5,499 results match your criteria Sinusitis Fungal


[Modification of the method for closing the defect of the medial wall of the maxillary sinus].

Vestn Otorinolaringol 2020 ;85(2):37-40

Sverzhevsky Research Clinical Institute of Otorhinolaryngology of the Moscow Healthcare Department, Moscow, Russia.

Pathological ventilation of the maxillary sinus (MS) is one of the risk factors for the formation of chronic maxillary sinusitis.

Purpose Of Study: Is to evaluate the effectiveness of the method of restoring the medial wall of the MS with an autograft - a quadrangular cartilage of the nasal septum using the butterfly technique (Patent Application No. 2018140468, priority of 11/19/2018). Read More

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http://dx.doi.org/10.17116/otorino20208502137DOI Listing
January 2020

Fungal ball of the maxillary sinus and the risk of persistent sinus dysfunction after simple antrostomy.

Am J Otolaryngol 2020 May 8:102541. Epub 2020 May 8.

Faculty of Medicine and Health Sciences, Macquarie University, Sydney, Australia; Rhinology and Skull Base Research Group, Applied Medical Research Centre, University of New South Wales, Sydney, Australia.

Background: Maxillary sinus fungal ball is a common cause of unilateral maxillary sinusitis. Fungal balls or mycetomas are primarily treated with surgery to remove the fungus. However, this assumes the pre-fungal ball sinus cavity was normal and post-surgery patients may suffer from mucostasis in the sinus cavity with persistent symptoms. Read More

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http://dx.doi.org/10.1016/j.amjoto.2020.102541DOI Listing

Lactobacilli Have a Niche in the Human Nose.

Cell Rep 2020 May;31(8):107674

Department of Bioscience Engineering, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp, Belgium. Electronic address:

Although an increasing number of beneficial microbiome members are characterized for the human gut and vagina, beneficial microbes are underexplored for the human upper respiratory tract (URT). In this study, we demonstrate that taxa from the beneficial Lactobacillus genus complex are more prevalent in the healthy URT than in patients with chronic rhinosinusitis (CRS). Several URT-specific isolates are cultured, characterized, and further explored for their genetic and functional properties related to adaptation to the URT. Read More

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http://dx.doi.org/10.1016/j.celrep.2020.107674DOI Listing

Non-Aspergillus invasive mold infections in patients treated with ibrutinib.

Mycoses 2020 May 27. Epub 2020 May 27.

Department of Infectious Diseases, Infection Control, and Employee Health, MD , Anderson Cancer Center, University of Texas Houston, Houston, Texas, USA.

Background: Invasive mold infections (IMIs) are very rare in patients with lymphoid malignancies. However, IMIs, mostly due to Aspergillus species, have been increasingly reported in such patients receiving ibrutinib (IBR). There is paucity of information regarding non-Aspergillus invasive mold infections (NAIMIs) in this setting, OBJECTIVES: To review our experience the published literature on the topic. Read More

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http://dx.doi.org/10.1111/myc.13120DOI Listing

Facial Reconstruction Based on Combined Three-Dimensional Printing and Microsurgical Free Transfer.

J Craniofac Surg 2020 May 19. Epub 2020 May 19.

Department of Plastic and Reconstructive Surgery and Burn Unit, Centro Hospitalar de São João, Porto Medical School, Alameda Professor Hernâni Monteiro, Porto, Portugal.

There are patients with craniofacial deformity that can lead to extensive bone loss and severe disfigurement. Autologous reconstruction may be challenging in these patients, and it is usually associated with flap donor area morbidity and unfavorable aesthetic and functional results. A 51-year-old patient with human immunodeficiency virus infection, developed in the context of immunosuppression a fulminant fungal rhino-sinusitis with the need for surgical debridement, and in consequence extensive destruction of the nasal cavity and upper jaw, resulting in severe disfigurement due to nasal deformity and maxillary collapse. Read More

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http://dx.doi.org/10.1097/SCS.0000000000006559DOI Listing

Orbital cellulitis, sinusitis and intracranial abnormalities in two adolescents with COVID-19.

Orbit 2020 May 18:1-6. Epub 2020 May 18.

Department of Radiology, Rutgers New Jersey Medical School, Newark, New Jersey, USA.

We review two cases of adolescents with orbital cellulitis, sinusitis and SARS- CoV-2 infection presenting to emergency departments within a 24 hour period. SARS-CoV-2 samples obtained within 24 hours were positive, supporting prior infection despite relatively limited early symptoms of COVID-19. Unusual clinical and radiographic characteristics included hemorrhagic abscess with blood of varying age in the first, intracranial epidural abscess in the second, radiographic signal consistent with hemorrhagic or thrombotic phenomena, retro-maxillary antral fat changes, and meningeal enhancement or extension in both cases. Read More

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http://dx.doi.org/10.1080/01676830.2020.1768560DOI Listing

[Radicality of maxillary sinus surgery and size of the maxillary sinus ostium].

