25,272 results match your criteria Sinusitis Fungal


Antibiotic prescriptions to adults with acute respiratory tract infections by Italian general practitioners.

Infect Drug Resist 2018 8;11:2199-2205. Epub 2018 Nov 8.

Department of Health Sciences, Medical School, University of Catanzaro "Magna Græcia", Catanzaro, Italy,

Purpose: The overuse, misuse, and underuse of antimicrobial agents often lead to the spread of antibiotic-resistant microorganisms. The aim of our study was to describe the pattern of antibiotic prescriptions for acute respiratory tract infections (RTIs) among the adult population and the factors associated with antibiotic prescribing.

Patients And Methods: The study involved patients who visited a general practitioner with suspected acute RTI. Read More

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November 2018
1 Read

The role of surfactant protein-A in sinusitis.

Authors:
Eugene H Chang

Curr Opin Allergy Clin Immunol 2018 Nov 29. Epub 2018 Nov 29.

Department of Otolaryngology - Head & Neck Surgery, University of Arizona College of Medicine, Tucson, Arizona, USA.

Purpose Of Review: Surfactant protein-A (SP-A) is a collectin protein expressed in airway epithelia that is critical in the modulation of both innate and adaptive immunity against inhaled pathogens. In this review, we highlight associations of altered SP-A function in asthma and chronic rhinosinusitis, and its potential role as a targeted therapy for sinusitis.

Recent Findings: SP-A has been shown to bind and opsonize inhaled pathogens, thereby clearing bacteria through phagocytosis. Read More

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November 2018

Current indications for balloon sinuplasty.

Curr Opin Otolaryngol Head Neck Surg 2018 Nov 30. Epub 2018 Nov 30.

Rhinology & Endoscopic Skull Base Surgery, UCLA Department of Head & Neck Surgery, Los Angeles, California, USA.

Purpose Of Review: The purpose of the review is to evaluate the current indications and contraindications for balloon sinuplasty and review the clinical trials performed in this area.

Recent Findings: The indications for balloon sinus dilatation are somewhat similar to those for endoscopic sinus surgery. Balloon sinus ostial dilation (BSD) has been found to be most effective in the treatment of recurrent acute sinusitis (RARS) and chronic rhinosinusitis without nasal polyposis (CRSsNP) that has been refractory to medical therapy. Read More

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November 2018
1 Read

Nasal septal abscess: a 10-year retrospective study.

Eur Arch Otorhinolaryngol 2018 Nov 30. Epub 2018 Nov 30.

Department of Otolaryngology-Head and Neck Surgery, Tri-Service General Hospital, National Defense Medical Center, No. 325, Cheng-Kung Road Section 2, Taipei 114, Taiwan, ROC.

Objective: Nasal septal abscess is an uncommon condition but it can cause potentially life-threatening intracranial complications and cosmetic nasal deformity.

Methods: We analyzed ten years of cases to determine the optimal diagnostic and therapeutic modalities. A retrospective review of case notes from Tri-Service General Hospital archives was performed. Read More

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November 2018
3 Reads

The microbiome and chronic rhinosinusitis.

World J Otorhinolaryngol Head Neck Surg 2018 Sep 31;4(3):216-221. Epub 2018 Oct 31.

Department of Surgery, The University of Auckland, Grafton, Auckland, New Zealand.

Chronic rhinosinusitis (CRS) is a multifactorial condition in which the microbiota plays a pathogenic role. The nature of the interaction between the microbiota and the local immune system is very complex and has not been fully elucidated. Recent improvements in the microbiological techniques have greatly advanced our understanding of the complex nature of this interaction. Read More

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September 2018
1 Read

Acquired cystic fibrosis transmembrane conductance regulator dysfunction.

World J Otorhinolaryngol Head Neck Surg 2018 Sep 31;4(3):193-199. Epub 2018 Oct 31.

Department of Otolaryngology Head & Neck Surgery, University of Alabama at Birmingham, Birmingham, AL, USA.

Sinonasal respiratory epithelium is a highly regulated barrier that employs mucociliary clearance (MCC) as the airways first line of defense. The biological properties of the airway surface liquid (ASL), combined with coordinated ciliary beating, are critical components of the mucociliary apparatus. The ASL volume and viscosity is modulated, in part, by the cystic fibrosis transmembrane conductance regulator (CFTR). Read More

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September 2018
2 Reads

Current understanding of allergic fungal rhinosinusitis.

