25,321 results match your criteria Sinusitis Chronic
J Craniofac Surg 2018 Dec 13. Epub 2018 Dec 13.
Department of Otolaryngology-Head and Neck Surgery, Gil Medical Center, Gachon University School of Medicine, Incheon, Republic of Korea.
The case of a 59-year-old woman who underwent endoscopic sinus surgery for right maxillary sinusitis 5 years before visiting our otorhinolaryngologic department complaining of right-sided facial depression was described in this study. Computed tomography (CT) scans revealed right facial depression and retraction of the orbital floor due to a hypoplastic right maxillary sinus. Symptoms and CT findings corresponded with silent sinus syndrome. Read More
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Dec;32(23):1826-1828
Department of Convalescence, People's Liberation Army Wuhan Sanatorium.
To study the effect of smoking on chronic rhinosinusitis with lower respiratory tract diseases and underlaying mechanism. The data of 54 patients diagnosed as CRS with lower respiratory disease (Group A) and 60 patients with CRS (Group B) from otolaryngology head and neck surgery in Wuhan Central Hospital and Renmin Hospital of Wuhan University from January 2014 to December 2017 were analyzed, retrospectively. According to the history of smoking, all patients were divided into smoking group (Group C) and non-smoking group (Group D). Read More
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Dec;32(23):1788-1791
Department of Otorhinolaryngology, the First Hospital of China Medical University, Shenyang, 110001, China.
To explore the application of lung function and exhaled nitric oxide in the evaluation of patients with chronic rhinosinusitis(CRS) with or without polyps who denied bronchial asthma history and planned to undergo endoscopic sinus surgery. Two hundred and thirty-two patients with CRS during April 2016 to April 2018 in our hospital were recruited in this study. All patients accepted lung function and exhaled nitric oxide test before surgery to evaluate whether accompanied with asthma, improvements after standardized drug therapy in patients with asthma. Read More
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Dec;32(23):1774-1778
Department of Otolaryngology Head and Neck Surgery, Nanjing General Hospital of PLA.
To investigate the clinical features of patients with chronic sinusitis with bilateral nasal polyps. The data of 134 patients with chronic sinusitis with bilateral nasal polyps were analyzed, retrospectively. Based on the results of the histopathological examination, patients were divided into eosinophilic chronic sinusitis with bilateral nasal polyps(ECRSwBNP) group and noneosinophilic chronic sinusitis with bilateral nasal polyps(nonECRSwBNP) group. Read More
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Oct;32(19):1515-1518
Chronic rhinosinusitis (CRS) is an inflammatory disease of the nasal airways and paranasal sinuses. The condition is defined by more than 12 weeks of nasal obstruction, nasal discharge, facial pain/pressure, and reduced/lost smell. CRS is commonly further classified into 2 subsets based on its clinical phenotype: those with polyps (CRSwNP) and those without (CRSsNP). Read More
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Oct;32(19):1495-1498
Department of Otorhinolaryngology Head Neck Surgery, Bejing You'an Hospital, Capital Medical University, Beijing,100069, China.
To explore the feasibility of endoscopic sinus surgery on HIVinfected patients. Twelve positive patients suffering from sinusitis undergoing endoscopic treatment were retrospectively analyzed. And the clinical characteristics,treatment and therapeutic effects were summarized. Read More
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Oct;32(19):1459-1463
Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, and Key Laboratory of Otolaryngology Head and Neck Surgery(Capital Medical University), Ministry of Education, Beijing, 100730, China.
To analyze the dynamic changes of the clinical features of chronic rhinosinusitis in recent 10 years, so as to deeply understand the characteristics of chronic rhinosinusitis, and to provide new ideas for treatment of chronic rhinosinusitis. This retrospective study was performed in patients who were diagnosed as chronic rhinosinusitis and enrolled. General information, clinical examination and pathological results were all collected, then patients' age, gender, the incidence of asthma and allergic rhinitis, peripheral eosinophil percentage, olfactory dysfunction and pathological results were statistically analyzed. Read More
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Sep;32(18):1377-1382
Department of Otolaryngology, the Second Affiliated Hospital of Wenzhou Medical University,Wenzhou, 325000, China.
