5,216 results match your criteria Sinusitis Fungal


Basilar occlusion and rupture secondary to rare fungal sinusitis: A case report.

World Neurosurg 2019 Feb 14. Epub 2019 Feb 14.

Lyerly Neurosurgery / Baptist Health, Baptist Neurological Institute, Jacksonville, FL.

Background: Intracranial vascular infections of fungal etiology are extremely rare. The vast majority of cases occur in immunocompromised patients with invasive fungal disease, most commonly originating in the paranasal sinuses or the lungs. An extremely rare type in this part of the world, called Granulomatous Invasive Rhinosinusitis, has been reported to affect immunocompetent patients in most cases, and its causative strain has potential to invade the intracranial arteries. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.01.179DOI Listing
February 2019

Maxillary fungus balls due to Fusarium proliferatum.

J Mycol Med 2019 Feb 6. Epub 2019 Feb 6.

SSA, IRD, IHU - Méditerranée Infection, VITROME, Aix-Marseille Université, AP-HM, 13005 Marseille, France.

Fungus ball is the most common form of non-invasive fungal rhinosinusitis. Aspergillusfumigatus (between 44.8% and 75%) and Aspergillusflavus (14%) are the two most common species recovered. Read More

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http://dx.doi.org/10.1016/j.mycmed.2019.01.008DOI Listing
February 2019
1 Read

[IL-25-regulated type 2 innate lymphoid cells activation promote allergic fungal rhinosinusitis].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Jan;54(1):38-45

Department of Clinical Laboratory, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.

To investigate the regulation of IL-25 on type Ⅱ innate lymphoid cells (ILC2s) activation in the pathogenesis of allergic fungal rhinosinusitis (AFRS). Nasal mucosa tissues were collected from 16 AFRS patients and 12 patients, who underwent nasal endoscopic surgery for cerebrospinal rhinorrhea or skull base benign tumor during the period from June 2016 to June 2017 in Department of Rhinology, the First Affiliated Hospital of Zhengzhou University. Firstly, flow cytometry was used to detect ILC2s in nasal mucosa of both groups. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1673-0860.2019.01.009DOI Listing
January 2019
3 Reads

The Inhibitory Effect of Essential Oils on Rhizopus stolonifer, Trichophyton mentagrophytes, and Microsporum gypseum.

Lab Med 2019 Jan 28. Epub 2019 Jan 28.

Winston-Salem State University, Winston-Salem, NC.

Background: Rhizopus stolonifer is an opportunistic fungus that causes respiratory infections, sinusitis, and otomycosis. Trichophyton mentagrophytes and Microsporum gypseum cause athlete's foot, ringworm, and nail infections. Previous research has shown that some essential oils inhibit fungal growth. Read More

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http://dx.doi.org/10.1093/labmed/lmy080DOI Listing
January 2019

Radiographic Nuances in Allergic Fungal Rhinosinusitis.

Am J Rhinol Allergy 2019 Jan 24:1945892419825695. Epub 2019 Jan 24.

2 Division of Rhinology and Sinus Surgery, Department of Otolaryngology - Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina.

Background: Allergic fungal rhinosinusitis (AFRS) is characterized by higher revision endoscopic sinus surgery (ESS) rates and unique radiographic features when compared to chronic rhinosinusitis with nasal polyposis (CRSwNP) or chronic rhinosinusitis without nasal polyposis (CRSsNP).

Objective: We hypothesized that an increased frequency of concha bullosa in AFRS or other radiographic nuances might allow for accumulation of allergic mucin and contribute to increased ESS revision rates.

Methods: A retrospective cohort study was performed. Read More

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http://dx.doi.org/10.1177/1945892419825695DOI Listing
January 2019
1 Read

Traditional Uses, Botany, Phytochemistry, Pharmacology, Pharmacokinetics and Toxicology of L.: A Review.

Molecules 2019 Jan 19;24(2). Epub 2019 Jan 19.

School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.

L. (Asteraceae) is a common and well-known traditional Chinese herbal medicine usually named Cang-Er-Zi, and has been used for thousands of years in China. The purpose of this paper is to summarize the progress of modern research, and provide a systematic review on the traditional usages, botany, phytochemistry, pharmacology, pharmacokinetics, and toxicology of the . Read More

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http://www.mdpi.com/1420-3049/24/2/359
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http://dx.doi.org/10.3390/molecules24020359DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359306PMC
January 2019
6 Reads
2.416 Impact Factor

Investigating the correlation between mucus cytokine levels, inflammatory cell counts, and baseline quality-of-life measures in chronic rhinosinusitis.

Int Forum Allergy Rhinol 2019 Jan 10. Epub 2019 Jan 10.

Department of Otolaryngology-Head and Neck Surgery, Vanderbilt University School of Medicine, Nashville, TN.