World J Otorhinolaryngol Head Neck Surg 2018 Sep 9;4(3):179-185. Epub 2018 Nov 9.

McGovern Medical School at the University of Texas Health Science Center, Department of Otorhinolaryngology-Head & Neck Surgery, Houston, TX 77030, USA.

Studying the pathophysiology of allergic fungal rhinosinusitis (AFRS) has proved challenging. While this clinical entity is easily distinguishable based on the clinical criteria set forth by Bent and Kuhn twenty-five years ago, studies examining type 2 inflammatory profiles in AFRS can make it seem more alike other CRS subtypes than it is different. Still, evolving research seems to clearly delineate this subtype from others in CRS. Read More

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September 2018
1 Read

P-glycoprotein and chronic rhinosinusitis.

World J Otorhinolaryngol Head Neck Surg 2018 Sep 24;4(3):169-174. Epub 2018 Aug 24.

Department of Otolaryngology, Santa Casa de Sao Paulo School of Medical Sciences, RuaDoutorCesário Motta Júnior, 61 - Vila Buarque, São Paulo, SP, 01221-020, Brazil.

Chronic rhinosinusitis (CRS) is a heterogeneous definition that includes different disease states that usually are associated with abnormal inflammatory responses. Besides being prevalent, the mechanisms involved in its pathogenesis are not clear and there are few therapeutic options with tolerable side effects. P-glycoprotein (P-gp) is an efflux pump responsible of extruding xenobiotics and cellular metabolites from multiple cell types. Read More

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September 2018
2 Reads

Brain MRI and cognitive function seven years after surviving an episode of severe acute malnutrition in a cohort of Malawian children.

Public Health Nutr 2018 Dec 3:1-9. Epub 2018 Dec 3.

2Malawi-Liverpool-Wellcome Trust Clinical Research Programme,Blantyre,Malawi.

Objective: To assess differences in cognition functions and gross brain structure in children seven years after an episode of severe acute malnutrition (SAM), compared with other Malawian children.

Design: Prospective longitudinal cohort assessing school grade achieved and results of five computer-based (CANTAB) tests, covering three cognitive domains. A subset underwent brain MRI scans which were reviewed using a standardized checklist of gross abnormalities and compared with a reference population of Malawian children. Read More

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December 2018

Relations pathologiques entre dents et sinus maxillaire.

Rev Prat 2016 Mar;66(3):309-314

Service d'ORL et de chirurgie cervico-faciale, hôpital d'instruction des armées Percy, Clamart, France.

Pathological link between teeth and maxillary sinus. Pathological relationship between the teeth and the maxillary sinus can be explained by their embryological and anatomical relationships. The floor is centered by the apex of antral teeth: premolars and first molars. Read More

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Surgical approach of isolated fracture of the anterior wall of the frontal sinus: the upper eyelid incision.

J Stomatol Oral Maxillofac Surg 2018 Nov 26. Epub 2018 Nov 26.

Department of Maxillofacial Surgery, Nantes University Hospital, 1 place Alexis-Ricordeau, 44093 Nantes cedex 1, France.

Fractures of the frontal sinus are classified according to the topography (anterior wall, posterior wall or both), the displacement, and the presence of associated lesions (wound, nasofrontal duct injury, rhinorrhea). Isolated fractures of the anterior wall require surgical management, if the displacement is over 4 mm, to restore the forehead symmetry, to maintain the sinus ventilation and to avoid long-term complications (sinusitis, mucocele, meningitis…). Coronal incision is commonly performed but less invasive techniques are more and more used. Read More

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November 2018

Septicemia, Meningitis and Bilateral Subdural Empyema in an Infant Caused by Staphylococcus aureus.

Mymensingh Med J 2018 Oct;27(4):898-903

Dr Shameem Ahmed, Senior Consultant Neurosurgeon, Department of Neurosurgery, Apollo Hospitals (Unit: International Hospital), Guwahati , India.

Staphylococcus aureus is a global bacterial pathogen. It is an uncommon pathogen causing central nervous system infections, accounting for <1% cases of bacterial meningitis. Sinusitis, trauma and presence of an intracranial device have been reported as risk factors for developing meningitis and brain abscesses. Read More

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October 2018
1 Read

Incidence and risk factors of new-onset hypertrophic pachymeningitis in patients with anti-neutrophil antibody-associated vasculitis: using logistic regression and classification tree analysis.

Clin Rheumatol 2018 Nov 27. Epub 2018 Nov 27.