To explore the prevalence of allergy in patients with acute rhinosinusitis (ARS) and evaluate the severity of symptoms in ARS children with or without allergy.Two hundred and seven children (4-12 years of age) with ARS and 85 children of control group were included in our research from June, 2016 to January, 2018. We use questionaire to collect the basic information of pediatric patients. Read More
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Dec;32(24):1870-1875
Department of Otolaryngology, Affiliated Eye Ear Nose and Throat Hospital, Fudan University, Shanghai, 200031, China.
The aim of this study is to investigate the involvement of Th17/Treg imbalance in the pathogenesis of bacterial biofilm (BBF) induced chronic rhinosinusitis(CRS). CRS nasal sinus mucosa was collected, and BBF was examined by BacLight/CSLM detection. Forty CRS cases(20 BBF positive cases and 20 negative cases) and 10 controls were enrolled. Read More
Laryngoscope 2018 Dec 14. Epub 2018 Dec 14.
Department of Otolaryngology-Head and Neck Surgery, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania.
Objectives/hypothesis: Chronic frontal sinus infection is managed with a combination of medical and surgical interventions. Frontal bone osteomyelitis due to recurrent infection following trauma or prior open surgery may require more significant debridement. Free tissue transfer may allow for extensive debridement with replacement of tissue, and definitive eradication of osteomyelitis. Read More
Int Forum Allergy Rhinol 2018 Dec 10. Epub 2018 Dec 10.
Department of Otorhinolaryngology-Head and Neck Surgery, Hallym University College of Medicine, Anyang, Korea.
Background: The purpose of this study was to evaluate the relations between gastroesophageal reflux disease (GERD) and chronic rhinosinusitus (CRS) in a Korean population.
Methods: Subjects from the Korean National Health Insurance Service-National Sample Cohort, all ≥20 years old, were assessed from 2002 to 2013. In total, 23,489 CRS participants were matched with 93,956 controls at a ratio of 1:4 with respect to age, group, sex, income group, region of residence, hypertension, diabetes, and dyslipidemia. Read More
Int Forum Allergy Rhinol 2018 Dec 10. Epub 2018 Dec 10.
Division of Rhinology and Sinus/Skull Base Surgery, Department of Otolaryngology-Head and Neck Surgery, Oregon Health and Science University, Portland, OR.
Background: Healthcare disparities related to socioeconomic factors may adversely impact disease states and treatment outcomes. Among patients with chronic rhinosinusitis (CRS), the impact of socioeconomic factors on outcomes following endoscopic sinus surgery (ESS) remains uncertain.
Methods: Adult patients with refractory CRS were prospectively enrolled into an observational, multi-institutional cohort study between March 2011 and June 2015. Read More
Res Social Adm Pharm 2018 Dec 7. Epub 2018 Dec 7.
School of Pharmacy, University of Waterloo, 10 Victoria St S A, Kitchener, N2G 1C5, ON, Canada; Ontario Pharmacy Evidence Network (OPEN), School of Pharmacy, University of Waterloo, 10 Victoria St S A, Kitchener, N2G 1C5, ON, Canada.
Background: Pharmacists have been shown to be beneficial for inclusion in emergency department (ED) services; however, little has been done to assess these benefits with pharmacists having even wider scopes of practice, including limited prescribing authority.
Objectives: The aims of this study were to determine the proportion of ED visits that can potentially be managed by pharmacists, the most prevalent conditions within these cases, and the factors associated with patients presenting with such cases to the ED.
Methods: This was a retrospective quantitative cohort study using administrative databases from 2010 to 2017. Read More
J Pediatr 2018 Dec 10. Epub 2018 Dec 10.
Division of General Academic Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA.
Objective: To develop a parent-reported Pediatric Rhinosinusitis Symptom Scale (PRSS) that could be used to monitor symptoms of young children with acute sinusitis in response to therapy.
Study Design: We developed an 8-item symptom severity scale and evaluated its internal reliability, construct validity, and responsiveness in children 2-12 years of age with acute sinusitis. Parents of 258 children with acute sinusitis completed the PRSS at the time of diagnosis, as a diary at home, and at the follow-up visit at days 10-12. Read More
Am J Rhinol Allergy 2018 Dec 13:1945892418816841. Epub 2018 Dec 13.
1 Department of Otolaryngology - Head and Neck Surgery, Virginia Commonwealth University School of Medicine, Richmond, Virginia.
