5,716 results match your criteria Sinusitis Fungal

Infantile orbital abscess: clinical presentation, microbiological profile, and management outcomes.

Orbit 2021 May 11:1-7. Epub 2021 May 11.

Department of Orbit, Oculoplasty, Reconstructive and Aesthetics, Chennai, India.

: Orbital abscesses in children are not uncommon. Unless managed in a timely fashion, they can potentially lead to vision-threatening as well as life-threatening complications. The objective of this study is to report the clinical and microbiological profile and management outcomes in infants presenting with orbital abscesses. Read More

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Serious fungal disease incidence and prevalence in Indonesia.

Mycoses 2021 May 10. Epub 2021 May 10.

Manchester Fungal Infection Group, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom.

Background: Indonesia is a tropical country, warm and humid, with numerous environmental fungi. Data on fungal disease burden helps policy makers and clinicians.

Objectives: We have estimated the incidence and prevalence of serious fungal diseases. Read More

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Detecting serum galactomannan to diagnose acute invasive Aspergillus sinusitis: a meta-analysis.

Eur Arch Otorhinolaryngol 2021 May 6. Epub 2021 May 6.

Department of Otorhinolaryngology, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemoon-gu, Seoul, 03722, Korea.

Purpose: The serum galactomannan test has been used for diagnosing acute invasive fungal sinusitis (AIFS), especially invasive Aspergillus. We aimed to assess the accuracy of the test to diagnose acute invasive Aspergillus sinusitis (AIAS).

Methods: We searched all relevant articles published in PubMed, Embase, the Cochrane Library, and Web of Science databases up until September 14, 2020. Read More

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Microbiology of Acute Maxillary Sinusitis in Children.

Laryngoscope 2021 May 3. Epub 2021 May 3.

Department of Otolaryngology, Matsubara ENT Clinic, Gifu, Japan.

Objectives/hypothesis: Acute rhinosinusitis is a frequent common cold-related complication in children. Despite the need for appropriate treatment, its underlying microbiology remains unclear. This study aimed to investigate the microbiology of acute rhinosinusitis in children. Read More

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Diversity of cystic fibrosis chronic rhinosinusitis microbiota correlates with different pathogen dominance.

J Cyst Fibros 2021 Apr 27. Epub 2021 Apr 27.

Department of Microbiology & Immunology, University of Minnesota, USA. Electronic address:

Chronic rhinosinusitis (CRS) affects nearly all individuals with cystic fibrosis (CF) and is thought to serve as a reservoir for microbiota that subsequently colonize the lung. To better understand the microbial ecology of CRS, we generated a 16S rRNA gene sequencing profile of sinus mucus from CF-CRS patients. We show that CF-CRS sinuses harbor bacterial diversity not entirely captured by clinical culture. Read More

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Isolated Primary Sinonasal Adenocarcinoma of the Sphenoid Sinus.

Cureus 2021 Mar 26;13(3):e14127. Epub 2021 Mar 26.

Division of Neurological Surgery, University of Missouri School of Medicine, Columbia, USA.

Isolated lesions of the sphenoid sinus, particularly malignancies, are rarely reported and exist largely within the Otolaryngology literature. Delayed diagnosis may necessitate neurosurgical involvement; therefore, neurosurgeons must be aware of the range of pathologies in this region in order to provide adequate treatment. We present an unusual case of an 89-year-old female with several weeks of worsening headaches, vision loss, and cranial neuropathies. Read More

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Isavuconazole treatment of invasive fungal sinusitis: a post hoc analysis of the SECURE and VITAL trials.

Clin Infect Dis 2021 Apr 29. Epub 2021 Apr 29.

Division of Infectious Diseases, Brigham and Women's Hospital, Boston, MA.

This post-hoc analysis of international phase III isavuconazole trials identified 50 patients (90% immunocompromised or diabetic) with invasive fungal sinusitis (88% mucormycetes, Aspergillus) who received isavuconazole as primary (33) or salvage (17) therapy for median 82 days (range 2-882). Overall survival was 82% at day 42, 70% at day 84. Read More

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A "Terrible" Headache in a HIV Patient.

Ear Nose Throat J 2021 Apr 28:1455613211014106. Epub 2021 Apr 28.

1st Department of Otolaryngology-Head Neck Surgery, 37788AHEPA University Hospital, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Mucormycosis is a type of fungal infection more prevalent among immunosuppressed patients, requires prompt identification and surgical treatment, as it can is associated with local and distant spread. This case is aiming to highlight the importance of early identification of subtle symptoms in immunocompromised patients. The clinician should be aware of fungal sinusitis, consider it in the differential diagnosis, and seek for an ear, nose, and throat opinion. Read More

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Clinical utility of antifungal susceptibility testing in patients with fungal rhinosinusitis.