Background: It is hypothesized that uncontrolled inflammation is responsible for many of the manifestations and symptoms of chronic rhinosinusitis (CRS). Although earlier work has demonstrated an association between olfactory loss and mucus cytokines, the impact on other symptoms is unknown. In this study we investigated the relationship between cytokines, inflammatory cell counts, and patient-reported outcomes measures to better understand how the inflammatory microenvironment correlates with CRS symptomatology. Read More

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http://doi.wiley.com/10.1002/alr.22287
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http://dx.doi.org/10.1002/alr.22287DOI Listing
January 2019
3 Reads

Can secretory immunoglobulin A in saliva predict a change in lung infection status in patients with cystic fibrosis? A prospective pilot study.

Health Sci Rep 2018 Aug 12;1(8):e52. Epub 2018 Jul 12.

Department of Clinical Microbiology Rigshospitalet Denmark.

Background: Chronic lung infection with is the main cause of mortality in patients with cystic fibrosis (CF). Sinus colonization with P. aeruginosa often precedes intermittent lung colonization, and intermittent colonization precedes chronic infection. Read More

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http://doi.wiley.com/10.1002/hsr2.52
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http://dx.doi.org/10.1002/hsr2.52DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266372PMC
August 2018
3 Reads

Clinical pattern of fungal balls in the paranasal sinuses: our experience with 70 patients.

Eur Arch Otorhinolaryngol 2019 Jan 3. Epub 2019 Jan 3.

Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, South Korea.

Purpose: Many physicians recommend endoscopic sinus surgery (ESS) even when an asymptomatic paranasal sinus (PNS) fungal ball is detected incidentally. The aim of this study was to investigate the natural behavior of PNS fungal balls via sinus imaging techniques.

Methods: A follow-up study of 74 pathologically confirmed fungus balls was conducted in 70 patients who underwent multiple head and neck computed tomography (CT) scans or magnetic resonance imaging (MRI). Read More

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http://dx.doi.org/10.1007/s00405-018-5258-zDOI Listing
January 2019

Answer to January 2019 Photo Quiz.

J Clin Microbiol 2019 Jan 2;57(1). Epub 2019 Jan 2.

Clinical Microbiology and Parasitology Department, Hospital Universitario La Paz, Madrid, Spain.

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http://dx.doi.org/10.1128/JCM.01844-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322458PMC
January 2019

Case 40-2018: A 47-Year-Old Woman with Recurrent Sinusitis, Cough, and Bronchiectasis.

N Engl J Med 2018 Dec;379(26):2558-2565

From the Departments of Medicine (J.E.M., C.J.R.), Radiology (J.S.H.), and Pathology (L.P.H.), Massachusetts General Hospital, and the Departments of Medicine (J.E.M., C.J.R.), Radiology (J.S.H.), and Pathology (L.P.H.), Harvard Medical School - both in Boston.

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http://dx.doi.org/10.1056/NEJMcpc1810388DOI Listing
December 2018
2 Reads

Updates in management of acute invasive fungal rhinosinusitis.

Authors:
John R Craig

Curr Opin Otolaryngol Head Neck Surg 2019 Feb;27(1):29-36

Department of Otolaryngology-Head and Neck Surgery, Henry Ford Health System, Grand Blvd, Detroit, Michigan, USA.

Purpose Of Review: Acute invasive fungal rhinosinusitis (AIFRS) is a rare and often fatal disease, that remains incompletely understood. Case series and literature reviews constitute most of the literature on AIFRS, and act as the standards by which we treat these extremely complex patients. This review discusses management of AIFRS, with focuses on optimal diagnostic and therapeutic strategies. Read More

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http://dx.doi.org/10.1097/MOO.0000000000000507DOI Listing
February 2019
1 Read

Measurement of Humoral Immune Competence and the Risk of Sinopulmonary Infection in a Cohort of Kidney Transplant Recipients.

Transplant Proc 2018 Dec;50(10):3367-3370

Centre for Inflammatory Diseases, School of Clinical Sciences, Monash University, Clayton, Victoria, Australia; Department of Nephrology, Monash Medical Centre, Clayton, Victoria, Australia.

Purpose: The aim of this study was to determine if measurement of B cell protective immunity was associated with susceptibility to sinopulmonary infection in kidney transplant recipients.

Methods And Materials: A prospective cohort of 168 patients with stable graft function (median 4.1 years) underwent assessment of B-lymphocyte antigen CD19 (CD19) cell number, immunoglobulin G concentration, and seroresponses to influenza vaccination upon study entry. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00411345183088
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http://dx.doi.org/10.1016/j.transproceed.2018.07.017DOI Listing
December 2018
7 Reads

Case report of Actinomyces turicensis meningitis as a complication of purulent mastoiditis.

