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Fungal Rhinosinusitis: Unravelling the Disease Spectrum.

Authors:
Virendra Singh

J Maxillofac Oral Surg 2019 Jun 28;18(2):164-179. Epub 2019 Jan 28.

Department of Oral and maxillofacial Surgery, PGIDS, Pt. BD Sharma University of Health Sciences, Rohtak, Haryana 124001 India.

Fungal rhinosinusitis (FRS), once considered a rare disease, has seen a steep rise in incidence in recent times. This global rise in the burden of fungal disease is a consequence of an increment in the population with weakened immune systems. Increased life expectancy with rise in conditions like diabetes mellitus, medical advancements with invasive interventions, use of immunosuppressive drugs and chemo-radiotherapy all lead to unique risk situations. Read More

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http://link.springer.com/10.1007/s12663-018-01182-w
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http://dx.doi.org/10.1007/s12663-018-01182-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441414PMC
June 2019
2 Reads

Antibiotic prescription among outpatients in a prefecture of Japan, 2012-2013: a retrospective claims database study.

BMJ Open 2019 Apr 3;9(4):e026251. Epub 2019 Apr 3.

Division of General Internal Medicine, Jichi Medical University Hospital, Shimotsuke, Tochigi, Japan.

Objectives: To investigate oral antibiotic prescribing patterns and identify factors associated with antibiotic prescriptions, with the aim of guiding future interventions to reduce inappropriate prescribing.

Design: Retrospective cohort study.

Setting: Database of public health insurance claims in Kumamoto prefecture (Japan). Read More

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http://dx.doi.org/10.1136/bmjopen-2018-026251DOI Listing
April 2019
2 Reads

Recurrent periorbital cellulitis associated with rhinosinusitis in children: Characteristics, course of disease, and management paradigm.

Int J Pediatr Otorhinolaryngol 2019 Feb 25;121:26-28. Epub 2019 Feb 25.

Department of Otolaryngology Head and Neck Surgery, Rabin Medical Center and Schneider Children's Hospital, Petah Tikva, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Background: Recurrent periorbital cellulitis (RPOC) associated with rhinosinusitis is rarely noted and scarcely discussed in the literature. The aim of our study was to analyze the characteristics and disease course of a group of pediatric patients with RPOC.

Methods: The medical records of all pediatric patients with a diagnosis of RPOC treated in a tertiary children's hospital were retrieved. Read More

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http://dx.doi.org/10.1016/j.ijporl.2019.02.037DOI Listing
February 2019
1 Read

Bronchodilators, Antibiotics, and Oral Corticosteroids Use in Primary Care for Children With Cough.

Glob Pediatr Health 2019 25;6:2333794X19831296. Epub 2019 Feb 25.

New York Medical College, Valhalla, NY, USA.

Real-world management decisions for acute cough in children in primary care practice are not well understood. This study is an analysis of 560 encounters for children with cough, 19 days to 18 years of age, seen in a predominantly suburban academic pediatric practice, over 1 year. Past history, cough duration, and cough characteristics significantly affected treatment decisions. Read More

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http://dx.doi.org/10.1177/2333794X19831296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390215PMC
February 2019
1 Read

Duration of antibiotic treatment for common infections in English primary care: cross sectional analysis and comparison with guidelines.

BMJ 2019 02 27;364:l440. Epub 2019 Feb 27.

Modelling and Economics Unit, National Infection Service, Public Health England, London NW9 5EQ, UK.

Objective: To evaluate the duration of prescriptions for antibiotic treatment for common infections in English primary care and to compare this with guideline recommendations.

Design: Cross sectional study.

Setting: General practices contributing to The Health Improvement Network database, 2013-15. Read More

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http://dx.doi.org/10.1136/bmj.l440DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391655PMC
February 2019
2 Reads

Results of endoscopic nasal surgery in the treatment of invasive fungal sinusitis in children with cancer and immunosuppression.

Acta Otorrinolaringol Esp 2019 Feb 14. Epub 2019 Feb 14.

Departamento de Otorrinolaringología, Centro Clínico de Cabeza y Cuello, Ciudad de Guatemala, Guatemala.

Background And Objective: to describe the results of the treatment of invasive fungal sinusitis with nasal endoscopic surgery in an immunocompromised paediatric oncological population.

Methods: retrospective study of all patients diagnosed with invasive fungal sinusitis operated in the National Paediatric Oncology Unit between 2012 and 2016. Data taken from their medical history included: epidemiological characteristics, oncological diagnosis, haematological data, symptoms, tomographic studies, surgical interventions, results of pathology and cultures, medications received, complications, evolution and survival. Read More

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http://dx.doi.org/10.1016/j.otorri.2018.09.001DOI Listing
February 2019
3 Reads

Recurrent myocardial infarction in a 50-year-old woman.

Heart 2019 Feb 14. Epub 2019 Feb 14.

University Hospital Hairmyres, East Kilbridge, UK.