Department of Nephrology Center, Toranomon Hospital, 2-2-2, Toranomon, Minatoku, 105-8470, Japan.

Objectives: Hypertrophic pachymeningitis (HP) is a rare complication in patients with anti-neutrophil antibody-associated vasculitis (AAV); its clinical features, incidence, and risk factors remain unknown. We aimed to clarify the prevalence, clinical features, and factors associated with new-onset HP in patients with AAV.

Method: A retrospective cohort study involving 93 patients with AAV was conducted. Read More

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November 2018

Odontogenic rhinosinusitis and sinonasal complications of dental disease or treatment: prospective validation of a classification and treatment protocol.

Eur Arch Otorhinolaryngol 2018 Nov 27. Epub 2018 Nov 27.

Otolaryngology Unit, Department of Health Sciences, San Paolo Hospital, University of Milan, Via A. di Rudinì, 8, 20142, Milan, Italy.

Purpose: Odontogenic sinusitis and sinonasal complications of dental disease or treatment (SCDDT) represent a heterogeneous group of conditions that often require multidisciplinary care. The present study aims to prospectively validate a classification and treatment protocol for SCDDT patients.

Methods: One hundred twenty-eight consecutive patients (73 females and 45 males, mean age 52. Read More

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November 2018

Isolation of multidrug-resistant Haemophilus influenzae harbouring multiple exogenous genes from a patient diagnosed with acute sinusitis.

J Infect Chemother 2018 Oct 25. Epub 2018 Oct 25.

Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Japan. Electronic address:

In paediatric patients, β-lactams and macrolides are widely used to treat acute otitis media and sinusitis, which are often caused by either Streptococcus pneumoniae or Haemophilus influenzae. However, resistant isolates have emerged and are becoming more prevalent. H. Read More

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October 2018

Endoscopic and Radiologic Findings in Failed Dacryocystorhinostomy: Teaching Pearls for Success.

Am J Rhinol Allergy 2018 Nov 28:1945892418815044. Epub 2018 Nov 28.

4 Department of Otolaryngology-Head & Neck Surgery, Albaha University, Al Bahah, Saudi Arabia.

Background: Although several studies have commented on causes of dacryocystorhinostomy (DCR) failure, detailed description of anatomical findings in such cases remains insufficient.

Objective: Our objective was primarily to analyze radiologic, endoscopic, and intraoperative findings in patients presenting with failed DCR and secondarily to assess the outcome of revision endoscopic DCR (endo-DCR) carried out at our institution.

Methods: Twenty-four failed DCRs presenting to our tertiary care center were retrospectively analyzed. Read More

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November 2018
2 Reads

Complementary and Alternative Medicine in Chronic Rhinosinusitis: A Systematic Review and Qualitative Analysis.

Am J Rhinol Allergy 2018 Nov 28:1945892418813079. Epub 2018 Nov 28.

1 Dalhousie Medicine New Brunswick, Saint John, New Brunswick, Canada.

Background: Complementary and alternative medicine (CAM) is frequently used in the treatment of chronic rhinosinusitis (CRS) in developed countries. With a plethora of CAM therapies available, their effectiveness and safety are poorly understood in the context of CRS.

Objectives: This article aims to critically appraise the evidence for CAM use in CRS through a systematic review of current literature that investigate the effects of CAM on symptoms and clinical status of adults with CRS. Read More

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November 2018
1 Read

The Microbiology of Complicated Acute Sinusitis among Pediatric Patients: A Case Series.

Otolaryngol Head Neck Surg 2018 Nov 27:194599818815109. Epub 2018 Nov 27.

3 Division of Otolaryngology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.

Objective: The microbiology of pediatric complicated acute rhinosinusitis (ARS) has evolved, and our current understanding of pathogenic organisms is limited. The objectives of this study are to describe the incidence of pathogens causing complicated ARS requiring surgical intervention at our institution over a 10-year period as well as their associated treatment outcomes.

Study Design: Retrospective cohort study. Read More

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November 2018
4 Reads

The Bifurcated Frontal Sinus.

OTO Open 2018 Jan-Mar;2(1):2473974X18764879. Epub 2018 Mar 13.

Ochsner Clinic School, University of Queensland, New Orleans, Louisiana, USA.