Indian J Med Microbiol 2021 Apr 24. Epub 2021 Apr 24.

Department of ENT, Christian Medical College, Vellore, 632004, India. Electronic address:

Purpose: To determine the association between antifungal susceptibility test (AFST) results and in vivo therapeutic response in Indian patients with fungal rhinosinusitis.

Methods: The clinicoradiological, fungal culture, AFST, histopathology results and outcomes of 48 patients with fungal rhinosinusitis seen between 20132015 were analysed. Minimum inhibitory concentration (MIC) determination was performed for amphotericin B, itraconazole, voriconazole and posaconazole. Read More

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Respiratory Disorders in Rabbits.

Vladimír Jekl

Vet Clin North Am Exot Anim Pract 2021 May;24(2):459-482

Jekl & Hauptman Veterinary Clinic, Focused on Exotic Companion Mammal Care, Mojmirovo namesti 3105/6a, Brno 61200, Czech Republic; Department of Pharmacology and Pharmacy, Faculty of Veterinary Medicine, University of Veterinary and Pharmaceutical Sciences Brno, Brno 61242, Czech Republic. Electronic address:

Respiratory disorders are very common in rabbits. Rabbits are obligate nasal breathers, so "simple" rhinitis can cause severe respiratory distress and patient collapse. Causes of dyspnea could be of primary origin or secondary, whereby diseases primarily affecting other organs can result in respiratory embarrassment even if the respiratory system is healthy (eg, anemia, cardiac disease). Read More

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Association between adenoid bacteriology and clinical characteristics of adenoid-related diseases in children.

SAGE Open Med 2021 2;9:20503121211006005. Epub 2021 Apr 2.

Office for Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Introduction: The aim of this research is to find the association between the pathogenic bacteria obtained from the adenoid culture and clinical characteristics of adenoid-related diseases in children.

Methods: In this retrospective study, we reviewed the medical records of children who had adenoidectomy for adenoid-related diseases. Demographic data, diagnoses, indications for adenoidectomy and bacterial culture results were collected. Read More

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Sinonasal teratocarcinosarcoma mimicking chronic invasive fungal disease of paranasal sinuses.

Ann R Coll Surg Engl 2021 Apr 14. Epub 2021 Apr 14.

Anesthesiology, Clinical Research Office, Ataturk University, Erzurum, Turkey.

Sinonasal teratoid carcinosarcoma or teratocarcinoma is an extremely rare aggressive tumour. It usually arises in the nasal cavity and paranasal sinuses. In this study, the authors described magnetic resonance imaging and computed tomography findings from a patient with sinonasal teratocarcinoma. Read More

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Post coronavirus disease mucormycosis: a deadly addition to the pandemic spectrum.

J Laryngol Otol 2021 Apr 8:1-6. Epub 2021 Apr 8.

Department of Otorhinolaryngology and Head Neck Surgery, Sawai Man Singh Medical College and Hospital, Jaipur, India.

Objective: To study the possible association between invasive fungal sinusitis (mucormycosis) and coronavirus disease.

Methods: A prospective observational study was conducted at a tertiary care centre over four months, involving all patients with mucormycosis of the paranasal sinuses suffering from or having a history of coronavirus disease infection.

Results: Twenty-three patients presented with mucormycosis, all had an association with coronavirus disease 2019. Read More

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Successful treatment of rhino-orbital-cerebral mucormycosis with isavuconazole salvage therapy following extensive debridement.

Med Mycol Case Rep 2021 Jun 17;32:39-42. Epub 2021 Mar 17.

Department of Ear, Nose & Throat (ENT) Surgery, Queen Elizabeth University Hospital, Glasgow, UK.

A 61-year old lady with poorly-controlled type 2 diabetes mellitus was diagnosed with rhino-orbital-cerebral mucormycosis following presentation with sinusitis, ophthalmoplegia, proptosis and facial numbness. She was treated successfully with aggressive surgical intervention including orbital exenteration, accompanied by anti-fungal therapy with liposomal amphotericin B and posaconazole, followed by isavuconazole as salvage therapy. We discuss the challenges around optimising antifungal therapy of this lethal infection in the context of hepatic and renal toxicity. Read More

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First Case of Staphylococci Carrying Linezolid Resistance Genes from Laryngological Infections in Poland.

Pathogens 2021 Mar 13;10(3). Epub 2021 Mar 13.

Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Kraków, Poland.

