5,255 results match your criteria Sinusitis Fungal


Fungal Rhinosinusitis: Unravelling the Disease Spectrum.

Authors:
Virendra Singh

J Maxillofac Oral Surg 2019 Jun 28;18(2):164-179. Epub 2019 Jan 28.

Department of Oral and maxillofacial Surgery, PGIDS, Pt. BD Sharma University of Health Sciences, Rohtak, Haryana 124001 India.

Fungal rhinosinusitis (FRS), once considered a rare disease, has seen a steep rise in incidence in recent times. This global rise in the burden of fungal disease is a consequence of an increment in the population with weakened immune systems. Increased life expectancy with rise in conditions like diabetes mellitus, medical advancements with invasive interventions, use of immunosuppressive drugs and chemo-radiotherapy all lead to unique risk situations. Read More

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http://link.springer.com/10.1007/s12663-018-01182-w
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http://dx.doi.org/10.1007/s12663-018-01182-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441414PMC
June 2019
4 Reads

Definition and management of odontogenic maxillary sinusitis.

Authors:
Soung Min Kim

Maxillofac Plast Reconstr Surg 2019 Dec 29;41(1):13. Epub 2019 Mar 29.

Oral and Maxillofacial Microvascular Reconstruction LAB, Ghana Health Service, Brong Ahafo Regional Hospital, P.O. Box 27, Sunyani, Brong Ahafo Ghana.

Background: Maxillary sinusitis of odontogenic origin, also known as maxillary sinusitis of dental origin or odontogenic maxillary sinusitis (OMS), is a common disease in dental, otorhinolaryngologic, allergic, general, and maxillofacial contexts. Despite being a well-known disease entity, many cases are referred to otorhinolaryngologists by both doctors and dentists. Thus, early detection and initial diagnosis often fail to detect its odontogenic origin. Read More

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http://dx.doi.org/10.1186/s40902-019-0196-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439010PMC
December 2019
3 Reads

Mucor menace in an immunocompetent young male after dental manipulation.

J Family Med Prim Care 2019 Feb;8(2):757-759

Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India.

Fungal rhino-orbital sinusitis due to mucormycetes is a rapidly progressive condition with high mortality, rarely seen in immunocompetent individuals. A 26-year-old immunocompetent male presented with rhino-orbital mucormycosis after a history of dental manipulation. The patient was successfully managed with a combination of surgery, amphotericin B, and posaconazole. Read More

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http://www.jfmpc.com/text.asp?2019/8/2/757/253033
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http://dx.doi.org/10.4103/jfmpc.jfmpc_412_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436271PMC
February 2019
1 Read

Optic neuritis in an immunocompetent 40-year-old female due to fungal sphenoidal sinusitis.

GMS Ophthalmol Cases 2019 1;9:Doc06. Epub 2019 Mar 1.

Department of Glaucoma, Aravind Eye Hospital & Postgraduate Institute of Ophthalmology, Coimbatore, Tamilnadu, India.

Fungal shpenoidal sinusitis with osteomyelitis is rare in young immunocompetent patients. We present a case of a presumed fungal sphenoidal sinusitis presenting with second and sixth cranial nerve involvement which resolved well with systemic anti-fungal treatment. Read More

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http://dx.doi.org/10.3205/oc000095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436000PMC

Contemporary analysis of otolaryngic allergy.

Laryngoscope 2019 Apr 14. Epub 2019 Apr 14.

Department of Otolaryngology-Head and Neck Surgery, University of North Carolina at Chapel Hill, UNC Neuroscience Hospital, Chapel Hill, North Carolina, U.S.A.

Objectives: Investigate the current trends in otolaryngic allergy (OA).

Study Design: Cross-sectional survey.

Methods: Survey of active AAOA membership. Read More

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http://dx.doi.org/10.1002/lary.28002DOI Listing
April 2019
1 Read

Non-invasive fungal sinusitis resulting in multiple cranial nerve neuropathies.

BMJ Case Rep 2019 Apr 8;12(4). Epub 2019 Apr 8.

Department of Ear, Nose & Throat Surgery, Fiona Stanley Hospital, Murdoch, Western Australia, Australia.

A 33-year-old man presented to the emergency department with a right-sided facial paralysis and maxillary division (V2, trigeminal nerve) paraesthesia. He had been suffering with upper respiratory tract symptoms in the preceding 2 months, including rhinorrhoea, fever and headache. The patient was otherwise fit and immunocompetent. Read More

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http://dx.doi.org/10.1136/bcr-2018-229094DOI Listing
April 2019
1 Read

Cavernous sinus-orbital apex aspergillus infection in a diabetic patient: A case report.

Medicine (Baltimore) 2019 Mar;98(13):e15041

Department of Neurology, Southwest Hospital, The Third Military Medical University, Army Medical University, Chongqing, China.