BMC Infect Dis 2018 Dec 20;18(1):686. Epub 2018 Dec 20.

Semmelweis University, Institute of Medical Microbiology, Budapest, Hungary.

Background: Central nervous system (CNS) infections caused by Actinomyces spp. including brain abscess, actinomycoma, subdural empyema and epidural abscess are well described, however reports of Actinomyces-associated meningitis are scarcely reported.

Case Report: We present the case of a 43-year-old Hungarian male patient with poor socioeconomic status who developed acute bacterial meningitis caused by Actinomyces turicensis originating from the left side mastoiditis. Read More

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http://dx.doi.org/10.1186/s12879-018-3610-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302302PMC
December 2018
5 Reads

Lung transplantation in two cystic fibrosis patients infected with previously pandrug-resistant Burkholderia cepacia complex treated with ceftazidime-avibactam.

Infection 2018 Dec 19. Epub 2018 Dec 19.

Infectious Diseases Department, Hospital Universitari Vall d'Hebron, P° Vall d'Hebron 119-129, 08035, Barcelona, Spain.

We describe two cystic fibrosis patients infected with pandrug-resistant Burkholderia cepacia complex, with the exception of ceftazidime-avibactam, who received prophylaxis with this antibiotic during lung transplantation. Although both patients had a post-operative relapse of respiratory infection, one with positive blood cultures, ceftazidime-avibactam treatment yielded a favourable outcome. 12 months after transplantation, one patient presented an excellent clinical outcome. Read More

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http://link.springer.com/10.1007/s15010-018-1261-y
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http://dx.doi.org/10.1007/s15010-018-1261-yDOI Listing
December 2018
3 Reads

Necrotic Herpes Simplex Virus Infection of the Nose and Orbit.

Ophthalmic Plast Reconstr Surg 2019 Jan/Feb;35(1):e21-e22

Department of Ophthalmology, Hamilton Eye Institute, University of Tennessee Health Science Center, Memphis, Tennessee, U.S.A.

This is the first reported case of necrotizing nasal and sinus herpes infection with orbital involvement. A 94-year-old male with a past medical history of hypertension, congestive heart failure, and chronic kidney disease presented with necrotic nasal cellulitis and a red left eye with blurry vision. Onset was 2 weeks prior with an upper lip fever blister. Read More

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http://dx.doi.org/10.1097/IOP.0000000000001288DOI Listing
December 2018
3 Reads

Mycotic Rhinitis and Sinusitis in Florida Horses.

Vet Pathol 2018 Dec 17:300985818817046. Epub 2018 Dec 17.

1 Department of Comparative, Diagnostic and Population Medicine, College of Veterinary Medicine, University of Florida, Gainesville, FL, USA.

Rhinitis and sinusitis caused by fungal pathogens were studied in biopsy samples submitted from 52 horses distributed throughout subtropical and tropical regions of Florida. Methods included routine histopathology as well as polymerase chain reaction (PCR) with panfungal/panoomycete primers and DNA sequencing on extracted DNA (DNA barcoding). Granulomatous, pyogranulomatous, and fibrinopurulent lesions in nasal and sinus mucosa were associated with signs of upper airway obstruction and noise as well as nasal discharge. Read More

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http://dx.doi.org/10.1177/0300985818817046DOI Listing
December 2018

Allergic bronchopulmonary aspergillosis successfully treated with mepolizumab: Case report and review of the literature.

Respir Med Case Rep 2019 24;26:59-62. Epub 2018 Nov 24.

Department of Respiratory Medicine, Saitama Cardiovascular and Respiratory Center, Japan.

A 56-year-old woman was referred to our hospital for recurrent asthma of 20 years duration. She was diagnosed as having allergic bronchopulmonary aspergillosis on the basis of clinical symptoms, peripheral blood eosinophilia, elevated total serum immunoglobulin E value, positive results of specific IgE and precipitating antibodies against sp., central bronchiectasis, and mucoid impaction. Read More

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http://dx.doi.org/10.1016/j.rmcr.2018.11.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6263094PMC
November 2018
9 Reads

Pediatric alternating allergic fungal rhinosinusitis: A case report and literature review.

Int J Surg Case Rep 2019 16;54:60-62. Epub 2018 Nov 16.

Consultant ENT, Rhinology and Endoscopic Skull Base Surgery at King Fahad Specialist Hospital, Dammam, Saudi Arabia.