CLINICAL INTRODUCTION: A 50-year-old woman presented with an inferoposterior ST-elevation myocardial infarction (STEMI) and underwent emergency percutaneous coronary intervention (PCI). Angiography revealed acute occlusion of the circumflex and right coronary (RCA) arteries. PCI was uncomplicated. Read More

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http://heart.bmj.com/lookup/doi/10.1136/heartjnl-2018-314114
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http://dx.doi.org/10.1136/heartjnl-2018-314114DOI Listing
February 2019
5 Reads

A rare case of septic cavernous sinus thrombosis as a complication of sphenoid sinusitis.

Ci Ji Yi Xue Za Zhi 2019 Jan-Mar;31(1):63-65

Department of Pediatrics, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.

Isolated sphenoid sinusitis is a rare disorder and may present with severe complications due to its proximity to the orbital and intracranial areas. We report a 13-year-old boy hospitalized for septic shock with fever of unknown origin. Facial palsy was later noted. Read More

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http://dx.doi.org/10.4103/tcmj.tcmj_1_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334571PMC
January 2019
3 Reads

Use of Dipstick Assay and Rapid PCR-DNA Analysis of Nasal Secretions for Diagnosis of Bacterial Sinusitis in Children With Chronic Cough.

Allergy Rhinol (Providence) 2019 Jan-Dec;10:2152656718821281. Epub 2019 Jan 7.

Division of Allergy and Immunology, Department of Pediatrics, Harbor UCLA Medical Center, Torrance, California.

Background: Chronic cough in children is a diagnostic challenge.

Objective: To discover the utility of nasal dipsticks and polymerase chain reaction (PCR)-DNA analysis in differentiating bacterial sinusitis from other causes of chronic cough and identifying pathogens from the nasal cavity.

Method: We recruited 22 patients under 15 years of age with cough lasting longer than 4 weeks (group 1), 7 controls with allergic rhinitis (group 2), and 10 controls without respiratory symptoms (group 3). Read More

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http://dx.doi.org/10.1177/2152656718821281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327234PMC
January 2019
2 Reads

Outpatient Antibiotic Prescribing for Acute Respiratory Infections During Influenza Seasons.

JAMA Netw Open 2018 Jun 1;1(2):e180243. Epub 2018 Jun 1.

Centers for Disease Control and Prevention, Atlanta, Georgia.

Importance: Acute respiratory infections (ARIs) are the syndrome for which antibiotics are most commonly prescribed; viruses for which antibiotics are ineffective cause most ARIs.

Objectives: To characterize antibiotic prescribing among outpatients with ARI during influenza season and to identify targets for reducing inappropriate antibiotic prescribing for common ARI diagnoses, including among outpatients with laboratory-confirmed influenza.

Design, Setting, And Participants: Cohort study enrolling outpatients aged 6 months or older with ARI evaluated at outpatient clinics associated with 5 US Influenza Vaccine Effectiveness Network sites during the 2013-2014 and 2014-2015 influenza seasons. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2018.0243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324415PMC
June 2018
5 Reads

Rhinogenic headache in pediatric and adolescent patients: an evidence-based review.

Int Forum Allergy Rhinol 2019 Jan 15. Epub 2019 Jan 15.

Department of Otolaryngology-Head and Neck Surgery, Rutgers New Jersey Medical School, Newark, NJ.

Background: Although some causes of rhinogenic headache, such as acute sinusitis, have clear diagnostic criteria, others, such as "sinus headache" and mucosal contact points, are more nebulous. Misdiagnosis of these entities and primary headaches may result in unnecessary medical or surgical treatment. The purpose of this systematic review is to delineate current understanding of diagnosis and treatment of rhinogenic headaches, including sinus and mucosal contact point headaches, in children. Read More

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http://doi.wiley.com/10.1002/alr.22268
Publisher Site
http://dx.doi.org/10.1002/alr.22268DOI Listing
January 2019
11 Reads

Daily outpatient intravenous antibiotic therapy for the management of paediatric periorbital cellulitis, a retrospective case series.

Clin Otolaryngol 2019 Jan 14. Epub 2019 Jan 14.

Department of Otolaryngology, McGill University, Montreal, Quebec, Canada.

Objective: To evaluate whether outpatient treatment of periorbital cellulitis with daily administration of intravenous antibiotics and physician evaluation is an effective and safe alternative to admission.

Design: A retrospective chart review study of paediatric patients treated on an outpatient basis for periorbital cellulitis at a tertiary children's hospital between 2013 and 2015 was performed. Children were assessed day by a paediatrician to monitor for resolution of symptoms or complications. Read More

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http://dx.doi.org/10.1111/coa.13284DOI Listing
January 2019
9 Reads

Inpatient Mortality After Endoscopic Sinus Surgery for Invasive Fungal Rhinosinusitis.

Ann Otol Rhinol Laryngol 2019 Apr 25;128(4):300-308. Epub 2018 Dec 25.

2 Division of Otolaryngology - Head and Neck Surgery, University of California, San Diego, San Diego, CA, USA.

Objectives:: Invasive fungal rhinosinusitis is a rare, life-threatening condition that affects the paranasal sinuses. The standard of care after diagnosis includes surgical debridement and aggressive medical management. Despite treatment, mortality remains unacceptably high. Read More

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http://dx.doi.org/10.1177/0003489418820871DOI Listing
April 2019
3 Reads

Case report of Actinomyces turicensis meningitis as a complication of purulent mastoiditis.

