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Int J Surg Case Rep 2022 Jun 6;96:107280. Epub 2022 Jun 6.

Department of Otolaryngology-Head and Neck Surgery, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.

Introduction And Importance: Foreign bodies in paranasal sinuses are rarely encountered and most commonly present in the maxillary sinus. Guidelines for managing paranasal sinus object removal are limited due to its rarity. However, there are three major management options: open surgery, endoscopic sinus surgery, and observation. Read More

J Immunol Res 2022 14;2022:2273121. Epub 2022 Jun 14.

Department of Otolaryngology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

The pathogenesis of CRSwNP is complex and unclear. CRSwNP is subdivided into two types based on the infiltration of EOSs: eCRSwNP and noeCRSwNP. This study was designed to seek the role of autophagy, mitophagy, and Akt/mTOR pathway in these two subtypes of CRSwNP. Read More

Int J Mol Sci 2022 Jun 9;23(12). Epub 2022 Jun 9.

MML Centre, Bagno 2, 00-112 Warsaw, Poland.

  is an opportunistic pathogen found in the healthy human skin microbiome bacterial community that is able to cause infections of diverse localization, manifestation, and course, including laryngological infections, such as necrotizing sinusitis. Chronic maxillary sinusitis is a disease present in up to one third of European and American populations, and its etiology is not fully described. Within this study, we aimed to characterize 18 strains recovered from maxillary sinuses and evaluate them as etiological agents of chronic disease. Read More

Int J Environ Res Public Health 2022 Jun 14;19(12). Epub 2022 Jun 14.

Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Ostrava, 708 52 Ostrava, Czech Republic.

Although extensive research has shown the pathological effect of fine and ultrafine airborne particles, clear evidence of association of environmental exposure to them and inflammatory changes in human nasal mucosa is missing. Meanwhile, pathogenesis of chronic rhinosinusitis, despite being a disease with high prevalence in the population, is still unclear. The increasing evidence of the pro-inflammatory properties of these particles raises the question of their possible role in chronic rhinosinusitis. Read More

Biomedicines 2022 Jun 13;10(6). Epub 2022 Jun 13.

Department of Otolaryngology, Head and Neck Surgery, Wroclaw Medical University, Borowska 213, 50-556 Wroclaw, Poland.

In chronic upper respiratory tract diseases, increased cell proliferative activity is observed, which is coordinated by BCL-2 proteins and small non-coding RNAs. This study aimed to determine the expression of critical apoptosis markers at the mRNA and miRNA levels in patients with chronic rhinosinusitis with nasal polyps (CSRwNP). The study group consisted of ten patients with CSRwNP and ten healthy subjects. Read More

Int Arch Allergy Immunol 2022 Jun 23:1-11. Epub 2022 Jun 23.

Department of Otolaryngology/Head and Neck Surgery, Ninth School of Clinical Medicine, Peking University, Beijing, China.

Background: Chronic rhinosinusitis (CRS) is a common condition in otorhinolaryngology. It is characterized by chronic inflammation of the nasal cavity and the sinus mucosa. However, its specific pathogenesis remains unclear. Read More

J Craniofac Surg 2022 May;33(3):886-888

Department of Otolaryngology-Head and Neck Surgery, Kosin University College of Medicine, Busan, South Korea.

Background And Objectives: Headache is a common symptom with etiologies that are difficult to distinguish, 1 of which is sinusitis. A solitary sphenoid lesion, which is rare, can also cause acute or chronic headaches. The authors investigated whether endoscopic sinus surgery (ESS) for solitary sphenoid lesions could reduce headache symptoms. Read More

Int J Immunopathol Pharmacol 2022 Jan-Dec;36:3946320221109529

Department of Otorhinolaryngology, 74566The First Affiliated Hospital of Soochow University, Suzhou, China.

Eosinophilic chronic rhinosinusitis (ECRS) is a chronic inflammatory disease characterized by prominent eosinophilic infiltration along with a T-helper-2 (Th2) response. It has been well documented that signal transducer and activator of transcription 6 (STAT6) is a nuclear transcription factor that mediates Th2-type immunity and is implicatory of STAT1 and STAT3 in the pathogenesis of allergic airway diseases. However, little is known about the association between STATs and ECRS. Read More

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2022 Jun;57(6):783-788

Department of Otorhinolaryngology Head and Neck Surgery, the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510630, China.

