonatal Systemic Lupus Erythematosus Syndrome: a Comprehensive Review.
    Clin Rev Allergy Immunol 2017 Dec;53(3):469-476
    Pediatric intermediate care Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico and Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, Italy.
    Neonatal lupus erythematosus is an uncommon syndrome, which is caused by transplacental passage of maternal autoantibodies to Sjögren's syndrome A or B autoantigens. The clinical presentation includes distinctive cutaneous lesions resembling those seen in systemic lupus erythematosus, hepatobiliary disease, and cytopenias, which disappear with the clearance of maternal autoantibodies. The most severe presentation is a total atrioventricular heart block, which begins during the second trimester of gestation and is irreversible. Read More

    Therapeutic inhibitors for the treatment of dry eye syndrome.
    Expert Opin Pharmacother 2017 Nov 14:1-11. Epub 2017 Nov 14.
    a Department of Optics II (Optometry and Vision), Faculty of Optic and Optometry , Universidad Complutense de Madrid , Madrid , Spain.
    Introduction: Dry eye disease (DED), defined as a multifactorial disease of tears and ocular surface, results in symptoms of discomfort, ocular irritation, visual disturbance and tear film instability. This syndrome is accompanied of ocular surface inflammation and it is produced by a deficient activity of the lacrimal functional unit. In addition, it is associated with systemic autoimmune diseases such as Sjögren´s Syndrome, rheumatoid arthritis, systemic lupus erythematosus and some drug administration. Read More

    Hydroxychloroquine and risk of cancer in patients with primary Sjögren syndrome: propensity score matched landmark analysis.
    Oncotarget 2017 Oct 6;8(46):80461-80471. Epub 2017 Jul 6.
    Division of Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
    Hydroxychloroquine inhibits systemic inflammation and autophagy and may thus have antineoplastic effects [1]. We investigated the effect of hydroxychloroquine on cancer risk in patients with primary Sjögren syndrome(pSS). We used the Taiwan National Health Insurance Database to compare cancer incidence between incident pSS patients with or without at least 6-month hydroxychloroquine use within a 1- or 3-year period. Read More

    The RNA binding protein La/SS-B promotes RIG-I-mediated type I and type III IFN responses following Sendai viral infection.
    Sci Rep 2017 Nov 6;7(1):14537. Epub 2017 Nov 6.
    Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin 2, Ireland.
    La/SS-B (or La) is a 48 kDa RNA-binding protein and an autoantigen in autoimmune disorders such as systemic lupus erythematosus (SLE) and Sjögren's syndrome (SS). La involvement in regulating the type I interferon (IFN) response is controversial - acting through both positive and negative regulatory mechanisms; inhibiting the IFN response and enhancing viral growth, or directly inhibiting viral replication. We therefore sought to clarify how La regulates IFN production in response to viral infection. Read More

    Activation of plasmacytoid dendritic cells by apoptotic particles - mechanism for the loss of immunologic tolerance in Sjögren's syndrome.
    Clin Exp Immunol 2017 Nov 4. Epub 2017 Nov 4.
    Department of Internal Medicine and Rehabilitation, Helsinki University Central Hospital, and University of Helsinki, Helsinki, Finland.
    Sjögren's syndrome (SS) is a common autoimmune disease targeting salivary and lacrimal glands. It is strongly female-dominant characterized by low estrogen levels combined with a local intracrine dihydrotestosterone defect. We hypothesized that these hormonal deficits lead to increased apoptosis of the epithelial cells and plasmacytoid dendritic cell (pDC) mediated pro-inflammatory host responses. Read More

    [Myelitis as a differential diagnosis of spinal cord tumors].
    Neurochirurgie 2017 Nov 6;63(5):349-355. Epub 2017 Nov 6.
    Clinique neurologique, université de Lille Nord de France, CHU de Lille, Lille, France.
    Background And Purpose: Myelitis is common, related to multiple aetiologies and constitute in some cases a differential diagnosis for spinal cord tumors. Our objective was to review the clinical and paraclinical aspects of the main aetiologies of myelitis.

    Methods: These aetiologies will be reviewed based on data not only from the scientific literature but also from our personal experience reported in different cohorts of patients. Read More

    Manipulation of Panx1 Activity Increases the Engraftment of Transplanted Lacrimal Gland Epithelial Progenitor Cells.
    Invest Ophthalmol Vis Sci 2017 Nov;58(13):5654-5665
    Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California, United States.
    Purpose: Sjögren's syndrome is a systemic chronic autoimmune inflammatory disease that primarily targets the salivary and lacrimal glands (LGs). Currently there is no cure; therefore, cell-based regenerative therapy may be a viable option. LG inflammation is facilitated by extracellular ATP and mediated by the Pannexin-1 (Panx1) membrane channel glycoprotein. Read More

    Reduced Expression of VAMP8 in Lacrimal Gland Affected by Chronic Graft-versus-Host Disease.
    J Ophthalmol 2017 30;2017:1639012. Epub 2017 Sep 30.
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan.
    Purpose: To investigate whether the SNARE protein vesicle-associated membrane protein 8 (VAMP8) was implicated in the development of chronic ocular graft-versus-host disease (GVHD).

