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World J Otorhinolaryngol Head Neck Surg 2019 Mar 7;5(1):19-25. Epub 2018 Sep 7.

St. Paul's Sinus Centre, Division of Otolaryngology, Department of Surgery, St. Paul's Sinus Centre, Vancouver, BC, Canada.

Objective: To identify the differences in cytokine expression between sinonasal tissue from patients treated with Leptospermum (Manuka) honey (LH) irrigation versus normal saline irrigation twice-daily for twelve weeks following sinus surgery (FESS).

Methods: Forty-six CRS patients were recruited. Sinus tissue biopsies were collected during FESS and then at 5 and 12 weeks postoperatively during the course of treatment. Read More

J Asthma Allergy 2019 25;12:43-58. Epub 2019 Jan 25.

Respiratory, US Medical Affairs, GSK, La Jolla, CA, USA.

Purpose: Patients with severe asthma are eligible for asthma-specific biologics as add-on therapies, such as mepolizumab and omalizumab, when optimized controller therapies are unable to control their symptoms. However, few real-world data are available to describe the characteristics and associated economic burden of patients considered to be candidates for mepolizumab or omalizumab therapy.

Methods: This retrospective cohort study investigated patients with asthma (≥12 years of age) identified at the time of first mepolizumab or omalizumab administration (index date) in the MarketScan Commercial Database. Read More

J Laryngol Otol 2019 Feb 18:1-5. Epub 2019 Feb 18.

Department of Otolaryngology Head and Neck Surgery,Westmead Hospital,Sydney,Australia.

Objective: Chronic maxillary atelectasis is a rare and underdiagnosed condition in which there is a persistent and progressive decrease in maxillary sinus volume secondary to inward bowing of the antral walls. Chronic maxillary atelectasis is typically unilateral. Simultaneous bilateral chronic maxillary atelectasis is extremely uncommon. Read More

Heart 2019 Feb 14. Epub 2019 Feb 14.

University Hospital Hairmyres, East Kilbridge, UK.

CLINICAL INTRODUCTION: A 50-year-old woman presented with an inferoposterior ST-elevation myocardial infarction (STEMI) and underwent emergency percutaneous coronary intervention (PCI). Angiography revealed acute occlusion of the circumflex and right coronary (RCA) arteries. PCI was uncomplicated. Read More

Med Sci (Basel) 2019 Feb 5;7(2). Epub 2019 Feb 5.

Department of Otolaryngology, Head and Neck Surgery, Kansai Medical University, Hirakata 573-1010, Japan.

Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a refractory upper airway disease, accompanied mainly by eosinophilia and/or asthma. In addition, the disease correlates with a high rate of hyposmia, following a marked infiltration of eosinophils into the inflamed site, the paranasal sinus. Although eosinophils are known to contribute to the development of hyposmia and CRSwNP pathology, the underlying mechanisms remain unclear. Read More

Int Forum Allergy Rhinol 2019 Feb 12. Epub 2019 Feb 12.

Division of Rhinology and Sinus Surgery, Department of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, SC.

Background: Sinonasal symptoms and poor quality of life (QOL) prompt chronic rhinosinusitis (CRS) patients to undergo sinus surgery (ESS). However, little is known regarding the symptoms most important to patients and how these impact expectations and postoperative satisfaction.

Methods: A prospective, multi-institutional cohort study of 100 CRS patients undergoing ESS completed a novel adaptation of the 22-item Sino-Nasal Outcome Test (SNOT-22) wherein they rated how important it was for specific symptoms to improve after surgery, along with preoperative expectations and postoperative satisfaction. Read More

Laryngoscope 2019 Feb 11. Epub 2019 Feb 11.

Department of Otolaryngology, Bangkok, Thailand.

Objective: To assess the prognostic factors that predict favorable outcomes of low-dose macrolides (LDMs) in treating chronic rhinosinusitis (CRS).

Methods: Randomized controlled trials studying the effects of LDMs in treating CRS were included. Data were pooled for meta-analysis. Read More

Eur Arch Otorhinolaryngol 2019 Feb 9. Epub 2019 Feb 9.

