4,792 results match your criteria Sinusitis Acute


A Periorbital Abscess with Combined Retinal Artery Occlusion and Retinal Vein Occlusion: A Case Report.

Am J Case Rep 2021 May 12;22:e930808. Epub 2021 May 12.

Head and Neck Unit, Department of Surgery, Clinical Hospital, Federal University of Goiás (HC-UFG), Goiânia, GO, Brazil.

BACKGROUND Periorbital abscesses are uncommon complications of acute bacterial rhinosinusitis; with the evolution of diagnostic and therapeutic methods, it is rare that the patient progresses to irreversible blindness. Central retinal artery occlusion (CRAO) and central retinal vein occlusion (CRVO) rarely occur simultaneously and the factors that influence this occurrence are not well understood. CASE REPORT This is a case report of an immunocompetent healthy adolescent girl, who developed irreversible blindness caused by a periorbital abscess secondary to acute bacterial rhinosinusitis due to CRAO and CRVO. Read More

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Central Retinal Artery Occlusion Due to Subperiosteal Orbital Abscess Caused by Acute Sinusitis in a Child: A Case Report.

Ear Nose Throat J 2021 May 12:1455613211016731. Epub 2021 May 12.

Department of Otolaryngology Head and Neck Surgery, 117747Qingdao University Medical College Affiliated Yantai Yuhuangding Hospital, Yantai, Shandong Province, China.

Central retinal artery occlusion (CRAO) is an ophthalmic emergency and has poor visual prognosis. It is commonly found in elderly people and very rare in child. We reported an 8-year-old girl who suffered from acute sinusitis, periorbital swelling, and the visual acuity of her right eye was only light perception. Read More

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Safety of a New Sinus Irrigation Device in Rhinosinusitis: A Pilot Study.

Ear Nose Throat J 2021 May 12:1455613211015417. Epub 2021 May 12.

26736Hillel Yaffe Medical Center, Hadera, Israel, Technion Faculty of Medicine, Haifa, Israel.

Background: Puncture and lavage of the paranasal sinuses, previously the primary treatment for unresponsive acute bacterial rhinosinusitis before surgery, has been abandoned due to procedural discomfort and advancements in antibiotic efficacy and endoscopic surgery. The rise in antibiotic-resistant bacteria has renewed the interest in minimally invasive sinus lavage to both avoid aggressive surgical interventions and identify appropriate antibiotic therapy. In this article, we describe the safety and feasibility of a new device in human patients and evaluate its efficacy as a treatment before the traditional sinus surgery in acute rhinosinusitis. Read More

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E-Cigarette Burns and Explosions: What are the Patterns of Oromaxillofacial Injury?

J Oral Maxillofac Surg 2021 Mar 29. Epub 2021 Mar 29.

William Beaumont Hospital - Royal Oak, Department of Otolaryngology, Royal Oak, MI.

Purpose: With the recent increase in popularity of electronic cigarette use in the United States, its harmful effects are not only limited to smoke inhalation, but also to the possibility of e-cigarette device malfunction. The purpose of this review is to characterize oromaxillofacial trauma secondary to electronic cigarette device explosion.

Methods: For this systematic review, PubMed and Embase were searched in October 2019 using the following search terms: e-cigarette burns, e-cigarette injury, and e-cigarette explosions, which yielded 400 studies. Read More

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Effects of large volume, isotonic nasal saline irrigation for acute rhinosinusitis: a randomized controlled study.

Int Forum Allergy Rhinol 2021 May 7. Epub 2021 May 7.

Department of Otolaryngology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Background: The purpose of this study was to compare the effects of nasal saline irrigation (large volume, positive pressure isotonic saline) in addition to standard treatment in patients with acute rhinosinusitis (ARS).

Methods: This parallel, randomized controlled trial was conducted at a tertiary hospital. The adult patients with ARS (age ≥18 years) were randomly assigned to two groups. Read More

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Detecting serum galactomannan to diagnose acute invasive Aspergillus sinusitis: a meta-analysis.

Eur Arch Otorhinolaryngol 2021 May 6. Epub 2021 May 6.

Department of Otorhinolaryngology, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemoon-gu, Seoul, 03722, Korea.

