4,598 results match your criteria Sinusitis Acute


Embedded Research in the Learning Healthcare System: Ongoing Challenges and Recommendations for Researchers, Clinicians, and Health System Leaders.

J Gen Intern Med 2020 May 29. Epub 2020 May 29.

Kaiser Permanente Bernard J. Tyson School of Medicine, Pasadena, CA, USA.

Embedded research is an innovative means to improve performance in the learning healthcare system (LHS). However, few descriptions of successful embedded research programs have been published. In this perspective, we describe the Care Improvement Research Team, a mature partnership between researchers and clinicians at Kaiser Permanente Southern California. Read More

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http://dx.doi.org/10.1007/s11606-020-05865-4DOI Listing

Intramuscular Corticosteroids for Acute Upper Respiratory Infections Affects Healthcare Utilization.

Ann Otol Rhinol Laryngol 2020 May 26:3489420929717. Epub 2020 May 26.

Tulane University School of Medicine, Department of Otolaryngology-Head and Neck Surgery, New Orleans, LA, USA.

Objective: To examine the use of intramuscular corticosteroid (IMCS) injections for treatment of acute upper respiratory infections (URI) and the influence on healthcare utilization.

Methods: This retrospective cohort study used patient encounter data from a large multicenter regional health care system between 2013 and 2017. Adult patients diagnosed with acute URI (acute pharyngitis, acute sinusitis, acute otitis media, and URI not otherwise specified) during ambulatory encounters were included. Read More

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http://dx.doi.org/10.1177/0003489420929717DOI Listing

Herbal Drug EPs 7630 Amoxicillin in Patients with Uncomplicated Acute Bacterial Rhinosinusitis: A Randomized, Open-Label Study.

Ann Otol Rhinol Laryngol 2020 May 26:3489420918266. Epub 2020 May 26.

Institute for Pharmacy, Military Medical Academy Faculty of Medicine, University of Defence, Belgrade, Serbia.

Objective: Previous investigations suggest the use of extract from the root of (EPs 7630) for the therapy of uncomplicated acute upper airway inflammations, due to its strong antimicrobial and immunomodulatory effect. We aimed to compare clinical efficacy, safety and bactericidal effect of EPs 7630 and amoxicillin monotherapy in treatment of patients with mild to moderate acute bacterial rhinosinusitis (ABRS).

Methods: Fifty ABRS patients were divided into two groups by randomization. Read More

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http://dx.doi.org/10.1177/0003489420918266DOI Listing

The Impact of the Pandemic on Otolaryngology Patients With Negative COVID-19 Status: Commentary and Insights From Orbital Emergencies.

Otolaryngol Head Neck Surg 2020 May 26:194599820931082. Epub 2020 May 26.

Department of Ophthalmology, Northwell Health, Great Neck, New York, USA.

Efforts aimed at minimizing the spread of COVID-19 and "flattening the curve" may be affecting clinical care delivery for non-COVID-19 cases that include otolaryngologic and orbital conditions. We are witnessing changes in the manner that patients present, as well as modifications in clinical management strategies. An improved understanding of these phenomena and the contributing factors is essential for otolaryngologists to provide sound clinical care during this unprecedented pandemic. Read More

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http://dx.doi.org/10.1177/0194599820931082DOI Listing

Infectious Disease and Primary Care Research-What English General Practitioners Say They Need.

Antibiotics (Basel) 2020 May 20;9(5). Epub 2020 May 20.

Primary Care and Interventions Unit, Public Health England, Gloucester GL1 1DQ, UK.

Background: Infections are one of the most common reasons for patients attending primary care. Antimicrobial resistance (AMR) is perhaps one of the biggest threats to modern medicine; data show that 81% of antibiotics in the UK are prescribed in primary care.

Aim: To identify where the perceived gaps in knowledge, skills, guidance and research around infections and antibiotic use lie from the general practitioner (GP) viewpoint. Read More

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http://dx.doi.org/10.3390/antibiotics9050265DOI Listing

Incidence and extent of sinus procedures in treatment of pediatric orbital cellulitis.

Int J Pediatr Otorhinolaryngol 2020 May 6;135:110086. Epub 2020 May 6.

Department of Otolaryngology, University of Kansas Medical Center, Kansas City, KS, USA.

Introduction: It is unknown the optimal extent of sinus surgery in pediatric patients with orbital cellulitis. Our aim was to determine the nationwide incidence of sinus procedures used to treat pediatric orbital cellulitis. Additionally, we sought to identify patient-factors that influence a multi-procedural approach. Read More

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http://dx.doi.org/10.1016/j.ijporl.2020.110086DOI Listing

Orbital complications of acute bacterial rhinosinusitis in the pediatric population: A systematic review and meta-analysis.

Int J Pediatr Otorhinolaryngol 2020 May 6;135:110078. Epub 2020 May 6.

Department of Otolaryngology - Head and Neck Surgery, Medical University of South Carolina, Charleston, SC, USA.

