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Allergy 2021 Apr 30. Epub 2021 Apr 30.

Department of Surgery-Otolaryngology Head and Neck Surgery, Basil Hetzel Institute for Translational Health Research, Central Adelaide Local Health Network, Woodville South, Australia.

Staphylococcus aureus is a pathogen of major concern in both acute infections as well as chronic conditions such as chronic rhinosinusitis (CRS). Bacteriophage (phage) therapy has been considered in Western countries as early as the 1920s and has recently regained interest for its potential to treat infections caused by antibiotic resistant strains including Methicillin Resistant Staphylococcus aureus (MRSA). However, bacteria can adapt and become resistant to phages. Read More

Turk Arch Otorhinolaryngol 2021 Mar 26;59(1):33-42. Epub 2021 Mar 26.

Institute of Pharmacy, Military Medical Academy Faculty of Medicine, University of Defence, Belgrade, Serbia.

Objective: To assess the effects and adverse events of preparation Sinulan forte containing extracts of five medicinal plants in comparison to mometasone furoate nasal spray (MFNS) in therapy of acute postviral rhinosinusitis (APRS).

Methods: We included 46 APRS patients in this prospective investigation and randomized to two groups. The patients in group 1 (n=23) received MFNS 200 μg two times/day for ten days, and patients in group 2 (n=23) received Sinulan forte, tablets 225 mg per os, two times/day also for ten days. Read More

Can J Respir Ther 2021 21;57:44-48. Epub 2021 Apr 21.

Pediatric Intensive Care Unit, Children's Damascus University Hospital, Damascus, Syria.

Kartagener syndrome is a rare, autosomal recessive genetic disorder that causes defects in the action of ciliary movement, comprises of triad situs inversus, chronic sinusitis, and bronchiectasis. We present the case of a 3-year-old boy with repeated respiratory infections and pneumonic infections presenting with acute respiratory failure. He was diagnosed with Kartagener syndrome based on his clinical presentation and imaging features. Read More

BMJ Case Rep 2021 Apr 27;14(4). Epub 2021 Apr 27.

General Medicine, Nitte University K S Hegde Medical Academy, Mangalore, Karnataka, India.

A middle-aged woman with diabetes presented with left-sided facial pain, complete ptosis and fever of short duration. On presentation, she had hyperglycaemia without ketosis. There was total ophthalmoplegia of the left eye with a visual acuity of 6/36. Read More

Indian J Med Microbiol 2021 Apr 24. Epub 2021 Apr 24.

Department of ENT, Christian Medical College, Vellore, 632004, India. Electronic address:

Purpose: To determine the association between antifungal susceptibility test (AFST) results and in vivo therapeutic response in Indian patients with fungal rhinosinusitis.

Methods: The clinicoradiological, fungal culture, AFST, histopathology results and outcomes of 48 patients with fungal rhinosinusitis seen between 20132015 were analysed. Minimum inhibitory concentration (MIC) determination was performed for amphotericin B, itraconazole, voriconazole and posaconazole. Read More

J Patient Cent Res Rev 2021 19;8(2):86-97. Epub 2021 Apr 19.

Department of Medicine, University of Chicago, Chicago, IL.

Purpose: Given the current life expectancy and number of individuals living with Down syndrome (DS), it is important to learn common occurrences of disease conditions across the developmental lifespan. This study analyzed data from a large cohort of individuals with DS in an effort to better understand these disease conditions, inform future screening practices, tailor medical care guidelines, and improve utilization of health care resources.

Methods: This retrospective, descriptive study incorporated up to 28 years of data, compiled from 6078 individuals with DS and 30,326 controls matched on age and sex. Read More

Front Neurol 2021 8;12:606617. Epub 2021 Apr 8.

French Center for Pediatric Stroke, Pediatric Neurology Department, APHP University Hospital Necker-Enfants Malades, Paris, France.

Neurologic manifestations associated with Covid-19 are increasingly reported, especially stroke and acute cerebrovascular events. Beyond cardiovascular risk factors associated with age, some young adults without medical or cardiovascular history had stroke as a presenting feature of Covid-19. Suggested stroke mechanisms in this setting are inflammatory storm, subsequent hypercoagulability, and vasculitis. Read More

OTO Open 2021 Jan-Mar;5(1):2473974X211002547. Epub 2021 Mar 11.

Department of Otolaryngology-Head and Neck Surgery, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.

Objective: The purpose of this study is to identify perioperative independent prognostic factors that are available to the consulting team to aid in determining prognosis in patients with acute invasive fungal sinusitis.

Study Design: Retrospective chart review of patients with biopsy-proven acute invasive fungal sinusitis from 2015 to 2018.

