Search Our Scientific Publications & Authors

J Laryngol Otol 2021 Jun 22:1-4. Epub 2021 Jun 22.

ENT Surgery, Cambridge University Hospitals NHS Foundation Trust, Cambridge, England.

Objective: This study aimed to assess the quality and readability of websites on chronic rhinosinusitis.

Methods: A total of 180 results from 3 different search engines regarding 'chronic rhinosinusitis', 'sinusitis' and 'sinus infections' were analysed for readability using the Flesch-Kincaid Grade Level, Flesch Reading Ease Score and Gunning Fog Index. The Discern tool was used to approximate information quality. Read More

Intern Med 2021 Jun 19. Epub 2021 Jun 19.

Department of Respiratory Medicine, Saitama Cardiovascular and Respiratory Center, Japan.

A 58-year-old woman with rheumatoid arthritis (RA) visited our hospital complaining of a persistent cough and sputum for the past year. She had a high cold hemagglutinin titer and chronic sinusitis. Chest computed tomography revealed bilateral diffuse centrilobular nodules, bronchiectasis, and bronchial wall thickening. Read More

Laryngoscope 2021 Jun 19. Epub 2021 Jun 19.

Department of Otolaryngology, West Virginia University, Morgantown, West Virginia, U.S.A.

Objective: To evaluate the outcome of immunoglobulin (IG) replacement therapy in adults with rhinosinusitis and primary humoral immunodeficiency disorders (PID).

Study Design: Retrospective cohort study.

Methods: Retrospective chart review of adult (18 years and older) patients who were diagnosed with PID and had the diagnosis of recurrent acute rhinosinusitis (RARS) and chronic rhinosinusitis (CRS) and who are on IG replacement therapy. Read More

Arerugi 2021 ;70(4):315-320

Department of Respiratory Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University.

At the time of writing of this manuscript, four biologics were clinically available for treatment against severe asthma. The choice of four biologics has been taking into account of the results of several type 2 inflammationrelated biomarkers, and the comorbidities of asthma, such as eosinophilic chronic rhinosinusitis, allergic rhinitis, and atopic dermatitis.In this study, we have experienced a case of severe asthma complicated by eosinophilic chronic rhinosinusitis and eosinophilic otitis media, resulting in the use of four biologics, and we observed differential response of upper and lower airways. Read More

Arerugi 2021 ;70(4):310-314

Department of Pediatrics, Saitama Medical University Hospital.

A 12-year-old boy visited our hospital with complaints of chronic cough and dyspnea. Chest X-ray and CT revealed diffuse granular shadow in the bilateral lung fields and "Tree-in-bud appearance" in the peripheral airways, respectively. Sinusitis was present, and restrictive disorder was predominantly found in pulmonary function. Read More

Iran J Allergy Asthma Immunol 2021 Jun 6;20(3):263-270. Epub 2021 Jun 6.

Department of Immunology and Allergy, The Persian Gulf Tropical Medicine Research Center, The Persian Gulf Biomedical Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran.

Allergic rhinitis (AR) is a prevalent disease affecting the quality of life of patients throughout the world. This study aimed to assess the prevalence of AR and its association with chronic rhinosinusitis (CRS) in the adult population living in Bushehr, southwestern part of Iran. In this population-based study, a total of 5420  individuals aged 15-65 years were selected through a multi-stage, cluster, random sampling method from which 5201 of them completed the Global Allergy and Asthma Network of Excellence (GA2LEN) questionnaire (Response rate=96. Read More

Acta Virol 2021 ;65(2):127-140

Chronic rhinosinusitis (CRS) is an otolaryngological disease with a recalcitrant nature, predominantly due to antibiotic resistant bacteria and the biofilm formation. The intracellular residency of Staphylococcus aureus bacteria was observed in CRS. The overall prevalence of CRS is estimated between 5-15% in the human population, and biofilms were formed in sinuses in 40-80% of cases. Read More

Auris Nasus Larynx 2021 Jun 11. Epub 2021 Jun 11.

Department of Otorhinolaryngology, Faculty of Medicine Kocaeli University, Kocaeli, Turkey.

Objective: Osteomas are slow-growing benign osseous tumors that particularly located in the paranasal sinuses (PS). Here, we aimed to define the clinical symptoms and features, diagnostic conditions caused by osteomas located in four different PSs, to evaluate the surgical indications and methods, to compare the factors that can affect the surgical decision, radiological findings, and prognosis.