Objectives: to report the alternating nature of allergic fungal rhinosinusitis in children in the Eastern part of Saudi Arabia and to review the experience of King Fahad Specialist Hospital in the diagnosis and management of alternating allergic fungal rhinosinusitis in children. An 8 years old Saudi girl with alternating allergic fungal rhinosinusitis was diagnosed and managed. The patient was diagnosed to have unilateral left allergic fungal rhinosinusitis and underwent endoscopic sinus surgery and cleaning of the left sinuses from polyps, mud and mucin. Read More

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http://dx.doi.org/10.1016/j.ijscr.2018.11.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289938PMC
November 2018
5 Reads

Scedosporium apiospermum invasive sinusitis presenting as extradural abscess.

Eur Ann Otorhinolaryngol Head Neck Dis 2018 Dec 4. Epub 2018 Dec 4.

Département d'otorhinolaryngologie/chirurgie cervico-faciale/chirurgie de la base du crâne, université Paris-Diderot, hôpital Lariboisière, AP-HP, Paris, France.

Introduction: Chronic invasive fungal rhinosinusitis (CIFR) is a rare entity generally observed in immunodepressed subjects. The pathogen most frequently identified is Aspergillus spp. Imaging generally reveals invasive pseudoneoplastic features. Read More

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http://dx.doi.org/10.1016/j.anorl.2018.11.009DOI Listing
December 2018
1 Read

Current indications for balloon sinuplasty.

Curr Opin Otolaryngol Head Neck Surg 2019 Feb;27(1):7-13

Rhinology & Endoscopic Skull Base Surgery, UCLA Department of Head & Neck Surgery, Los Angeles, California, USA.

Purpose Of Review: The purpose of the review is to evaluate the current indications and contraindications for balloon sinuplasty and review the clinical trials performed in this area.

Recent Findings: The indications for balloon sinus dilatation are somewhat similar to those for endoscopic sinus surgery. Balloon sinus ostial dilation (BSD) has been found to be most effective in the treatment of recurrent acute sinusitis (RARS) and chronic rhinosinusitis without nasal polyposis (CRSsNP) that has been refractory to medical therapy. Read More

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http://dx.doi.org/10.1097/MOO.0000000000000506DOI Listing
February 2019
4 Reads

Current understanding of allergic fungal rhinosinusitis.

World J Otorhinolaryngol Head Neck Surg 2018 Sep 9;4(3):179-185. Epub 2018 Nov 9.

McGovern Medical School at the University of Texas Health Science Center, Department of Otorhinolaryngology-Head & Neck Surgery, Houston, TX 77030, USA.

Studying the pathophysiology of allergic fungal rhinosinusitis (AFRS) has proved challenging. While this clinical entity is easily distinguishable based on the clinical criteria set forth by Bent and Kuhn twenty-five years ago, studies examining type 2 inflammatory profiles in AFRS can make it seem more alike other CRS subtypes than it is different. Still, evolving research seems to clearly delineate this subtype from others in CRS. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S20958811183012
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http://dx.doi.org/10.1016/j.wjorl.2018.08.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251961PMC
September 2018
7 Reads

Isolation of multidrug-resistant Haemophilus influenzae harbouring multiple exogenous genes from a patient diagnosed with acute sinusitis.

J Infect Chemother 2018 Oct 25. Epub 2018 Oct 25.

Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Japan. Electronic address:

In paediatric patients, β-lactams and macrolides are widely used to treat acute otitis media and sinusitis, which are often caused by either Streptococcus pneumoniae or Haemophilus influenzae. However, resistant isolates have emerged and are becoming more prevalent. H. Read More

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http://dx.doi.org/10.1016/j.jiac.2018.09.015DOI Listing
October 2018
2 Reads

The Microbiology of Complicated Acute Sinusitis among Pediatric Patients: A Case Series.

Otolaryngol Head Neck Surg 2018 Nov 27:194599818815109. Epub 2018 Nov 27.

3 Division of Otolaryngology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.

Objective: The microbiology of pediatric complicated acute rhinosinusitis (ARS) has evolved, and our current understanding of pathogenic organisms is limited. The objectives of this study are to describe the incidence of pathogens causing complicated ARS requiring surgical intervention at our institution over a 10-year period as well as their associated treatment outcomes.

Study Design: Retrospective cohort study. Read More

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http://journals.sagepub.com/doi/10.1177/0194599818815109
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http://dx.doi.org/10.1177/0194599818815109DOI Listing
November 2018
7 Reads

Histoplasma capsulatum causing sinusitis: a case report in French Guiana and review of the literature.

BMC Infect Dis 2018 Nov 26;18(1):595. Epub 2018 Nov 26.

AcademicLaboratory of Parasitology and Mycology, Andrée Rosemon Hospital, 97306, Cayenne, French Guiana.