Setting: Academic tertiary care center. Read More

JAMA Netw Open 2021 03 1;4(3):e212713. Epub 2021 Mar 1.

Department of Internal Medicine, Albany Medical College, Albany, New York.

Importance: Acute bacterial sinusitis is common, but currently recommended antibiotic treatment provides minimal benefit.

Objective: To confirm the previous finding that high-dose amoxicillin plus clavulanate (with double the amount of amoxicillin) may be superior to standard-dose amoxicillin plus clavulanate in adults.

Design, Setting, And Participants: This double-blind, comparative-effectiveness randomized clinical trial was conducted from February 26, 2018, through May 10, 2020, at the academic primary care internal medicine and pediatrics practice of Albany Medical Center, located in Cohoes, New York. Read More

Acta Otorhinolaryngol Ital 2021 Feb;41(1):43-50

Department of Otolaryngology, San Luigi Gonzaga Hospital, University of Turin, Orbassano, Turin, Italy.

Objectives: The purpose of this study was to correlate acute invasive fungal rhinosinusitis (AIFRS) and chronic invasive fungal rhinosinusitis with underlying diseases, aetiological microorganisms, clinical symptoms, radiological findings, and surgical and medical treatment to determine the subset of patients who require more accurate diagnostic investigation and to prevent irreversible complications.

Methods: This retrospective monocentric study included 17 patients who underwent endoscopic sinus surgery evaluated by paranasal computed tomography and magnetic resonance imaging. Age, sex and symptoms, and location of the invasive fungal infection and the causative fungus were analysed. Read More

Vestn Otorinolaringol 2021 ;86(1):108-111

Research Clinical Institute of Otorinolaryngology named after. L.I. Sverzhevsky, Moscow, Russia.

The Aim Of The Study: Was to summarize data on the role and place of herbal remedies, in particular, the extract from the roots of (EPs 7630) in the treatment of acute sinusitis.

Material And Methods: Materials of scientific publications included in the Cochrane Library, information bases of the RSCI, MEDLINE, PubMed were used as a data source. The choice of material was carried out according to the keywords: epidemiology of acute sinusitis, modern treatment of acute sinusitis, colds, herbal remedies, . Read More

Vestn Otorinolaringol 2021 ;86(1):46-50

Perinatal Center, Khabarovsk, Russia.

In an open, randomized prospective comparative clinical study in parallel groups of patients with a diagnosis of acute respiratory infection, acute rhinosinusitis, 107 children aged 4-5 years took part. The purpose of this study was to compare the effectiveness of various treatment regimens for acute viral rhinosinusitis in children. We compared the treatment effectiveness of acute viral rhinosinusitis using the herbal medicine Sinupret in the form of oral drops, standard treatment and standard treatment supplemented with topical antibacterial drugs. Read More

Ter Arkh 2020 Dec 15;92(12):155-159. Epub 2020 Dec 15.

Kuban State Medical University.

Aim: To evaluate the clinical efficacy of Polydexa with phenylephrinum in the complex treatment of moderate acute bacterial rhinosinusitis.

Materials And Methods: The article presents the results of a clinical study of 100 patients with moderate acute bacterial rhinosinusitis 37 (37%) men, 63 (63%) women aged 15 to 53 years. The patients were randomized into 2 groups of 50 people each. Read More

Respir Investig 2021 May 26;59(3):270-290. Epub 2021 Feb 26.

Tokyo Women's Medical University, Japan.

Cough and sputum are common complaints at outpatient visits. In this digest version, we provide a general overview of these two symptoms and discuss the management of acute (up to three weeks) and prolonged/chronic cough (longer than three weeks). Flowcharts are provided, along with a step-by-step explanation of their diagnosis and management. Read More

Am J Rhinol Allergy 2021 Feb 23:1945892421994999. Epub 2021 Feb 23.

Department of Otolaryngology-Head and Neck Surgery, University of Louisville, Louisville, Kentucky.

Background Objective Study Design: RARS is a challenging clinical problem that impacts many patients. This article seeks to systematically review the literature on RARS management.

Methods: Cochrane, PubMed, EMBASE, and other databases were queried for articles related to RARS dating from 1990 to present, according to PRISMA guidelines. Read More

Laryngoscope Investig Otolaryngol 2021 Feb 21;6(1):25-33. Epub 2020 Dec 21.

Institute for Medical Research, Division of Clinical and Experimental Immunology, Military Medical Academy Faculty of Medicine University of Defence Belgrade Serbia.