Department of Medical Biochemistry, Medical Faculty Cerrahpaşa, University of Istanbul, Istanbul, Turkey.

Purpose: The aim of this study is to investigate serum and tissue procalcitonin (PCT) levels in patients with nasal polyps.

Methods: The study was designed to be prospectively controlled and included 26 patients chronic rhinosinusitis with nasal polyp (CRSwNP) endoscopically diagnosed and as a control group 25 chronic rhinosinusitis without nasal polyp (CRSsNP). NP specimens, nasal mucosal tissue and venous blood samples of both groups were collected and PCT levels determined by Elisa method. Read More

Eur Arch Otorhinolaryngol 2019 Feb 9. Epub 2019 Feb 9.

Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Innsbruck, Anichstr. 35, 6020, Innsbruck, Tyrol, Austria.

Purpose: The sino-nasal outcomes test-22 (SNOT-22) represents the reference questionnaire to assess patients with chronic rhinosinusitis (CRS). As weak correlations between objective CRS parameters and SNOT-22 total score have been observed, factor analyses have aimed to identify underlying factorial structures. However, ambiguous factor loadings and problematic item-domain assignments have resulted. Read More

ORL J Otorhinolaryngol Relat Spec 2019 Feb 8;81(1):41-47. Epub 2019 Feb 8.

Otolaryngology, Head and Neck Surgery, Assuta Medical Center, Ben Gurion University, Tel Aviv,

Background: Complete removal of some maxillary sinus pathologies may be challenging. We describe our experience in performing endoscopic inferior meatal antrostomy (EIMA) when approaching certain chronic maxillary sinus disease.

Methods: Retrospectively reviewing charts of all patients whose surgery included EIMA between the years 2012 and 2015. Read More

J Allergy Clin Immunol 2019 Feb 7. Epub 2019 Feb 7.

Department of Otolaryngology, Mayo Clinic, Phoenix, AZ; Division of Allergy, Asthma, and Clinical Immunology, Mayo Clinic, Scottsdale, AZ; Division of Pulmonology, Phoenix Children's Hospital, Phoenix, AZ. Electronic address:

Eosinophil peroxidase is a potential biomarker for eosinophilic chronic rhinosinusitis. Th2/Th1 polarization, as measured by GATA3 and T-bet, was not associated with eosinophilia or any clinical or histopathologic feature of chronic rhinosinusitis. Read More

J Mycol Med 2019 Feb 6. Epub 2019 Feb 6.

SSA, IRD, IHU - Méditerranée Infection, VITROME, Aix-Marseille Université, AP-HM, 13005 Marseille, France.

Fungus ball is the most common form of non-invasive fungal rhinosinusitis. Aspergillusfumigatus (between 44.8% and 75%) and Aspergillusflavus (14%) are the two most common species recovered. Read More

mSphere 2019 Feb 6;4(1). Epub 2019 Feb 6.

Department of Surgery, The University of Auckland, Auckland, New Zealand

Chronic rhinosinusitis (CRS) is a heterogeneous condition characterized by persistent sinus inflammation and microbial dysbiosis. This study aimed to identify clinically relevant subgroups of CRS patients based on distinct microbial signatures, with a comparison to the commonly used phenotypic subgrouping approach. The underlying drivers of these distinct microbial clusters were also investigated, together with associations with epithelial barrier integrity. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Nov;32(22):1700-1703

Department of Otolaryngology Head and Neck Surgery, Renmin Hospital, Wuhan University.

To study the CT features of patients with chronic rhinosinusitis(CRS) complicated with bronchial asthma(BA). Thirty-three cases of CRS with BA in patients with chronic sinusitis, 60 cases of CRS patients as control group, statistical Lund-Mackay sinus CT score and the incidence of nasal anatomical variation. The anatomical variation types in the two groups were mainly nasal septum deviation, middle turbinate gasification, uncinate process, Onodi air chamber, Lund and-Mackay sinus CT score. Read More

J Clin Med 2019 Jan 30;8(2). Epub 2019 Jan 30.

Department of Otolaryngology ⁻ Head and Neck Surgery, Chiayi Chang Gung Memorial Hospital, Chiayi 613, Taiwan.