Methods: The data of patients with paranasal sinus lesions and diagnosed as osteoma according to the radiological imaging, who applied to our clinic between 2010 and 2020, were retrospectively collected and re-evaluated in the light of clinical, radiological, and pathological data. Read More

Cureus 2021 May 9;13(5):e14913. Epub 2021 May 9.

Paediatrics, Base Hospital, Mahaoya, LKA.

Childhood pneumococcal infection is a growing concern among paediatricians especially, in countries where there is no routine vaccination program against . The disease is associated with significant morbidity and mortality in young children particularly those who are under the age of two years. Its main virulent factors include polysaccharide capsule, autolysin, pneumolysin, choline-binding Protein A, the higher chance for genetic transformation, and the presence of pilli that facilitate enhanced binding of bacteria to host cellular surfaces. Read More

Otolaryngol Clin North Am 2021 Jun 8. Epub 2021 Jun 8.

Department of Otolaryngology-Head and Neck Surgery, 800 Harrison Avenue BCD5, Boston, MA 02118, USA.

There are many phenotypes of chronic sinusitis and clinical variables that differ between patients. The ability to accurately diagnose, predict prognosis, and select the appropriate treatment depends on the understanding of disease endotypes. Chronic sinusitis is in the early stages of disease endotyping. Read More

Fam Pract 2021 Jun 11. Epub 2021 Jun 11.

Yasuda Clinic, Internal Medicine, 2-2-20-2F, Takasago, Urawa-ku, Saitama-shi, Saitama, 330-0063, Japan.

Background: Upper airway cough syndrome (UACS) is generally considered a common cause of chronic cough but remains poorly recognised in Japan.

Objective: This study aimed to assess whether UACS was a common cause of chronic cough in Japan, as is true in other countries. Interview and examination items were evaluated for their potential use in UACS diagnosis. Read More

Braz J Otorhinolaryngol 2021 May 25. Epub 2021 May 25.

Chonnam National University Medical School & Hwasun Hospital, Department of Otolaryngology-Head and Neck Surgery, Hwasun, South Korea.

Introduction: Actinomycosis of the nasal cavity is very rare.

Objective: The purpose of this study was to investigate the clinical features, treatment methods, and treatment results of actinomycosis of the nasal cavity in our hospital.

Methods: We retrospectively enrolled 11 patients with histopathologically identified actinomycosis of the nasal cavity from January 2010 to May 2020. Read More

J Pak Med Assoc 2021 Jun;71(6):1605-1607

Department of Surgery, Aga Khan University Hospital, Karachi, Pakistan.

Objective: To determine the frequency of allergic fungal sinusitis among patients with nasal polyps, and to compare Lund-Mackay scores of patients with and without allergic fungal sinusitis.

Methods: The cross-sectional longitudinal study was conducted at a tertiary healthcare centre in Karachi, Pakistan, from December 2016 to November 2018, and comprised patients with sinonasal polyposis undergoing surgery. The patients were categorised as having allergic fungal sinusitis when histopathology showed allergic mucin with fungal hyphae and culture was positive for fungal growth. Read More

Turk Arch Pediatr 2021 1;56(3):236-244. Epub 2021 May 1.

Department of Child Health and Diseases, Department of Child Neurology, Ege University School of Medicine, İzmir, Turkey.

Objective: The study aimed to evaluate the patients with a diagnosis of cerebral sinovenous thrombosis in terms of clinical findings, etiology and underlying risk factors, imaging findings, treatment, and prognosis in the long term.

Materials And Methods: Medical records of 19 patients whose ages ranged between 0 days and 17 years with clinical and radiological cerebral sinovenous thrombosis in Ege University Department of Child Neurology were retrospectively evaluated.

Results: Nine of nineteen cases were female (47. Read More

BMC Surg 2021 Jun 8;21(1):288. Epub 2021 Jun 8.

Division of Epidemiology and Biostatistics, Department of Family and Community Medicine, College of Medicine, Imam Abdulrahman Bin Faisal University, Al Khobar, Saudi Arabia.

Background: Chronic rhinosinusitis (CRS) is a common inflammation of the nose and the paranasal sinuses. Intractable CRS cases are generally treated with endoscopic sinus surgery (ESS). Although the effect of ESS on CRS symptoms has been studied, the pattern of symptom improvement after ESS for CRS is yet to be investigated. Read More

Zhonghua Er Ke Za Zhi 2021 Jun;59(6):495-500

Department of Rheumatology and Immunology, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Developmental and Disorders, Chongqing Key Laboratory of Child Infection and Immunity, Chongqing 400014, China.