BMC Infect Dis 2018 Dec 20;18(1):686. Epub 2018 Dec 20.

Semmelweis University, Institute of Medical Microbiology, Budapest, Hungary.

Background: Central nervous system (CNS) infections caused by Actinomyces spp. including brain abscess, actinomycoma, subdural empyema and epidural abscess are well described, however reports of Actinomyces-associated meningitis are scarcely reported.

Case Report: We present the case of a 43-year-old Hungarian male patient with poor socioeconomic status who developed acute bacterial meningitis caused by Actinomyces turicensis originating from the left side mastoiditis. Read More

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http://dx.doi.org/10.1186/s12879-018-3610-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302302PMC
December 2018
8 Reads

Fungal infections of the central nervous system and paranasal sinuses in onco-haematologic patients. Epidemiological study reporting the diagnostic-therapeutic approach and outcome in 89 cases.

Mycoses 2019 Mar 22;62(3):252-260. Epub 2019 Jan 22.

Istituto di Ematologia, Polo Onco-Ematologico Fondazione Policlinico A. Gemelli-IRCCS, Università Cattolica del Sacro Cuore, Roma, Italy.

Invasive fungal infections (IFI) of the Central Nervous System (IFI-CNS) and Paranasal Sinuses (IFI-PS) are rare, life-threatening infections in haematologic patients, and their management remains a challenge despite the availability of new diagnostic techniques and novel antifungal agents. In addition, analyses of large cohorts of patients focusing on these rare IFI are still lacking. Between January 2010 and December 2016, 89 consecutive cases of Proven (53) or Probable (36) IFI-CNS (71/89) and IFI-PS (18/89) were collected in 34 haematological centres. Read More

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http://dx.doi.org/10.1111/myc.12884DOI Listing
March 2019
4 Reads

Antibiotic prescriptions to adults with acute respiratory tract infections by Italian general practitioners.

Infect Drug Resist 2018 8;11:2199-2205. Epub 2018 Nov 8.

Department of Health Sciences, Medical School, University of Catanzaro "Magna Græcia", Catanzaro, Italy,

Purpose: The overuse, misuse, and underuse of antimicrobial agents often lead to the spread of antibiotic-resistant microorganisms. The aim of our study was to describe the pattern of antibiotic prescriptions for acute respiratory tract infections (RTIs) among the adult population and the factors associated with antibiotic prescribing.

Patients And Methods: The study involved patients who visited a general practitioner with suspected acute RTI. Read More

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https://www.dovepress.com/antibiotic-prescriptions-to-adults
Publisher Site
http://dx.doi.org/10.2147/IDR.S170349DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233949PMC
November 2018
16 Reads

Current indications for balloon sinuplasty.

Curr Opin Otolaryngol Head Neck Surg 2019 Feb;27(1):7-13

Rhinology & Endoscopic Skull Base Surgery, UCLA Department of Head & Neck Surgery, Los Angeles, California, USA.

Purpose Of Review: The purpose of the review is to evaluate the current indications and contraindications for balloon sinuplasty and review the clinical trials performed in this area.

Recent Findings: The indications for balloon sinus dilatation are somewhat similar to those for endoscopic sinus surgery. Balloon sinus ostial dilation (BSD) has been found to be most effective in the treatment of recurrent acute sinusitis (RARS) and chronic rhinosinusitis without nasal polyposis (CRSsNP) that has been refractory to medical therapy. Read More

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http://dx.doi.org/10.1097/MOO.0000000000000506DOI Listing
February 2019
9 Reads

Nasal septal abscess: a 10-year retrospective study.

Eur Arch Otorhinolaryngol 2019 Feb 30;276(2):417-420. Epub 2018 Nov 30.

Department of Otolaryngology-Head and Neck Surgery, Tri-Service General Hospital, National Defense Medical Center, No. 325, Cheng-Kung Road Section 2, Taipei 114, Taiwan, ROC.

Objective: Nasal septal abscess is an uncommon condition but it can cause potentially life-threatening intracranial complications and cosmetic nasal deformity.

Methods: We analyzed ten years of cases to determine the optimal diagnostic and therapeutic modalities. A retrospective review of case notes from Tri-Service General Hospital archives was performed. Read More

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http://link.springer.com/10.1007/s00405-018-5212-0
Publisher Site
http://dx.doi.org/10.1007/s00405-018-5212-0DOI Listing
February 2019
16 Reads

In-office balloon sinus dilation versus medical therapy for recurrent acute rhinosinusitis: a randomized, placebo-controlled study.

Int Forum Allergy Rhinol 2019 Feb 19;9(2):140-148. Epub 2018 Nov 19.

The Sinus & Respiratory Disease Center at the Texas Institute, Dallas, TX.

Background: A limited number of studies have demonstrated symptomatic improvement for recurrent acute rhinosinusitis (RARS) patients after endoscopic sinus surgery. In this randomized, controlled study we evaluated 24-week outcomes for balloon sinus dilation (BSD) performed in-office (IO) with medical management (MM) as compared with MM only for RARS patients.