Purpose: The serum galactomannan test has been used for diagnosing acute invasive fungal sinusitis (AIFS), especially invasive Aspergillus. We aimed to assess the accuracy of the test to diagnose acute invasive Aspergillus sinusitis (AIAS).

Methods: We searched all relevant articles published in PubMed, Embase, the Cochrane Library, and Web of Science databases up until September 14, 2020. Read More

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Microbiology of Acute Maxillary Sinusitis in Children.

Laryngoscope 2021 May 3. Epub 2021 May 3.

Department of Otolaryngology, Matsubara ENT Clinic, Gifu, Japan.

Objectives/hypothesis: Acute rhinosinusitis is a frequent common cold-related complication in children. Despite the need for appropriate treatment, its underlying microbiology remains unclear. This study aimed to investigate the microbiology of acute rhinosinusitis in children. Read More

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Overcoming bacteriophage insensitivity in Staphylococcus aureus using clindamycin and azithromycinat sub-inhibitory concentrations.

Allergy 2021 Apr 30. Epub 2021 Apr 30.

Department of Surgery-Otolaryngology Head and Neck Surgery, Basil Hetzel Institute for Translational Health Research, Central Adelaide Local Health Network, Woodville South, Australia.

Staphylococcus aureus is a pathogen of major concern in both acute infections as well as chronic conditions such as chronic rhinosinusitis (CRS). Bacteriophage (phage) therapy has been considered in Western countries as early as the 1920s and has recently regained interest for its potential to treat infections caused by antibiotic resistant strains including Methicillin Resistant Staphylococcus aureus (MRSA). However, bacteria can adapt and become resistant to phages. Read More

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Exploratory research on asthma exacerbation risk factors using the Japanese claims database and machine learning: A retrospective cohort study.

J Asthma 2021 Apr 29:1-19. Epub 2021 Apr 29.

Faculty of Pharmaceutical Sciences, Teikyo Heisei University, Tokyo, Japan.

Objective: Analytical studies of risk factor assessment using machine learning have recently been reported. We performed an exploratory detection study of asthma exacerbation-related factors using health insurance claims data and machine learning to explore risk factors that have high generalizability and can be easily obtained in daily practice.

Methods: A dataset of asthma patients during May 2014-April 2019 from Japanese health insurance claims database, MediScope® (DB) was used. Read More

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Prevalence of and Factors Associated with Antibiotic Prescriptions in Patients with Acute Lower and Upper Respiratory Tract Infections-A Case-Control Study.

Antibiotics (Basel) 2021 Apr 16;10(4). Epub 2021 Apr 16.

Epidemiology, IQVIA Germany, 60549 Frankfurt am Main, Germany.

Background: The goal of the present study was to estimate the prevalence of patient and physician related variables associated with antibiotic prescriptions in patients diagnosed with acute lower and upper respiratory tract infections (ALURTI), treated in general practices (GP) and pediatric practices, in Germany.

Methods: The analysis included 1,140,095 adult individuals in 1237 general practices and 309,059 children and adolescents in 236 pediatric practices, from the Disease Analyzer database (IQVIA), who had received at least one diagnosis of an ALURTI between 1 January 2015 and 31 March 2019. We estimated the association between 35 predefined variables and antibiotic prescription using multivariate logistic regression models, separately for general and pediatric practices. Read More

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(Burm. f.) Wall. ex Nees: An Updated Review of Phytochemistry, Antimicrobial Pharmacology, and Clinical Safety and Efficacy.

Life (Basel) 2021 Apr 16;11(4). Epub 2021 Apr 16.

Department of Agricultural Sciences, University of Naples Federico II, 80055 Portici, Italy.

Infectious disease (ID) is one of the top-most serious threats to human health globally, further aggravated by antimicrobial resistance and lack of novel immunization options. (Burm. f. Read More

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A Herbal Formula in the Therapy of Acute Postviral Rhinosinusitis.

Turk Arch Otorhinolaryngol 2021 Mar 26;59(1):33-42. Epub 2021 Mar 26.

Institute of Pharmacy, Military Medical Academy Faculty of Medicine, University of Defence, Belgrade, Serbia.

Objective: To assess the effects and adverse events of preparation Sinulan forte containing extracts of five medicinal plants in comparison to mometasone furoate nasal spray (MFNS) in therapy of acute postviral rhinosinusitis (APRS).