To analyze the clinical characteristics of congenital agammaglobulinemia and the efficacy of intravenous immunoglobulin (IVIG) replacement therapy for this disease. The basic characteristics, clinical manifestations, laboratory examinations, and outcomes of 114 patients with congenital agammaglobulinemia diagnosed in Children's Hospital of Chongqing Medical University from January 1988 to April 2020 were retrospectively analyzed. The efficacy of IVIG in improving the clinical symptoms between regular and irregular treatment groups were compared by χ test. Read More

J Coll Physicians Surg Pak 2021 Jun;30(6):699-702

Department of Otolaryngology, Suzhou Hospital of Integrated Traditional Chinese and Western Medicine, China.

Objective: To compare the therapeutic effects and olfactory function of oral glucocorticoid and intranasal glucocorticoid in patients with chronic rhinosinusitis (CRS) with nasal polyps.

Study Design: Experimental study.

Place And Duration Of Study: Suzhou Hospital of Integrated Traditional Chinese and Western Medicine, from January 2018 to November 2019. Read More

Acta Endocrinol (Buchar) 2020 Oct-Dec;16(4):511-517

"C.I.Parhon" National Institute of Endocrinology - Neuroendocrinology, Bucharest, Romania.

Introduction: Glucocorticoids (GC) are largely used for their anti-inflammatory and immunosuppressive effects. Until recently "local" administration (inhalation, topical, intra-articular, ocular and nasal) was considered devoid of important systemic side effects, but there is no administration form, dosing or treatment duration for which the risk of iatrogenic Cushing's syndrome (CS) and consequent adrenal insufficiency (AI) can be excluded with certainty.

Patients And Methods: We present the case of a pregnant woman who developed overt CS with secondary AI in the second trimester of pregnancy. Read More

Int Forum Allergy Rhinol 2021 Jun 2. Epub 2021 Jun 2.

Department of Otorhinolaryngology-Head and Neck Surgery, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, USA.

In the last two decades, the development of culture-independent genomic techniques has facilitated an increased appreciation of the microbiota-immunity interactions and their role in a multitude of chronic inflammatory diseases such as chronic rhinosinusitis (CRS), asthma, inflammatory bowel disease and dermatitis. While the pathologic role of bacteria in chronic inflammatory diseases is generally accepted, the understanding of the role of fungi remains controversial. Chronic rhinosinusitis, specifically the phenotype linked to nasal polyps, represents a spectrum of chronic inflammatory diseases typically characterized by a type 2 immune response. Read More

Int Forum Allergy Rhinol 2021 Jun 2. Epub 2021 Jun 2.

Department of Otolaryngology-Head and Neck Surgery, Emory University School of Medicine, Atlanta, Georgia, USA.

Background: Central compartment atopic disease (CCAD) is a variant of chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP) characterized by polypoid changes of the superior nasal septum, middle (MT), and/or superior turbinates (ST). This study evaluates surgical outcomes in patients with CCAD compared with other CRSwNP subtypes.

Methods: Retrospective analysis was performed at Emory University from May 2012 to November 2019. Read More

Laryngoscope 2021 Jun 1. Epub 2021 Jun 1.

Department of Otorhinolaryngology, Omori Medical Center, Toho University, Tokyo, Japan.

Objectives/hypothesis: This study investigated the relationships between anatomical findings around the eustachian tube (ET) and eosinophilic otitis media (EOM) accompanied by eosinophilic chronic rhinosinusitis (ECRS).

Study Design: This study employed axial, coronal, sagittal and oblique computed tomography.

Methods: Patients who underwent endoscopic sinus surgery at the Department of Otolaryngology, Toho University Medical Center Omori Hospital and were diagnosed with ECRS (106 patients) based on the Japanese Epidemiological Survey of Refractory Eosinophilic Chronic Rhinosinusitis study were included. Read More

Oral Dis 2021 May 31. Epub 2021 May 31.

Department of Public Health, School of Medical Sciences, University of Campinas-UNICAMP, Campinas, Brazil.

Objectives: Determine the prevalence of possible bruxism in the adult population of Campinas, Brazil, and investigate its association with health behaviors, health status, and multimorbidity.

Methods: A population-based cross-sectional study was conducted with data from the 2014/2015 Campinas Health Survey. The sample was composed of 1986 adults (≥20 years of age). Read More

BMC Surg 2021 May 28;21(1):269. Epub 2021 May 28.