Rationale: Cavernous sinus-orbital apex aspergillosis is a rare but serious complication of rhinosinusitis. Pathology results are scarce, and this condition is difficult to diagnose based on clinical and radiological results.

Patient Concerns: A 64-year-old woman presented with cavernous sinus-orbital apex syndrome. Read More

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http://dx.doi.org/10.1097/MD.0000000000015041DOI Listing
March 2019
2 Reads

Invasive Fungal Sinusitis: Risk Factors for Visual Acuity Outcomes and Mortality.

Ophthalmic Plast Reconstr Surg 2019 Mar 18. Epub 2019 Mar 18.

Department of Ophthalmology, University of California, San Francisco, San Francisco, California, U.S.A.

Purpose: Invasive fungal sinusitis is a rare but potentially lethal disease that primarily affects immunocompromised patients. The purpose of this study was to review an academic medical center's experience in the presentation, diagnosis, and treatment of invasive fungal sinusitis.

Methods: A retrospective chart review was performed at a single institution over a 17-year period. Read More

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http://dx.doi.org/10.1097/IOP.0000000000001357DOI Listing
March 2019
8 Reads

Quantitative analysis of in patients with chronic rhinosinusitis under continuous ultrasound treatment.

Iran J Microbiol 2018 Dec;10(6):354-360

Department of Medical Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Background And Objectives: Bacterial pathogens, in particular drug resistant strains, involved in chronic rhinosinusitis may result in treatment failure. Ultrasound waves are able to destroy bacterial population in sinus cavities and can recover patients.

Materials And Methods: Twelve patients with chronic sinusitis and 10 healthy controls were treated by continuous ultrasound waves. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414742PMC
December 2018
1 Read

The Role of Staphylococcus aureus in Patients with Chronic Sinusitis and Nasal Polyposis.

Curr Allergy Asthma Rep 2019 Mar 11;19(4):21. Epub 2019 Mar 11.

Department of Head and Neck Surgery, David Geffen School of Medicine, University of California Los Angeles, 10833 Le Conte Ave., CHS 62-132, Los Angeles, CA, 90095-1624, USA.

Purpose Of Review: Staphylococcus aureus (S. aureus) is correlated with the development of persistent severe inflammatory disease of the upper airway including chronic rhinosinusitis with nasal polyps (CRSwNP). The presence of S. Read More

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http://dx.doi.org/10.1007/s11882-019-0853-7DOI Listing
March 2019
9 Reads

Conversion to Chronic Invasive Fungal Sinusitis From Allergic Fungal Sinusitis in Immunocompetence.

Laryngoscope 2019 Mar 9. Epub 2019 Mar 9.

Department of Otolaryngology-Head and Neck Surgery, Augusta University, Augusta, Georgia.

A review of the treatment of allergic and invasive fungal sinusitis, as well as a presentation of the first recorded case of a conversion from allergic fungal sinusitis (AFS) to chronic granulomatous invasive sinusitis and the fourth case of invasive fungal sinusitis associated with Curvularia. This immunocompetent patient suffering from chronic AFS converted after repeated high-dose steroid tapers and noncompliance. AFS may present atypically and should be suspected even in immunocompetent patients with sinus disease who report new onset pain and neurologic symptoms. Read More

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http://doi.wiley.com/10.1002/lary.27884
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http://dx.doi.org/10.1002/lary.27884DOI Listing
March 2019
6 Reads

The Levels of Serum Biomarkers in Stable Asthma Patients with Comorbidities.

Iran J Allergy Asthma Immunol 2019 Feb;18(1):27-37

Department of Biochemistry, Adnan Menderes University Medical School, Aydın, Turkey.

The effects of comorbidities on systemic inflammation markers in stable asthmatics and the consequences of such effects have not been well evaluated. We aimed to evaluate the effect of comorbidities on clinical manifestations and systemic inflammation in asthmatic patients under control. The study group consisted of asthmatic patients who applied to our pulmonology outpatient clinic and volunteered to participate. Read More

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February 2019
4 Reads

The relationship between allergy and chronic rhinosinusitis.

Laryngoscope Investig Otolaryngol 2019 Feb 20;4(1):13-17. Epub 2018 Dec 20.

Department of Otolaryngology-Head & Neck Surgery Emory University School of Medicine Atlanta Georgia U.S.A.

Objective: To summarize the current evidence regarding a relationship between chronic rhinosinusitis (CRS) and allergy.

Methods: Literature review.

Results: Despite frequent assumption of an association between CRS and allergy the relationship between these entities remains poorly defined. Read More

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http://dx.doi.org/10.1002/lio2.236DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383312PMC
February 2019
1 Read

Orbital apex syndrome caused by Alternaria species: A novel invasive fungus and new treatment paradigm.