Methods: Adults diagnosed with RARS were randomized to groups with BSD plus MM (n = 29) or MM alone (n = 30). Read More

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http://dx.doi.org/10.1002/alr.22248DOI Listing
February 2019
14 Reads

Variation in Outpatient Antibiotic Dispensing for Respiratory Infections in Children by Clinician Specialty and Treatment Setting.

Pediatr Infect Dis J 2018 Dec;37(12):1248-1254

Medical and Clinical Pharmacy Policy, Anthem, Inc, Chicago, Illinois.

Background: Antibiotics are commonly prescribed for children with acute respiratory infections (ARIs). This study describes the distribution of ARI diagnoses and specifically quantifies antibiotic dispensing for bronchitis and upper respiratory infection (URI) by treatment setting and specialty.

Methods: This retrospective, observational cross-sectional study used data from the HealthCore Integrated Research Environment containing claims from 14 commercial health plans for 2012 to 2014. Read More

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http://dx.doi.org/10.1097/INF.0000000000002004DOI Listing
December 2018
11 Reads

Sinonasal debridement versus no debridement for the postoperative care of patients undergoing endoscopic sinus surgery.

Cochrane Database Syst Rev 2018 11 8;11:CD011988. Epub 2018 Nov 8.

Department of Otolaryngology - Head and Neck Surgery, Rabin Medical Center, Petah Tikva, Israel.

Background: Endoscopic sinus surgery (ESS) is often recommended for symptomatic patients with recurrent acute or chronic rhinosinusitis who have failed conservative treatment. Postoperative care has been felt to be critical for both maintaining the surgical patency of the operated sinuses and improving patient symptoms. Debridement of the sinonasal cavities is one such postoperative care measure that has frequently been studied in the literature, often with conflicting conclusions. Read More

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http://doi.wiley.com/10.1002/14651858.CD011988.pub2
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http://dx.doi.org/10.1002/14651858.CD011988.pub2DOI Listing
November 2018
20 Reads

ACR Appropriateness Criteria Sinusitis-Child.

J Am Coll Radiol 2018 Nov;15(11S):S403-S412

Specialty Chair, Riley Hospital for Children Indiana University, Indianapolis, Indiana.

Sinusitis is common in children that usually resolves spontaneously. Imaging is not part of the standard of care for initial diagnosis, however may be necessary in cases with persistent or chronic sinusitis to guide surgical intervention, or to rule out intracranial and vascular complications of sinusitis. Computed tomography (CT) and magnetic resonance imaging (MRI) are the leading imaging modalities. Read More

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http://dx.doi.org/10.1016/j.jacr.2018.09.029DOI Listing
November 2018
3 Reads

Practical Strategies for Management of Lenalidomide-Associated Cytopenias in Myelodysplastic Syndromes With del(5q).

J Adv Pract Oncol 2017 Nov-Dec;8(7):721-728. Epub 2017 Nov 1.

H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.

A male patient aged 67 years with a 2-year history of refractory anemia and myelodysplastic syndromes (MDS) with del(5q) started lenalidomide (Revlimid) treatment as a participant in the MDS-001 trial (List et al., 2005). At the time of the study, this patient had been transfusion-dependent since 2001, and at study entry he had received a total of 12 units of red blood cells (RBCs). Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188096PMC
November 2017
1 Read

Retrobulbar optic neuropathy associated with sphenoid sinus mucormycosis.

Neurol Clin Neurosci 2018 Sep 10;6(5):146-147. Epub 2018 Jul 10.

Department of Neurology JA Toride Medical Center Toride Ibaraki Japan.

Because fungi usually spread from the paranasal sinuses to the orbital apex in invasive fungal sinusitis (IFS), IFS often presents as an orbital apex syndrome (OAS) characterized by dysfunction of cranial nerves II, III, IV, V1, and VI. We report a case of sphenoid sinus mucormycosis that presented as isolated retrobulbar optic neuropathy. A 94-year-old woman presented with acute blindness in the right eye. Read More

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http://dx.doi.org/10.1111/ncn3.12216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175081PMC
September 2018
3 Reads

Perioperative Risk Factors Associated With Morbidity and Mortality Following Pediatric Inpatient Sinus Surgery.

Ann Otol Rhinol Laryngol 2019 Jan 17;128(1):13-21. Epub 2018 Oct 17.

4 Department of Anesthesiology, University of California, San Diego, La Jolla, CA, USA.

Objectives:: Pediatric sinus surgery is indicated for a wide range of sinonasal and skull base pathologies, but it is most commonly performed for recalcitrant chronic rhinosinusitis or complicated acute sinusitis. The authors aim to report medical risk factors of morbidity and mortality following inpatient sinus surgery in the pediatric population.

Methods:: Using data from the Kids' Inpatient Database from 2003 to 2012, patients with International Classification of Diseases, Ninth Revision, procedure codes for primary sinus surgery were identified. Read More

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http://dx.doi.org/10.1177/0003489418805504DOI Listing
January 2019
12 Reads

Physiotherapy in postinfection injury to cranial nerves III, IV, and VI: a case study.

Am J Phys Med Rehabil 2018 Oct 8. Epub 2018 Oct 8.