Department of Otolaryngology, Head & Neck Surgery, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610091, China.

Background: Osteopetrosis is a rare inherited bone disorder affected individual by osteoclast disfunction and increasing bone density. Surgery was taken for histological examination of the specimen and evidence of malignancy was not found. Finally, X-ray and gene detection lead to the diagnosis. Read More

BMJ Case Rep 2021 May 26;14(5). Epub 2021 May 26.

ENT & Head and neck surgery, All India Institute of Medical Sciences, New Delhi, India.

Sinogenic intracranial and orbital complications are infrequent complications of chronic rhinosinusitis with nasal polyposis (CRSwNP), leading to potentially fatal intracranial and orbital sequelae. The mortality and morbidity associated with these complications remain high despite the widespread use of antibiotics. We report a patient with CRSwNP presenting with acute onset extradural empyema and sixth nerve palsy in whom the diagnosis was delayed, necessitating early surgical intervention. Read More

Ann Allergy Asthma Immunol 2021 May 23. Epub 2021 May 23.

US Value Evidence and Outcomes, US Medical Affairs, GSK, Research Triangle Park, NC, USA. Electronic address:

Background: Patients with severe asthma frequently have associated comorbidities, which can compound existing symptoms, complicating asthma management.

Objective: To describe mepolizumab's real-world effectiveness in patients with severe asthma stratified by common overlapping comorbidities.

Methods: This was a retrospective analysis of patients with asthma from the MarketScan Commercial and Medicare Supplemental Database initiating mepolizumab treatment (index date). Read More

J Cyst Fibros 2021 May 22. Epub 2021 May 22.

Department of Pediatric Pneumology, Immunology and Intensive Care Medicine, Charité - Universitätsmedizin, Berlin, Germany.

Background: Epidemiology and potential risk factors for cystic fibrosis arthropathy (CFA) were studied in a relevant cystic fibrosis (CF) patient cohort.

Methods: Cohort study of patients included in the German CF registry in 2016-2017. Descriptive analysis, exploratory tests and multivariable logistic regression were used to assess prevalence of CFA and associated potential risk factors for adult patients with/without chronic Pseudomonas aeruginosa infection. Read More

Am J Case Rep 2021 May 25;22:e929892. Epub 2021 May 25.

Department of Pediatric Gastroenterology, Hepatology and Nutrition, University of Nebraska Medical Center, Omaha, NE, USA.

BACKGROUND Anti-TNF-alpha therapies were the first class of biologics to be used in treatment of moderate to severe IBD. Immunosuppression status that develops from using anti-TNF-a therapies increases the risk of serious and opportunistic infections. We present here a rare case of serious infection that developed in an IBD patient while on anti-TNF therapy. Read More

ACR Open Rheumatol 2021 Jun 25;3(6):404-412. Epub 2021 May 25.

Vasculitis Clinic, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.

Objective: To describe clinical manifestations and outcomes in patients with eosinophilic granulomatosis with polyangiitis (EGPA) in North America.

Methods: Analysis of patients aged 18 years or older who fulfilled the 1990 American College of Rheumatology Classification Criteria for EGPA enrolled in the Vasculitis Clinical Research Consortium from 2003 to 2019. Main clinical characteristics, treatments, outcomes, and accumulated damage were studied. Read More

Acta Otorhinolaryngol Ital 2021 Apr;41(2):159-167

Department of Otorhinolaryngology, Faculty of Medicine and Dentistry, Medical University of Warsaw, Warsaw, Poland.

Introduction: Chronic rhinosinusitis (CRS) can be classified as eosinophilic (eCRS) or non-eosinophilic (neCRS) based on infiltration type. The SWI/SNF complex may be involved in the pathophysiology of CRS.

Aim: To assess the expression of the SWI/SNF complex in both CRS groups; to correlate blood eosinophil count (BEC), and histopathology eosinophil count (HPEC) with the SWI/SNF expression level in eCRS and neCRS. Read More

Ann Med Surg (Lond) 2021 Jun 8;66:102379. Epub 2021 May 8.

Oral and Maxillofacial, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Sinai University, Egypt.

Introduction: Chronic sinusitis can be considered a relative contraindication for sinus lifting procedure. However, its specific effects on bone height, infection and healing have not been as well investigated as its incidence as a post-operative complication.

Methods: A retrospective comparative investigation was executed to evaluate the impact of chronic sinusitis on sinus lifting procedures regarding bone height, infection, and healing scores. Read More