    Methods: Firstly, the chronic GVHD (cGVHD) and Sjögren's syndrome (SS)-impaired lacrimal gland (LG) tissue sections from humans for diagnostic purpose were evaluated for VAMP8 expression by histopathology and immunohistochemistry. Next, serial changes of tear secretion and VAMP8 expression at both protein and mRNA level of LG in an animal cGVHD model compared with the syngeneic control. Read More

    miRNA Expression Profile of Mucoepidermoid Carcinoma.
    Oral Dis 2017 Nov 2. Epub 2017 Nov 2.
    Sjögren's Syndrome and Salivary Gland Dysfunction Unit Molecular Physiology and Therapeutics, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, United States of America.
    Objectives: MicroRNAs (miRNAs) are single-stranded RNAs that have been implicated in cancer initiation and progression and act as tumour suppressors or oncogenes. In this study, miRNA profiling was conducted on the most frequent malignancy of salivary glands, mucoepidermoid carcinoma (MEC), with comparison to normal tissues.

    Materials And Methods: The TaqMan Human miRNA Cards Array was used for the miRNA profiling of MEC and normal tissues. Read More

    Hypertrophic Pachymeningitis in Sjögren's Syndrome.
    Intern Med 2017 Nov 1. Epub 2017 Nov 1.
    Department of Clinical Immunology and Rheumatology, The Tazuke-Kofukai Medical Research Institute, Kitano Hospital, Japan.
    Although central nervous system manifestations seem common in primary Sjögren's syndrome, hypertrophic pachymeningitis is rare. We herein describe a case of Sjögren's syndrome that was associated with hypertrophic pachymeningitis. Sjögren's syndrome should be considered as a cause of hypertrophic pachymeningitis. Read More

    Cytokines as therapeutic targets in primary Sjögren syndrome.
    Pharmacol Ther 2017 Oct 29. Epub 2017 Oct 29.
    Sjögren Syndrome Research Group (AGAUR), Laboratory of Autoimmune Diseases Josep Font, CELLEX-IDIBAPS, Spain; Autoimmune Diseases Unit, Department of Medicine, Hospital CIMA-Sanitas, Barcelona, Spain; Department of Autoimmune Diseases, ICMiD, Hospital Clínic Barcelona, Spain.
    Primary Sjögren syndrome (SjS) is a systemic autoimmune disease that may affect 1 in 1000 people (overwhelmingly women) and that can be a serious disease with excess mortality due to severe organ-specific involvements and the development of B cell lymphoma; systemic involvement clearly marks the disease prognosis, and strongly suggests the need for closer follow-up and more robust therapeutic management. Therapy is established according to the organ involved and severity. As a rule, the management of systemic SjS should be organ-specific, with glucocorticoids and immunosuppressive agents limited to potentially-severe involvements; unfortunately, the limited evidence available for these drugs, together with the potential development of serious adverse events, makes solid therapeutic recommendations difficult. Read More

    A qualitative exploration of physical, mental and ocular fatigue in patients with primary Sjögren's Syndrome.
    PLoS One 2017 31;12(10):e0187272. Epub 2017 Oct 31.
    Centre for Translational Inflammation Research, University of Birmingham, Birmingham, United Kingdom.
    Introduction: Primary Sjögren's Syndrome (pSS) affects exocrine glands such as those producing the tear film, leading to dry and painful eyes, but is also associated with fatigue. The experience of fatigue in pSS, and its relationship with sicca symptoms, is poorly understood.

    Methods: Twenty people diagnosed with pSS were recruited to participate in a semi-structured qualitative interview about their symptoms experience. Read More

    Cutaneous vasculitis in systemic lupus erythematosus patients: potential key players and implications.
    Lupus 2017 Jan 1:961203317739134. Epub 2017 Jan 1.
    4 Clinical Pathology (Immunology) Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
    Objectives The aim of the present work was to study the clinical characteristics of cutaneous vasculitis (CV) in systemic lupus erythematosus (SLE) patients and find possible potential key players in its development and implicated associations with the disease manifestations. Patients and methods Fifty adult female SLE patients underwent full history taking, thorough clinical examination and laboratory investigations. The SLE Disease Activity Index (SLEDAI) and accumulated damage using the Systemic Lupus International Collaborative Clinics/American College of Rheumatology Damage Index (SLICC/ACR DI) were assessed. Read More

    Productivity Losses and Costs in the Less-Common Systemic Autoimmune Rheumatic Diseases.
    Curr Rheumatol Rep 2017 Oct 30;19(11):72. Epub 2017 Oct 30.
    Arthritis Research Canada, Richmond, BC, Canada.
    Purpose Of Review: We synthesised the literature on productivity losses and costs in the less-common systemic autoimmune rheumatic diseases: Sjogren's syndrome (SjS), systemic sclerosis (SSc), poly/dermatomyositis (PM/DM), and systemic vasculitides (SV).