Department of Rehabilitation, Medical University of Warsaw, ul. Księcia Trojdena 2c, 02-091 Warsaw, Poland Department of Neurology, Medical University of Warsaw, ul. Stefana Banacha 1a, 02-097 Warsaw, Poland Department of Rehabilitation, Public Central Teaching Clinical Hospital, ul. Stefana Banacha 1a, 02-097 Warsaw, Poland Department of Rehabilitation, Józef Piłsudski University of Physical Education in Warsaw, ul. Marymoncka 34, 00-968 Warsaw, Poland 2nd Department of Clinical Radiology, Medical University of Warsaw, ul. Stefana Banacha 1a, 02-097 Warsaw, Poland Department of Otorhinolaryngology, Medical University of Warsaw, ul. Stępińska 19/25, 00-739 Warsaw, Poland.

The patient with bacterial infection sequelae in the form of damage to cranial nerves (CN) III, IV, and VI was followed-up. He had exhibited clinical and radiographic signs of paranasal sinusitis. Prior to his physiotherapy, the patient received standard treatment with natural and synthetic antibiotics and steroids. Read More

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http://dx.doi.org/10.1097/PHM.0000000000001060DOI Listing
October 2018
17 Reads

Intraorbital and Intracranial Complications of Acute Rhinosinusitis: A Rare Case Report.

Iran J Otorhinolaryngol 2018 Sep;30(100):301-304

Department of Otorhinolaryngology, All India Institute of Medical Sciences, Bhubaneswar ,Odisha ,India.

Introduction: Complications of acute sinusitis affecting multiple sites are very uncommon in the antibiotic era. However, a significant proportion of patients (5-40%) suffering from acute sinusitis can have these complications mostly due to the delayed diagnosis of the disease. Patients can have variable presentations according to the site and extent of the infection. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147267PMC
September 2018
3 Reads

Variability in Antibiotic Prescribing for Upper Respiratory Illnesses by Provider Specialty.

J Pediatr 2018 12 5;203:76-85.e8. Epub 2018 Sep 5.

Tufts Medical Center, Division of Geographic Medicine and Infectious Diseases, Boston, MA; Tufts University School of Medicine, Boston, MA.

Objective: To evaluate variation in antibiotic prescribing between pediatric and nonpediatric providers for common upper respiratory illnesses.

Study Design: Patient encounters for children aged <18 years from a regional health care system were identified. Electronic medical records from 2011 to 2016 were extracted for diagnoses of upper respiratory infection, pharyngitis, acute otitis media, and sinusitis. Read More

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http://dx.doi.org/10.1016/j.jpeds.2018.07.044DOI Listing
December 2018
6 Reads

Practice Patterns of Systemic Corticosteroid Use in Complicated Acute Rhinosinusitis Among Rhinologists and Pediatric Otolaryngologist.

Am J Rhinol Allergy 2018 Nov 30;32(6):485-490. Epub 2018 Aug 30.

1 Department of Otolaryngology, SUNY Downstate Medical Center, Brooklyn, New York.

Background: The use of systemic corticosteroids remains controversial in the treatment of orbital complications of sinusitis.

Objective: To compare and contrast the current practice patterns of the use of systemic corticosteroid in the management of orbital complications of acute bacterial rhinosinusitis (ABRS) among fellowship-trained members of American Society of Pediatric Otolaryngology (ASPO) and American Rhinologic Society (ARS).

Study Design: Cross-sectional survey. Read More

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http://dx.doi.org/10.1177/1945892418797056DOI Listing
November 2018
27 Reads

Intracranial complications of pediatric sinusitis: Identifying risk factors associated with prolonged clinical course.

Int J Pediatr Otorhinolaryngol 2018 Sep 12;112:10-15. Epub 2018 Jun 12.

Rady Children's Hospital San Diego, Otolaryngology, San Diego, CA, USA; Department of Surgery, University of California San Diego, San Diego, CA, USA.

Objective: Intracranial extension is one of the most serious and morbid complications of pediatric sinusitis. Managing this complication continues to be challenging even after widespread pneumococcal vaccination adoption. We aim to identify risk factors associated with complicated clinical courses, and to assess for altering microbial communities and increased antibiotic resistance. Read More

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http://dx.doi.org/10.1016/j.ijporl.2018.06.019DOI Listing
September 2018
4 Reads

Chronic rhinosinusitis exacerbations are differentially associated with lost productivity based on asthma status.

Rhinology 2018 Dec;56(4):323-329

Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, MA, USA.

Background: The frequency of chronic rhinosinusitis (CRS) exacerbations is an independent predictor of quality of life. The objective of this study was to evaluate if increased CRS exacerbations predict decreased productivity.

Methods: Cross-sectional study of adult CRS patients. Read More

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http://dx.doi.org/10.4193/Rhin18.033DOI Listing
December 2018
3 Reads

Cyclamen europaeum improves the effect of oral antibiotics on exacerbations and recurrences of chronic rhinosinusitis: a real-life observational study (CHRONOS).

Acta Otorhinolaryngol Ital 2018 Apr;38(2):115-123

Rhinology Unit and Smell Clinic, ENT Department, Hospital Clínic & Clinical and Experimental Respiratory Immunoallergy, IDIBAPS& CIBERES. Barcelona, Catalonia, Spain.