HNO 2020 May 13. Epub 2020 May 13.

Klinik für Hals-Nasen-Ohrenheilkunde, Kopf- und Halschirurgie, Universitätsklinikum Ulm, Frauensteige 12, 89075, Ulm, Deutschland.

Until the 1990s, radical sinus surgery was considered a standard procedure for maxillary sinus diseases, but it is no longer favored due to the high morbidity. Today, functional endoscopic sinus surgery (FESS) is considered the gold standard in sinus surgery. Modifications of surgical approaches also allow access to regions of the maxillary sinus that were previously difficult to reach. Read More

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http://dx.doi.org/10.1007/s00106-020-00870-9DOI Listing

Fungal Rhinosinusitis: Prevalence and Spectrum in Singapore.

Cureus 2020 Apr 8;12(4):e7587. Epub 2020 Apr 8.

Otolaryngology, Tan Tock Seng Hospital, Singapore, SGP.

Background Fungal involvement of the paranasal sinuses has been described more than two centuries ago. In the current article, it is referred to as fungal rhinosinusitis (FRS) which is a general term that is used to describe a spectrum of pathologically, immunologically, and clinically different disease entities affecting the paranasal sinuses where fungus is thought to be the major potential etiology. Objective To determine the incidence and spectrum of FRS in Singapore and to compare our findings with international figures through literature review. Read More

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http://dx.doi.org/10.7759/cureus.7587DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212715PMC

A Case Report of Maxillary Aspergillosis with Unusual Clinical and Imaging Presentations.

J Contemp Dent Pract 2020 Feb 1;21(2):211-214. Epub 2020 Feb 1.

Department of Oral Diagnostic Sciences, Faculty of Dentistry, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia, Phone: +966-254-0000, e-mail:

Aim: The aim of the present study was to present a case of maxillary aspergillosis with unusual clinical presentation and imaging findings.

Background: The range of lesions and conditions that affect the maxillary sinus is wide and vast. This necessitates a dynamic multidisciplinary approach for proper diagnosis and effective management. Read More

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February 2020

[Fungal sinus infection by Schizophyllum commune: Report of two clinical cases].

Rev Iberoam Micol 2020 May 3. Epub 2020 May 3.

Servicio de Microbiología, Hospital Universitario de La Princesa, Madrid, España; Instituto de Investigación Sanitaria La Princesa, Madrid, España.

Background: Schizophyllum commune is a basidiomycete fungus which is widely distributed in nature. Its role as responsible for disease in humans is not well known, partly due to its difficult identification. The incorporation of mass spectrometry techniques (MALDI-TOF) and molecular biology to the laboratories has allowed the description of a greater number of cases. Read More

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http://dx.doi.org/10.1016/j.riam.2020.02.004DOI Listing

Fungal Pneumonia in The Immunocompetent Host: A Possible Statistical Connection Between Allergic Fungal Sinusitis with Polyposis and Recurrent Pulmonary Infection Detected by Gastroesophageal Reflux Disease Scintigraphy.

Mol Imaging Radionucl Ther 2020 Apr;29(2):72-78

University of Notre Dame, CNI Molecular Imaging, Sydney, Australia.

Objectives: Fungal pneumonia in the immune competent host is a rarity with few reported cases in the literature. We present a series of 7 cases of recurrent fungal pneumonia in association with allergic fungal rhinosinusitis and gastroesophageal reflux disease (GERD). We hypothesised that recurrent infection may have been transported from the infected paranasal sinuses into the lung by GERD as the process was terminated by surgical fundoplication in 2 of these patients. Read More

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http://dx.doi.org/10.4274/mirt.galenos.2020.32154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201431PMC

Extramedullary Hematopoiesis in the Sinonasal Cavity: A Case Report and Review of the Literature.

Allergy Rhinol (Providence) 2020 Jan-Dec;11:2152656720918874. Epub 2020 Apr 21.

Department of Otolaryngology-Head and Neck Surgery, University of North Carolina, Chapel Hill, North Carolina.

Background: Extramedullary hematopoiesis (EMH) occurs in patients with hematologic disorders, but rarely within the paranasal sinuses. We report a case of EMH in a 17-year-old male with sickle cell disease (SCD) who presented with occipital pain and sinusitis. A computed tomography (CT) scan demonstrated heterogeneous opacification of the right maxillary sinus concerning for allergic fungal sinusitis or a fungal ball with bony erosion. Read More

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http://dx.doi.org/10.1177/2152656720918874DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7177988PMC

sphenoidal sinusitis as presentation of a non-Hodgkin Lymphoma.

Med Mycol Case Rep 2020 Jun 6;28:26-28. Epub 2020 Apr 6.