Objectives: Assess characteristics and outcomes of orbital complications of acute bacterial rhinosinusitis (ABRS) in the pediatric population and evaluate trends over time.

Methods: A literature search of pediatric orbital complications was performed in the following databases: Ovid MEDLINE, Scopus, and Cochrane Database of Systematic Reviews. Studies reporting data for at least 10 subjects with orbital complications of sinusitis under 18 years old were included. Read More

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http://dx.doi.org/10.1016/j.ijporl.2020.110078DOI Listing

Combined in-person and tele-delivered mobile school clinic: A novel approach for improving access to healthcare during school hours.

J Telemed Telecare 2020 May 11:1357633X20917497. Epub 2020 May 11.

Department of Pediatrics, Erlanger Medical Center, USA.

Aims: We report a novel pilot project that allows access to healthcare for children and staff at school via a mobile clinic or telemedicine portal connected to the mobile clinic. The objectives of this pilot project were (a) to perform physicals for children not attached to a primary care physician; (b) to provide medical consultations and treatment for acute illnesses of students and staff, and (c) to lower absenteeism rates among students and staff.

Methods: In 2013, Ronald McDonald House Charities, a non-profit organization, partnered with Children's Hospital of Erlanger to provide a mobile clinic trademarked Ronald McDonald Care Mobile utilising a large, box-style truck equipped with examination rooms and a telemedicine portal. Read More

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http://dx.doi.org/10.1177/1357633X20917497DOI Listing

Outpatient fluoroquinolone prescribing patterns before and after US FDA boxed warning.

Pharmacoepidemiol Drug Saf 2020 May 11. Epub 2020 May 11.

Department of Internal Medicine, Baylor College of Medicine, Houston, Texas, USA.

Objectives: Fluoroquinolones are routinely overprescribed for uncomplicated urinary tract infection (uUTI), acute sinusitis, and acute bronchitis. In 2016, the United States (US) Food and Drug Administration (FDA) updated the boxed warning on fluoroquinolones, recommending against their use as first-line agents for the routine pharmacologic management of uUTI, acute sinusitis, and acute bronchitis in patients who have other treatment options. The primary objective of this study was to determine if the 2016 expanded boxed warning was associated with decreased fluoroquinolone prescription rates for these three diagnoses. Read More

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http://dx.doi.org/10.1002/pds.5018DOI Listing

The potential negative impact of antibiotic pack on antibiotic stewardship in primary care in Switzerland: a modelling study.

Antimicrob Resist Infect Control 2020 May 8;9(1):60. Epub 2020 May 8.

Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, Petersgraben 4, 4031, Basel, Switzerland.

Background: In Switzerland, oral antibiotics are dispensed in packs rather than by exact pill-count. We investigated whether available packs support compliance with recommended primary care treatment regimens for common infections in children and adults.

Methods: Hospital-based guidelines for oral community -based treatment of acute otitis media, sinusitis, tonsillopharyngitis, community-acquired pneumonia and afebrile urinary tract infection were identified in 2017 in an iterative process by contacting hospital pharmacists and infectious diseases specialists. Read More

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http://dx.doi.org/10.1186/s13756-020-00724-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7206713PMC

Unnecessary antibiotic prescribing in a Canadian primary care setting: a descriptive analysis using routinely collected electronic medical record data.

CMAJ Open 2020 Apr-Jun;8(2):E360-E369. Epub 2020 May 7.

Public Health Ontario (Schwartz, Langford, Brown, Johnstone, Leung, Wu, Garber); ICES Central (Schwartz, Daneman, Chen, Brown, Candido); Unity Health Network (Langford), St. Joseph Health Centre; Sunnybrook Research Institute (Daneman); Ray D. Wolfe Department of Family Medicine (McIsaac), Sinai Health System; Departments of Family & Community Medicine (McIsaac, Tu) and Laboratory Medicine and Pathobiology (Johnstone), University of Toronto; North York General Hospital (Tu); Toronto Western Hospital Family Health Team (Tu), University Health Network; Toronto East Health Network (Leung), Michael Garron Hospital; Dalla Lana School of Public Health (Hwee), University of Toronto, Toronto, Ont.; Institute for Better Health (Hwee), Trillium Health Partners, Mississauga, Ont.; London Health Sciences Centre (Silverman), London, Ont.; Ottawa Hospital Research Institute (Garber); Department of Medicine (Garber), University of Ottawa, Ottawa, Ont.

Background: Unnecessary antibiotic use in the community in Canada is not well defined. Our objective was to quantify unnecessary antibiotic prescribing in a Canadian primary care setting.

Methods: We performed a descriptive analysis in Ontario from April 2011 to March 2016 using the Electronic Medical Records Primary Care database linked to other health administrative data sets at ICES. Read More

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http://dx.doi.org/10.9778/cmajo.20190175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7207032PMC

FDA collaboration to improve safe use of fluoroquinolone antibiotics: an matched control study of targeted short-form messaging and online education served to high prescribers.