Summary: Chronic rhinosinusitis (CRS) is an inflammatory disease of the nose and paranasal sinuses affecting 11% of the European population. Cyclamen europaeum plant extract (CE) has demonstrated efficacy in treating acute rhinosinusitis, but its role in CRS exacerbations remains unknown. In this real-life, prospective, epidemiological, observational study, a total of 317 patients with exacerbations of CRS without nasal polyps (CRSsNP) of moderate severity were treated using three different options: oral antibiotics, CE extract nasal spray, or the combination of oral antibiotic with CE extract. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028819PMC
http://dx.doi.org/10.14639/0392-100X-1342DOI Listing
April 2018
8 Reads

Prevalence and Predictors of Invasive Fungal Infections in Children with Persistent Febrile Neutropenia Treated for Acute Leukemia - A Prospective Study.

Indian J Pediatr 2018 Dec 29;85(12):1090-1095. Epub 2018 Jun 29.

Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, 110029, India.

Objective: To ascertain the prevalence of invasive fungal infections (IFI), predictors of IFI, identify etiological species and outcome (mortality/discharge) in persistent febrile neutropenia in children with acute leukemia.

Methods: It was a prospective, observational study conducted from January 2013 through June 2014 in a tertiary care centre in New Delhi. Children between 1 and 12 y of age, on chemotherapy for acute leukemia with persistent febrile neutropenia (> 96 h) were enrolled. Read More

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http://dx.doi.org/10.1007/s12098-018-2722-0DOI Listing
December 2018
152 Reads
0.920 Impact Factor

Infectious disease burden and antibiotic prescribing in primary care in Israel.

Ann Clin Microbiol Antimicrob 2018 Jun 9;17(1):26. Epub 2018 Jun 9.

The Faculty of Medicine in the Galilee, Bar Ilan University, Zefat, Israel.

Background: Antibiotics are frequently prescribed at many of the visits to primary care clinics, often for conditions for which they provide no benefit, including viral respiratory tract infections.

Objectives: The aim was to evaluate primary care visits due to infectious diseases, and to estimate antibiotic prescribing and antibiotic dispensing by pharmacies.

Methods: Diagnosis of infectious disease, antibiotic prescribing and dispensing data at the individual patient level were extracted for 2015 from Clalit Health Services' electronic medical records and linked to determine the condition for which the antimicrobial was prescribed. Read More

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http://dx.doi.org/10.1186/s12941-018-0278-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5994243PMC
June 2018
21 Reads

Epidemiology and risk factors for invasive fungal infections during induction chemotherapy for newly diagnosed acute myeloid leukemia: A retrospective cohort study.

PLoS One 2018 8;13(6):e0197851. Epub 2018 Jun 8.

Division of Infection Disease, Department of Internal Medicine, China Medical University Hospital, Taichung City, Taiwan, R.O.C.

This study investigated the epidemiology and risk factors associated with invasive fungal infections (IFIs) during induction chemotherapy in a cohort of Taiwanese patients with newly-diagnosed acute myeloid leukemia (AML). IFIs are a significant complication in the management of immunocompromised cancer patients; such infections are associated with a high incidence of morbidity and mortality, particularly in many South-Asian countries, where IFI rates are increasing. We retrospectively analyzed IFI incidence data from 105 patients with newly diagnosed AML at a single center undergoing their first course of induction chemotherapy without primary antifungal prophylaxis between November 2008 and December 2014. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0197851PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993235PMC
December 2018
2 Reads

Intracranial complications of acute sinusitis in children: The role of endoscopic sinus surgery.

Int J Pediatr Otorhinolaryngol 2018 Jul 11;110:147-151. Epub 2018 May 11.

University of Texas Southwestern Medical Center Department of Otolaryngology, United States; Children's Medical Center Dallas, United States.

Objective: To study the role of endoscopic sinus surgery (ESS) in the management of intracranial complications of children with acute rhinosinusitis METHODS: Retrospective chart review at a tertiary care pediatric hospital MAIN OUTCOMES: Demographics, intracranial complications, length of hospital stay (LOS), neurological sequelae, ESS, neurosurgical procedures RESULTS: Twenty-four children with a mean age (SD) of 12.9 years (+/-3.2) with an intracranial complication(s) of acute rhinosinusitis were identified between 2005-2016. Read More

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http://dx.doi.org/10.1016/j.ijporl.2018.05.015DOI Listing
July 2018
6 Reads

Management of pediatric orbital cellulitis: A systematic review.

Int J Pediatr Otorhinolaryngol 2018 Jul 8;110:123-129. Epub 2018 May 8.

Department of Otolaryngology, Boston University School of Medicine, 4th Floor, FGH Building, 820 Harrison Ave., Boston, MA 02118, United States. Electronic address:

Objectives: Orbital complications account for 74-85% of all complications from acute sinusitis, more often affect the pediatric population, and can result in devastating consequences. Therefore these patients require prompt diagnosis and proper management. We review and summarize the current literature to determine the appropriate management of each stage of pediatric orbital cellulitis and offer a new comprehensive literature-based algorithm. Read More

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http://dx.doi.org/10.1016/j.ijporl.2018.05.006DOI Listing
July 2018
3 Reads

The Utility of Polyether-Ether-Ketone Implants Adjacent to Sinus Cavities After Craniofacial Trauma.