Objectives: Frontal sinus anatomy is complex, and multiple variations of ethmoid pneumatization have been described that affect the frontal outflow tract. In addition, the lumen proper of the frontal sinus may exist as 2 separate parallel cavities that share an ipsilateral outflow tract. This variant has not been previously described and may have implications for surgical management. Read More

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March 2018
6 Reads

Effectiveness of benralizumab for allergic and eosinophilic predominant asthma following negative initial results with omalizumab.

Respirol Case Rep 2019 Jan 21;7(1):e00388. Epub 2018 Nov 21.

Department of Respiratory Medicine National Hospital Organization Okayama Medical Center Okayama City Okayama Japan.

A 64-year-old woman, who had presented with a 30-year history of refractory asthma, and been treated with anti-allergic drug therapy, inhaled corticosteroids, a long-acting beta-agonist, and a long-acting muscarinic antagonist. She had been characterized as an allergic, eosinophilic asthmatic. Although omalizumab was tried initially, it was found to be insufficient. Read More

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January 2019

Histoplasma capsulatum causing sinusitis: a case report in French Guiana and review of the literature.

BMC Infect Dis 2018 Nov 26;18(1):595. Epub 2018 Nov 26.

AcademicLaboratory of Parasitology and Mycology, Andrée Rosemon Hospital, 97306, Cayenne, French Guiana.

Background: American histoplasmosis is a mycosis caused by Histoplasma capsulatum. A variety of clinical features of histoplasmosis have been commonly described ranging from asymptomatic infections to severe pulmonary infections. In immunocompromised individuals, progressive disseminated forms are frequent, leading to fatal outcome if untreated. Read More

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November 2018

Recurrent Pott's Puffy Tumor Treated With Anterior Skull Base Resection With Reconstruction of the Anterolateral Thigh Flap.

J Craniofac Surg 2018 Nov 20. Epub 2018 Nov 20.

Department of Otorhinolaryngology, Dokkyo Medical University Saitama Medical Center.

Pott's puffy tumor (PPT) is a rare, life-threatening complication of frontal sinusitis that is treated with a combination of appropriate antibiotics and surgery for the removal of infected tissue. A 56-year-old man with recurrent forehead swelling was admitted and diagnosed with recurrent PPT. He had undergone endoscopic sinus surgery and pericranial abscess drainage. Read More

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November 2018

Successful rituximab treatment of granulomatosis with polyangiitis with cranial neuropathies.

Inflamm Regen 2018 19;38:20. Epub 2018 Nov 19.

Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, Japan.

Background: In granulomatosis with polyangiitis (GPA), peripheral nerve involvement is common but central nervous system (CNS) involvement is extremely rare and treatment strategy has not been established. We report a case of intravenous cyclophosphamide (IVCY)-resistant GPA with associated cranial neuropathies that was successfully treated with rituximab (RTX).

Case Presentation: A 37-year-old man with intractable sinusitis had several months of headache, hoarseness, and dysphagia; a month of right-sided deafness and nasal bleeding; and a week of dysarthria, steppage gait, and numbness in the right L5 distribution. Read More

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November 2018
1 Read

Update on the diagnostic considerations for neurogenic nasal and sinus symptoms: A current review suggests adding a possible diagnosis of migraine.

Am J Otolaryngol 2018 Oct 2. Epub 2018 Oct 2.

Headache Medicine, Yale Neuroscience Center, New Haven, CT, USA. Electronic address:

Background: Treatment of rhinosinusitis (RS) is one of the leading reasons for prescriptions of antibiotics, although they often fail to provide symptomatic relief. Appropriately diagnosing and treating patients presenting with RS for whom antibiotic therapy has failed or who have normal CT findings is a controversial topic. One explanation is that what these patients are experiencing is misinformation from the trigeminal nerve and autonomic nervous system. Read More

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October 2018
3 Reads

Ivacaftor improves rhinologic, psychologic, and sleep-related quality of life in G551D cystic fibrosis patients.

Int Forum Allergy Rhinol 2018 Nov 24. Epub 2018 Nov 24.

Department of Otolaryngology-Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, AL.

Background: Ivacaftor is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator that improves pulmonary function in cystic fibrosis (CF) patients with at least 1 copy of the G551D CFTR mutation. The purpose of this study is to evaluate the impact of ivacaftor on chronic rhinosinusitis (CRS) symptoms in this population.

Methods: The G551D Observational (GOAL) study was a multicenter prospective cohort study enrolling CF patients ≥6 years with at least 1 G551D mutation. Read More

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November 2018
3 Reads

In vitro analysis of growth patterns of invasive fungal species on commonly used endonasal hemostatic agents.