Orbit 2019 Mar 1:1-4. Epub 2019 Mar 1.

a Vanderbilt University Medical Center , Nashville , TN , USA.

Orbital apex syndrome as a result of invasive fungal sinusitis is a disease entity most commonly found in immunocompromised patients. Infectious invasion affecting the orbital apex can have devastating visual and life-threatening consequences. Mucormycosis and Aspergillus species are the most common causes of such infections. Read More

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http://dx.doi.org/10.1080/01676830.2019.1582071DOI Listing
March 2019
1 Read

Duration of antibiotic treatment for common infections in English primary care: cross sectional analysis and comparison with guidelines.

BMJ 2019 02 27;364:l440. Epub 2019 Feb 27.

Modelling and Economics Unit, National Infection Service, Public Health England, London NW9 5EQ, UK.

Objective: To evaluate the duration of prescriptions for antibiotic treatment for common infections in English primary care and to compare this with guideline recommendations.

Design: Cross sectional study.

Setting: General practices contributing to The Health Improvement Network database, 2013-15. Read More

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http://dx.doi.org/10.1136/bmj.l440DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391655PMC
February 2019
2 Reads

Tavaborole 5% Topical Solution for the Treatment of Toenail Onychomycosis in Pediatric Patients: Results from a Phase 4 Open-Label Study

J Drugs Dermatol 2019 Feb;18(2):190-195

Background: This study was designed to evaluate the safety, tolerability, pharmacokinetics (PK), and efficacy of tavaborole in pediatric patients. Study Design: In this open-label, single-arm study, pediatric patients (aged 6 to <17 years) with distal subungual onychomycosis affecting ≥20% of the target great toenail applied tavaborole once daily to all affected toenails (2 drops/great toenail, 1 drop/other toenail) for 48 weeks. In addition, a maximal-use subgroup (aged 12 to <17 years) applied tavaborole to all 10 toenails and ≤2 mm of surrounding skin for the first 28 days. Read More

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February 2019
1 Read

Mucormycotic Osteomyelitis Involving the Maxilla: A Rare Case Report and Review of the Literature.

Case Rep Infect Dis 2019 22;2019:8459296. Epub 2019 Jan 22.

Department of Restorative and Prosthetic Dental Sciences, Dar Al Uloom University, Riyadh, Saudi Arabia.

Osteomyelitis is an inflammatory process of bone and marrow contents. These changes in bone are primarily seen in soft tissue followed by calcified tissue. It is an opportunistic infection due to the complication of some other conditions rendering the host susceptible to disease. Read More

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http://dx.doi.org/10.1155/2019/8459296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362471PMC
January 2019

Severe facial necrosis in a type 1 diabetic patient secondary to mucormycosis masquerading as an internal maxillary artery occlusion: a case report.

BMC Infect Dis 2019 Feb 22;19(1):184. Epub 2019 Feb 22.

Alberta Health Services, Calgary, Canada.

Background: Mucormycosis is a group of rare but life threatening angioinvasive infections caused by fungi of the order Mucorales that often occurs in immunocompromised patients and individuals with poorly controlled diabetes. Rhinocerebral mucormycosis can mimic sinusitis but can rapidly progress to deeper disease and cause facial necrosis. Facial vascular thrombosis is a rare complication of mucormycosis and can confound diagnosis of the disease. Read More

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http://dx.doi.org/10.1186/s12879-019-3822-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387511PMC
February 2019
3 Reads

Successful Treatment of Sinusitis in Two Lung Transplant Recipients: Review of the Literature and Recommendations for Management.

Allergy Rhinol (Providence) 2019 Jan-Dec;10:2152656719827253. Epub 2019 Feb 5.

Department of Head and Neck Surgery, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California.

Background: fungal infection is an emerging disease which is difficult to diagnose and treat. Patients undergoing lung transplant may be colonized prior to transplantation and are at risk for lethal allograft infection after transplantation.

Objectives: To identify and evaluate treatment options. Read More

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http://dx.doi.org/10.1177/2152656719827253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376547PMC
February 2019

Endoscopic Endonasal Surgery for Sinus Fungus Balls: Clinical, Radiological, Histopathological, and Microbiological Analysis of 40 Cases and Review of the Literature.

Iran J Otorhinolaryngol 2019 Jan;31(102):35-44

Department of Otorhinolaryngology, University of Turin, San Luigi Gonzaga Hospital, Orbassano, Italy.

Introduction: Paranasal sinus fungus ball (PSFB) is a non-invasive mycosis, which appears in immunocompetent patients, along with unilateral lesion. The purpose of this study was to analyse various symptoms of PSFB and its radiological, pathological, and microbiological findings. In addition, this study involved the investigation of the incidence of bacterial coinfection and surgical techniques applied for this infection and to report the modern developments in this domain. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368987PMC
January 2019
4 Reads

Prebiotic supplementation over a cold season and during antibiotic treatment specifically modulates the gut microbiota composition of 3-6 year-old children.