Objective: To investigate the risk of chronic rhinosinusitis (CRS) among patients with Sjögren's syndrome (SS).

Method: A total of 18,723 patients diagnosed with SS between 1997 and 2011 were retrospectively analyzed. Moreover, 59,568 patients without SS were matched to patients with SS at a 1:4 ratio on the basis of sex, age, urbanization level, income level, and the comorbidities of rhinitis and nasal sepal deviation. Read More

Am Fam Physician 2019 Feb;99(3):188

Tufts University, Boston, MA, USA.

Int Forum Allergy Rhinol 2019 Jan 31. Epub 2019 Jan 31.

Department of Otolaryngology, Harvard Medical School, Boston, MA.

Background: The objective of this study was to evaluate the impact of bilateral inferior turbinate reduction (BITR) on patient-reported quality of life (QOL) following endoscopic sinus surgery (ESS) for chronic rhinosinusitis (CRS).

Methods: This was a prospective cohort study. Patients with CRS, who were recruited from 10 different otolaryngologic practices between 2011 and 2014, completed the 22-item Sino-Nasal Outcome Test (SNOT-22), Chronic Sinusitis Survey (CSS), and EuroQol 5 Dimension (EQ-5D) survey at baseline, and at 12, 24, 36, and 48 months after ESS. Read More

Int Forum Allergy Rhinol 2019 Jan 31. Epub 2019 Jan 31.

Department of Otolaryngology-Head & Neck Surgery, University of Alabama at Birmingham, Birmingham, AL.

Background: We recently developed a novel ciprofloxacin-coated sinus stent capable of releasing antibiotics over a sustained period of time. Ivacaftor is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator that has synergistic bactericidal activity with ciprofloxacin and also enhances sinus mucociliary clearance. The objective of this study was to optimize and evaluate the efficacy of a ciprofloxacin- and ivacaftor-releasing biodegradable sinus stent (CISS) in vitro. Read More

Zhonghua Kou Qiang Yi Xue Za Zhi 2019 Feb;54(2):87-93

Department of Periodontology, School of Stomatology, China Medical University & Liaoning Institute of Dental Research, Shenyang 110002, China.

To analysis the effect of nonoperative periodontal treatment on morphological changes of the schneiderian membrane of maxillary sinus in the chronic periodontitis patients by using oro-maxillaofacial cone-beam CT (CBCT) in order to provide the foundation in the diagnosis and treatment of maxillary sinusitis caused by chronic periodontitis. Totally 30 chronic periodontitis patients with schneiderian membrane thickening [(40.0±5. Read More

Ci Ji Yi Xue Za Zhi 2019 Jan-Mar;31(1):63-65

Department of Pediatrics, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.

Isolated sphenoid sinusitis is a rare disorder and may present with severe complications due to its proximity to the orbital and intracranial areas. We report a 13-year-old boy hospitalized for septic shock with fever of unknown origin. Facial palsy was later noted. Read More

Eur Arch Otorhinolaryngol 2019 Jan 28. Epub 2019 Jan 28.

Department of Surgery and Translational Medicine, Clinic of Otolaryngology, Head and Neck Surgery, Careggi University Hospital, University of Florence, Largo Brambilla, 3-50134, Florence, Italy.

Purpose: Cystic Fibrosis (CF) is the most common autosomal recessive disease in Caucasian population. Due to its pathological mechanism, chronic rhino sinusitis (CRS) associated or not with nasal polyposis usually occurs in adults and affects close to one-half of all CF patients. The goal of our work was to evaluate the impact of Endoscopic Sinus Surgery (ESS) in the quality of life (QoL) of the CF patients and demonstrate an improvement of the functional outcomes in the patients underwent the surgical procedure rather than in the not treated ones, particulary in lung transplant patients. Read More

Acta Otolaryngol 2018 Dec 27;138(12):1086-1091. Epub 2019 Jan 27.

d Department of Otorhinolaryngology, Head and Neck Surgery , Solingen Municipal Hospital , Solingen , Germany.

Background: In the outpatient setting in Germany, patients with rhinosinusitis usually present at general practices (GP) or ear, nose, and throat practices (ENT) for initial diagnosis and treatment.