Background: American histoplasmosis is a mycosis caused by Histoplasma capsulatum. A variety of clinical features of histoplasmosis have been commonly described ranging from asymptomatic infections to severe pulmonary infections. In immunocompromised individuals, progressive disseminated forms are frequent, leading to fatal outcome if untreated. Read More

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http://dx.doi.org/10.1186/s12879-018-3499-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258161PMC
November 2018
1 Read

In vitro analysis of growth patterns of invasive fungal species on commonly used endonasal hemostatic agents.

Am J Otolaryngol 2019 Jan - Feb;40(1):101-105. Epub 2018 Sep 25.

Department of Otolaryngology-Head and Neck Surgery, Augusta University, 1120 15th Street, BP-4109, Augusta, GA 30912, United States of America.

Objective: Previous studies have not examined the potential role of endonasal hemostatic agents in facilitating growth of fungal species. We aim to determine the possibility of these to serve as a nutrient source for fungal growth.

Methods: Cultures of Aspergillus, Fusarium, and Mucor were harvested and placed in solution in sterile saline at standardized high and low concentrations. Read More

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http://dx.doi.org/10.1016/j.amjoto.2018.09.016DOI Listing
September 2018
2 Reads

Sinusitis Update.

Emerg Med Clin North Am 2019 Feb;37(1):41-54

Department of Emergency Medicine, Division of International EM Stony Brook University (SUNY), 101 Nicholls Road, HSC Level 4, Stony Brook, NY 11794, USA.

Rhinosinusitis affects many pediatric patients as well as 1 in 6 adults in any given year, resulting in ambulatory care, pediatric, and emergency department visits. Uncomplicated rhinosinusitis requires no imaging or testing and does not require antibiotic treatment. Using strict clinical diagnostic criteria may minimize unnecessary antibiotics. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07338627183009
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http://dx.doi.org/10.1016/j.emc.2018.09.007DOI Listing
February 2019
15 Reads

Fungus Ball of the Maxillary Sinus-Modern Treatment by Osteoplastic Approach and Functional Endoscopic Sinus Surgery.

J Oral Maxillofac Surg 2018 Oct 24. Epub 2018 Oct 24.

Department Head, Department of Oral and Maxillofacial Surgery, University Hospital Tuebingen, Tuebingen, Germany.

Purpose: Functional endoscopic sinus surgery (FESS) is considered standard surgical therapy for fungus ball of the maxillary sinus. However, recent findings have indicated an odontogenic etiology, which requires simultaneous treatment of the dental origin. This study presents the authors' treatment results of fungus ball of the maxillary sinus using a combination of FESS and an endoscopically assisted osteoplastic approach through the anterior wall of the maxillary sinus, enabling simultaneous treatment of the dental origin. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02782391183118
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http://dx.doi.org/10.1016/j.joms.2018.10.010DOI Listing
October 2018
10 Reads

Distinguishing the dominant species of pathogen in ethmoidal sinusitis by sequencing DNA dataset analysis.

Exp Ther Med 2018 Nov 11;16(5):4207-4212. Epub 2018 Sep 11.

Department of Otolaryngology Head and Neck Surgery, State Key Laboratory of Otolaryngology Head and Neck Surgery of Ministry of Education, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, P.R. China.

Identifying the predominant microbial species in patients with ethmoidal sinusitis is conducive to its successful treatment. The aim of the present study was to determine the microbial composition and the predominant fungal and bacterial species in patients with ethmoidal sinusitis. A sample was obtained from 3 patients with ethmoidal sinusitis and from the ethmoid sinus of 2 healthy volunteers. Read More

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http://www.spandidos-publications.com/10.3892/etm.2018.6726
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http://dx.doi.org/10.3892/etm.2018.6726DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200977PMC
November 2018
8 Reads

Predictive ability of bedside nasal endoscopy to diagnose invasive fungal sinusitis in a pediatric population.

Int J Pediatr Otorhinolaryngol 2018 Dec 19;115:82-88. Epub 2018 Sep 19.

Division of Otolaryngology, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.

Introduction: Invasive fungal sinusitis (IFS) is a rare but deadly clinical entity that occurs in immunocompromised patients. Diagnosis in children typically requires operative biopsies under general anesthesia, which has associated risks. Findings on bedside nasal endoscopy (BNE) can be used with history, exam, and imaging to determine the need for surgery, however, the accuracy of this tool has not been established among pediatric patients. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01655876183047
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http://dx.doi.org/10.1016/j.ijporl.2018.09.019DOI Listing
December 2018
17 Reads

From prevention to optimal treatment in chronic rhinosinusitis.

Authors:
P W Hellings

Rhinology 2018 Dec;56(4):305-306

Laboratory of Clinical Immunology, Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium, Euforea, Brussels, Belgium.