Infectious Diseases Department, Centro Hospitalar Universitário São João, Alameda Hernâni Monteiro, 4200-319, Porto, Portugal.

is a basidiomycetes worldwide distributed that has emerged as cause of invasive infections in immunosuppressed patients. We present a case of a man who was simultaneously diagnosed with a small cell non-Hodgkin lymphoma and a sphenoid sinusitis by . Intraoperative observation and histology description were crucial to consider an alternative diagnosis to mucormycosis suggested by the MRI. Read More

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http://dx.doi.org/10.1016/j.mmcr.2020.04.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7162964PMC

Infectious laryngotracheitis: Etiology, epidemiology, pathobiology, and advances in diagnosis and control - a comprehensive review.

Vet Q 2020 Dec;40(1):140-161

Department of Microbiology & Immunology, Department of Pediatrics, Division of Hematology, Oncology and Bone Marrow Transplantation, University of Miami School of Medicine, Miami, Florida, USA.

Infectious laryngotracheitis (ILT) is a highly contagious upper respiratory tract disease of chicken caused by a Gallid herpesvirus 1 (GaHV-1) belonging to the genus and subfamily within family. The disease is characterized by conjunctivitis, sinusitis, oculo-nasal discharge, respiratory distress, bloody mucus, swollen orbital sinuses, high morbidity, considerable mortality and decreased egg production. It is well established in highly dense poultry producing areas of the world due to characteristic latency and carrier status of the virus. Read More

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http://dx.doi.org/10.1080/01652176.2020.1759845DOI Listing
December 2020
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Does the Change in the Indications of Endoscopic Sinonasal Surgery Continue? Data between 1994-2018.

Turk Arch Otorhinolaryngol 2020 Mar 1;58(1):5-9. Epub 2020 Mar 1.

Department of Otorhinolaryngology, University of Health Sciences Ankara Numune Training and Research Hospital, Ankara, Turkey.

Objective: Endoscopic sinonasal surgery (ESS) has changing over the years in parallel with the developments in endoscopy devices, video-imaging techniques, and surgical instruments. In the present study we investigated whether the indications of patients who underwent surgery over a period of 25 years have accommodated to these changes.

Methods: We retrospectively evaluated 1173 patients who underwent surgery in our clinic from 1994 through 2007, and 954 patients who underwent surgery from 2008 through 2018. Read More

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http://dx.doi.org/10.5152/tao.2020.4828DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7162596PMC

Impact of a Multifaceted Antimicrobial Stewardship Intervention in a Primary Health Care Area: A Quasi-Experimental Study.

Front Pharmacol 2020 2;11:398. Epub 2020 Apr 2.

Medicine Department, Universitat Internacional de Catalunya, Barcelona, Spain.

The aim of the study was to evaluate the impact of a multifaceted antimicrobial stewardship intervention on antibiotic consumption in a primary health care (PHC) area in Spain. Quasi-experimental study conducted in a PHC area with nine PHC centers, a 400-bed acute care teaching hospital, and 18 nursing homes serving a population of 260,561. The intervention was based on the 2016 CDC Core Elements of Outpatient Antibiotic Stewardship publication and targeted 130 PHC physicians, 41 PHC pediatricians, 19 emergency physicians, and 18 nursing home physicians. Read More

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http://dx.doi.org/10.3389/fphar.2020.00398DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7142248PMC

Allergic Fungal rhino-sinusitis frequency in chronic rhino-sinusitis patients and accuracy of fungal culture in its diagnosis.

Pak J Med Sci 2020 Mar-Apr;36(3):555-558

Dr. Samina Qamar, FCPS. Department of Pathology, King Edward Medical University/Mayo Hospital, Lahore, Pakistan.

Objective: To determine the frequency of Allergic Fungal Rhino-sinusitis (AFRS) in Chronic Rhino-sinusitis (CRS) patients and the accuracy of fungal culture in diagnosing AFRS.

Methods: Immunocompetent patients with CRS and without invasive fungal rhino-sinusitis presenting over a period of 3 years in ENT department of Mayo Hospital, from April 2014 to September 2017 were included in the study. AFRS was diagnosed clinically and on Bent and Kuhn diagnostic criteria. Read More

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http://dx.doi.org/10.12669/pjms.36.3.1661DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7150416PMC

A multi-institutional review of outcomes in biopsy-proven chronic invasive fungal sinusitis.

Int Forum Allergy Rhinol 2020 Jun 13;10(6):738-747. Epub 2020 Apr 13.

Department of Otolaryngology, University of Washington, Seattle, WA.

Background: Chronic invasive fungal sinusitis (CIFS) is a rare, life-threatening infection of the nose and sinuses. This study aims to identify factors that impact survival in 1 of the largest cohorts to date.

Methods: Pathology records were reviewed for biopsy-proven CIFS from 3 tertiary academic institutions from 1995 to 2016. Read More

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http://dx.doi.org/10.1002/alr.22547DOI Listing

Current Concepts in the Management of Allergic Fungal Rhinosinusitis.

Immunol Allergy Clin North Am 2020 05 29;40(2):345-359. Epub 2020 Jan 29.