Am J Otolaryngol 2019 Jan - Feb;40(1):101-105. Epub 2018 Sep 25.

Department of Otolaryngology-Head and Neck Surgery, Augusta University, 1120 15th Street, BP-4109, Augusta, GA 30912, United States of America.

Objective: Previous studies have not examined the potential role of endonasal hemostatic agents in facilitating growth of fungal species. We aim to determine the possibility of these to serve as a nutrient source for fungal growth.

Methods: Cultures of Aspergillus, Fusarium, and Mucor were harvested and placed in solution in sterile saline at standardized high and low concentrations. Read More

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September 2018
1 Read

Clinical efficacy of intranasal drug delivery by nebulization in chronic rhinosinusitis: a systematic review.

Rhinology 2018 Nov 24. Epub 2018 Nov 24.

Service d'Oto-rhino-laryngologie, Cliniques universitaires Saint-Luc, Brussels, Belgium.

Background: Treatment of chronic rhinosinusitis (CRS) aims to treat the underlying inflammation or infection. Although the optimal modality of administration remains controversial, inhalation route is usually preferred. The aim of this systematic review was to summarize the efficacy of intranasal corticoisteroids or antibiotics delivery by nebulization on symptoms, histology, endoscopy scores, nasal obstruction, clinical outcomes and quality of life in CRS. Read More

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November 2018
1 Read

Anatomical variation in maxillary sinus ostium positioning: implications for nasal-sinus disease.

Anat Rec (Hoboken) 2018 Nov 24. Epub 2018 Nov 24.

Des Moines University, College of Osteopathic Medicine, Department of Anatomy, 3200 Grand Ave, Des Moines, IA, 50312, USA.

Among humans, superiorly located maxillary sinus ostia (MSO) result in drainage complications and maxillary sinus (MS) disease. While previous studies investigate maxillary sinusitis frequency or MSO-position relative to specific nasal landmarks, few explore MSO-position to overall MS dimensions. This study investigates whether MSO-position relates to MS size/shape and if sex-based differences exist. Read More

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November 2018
3 Reads

Epimagnolin A, a tetrahydrofurofuranoid lignan from Magnolia fargesii, reverses ABCB1-mediated drug resistance.

Phytomedicine 2018 Dec 20;51:112-119. Epub 2018 Jun 20.

Department of Applied Biological Chemistry, Graduate School of Bioscience and Biotechnology, Chubu University, 1200 Matsumoto-cho, Kasugai, Aichi 487-8501, Japan. Electronic address:

Background: Epimagnolin A is an ingredient of the Chinese crude drug Shin-i, derived from the dried flower buds of Magnolia fargesii and Magnolia flos, which has been traditionally used for the treatment of allergic rhinitis and nasal congestion, empyema, and sinusitis. The pharmacokinetic activity of epimagnolin A remains to be evaluated.

Purpose: In this study, we examined the possible interactions of epimagnolin A with human ATP-binding cassette (ABC) transporter ABCB1, a membrane protein vital in regulating the pharmacokinetics of drugs and xenobiotics. Read More

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December 2018
1 Read

Characteristics of Intracranial Group A Streptococcal Infections in US Children, 1997-2014.

J Pediatric Infect Dis Soc 2018 Nov 21. Epub 2018 Nov 21.

Respiratory Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia.

Background: Few data on intracranial group A Streptococcus (GAS) infection in children are available. Here, we describe the demographic, clinical, and diagnostic characteristics of 91 children with intracranial GAS infection.

Methods: Cases of intracranial GAS infection in persons ≤18 years of age reported between 1997 and 2014 were identified by the Centers for Disease Control and Prevention's population- and laboratory-based Active Bacterial Core surveillance (ABCs) system. Read More

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November 2018
3 Reads

Sinusitis Update.

Emerg Med Clin North Am 2019 Feb;37(1):41-54

Department of Emergency Medicine, Division of International EM Stony Brook University (SUNY), 101 Nicholls Road, HSC Level 4, Stony Brook, NY 11794, USA.

Rhinosinusitis affects many pediatric patients as well as 1 in 6 adults in any given year, resulting in ambulatory care, pediatric, and emergency department visits. Uncomplicated rhinosinusitis requires no imaging or testing and does not require antibiotic treatment. Using strict clinical diagnostic criteria may minimize unnecessary antibiotics. Read More

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February 2019
6 Reads

[One case of oculomotor nerve paralysis caused by chronic ethmoidal sinusitis].