Benef Microbes 2019 Apr 19;10(3):253-263. Epub 2019 Feb 19.

6 Beneo-Institute, c/o Beneo GmbH, Wormser Straβe 11, 67283 Obrigheim, Germany.

Supplementing kindergarten children during a cold season with a prebiotic inulin-type fructans product with shorter and longer fructan chains has been shown to reduce febrile episodes requiring medical attention and to lower the incidence of sinusitis. These beneficial effects may be connected to the specific modulation of children's gut microbiota. By applying quantitative and qualitative microbiota analysis this study aimed at characterising the gut microbiota composition and at exploring effects of prebiotic intervention on the gut microbiota during a 24-weeks intervention and during antibiotic treatment in healthy children. Read More

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http://dx.doi.org/10.3920/BM2018.0116DOI Listing
April 2019
3 Reads

Results of endoscopic nasal surgery in the treatment of invasive fungal sinusitis in children with cancer and immunosuppression.

Acta Otorrinolaringol Esp 2019 Feb 14. Epub 2019 Feb 14.

Departamento de Otorrinolaringología, Centro Clínico de Cabeza y Cuello, Ciudad de Guatemala, Guatemala.

Background And Objective: to describe the results of the treatment of invasive fungal sinusitis with nasal endoscopic surgery in an immunocompromised paediatric oncological population.

Methods: retrospective study of all patients diagnosed with invasive fungal sinusitis operated in the National Paediatric Oncology Unit between 2012 and 2016. Data taken from their medical history included: epidemiological characteristics, oncological diagnosis, haematological data, symptoms, tomographic studies, surgical interventions, results of pathology and cultures, medications received, complications, evolution and survival. Read More

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http://dx.doi.org/10.1016/j.otorri.2018.09.001DOI Listing
February 2019
3 Reads

Basilar occlusion and rupture secondary to rare fungal sinusitis: A case report.

World Neurosurg 2019 Feb 14. Epub 2019 Feb 14.

Lyerly Neurosurgery / Baptist Health, Baptist Neurological Institute, Jacksonville, FL.

Background: Intracranial vascular infections of fungal etiology are extremely rare. The vast majority of cases occur in immunocompromised patients with invasive fungal disease, most commonly originating in the paranasal sinuses or the lungs. An extremely rare type in this part of the world, called Granulomatous Invasive Rhinosinusitis, has been reported to affect immunocompetent patients in most cases, and its causative strain has potential to invade the intracranial arteries. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.01.179DOI Listing
February 2019
1 Read

Maxillary fungus balls due to Fusarium proliferatum.

J Mycol Med 2019 Apr 6;29(1):59-61. Epub 2019 Feb 6.

SSA, IRD, IHU - Méditerranée Infection, VITROME, Aix-Marseille Université, AP-HM, 13005 Marseille, France.

Fungus ball is the most common form of non-invasive fungal rhinosinusitis. Aspergillusfumigatus (between 44.8% and 75%) and Aspergillusflavus (14%) are the two most common species recovered. Read More

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http://dx.doi.org/10.1016/j.mycmed.2019.01.008DOI Listing
April 2019
6 Reads

Comparison of Subtyping Approaches and the Underlying Drivers of Microbial Signatures for Chronic Rhinosinusitis.

mSphere 2019 02 6;4(1). Epub 2019 Feb 6.

Department of Surgery, The University of Auckland, Auckland, New Zealand

Chronic rhinosinusitis (CRS) is a heterogeneous condition characterized by persistent sinus inflammation and microbial dysbiosis. This study aimed to identify clinically relevant subgroups of CRS patients based on distinct microbial signatures, with a comparison to the commonly used phenotypic subgrouping approach. The underlying drivers of these distinct microbial clusters were also investigated, together with associations with epithelial barrier integrity. Read More

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http://dx.doi.org/10.1128/mSphere.00679-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365615PMC
February 2019
2 Reads

[IL-25-regulated type 2 innate lymphoid cells activation promote allergic fungal rhinosinusitis].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Jan;54(1):38-45

Department of Clinical Laboratory, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.

To investigate the regulation of IL-25 on type Ⅱ innate lymphoid cells (ILC2s) activation in the pathogenesis of allergic fungal rhinosinusitis (AFRS). Nasal mucosa tissues were collected from 16 AFRS patients and 12 patients, who underwent nasal endoscopic surgery for cerebrospinal rhinorrhea or skull base benign tumor during the period from June 2016 to June 2017 in Department of Rhinology, the First Affiliated Hospital of Zhengzhou University. Firstly, flow cytometry was used to detect ILC2s in nasal mucosa of both groups. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1673-0860.2019.01.009DOI Listing
January 2019
12 Reads

The Inhibitory Effect of Essential Oils on Rhizopus stolonifer, Trichophyton mentagrophytes, and Microsporum gypseum.