Methods: We included 46 APRS patients in this prospective investigation and randomized to two groups. The patients in group 1 (n=23) received MFNS 200 μg two times/day for ten days, and patients in group 2 (n=23) received Sinulan forte, tablets 225 mg per os, two times/day also for ten days. Read More

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Kartagener syndrome: A case report.

Can J Respir Ther 2021 21;57:44-48. Epub 2021 Apr 21.

Pediatric Intensive Care Unit, Children's Damascus University Hospital, Damascus, Syria.

Kartagener syndrome is a rare, autosomal recessive genetic disorder that causes defects in the action of ciliary movement, comprises of triad situs inversus, chronic sinusitis, and bronchiectasis. We present the case of a 3-year-old boy with repeated respiratory infections and pneumonic infections presenting with acute respiratory failure. He was diagnosed with Kartagener syndrome based on his clinical presentation and imaging features. Read More

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A scoping review of longitudinal airway microbiota studies.

Expert Rev Respir Med 2021 Apr 28. Epub 2021 Apr 28.

Department of Surgery, The University of Auckland, Auckland, New Zealand.

Introduction: The role of the microbiota in inflammatory airway diseases is unclear. Antimicrobial therapies have predominantly been guided by culture results. However, molecular sequencing has shown that the airway microbiota is much more complex and accurate modeling requires longitudinal analysis. Read More

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COVID-19 triggering mucormycosis in a susceptible patient: a new phenomenon in the developing world?

BMJ Case Rep 2021 Apr 27;14(4). Epub 2021 Apr 27.

General Medicine, Nitte University K S Hegde Medical Academy, Mangalore, Karnataka, India.

A middle-aged woman with diabetes presented with left-sided facial pain, complete ptosis and fever of short duration. On presentation, she had hyperglycaemia without ketosis. There was total ophthalmoplegia of the left eye with a visual acuity of 6/36. Read More

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Clinical utility of antifungal susceptibility testing in patients with fungal rhinosinusitis.

Indian J Med Microbiol 2021 Apr 24. Epub 2021 Apr 24.

Department of ENT, Christian Medical College, Vellore, 632004, India. Electronic address:

Purpose: To determine the association between antifungal susceptibility test (AFST) results and in vivo therapeutic response in Indian patients with fungal rhinosinusitis.

Methods: The clinicoradiological, fungal culture, AFST, histopathology results and outcomes of 48 patients with fungal rhinosinusitis seen between 20132015 were analysed. Minimum inhibitory concentration (MIC) determination was performed for amphotericin B, itraconazole, voriconazole and posaconazole. Read More

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Prevalence of Common Disease Conditions in a Large Cohort of Individuals With Down Syndrome in the United States.

J Patient Cent Res Rev 2021 19;8(2):86-97. Epub 2021 Apr 19.

Department of Medicine, University of Chicago, Chicago, IL.

Purpose: Given the current life expectancy and number of individuals living with Down syndrome (DS), it is important to learn common occurrences of disease conditions across the developmental lifespan. This study analyzed data from a large cohort of individuals with DS in an effort to better understand these disease conditions, inform future screening practices, tailor medical care guidelines, and improve utilization of health care resources.

Methods: This retrospective, descriptive study incorporated up to 28 years of data, compiled from 6078 individuals with DS and 30,326 controls matched on age and sex. Read More

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Case Report: Cerebrovascular Events Associated With Bacterial and SARS-CoV-2 Infections in an Adolescent.

Front Neurol 2021 8;12:606617. Epub 2021 Apr 8.

French Center for Pediatric Stroke, Pediatric Neurology Department, APHP University Hospital Necker-Enfants Malades, Paris, France.

Neurologic manifestations associated with Covid-19 are increasingly reported, especially stroke and acute cerebrovascular events. Beyond cardiovascular risk factors associated with age, some young adults without medical or cardiovascular history had stroke as a presenting feature of Covid-19. Suggested stroke mechanisms in this setting are inflammatory storm, subsequent hypercoagulability, and vasculitis. Read More

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Mechanical compression enhances ciliary beating through cytoskeleton remodeling in human nasal epithelial cells.

Acta Biomater 2021 Apr 18. Epub 2021 Apr 18.