Prevention of chronic rhinosinusitis remains a true societal challenge, as prevention of this highly prevalent non-communicable disease will significantly reduce socio-economic costs and improve the overall well-being of the large group of affected individuals. In alignment with the health priorities of national governments, prevention and cost-effective health care should be embraced by the Rhinologic community. Read More

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http://dx.doi.org/10.4193/Rhin18.404DOI Listing
December 2018
10 Reads

Isolated fungus ball in sphenoid sinus: tips and pitfalls of hyperintense lesions.

BJR Case Rep 2018 10;4(2):20170081. Epub 2018 Jan 10.

Department of Hemathology and Medical Oncology, Unit of Pathology, Ospedale Casa Sollievo della Sofferenza, San Giovanni Rotondo, Puglia, Italy.

Isolated sphenoid sinus fungus ball is a very rare condition. CT is the most used imaging investigation for diagnosis. In some cases, MRI may provide further information to evaluate the extracompartmental invasion. Read More

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http://dx.doi.org/10.1259/bjrcr.20170081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6159120PMC
January 2018

Rhinosinusitis in Solid Organ Transplant Recipients: Analysis of 4562 Transplanted Patients.

Am J Rhinol Allergy 2018 Oct 26:1945892418808717. Epub 2018 Oct 26.

1 Department of Otolaryngology, Head and Neck Surgery, Rabin Medical Center, Petah Tikva, Israel.

Introduction: Survival rates of solid organ transplant recipients are steadily increasing. Chronic immunosuppression is a key to sustain the transplanted organ. Thus, these patients are at a higher risk for fulminant disease and severe complications of rhinosinusitis (RS). Read More

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http://journals.sagepub.com/doi/10.1177/1945892418808717
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http://dx.doi.org/10.1177/1945892418808717DOI Listing
October 2018
11 Reads

The role of galactomannan Aspergillus antigen in diagnosing acute invasive fungal sinusitis.

Int Forum Allergy Rhinol 2019 Jan 25;9(1):60-66. Epub 2018 Oct 25.

Department of Otolaryngology, Wake Forest Baptist Medical Center, Winston Salem, NC.

Background: Pathologic diagnosis remains the gold standard for final diagnosis of acute invasive fungal sinusitis (AIFS); however, other less invasive tests could suggest the presence of AIFS in at-risk populations where early diagnosis is crucial. Serum galactomannan Aspergillus antigen has been shown to correlate with a diagnosis of invasive pulmonary aspergillosis; however, it has not adequately been evaluated in regard to AIFS. The objective of this study is to evaluate the statistical relevance of galactomannan in predicting diagnosis of AIFS. Read More

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http://doi.wiley.com/10.1002/alr.22225
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http://dx.doi.org/10.1002/alr.22225DOI Listing
January 2019
15 Reads

New tools for preoperative diagnosis of allergic fungal sinusitis? A prospective study about 71 patients.

Clin Otolaryngol 2019 Jan 25;44(1):91-96. Epub 2018 Nov 25.

Department of Oto-Rhino-Laryngology - Head and Neck Surgery, Aix-Marseille Univ, APHM, CNRS, IUSTI, Conception, Marseille, France.

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http://doi.wiley.com/10.1111/coa.13243
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http://dx.doi.org/10.1111/coa.13243DOI Listing
January 2019
20 Reads

Chronic Rhinosinusitis-Could Phenotyping or Endotyping Aid Therapy?

Am J Rhinol Allergy 2018 Oct 24:1945892418807590. Epub 2018 Oct 24.

4 Royal Brompton and Harefield Hospitals NHS Foundation Trust, London, UK.

Objectives: We reviewed the phenotyping and endotyping of chronic rhinosinusitis (CRS) and treatment options.

Methods: We searched PubMed, Google, Google Scholar, and the Proquest Central Database of the Kırıkkale University Library.

Results: Phenotypes are observable properties of an organism produced by the environment acting upon the genotype, that is, patients with a particular disorder are subgrouped according to common characteristics. Read More

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http://dx.doi.org/10.1177/1945892418807590DOI Listing
October 2018
5 Reads

Exserohilum infections in Australian Queensland children.

Mycoses 2019 Feb 6;62(2):181-185. Epub 2018 Nov 6.

Infection Management and Prevention Service, Queensland Children's Hospital, Brisbane, Queensland, Australia.

Background: Exserohilum species are environmental moulds that can cause skin infection and sinusitis in both normal and immunosuppressed children. This study reviews paediatric cases of Exserohilum infection in Queensland, Australia, to identify the spectrum of disease and its clinical course.

Methods: All culture-positive samples of Exserohilum species in children <18 years of age were identified from the Queensland Health Laboratory database (April 2003-April 2018). Read More

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http://dx.doi.org/10.1111/myc.12864DOI Listing
February 2019
13 Reads

Urgent Infections of the Head and Neck.

Med Clin North Am 2018 Nov 20;102(6):1109-1120. Epub 2018 Sep 20.