Pharm Pract (Granada) 2020 Apr-Jun;18(2):1773. Epub 2020 Apr 24.

MBA. Group Vice President. Marketing Sciences, WebMD. New York, NY (United States).

Objective: This matched control study was conducted to evaluate the effect of targeted short-form messages or continuing medical education (CME) on fluoroquinolone prescribing among high prescribers.

Methods: A total of 11,774 Medscape healthcare provider (HCP) members prescribing high volumes of fluoroquinolones were randomized into three segments to receive one of three unique targeted short-form messages, each delivered via email, web alerts, and mobile alerts. Some HCPs receiving targeted short-form messages also participated in CME on fluoroquinolone prescribing. Read More

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http://dx.doi.org/10.18549/PharmPract.2020.2.1773DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7194042PMC

Incidence of pharyngitis, sinusitis, acute otitis media, and outpatient antibiotic prescribing preventable by vaccination against group A Streptococcus in the United States.

Clin Infect Dis 2020 May 6. Epub 2020 May 6.

Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.

Background: Group A Streptococcus (GAS) is a leading cause of acute respiratory infections frequently resulting in antibiotic prescribing. Vaccines against GAS are currently in development.

Methods: We estimated the incidence of healthcare visits and antibiotic prescribing for pharyngitis, sinusitis, and acute otitis media (AOM) in the United States using nationally-representative surveys of outpatient care provision, supplemented by insurance claims data. Read More

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http://dx.doi.org/10.1093/cid/ciaa529DOI Listing

A computerized decision support system (CDSS) for antibiotic prescription in primary care-Antibioclic: implementation, adoption and sustainable use in the era of extended antimicrobial resistance.

J Antimicrob Chemother 2020 May 1. Epub 2020 May 1.

Antibioclic steering committee, Paris, France.

Objectives: To describe the implementation and use of a computerized decision support system (CDSS) for antibiotic prescription in primary care in France (Antibioclic). The CDSS targets 37 infectious diseases and has been freely available on a website since 2011.

Methods: Description and implementation of the architecture of a CDSS for antibiotic prescription in general practice. Read More

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http://dx.doi.org/10.1093/jac/dkaa167DOI Listing

Mycoplasma Pneumoniae Induced Rash and Mucositis with Bilateral Otitis Media and Sinusitis.

Cureus 2020 Mar 28;12(3):e7449. Epub 2020 Mar 28.

Otolaryngology, McLaren Oakland Hospital, Pontiac, USA.

Mycoplasma pneumoniae induced rash and mucositis (MIRM) is a recently identified clinical entity, which describes a subset of extrapulmonary manifestations resulting from Mycoplasma pneumonia infection. Patients present with a wide variety of symptoms including cough, dyspnea, mucositis, conjunctivitis, with or without a variable cutaneous rash. A 24-year-old male presented to the emergency department with worsening dyspnea and new-onset oral, ocular, and genital mucosal lesions. Read More

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http://dx.doi.org/10.7759/cureus.7449DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186110PMC

Early experience with feasibility of balloon sinus dilation in complicated pediatric acute frontal rhinosinusitis.

Laryngoscope Investig Otolaryngol 2020 Apr 14;5(2):194-199. Epub 2020 Feb 14.

Department of Otolaryngology-Head and Neck Surgery Weill Cornell Medical College New York New York.

Background/objective: Complicated acute rhinosinusitis in the pediatric population is an uncommon problem that may affect the orbit or brain and is life-threatening. This condition requires surgical intervention with endoscopic sinus surgery for source control, and prior studies have demonstrated the safety of balloon sinuplasty in chronic frontal sinusitis.

Methods/results: We present our approach with a balloon sinus dilation hybrid procedure to resolve four distinct types of complicated acute frontal sinusitis in pediatric patients, including intracranial manifestations, intraorbital complications, and recurrent disease. Read More

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http://dx.doi.org/10.1002/lio2.359DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178448PMC

An educational intervention to promote appropriate antibiotic use for acute respiratory infections in a district in Egypt- pilot study.

BMC Public Health 2019 May 10;19(Suppl 3):498. Epub 2019 May 10.

Global Disease Detection Center, US CDC, Cairo, Egypt.

Background: Antibiotic overuse is the most important modifiable factor contributing to antibiotic resistance. We conducted an educational campaign in Minya, Egypt targeting prescribers and the public through communications focused on appropriate antibiotic use for acute respiratory infections (ARIs).

Methods: The entire population of Minya was targeted by the campaign. Read More

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http://dx.doi.org/10.1186/s12889-019-6779-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6696705PMC

Reducing Antibiotic Use in Ambulatory Care through Influenza Vaccination.

Clin Infect Dis 2020 Apr 23. Epub 2020 Apr 23.

Centers for Disease Control and Prevention, Atlanta, Georgia, USA.