Authors:
A L Zhou X P Hou

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Nov;53(11):856-857

Department of Otorhinolaryngology Head and Neck Surgery, General Hospital of Gujiao Coal Mine, TaiYuan 030200, China.

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November 2018

[Predictive study on recurrence of chronic sinusitis with nasal polyps by tissue eosinophils and sinus CT].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Nov;53(11):842-846

Department of Otorhinolaryngology Head and Neck Surgery, First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.

To investigate the correlation between postoperative recurrence and clinical parameters in patients with chronic rhinosinusitis with nasal polyps (CRSwNP), and to study predicitve value of total scores of eosinophils (EOS) and sinus CT for postoperative recurrence. A retrospective analysis of 264 patients with CRSwNP who were admitted to the First Affiliated Hospital of Wenzhou Medical University from June 2013 to December 2015 was performed. The patient was subjected to a visual analogue scale (VAS) score, a skin prick test, a peripheral blood cell count, a sinus CT score, and a nasal polyp EOS count. Read More

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November 2018
1 Read

In-office balloon sinus dilation versus medical therapy for recurrent acute rhinosinusitis: a randomized, placebo-controlled study.

Int Forum Allergy Rhinol 2018 Nov 19. Epub 2018 Nov 19.

The Sinus & Respiratory Disease Center at the Texas Institute, Dallas, TX.

Background: A limited number of studies have demonstrated symptomatic improvement for recurrent acute rhinosinusitis (RARS) patients after endoscopic sinus surgery. In this randomized, controlled study we evaluated 24-week outcomes for balloon sinus dilation (BSD) performed in-office (IO) with medical management (MM) as compared with MM only for RARS patients.

Methods: Adults diagnosed with RARS were randomized to groups with BSD plus MM (n = 29) or MM alone (n = 30). Read More

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November 2018
3 Reads

Fungus Ball of the Maxillary Sinus-Modern Treatment by Osteoplastic Approach and Functional Endoscopic Sinus Surgery.

J Oral Maxillofac Surg 2018 Oct 24. Epub 2018 Oct 24.

Department Head, Department of Oral and Maxillofacial Surgery, University Hospital Tuebingen, Tuebingen, Germany.

Purpose: Functional endoscopic sinus surgery (FESS) is considered standard surgical therapy for fungus ball of the maxillary sinus. However, recent findings have indicated an odontogenic etiology, which requires simultaneous treatment of the dental origin. This study presents the authors' treatment results of fungus ball of the maxillary sinus using a combination of FESS and an endoscopically assisted osteoplastic approach through the anterior wall of the maxillary sinus, enabling simultaneous treatment of the dental origin. Read More

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October 2018
3 Reads

Association between chronic somatic conditions and depression in children and adolescents: A retrospective study of 13,326 patients.

J Affect Disord 2018 Nov 5;245:697-701. Epub 2018 Nov 5.

Faculty of Medicine, University of Paris 5, Paris, France.

Aims: The goal of this study was to analyze the association between chronic somatic conditions and depression diagnosis in children and adolescents.

Methods: The present case-control study included 13,326 children and adolescents with depression as well as controls without depression followed in 243 pediatric practices between 2010 and 2015. Cases and controls were matched by age, gender, index year, and physician. Read More

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November 2018
3 Reads

Galcanezumab in chronic migraine: The randomized, double-blind, placebo-controlled REGAIN study.

Neurology 2018 Nov 16. Epub 2018 Nov 16.

From Eli Lilly and Company, Indianapolis, IN (H.C.D., S.W., K.J.S., S.K.A.); Department of Neurology (P.J.G.), NIHR-Wellcome Trust King's Clinical Research Facility, King's College London, UK; University of California (P.J.G.), San Francisco; and Departments of Neurology and Neurotherapeutics and Ophthalmology, University of Texas Southwestern Medical Center, Dallas.

Objective: To evaluate the efficacy and safety of galcanezumab, a humanized monoclonal antibody that selectively binds to calcitonin gene-related peptide, in the preventive treatment of chronic migraine.