Background: Previous investigations suggest the use of extract from the roots of (EPs 7630) for the therapy of uncomplicated rhinosinusitis. The aim of this prospective study was to compare the effects of herbal drug EPs 7630 and antibiotic roxithromycin on chemokine production in nasal mucosa and clinical parameters in patients with uncomplicated acute bacterial rhinosinusitis (ABRS).

Methods: Seventy-eight ABRS patients were divided into 26 patients receiving EPs 7630 tablets, 3 × 20 mg/day per os (group 1), 26 patients receiving roxithromycin tablets, 2 × 150 mg/day per os (group 2), both for 10 days, and 26 patients who received no therapy (Control group). Read More

Childs Nerv Syst 2021 Feb 17. Epub 2021 Feb 17.

Department of Neurosurgery, Fundación Santafé de Bogotá, Carrera 7 No. 117 - 15, Bogotá, Colombia.

The vein of Galen malformation is caused by an abnormal shunting between choroidal arteries and the median prosencephalic vein during embryological development, leading to increased blood flow to the deep cerebral veins, intracranial damage, and systemic repercussions. Idiopathic spontaneous thrombosis of a vein of Galen malformation is rare, and its association with acute sinusitis has not been reported in the literature. We present the case of a girl with a postnatal diagnosis of a vein of Galen malformation at the age of 16 months, with secondary pulmonary hypertension that was adequately controlled with spironolactone. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2021 Feb;35(2):125-130

Department of Otorhinolaryngology Head and Neck Surgery，Yantai Yuhuangding Hospital，Qingdao University，Yantai，264000，China.

The aim of this study is to explore the diagnosis, clinical manifestations and surgical treatment experience of acute sinusitis complicated with orbital subperiosteal abscess. The clinical data of 11 patients with acute sinusitis complicated by orbital subperiosteal abscess from 1 year and 8 months to 50 years were retrospectively analyzed, including clinical manifestations, imaging manifestations, bacteriological examinations, surgical methods and therapeutic effects. All patients were given antibacterial drugs, glucocorticoids, and surgery. Read More

Vestn Otorinolaringol 2020 ;85(6):46-51

Central State Medical Academy of Department of Presidential Affairs, Moscow, Russia.

The number of cases of acute bacterial rhinosinusitis (ABRS) in our country tends to increase. According to clinical guidelines of the Ministry of Health of the Russian Federation, nasal catheter drainage is used to treat ABRS, but not all ENT-doctors use this method in daily practice. Many of them use it empirically and obtain good results. Read More

Biomed Phys Eng Express 2020 09 8;6(5):055003. Epub 2020 Sep 8.

Department of Otolaryngology, Head and Neck Surgery, Hyogo Prefectural Amagasaki General Medical Center, 6608550 Higashinaniwachou 2-17-77 Hyogo Prefecture, Japan.

Objective: To investigate the association between subjective pain intensity and objective parameters obtained from two autonomic function tests in a longitudinal study targeting acute pain model in otolaryngology-head and neck region: pupillary light reflex (PLR) and heart rate variability (HRV).

Approach: We enrolled 35 patients with acute otolaryngology-head and neck region inflammatory disorders at pre-treatment stage. The acute inflammatory disorders were defined as acute tonsillitis, peritonsillar abscess, acute epiglottitis, acute sinusitis, and deep neck space abscess. Read More

Ann Otol Rhinol Laryngol 2021 Jan 13:3489420987969. Epub 2021 Jan 13.

Department of Otolaryngology-Head and Neck Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

Introduction: Frontal sinusitis in the pediatric population is a disease that has not been thoroughly studied or characterized. The goals of this study are to characterize the clinical presentation, radiologic variables, treatment modalities, complications, and prognosis associated with acute and chronic frontal sinus disease in the pediatric population.

Methods: IRB-approved retrospective cohort study of pediatric patients who were diagnosed with acute (AFS) or chronic frontal sinusitis (CFS) and underwent frontal sinus surgery at a tertiary level Children's Hospital from 2006 to 2016. Read More

Eur Heart J Case Rep 2020 Oct 6;4(5):1-6. Epub 2020 Oct 6.

Department of Cardiac Surgery, Ghent University Hospital, Corneel Heymanlaan 10, 9000 Ghent, Belgium.

Background: Granulomatosis with polyangiitis (GPA), formerly known as Wegener's granulomatosis, is a systemic inflammatory process predominantly affecting upper and lower respiratory tract and kidneys. Valvular heart disease is a rare manifestation of GPA.

Case Summary: We report two cases of acute valvular heart disease mimicking acute endocarditis caused by GPA. Read More

Int J Pediatr Otorhinolaryngol 2021 Jan 3;140:110542. Epub 2020 Dec 3.