Background: Improving appropriate antibiotic use is crucial for combating antibiotic resistance and unnecessary adverse drug reactions. Acute respiratory illness (ARI) commonly causes outpatient visits and accounts for ~41% of antibiotics used in the United States (U.S. Read More

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http://dx.doi.org/10.1093/cid/ciaa464DOI Listing
April 2020
8.886 Impact Factor

Impact of a Multifaceted Antimicrobial Stewardship Intervention in a Primary Health Care Area: A Quasi-Experimental Study.

Front Pharmacol 2020 2;11:398. Epub 2020 Apr 2.

Medicine Department, Universitat Internacional de Catalunya, Barcelona, Spain.

The aim of the study was to evaluate the impact of a multifaceted antimicrobial stewardship intervention on antibiotic consumption in a primary health care (PHC) area in Spain. Quasi-experimental study conducted in a PHC area with nine PHC centers, a 400-bed acute care teaching hospital, and 18 nursing homes serving a population of 260,561. The intervention was based on the 2016 CDC Core Elements of Outpatient Antibiotic Stewardship publication and targeted 130 PHC physicians, 41 PHC pediatricians, 19 emergency physicians, and 18 nursing home physicians. Read More

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http://dx.doi.org/10.3389/fphar.2020.00398DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7142248PMC

[Acute infectious disease of otolaryngology focus].

Medicine (Madr) 2019 Nov 11;12(91):5339-5351. Epub 2019 Dec 11.

Servicio de Otorrinolaringología, Hospital Universitario Príncipe de Asturias, Alcalá de Henares, Madrid, España.

Infections are the most common cause of antibiotic prescription and one of the most frequent reasons for consultation in Primary Care. Among them, stand out acute media otitis and diffuse external otitis, acute pharyngitis and acute rhinosinusitis. Commonly they are viral and self-limited, so their complications are rare. Read More

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http://dx.doi.org/10.1016/j.med.2019.11.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7143590PMC
November 2019

"Very High-Grade" Pulsatile Mass of an Aberrant Internal Carotid Artery in the Nasopharyngeal Wall: A Case Report and Review of Literature.

Am J Case Rep 2020 Apr 13;21:e921967. Epub 2020 Apr 13.

Department of Radiology, Vinmec Healthcare System, Nha Trang City, Vietnam.

BACKGROUND The prevalence of aberrant internal carotid artery (ICA) is extremely low in the general population. It commonly occurs in the neck. Close proximity of the pulsatile submucosal mass of the aberrant ICA to the nasopharyngeal wall is dangerous. Read More

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http://dx.doi.org/10.12659/AJCR.921967DOI Listing

Complications of sinusitis: An 80-case series from the ENT and neurosurgery departments of the Fann university hospital center of Dakar, Senegal.

Eur Ann Otorhinolaryngol Head Neck Dis 2020 Apr 9. Epub 2020 Apr 9.

Université de Thies, Thies, Senegal.

Introduction: Locoregional complications of sinusitis are dominated by oculo-orbital and/or cranioencephalic manifestations that may be life-threatening or jeopardize functional prognosis. The aim of this study was to report epidemiological, diagnostic and therapeutic aspects.

Materials And Methods: A retrospective study included inpatients managed for sinusitis complications in the ENT and neurosurgery departments of the Fann university hospital center in Dakar, Senegal between January 1, 2005 and December 31, 2016. Read More

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http://dx.doi.org/10.1016/j.anorl.2020.03.014DOI Listing

Application of a simple point-of-care test to reduce UK healthcare costs and adverse events in outpatient acute respiratory infections.

J Med Econ 2020 Apr 7:1-10. Epub 2020 Apr 7.

FIND (Foundation for Innovative New Diagnostic), Geneva, Switzerland.

Acute respiratory infection (ARI) accounts for over two-thirds of total antibiotic prescriptions although most are caused by viruses that do not benefit from antibiotics. Most antibiotics are prescribed in the outpatients setting. Antibiotic overuse leads to antibiotic-related adverse events (AEs), inclusive of secondary infections, resistance, and increased costs. Read More

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http://dx.doi.org/10.1080/13696998.2020.1736872DOI Listing

Thermography for the Diagnosis of Acute Inflammation in the Paranasal Sinus.

Int Arch Otorhinolaryngol 2020 Apr 28;24(2):e215-e220. Epub 2020 Jan 28.

Department of Otorhinolaryngology, Hyotan-machi ENT Clinic, Kanazawa, Ishikawa, Japan.

 Although computed tomography scanning is the most common method for the diagnosis of sinusitis today, X-ray imaging is still used in outpatient clinics. Because X-ray imaging is beneficial for patients with severe sinusitis but not for those with mild sinusitis, an alternative method to visualize sinusitis without X-ray imaging is desirable.  To study the possibility of using thermography to visualize sinusitis. Read More

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http://dx.doi.org/10.1055/s-0039-1698778DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6986953PMC

A rare cause of acute abdominal pain in a patient with Primary ciliary dyskinesia with situs inversus totalis.

Turk J Pediatr 2020 ;62(1):156-159

Departments of Pediatric Pulmonology, Hacettepe University Faculty of Medicine, Ankara, Turkey.