Background: The impact of middle turbinate resection (MTR) on olfaction remains a point of debate in the current literature. Few studies have objectively evaluated olfactory cleft airflow following MTR; thus, the mechanism by which MTR may impact olfaction is poorly understood. It is not known whether the postsurgical changes in airway volume, flow, and resistance increase odorant transport or disrupt the patterns of normal airflow. Read More
Am J Otolaryngol 2019 Jan - Feb;40(1):115-120. Epub 2018 Jul 7.
Department of Otolaryngology, New York Eye and Ear Infirmary of Mount Sinai, New York, NY, United States.
Background: Headaches are commonly evaluated in otolaryngology and often represent a diagnostic dilemma. This review addresses rhinogenic headache as well as trigeminal neuralgia and migraine, both of which can masquerade as sinus headache and whose management increasingly involves otolaryngology intervention. Discussion considers diagnostic criteria and novel therapies and derives an algorithm for clinical decision-making. Read More
Chin Med J (Engl) 2018 Dec;131(24):2989-2990
Department of Neurology, The Affiliated Hospital of Jiujiang University, Jiujiang, Jiangxi 332000, China.
Oral Radiol 2018 Dec 11. Epub 2018 Dec 11.
Department of Oral and Maxillofacial Radiology, Aichi-Gakuin University School of Dentistry, 2-11 Suemori-dori, Chikusa-ku, Nagoya, 464-8651, Japan.
Objectives: To apply a deep-learning system for diagnosis of maxillary sinusitis on panoramic radiography, and to clarify its diagnostic performance.
Methods: Training data for 400 healthy and 400 inflamed maxillary sinuses were enhanced to 6000 samples in each category by data augmentation. Image patches were input into a deep-learning system, the learning process was repeated for 200 epochs, and a learning model was created. Read More
Auris Nasus Larynx 2018 Dec 8. Epub 2018 Dec 8.
Department of Otorhinolaryngology, Toho University Graduate School of Medicine, Japan; Department of Otorhinolaryngology, Toho University Omori Medical Center, Japan. Electronic address:
Objective: Continuous positive airway pressure (CPAP) is the mainstay therapy for patients with obstructive sleep apnea (OSA) however compliance with CPAP is variable. Nasal ailments, such as nasal congestion are frequently mentioned as a cause for CPAP non-compliance, and potentially could be addressed prior to CPAP initiation, however, no specific criteria or recommendations for the evaluation and management of these patients exist. The aim of this retrospective study is to evaluate the effects of nasal anatomic features and disease on adherence to CPAP therapy for patients with OSA and determine the indications for pre-CPAP nasal treatment by using data obtained at clinical examination. Read More
Respir Med Case Rep 2019 24;26:59-62. Epub 2018 Nov 24.
Department of Respiratory Medicine, Saitama Cardiovascular and Respiratory Center, Japan.
A 56-year-old woman was referred to our hospital for recurrent asthma of 20 years duration. She was diagnosed as having allergic bronchopulmonary aspergillosis on the basis of clinical symptoms, peripheral blood eosinophilia, elevated total serum immunoglobulin E value, positive results of specific IgE and precipitating antibodies against sp., central bronchiectasis, and mucoid impaction. Read More
Int J Surg Case Rep 2018 Nov 16;54:60-62. Epub 2018 Nov 16.
Consultant ENT, Rhinology and Endoscopic Skull Base Surgery at King Fahad Specialist Hospital, Dammam, Saudi Arabia.
Objectives: to report the alternating nature of allergic fungal rhinosinusitis in children in the Eastern part of Saudi Arabia and to review the experience of King Fahad Specialist Hospital in the diagnosis and management of alternating allergic fungal rhinosinusitis in children. An 8 years old Saudi girl with alternating allergic fungal rhinosinusitis was diagnosed and managed. The patient was diagnosed to have unilateral left allergic fungal rhinosinusitis and underwent endoscopic sinus surgery and cleaning of the left sinuses from polyps, mud and mucin. Read More
Eur Ann Otorhinolaryngol Head Neck Dis 2018 Dec 4. Epub 2018 Dec 4.
Département d'otorhinolaryngologie/chirurgie cervico-faciale/chirurgie de la base du crâne, université Paris-Diderot, hôpital Lariboisière, AP-HP, Paris, France.