J Oral Maxillofac Surg 2018 Nov 10;76(11):2361-2369. Epub 2018 May 10.

Associate Professor, Division of Plastic, Maxillofacial, and Oral Surgery, Department of Surgery, Duke University, Durham, NC. Electronic address:

Purpose: Polyether-ether-ketone (PEEK) implants have become increasingly popular for use in reconstructive procedures. It is imperative to understand the consequences of using this biomaterial in anatomic sites that can pose a risk of infection. Specifically, the use of PEEK in paranasal sinus cavity reconstruction is not well documented. Read More

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http://dx.doi.org/10.1016/j.joms.2018.05.002DOI Listing
November 2018
1 Read

Pituitary Abscess: A Rare Clinical Entity in the Presence of Acute Rhinosinusitis: A Case Report.

J Neurol Surg Rep 2018 Apr 25;79(2):e36-e40. Epub 2018 May 25.

Department of Surgery - Otolaryngology Head & Neck Surgery, University of Florida College of Medicine - Jacksonville, Jacksonville, Florida, United States.

A pituitary abscess is an often-overlooked diagnosis in the clinical presentation of a sellar mass. Due to its rare incidence and nonspecific presentation, diagnosis and treatment is often delayed. The authors describe a 56-year-old male patient presenting with acute onset of severe headache, visual field deficit, and radiologic findings of an expansile sellar lesion. Read More

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http://dx.doi.org/10.1055/s-0038-1656531DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5969996PMC
April 2018
4 Reads

[Clinical research of different characteristics of fungal ball sinusitis].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Feb;32(3):220-224

Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, and Key Laboratory of Otolaryngology Head and Neck Surgery (Capital Medical University), Ministry of Education, Beijing, 100730, China.

The aim of this study is to investigate the clinical features of different subtypes of fungal ball sinusitis. Four hundred and forty-nine cases with fungal ball rhinosinusitis (FBS) were involved in this retrospective analysis. The clinical features including symptoms, signs, and imaging scans, pathological results were all collected for each patient and the patients were classified into different subtypes according to these clinical features and the follow-up treatment. Read More

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http://dx.doi.org/10.13201/j.issn.1001-1781.2018.03.016DOI Listing
February 2018
11 Reads

Factors Predictive of Postoperative Acute Respiratory Failure Following Inpatient Sinus Surgery.

Ann Otol Rhinol Laryngol 2018 Jul 16;127(7):429-438. Epub 2018 May 16.

3 Department of Anesthesiology, University of California, San Diego, San Diego, California, USA.

Objective: The impact of perioperative risk factors on outcomes following outpatient sinus surgery is well defined; however, risk factors and outcomes following inpatient surgery remain poorly understood. We aimed to define risk factors of postoperative acute respiratory failure following inpatient sinus surgery.

Methods: Utilizing data from the Nationwide Inpatient Sample Database from the years 2010 to 2014, we identified patients (≥18 years of age) with an Internal Classification of Disease, Ninth Revision, Clinical Modification (ICD-9-CM) procedure code of sinus surgery. Read More

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http://dx.doi.org/10.1177/0003489418775129DOI Listing
July 2018
16 Reads

Implication of fraction of exhaled nitric oxide and blood eosinophil count in severe asthma.

Allergol Int 2018 Sep 10;67S:S3-S11. Epub 2018 May 10.

Department of Respiratory Medicine, Saitama Medical University, Saitama, Japan; Allergy Center, Saitama Medical University, Saitama, Japan.

Background: Severe asthma is a complex disease with heterogeneous features and involves type 2 airway inflammation, including eosinophil accumulation. Surrogate biomarkers, fraction of exhaled nitric oxide (FeNO) and blood eosinophil count (b-EOS), may predict eosinophilic airway inflammation. Here we investigated clinical characteristics of severe asthma phenotype using a combined analysis of FeNO and b-EOS. Read More

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http://dx.doi.org/10.1016/j.alit.2018.04.003DOI Listing
September 2018
6 Reads

Cyclamen europaeum extract for acute sinusitis.

Cochrane Database Syst Rev 2018 May 11;5:CD011341. Epub 2018 May 11.

Department of Family Medicine, Beilinson Hospital, Rabin Medical Center, 39 Jabotinski Street, Petah Tikva, Israel, 49100.

Background: Acute sinusitis is a common reason for primary care encounters. It causes significant symptoms including facial pain, congested nose, headache, thick nasal mucus, fever, and cough and often results in time off work or school. Sinusitis treatment focuses on eliminating causative factors and controlling the inflammatory and infectious components. Read More

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http://dx.doi.org/10.1002/14651858.CD011341.pub2DOI Listing
May 2018
4 Reads

High-dose versus standard-dose amoxicillin/clavulanate for clinically-diagnosed acute bacterial sinusitis: A randomized clinical trial.