Primary ciliary dyskinesia (PCD) is a rare, genetic disease characterized by ciliary dysfunction. Patients may present with respiratory distress during neonatal period; chronic sinopulmonary disease, bronchiectasis, recurrent otitis media, sinusitis and infertility in later periods. About 50% of PCD patients have situs inversus totalis and 6-12% have situs ambiguous known as heterotaxy syndromes. Read More

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http://dx.doi.org/10.24953/turkjped.2020.01.024DOI Listing
January 2020

[Discussion on safety of Xanthii Fructus and consideration on its rational use].

Zhongguo Zhong Yao Za Zhi 2019 Dec;44(24):5336-5344

Beijing University of Chinese Medicine Beijing 100029,China.

Xanthii Fructus is a traditional Chinese medicine for the treatment of sinusitis and headache,rich in medicinal materials and is widely used for more than 1 800 years. Modern pharmacological studies have showed that Xanthii Fructus has anti-inflammatory,analgesic,anti-tumor,anti-bacterial,hypoglycemic,anti-allergic,immunomodulatory and other pharmacological effects,which can be commonly used in the treatment of diseases relating to immune abnormalities,such as rheumatoid arthritis,acute and chronic rhinitis,allergic rhinitis,and skin diseases,with a high medicinal value. Toxicological studies have shown that Xanthii Fructus poisoning can cause substantial damage to organs,such as the liver,kidney,and gastrointestinal tract,especially to liver. Read More

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http://dx.doi.org/10.19540/j.cnki.cjcmm.20190701.403DOI Listing
December 2019

Prescribing systemic steroids for acute respiratory tract infections in United States outpatient settings: A nationwide population-based cohort study.

PLoS Med 2020 Mar 31;17(3):e1003058. Epub 2020 Mar 31.

Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America.

Background: Evidence and guidelines do not support use of systemic steroids for acute respiratory tract infections (ARTIs), but such practice appears common. We aim to quantify such use and determine its predictors.

Methods And Findings: We conducted a cohort study based on a large United States national commercial claims database, the IBM MarketScan, to identify patients aged 18-64 years with an ARTI diagnosis (acute bronchitis, sinusitis, pharyngitis, otitis media, allergic rhinitis, influenza, pneumonia, and unspecified upper respiratory infections) recorded in ambulatory visits from 2007 to 2016. Read More

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http://dx.doi.org/10.1371/journal.pmed.1003058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7108689PMC

[MORAXELLA OSLOENSIS BACTEREMIA WITH PNEUMONIA: FIRST REPORTED CASE IN ISRAEL].

Harefuah 2020 Mar;159(3):163-165

Galilee Medical Center, Department of Internal Medicine "D", Nahariya.

Introduction: Community acquired pneumonia (CAP), an acute infection of the pulmonary parenchyma acquired in the community, is generally treated in an outpatient setting and involves different etiological agents. In the adult community, the most common pathogen in the disease is Streptococcus pneumonia, though other multiple etiological agents (atypical) have been involved, including Mycoplasma pneumoniae, Chlamydophila pneumoniae, and Legionella pneumophila. The genus Moraxella consists of aerobic, oxidase-positive gram-negative coccobacilli. Read More

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Acute Appendicitis in Patients with Kartagener Syndrome.

Case Rep Surg 2020 27;2020:8716474. Epub 2020 Feb 27.

Department of General Surgery, Santa Casa de São Carlos, SP, Brazil.

Situs inversus totalis is a congenital syndrome characterized by a total left-right transposition of all abdominal and thoracic organs. It may be associated with chronic respiratory conditions such as sinusitis and bronchiectasis, composing the Kartagener syndrome. If not detected, this condition may compromise the early diagnosis of surgical emergencies such as cholecystitis and appendicitis. Read More

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http://dx.doi.org/10.1155/2020/8716474DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063213PMC
February 2020

Indications and Outcomes for Patients With Limited Symptoms Undergoing Endoscopic Sinus Surgery.

Am J Rhinol Allergy 2020 Jul 13;34(4):502-507. Epub 2020 Mar 13.

Division of Rhinology, Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Palo Alto, California.

Background: Previous research have suggested that chronic rhinosinusitis (CRS) patients with lower symptomatic scores, demonstrated by a 22-item Sinonasal Outcome Test (SNOT-22) score <20, may not achieve meaningful quality of life improvement following endoscopic sinus surgery (ESS). However, indications for ESS are continuing to be defined and many low SNOT-22 scoring patients still undergo elective surgery for CRS and other benign sinonasal pathologies. The outcomes for these patients have not been previously studied. Read More

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http://dx.doi.org/10.1177/1945892420912159DOI Listing

Symmetric polyneuropathy after viral symptomatology - not always Guillain-Barré Syndrome.

Acta Clin Belg 2020 Mar 13:1-8. Epub 2020 Mar 13.

Department of Nephrology, AZ St. Elisabeth Hospital, Zottegem, Belgium.