Introduction: Chronic invasive fungal rhinosinusitis (CIFR) is a rare entity generally observed in immunodepressed subjects. The pathogen most frequently identified is Aspergillus spp. Imaging generally reveals invasive pseudoneoplastic features. Read More
Infect Drug Resist 2018 8;11:2199-2205. Epub 2018 Nov 8.
Department of Health Sciences, Medical School, University of Catanzaro "Magna Græcia", Catanzaro, Italy,
Purpose: The overuse, misuse, and underuse of antimicrobial agents often lead to the spread of antibiotic-resistant microorganisms. The aim of our study was to describe the pattern of antibiotic prescriptions for acute respiratory tract infections (RTIs) among the adult population and the factors associated with antibiotic prescribing.
Patients And Methods: The study involved patients who visited a general practitioner with suspected acute RTI. Read More
Curr Opin Allergy Clin Immunol 2018 Nov 29. Epub 2018 Nov 29.
Department of Otolaryngology - Head & Neck Surgery, University of Arizona College of Medicine, Tucson, Arizona, USA.
Purpose Of Review: Surfactant protein-A (SP-A) is a collectin protein expressed in airway epithelia that is critical in the modulation of both innate and adaptive immunity against inhaled pathogens. In this review, we highlight associations of altered SP-A function in asthma and chronic rhinosinusitis, and its potential role as a targeted therapy for sinusitis.
Recent Findings: SP-A has been shown to bind and opsonize inhaled pathogens, thereby clearing bacteria through phagocytosis. Read More
Curr Opin Otolaryngol Head Neck Surg 2018 Dec 12. Epub 2018 Dec 12.
Rhinology & Endoscopic Skull Base Surgery, UCLA Department of Head & Neck Surgery, Los Angeles, California, USA.
Purpose Of Review: The purpose of the review is to evaluate the current indications and contraindications for balloon sinuplasty and review the clinical trials performed in this area.
Recent Findings: The indications for balloon sinus dilatation are somewhat similar to those for endoscopic sinus surgery. Balloon sinus ostial dilation (BSD) has been found to be most effective in the treatment of recurrent acute sinusitis (RARS) and chronic rhinosinusitis without nasal polyposis (CRSsNP) that has been refractory to medical therapy. Read More
Eur Arch Otorhinolaryngol 2018 Nov 30. Epub 2018 Nov 30.
Department of Otolaryngology-Head and Neck Surgery, Tri-Service General Hospital, National Defense Medical Center, No. 325, Cheng-Kung Road Section 2, Taipei 114, Taiwan, ROC.
Objective: Nasal septal abscess is an uncommon condition but it can cause potentially life-threatening intracranial complications and cosmetic nasal deformity.
Methods: We analyzed ten years of cases to determine the optimal diagnostic and therapeutic modalities. A retrospective review of case notes from Tri-Service General Hospital archives was performed. Read More
World J Otorhinolaryngol Head Neck Surg 2018 Sep 31;4(3):216-221. Epub 2018 Oct 31.
Department of Surgery, The University of Auckland, Grafton, Auckland, New Zealand.
Chronic rhinosinusitis (CRS) is a multifactorial condition in which the microbiota plays a pathogenic role. The nature of the interaction between the microbiota and the local immune system is very complex and has not been fully elucidated. Recent improvements in the microbiological techniques have greatly advanced our understanding of the complex nature of this interaction. Read More
World J Otorhinolaryngol Head Neck Surg 2018 Sep 31;4(3):193-199. Epub 2018 Oct 31.
Department of Otolaryngology Head & Neck Surgery, University of Alabama at Birmingham, Birmingham, AL, USA.
Sinonasal respiratory epithelium is a highly regulated barrier that employs mucociliary clearance (MCC) as the airways first line of defense. The biological properties of the airway surface liquid (ASL), combined with coordinated ciliary beating, are critical components of the mucociliary apparatus. The ASL volume and viscosity is modulated, in part, by the cystic fibrosis transmembrane conductance regulator (CFTR). Read More
World J Otorhinolaryngol Head Neck Surg 2018 Sep 9;4(3):179-185. Epub 2018 Nov 9.
McGovern Medical School at the University of Texas Health Science Center, Department of Otorhinolaryngology-Head & Neck Surgery, Houston, TX 77030, USA.