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2022 Jun;57(6):778-782

Department of Otorhinolaryngology Head and Neck Surgery, Affiliated Hospital of Nantong University, Institute of Otorhinolaryngology Head and Neck Surgery, Affiliated Hospital of Nantong University, Nantong 226001, China.

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2022 Jun;57(6):692-698

Department of Otorhinolaryngology Head and Neck Surgery, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.

To preliminarily analyze the expression of angiotensin-converting enzyme 2 (ACE2) and to investigate its potential regulatory mechanism in chronic rhinosinusitis with nasal polyps (CRSwNP). Patients underwent nasal endoscopic surgery in the Third Affiliated Hospital of Sun Yat-sen University from February 2020 to May 2021 were selected, including 17 males and 6 females, aging from 23 to 66 years old. Expression of ACE2 was evaluated via immunohistochemical staining in controls with non-chronic rhinosinusitis, non-eosinophilic CRSwNP (non-ECRSwNP), and eosinophilic CRSwNP (ECRSwNP) tissue, respectively. Read More

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2022 Jun;57(6):683-691

Department of Otorhinolaryngology Head and Neck Surgery, Capital Institute of Pediatrics, Beijing 100020, China.

To explore the relationship between pathogens in the olfactory cleft area and olfactory disorders in patients with upper respiratory inflammation (URI) during the prevention and control of 2019 novel coronavirus disease (COVID-19). A total of 234 URI patients including acute upper respiratory infection, chronic rhinosinusitis (CRS), allergic rhinitis (AR) were continuously selected from September 2020 to March 2021 in Beijing Anzhen Hospital and 98 healthy adults were enrolled as controls. The secretions from the olfactory cleft of all subjects were collected with nasal swabs under nasal endoscopy. Read More

Eur Arch Otorhinolaryngol 2022 Jun 20. Epub 2022 Jun 20.

Department of Otorhinolaryngology, Antalya Training and Research Hospital, Antalya, Turkey.

Purpose: The current studies in the literature report that periostin contributes to the formation of nasal polyps and may be a molecular biomarker for chronic rhinosinusitis with nasal polyps (CRSwNP). This study aims to investigate the effect of periostin in determining polyp burden in CRSwNP patients and evaluate its impact on postoperative surgical results and its functionality as a biomarker.

Methods: The study included 26 patients who underwent endoscopic sinus surgery due to CRSwNP and 30 patients who were scheduled to undergo septoplasty due to isolated nasal septum deviation. Read More

OTO Open 2022 Apr-Jun;6(2):2473974X221105277. Epub 2022 Jun 13.

Department of Otolaryngology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Objective: This review aimed to systematically determine the optimal nasal saline regimen for different types of sinonasal diseases.

Data Sources: PubMed, Embase, SCOPUS, Cochrane Library, Web of Science, ClinicalTrials.gov. Read More

Front Immunol 2022 3;13:803097. Epub 2022 Jun 3.

Department of Otolaryngology, Guangzhou Key Laboratory of Otorhinolaryngology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by heterogeneous inflammatory endotypes of unknown etiology. Invariant natural killer T (iNKT) cells are multifunctional innate T cells that exhibit Th1-, Th2-, and Th17-like characteristics. We investigated functional relationships between iNKT cells and inflammatory subtypes of CRSwNP. Read More

Cureus 2022 May 11;14(5):e24922. Epub 2022 May 11.

Otolaryngology, MercyOne North Iowa Medical Center, Mason City, USA.

Pott's puffy tumor (PPT) is a localized forehead swelling with underlying subperiosteal abscess formation and osteomyelitis of the frontal bone. It is a rare complication of frontal sinusitis, and it is especially rare in adult females. A careful review of existing literature identified only 17 cases in adult females. Read More

Zhonghua Yi Xue Za Zhi 2022 May;102(20):1533-1536

Department of Neurology, the Second Hospital of Hebei Medical University, Shijiazhuang 050000, China.