: Guillain-Barré Syndrome usually presents with ascending symmetric polyneuropathy, typically preceded by a viral infection. Despite the low incidence, physicians will often include Guillain-Barré Syndrome in their differential diagnosis. However, another underlying cause of polyneuropathy known as ANCA-associated vasculitis (AAV) is even more rare than Guillain-Barré Syndrome and therefore is usually overlooked. Read More

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http://dx.doi.org/10.1080/17843286.2020.1740858DOI Listing

Low Uptake of Rapid Diagnostic Tests for Respiratory Tract Infections in an Urban Safety Net Hospital.

Open Forum Infect Dis 2020 Mar 3;7(3):ofaa057. Epub 2020 Mar 3.

Section of Infectious Diseases, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA.

Background: Rapid diagnostic tests (RDTs) have been developed with the aim of providing accurate results in a timely manner. Despite this, studies report that provider uptake remains low.

Methods: We conducted a retrospective analysis of ambulatory, urgent care, and emergency department (ED) encounters at an urban safety net hospital with a primary diagnosis of an upper or lower respiratory tract infection (eg, bronchitis, pharyngitis, acute sinusitis) from January 1, 2016, to December 31, 2018. Read More

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http://dx.doi.org/10.1093/ofid/ofaa057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7060900PMC

Multicenter evaluation of the QIAstat Respiratory Panel-A new rapid highly multiplexed PCR based assay for diagnosis of acute respiratory tract infections.

PLoS One 2020 12;15(3):e0230183. Epub 2020 Mar 12.

Department of Clinical Microbiology, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark.

Acute respiratory tract infections (ARTI), including the common cold, pharyngitis, sinusitis, otitis media, bronchiolitis and pneumonia are the most common diagnoses among patients seeking medical care in western countries, and account for most antibiotic prescriptions. While a confirmed and fast ARTI diagnosis is key for antibiotic prescribing, empiric antimicrobial treatment remains common, because viral symptoms are often clinically similar and difficult to distinguish from those caused by bacteria. As a result, inappropriate antibiotic prescriptions are high and in certain settings likely higher than the commonly estimated 30%. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0230183PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067435PMC

First Case of Invasive Stachybotrys Sinusitis.

Clin Infect Dis 2020 Mar 10. Epub 2020 Mar 10.

Department of Molecular Imaging and Therapy, Diabetes and Metabolism Research Institute, Beckman Research Institute, Duarte, California, USA.

Background: The toxigenic mold Stachybotrys has controversially been linked to idiopathic pulmonary hemorrhage and "sick building syndrome". However, there are no previous clinical records of invasive stachybotryosis.

Methods: Sinus biopsy specimens from a 23-year old male with refractory acute lymphocytic leukemia were obtained at three different time points during the patient's hospitalization (139 days) and examined by histopathology and immunohistochemistry (IHC). Read More

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http://dx.doi.org/10.1093/cid/ciaa231DOI Listing

Antibiotic use and serious complications following acute otitis media and acute sinusitis: a retrospective cohort study.

Br J Gen Pract 2020 Apr 26;70(693):e255-e263. Epub 2020 Mar 26.

School of Primary Care, Population Sciences and Medical Education, Aldermoor Health Centre, Southampton.

Background: Most people with acute otitis media (AOM) and acute sinusitis (AS) do not benefit from antibiotics, and GPs are under increasing pressure to reduce antibiotic prescribing. Concern about the risk of complications can drive unnecessary prescribing.

Aim: To describe the incidence of serious complications following AOM and AS, and to determine whether antibiotics are protective. Read More

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http://dx.doi.org/10.3399/bjgp20X708821DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065682PMC

Successful allogeneic stem cell transplantation in a case with acute myeloid leukemia and invasive Schizophyllum commune rhinosinusitis.

J Infect Chemother 2020 May 5;26(5):506-509. Epub 2020 Mar 5.

Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.

Schizophyllum commune, a basidiomycete fungus, is a quite rare cause of invasive sinusitis for which no standard treatment has yet been established. We report herein a 59-year-old woman who developed S. commune rhinosinusitis after remission induction chemotherapy for her acute myeloid leukemia. Read More

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http://dx.doi.org/10.1016/j.jiac.2019.12.013DOI Listing

Avoiding repeated surgery in patients with acute invasive fungal sinusitis.

Eur Arch Otorhinolaryngol 2020 Jun 3;277(6):1667-1674. Epub 2020 Mar 3.

Department of ENT (Rhinology and Anterior Skull Base Unit), Christian Medical College, Vellore, 632004, India.

Purpose: We aimed to ascertain whether using an aggressive initial surgical protocol would reduce the need for repeated sinus surgery in patients with acute invasive fungal sinusitis (AIFS).

Methods: Patients with AIFS prospectively underwent clinicoradiological assessment followed by bilateral functional endoscopic sinus surgery (FESS) and debridement of affected tissue. Antifungal therapy was also administered. Read More

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http://dx.doi.org/10.1007/s00405-020-05879-yDOI Listing

Choosing Wisely Canada rhinology recommendations.