Lab Med 2019 Apr;50(2):e18-e22

Winston-Salem State University, Winston-Salem, NC.

Background: Rhizopus stolonifer is an opportunistic fungus that causes respiratory infections, sinusitis, and otomycosis. Trichophyton mentagrophytes and Microsporum gypseum cause athlete's foot, ringworm, and nail infections. Previous research has shown that some essential oils inhibit fungal growth. Read More

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http://dx.doi.org/10.1093/labmed/lmy080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452308PMC

Radiographic Nuances in Allergic Fungal Rhinosinusitis.

Am J Rhinol Allergy 2019 Jan 24:1945892419825695. Epub 2019 Jan 24.

2 Division of Rhinology and Sinus Surgery, Department of Otolaryngology - Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina.

Background: Allergic fungal rhinosinusitis (AFRS) is characterized by higher revision endoscopic sinus surgery (ESS) rates and unique radiographic features when compared to chronic rhinosinusitis with nasal polyposis (CRSwNP) or chronic rhinosinusitis without nasal polyposis (CRSsNP).

Objective: We hypothesized that an increased frequency of concha bullosa in AFRS or other radiographic nuances might allow for accumulation of allergic mucin and contribute to increased ESS revision rates.

Methods: A retrospective cohort study was performed. Read More

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http://dx.doi.org/10.1177/1945892419825695DOI Listing
January 2019
6 Reads

Traditional Uses, Botany, Phytochemistry, Pharmacology, Pharmacokinetics and Toxicology of L.: A Review.

Molecules 2019 Jan 19;24(2). Epub 2019 Jan 19.

School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.

L. (Asteraceae) is a common and well-known traditional Chinese herbal medicine usually named Cang-Er-Zi, and has been used for thousands of years in China. The purpose of this paper is to summarize the progress of modern research, and provide a systematic review on the traditional usages, botany, phytochemistry, pharmacology, pharmacokinetics, and toxicology of the . Read More

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http://www.mdpi.com/1420-3049/24/2/359
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http://dx.doi.org/10.3390/molecules24020359DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359306PMC
January 2019
15 Reads
2.416 Impact Factor

Investigating the correlation between mucus cytokine levels, inflammatory cell counts, and baseline quality-of-life measures in chronic rhinosinusitis.

Int Forum Allergy Rhinol 2019 Jan 10. Epub 2019 Jan 10.

Department of Otolaryngology-Head and Neck Surgery, Vanderbilt University School of Medicine, Nashville, TN.

Background: It is hypothesized that uncontrolled inflammation is responsible for many of the manifestations and symptoms of chronic rhinosinusitis (CRS). Although earlier work has demonstrated an association between olfactory loss and mucus cytokines, the impact on other symptoms is unknown. In this study we investigated the relationship between cytokines, inflammatory cell counts, and patient-reported outcomes measures to better understand how the inflammatory microenvironment correlates with CRS symptomatology. Read More

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http://doi.wiley.com/10.1002/alr.22287
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http://dx.doi.org/10.1002/alr.22287DOI Listing
January 2019
11 Reads

Can secretory immunoglobulin A in saliva predict a change in lung infection status in patients with cystic fibrosis? A prospective pilot study.

Health Sci Rep 2018 Aug 12;1(8):e52. Epub 2018 Jul 12.

Department of Clinical Microbiology Rigshospitalet Denmark.

Background: Chronic lung infection with is the main cause of mortality in patients with cystic fibrosis (CF). Sinus colonization with P. aeruginosa often precedes intermittent lung colonization, and intermittent colonization precedes chronic infection. Read More

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http://doi.wiley.com/10.1002/hsr2.52
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http://dx.doi.org/10.1002/hsr2.52DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266372PMC
August 2018
9 Reads

Clinical pattern of fungal balls in the paranasal sinuses: our experience with 70 patients.

Eur Arch Otorhinolaryngol 2019 Apr 3;276(4):1035-1038. Epub 2019 Jan 3.

Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, South Korea.

Purpose: Many physicians recommend endoscopic sinus surgery (ESS) even when an asymptomatic paranasal sinus (PNS) fungal ball is detected incidentally. The aim of this study was to investigate the natural behavior of PNS fungal balls via sinus imaging techniques.

Methods: A follow-up study of 74 pathologically confirmed fungus balls was conducted in 70 patients who underwent multiple head and neck computed tomography (CT) scans or magnetic resonance imaging (MRI). Read More

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http://dx.doi.org/10.1007/s00405-018-5258-zDOI Listing
April 2019
2 Reads

[Logistic Regression Analysis of the Risk Factors for Multidrug-resistant Bacterial Infections in Chronic Rhinosinusitis].

Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2018 Dec;40(6):803-808

Department of Clinical Laboratory, Third Affiliated Hospital of Guizhou Medical University,Tuyun,Guizhou 558000,China.

Objective To analyze the risk factors of multidrug-resistant bacterial infections in patients with chronic rhinosinusitis.Methods The clinical data of 221 patients with chronic rhinosinusitis who were treated in our center from January 2010 to January 2017 were collected retrospectively. Specimens were collected for bacterial culture and antibiotic susceptibility testing. Read More

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http://dx.doi.org/10.3881/j.issn.1000-503X.10228DOI Listing
December 2018
3 Reads

Answer to January 2019 Photo Quiz.

J Clin Microbiol 2019 Jan 2;57(1). Epub 2019 Jan 2.

Clinical Microbiology and Parasitology Department, Hospital Universitario La Paz, Madrid, Spain.

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http://dx.doi.org/10.1128/JCM.01844-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322458PMC
January 2019

Case 40-2018: A 47-Year-Old Woman with Recurrent Sinusitis, Cough, and Bronchiectasis.

N Engl J Med 2018 Dec;379(26):2558-2565

From the Departments of Medicine (J.E.M., C.J.R.), Radiology (J.S.H.), and Pathology (L.P.H.), Massachusetts General Hospital, and the Departments of Medicine (J.E.M., C.J.R.), Radiology (J.S.H.), and Pathology (L.P.H.), Harvard Medical School - both in Boston.

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http://dx.doi.org/10.1056/NEJMcpc1810388DOI Listing
December 2018
2 Reads

Updates in management of acute invasive fungal rhinosinusitis.

Authors:
John R Craig

Curr Opin Otolaryngol Head Neck Surg 2019 Feb;27(1):29-36

Department of Otolaryngology-Head and Neck Surgery, Henry Ford Health System, Grand Blvd, Detroit, Michigan, USA.

Purpose Of Review: Acute invasive fungal rhinosinusitis (AIFRS) is a rare and often fatal disease, that remains incompletely understood. Case series and literature reviews constitute most of the literature on AIFRS, and act as the standards by which we treat these extremely complex patients. This review discusses management of AIFRS, with focuses on optimal diagnostic and therapeutic strategies. Read More

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http://dx.doi.org/10.1097/MOO.0000000000000507DOI Listing
February 2019
2 Reads

Inpatient Mortality After Endoscopic Sinus Surgery for Invasive Fungal Rhinosinusitis.

Ann Otol Rhinol Laryngol 2019 Apr 25;128(4):300-308. Epub 2018 Dec 25.

2 Division of Otolaryngology - Head and Neck Surgery, University of California, San Diego, San Diego, CA, USA.

Objectives:: Invasive fungal rhinosinusitis is a rare, life-threatening condition that affects the paranasal sinuses. The standard of care after diagnosis includes surgical debridement and aggressive medical management. Despite treatment, mortality remains unacceptably high. Read More

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http://dx.doi.org/10.1177/0003489418820871DOI Listing
April 2019
3 Reads

Measurement of Humoral Immune Competence and the Risk of Sinopulmonary Infection in a Cohort of Kidney Transplant Recipients.

Transplant Proc 2018 Dec;50(10):3367-3370

Centre for Inflammatory Diseases, School of Clinical Sciences, Monash University, Clayton, Victoria, Australia; Department of Nephrology, Monash Medical Centre, Clayton, Victoria, Australia.

Purpose: The aim of this study was to determine if measurement of B cell protective immunity was associated with susceptibility to sinopulmonary infection in kidney transplant recipients.

Methods And Materials: A prospective cohort of 168 patients with stable graft function (median 4.1 years) underwent assessment of B-lymphocyte antigen CD19 (CD19) cell number, immunoglobulin G concentration, and seroresponses to influenza vaccination upon study entry. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00411345183088
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http://dx.doi.org/10.1016/j.transproceed.2018.07.017DOI Listing
December 2018
11 Reads

Case report of Actinomyces turicensis meningitis as a complication of purulent mastoiditis.

BMC Infect Dis 2018 Dec 20;18(1):686. Epub 2018 Dec 20.

Semmelweis University, Institute of Medical Microbiology, Budapest, Hungary.

Background: Central nervous system (CNS) infections caused by Actinomyces spp. including brain abscess, actinomycoma, subdural empyema and epidural abscess are well described, however reports of Actinomyces-associated meningitis are scarcely reported.