The current study summarized the clinical characteristics of 8 patients with central nervous system anaerobic infections who visited the Second Hospital of Hebei Medical University from June 2019 to June 2021. Among the 8 patients, 7 cases had headache and fever as the first symptoms, and 1 case had left-sided limb weakness as the first symptom. Four patients had a previous history of diabetes (1 patient had a history of tooth extraction before the onset of the disease), 1 patient had a previous history of sinusitis, 1 patient had a history of tooth extraction before the onset of the disease, and 2 patients had chronic extensive periodontitis or periapical periodontitis. Read More

J Otolaryngol Head Neck Surg 2022 Jun 11;51(1):25. Epub 2022 Jun 11.

Department of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, 10073, China.

Background: The conventional belief that glucocorticosteroid (GC) acts through a single brand glucocorticoid receptor (GR)α protein has changed dramatically with the discovery of multiple GR isoforms. We aimed to evaluate whether multiple GR protein isoforms are expressed in chronic rhinosinusitis with nasal polyps (CRSwNP) and whether GR protein isoform expression profiles differ between different endotypes of CRSwNP.

Methods: Thirty-eight patients with CRSwNP and ten healthy volunteers were included. Read More

Sci Rep 2022 Jun 10;12(1):9554. Epub 2022 Jun 10.

Department of Otorhinolaryngology, Hospital Medicine Center, Seoul National University Hospital, 101, Daehak-ro, Jongno-gu, Seoul, 03080, South Korea.

This study aimed to evaluate the relationship between chronic rhinosinusitis (CRS) and proton pump inhibitor (PPI) use in a Korean population. The Korea National Health Insurance Service-National Sample Cohort was assessed from 2002 to 2013. Patients with CRS (n = 7194) and control participants (n = 28,776) were matched by random order at a 1:4 ratio for age, sex, income group, region of residence, and index date. Read More

J Allergy Clin Immunol Pract 2022 Jun;10(6):1472-1473

IDIBAPS, Barcelona, Spain.

Int J Mol Sci 2022 Jun 4;23(11). Epub 2022 Jun 4.

Laboratoire Inflammation Tissus Epithéliaux et Cytokines (LITEC), UR15560, Université de Poitiers, 86000 Poitiers, France.

Chronic rhinosinusitis with nasal polyps (CRSwNP) is associated with inflammation and tissue remodeling including myofibroblasts differentiation and extracellular matrix (ECM) deposition mediated by TGF-β1 and IL-4. Oncostatin M (OSM) is a cytokine involved in fibrotic processes in other cellular subtypes. We investigated the mechanisms of action of OSM in the fibrosis process associated with CRSwNP. Read More

Ann Allergy Asthma Immunol 2022 Jun 4. Epub 2022 Jun 4.

Department of Medicine - University of Virginia, Charlottesville, Virginia; Department of Microbiology - University of Virginia, Charlottesville, Virginia.

Objective: Specific antibody deficiency is an immune deficiency defined by the presence of normal quantitative levels of immunoglobulins but impaired antibody responses to polysaccharide antigens in patients presenting with frequent otosinopulmonary infections with pyogenic bacteria. This review summarizes the pitfalls associated with defining exactly what constitutes an "impaired" antibody response to polysaccharide antigens and the importance of documenting actual pyogenic infections before making a diagnosis of an immune deficiency.

Data Sources: PubMed review using the following words: specific antibody deficiency, pneumococcal vaccination, salmonella vaccination, infectious sinusitis Study Selection: This review focused on key studies that have been utilized to define what constitutes a "normal" humoral immune response to pneumococcal and salmonella vaccination in healthy subjects as well as published papers defining current expert opinion. Read More

Int Forum Allergy Rhinol 2022 Jun 7. Epub 2022 Jun 7.

Division of Rhinology/Skull Base Surgery, Department of Otolaryngology-Head and Neck Surgery , Vanderbilt University School of Medicine, Nashville, TN, USA.

Background: Inflammatory patterns in chronic rhinosinusitis (CRS) may predict disease severity, need for multiple sinus surgeries, and treatment response. This study analyzes nasal mucus inflammatory cytokine patterns in patients with (CRSwNP) and without (CRSsNP) nasal polyposis and their association with revision sinus surgery.

Methods: A total of 319 CRS patients who underwent sinus surgery were included. Read More

Eur Arch Otorhinolaryngol 2022 Jun 6. Epub 2022 Jun 6.

Upper Airway Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, Ghent, Belgium.