Objectives: The aim of this study was to analyze the referral patterns of rhinosinusitis patients in GPs and ENT practices in Germany, with respect to existing recommendations.

Material And Methods: The study sample included patients from 940 GP and 106 ENT practices from Disease Analyzer database (IQVIA) who received an acute sinusitis (AS) or chronic sinusitis (CS), or nasal polyp (NP) in 2015. Read More

Eur Arch Otorhinolaryngol 2019 Jan 25. Epub 2019 Jan 25.

Department of Social Dentistry, Academic Center for Dentistry Amsterdam, University of Amsterdam and VU University, Amsterdam, The Netherlands.

Purpose: To assess awareness of, opinion about and adherence to evidence-based guidelines on chronic rhinosinusitis among Dutch Otolaryngologists.

Methods: We assessed implementation of two guidelines, one Dutch and one European, that are both intended for diagnosis and treatment of patients with chronic rhinosinusitis. We invited 485 Otolaryngologists to fill out a questionnaire and report on their opinion on and adherence to the guidelines. Read More

Asthma Res Pract 2019 18;5. Epub 2019 Jan 18.

1Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 USA.

Background: Asthma is a chronic inflammatory lung disease that affects 18.7 million U.S. Read More

Am J Rhinol Allergy 2019 Jan 24:1945892419825695. Epub 2019 Jan 24.

2 Division of Rhinology and Sinus Surgery, Department of Otolaryngology - Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina.

Background: Allergic fungal rhinosinusitis (AFRS) is characterized by higher revision endoscopic sinus surgery (ESS) rates and unique radiographic features when compared to chronic rhinosinusitis with nasal polyposis (CRSwNP) or chronic rhinosinusitis without nasal polyposis (CRSsNP).

Objective: We hypothesized that an increased frequency of concha bullosa in AFRS or other radiographic nuances might allow for accumulation of allergic mucin and contribute to increased ESS revision rates.

Methods: A retrospective cohort study was performed. Read More

Allergy Rhinol (Providence) 2019 Jan-Dec;10:2152656718821281. Epub 2019 Jan 7.

Division of Allergy and Immunology, Department of Pediatrics, Harbor UCLA Medical Center, Torrance, California.

Background: Chronic cough in children is a diagnostic challenge.

Objective: To discover the utility of nasal dipsticks and polymerase chain reaction (PCR)-DNA analysis in differentiating bacterial sinusitis from other causes of chronic cough and identifying pathogens from the nasal cavity.

Method: We recruited 22 patients under 15 years of age with cough lasting longer than 4 weeks (group 1), 7 controls with allergic rhinitis (group 2), and 10 controls without respiratory symptoms (group 3). Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Jan;33(1):14-16

Department of Otorhinolaryngology, the Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huai'an,223300,China.

To explore the correlation between peripheral blood eosinophils and tissue eosinophils in patients with chronic rhinosinusitis with nasal polyps(CRSwNP) in different periods.This trial was a prospective study involved 342 patients with CRSwNP who were treated by endoscopic sinus surgery in the Huai'an First People's Hospital, Nanjing Medical University in 2008, 2012 and 2016. Nasal polyp resection specimens were stained by HE. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Jan;33(1):9-13

Department of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital Affiliated to the Capital University of Medical Sciences,Key Laboratory Otolaryngology Head and Neck Surgery, Capital Medical University, Beijing, 100730, China.

To evaluate the differences in CRS and normal subjects between chronic rhinosinusitis without nasal polys (CRSsNP) and chronic rhinosinusitis with nasal polys (CRSwNP) in the role of TGF-β-Smad pathways in the repair of mucosal epithelium.Ethmoidal mucosal samples collected from CRS and healthy control patients were analyzed for TGF-β1, TGF-β receptorⅠ,TGF-β receptor Ⅱ, Smad3, phospho-Smad3, Smad7, and Smad anchor for receptor activation by Western blot. The proliferation of sinonasal epithelial cells at baseline after TGF-β1 and/or EGF stimulation was evaluated by the MTT assay. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Jan;33(1):5-8

Department of Otorhinolaryngology-Head and Neck Surgery,Tongji Hospital, Tongji Medical College,Huazhong University of Science and Technology,Wuhan,430022,China.