    Recent Findings: Of 29 studies located, 12 were published 2012 onwards (SSc = 6, SjS = 2, PM/DM = 2, SV = 2). In these, 25% of PM/DM, and 21-26% of SV, were work disabled, 22% of SSc stopped work within 3 years of diagnosis, and annual costs of absenteeism in SSc averaged $12,024 2017 USD. Read More

    Risk of Ischemic Heart Disease in Patients With Sjögren's Syndrome.
    Am J Med Sci 2017 Oct 4;354(4):395-398. Epub 2017 May 4.
    Department of Cardiovascular Diseases, Mercy Saint Vincent Medical Center, Toledo, Ohio.
    Background: Ischemic heart disease (IHD) has emerged as a major cause of morbidity and mortality in patients with autoimmune conditions such as systemic lupus erythematosus and rheumatoid arthritis, but the risk of IHD in Sjögren's syndrome (SjS) is unknown. To fill this knowledge gap, we estimated the prevalence and risk of IHD with SjS compared to controls from the general population using the Healthcare Cost and Utilization Project National Inpatient Sample 2011 database.

    Materials And Methods: The Healthcare Cost and Utilization Project administrative longitudinal database contains encounter-level information on inpatient stays, emergency department visits and ambulatory surgery in all U. Read More

    Defective regulation of L1 endogenous retroelements in primary Sjogren's syndrome and systemic lupus erythematosus: Role of methylating enzymes.
    J Autoimmun 2017 Oct 23. Epub 2017 Oct 23.
    Mary Kirkland Center for Lupus Research, Hospital for Special Surgery, Weill Medical College of Cornell University, New York, NY 10021, USA. Electronic address:
    Objective: To investigate whether altered DNA methylation contributes to the inappropriate expression of LINE-1 (L1) retroelements in primary Sjogren's syndrome (SS) and systemic lupus erythematosus (SLE).

    Methods: Minor salivary glands (MSG) were obtained from 42 patients with primary SS [23 without adverse predictors for lymphoma development (SS-low risk), 7 SS-high risk and 12 complicated by B-cell lymphoma (SS-lymphoma)] and 17 sicca controls (SC). Additionally, kidney biopsy specimens and PBMCs were obtained from 23 and 73 lupus patients, respectively. Read More

    Antigen-driven lymphoproliferations in Sjögren's Syndrome patients accumulate in complement receptor 2/CD21(-/low) B cells.
    Arthritis Rheumatol 2017 Oct 26. Epub 2017 Oct 26.
    Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA.
    Objective: Sjögren's Syndrome (SS) patients are prone to develop malignant lymphomas and a correlation has been established between lymphoproliferations and the presence in patients' blood of an unusual B cell population that downregulated complement receptor 2/CD21. We sought to determine from which B cell compartment lymphoproliferations in SS patients emerge and what are the mechanisms that promote these clonal B cell expansions.

    Methods: Using a PCR-based approach that allows us to clone and express, in vitro, recombinant antibodies produced by single B cells, we tested the reactivity of antibodies expressed by CD19(+) CD10(-) CD27(-) IgM(+) CD21(-/low) cells from SS patients. Read More

    Patients with primary Sjögren's syndrome have alterations in absolute quantities of specific peripheral leukocyte populations.
    Scand J Immunol 2017 Oct 26. Epub 2017 Oct 26.
    Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway.
    An accurate dissection of peripheral blood enumeration is lacking in primary Sjögren's syndrome. The purpose of this study was to quantify different leukocyte populations in peripheral blood of patients with pSS. Numbers of specific leukocyte subsets were determined in 86 pSS patients and 74 healthy donors quantifying 21 distinct subtypes by flow cytometry. Read More

    Sex influences eQTL effects of SLE and Sjögren's syndrome-associated genetic polymorphisms.
    Biol Sex Differ 2017 Oct 25;8(1):34. Epub 2017 Oct 25.
    Unit of Experimental Rheumatology, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden.
    Background: Systemic lupus erythematosus (SLE) and primary Sjögren's syndrome (pSS) are autoimmune disorders characterized by autoantibodies, dysregulated B cells, and notably high female-to-male incidence ratios. Genome-wide association studies have identified several susceptibility SNPs for both diseases. Many SNPs in the genome are expression quantitative trait loci (eQTLs), with context-dependent effects. Read More

    Ultrasound of the Major Salivary Glands is a Reliable Imaging Technique in Patients with Clinically Suspected Primary Sjögren's Syndrome.
    Ultraschall Med 2017 Oct 25. Epub 2017 Oct 25.
    Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, Netherlands.
    Objective To assess the inter- and intraobserver reliability of ultrasound of major salivary glands in patients clinically suspected of having primary Sjögren's syndrome (pSS) as well as to assess sources of variation in outcomes of ultrasonographic evaluation. Methods 80 consecutive outpatients with clinically suspected pSS underwent ultrasound evaluation. The following ultrasound variables of the parotid and submandibular salivary glands were assessed: echogenicity, parenchymal homogeneity, presence of hypoechogenic areas, hyperechogenic reflections and clearness of posterior glandular border, according to the scoring system of Hocevar et al. Read More

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