Otolaryngology-Head and Neck Surgery, University of California, San Francisco, 2233 Post Street, 3rd floor, San Francisco, CA 94115, USA.

Infections of the head and neck are common and appropriately managed by primary care providers in most cases. However, some infections are associated with significant morbidity and require urgent recognition and management by specialty services. These include deep neck space infections originating in the oral cavity, pharynx, and salivary glands, as well as complicated otologic and sinonasal infection. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00257125183007
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http://dx.doi.org/10.1016/j.mcna.2018.06.015DOI Listing
November 2018
10 Reads

Surgical debridement for acute invasive fungal rhinosinusitis during the pre-engraftment phase of allogeneic hematopoietic stem cell transplantation: Two case reports.

Medicine (Baltimore) 2018 Oct;97(42):e12696

Department of Haematology, China Aerospace Central Hospital.

Rationale: Surgical intervention may be not a contraindication for acute invasive fungal rhinosinusitis (AIFR) during the pre-engraftment period of allogeneic hematopoietic stem cell transplantation (allo-HSCT).

Patient Concerns: We present 2 cases involving patients with AIFR in the pre-engraftment phase of allo-HSCT.

Diagnoses: Both patients received surgical debridement combined with systemic antifungal treatment. Read More

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http://Insights.ovid.com/crossref?an=00005792-201810190-0001
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http://dx.doi.org/10.1097/MD.0000000000012696DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211869PMC
October 2018
2 Reads

Retrobulbar optic neuropathy associated with sphenoid sinus mucormycosis.

Neurol Clin Neurosci 2018 Sep 10;6(5):146-147. Epub 2018 Jul 10.

Department of Neurology JA Toride Medical Center Toride Ibaraki Japan.

Because fungi usually spread from the paranasal sinuses to the orbital apex in invasive fungal sinusitis (IFS), IFS often presents as an orbital apex syndrome (OAS) characterized by dysfunction of cranial nerves II, III, IV, V1, and VI. We report a case of sphenoid sinus mucormycosis that presented as isolated retrobulbar optic neuropathy. A 94-year-old woman presented with acute blindness in the right eye. Read More

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http://dx.doi.org/10.1111/ncn3.12216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175081PMC
September 2018
2 Reads

Ophtalmoplegia complicating sino-orbital mucormycosis.

Tunis Med 2018 Mar;96(3):224-226

Purpose: To report a case of complete ophthalmoplegia and blindness in sino-orbital mucormycosis.

Case Report: A 68-year-old woman with history of diabetes and breast cancer presented with sudden onset of fever, orbital pain and blindness in the right eye. The patient was found to have no light perception, complete ophthalmoplegia, chemosis, corneal ulcer and optic nerve atrophy. Read More

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March 2018
2 Reads

Minimally invasive treatment of sino-nasal aspergillosis in dogs.

J Vet Intern Med 2018 Nov 16;32(6):2069-2073. Epub 2018 Oct 16.

Hospital for Small Animals, University of Edinburgh, Edinburgh, EH25 9RG, United Kingdom.

Background: Sino-nasal aspergillosis is a common nasal disease in dogs. Recommended treatment protocols typically involve trephination of the frontal sinuses or the use of an antifungal solution instilled into the frontal sinus under anesthesia, both of which have associated morbidity and complications.

Objectives: To assess a minimally-invasive topical treatment protocol for sino-nasal aspergillosis in dogs. Read More

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http://doi.wiley.com/10.1111/jvim.15311
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http://dx.doi.org/10.1111/jvim.15311DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271301PMC
November 2018
26 Reads

Measles during arbovirus outbreak: a diagnostic challenge.

JMM Case Rep 2018 Aug 10;5(8):e005156. Epub 2018 Aug 10.

Regional Measles Reference Laboratory, Victorian Infectious Diseases Reference Laboratory, Melbourne, Australia.

Introduction: Dengue fever is a major public health problem in New Caledonia, like in many Pacific Islands Countries and territories. In 2017 New Caledonia faced multiple circulations of arboviruses with a major outbreak of dengue and a co-circulating Zika virus. New Caledonia is considered as a non-endemic territory for measles since the mid 1990's. Read More

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http://www.microbiologyresearch.org/content/journal/jmmcr/10
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http://dx.doi.org/10.1099/jmmcr.0.005156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152402PMC
August 2018
8 Reads

Function of BriC peptide in the pneumococcal competence and virulence portfolio.

PLoS Pathog 2018 10 11;14(10):e1007328. Epub 2018 Oct 11.

Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA, United States of America.