The purposes of present study were to explore the relative factors affecting treatment outcomes of chronic rhinosinusitis(CRS),and investigated the clinical manifestation changes of CRS patients after post-operative treatment of oral glucocorticoid. Forty-eight CRS subjects including 14 illness un-controlled group, and 34 illness controlled group were enrolled, and peripheral blood leukocytes, eosinophils, neutrophils, mononuclear cells, lymphocytes were detected and clinical features comprised of VAS, endoscopy and CT scan scores were recorded; 20 days'oral glucocorticoid was prescribed to the patients in illness un-controlled group and the data described above were analyzed. Compared to illness controlled group, illness uncontrolled subjects had higher peripheral blood eosinophils count(=0. Read More

Respir Med 2019 Jan 16;146:10-17. Epub 2018 Nov 16.

Pulmonary Environmental Epidemiology Unit, CNR Institute of Clinical Physiology, Via Trieste no. 41, 56126, Pisa, Italy; CNR Institute of Biomedicine and Molecular Immunology "A. Monroy", Via U. La Malfa no. 153, 90146, Palermo, Italy.

Background: Although general practitioners (GPs) are frequently the first healthcare professionals whom asthma patients refer to for their symptoms, few studies have explored the extent of adherence to guidelines for asthma management based on data provided directly by GPs. Aims of the present study were to assess drug prescriptions for asthma by GPs and to evaluate prescriptive adherence to GINA guidelines (GL) and its relationship with disease control in real life.

Methods: 995 asthmatic patients (45% males, mean age 43. Read More

Allergy Asthma Immunol Res 2019 Mar;11(2):201-211

Clinical Mucosal Immunology Study Group, Seoul, Korea.

Purpose: Endotype in chronic rhinosinusitis (CRS) has been established in the last decade. However, the exact immunologic profile of CRS still has controversy because it has a considerable immunologic heterogeneity. Therefore, we investigated various inflammatory mediators according to different nasal tissues in chronic rhinosinusitis and compared them within the same subject. Read More

Int Forum Allergy Rhinol 2019 Jan 18. Epub 2019 Jan 18.

Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of Utah, Salt Lake City, UT.

Background: Local sinonasal inflammation resulting from altered T-cell immune signaling is a contributor to the pathogenesis of chronic rhinosinusitis (CRS). CRS patients experience negative impacts on quality of life (QOL) and suffer from comorbidities linked to systemic inflammation. However, systemic inflammatory profiling to evaluate the association between systemic inflammation and QOL in CRS has not been performed. Read More

Int Forum Allergy Rhinol 2019 Jan 18. Epub 2019 Jan 18.

Department of Otolaryngology-Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, AL.

Background: Enhancing chloride (Cl ) secretion in sinus epithelia represents a novel therapeutic approach to chronic rhinosinusitis (CRS). Herbal dry extract BNO 1011 enhances mucociliary clearance (MCC) via upregulation of Cl secretion in sinonasal cultures in vitro and murine epithelium in vivo. The objective of this study is to evaluate whether the BNO 1011 improves MCC and clinical parameters in a rabbit model of CRS. Read More

J Asthma 2019 Jan 18:1-12. Epub 2019 Jan 18.

a Department of Pharmaceutical Health Outcomes and Policy, College of Pharmacy , University of Houston , TX , USA.

Objective: To evaluate the extent of documentation of asthma control and severity and associated characteristics among pediatric asthma patients in office-based settings.

Methods: This cross-sectional study utilized data from the 2012-2015 National Ambulatory Medical Care Survey (NAMCS). Patients aged 6-17 years with a diagnosis of asthma were included. Read More

Am J Rhinol Allergy 2019 Jan 18:1945892418825094. Epub 2019 Jan 18.

1 Department of Otolaryngology-Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.

Background: A remarkable relationship between upper airway conditions and lung diseases has been reported. At the same time, sinonasal findings in chronic cough patients have not been fully examined.

Objective: The purpose of this study is to show paranasal sinus findings and lung function in chronic cough patients without asthma and chest X-ray abnormalities. Read More

J Biomater Appl 2019 Jan 16:885328218822636. Epub 2019 Jan 16.