Studying the pathophysiology of allergic fungal rhinosinusitis (AFRS) has proved challenging. While this clinical entity is easily distinguishable based on the clinical criteria set forth by Bent and Kuhn twenty-five years ago, studies examining type 2 inflammatory profiles in AFRS can make it seem more alike other CRS subtypes than it is different. Still, evolving research seems to clearly delineate this subtype from others in CRS. Read More
World J Otorhinolaryngol Head Neck Surg 2018 Sep 24;4(3):169-174. Epub 2018 Aug 24.
Department of Otolaryngology, Santa Casa de Sao Paulo School of Medical Sciences, RuaDoutorCesário Motta Júnior, 61 - Vila Buarque, São Paulo, SP, 01221-020, Brazil.
Chronic rhinosinusitis (CRS) is a heterogeneous definition that includes different disease states that usually are associated with abnormal inflammatory responses. Besides being prevalent, the mechanisms involved in its pathogenesis are not clear and there are few therapeutic options with tolerable side effects. P-glycoprotein (P-gp) is an efflux pump responsible of extruding xenobiotics and cellular metabolites from multiple cell types. Read More
Public Health Nutr 2018 Dec 3:1-9. Epub 2018 Dec 3.
2Malawi-Liverpool-Wellcome Trust Clinical Research Programme,Blantyre,Malawi.
Objective: To assess differences in cognition functions and gross brain structure in children seven years after an episode of severe acute malnutrition (SAM), compared with other Malawian children.
Design: Prospective longitudinal cohort assessing school grade achieved and results of five computer-based (CANTAB) tests, covering three cognitive domains. A subset underwent brain MRI scans which were reviewed using a standardized checklist of gross abnormalities and compared with a reference population of Malawian children. Read More
J Stomatol Oral Maxillofac Surg 2018 Nov 26. Epub 2018 Nov 26.
Department of Maxillofacial Surgery, Nantes University Hospital, 1, place Alexis-Ricordeau, 44093 Nantes cedex 1, France.
Fractures of the frontal sinus are classified according to the topography (anterior wall, posterior wall or both), the displacement, and the presence of associated lesions (wound, nasofrontal duct injury, rhinorrhea). Isolated fractures of the anterior wall require surgical management, if the displacement is over 4 mm, to restore the forehead symmetry, to maintain the sinus ventilation and to avoid long-term complications (sinusitis, mucocele, meningitis…). Coronal incision is commonly performed but less invasive techniques are more and more used. Read More
Mymensingh Med J 2018 Oct;27(4):898-903
Dr Shameem Ahmed, Senior Consultant Neurosurgeon, Department of Neurosurgery, Apollo Hospitals (Unit: International Hospital), Guwahati , India.
Staphylococcus aureus is a global bacterial pathogen. It is an uncommon pathogen causing central nervous system infections, accounting for <1% cases of bacterial meningitis. Sinusitis, trauma and presence of an intracranial device have been reported as risk factors for developing meningitis and brain abscesses. Read More
Clin Rheumatol 2018 Nov 27. Epub 2018 Nov 27.
Department of Nephrology Center, Toranomon Hospital, 2-2-2, Toranomon, Minatoku, 105-8470, Japan.
Objectives: Hypertrophic pachymeningitis (HP) is a rare complication in patients with anti-neutrophil antibody-associated vasculitis (AAV); its clinical features, incidence, and risk factors remain unknown. We aimed to clarify the prevalence, clinical features, and factors associated with new-onset HP in patients with AAV.
Method: A retrospective cohort study involving 93 patients with AAV was conducted. Read More
Eur Arch Otorhinolaryngol 2018 Nov 27. Epub 2018 Nov 27.
Otolaryngology Unit, Department of Health Sciences, San Paolo Hospital, University of Milan, Via A. di Rudinì, 8, 20142, Milan, Italy.
Purpose: Odontogenic sinusitis and sinonasal complications of dental disease or treatment (SCDDT) represent a heterogeneous group of conditions that often require multidisciplinary care. The present study aims to prospectively validate a classification and treatment protocol for SCDDT patients.
Methods: One hundred twenty-eight consecutive patients (73 females and 45 males, mean age 52. Read More
J Infect Chemother 2018 Oct 25. Epub 2018 Oct 25.
Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Japan. Electronic address:
In paediatric patients, β-lactams and macrolides are widely used to treat acute otitis media and sinusitis, which are often caused by either Streptococcus pneumoniae or Haemophilus influenzae. However, resistant isolates have emerged and are becoming more prevalent. H. Read More
Am J Rhinol Allergy 2018 Nov 28:1945892418815044. Epub 2018 Nov 28.
4 Department of Otolaryngology-Head & Neck Surgery, Albaha University, Al Bahah, Saudi Arabia.
Background: Although several studies have commented on causes of dacryocystorhinostomy (DCR) failure, detailed description of anatomical findings in such cases remains insufficient.
Objective: Our objective was primarily to analyze radiologic, endoscopic, and intraoperative findings in patients presenting with failed DCR and secondarily to assess the outcome of revision endoscopic DCR (endo-DCR) carried out at our institution.
Methods: Twenty-four failed DCRs presenting to our tertiary care center were retrospectively analyzed. Read More
Am J Rhinol Allergy 2018 Nov 28:1945892418813079. Epub 2018 Nov 28.
1 Dalhousie Medicine New Brunswick, Saint John, New Brunswick, Canada.
Background: Complementary and alternative medicine (CAM) is frequently used in the treatment of chronic rhinosinusitis (CRS) in developed countries. With a plethora of CAM therapies available, their effectiveness and safety are poorly understood in the context of CRS.
Objectives: This article aims to critically appraise the evidence for CAM use in CRS through a systematic review of current literature that investigate the effects of CAM on symptoms and clinical status of adults with CRS. Read More
Otolaryngol Head Neck Surg 2018 Nov 27:194599818815109. Epub 2018 Nov 27.
3 Division of Otolaryngology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Objective: The microbiology of pediatric complicated acute rhinosinusitis (ARS) has evolved, and our current understanding of pathogenic organisms is limited. The objectives of this study are to describe the incidence of pathogens causing complicated ARS requiring surgical intervention at our institution over a 10-year period as well as their associated treatment outcomes.
Study Design: Retrospective cohort study. Read More
OTO Open 2018 Jan-Mar;2(1):2473974X18764879. Epub 2018 Mar 13.
Ochsner Clinic School, University of Queensland, New Orleans, Louisiana, USA.
Objectives: Frontal sinus anatomy is complex, and multiple variations of ethmoid pneumatization have been described that affect the frontal outflow tract. In addition, the lumen proper of the frontal sinus may exist as 2 separate parallel cavities that share an ipsilateral outflow tract. This variant has not been previously described and may have implications for surgical management. Read More
Respirol Case Rep 2019 Jan 21;7(1):e00388. Epub 2018 Nov 21.
Department of Respiratory Medicine National Hospital Organization Okayama Medical Center Okayama City Okayama Japan.
A 64-year-old woman, who had presented with a 30-year history of refractory asthma, and been treated with anti-allergic drug therapy, inhaled corticosteroids, a long-acting beta-agonist, and a long-acting muscarinic antagonist. She had been characterized as an allergic, eosinophilic asthmatic. Although omalizumab was tried initially, it was found to be insufficient. Read More
BMC Infect Dis 2018 Nov 26;18(1):595. Epub 2018 Nov 26.
AcademicLaboratory of Parasitology and Mycology, Andrée Rosemon Hospital, 97306, Cayenne, French Guiana.
Background: American histoplasmosis is a mycosis caused by Histoplasma capsulatum. A variety of clinical features of histoplasmosis have been commonly described ranging from asymptomatic infections to severe pulmonary infections. In immunocompromised individuals, progressive disseminated forms are frequent, leading to fatal outcome if untreated. Read More
J Craniofac Surg 2018 Nov 20. Epub 2018 Nov 20.
Department of Otorhinolaryngology, Dokkyo Medical University Saitama Medical Center.
Pott's puffy tumor (PPT) is a rare, life-threatening complication of frontal sinusitis that is treated with a combination of appropriate antibiotics and surgery for the removal of infected tissue. A 56-year-old man with recurrent forehead swelling was admitted and diagnosed with recurrent PPT. He had undergone endoscopic sinus surgery and pericranial abscess drainage. Read More
Inflamm Regen 2018 19;38:20. Epub 2018 Nov 19.
Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, Japan.