Linezolid is currently used to treat infections caused by multidrug-resistant Gram-positive cocci. Both linezolid-resistant (LRSA) and coagulase-negative staphylococci (CoNS) strains have been collected worldwide. Two isolates carrying linezolid resistance genes were recovered from laryngological patients and characterized by determining their antimicrobial resistance patterns and using molecular methods such as typing, MLST, SCC typing, detection of virulence genes and operon expression, and analysis of antimicrobial resistance determinants. Read More

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Perioperative Indicators of Prognosis in Acute Invasive Fungal Sinusitis.

OTO Open 2021 Jan-Mar;5(1):2473974X211002547. Epub 2021 Mar 11.

Department of Otolaryngology-Head and Neck Surgery, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.

Objective: The purpose of this study is to identify perioperative independent prognostic factors that are available to the consulting team to aid in determining prognosis in patients with acute invasive fungal sinusitis.

Study Design: Retrospective chart review of patients with biopsy-proven acute invasive fungal sinusitis from 2015 to 2018.

Setting: Academic tertiary care center. Read More

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[Analysis of clinical characteristics of fungal ball in unilateral maxillary sinus].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2021 Apr;35(4):328-332

Department of Otolaryngology Head and Neck Surgery,Qilu Hospital(Qingdao),Cheeloo College of Medicine,Shandong University,Qingdao,266035,China.

The aim of this study is to investigate the pathological characteristics of unilateralmaxillary sinus fungus ball(UMFB) in order to improve the accuracy of clinical diagnosis. A total of 86 patients with unilateral maxillary sinus lesions who underwent nasal endoscopic surgery in Qilu Hospital of Shandong University(Qingdao) from January 2017 to June 2019 were included. Those patients were confirmed UMFB or unilateral chronic maxillary sinusitis(UCMS) by pathology. Read More

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Chronic Invasive Fungal Sinusitis With Negative Histopathology: A Diagnostic Challenge.

Ear Nose Throat J 2021 Mar 30:145561320973773. Epub 2021 Mar 30.

Department of Otolaryngology-Head and Neck Surgery, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.

Although the diagnosis of chronic invasive fungal sinusitis relies chiefly on identification of invasive fungi on histology, the insidious nature of the disease can preclude detection of fungal organisms. Here, we present a case of chronic invasive fungal sinusitis with negative histopathologic findings and a definitive diagnosis made through fungal DNA detection. Clinicians should consider polymerase chain reaction an important complement to histology and culture in the diagnosis of chronic invasive fungal sinusitis. Read More

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Murine Model of Sinusitis Infection for Screening Antimicrobial and Immunomodulatory Therapies.

Front Cell Infect Microbiol 2021 12;11:621081. Epub 2021 Mar 12.

Centre for Microbial Diseases and Immunity Research, University of British Columbia, Vancouver, BC, Canada.

The very common condition of sinusitis is characterized by persistent inflammation of the nasal cavity, which contributes to chronic rhinosinusitis and morbidity of cystic fibrosis patients. Colonization by opportunistic pathogens such as and triggers inflammation that is exacerbated by defects in the innate immune response. Pathophysiological mechanisms underlying initial colonization of the sinuses are not well established. Read More

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Community-acquired Haemophilus influenzae meningitis in adults.

J Infect 2021 May 25;82(5):145-150. Epub 2021 Mar 25.

Department of Neurology, Neuroscience, University of Amsterdam, Meibergdreef, Amsterdam UMC, Amsterdam, the Netherlands. Electronic address:

Background: Haemophilus influenzae is an uncommon cause of meningitis in adults.

Methods: We analyzed episodes of community-acquired H. influenzae meningitis in adults included in a prospective nationwide cohort study in the Netherlands. Read More

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Acute invasive fungal sinusitis in immunocompromised children.

Rejin Kebudi

Hematol Transfus Cell Ther 2021 Mar 20. Epub 2021 Mar 20.

Istanbul University, Oncology Institute, Istanbul, Turkey. Electronic address:

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Usefulness of intraoperative frozen section for diagnosing acute invasive fungal rhinosinusitis: A systematic review and meta-analysis.

Int Forum Allergy Rhinol 2021 Mar 26. Epub 2021 Mar 26.

Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Bucheon St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea.

Background: The accuracy of diagnoses of acute invasive fungal rhinosinusitis (AIFRS) based on frozen sections has been questioned.

Methods: PubMed, the Cochrane Central Register of Controlled Trials, Embase, Web of Science, SCOPUS, and Google Scholar were used for data sources. True-positive, true-negative, false-positive, and false-negative data were extracted for each study. Read More

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Paranasal sinusitis at the initiation of chemotherapy is a risk factor for invasive fungal disease in children and adolescents with cancer.

Support Care Cancer 2021 Mar 22. Epub 2021 Mar 22.