J Otolaryngol Head Neck Surg 2020 Feb 28;49(1):10. Epub 2020 Feb 28.

Department of Otolaryngology - Head & Neck Surgery, University of Toronto, Mount Sinai Hospital, 600 University Avenue, Suite 404, Toronto, ON, M5G 1X5, Canada.

The Choosing Wisely Canada campaign is an initiative that aims to involve physicians and patients in collaborative decision making to avoid unnecessary tests and treatments. The Rhinology Subspecialty Group of the Canadian Society of Otolaryngology - Head & Neck Surgery developed a list of five evidence-based recommendations for the management of acute rhinosinusitis and nasal fractures: (1) don't prescribe antibiotics to patients with acute sinusitis who do not meet the diagnostic criteria for acute bacterial rhinosinusitis; (2) don't order a CT scan for uncomplicated acute rhinosinusitis; (3) don't order plain film sinus x-rays; (4) don't swab the nasal cavity as part of the work up for rhinosinusitis; and (5) don't order a plain film x-ray in the evaluation of nasal fractures. Read More

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http://dx.doi.org/10.1186/s40463-020-00406-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049188PMC
February 2020

Alternative therapies for sinusitis and rhinitis: a systematic review utilizing a modified Delphi method.

Int Forum Allergy Rhinol 2020 Apr 27;10(4):496-504. Epub 2020 Feb 27.

Rhinology, Sinus and Skull Base, Kentuckiana Ear, Nose, & Throat, Louisville, KY.

Background: Sinusitis and rhinitis are common diseases for which patients seek medical attention. Alternative therapies constitute a multibillion-dollar industry despite poorly established efficacy and safety profiles. This study was designed to identify and grade the evidence for alternative therapies purported to treat sinusitis and rhinitis. Read More

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http://dx.doi.org/10.1002/alr.22488DOI Listing

Pediatric Subperiosteal Abscess Secondary to Acute Sinusitis: A Systematic Review and Meta-analysis.

Laryngoscope 2020 Feb 17. Epub 2020 Feb 17.

Department of Otolaryngology and Communication Enhancement, Boston Children's Hospital, Boston, Massachusetts.

Objectives/hypothesis: The surgical versus medical management of subperiosteal abscess can be controversial. The purpose of this study was to summarize current literature and provide pooled analyses to help direct management decisions.

Study Design: Systematic review and meta-analysis. Read More

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http://dx.doi.org/10.1002/lary.28570DOI Listing
February 2020

Correlations in Trends of Sinusitis-Related Online Google Search Queries in the United States.

Am J Rhinol Allergy 2020 Jul 16;34(4):482-486. Epub 2020 Feb 16.

Department of Otolaryngology-Head and Neck Surgery, University of Louisville, Louisville, Kentucky.

Background: Online search query trends have been shown to correlate with real-life epidemiologic phenomena.

Objective: The aim of this study was to analyze correlations in trends in Google online search volumes of sinusitis-related terms, including symptomatology and similar disease states.

Methods: Terms clinically associated with "sinusitis" were determined by consensus. Read More

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http://dx.doi.org/10.1177/1945892420905761DOI Listing

Binding of pDNA with cDNA using hybridization strategy towards monitoring of Haemophilus influenza genome in human plasma samples.

Int J Biol Macromol 2020 May 10;150:218-227. Epub 2020 Feb 10.

Department of Nanotechnology, Faculty of Science and Chemistry, Urmia University, Urmia, Iran. Electronic address:

Haemophilus Influenza leads to respiratory infections such as sinusitis, acute otitis media, pneumonia and bronchitis. In addition, it causes invasive infections such as cellulite, septic arthritis, and meningitis. Therefore, quick and sensitive detection of H. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2020.02.062DOI Listing

Molecular Characterization of β-Lactam Resistant Streptococcus pneumoniae.

Clin Lab 2020 Jan;66(1)

Background: Streptococcus pneumoniae (S. pneumoniae) is a commensal bacterium that normally colonizes the human nasopharyngeal cavity. Once disseminated, it can cause several diseases, ranging from non-invasive infections such as acute otitis media and sinusitis through to invasive infections with higher mortality. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2019.190529DOI Listing
January 2020

Comprehensive assessment of respiratory complications in patients with common variable immunodeficiency.

Ann Allergy Asthma Immunol 2020 05 30;124(5):505-511.e3. Epub 2020 Jan 30.

Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Science, Tehran, Iran. Electronic address:

Background: Common variable immunodeficiency (CVID) is a heterogeneous group of disorders, characterized by recurrent upper and lower respiratory tract infections and some noninfectious clinical complications.

Objective: To provide a detailed evaluation of respiratory presentations and complications in a cohort of Iranian patients with CVID.