Department of Otorhinolaryngology-Head & Neck Surgery, McGovern Medical School at the University of Texas Health Science Center, Texas Sinus Institute, 6431 Fannin Street, MSB 5.036, Houston, TX 77030, USA; Center for Immunology and Autoimmune Diseases, Institute of Molecular Medicine, McGovern Medical School at the University of Texas Health Science Center, Houston, TX, USA. Electronic address:

Allergic fungal rhinosinusitis (AFRS) represents a subtype of chronic rhinosinusitis with nasal polyposis that exhibits a unique, often striking clinical presentation. Since its initial description more than a quarter century ago, a more sophisticated understanding of the pathophysiology of AFRS has been achieved and significant advancements in improving clinical outcomes made. This review focuses on the latest developments involving the pathophysiology and clinical management of this fascinating disease. Read More

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http://dx.doi.org/10.1016/j.iac.2019.12.001DOI Listing

The Microbiome and Chronic Rhinosinusitis.

Immunol Allergy Clin North Am 2020 05 16;40(2):251-263. Epub 2020 Jan 16.

Department of Otolaryngology-Head and Neck Surgery, University of Colorado, 12631 East 17th Avenue, B205, Aurora, CO 80045, USA. Electronic address:

Chronic rhinosinusitis (CRS) is persistent inflammation and/or infection of the nasal cavity and paranasal sinuses. Recent advancements in culture-independent molecular techniques have enhanced understanding of interactions between sinus microbiota and upper airway microenvironment. The dysbiosis hypothesis-alteration of microbiota associated with perturbation of the local ecological landscape-is suggested as a mechanism involved in CRS pathogenesis. Read More

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http://dx.doi.org/10.1016/j.iac.2019.12.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7154041PMC

The Role of Allergic Rhinitis in Chronic Rhinosinusitis.

Immunol Allergy Clin North Am 2020 05 14;40(2):201-214. Epub 2020 Jan 14.

Department of Otolaryngology, Emory University, Medical Office Tower (MOT), 11th Floor, 550 Peachtree Street Northeast, Atlanta, GA 30308, USA. Electronic address:

This literature review collates and summarizes recent literature to explore the relationship between chronic rhinosinusitis (CRS) and allergy. The relationship between CRS and allergy is not fully understood. However, current evidence suggests a relationship between allergy and specific endotypes of CRS with nasal polyposis, including allergic fungal rhinosinusitis and central compartment atopic disease. Read More

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http://dx.doi.org/10.1016/j.iac.2019.12.010DOI Listing

Our evolving understanding of the pathogenesis and presentations of chronic rhinosinusitis: Implications for therapeutic options.

Ann Allergy Asthma Immunol 2020 04;124(4):303-304

Department of Medicine, Asthma and Allergic Disease Center, University of Virginia Health Systems, Charlottesville, Virginia; Department of Microbiology, Asthma and Allergic Disease Center, University of Virginia Health Systems, Charlottesville, Virginia. Electronic address:

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http://dx.doi.org/10.1016/j.anai.2020.02.005DOI Listing

Isolated Sphenoid Sinus Inflammatory Disease-A Report of 14 Cases.

Iran J Otorhinolaryngol 2020 Mar;32(109):101-107

Department of Otolaryngology, San Luigi Gonzaga Hospital, University of Turin, Orbassano, Italy.

Introduction: Isolated sphenoid sinus inflammatory diseases (ISSIDs) are responsible for about 75% of isolated sphenoid sinus opacifications. Computer tomography (CT) and magnetic resonance imaging (MRI) should be used in a complementary manner for the assessment of ISSIDs. This evaluation sheds some light on the extent of disease and intracranial and intra-orbital involvement. Read More

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http://dx.doi.org/10.22038/ijorl.2019.39416.2304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7085922PMC

[MORAXELLA OSLOENSIS BACTEREMIA WITH PNEUMONIA: FIRST REPORTED CASE IN ISRAEL].

Harefuah 2020 Mar;159(3):163-165

Galilee Medical Center, Department of Internal Medicine "D", Nahariya.

Introduction: Community acquired pneumonia (CAP), an acute infection of the pulmonary parenchyma acquired in the community, is generally treated in an outpatient setting and involves different etiological agents. In the adult community, the most common pathogen in the disease is Streptococcus pneumonia, though other multiple etiological agents (atypical) have been involved, including Mycoplasma pneumoniae, Chlamydophila pneumoniae, and Legionella pneumophila. The genus Moraxella consists of aerobic, oxidase-positive gram-negative coccobacilli. Read More

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Mucormycosis creeping along the nerves in an immunocompetent individual.

J Radiol Case Rep 2019 Oct 31;13(10):1-10. Epub 2019 Oct 31.

Department of Radiodiagnosis, B J Govt. Medical College & Sassoon General Hospitals, Pune, India.

Mucormycosis is a rare opportunistic fungal infection, often life-threatening. We report an unusual case of rhinocerebral mucormycosis in an immunocompetent patient. A 23-year-old male presented with headache, speech disturbance and hearing difficulty for 4 weeks. Read More

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http://dx.doi.org/10.3941/jrcr.v13i10.3671DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7060009PMC
October 2019

Indications and Outcomes for Patients With Limited Symptoms Undergoing Endoscopic Sinus Surgery.