Methods: A phase 3, randomized, double-blind, placebo-controlled study of LY2951742 in patients with chronic migraine (Evaluation of Galcanezumab in the Prevention of Chronic Migraine [REGAIN]) was a phase 3 study with a 3-month double-blind, placebo-controlled treatment phase and a 9-month open-label extension. Eligible patients 18 to 65 years of age with chronic migraine were randomized 2:1:1 to monthly subcutaneous injections of placebo (n = 558), galcanezumab 120 mg (with a 240-mg loading dose, n = 278), or galcanezumab 240 mg (n = 277). Read More

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November 2018
16 Reads

Assessment of Simultaneous Surgery for Odontogenic Sinusitis: Endoscopic Sinus Surgery With Endoscopic Apicoectomy.

J Craniofac Surg 2018 Nov 15. Epub 2018 Nov 15.

Department of Otolaryngology.

Odontogenic sinusitis (OS) is a disease commonly encountered by otolaryngologists and oral surgeons. There is currently no standard consensus for the management of the causative teeth of OS, and the therapeutic outcomes of endodontic surgery remain unclear. The authors herein report the outcomes of simultaneous surgery for OS, endoscopic sinus surgery (ESS) with endoscopic apicoectomy. Read More

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November 2018

Subdural empyema case report of a rare disease with a high mortality.

Rozhl Chir 2018 ;97(6):279-285

Subdural empyema is a rare purulent intracranial infection. Outcome is dependent on the preoperative level of consciousness, therefore an early diagnosis and urgent neurosurgical intervention are necessary. Mortality of subdural empyema remains high, ranging from 6% to 15%. Read More

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January 2018
6 Reads

Histopathologic Features of Chronic Sinusitis Precipitated by Odontogenic Infection.

Am J Rhinol Allergy 2018 Nov 15:1945892418811210. Epub 2018 Nov 15.

2 Rush Medical College, Rush University Medical Center, Chicago, Illinois.

Background: Chronic rhinosinusitis (CRS) is a heterogeneous disease process that can arise in the context of odontogenic disease from the maxillary teeth. The histopathologic features of odontogenic CRS (CRSo) have yet to be determined and may have important implications on disease management and need for escalation of therapy.

Objectives: The objectives of this study are to characterize the histopathologic features of CRSo and determine whether the inflammatory profile of CRSo contributes to its recalcitrance to medical therapy and need for surgery in a subset of patients with this disease. Read More

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November 2018
1 Read

Chronic sinusitis-associated antrolith.

IDCases 2018 3;14:e00467. Epub 2018 Nov 3.

VA NY Harbor Healthcare System, Brooklyn Campus, 800 Poly Place, Brooklyn, NY 11209, USA.

An antrolith is a calcified mass found in the nasal cavity or sinus, usually maxillary, described in literature as a rare phenomenon. Its presenting symptoms are variable and include symptoms associated with chronic sinusitis. We describe a 66 year old man with chronic sinusitis who presented with facial pain and epistaxis and upon further evaluation was found to have an antrolith of the left maxillary sinus. Read More

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November 2018
1 Read

IgG4-related disease in patients with idiopathic orbital inflammation syndrome: data from the French SIOI prospective cohort.

Acta Ophthalmol 2018 Nov 12. Epub 2018 Nov 12.

Service de Médecine Interne, AP-HP, Hôpital Avicenne, Bobigny, France.

Purpose: To better characterize IgG4-related disease (RD) in the setting of idiopathic orbital inflammation syndrome (IOIS).

Methods: National, multicentre, prospective, observational cohort study. Among the patients consecutively included in the French multicentre SIOI cohort, we selected those who underwent orbital and/or adnexal biopsy. Read More

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November 2018
9 Reads

Computed Tomography of Adult Rhinosinusitis.

Authors:
Katherine Ott

Radiol Technol 2018 Jul;89(6):571CT-591CT

Rhinosinusitis involves symptomatic inflammation of the paranasal sinuses. This common condition affects approximately 1 in 7 adults in the United States and is associated with significant morbidity and financial costs. Although rhinosinusitis primarily is a clinical diagnosis, medical imaging plays a unique role in sinusitis diagnosis and treatment, particularly in presurgical planning. Read More

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July 2018
1 Read

A phase 3, long-term, open-label safety study of Galcanezumab in patients with migraine.

BMC Neurol 2018 Nov 9;18(1):188. Epub 2018 Nov 9.

Eli Lilly and Company Corporate Center, Indianapolis, IN, 46285, USA.

Background: Galcanezumab, a humanized monoclonal antibody that selectively binds to the calcitonin gene-related peptide, has demonstrated in previous Phase 2 and Phase 3 clinical studies (≤6-month of treatment) a reduction in the number of migraine headache days and improved patients' functioning. This study evaluated the safety and tolerability, as well as the effectiveness of galcanezumab for up to 12 months of treatment in patients with migraine.