PLoS One 2018 8;13(5):e0196734. Epub 2018 May 8.

Departments of Medicine and Pediatrics, Albany Medical College, Albany, NY, United States of America.

Background: The recommended treatment for acute bacterial sinusitis in adults, amoxicillin with clavulanate, provides only modest benefit.

Objective: To see if a higher dose of amoxicillin will lead to more rapid improvement.

Design, Setting, And Participants: Double-blind randomized trial in which, from November 2014 through February 2017, we enrolled 315 adult outpatients diagnosed with acute sinusitis in accordance with Infectious Disease Society of America guidelines. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0196734PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940197PMC
August 2018
9 Reads

Miliary Tuberculosis Presenting With Meningitis in a Patient Treated With Mycophenolate for Lupus Nephritis: Challenges in Diagnosis and Review of the Literature.

J Investig Med High Impact Case Rep 2018 Jan-Dec;6:2324709618770226. Epub 2018 Apr 18.

Maimonides Medical Center, Brooklyn, NY, USA.

Tuberculosis is one of the top 10 causes of death worldwide according to the World Health Organization. Central nervous system involvement is usually the least common presentation of tuberculosis occurring in about 1% of all cases but yet can have very devastating outcomes. Lupus nephritis is one of the most common complications of systemic lupus erythematosus with up to two thirds of patients presenting with some degree of renal dysfunction. Read More

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http://dx.doi.org/10.1177/2324709618770226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5912272PMC
April 2018
5 Reads

[The specific features of the clinical course and the treatment strategy in the children presenting with viral sinusitis].

Vestn Otorinolaringol 2018;83(2):42-45

N.I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, Moscow, Russia, 117997; Morozovskzya City Children's Clinical Hospital, Moscow Health Department, Moscow, Russia, 111049.

The objective of the present study was to elucidate the peculiar features of acute viral and bacterial sinusitis in the children and to elaborate the algorithm for their treatment based on the results of the primary clinical and laboratory examination. As many as 224 children at the age varying from 1-17 years suffering from acute sinusitis were enrolled in the study. The following methods were employed for the purpose of the study; the analysis of the medical histories of the patients, general examination by an otorhinolaryngologist, diagnostic endoscopy of the nasal cavity and nasopharynx, radiological studies and computed tomography of the paranasal sinuses, echosinusoscopy, the comprehensive microbiological and virological investigation, and evaluation of the peripheral blood characteristics. Read More

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http://dx.doi.org/10.17116/otorino201883242-45DOI Listing
September 2018

Rhinitis and Sinusitis in the Geriatric Population.

Otolaryngol Clin North Am 2018 Aug 19;51(4):803-813. Epub 2018 Apr 19.

Department of Head and Neck Surgery, UCLA, 200 UCLA Medical Plaza, Suite 550, Los Angeles, CA 90095, USA. Electronic address:

Rhinitis and sinusitis are common medical conditions that affect the geriatric population and have a significant impact on their quality of life. Because few studies examine differences in the clinical management between the geriatric and general adult population, therapies should be based on current guidelines. Special considerations should be made when treating these patients in regards to multiple comorbidities and the potential for drug interactions from polypharmacy. Read More

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http://dx.doi.org/10.1016/j.otc.2018.03.008DOI Listing
August 2018
4 Reads

Deconstructing Pneumococcal Progression from Colonization to Disease.

Authors:
Stephen I Pelton

Infect Immun 2018 06 22;86(6). Epub 2018 May 22.

Boston University Schools of Medicine and Public Health and Division of Pediatric Infectious Diseases, Boston Medical Center, Boston, Massachusetts, USA

Despite advances in treatment and prevention, the pneumococcus continues to be a dominant cause of severe pneumonia and sepsis and of otitis media, sinusitis, and nonbacteremic pneumonia. Lewnard and colleagues (Infect Immun 86:e00727-17, 2018, https://doi.org/10. Read More

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http://iai.asm.org/lookup/doi/10.1128/IAI.00225-18
Publisher Site
http://dx.doi.org/10.1128/IAI.00225-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964524PMC
June 2018
14 Reads

Diagnosis and management of pediatric sinusitis: A survey of primary care, otolaryngology and urgent care providers.

Int J Pediatr Otorhinolaryngol 2018 May 27;108:163-167. Epub 2018 Feb 27.

Children's Hospital of Wisconsin / Medical College of Wisconsin - Milwaukee, 8915 W. Cornell Ct., Milwaukee, WI 53226, United States. Electronic address:

Objectives: The aims of this project were two-fold: 1) To assess pediatric primary care (PCP), pediatric otolaryngology (ENT) and pediatric urgent care (UC) providers' perception of their adherence to the 2013 American Academy of Pediatrics (AAP) established guidelines for the diagnosis and management of acute bacterial rhinosinusitis (ABRS) in children 1-18 years old and 2) to assess the same providers' practice patterns in the diagnosis and management of pediatric chronic rhinosinusitis (PCRS).

Method: A 21-item questionnaire (CVI .9) was designed by th investigators using Survey Monkey. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01655876183011
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http://dx.doi.org/10.1016/j.ijporl.2018.02.039DOI Listing
May 2018
8 Reads