Am J Rhinol Allergy 2020 Jul 13;34(4):502-507. Epub 2020 Mar 13.

Division of Rhinology, Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Palo Alto, California.

Background: Previous research have suggested that chronic rhinosinusitis (CRS) patients with lower symptomatic scores, demonstrated by a 22-item Sinonasal Outcome Test (SNOT-22) score <20, may not achieve meaningful quality of life improvement following endoscopic sinus surgery (ESS). However, indications for ESS are continuing to be defined and many low SNOT-22 scoring patients still undergo elective surgery for CRS and other benign sinonasal pathologies. The outcomes for these patients have not been previously studied. Read More

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http://dx.doi.org/10.1177/1945892420912159DOI Listing

Multicenter evaluation of the QIAstat Respiratory Panel-A new rapid highly multiplexed PCR based assay for diagnosis of acute respiratory tract infections.

PLoS One 2020 12;15(3):e0230183. Epub 2020 Mar 12.

Department of Clinical Microbiology, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark.

Acute respiratory tract infections (ARTI), including the common cold, pharyngitis, sinusitis, otitis media, bronchiolitis and pneumonia are the most common diagnoses among patients seeking medical care in western countries, and account for most antibiotic prescriptions. While a confirmed and fast ARTI diagnosis is key for antibiotic prescribing, empiric antimicrobial treatment remains common, because viral symptoms are often clinically similar and difficult to distinguish from those caused by bacteria. As a result, inappropriate antibiotic prescriptions are high and in certain settings likely higher than the commonly estimated 30%. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0230183PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067435PMC

A Study on the Prevalence and Clinical Features of Fungal Sinusitis in Chronic Rhinosinusitis.

Indian J Otolaryngol Head Neck Surg 2020 Mar 5;72(1):117-122. Epub 2019 Dec 5.

Department of ENT, Head and Neck Surgery, JSS Academy of Higher Education and Research, Mysuru, Karnataka India.

Chronic sinusitis is a common disorder worldwide a significant proportion of which is secondary to fungal aetiology contrary to popular belief that fungal sinusitis is a rare entity, more so in a country like India where warm moist climate in a number of states and ever rising incidence of diabetes mellitus gives the fungal organisms a perfect environment to grow. This study aims to find the incidence and clinical features of fungal rhinosinusitis in chronic rhinosinusitis reinstating the fact that it should be kept as a differential diagnosis in every patient presenting with symptoms of chronic rhinosinusitis. Aim of the study was to find out the incidence and clinical manifestations of fungal sinusitis in chronic rhinosinusitis. Read More

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http://dx.doi.org/10.1007/s12070-019-01769-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7040144PMC

First Case of Invasive Stachybotrys Sinusitis.

Clin Infect Dis 2020 Mar 10. Epub 2020 Mar 10.

Department of Molecular Imaging and Therapy, Diabetes and Metabolism Research Institute, Beckman Research Institute, Duarte, California, USA.

Background: The toxigenic mold Stachybotrys has controversially been linked to idiopathic pulmonary hemorrhage and "sick building syndrome". However, there are no previous clinical records of invasive stachybotryosis.

Methods: Sinus biopsy specimens from a 23-year old male with refractory acute lymphocytic leukemia were obtained at three different time points during the patient's hospitalization (139 days) and examined by histopathology and immunohistochemistry (IHC). Read More

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http://dx.doi.org/10.1093/cid/ciaa231DOI Listing

Successful allogeneic stem cell transplantation in a case with acute myeloid leukemia and invasive Schizophyllum commune rhinosinusitis.

J Infect Chemother 2020 May 5;26(5):506-509. Epub 2020 Mar 5.

Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.

Schizophyllum commune, a basidiomycete fungus, is a quite rare cause of invasive sinusitis for which no standard treatment has yet been established. We report herein a 59-year-old woman who developed S. commune rhinosinusitis after remission induction chemotherapy for her acute myeloid leukemia. Read More

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http://dx.doi.org/10.1016/j.jiac.2019.12.013DOI Listing

Avoiding repeated surgery in patients with acute invasive fungal sinusitis.

Eur Arch Otorhinolaryngol 2020 Jun 3;277(6):1667-1674. Epub 2020 Mar 3.

Department of ENT (Rhinology and Anterior Skull Base Unit), Christian Medical College, Vellore, 632004, India.

Purpose: We aimed to ascertain whether using an aggressive initial surgical protocol would reduce the need for repeated sinus surgery in patients with acute invasive fungal sinusitis (AIFS).

Methods: Patients with AIFS prospectively underwent clinicoradiological assessment followed by bilateral functional endoscopic sinus surgery (FESS) and debridement of affected tissue. Antifungal therapy was also administered. Read More

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http://dx.doi.org/10.1007/s00405-020-05879-yDOI Listing

Granulomatous invasive fungal sinusitis.