Case Report: We present the case of a 43-year-old Hungarian male patient with poor socioeconomic status who developed acute bacterial meningitis caused by Actinomyces turicensis originating from the left side mastoiditis. Read More

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http://dx.doi.org/10.1186/s12879-018-3610-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302302PMC
December 2018
8 Reads

Fungal infections of the central nervous system and paranasal sinuses in onco-haematologic patients. Epidemiological study reporting the diagnostic-therapeutic approach and outcome in 89 cases.

Mycoses 2019 Mar 22;62(3):252-260. Epub 2019 Jan 22.

Istituto di Ematologia, Polo Onco-Ematologico Fondazione Policlinico A. Gemelli-IRCCS, Università Cattolica del Sacro Cuore, Roma, Italy.

Invasive fungal infections (IFI) of the Central Nervous System (IFI-CNS) and Paranasal Sinuses (IFI-PS) are rare, life-threatening infections in haematologic patients, and their management remains a challenge despite the availability of new diagnostic techniques and novel antifungal agents. In addition, analyses of large cohorts of patients focusing on these rare IFI are still lacking. Between January 2010 and December 2016, 89 consecutive cases of Proven (53) or Probable (36) IFI-CNS (71/89) and IFI-PS (18/89) were collected in 34 haematological centres. Read More

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http://dx.doi.org/10.1111/myc.12884DOI Listing
March 2019
4 Reads

Lung transplantation in two cystic fibrosis patients infected with previously pandrug-resistant Burkholderia cepacia complex treated with ceftazidime-avibactam.

Infection 2019 Apr 19;47(2):289-292. Epub 2018 Dec 19.

Infectious Diseases Department, Hospital Universitari Vall d'Hebron, P° Vall d'Hebron 119-129, 08035, Barcelona, Spain.

We describe two cystic fibrosis patients infected with pandrug-resistant Burkholderia cepacia complex, with the exception of ceftazidime-avibactam, who received prophylaxis with this antibiotic during lung transplantation. Although both patients had a post-operative relapse of respiratory infection, one with positive blood cultures, ceftazidime-avibactam treatment yielded a favourable outcome. 12 months after transplantation, one patient presented an excellent clinical outcome. Read More

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http://link.springer.com/10.1007/s15010-018-1261-y
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http://dx.doi.org/10.1007/s15010-018-1261-yDOI Listing
April 2019
5 Reads

Necrotic Herpes Simplex Virus Infection of the Nose and Orbit.

Ophthalmic Plast Reconstr Surg 2019 Jan/Feb;35(1):e21-e22

Department of Ophthalmology, Hamilton Eye Institute, University of Tennessee Health Science Center, Memphis, Tennessee, U.S.A.

This is the first reported case of necrotizing nasal and sinus herpes infection with orbital involvement. A 94-year-old male with a past medical history of hypertension, congestive heart failure, and chronic kidney disease presented with necrotic nasal cellulitis and a red left eye with blurry vision. Onset was 2 weeks prior with an upper lip fever blister. Read More

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http://dx.doi.org/10.1097/IOP.0000000000001288DOI Listing
December 2018
4 Reads

Mycotic Rhinitis and Sinusitis in Florida Horses.

Vet Pathol 2018 Dec 17:300985818817046. Epub 2018 Dec 17.

1 Department of Comparative, Diagnostic and Population Medicine, College of Veterinary Medicine, University of Florida, Gainesville, FL, USA.

Rhinitis and sinusitis caused by fungal pathogens were studied in biopsy samples submitted from 52 horses distributed throughout subtropical and tropical regions of Florida. Methods included routine histopathology as well as polymerase chain reaction (PCR) with panfungal/panoomycete primers and DNA sequencing on extracted DNA (DNA barcoding). Granulomatous, pyogranulomatous, and fibrinopurulent lesions in nasal and sinus mucosa were associated with signs of upper airway obstruction and noise as well as nasal discharge. Read More

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http://dx.doi.org/10.1177/0300985818817046DOI Listing
December 2018

Allergic bronchopulmonary aspergillosis successfully treated with mepolizumab: Case report and review of the literature.

Respir Med Case Rep 2019 24;26:59-62. Epub 2018 Nov 24.

Department of Respiratory Medicine, Saitama Cardiovascular and Respiratory Center, Japan.

A 56-year-old woman was referred to our hospital for recurrent asthma of 20 years duration. She was diagnosed as having allergic bronchopulmonary aspergillosis on the basis of clinical symptoms, peripheral blood eosinophilia, elevated total serum immunoglobulin E value, positive results of specific IgE and precipitating antibodies against sp., central bronchiectasis, and mucoid impaction. Read More

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http://dx.doi.org/10.1016/j.rmcr.2018.11.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6263094PMC
November 2018
10 Reads

Pediatric alternating allergic fungal rhinosinusitis: A case report and literature review.

Int J Surg Case Rep 2019 16;54:60-62. Epub 2018 Nov 16.