Background: In granulomatosis with polyangiitis (GPA), peripheral nerve involvement is common but central nervous system (CNS) involvement is extremely rare and treatment strategy has not been established. We report a case of intravenous cyclophosphamide (IVCY)-resistant GPA with associated cranial neuropathies that was successfully treated with rituximab (RTX).
Case Presentation: A 37-year-old man with intractable sinusitis had several months of headache, hoarseness, and dysphagia; a month of right-sided deafness and nasal bleeding; and a week of dysarthria, steppage gait, and numbness in the right L5 distribution. Read More
Am J Otolaryngol 2018 Oct 2. Epub 2018 Oct 2.
Headache Medicine, Yale Neuroscience Center, New Haven, CT, USA. Electronic address:
Background: Treatment of rhinosinusitis (RS) is one of the leading reasons for prescriptions of antibiotics, although they often fail to provide symptomatic relief. Appropriately diagnosing and treating patients presenting with RS for whom antibiotic therapy has failed or who have normal CT findings is a controversial topic. One explanation is that what these patients are experiencing is misinformation from the trigeminal nerve and autonomic nervous system. Read More
Int Forum Allergy Rhinol 2018 Nov 24. Epub 2018 Nov 24.
Department of Otolaryngology-Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, AL.
Background: Ivacaftor is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator that improves pulmonary function in cystic fibrosis (CF) patients with at least 1 copy of the G551D CFTR mutation. The purpose of this study is to evaluate the impact of ivacaftor on chronic rhinosinusitis (CRS) symptoms in this population.
Methods: The G551D Observational (GOAL) study was a multicenter prospective cohort study enrolling CF patients ≥6 years with at least 1 G551D mutation. Read More
Am J Otolaryngol 2019 Jan - Feb;40(1):101-105. Epub 2018 Sep 25.
Department of Otolaryngology-Head and Neck Surgery, Augusta University, 1120 15th Street, BP-4109, Augusta, GA 30912, United States of America.
Objective: Previous studies have not examined the potential role of endonasal hemostatic agents in facilitating growth of fungal species. We aim to determine the possibility of these to serve as a nutrient source for fungal growth.
Methods: Cultures of Aspergillus, Fusarium, and Mucor were harvested and placed in solution in sterile saline at standardized high and low concentrations. Read More
Rhinology 2018 Nov 24. Epub 2018 Nov 24.
Service d'Oto-rhino-laryngologie, Cliniques universitaires Saint-Luc, Brussels, Belgium.
Background: Treatment of chronic rhinosinusitis (CRS) aims to treat the underlying inflammation or infection. Although the optimal modality of administration remains controversial, inhalation route is usually preferred. The aim of this systematic review was to summarize the efficacy of intranasal corticoisteroids or antibiotics delivery by nebulization on symptoms, histology, endoscopy scores, nasal obstruction, clinical outcomes and quality of life in CRS. Read More
Anat Rec (Hoboken) 2018 Nov 24. Epub 2018 Nov 24.
Des Moines University, College of Osteopathic Medicine, Department of Anatomy, 3200 Grand Ave, Des Moines, Iowa, 50312.
Among humans, superiorly located maxillary sinus ostia (MSO) result in drainage complications and maxillary sinus (MS) disease. While previous studies investigate maxillary sinusitis frequency or MSO-position relative to specific nasal landmarks, few explore MSO-position to overall MS dimensions. This study investigates whether MSO-position relates to MS size/shape and if sex-based differences exist. Read More
Phytomedicine 2018 Dec 20;51:112-119. Epub 2018 Jun 20.
Department of Applied Biological Chemistry, Graduate School of Bioscience and Biotechnology, Chubu University, 1200 Matsumoto-cho, Kasugai, Aichi 487-8501, Japan. Electronic address:
Background: Epimagnolin A is an ingredient of the Chinese crude drug Shin-i, derived from the dried flower buds of Magnolia fargesii and Magnolia flos, which has been traditionally used for the treatment of allergic rhinitis and nasal congestion, empyema, and sinusitis. The pharmacokinetic activity of epimagnolin A remains to be evaluated.
Purpose: In this study, we examined the possible interactions of epimagnolin A with human ATP-binding cassette (ABC) transporter ABCB1, a membrane protein vital in regulating the pharmacokinetics of drugs and xenobiotics. Read More