Department of Hematology/Oncology for Children and Adolescents, Sapporo Hokuyu Hospital, Higashi-Sapporo 6-6, Shiroishi-ku, Sapporo, Hokkaido, 003-0006, Japan.

Background: The impact of paranasal sinusitis on the clinical outcome of patients with cancer remains unknown. The aim of this study was to determine whether paranasal sinusitis at the initiation of chemotherapy (SAI) affects the development of infectious complications in children and adolescents with cancer.

Methods: A retrospective cohort analysis of patients aged 0-20 years with cancer who received chemotherapy was performed. Read More

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Secondary infection with rhino-orbital cerebral mucormycosis associated with COVID-19.

Orbit 2021 Mar 23:1-4. Epub 2021 Mar 23.

Division of Oculofacial Plastic and Reconstructive Surgery, Viterbi Family Department of Ophthalmology, UC San Diego Shiley Eye Institute, La Jolla, California, USA.

We report two fatal cases of rhino-orbital-cerebral mucormycosis associated with COVID-19 infection. Both patients had pre-existing diabetes mellitus type 2, were treated with corticosteroids, and developed ketoacidosis. Both patients rapidly declined owing to rapid extension of the infection into the intracranial cavity. Read More

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Definition and management of invasive fungal rhinosinusitis: a single-centre retrospective study.

Acta Otorhinolaryngol Ital 2021 Feb;41(1):43-50

Department of Otolaryngology, San Luigi Gonzaga Hospital, University of Turin, Orbassano, Turin, Italy.

Objectives: The purpose of this study was to correlate acute invasive fungal rhinosinusitis (AIFRS) and chronic invasive fungal rhinosinusitis with underlying diseases, aetiological microorganisms, clinical symptoms, radiological findings, and surgical and medical treatment to determine the subset of patients who require more accurate diagnostic investigation and to prevent irreversible complications.

Methods: This retrospective monocentric study included 17 patients who underwent endoscopic sinus surgery evaluated by paranasal computed tomography and magnetic resonance imaging. Age, sex and symptoms, and location of the invasive fungal infection and the causative fungus were analysed. Read More

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February 2021

Fungal nasal septum abscess caused by complicating sinonasal surgery.

Pan Afr Med J 2020 30;36:234. Epub 2020 Jul 30.

ENT-HNS Department, Mohammed VI University Hospital Center, Marrakech, Morocco.

The fungal nasal septum abscess is a rare localized invasive form of fungal rhinosinusitis. Rare cases have been described in the literature. In this article, we intend to describe a new case of fungal nasal septum abscess caused by Aspergillus flavus in diabetic patient after sinonasal surgery. Read More

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Removal of fungal ball from the jaws by lefort i osteotomy: Difficulty in diagnosing patients with chronic sinusitis.

J Clin Exp Dent 2021 Mar 1;13(3):e318-e322. Epub 2021 Mar 1.

PhD, Professor of Oral and Maxillofacial Surgery at State University of Maringá - Maringá - PR - Brazil.

Aspergillosis, aka fungal ball (FB), is classified as a type of non-invasive fungal rhinosinusitis, which usually occurs unilaterally in the maxillary sinus of an immunocompromised patient. Its diagnosis is complex and depends on the association between clinical, imaging, and histopathological exams. There are many treatments for fungal infections of the paranasal sinuses, so early diagnosis is extremely important to determine the appropriate treatment. Read More

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Diagnostic Utility of Polymerase Chain Reaction for Paraffin-embedded Sinus Specimens for Rhinocerebral Mucormycosis Complicated by Internal Carotid Artery Thrombosis and Cerebral Infarction.

Intern Med 2021 Mar 8. Epub 2021 Mar 8.

Department of Neurology, Tokyo Women's Medical University, Japan.

We herein report a 73-year-old man who experienced cerebral infarction caused by infection with a Mucromycocetes species. A delay in anti-fungal treatment might result in a lethal clinical outcome. We were unable to establish an accurate diagnosis based on histological findings and cerebrospinal fluid culture. Read More

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Non-steroid, non-antibiotic anti-biofilm therapy for the treatment of chronic rhinosinusitis: a systematic review.

J Laryngol Otol 2021 Mar 5;135(3):196-205. Epub 2021 Mar 5.

Department of Otolaryngology-Head and Neck Surgery, Prince of Wales Hospital, Sydney, Australia.

Objective: Chronic rhinosinusitis patients with biofilms cultured from their sinonasal cavity have greater symptom burden and risk of recalcitrant disease. A number of non-antibiotic, 'anti-biofilm' treatments exist which show anti-biofilm properties in preclinical studies. There is little evidence evaluating their impact on clinical symptom scores in chronic rhinosinusitis. Read More

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