Ci Ji Yi Xue Za Zhi 2020 Jan-Mar;32(1):96. Epub 2019 Sep 30.

Department of Pathology, PK Das Institute of Medical Sciences, Ottapalam, Kerala, India.

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http://dx.doi.org/10.4103/tcmj.tcmj_173_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7015006PMC
September 2019

Surgical outcomes of the endonasal endoscopic approach within a standardized management protocol for repair of spontaneous cerebrospinal fluid rhinorrhea.

J Neurosurg 2020 Feb 28:1-7. Epub 2020 Feb 28.

Departments of1Neurological Surgery and.

Objective: Spontaneous CSF leaks are rare, their diagnosis is often delayed, and they can precipitate meningitis. Craniotomy is the historical "gold standard" repair for these leaks. An endonasal endoscopic approach (EEA) offers potentially less invasiveness and lower surgical morbidity than a traditional craniotomy but must yield the same surgical success. Read More

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http://dx.doi.org/10.3171/2019.12.JNS192891DOI Listing
February 2020

Molecular identification of species complex isolated from clinical samples and its antifungal susceptibility patterns.

Curr Med Mycol 2019 ;5(4):43-49

Department of Microbiology, Government Medical College Hospital, Chandigarh, India.

Background And Purpose: More than 300 species are grouped into approximately 23 species complexes out of which around 70 are involved in human infections. The nomenclature of these species has undergone considerable changes in recent years. These species cause localized infections in individuals while inducing systemic infections mainly in immunocompromised patients. Read More

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http://dx.doi.org/10.18502/cmm.5.4.2149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034782PMC
January 2019

Microinvasive Fungal Rhinosinusitis: Proposal of a New Subtype in the Classification.

J Clin Med 2020 Feb 24;9(2). Epub 2020 Feb 24.

Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea.

Background: Fungal rhinosinusitis (FRS) with mucosal invasion is not classified by the current criteria, and clinical reports on the topic are limited. The aim of this study was to present our 25-year experience on fungal balls with mucosal invasion that do not appear in the FRS classification.

Methods: Of 1318 patients who underwent endoscopic surgery with paranasal FRS between November 1994 and July 2019, 372 underwent mucosal biopsies. Read More

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http://dx.doi.org/10.3390/jcm9020600DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7074386PMC
February 2020

Gonorrhea-positive sinus cultures in a 15-year-old with allergic fungal sinusitis.

JAAPA 2020 Mar;33(3):31-33

Kimberly Donner practices pediatric otolaryngology at Children's Medical Center in Dallas, Tex. Yann-Fuu Kou is a pediatric otolaryngology fellow at Cincinnati (Ohio) Children's Hospital and a previous resident in the Department of Otolaryngology, Head and Neck Surgery at the University of Texas Southwestern Medical Center in Dallas. Anna Tomkies is a resident in the Department of Otolaryngology, Head and Neck Surgery at the University of Texas Southwestern Medical Center. Dinesh Rakheja is a professor of pathology at University of Texas Southwestern Medical Center in Dallas. Ron B. Mitchell is a professor and vice chairman of the Department of Otolaryngology, Head and Neck Surgery at the University of Texas Southwestern Medical Center and chief of pediatric otolaryngology at Children's Medical Center. Gopi Shah is an assistant professor in the Department of Otolaryngology, Head and Neck Surgery at the University of Texas Southwestern Medical Center. The authors have disclosed no potential conflicts of interest, financial or otherwise.

This article describes a patient with gonorrhea in sinus cultures and allergic fungal sinusitis. A multidisciplinary team was assembled to deliver the results to the minor patient and her family and provide support and resources for long-term care. Read More

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http://dx.doi.org/10.1097/01.JAA.0000654388.09692.8aDOI Listing

Characteristics of the Airway Microbiome of Cystic Fibrosis Patients.

Biochemistry (Mosc) 2020 Jan;85(1):1-10

Gamaleya National Research Center for Epidemiology and Microbiology, Ministry of Health of Russia, Moscow, 123098, Russia.

Microbiota as an integral component of human body is actively investigated, including by massively parallel sequencing. However, microbiomes of lungs and sinuses have become the object of scientific attention only in the last decade. For patients with cystic fibrosis, monitoring the state of respiratory tract microorganisms is essential for maintaining lung function. Read More

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http://dx.doi.org/10.1134/S0006297920010010DOI Listing
January 2020

Chronic Granulomatous Invasive Fungal Sinusitis: A Case Series and Literature Review.

Ear Nose Throat J 2020 Feb 20:145561320904620. Epub 2020 Feb 20.