Sichuan University, West China Hospital, Department of Otolaryngology Head and Neck Surgery, Chengdu, Sichuan, China.

Background: Nasal endoscopic surgery is widely used for nasal diseases, including sinusitis and tumors. However, scar hyperplasia, nasal irritation, scab, and nasal obstruction delay nasal mucosal recovery, with prolonged cleaning exacerbating the patient's financial burden. Here, we presented a novel approach for the treatment of nasal mucosal defects, termed acellular dermal matrix. Read More

Int Arch Otorhinolaryngol 2019 Jan 24;23(1):92-100. Epub 2018 Oct 24.

Department of Pathology, Centro de Investigación y Docencia en Ciencias de la Salud (CIDOCS), Universidad Autónoma de Sinaloa, Culiacán, Sinaloa, México.

 Indolent or chronic mucormycosis is a rare entity that affects both immunosuppressed and immunocompetent individuals. Additionally, its clinical evolution is nonspecific and there is no standardized treatment for this condition.  To describe the clinical characteristics and management of patients with indolent mucormycosis. Read More

Reumatologia 2018 23;56(6):399-405. Epub 2018 Dec 23.

Clinic of Internal Medicine, Connective Tissue Diseases, and Geriatrics, Medical University of Gdańsk, Poland.

Headache is a common symptom in patients with granulomatosis with polyangiitis (GPA) mainly due to chronic sinusitis or orbital disease. Meningeal involvement may thus remain unrecognized for a long time. This can lead to a significant delay in accurate diagnosis, serious local damage of the central nervous system and high relapse rates. Read More

Int Forum Allergy Rhinol 2019 Jan 15. Epub 2019 Jan 15.

Department of Otolaryngology-Head and Neck Surgery, Rutgers New Jersey Medical School, Newark, NJ.

Background: Although some causes of rhinogenic headache, such as acute sinusitis, have clear diagnostic criteria, others, such as "sinus headache" and mucosal contact points, are more nebulous. Misdiagnosis of these entities and primary headaches may result in unnecessary medical or surgical treatment. The purpose of this systematic review is to delineate current understanding of diagnosis and treatment of rhinogenic headaches, including sinus and mucosal contact point headaches, in children. Read More

Br J Dermatol 2019 Jan 11. Epub 2019 Jan 11.

Dermatology and Allergology Department, Larrey Hospital, Toulouse University.

Dupilumab has demonstrated efficacy in atopic dermatitis (AD) , asthma , perennial allergic rhinitis and chronic sinusitis . The objectives of this prospective observational, single-centre study were to assess 1) dupilumab efficacy in real-life practice and 2) the evolution of atopic co-morbidities and specific immunoglobulin E (IgE) levels during dupilumab treatment. This article is protected by copyright. Read More

Clin Drug Investig 2019 Jan 10. Epub 2019 Jan 10.

Department of Dermatology, Fukushima Medical University, Hikarigaoka 1, Fukushima, 960-1295, Japan.

Palmoplantar pustulosis (PPP) is a chronic inflammatory disorder characterized by sterile pustules predominantly involving the palms and soles. The purpose of this review was to describe the characteristics of Japanese PPP patients as PPP is frequently observed within the Japanese population. Most Japanese dermatologists consider PPP a distinct entity, and co-existence of PPP and psoriasis is rare; however, outside Japan, PPP is often considered to be palmoplantar psoriasis, and an extra-palmoplantar lesion associated with PPP is considered to be psoriasis. Read More

Int Forum Allergy Rhinol 2019 Jan 10. Epub 2019 Jan 10.

Department of Otolaryngology-Head and Neck Surgery, Vanderbilt University School of Medicine, Nashville, TN.

Background: It is hypothesized that uncontrolled inflammation is responsible for many of the manifestations and symptoms of chronic rhinosinusitis (CRS). Although earlier work has demonstrated an association between olfactory loss and mucus cytokines, the impact on other symptoms is unknown. In this study we investigated the relationship between cytokines, inflammatory cell counts, and patient-reported outcomes measures to better understand how the inflammatory microenvironment correlates with CRS symptomatology. Read More

Int Forum Allergy Rhinol 2019 Jan 10. Epub 2019 Jan 10.