School of Mechanical Engineering, Yonsei University, Seoul, Korea. Electronic address:

Nasal inflammatory diseases, including nasal polyps and acute/chronic sinusitis, are characterized by impaired mucociliary clearance and eventually inflammation and infection. Contact of nasal polyps with adjacent nasal mucosa or stagnated mucus within the maxillary sinus produces compressive mechanical stresses on the apical surface of epithelium which can induce cytoskeleton remodeling in epithelial cells. In this study, we hypothesized that compressive stress modulates ciliary beating by altering the mechanical properties of the cytoskeleton of ciliated cell basal bodies. Read More

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Annual trends in Google searches provides insights related to rhinosinusitis exacerbations.

Eur Arch Otorhinolaryngol 2021 Apr 20. Epub 2021 Apr 20.

Department of Otorhinolaryngology, Head and Neck Surgery, Vienna General Hospital (AKH), Medical University of Vienna, Vienna, Austria.

Purpose: Temporal trends of disease-specific internet searches may provide novel insights into seasonal dynamics of disease burden and, by extension, disease pathophysiology. The aim of this study was to define the temporal trends in rhinosinusitis-specific internet searches.

Methods: This was a cross sectional analysis of search volume for predefined search terms. Read More

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Effects of nasopharyngeal microbiota in respiratory infections and allergies.

Clin Exp Pediatr 2021 Apr 15. Epub 2021 Apr 15.

Division of Pediatric Infectious Diseases, Departments of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea.

The human microbiome, which consists of a collective cluster of commensal, symbiotic, and pathogenic microorganisms living in the human body, plays a key role in host health and immunity. The human nasal cavity harbors commensal bacteria that suppress the colonization of opportunistic pathogens. However, dysbiosis of the nasal microbial community is associated with many diseases, such as acute respiratory infections including otitis media, sinusitis and bronchitis and allergic respiratory diseases including asthma. Read More

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Association of US Food and Drug Administration Removal of Indications for Use of Oral Quinolones With Prescribing Trends.

JAMA Intern Med 2021 Apr 19. Epub 2021 Apr 19.

Department of Pharmaceutical Outcomes and Policy, College of Pharmacy, University of Florida, Gainesville.

Importance: In May 2016, due to concerns of the risks outweighing the benefits, the US Food and Drug Administration (FDA) removed systemic quinolones' indications for acute, uncomplicated urinary tract infection (uUTI), acute sinusitis (AS), and acute exacerbation of chronic obstructive pulmonary disease (AE-COPD). How the change influenced oral quinolone use is unknown.

Objective: To assess the association of oral quinolone safety warnings and indication restrictions with use. Read More

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Neuraminidase inhibitors and single dose baloxavir are effective and safe in uncomplicated influenza: a meta-analysis of randomized controlled trials.

Expert Rev Clin Pharmacol 2021 Apr 26:1-18. Epub 2021 Apr 26.

CIBER De Enfermedades Respiratorias (CIBERES), Instituto Salud Carlos III, Madrid, Spain.

: Scarce evidence verifying the clinical impact of baloxavir on influenza complications is found.: PubMed, Cochrane Library, and Web of Science databases were searched through December 2020. Randomized-controlled trials (RCT) that enrolled patients with laboratory-confirmed influenza receiving neuraminidase inhibitors (NAI) or baloxavir comparing to placebo were assessed. Read More

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Impact of Asynchronous Electronic Communication-Based Visits on Clinical Outcomes and Health Care Delivery: Systematic Review.

J Med Internet Res 2021 05 5;23(5):e27531. Epub 2021 May 5.

Department of Health Outcomes and Behavior, Moffitt Cancer Center, Tampa, FL, United States.

Background: Electronic visits (e-visits) involve asynchronous communication between clinicians and patients through a secure web-based platform, such as a patient portal, to elicit symptoms and determine a diagnosis and treatment plan. E-visits are now reimbursable through Medicare due to the COVID-19 pandemic. The state of evidence regarding e-visits, such as the impact on clinical outcomes and health care delivery, is unclear. Read More

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Impact of a Social Marketing Intervention on General Practitioners' Antibiotic Prescribing Practices for Acute Respiratory Tract Complaints in Malta.

Antibiotics (Basel) 2021 Mar 31;10(4). Epub 2021 Mar 31.