Department of Otolaryngology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

Chronic granulomatous invasive fungal sinusitis (CGIFS) is a peculiar disease of the paranasal sinuses due to its rarity, patient subset, and disease course. We describe 7 cases of histopathologically confirmed CGIFS with different treatment plans and varying outcomes. Of particular note was that one of these patients developed allergic fungal rhinosinusitis after complete resolution of his primary invasive disease, a finding that has never been reported in the literature. Read More

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http://dx.doi.org/10.1177/0145561320904620DOI Listing
February 2020

Histopathological analysis of sinonasal lesions associated with chronic rhinosinusitis and comparison with computed tomography diagnoses.

Pak J Med Sci 2020 Jan-Feb;36(2):146-150

Dr. Kamal Dahhan Alsultan, PhD. Department of Diagnostic Radiology Technology, College of Applied Medical Sciences, Taibah University, Almadinah Almunawwarah, Kingdom of Saudi Arabia.

Background &objective: Chronic rhino sinusitis (CRS) is an inflammatory condition of the paranasal sinuses and the nasal passage lasting more than three months either with or without sinonasal polyps. This study aimed to report the common sinonasal lesions associated with CRS according to the histopathology results, to compare between clinical and histopathological diagnoses, and to compare between radiological and histopathological diagnoses of the sinonasal lesions.

Methods: A retrospective study of the electronic records of 82 patients diagnosed with CRS with nasal polyps. Read More

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http://dx.doi.org/10.12669/pjms.36.2.1453DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6994869PMC
February 2020

Binding of pDNA with cDNA using hybridization strategy towards monitoring of Haemophilus influenza genome in human plasma samples.

Int J Biol Macromol 2020 May 10;150:218-227. Epub 2020 Feb 10.

Department of Nanotechnology, Faculty of Science and Chemistry, Urmia University, Urmia, Iran. Electronic address:

Haemophilus Influenza leads to respiratory infections such as sinusitis, acute otitis media, pneumonia and bronchitis. In addition, it causes invasive infections such as cellulite, septic arthritis, and meningitis. Therefore, quick and sensitive detection of H. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2020.02.062DOI Listing

Skull base osteomyelitis: clinical and radiologic analysis of a rare and multifaceted pathological entity.

Neurosurg Rev 2020 Feb 8. Epub 2020 Feb 8.

Unit of Otorhinolaryngology - Head and Neck Surgery, University of Brescia, Brescia, Italy.

Skull base osteomyelitis (SBO) is a potentially life-threatening inflammation of cranial base bony structures of variable origin. Criteria for diagnosis and treatment are still controversial. Demographics, predisposing factors, symptoms, imaging, and clinical, laboratory, histological, and microbiological data of patients managed for SBO at the University Hospital of Brescia (ASST Spedali Civili) between 2002 and 2017 were retrospectively reviewed. Read More

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http://dx.doi.org/10.1007/s10143-020-01254-xDOI Listing
February 2020

High PI3K/mTOR and low MAPK/JNK activity results in decreased apoptosis and autophagy in nasal polyposis.

Braz J Otorhinolaryngol 2020 Jan 15. Epub 2020 Jan 15.

Izmir Katip Celebi University, Atatürk Training and Research Hospital, Department of Otorhinolaryngology, Izmir, Turkey.

Introduction: Nasal polyposis is a progressive inflammatory disease that reduces the quality of life. The role - of apoptotic and autophagic pathways in nasal polyposis pathogenesis is not yet clearly known.

Objective: In this study we aimed to investigate apoptotic (MAPK/JNK), anti-apoptotic (PI3K/mTOR) and autophagic (LC3) pathways which are related each other in the nasal polyposis tissues. Read More

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http://dx.doi.org/10.1016/j.bjorl.2019.12.005DOI Listing
January 2020

ADRENAL INSUFFICIENCY CAUSED BY PARACOCCIDIOIDOMYCOSIS: THREE CASE REPORTS AND REVIEW.

AACE Clin Case Rep 2019 Jul-Aug;5(4):e238-e243. Epub 2019 Mar 13.

Objective: Fungal infections can affect the adrenal glands, causing primary adrenal insufficiency (PAI). Although endemic to South America, paracoccidioidomycosis (PCM), which can lead to PAI, has gained global relevance with the increase in international travel and migration.

Methods: The present report describes 3 patients with PAI caused by PCM. Read More

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http://dx.doi.org/10.4158/ACCR-2018-0632DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6873835PMC

Prevalence of fungal infection in nasal polyposis - A cross-sectional study, conducted at a tertiary care hospital in Karachi.

J Pak Med Assoc 2020 Jan;70(1):48-52

Department of Pathology, Sahara Medical College, Narowal, Pakistan.

Objective: To determine the prevalence of fungal infections causing nasal polyposis (AFRS-Allergic fungal rhino sinusitis) in the local population.

Methods: It is a cross sectional study, carried out from October 2010 to January 2015 on 221 patients in the ENT Department of Abbasi Shaheed Hospital and Karachi Medical & Dental College in collaboration with the microbiology department. This study included patients who had a clinical diagnosis of nasal polyposis with or without fungal infection on the basis of nasoendoscopic examinations. Read More

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http://dx.doi.org/10.5455/JPMA.296507DOI Listing
January 2020
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MR Findings of Fungus Ball: Significance of High Signal Intensity on T1-Weighted Images.