Methods: Patients diagnosed with episodic or chronic migraine, 18 to 65 years old, that were not exposed previously to galcanezumab, were randomized to receive galcanezumab 120 mg or 240 mg, administered subcutaneously once monthly for a year. Read More

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November 2018
3 Reads

Revisiting cefditoren for the treatment of community-acquired infections caused by human-adapted respiratory pathogens in adults.

Multidiscip Respir Med 2018 2;13:40. Epub 2018 Nov 2.

2Preventive Medicine Department, Hospital Universitario Infanta Cristina, Parla, Madrid, Spain.

Fifteen years after its licensure, this revision assesses the role of cefditoren facing the current pharmacoepidemiology of resistances in respiratory human-adapted pathogens (, , and ). In the era of post- pneumococcal conjugate vaccines and in an environment of increasing diffusion of the I gene among isolates, published studies on the cefditoren in vitro microbiological activity, pharmacokinetic/pharmcodynamic (PK/PD) activity and clinical efficacy are reviewed. Based on published data, an overall analysis is performed for PK/PD susceptibility interpretation. Read More

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November 2018
12 Reads

Ectopic teeth in the maxillary sinus: A case report and literature review.

Indian J Dent Res 2018 Sep-Oct;29(5):667-671

Department of Oolaryngology, Casa di Cura "Città di Lecco", Lecco, Italy.

Ectopic eruption of teeth is a rare phenomenon although there have been reports of teeth in the nasal septum, mandibular condyle, and maxillary sinus. This impaction can present itself in a variety of ways such as chronic or recurrent sinusitis, sepsis, and facial numbness and can also be asymptomatic. The aim of this study was to describe, by means of research literature and by a case report, the characteristics and occurrence of ectopic eruption in the maxillary sinus. Read More

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November 2018

Variation in Outpatient Antibiotic Dispensing for Respiratory Infections in Children by Clinician Specialty and Treatment Setting.

Pediatr Infect Dis J 2018 Dec;37(12):1248-1254

Medical and Clinical Pharmacy Policy, Anthem, Inc, Chicago, Illinois.

Background: Antibiotics are commonly prescribed for children with acute respiratory infections (ARIs). This study describes the distribution of ARI diagnoses and specifically quantifies antibiotic dispensing for bronchitis and upper respiratory infection (URI) by treatment setting and specialty.

Methods: This retrospective, observational cross-sectional study used data from the HealthCore Integrated Research Environment containing claims from 14 commercial health plans for 2012 to 2014. Read More

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December 2018
4 Reads

Effects of Comorbidities on Asthma Hospitalization and Mortality Rates: A Systematic Review.

Can Respir J 2018 1;2018:6460379. Epub 2018 Oct 1.

Librarian II, Eastern Health, Department of Research, St. John's, Canada.

Background: Recent studies have shown that patients diagnosed with asthma who have other chronic comorbidities have severely worse medical outcomes. However, the number of available published studies in this field is lacking. The aim of this study was to determine the effects of comorbidities in asthmatic patients based on hospitalization and mortality rates. Read More

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October 2018
7 Reads

Distinguishing the dominant species of pathogen in ethmoidal sinusitis by sequencing DNA dataset analysis.

Exp Ther Med 2018 Nov 11;16(5):4207-4212. Epub 2018 Sep 11.

Department of Otolaryngology Head and Neck Surgery, State Key Laboratory of Otolaryngology Head and Neck Surgery of Ministry of Education, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, P.R. China.

Identifying the predominant microbial species in patients with ethmoidal sinusitis is conducive to its successful treatment. The aim of the present study was to determine the microbial composition and the predominant fungal and bacterial species in patients with ethmoidal sinusitis. A sample was obtained from 3 patients with ethmoidal sinusitis and from the ethmoid sinus of 2 healthy volunteers. Read More

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November 2018
3 Reads

[Acute sinusitis in children with severe intracranial complications: two cases report].

Authors:

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Nov;32(21):1672-1673

In the past year, two cases of acute rhinosinusitis have been treated in our department. The intracranial complications of acute sinusitis in children are rare in recent years,which is associated with the low immunity of children,and the untimely treatment of acute infection.The combination of CT and MRI examination can determine the type,scope,location of intracranial complications of acute sinusitis in children with acute sinusitis. Read More

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November 2018
4 Reads