Streptococcus pneumoniae (pneumococcus) is an opportunistic pathogen that causes otitis media, sinusitis, pneumonia, meningitis and sepsis. The progression to this pathogenic lifestyle is preceded by asymptomatic colonization of the nasopharynx. This colonization is associated with biofilm formation; the competence pathway influences the structure and stability of biofilms. Read More

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http://dx.doi.org/10.1371/journal.ppat.1007328DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181422PMC
October 2018
1 Read

Nested PCR for the detection of Aspergillus species in maxillary sinus samples of patients with chronic sinusitis.

Rev Iberoam Micol 2018 Jul - Sep;35(3):140-146. Epub 2018 Sep 28.

Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Jagiellonian University Medical College, Kraków, Poland.

Background: Fungal rhinosinusitis has become an increasingly recognized disease, being Aspergillus species responsible for most of the cases. Its diagnosis is quite difficult because of the non-specific symptoms and low sensitivity of the current diagnostic methods.

Aims: An Aspergillus-specific nested polymerase chain reaction (PCR) assay using biopsy specimens taken from the maxillary sinuses was performed in order to assess its usefulness. Read More

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http://dx.doi.org/10.1016/j.riam.2018.04.001DOI Listing
September 2018
23 Reads

Fatal case of cerebral aspergilloma complicated by ventriculitis and bacteremia due to Salmonella species in a sickle cell disease patient.

Saudi Med J 2018 Sep;39(9):935-939

Department of Pathology and Laboratory Medicine, College of Medicine, King Saud University and King Saud University Medical City, Riyadh, Kingdom of Saudi Arabia. E-mail.

To describe a fatal case of invasive Aspergillus flavus sinusitis in a 43-year old female with sickle cell disease (SCD) complicated by intracerebral aspergilloma and invasive Salmonella infection. Cerebral aspergilloma carries a very high mortality rate. The patient developed post-craniotomy intracerebral hemorrhage at the site of biopsy, Salmonella species sepsis and ventriculitis. Read More

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http://dx.doi.org/10.15537/smj.2018.9.22821DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201011PMC
September 2018
3 Reads

Headache Secondary to Isolated Sphenoid Sinus Fungus Ball: Retrospective Analysis of 6 Cases First Diagnosed in the Neurology Department.

Front Neurol 2018 7;9:745. Epub 2018 Sep 7.

Department of Neurology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, China.

Fungal sphenoid sinusitis is easily misdiagnosed in clinic, particularly for patients with normal immunological status. Due to the anatomic characteristics of sphenoid sinus, patients presented with various nonspecific symptoms and complications. Headache is the most common presentation, but location of headache is not fixed. Read More

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http://dx.doi.org/10.3389/fneur.2018.00745DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137194PMC
September 2018
2 Reads

Subperiosteal haematoma of the orbit secondary to frontal sinusitis.

BMJ Case Rep 2018 Sep 18;2018. Epub 2018 Sep 18.

ENT, Wexham Park Hospital, Slough, UK.

Reported is the case of a 79-year-old woman initially diagnosed with periorbital abscess on the background of a recent upper respiratory tract infection. Unexpectedly, intraoperative findings were that of a haematoma rather than an abscess. Subperiosteal orbital haematoma (SOH) is an extremely rare complication of rhinosinusitis. Read More

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http://dx.doi.org/10.1136/bcr-2018-226476DOI Listing
September 2018
4 Reads

Sinus Augmentation Failure and Postoperative Infections Associated with Prophylactic Clindamycin Therapy: An Observational Case Series.

Int J Oral Maxillofac Implants 2018 Sep/Oct;33(5):1136-1139

Purpose: This observational study was based on a series of clinical cases in which failure of sinus augmentations occurred in patients who received prophylactic clindamycin therapy.

Materials And Methods: Between the years 2006 and 2010, a retrospective observational study was performed. The study consisted of 1,874 patients (723 males and 1,151 females) in whom sinus augmentations were performed prior to placement of dental implants. Read More

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http://dx.doi.org/10.11607/jomi.6517DOI Listing
November 2018
1.491 Impact Factor

Clinical and laboratory features of seventy-eight UK patients with Good's syndrome (thymoma and hypogammaglobulinaemia).

Clin Exp Immunol 2019 Jan 21;195(1):132-138. Epub 2018 Oct 21.

Immunology, University of Manchester, Manchester University Hospitals NHS Trust, Manchester, UK.

Good's syndrome (thymoma and hypogammaglobulinaemia) is a rare secondary immunodeficiency disease, previously reported in the published literature as mainly individual cases or small case series. We use the national UK-Primary Immune Deficiency (UKPID) registry to identify a large cohort of patients in the UK with this PID to review its clinical course, natural history and prognosis. Clinical information, laboratory data, treatment and outcome were collated and analysed. Read More

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http://dx.doi.org/10.1111/cei.13216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300645PMC
January 2019
13 Reads