Department of Global Public Health, Health Systems and Policy: Improving Use of Medicines, Karolinska Institutet, 171 77 Stockholm, Sweden.

Antibiotics are commonly prescribed in primary care for acute respiratory tract complaints (aRTCs), often inappropriately. Social marketing interventions could improve prescribing in such settings. We evaluate the impact of a social marketing intervention on general practitioners' (GPs') antibiotic prescribing for aRTCs in Malta. Read More

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Perioperative Indicators of Prognosis in Acute Invasive Fungal Sinusitis.

OTO Open 2021 Jan-Mar;5(1):2473974X211002547. Epub 2021 Mar 11.

Department of Otolaryngology-Head and Neck Surgery, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.

Objective: The purpose of this study is to identify perioperative independent prognostic factors that are available to the consulting team to aid in determining prognosis in patients with acute invasive fungal sinusitis.

Study Design: Retrospective chart review of patients with biopsy-proven acute invasive fungal sinusitis from 2015 to 2018.

Setting: Academic tertiary care center. Read More

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Draft genome sequence of a nontypeable Haemophilus influenzae strain used in the study of human respiratory infection.

BMC Res Notes 2021 Apr 1;14(1):123. Epub 2021 Apr 1.

Department of Pharmacy and Biomedical Sciences, School of Molecular Sciences, College of Science, Health and Engineering, La Trobe University, Victoria, 3690, Australia.

Objectives: Nontypeable Haemophilus influenzae (NTHi) is an important human respiratory bacterium that can cause a range of diseases including sinusitis, otitis media, conjunctivitis, pneumonia as well as acute exacerbations of chronic obstructive pulmonary disease (COPD). A number of studies have used NTHi clinical isolate RHH-3 as a laboratory strain for experimentation examining the effect of cigarette smoke and more recently, biomass smoke, on the susceptibility and response of cells lining the respiratory tract to infection. Therefore, definition of the genome content of RHH-3 is required to fully elucidate human-NTHi interactions associated with initial infection and subsequent development of respiratory disease. Read More

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Syringe with Nasal Applicator versus Syringe Alone for Nasal Irrigation in Acute Rhinosinusitis: A Matched-Pair Randomized Controlled Trial.

Biomed Hub 2021 Jan-Apr;6(1):25-29. Epub 2021 Jan 27.

Department of Otorhinolaryngology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.

Background/aims: Nasal saline irrigation is a common procedure to relieve nasal symptoms in upper respiratory tract diseases. There is no consensus on the recommended nasal saline delivery devices. The objectives of this study were to evaluate efficacy, satisfaction, adherence, and adverse effects in patients with acute upper respiratory tract diseases using a syringe with a nasal applicator for nasal irrigation. Read More

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January 2021

Trigeminal Neuralgia from Acute Sphenoid Sinusitis: Consideration of Anatomical Sphenoid Sinus Variation - A Case Report.

Case Rep Neurol 2021 Jan-Apr;13(1):171-178. Epub 2021 Mar 10.

Department of Otolaryngology, Aoyama General Hospital, Toyokawa, Japan.

Although the etiology of classical trigeminal neuralgia is clearly understood to be neurovascular compression, the exact etiology of trigeminal neuralgia with continuous pain is often unknown. Mild sphenoid sinusitis is not usually considered to induce trigeminal neuralgia, especially when limited to the maxillary nerve. We report a rare case of trigeminal neuralgia of the maxillary nerve caused only by mild sphenoid sinusitis and discuss the significance of the anatomical structure and diagnostic procedures. Read More

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Murine Model of Sinusitis Infection for Screening Antimicrobial and Immunomodulatory Therapies.

Front Cell Infect Microbiol 2021 12;11:621081. Epub 2021 Mar 12.

Centre for Microbial Diseases and Immunity Research, University of British Columbia, Vancouver, BC, Canada.

The very common condition of sinusitis is characterized by persistent inflammation of the nasal cavity, which contributes to chronic rhinosinusitis and morbidity of cystic fibrosis patients. Colonization by opportunistic pathogens such as and triggers inflammation that is exacerbated by defects in the innate immune response. Pathophysiological mechanisms underlying initial colonization of the sinuses are not well established. Read More

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