Methods: A retrospective cohort study was conducted on 245 CVID patients who were recorded in the Iranian primary immunodeficiency disorders registry network. Read More

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http://dx.doi.org/10.1016/j.anai.2020.01.019DOI Listing
May 2020
2.599 Impact Factor

Toxicity evaluation and nasal mucosal tissue deposition of dexamethasone-infused mucoadhesive nasal gelling systems.

Saudi Pharm J 2019 Nov 28;27(7):914-919. Epub 2019 Jun 28.

School of Pharmacy, Pharmacy Australia Centre of Excellence, The University of Queensland, Brisbane, Australia.

To demonstrate safety of a developed intranasal dexamethasone-infused gelling formulation, quantification of a validated clinical biomarker indicative of cytotoxic potential using a human sinonasal explant model was first confirmed. Systematic cytotoxicity studies using the lactate dehydrogenase (LDH) detection assay revealed no elevation from baseline, in LDH levels, with tissue integrity of explanted human nasal mucosa also maintained; this was further corroborated using tissue histopathological examination. Next, with safety confirmed , freshly excised human nasal tissue was utilised to quantify dexamethasone release from the lead sol-gel systems; this being achieved through development and validation of a HPLC-UV analytical method, which reliably quantified controlled therapeutic release and deposition into mucosal tissue. Read More

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http://dx.doi.org/10.1016/j.jsps.2019.06.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6978612PMC
November 2019

Identification and Recent Approaches for Evaluation and Management of Dentofacial and Otolaryngologic Concerns for Patients With Freeman-Burian Syndrome: Principles for Global Treatment.

J Craniofac Surg 2020 May/Jun;31(3):787-790

Private Practice, Fairfax, VA.

Freeman-Burian syndrome (FBS), formerly Freeman-Sheldon syndrome, is a complex myopathic craniofacial syndrome. Functional craniofacial deformities resulting in respiratory, eating, auditory, or speech impairments often are present to varying degrees in this unique population. There are few references in the literature addressing diagnosis, evaluation, operative counseling, and craniofacial management of FBS, and guidance was absent. Read More

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http://dx.doi.org/10.1097/SCS.0000000000006155DOI Listing
January 2020
0.676 Impact Factor

A case of acute unilateral maxillary atelectasis following endoscopic pituitary surgery.

Int J Surg Case Rep 2020 14;66:394-397. Epub 2020 Jan 14.

Department of Otolaryngology Head and Neck Surgery, Westmead Hospital, Sydney, Australia; Sydney Medical School, The University of Sydney, Sydney, Australia.

Introduction: Chronic maxillary atelectasis (CMA) is traditionally described as a rare, acquired condition of persistent and progressive antral wall collapse causing a reduction in maxillary sinus volume. In a handful of cases, CMA has been identified in patients with previously normal computed tomography (CT) imaging. However, maxillary atelectasis occurring rapidly after pituitary surgery, despite a normal pre-operative CT scan, has not previously been described in the literature. Read More

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http://dx.doi.org/10.1016/j.ijscr.2019.12.041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6974698PMC
January 2020

What are the challenges in choosing pharmacotherapy for rhinosinusitis?

Expert Opin Pharmacother 2020 Mar 23;21(4):427-433. Epub 2020 Jan 23.

Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Vienna, Vienna, Austria.

: Rhinosinusitis is an extremely prevalent condition with significant health-care expenditure and socio-economic burden. Although symptomatically patients with acute and chronic rhinosinusitis present similarly, the underlying pathogenesis of these conditions is different.: This perspective discusses the various treatment options for both acute and chronic rhinosinusitis and examines some of the challenges in choosing appropriate pharmacotherapy. Read More

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http://dx.doi.org/10.1080/14656566.2020.1717467DOI Listing

Air flight barotrauma and meningitis: causality seems real.

J Laryngol Otol 2020 Jan 22:1-3. Epub 2020 Jan 22.

Department of Infectious Diseases, Charles University in Prague, Third Faculty of Medicine, Prague, Czech Republic.

Background: Barotrauma to the middle-ear cavity and paranasal sinuses is a relatively common flight-related health problem. Occasionally, it may result in severe mechanical or infectious intracranial complications; these have been rarely reported to date.

Objective: Four cases of acute bacterial meningitis following air travel are presented, and its pathogenesis is briefly described. Read More

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http://dx.doi.org/10.1017/S0022215120000110DOI Listing
January 2020

Aspirin desensitization therapy in aspirin-exacerbated respiratory disease: a systematic review.

Int Forum Allergy Rhinol 2020 Apr 16;10(4):450-464. Epub 2020 Jan 16.

Dalhousie Medicine New Brunswick, Saint John, NB, Canada.

Background: Aspirin-exacerbated respiratory disease (AERD) represents an aggressive form of chronic rhinosinusitis with nasal polyposis that is notoriously challenging to treat. There is evidence to suggest desensitization to aspirin may improve symptomatology and disease control in these patients. The goal of our study was to critically appraise the literature on this topic and assess the effect of desensitization on sinonasal symptomatology. Read More

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http://dx.doi.org/10.1002/alr.22520DOI Listing