J Korean Med Sci 2020 Jan 20;35(3):e22. Epub 2020 Jan 20.

Department of Radiology, Seoul National University Hospital Healthcare System Gangnam Center, Seoul National University College of Medicine, Seoul, Korea.

Background: Central dark-signal intensity with high-signal, hypertrophic mucosal wall of paranasal sinuses on T2-weighted images (T2WI) is a characteristic magnetic resonance imaging (MRI) feature of sinonasal fungus ball. However, this finding is usually interpreted as non-fungal chronic sinusitis with central normal sinus air. In addition, T1-weighted images (T1WI) and T2WI are basic sequences of all magnetic resonance (MR) examinations. Read More

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http://dx.doi.org/10.3346/jkms.2020.35.e22DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6970076PMC
January 2020

DERMATITIS AND RHINOSINUITIS CAUSED BY SPECIES IN A CHINESE GORAL ().

J Zoo Wildl Med 2020 Jan;50(4):1008-1011

The Wilds, Cumberland, OH 43732, USA.

Curvularia spp. are globally distributed saprophytic fungi, classified in the literature as dematiaceous, or darkly pigmented fungi. These fungi have been increasingly recognized as causing cutaneous, ocular, respiratory, and central nervous system infections in humans, but have been infrequently documented as pathogens in the veterinary literature. Read More

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http://dx.doi.org/10.1638/2018-0013DOI Listing
January 2020

The impact of Lactococcus lactis (probiotic nasal rinse) co-culture on growth of patient-derived strains of Pseudomonas aeruginosa.

Int Forum Allergy Rhinol 2020 Apr 10;10(4):444-449. Epub 2020 Jan 10.

Department of Otolaryngology-Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, AL.

Background: The Lactococcus strain of bacteria has been introduced as a probiotic nasal rinse for alleged salubrious effects on the sinonasal bacterial microbiome. However, data regarding interactions with pathogenic bacteria within the sinuses are lacking. The purpose of this study is to assess the interaction between L. Read More

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http://dx.doi.org/10.1002/alr.22521DOI Listing

Type 2 inflammation suppression by T-regulatory cells attenuates the eosinophil recruitment in mucosa of chronic sinusitis.

Clin Sci (Lond) 2020 Jan;134(2):123-138

Department of Otolaryngology-Head and Neck Surgery, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.

Type 2 inflammation and eosinophilic infiltration are prominent pathologic features of chronic rhinosinusitis with nasal polyps (CRSwNP). The purpose of the present study was to determine the roles of Tregs in controlling type 2 inflammation and inhibiting eosinophilic infiltration in CRSwNP. A total of 134 nasal polyps, 67 ostiomeatal complex from chronic rhinosinusitis (CRS) and 62 normal nasal tissues from controls were collected to study the enumeration and function of Tregs cells and the expressions of cytokine profiles via immunofluorescence staining, flow cytometry, qRT-PCR, ELISA, and/or H&E staining. Read More

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http://dx.doi.org/10.1042/CS20190388DOI Listing
January 2020

An Open-Label Pilot Study of Adrenocorticotrophic Hormone in the Treatment of IgA Nephropathy at High Risk of Progression.

Kidney Int Rep 2020 Jan 31;5(1):58-65. Epub 2019 Oct 31.

Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, USA.

Introduction: IgA nephropathy (IgAN) is the most common glomerulonephritis with high risk of progression to end-stage renal disease in patients with proteinuria >1 g/24 hours. There are no known effective treatments in patients with IgAN.

Methods: We conducted a prospective open-label pilot study in patients with IgAN using adrenocorticotrophic hormone (ACTH) (Acthar Gel, Mallinckrodt Pharmaceuticals, Bedminster, NJ) at a dosage of 80 units subcutaneously twice weekly for a total of 6 months and followed patients for a total of 12 months. Read More

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http://dx.doi.org/10.1016/j.ekir.2019.10.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943772PMC
January 2020

Invasive pseudomembranous upper airway and tracheal Aspergillosis refractory to systemic antifungal therapy and serial surgical debridement in an Immunocompetent patient.

BMC Infect Dis 2020 Jan 6;20(1):13. Epub 2020 Jan 6.

Department of Internal Medicine, Yale Infectious Diseases, Yale School of Medicine, PO Box 208022, New Haven, CT, 06520, USA.

Background: The development of respiratory infections secondary to Aspergillus spp. spores found ubiquitously in the ambient environment is uncommon in immunocompetent patients. Previous reports of invasive upper airway aspergillosis in immunocompetent patients have generally demonstrated the efficacy of treatment regimens utilizing antifungal agents in combination with periodic endoscopic debridement, with symptoms typically resolving within months of initiating therapy. Read More

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http://dx.doi.org/10.1186/s12879-019-4744-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6945574PMC
January 2020