Objective: To evaluate the time for recovery of the sense of smell in patients with CRSwNP who underwent Reboot surgery compared to patients undergoing ESS in a long-term follow-up study.

Methods: Data were collected retrospectively from 168 patients with severe uncontrolled CRSwNP, who underwent revision surgery, either as Extended Endoscopic Sinus Surgery (Reboot, 140 patients) or as regular Endoscopic Sinus Surgery (ESS, 28 patients) between January 1, 2014, and December 31, 2015, aiming to compare the outcome of surgeries after 2 years of follow-up. Sense of smell was scored as judged by the patient using scores 0 to 3 reflecting a percentage estimate of remaining smell. Read More

Drugs Real World Outcomes 2022 Jun 3. Epub 2022 Jun 3.

Department of Paediatrics, Medical Centre Leeuwarden, Leeuwarden, The Netherlands.

Background: Intranasal corticosteroids are one of the cornerstone treatment options for allergic rhinitis and chronic sinusitis complaints. Safety information in the summary of product characteristics may not be representative for observations in daily clinical practice. The Netherlands Pharmacovigilance Center (Lareb) collects post-marketing safety information, using spontaneous reporting systems. Read More

World Neurosurg 2022 May 30. Epub 2022 May 30.

Department of Otolaryngology (ENT)/Head and Neck Surgery, Antalya Training and Research Hospital, Antalya, TURKEY. Electronic address:

Background: We evaluated the frequency of nasal pathologies and the significance of surgical access to the sellar region in patients who underwent an operation for sellar mass using the endonasal and microscopic transsphenoidal approaches.

Material And Methods: We retrospectively evaluated all patients who underwent surgery for pituitary macroadenoma using microscopic (n = 78) and endonasal (n = 20) transsphenoidal approaches. Patients' epicrisis, preoperative, and postoperative imaging, as well as their operative notes were reviewed. Read More

Cureus 2022 Apr 29;14(4):e24597. Epub 2022 Apr 29.

Medicine and Surgery, Taibah University, Madinah, SAU.

Background Chronic rhinosinusitis (CRS) is a chronic inflammation of the sinonasal mucosa that is clinically associated with sinus pressure, nasal congestion, rhinorrhea, and a decreased sense of smell that lasts more than 12 weeks. Endoscopic sinus surgery (ESS) for medically refractory CRS is mainly undergone to improve sinus function and access to topical medicinal treatments. However, olfactory changes after ESS can be unpredictable. Read More

Einstein (Sao Paulo) 2022 27;20:eAO6800. Epub 2022 May 27.

Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.

Objective: To analyze telemedicine diagnostic accuracy in patients with respiratory infections during COVID-19 pandemic compared to face-to-face evaluation in the emergency department.

Methods: Randomized, unicentric study between September 2020 and November 2020 in patients with any respiratory symptom (exclusion criteria: age >65 years, chronic heart or lung diseases, immunosuppressed). Patients were randomized 1:1 for brief telemedicine followed by face-to-face consultation or direct face-to-face evaluation. Read More

Otolaryngol Head Neck Surg 2022 May 31:1945998221102810. Epub 2022 May 31.

Department of Otolaryngology-Head and Neck Surgery, School of Medicine, Indiana University Indianapolis, Indiana, USA.

Objective: Despite extensive research into chronic rhinosinusitis (CRS) epidemiology, presentation, and outcomes, there is scant knowledge on sex-specific differences. The objective of this study was to identify differences between male and female patients with CRS in baseline disease severity at presentation, choice for surgery vs continued medical treatment, and postoperative response.

Study Design: We evaluated data on demographic and health characteristics, clinical objective disease measures, and sinus-specific and general health patient-reported outcome measures. Read More

Am J Otolaryngol 2022 Jul-Aug;43(4):103471. Epub 2022 May 5.

University of California, Davis, Department of Otolaryngology, Sacramento, CA, United States of America. Electronic address:

Purpose: The purpose of this study is to characterize deficits in olfactory-specific and sinonasal-specific QoL after total laryngectomy (TL) with validated patient reported outcome measures.

Methods: Thirty patients who had a TL were prospectively enrolled. Patient demographics, as well as scores from the Questionnaire of Olfactory Disorders Negative Statements (QOD-NS) and the Sino-nasal Outcome Test-22 (SNOT-22) were collected. Read More