Augusta University, Department of Otolaryngology- Head and Neck Surgery, Augusta, Georgia, USA. Electronic address:

Background: There remains variation in management of orbital complications of acute bacterial rhinosinusitis (ABRS); specifically, those subperiosteal abscesses that present without immediate surgical indication. Recent systematic reviews on management and proposed treatment algorithms are helpful but do not consider the financial implications for healthcare systems and patients.

Methods: A retrospective chart review of pediatric patients from a tertiary care children's hospital between 2002 and 2020 was performed, identifying patients via ICD coding corresponding to acute bacterial sinusitis and orbital involvement classified as Chandler 3 confirmed by contrasted computed tomography (CT). Read More

Int Forum Allergy Rhinol 2020 Dec 4. Epub 2020 Dec 4.

Department of Otolaryngology and Communication Sciences, SUNY Upstate Medical University, Syracuse, NY.

Ophthalmic Plast Reconstr Surg 2021 Mar-Apr 01;37(2):e40-e80

Department of Ophthalmology.

Acute invasive fungal rhinosinusitis is a rare, although highly morbid, infection primarily affecting immunosuppressed individuals. The same population is at particularly high risk of complications and mortality in the setting of SARS-CoV-2 infection and coronavirus disease 2019 (COVID-19)-related acute respiratory distress syndrome. The authors present a case of acute invasive fungal rhino-orbital mucormycosis in a patient with COVID-19 and discuss the prevalence, diagnosis, and treatment of fungal coinfections in COVID-19. Read More

Allergy 2021 03 29;76(3):789-803. Epub 2020 Nov 29.

Department of Otolaryngology, Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China.

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) entry factors, ACE2 and TMPRSS2, are highly expressed in nasal epithelial cells. However, the association between SARS-CoV-2 and nasal inflammation in chronic rhinosinusitis with nasal polyps (CRSwNP) has not been investigated. We thus investigated the expression of SARS-CoV-2 entry factors in nasal tissues of CRSwNP patients, and their associations with inflammatory endotypes of CRSwNP. Read More

J Drug Assess 2020 Nov 4;9(1):145-150. Epub 2020 Nov 4.

Institute for Medical Research, Division of Clinical and Experimental Immunology, Military Medical Academy Faculty of Medicine, University of Defense, Belgrade, Serbia.

Objective: Previous investigations suggest the use of extract from the roots of (EPs 7630) for improvement of the symptoms of uncomplicated upper airway inflammations, due to its antimicrobial and immunomodulatory actions. The aim of this investigation was to evaluate the effects of EPs 7630 on chemokine production in nasal mucosa and clinical parameters of patients with acute postviral rhinosinusitis (APRS).

Methods: Twenty-six ( = 26) APRS patients and 25 ( = 25) control subjects were included in this prospective study. Read More

Vestn Otorinolaringol 2020 ;85(5):40-43

National Medical Research Center of Otorhinolaryngology of the Federal Medical and Biological Agency, Moscow, Russia.

The purpose of the study was to summarize data on modern antibiotic therapy for acute sinusitis, the role and place of topical antibacterial drugs, in particular Fluimucil-Antibiotic, in modern treatment strategies for this disease.

Methods: Search in the PUBMED electronic database (articles and related abstracts) for the keywords «acute sinusitis", «antibiotics», «thiamphenicol glycinate acetylcysteine» «biofilm», «respiratory tract infection», «N-acetylcysteine».

Results: The published research results indicate the high antibacterial activity of the Fluimucil-Antibiotic, in particular, for the topical drug use in the form of inhalations, applications, irrigation, and instillations. Read More

Infect Chemother 2020 09 18. Epub 2020 Sep 18.

Department of Laboratory Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.

is a mold in phylum Basidiomycota and is an uncommon human pathogen. Sinusitis and allergic bronchopulmonary mycosis are the two major diseases caused by . Although there have been several reports of invasive fungal diseases, most of them were invasive sinusitis. Read More

Cureus 2020 Aug 29;12(8):e10106. Epub 2020 Aug 29.

Infectious Diseases, Rutgers New Jersey Medical School, Newark, USA.

Pott's puffy tumor, typified by a subperiosteal abscess underlying the frontal bone, is an uncommonly encountered clinical entity that can occur in the setting of local trauma or secondary to frontal sinusitis. Diagnosis can be challenging, as cultures may be sterile, and the condition must be differentiated from neoplasm and superficial and soft tissue infection. Although more common in the pediatric population, Pott's puffy tumor must remain on the differential with a high index of suspicion in adult patients who fit the clinical picture. Read More