Department of Otorhinolaryngology-Head & Neck Surgery, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX.

Background: Balloon sinus dilation (BSD) is a commonly performed sinus procedure in the United States. Several cadaveric studies have evaluated BSD accuracy and the maxillary sinus has consistently been shown to be the most challenging to cannulate. We designed an independent study to evaluate the intraoperative accuracy of maxillary sinus BSD. Read More

J Dermatol 2019 Jan 10. Epub 2019 Jan 10.

Department of Dermatology, Gifu University Graduate School of Medicine, Gifu, Japan.

Health Sci Rep 2018 Aug 12;1(8):e52. Epub 2018 Jul 12.

Department of Clinical Microbiology Rigshospitalet Denmark.

Background: Chronic lung infection with is the main cause of mortality in patients with cystic fibrosis (CF). Sinus colonization with P. aeruginosa often precedes intermittent lung colonization, and intermittent colonization precedes chronic infection. Read More

Int Forum Allergy Rhinol 2019 Jan 8. Epub 2019 Jan 8.

Department of Otolaryngology-Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China.

Background: Odontogenic sinusitis (OS) presents more satisfactory therapeutic effect after endoscopic surgery compared with chronic rhinosinusitis (CRS) of other origin. The aim of the present study was to investigate the clinical characteristics, morphological features, and epithelial barrier function of sinus mucosa of OS and discuss the possible relationship with good prognosis.

Methods: A total of 25 subjects with OS, 7 CRS without nasal polyps (CRSsNP), 10 CRS with nasal polyps (CRSwNP), and 9 control subjects were recruited. Read More

Transl Res 2018 Dec 19. Epub 2018 Dec 19.

Department of Surgery - Otolaryngology Head and Neck Surgery, The Queen Elizabeth Hospital, University of Adelaide, Woodville South, South Australia, Australia. Electronic address:

Pseudomonas aeruginosa (PA) is a bacterial pathogen that frequently displays antibiotic resistance. Its presence within the sinuses of chronic rhinosinusitis sufferers is associated with poorer quality of life. Obligately lytic bacteriophages (phages) are viruses that infect, replicate within, and lyse bacteria, causing bacterial death. Read More

Laryngoscope 2019 Jan 6. Epub 2019 Jan 6.

Vanderbilt University School of Medicine, Otolaryngology & Head and Neck Surgery, Nashville, Tennessee, U.S.A.

Objectives: Recent increases in opioid-related mortality have prompted a critical evaluation of postoperative pain management across all specialties. However, successfully limiting narcotic overprescription requires perioperative identification of patients who are at risk for high postoperative pain. Unfortunately, quality data to guide practice patterns are lacking. Read More

Ann Thorac Surg 2018 Oct 26. Epub 2018 Oct 26.

Division of Cardiothoracic Surgery, Department of Surgery. Electronic address:

Kartagener's syndrome is a rare genetic disorder of ciliated epithelial cells associated with recurrent respiratory tract infections, bronchiectasis, and situs inversus. In some patients the accumulation of airway secretions and recurrent infections lead to end-stage lung disease, for which lung transplantation (LT) is the only effective treatment. Anatomical variations, such as dextrocardia and pulmonary situs inversus, make the procedure challenging, yet feasible with certain technical modifications and careful preparation of donor lungs. Read More

Int Forum Allergy Rhinol 2019 Jan 4. Epub 2019 Jan 4.

Department of Otorhinolaryngology, Gyeongsang National University School of Medicine and Gyeongsang National University Hospital, Jinju, Republic of Korea.

Background: Medialization of the middle turbinate (MT) is an effective technique to prevent recurrent rhinosinusitis but could, in theory, reduce olfactory function by interfering the odorants to reach the olfactory mucosae. We performed a prospective randomized double-blind trial under the hypothesis that olfactory functions would be affected by the status of olfactory mucosae, not by MT medialization.

Methods: In randomly selected sides, the unilateral MT was medialized in 80 patients undergoing bilateral endoscopic sinus surgery for chronic rhinosinusitis. Read More