Consultant ENT, Rhinology and Endoscopic Skull Base Surgery at King Fahad Specialist Hospital, Dammam, Saudi Arabia.

Objectives: to report the alternating nature of allergic fungal rhinosinusitis in children in the Eastern part of Saudi Arabia and to review the experience of King Fahad Specialist Hospital in the diagnosis and management of alternating allergic fungal rhinosinusitis in children. An 8 years old Saudi girl with alternating allergic fungal rhinosinusitis was diagnosed and managed. The patient was diagnosed to have unilateral left allergic fungal rhinosinusitis and underwent endoscopic sinus surgery and cleaning of the left sinuses from polyps, mud and mucin. Read More

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http://dx.doi.org/10.1016/j.ijscr.2018.11.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289938PMC
November 2018
7 Reads

Scedosporium apiospermum invasive sinusitis presenting as extradural abscess.

Eur Ann Otorhinolaryngol Head Neck Dis 2019 Apr 4;136(2):119-121. Epub 2018 Dec 4.

Département d'otorhinolaryngologie/chirurgie cervico-faciale/chirurgie de la base du crâne, université Paris-Diderot, hôpital Lariboisière, AP-HP, Paris, France.

Introduction: Chronic invasive fungal rhinosinusitis (CIFR) is a rare entity generally observed in immunodepressed subjects. The pathogen most frequently identified is Aspergillus spp. Imaging generally reveals invasive pseudoneoplastic features. Read More

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http://dx.doi.org/10.1016/j.anorl.2018.11.009DOI Listing
April 2019
2 Reads

Current indications for balloon sinuplasty.

Curr Opin Otolaryngol Head Neck Surg 2019 Feb;27(1):7-13

Rhinology & Endoscopic Skull Base Surgery, UCLA Department of Head & Neck Surgery, Los Angeles, California, USA.

Purpose Of Review: The purpose of the review is to evaluate the current indications and contraindications for balloon sinuplasty and review the clinical trials performed in this area.

Recent Findings: The indications for balloon sinus dilatation are somewhat similar to those for endoscopic sinus surgery. Balloon sinus ostial dilation (BSD) has been found to be most effective in the treatment of recurrent acute sinusitis (RARS) and chronic rhinosinusitis without nasal polyposis (CRSsNP) that has been refractory to medical therapy. Read More

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http://dx.doi.org/10.1097/MOO.0000000000000506DOI Listing
February 2019
9 Reads

Nasal septal abscess: a 10-year retrospective study.

Eur Arch Otorhinolaryngol 2019 Feb 30;276(2):417-420. Epub 2018 Nov 30.

Department of Otolaryngology-Head and Neck Surgery, Tri-Service General Hospital, National Defense Medical Center, No. 325, Cheng-Kung Road Section 2, Taipei 114, Taiwan, ROC.

Objective: Nasal septal abscess is an uncommon condition but it can cause potentially life-threatening intracranial complications and cosmetic nasal deformity.

Methods: We analyzed ten years of cases to determine the optimal diagnostic and therapeutic modalities. A retrospective review of case notes from Tri-Service General Hospital archives was performed. Read More

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http://link.springer.com/10.1007/s00405-018-5212-0
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http://dx.doi.org/10.1007/s00405-018-5212-0DOI Listing
February 2019
16 Reads

Current understanding of allergic fungal rhinosinusitis.

World J Otorhinolaryngol Head Neck Surg 2018 Sep 9;4(3):179-185. Epub 2018 Nov 9.

McGovern Medical School at the University of Texas Health Science Center, Department of Otorhinolaryngology-Head & Neck Surgery, Houston, TX 77030, USA.

Studying the pathophysiology of allergic fungal rhinosinusitis (AFRS) has proved challenging. While this clinical entity is easily distinguishable based on the clinical criteria set forth by Bent and Kuhn twenty-five years ago, studies examining type 2 inflammatory profiles in AFRS can make it seem more alike other CRS subtypes than it is different. Still, evolving research seems to clearly delineate this subtype from others in CRS. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S20958811183012
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http://dx.doi.org/10.1016/j.wjorl.2018.08.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251961PMC
September 2018
14 Reads

Isolation of multidrug-resistant Haemophilus influenzae harbouring multiple exogenous genes from a patient diagnosed with acute sinusitis.

J Infect Chemother 2019 May 25;25(5):385-387. Epub 2018 Oct 25.

Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Japan. Electronic address:

In paediatric patients, β-lactams and macrolides are widely used to treat acute otitis media and sinusitis, which are often caused by either Streptococcus pneumoniae or Haemophilus influenzae. However, resistant isolates have emerged and are becoming more prevalent. H. Read More

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http://dx.doi.org/10.1016/j.jiac.2018.09.015DOI Listing
May 2019
3 Reads