29,723 results match your criteria Sinusitis


Calprotectin in nasal secretion: a new biomarker of non-type 2 inflammation in CRSwNP.

Acta Otorhinolaryngol Ital 2022 Jun 30. Epub 2022 Jun 30.

A. Gemelli Hospital Foundation IRCCS, Unit of Otorhinolaryngology, Head and Neck Surgery, Rome, Italy.

Objective: We analysed calprotectin in sinonasal secretions of different chronic rhinosinusitis with nasal polyps (CRSwNP) endotypes to assess its role as a biomarker of non-type 2 inflammation.

Methods: We included primary diffuse CRSwNP patients (n = 41) and three different control groups [non-allergic rhinitis (NAR) (n = 13), non-allergic eosinophilic syndrome (NARES) (n = 10) and healthy subjects (n = 12)]. Calprotectin levels were detected in nasal secretions using a chemiluminescent immunoassay (CLIA). Read More

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Invasive Fungal Sinusitis During Active COVID-19 Infection.

Ear Nose Throat J 2022 Jun 30:1455613221112337. Epub 2022 Jun 30.

Sinus Center of Excellence, 22494Cedars Sinai, Los Angeles, CA, USA.

This case study demonstrates a 58-year-old female who contracted COVID-19 post-vaccination presenting with severe left-sided facial pain, headaches, and dyspnea. A computed tomography was ordered and showed acute sinusitis, and upon bedside endoscopy, the patient was shown to have necrosis of the left-sided middle turbinate with no discoloration, palate necrosis, or facial changes. All samples of the necrotic tissue were reported to be invasive fungal sinusitis. Read More

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Case Report: Rare Dynein Axonemal Heavy Chain 9 Mutations in a Han-Chinese Patient With Kartagener Syndrome.

Front Med (Lausanne) 2022 13;9:893968. Epub 2022 Jun 13.

Department of Pulmonary and Critical Care Medicine, Shanghai Fifth People's Hospital, Center of Community-Based Health Research, Fudan University, Shanghai, China.

A 52-year-old woman presented with respiratory symptoms of productive cough and shortness of breath. She had suffered from repeated pneumonia. The CT scans revealed chronic sinusitis, tree bud signs in pulmonary imaging, and situs inversus. Read More

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Odontogenic maxillary sinusitis and fungus ball development secondary to a dental root retained for more than 25 years. A case report.

J Clin Exp Dent 2022 Jun 1;14(6):e510-e513. Epub 2022 Jun 1.

MD, DDS, MS, PhD, EBOS, OMFS. Chairman and Professor of the Department of Oral and Maxillofacial Surgery, Faculty of Medicine and Health Sciences, School of Dentistry, University of Barcelona. Director of the Master's Degree Program in Oral Surgery and Implantology, EFHRE International University/FUCSO, Barcelona. Coordinator/researcher of the IDIBELL Institute. Head of the Department of Oral and Maxillofacial Surgery and Implantology, Teknon Medical Center, Barcelona (Spain).

The displacement of a dental root fragment into the maxillary sinus is a serious complication of tooth extraction that can give rise to maxillary sinusitis. The condition can become chronic if the intrasinusal foreign body is not promptly removed, and Aspergillus fumigatus superinfection may ultimately result, forming a fungus ball. The present study describes the case of a 50-year-old man with fungal rhinosinusitis caused by the accidental displacement of a dental root over 25 years ago. Read More

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Purely Endonasal Endoscopic Approaches for Extracranial Trigeminal Nerve Schwannoma.

J Craniofac Surg 2022 Jun 29. Epub 2022 Jun 29.

Department of Otorhinolaryngology Head and Neck Surgery, Ankara University Faculty of Medicine, Ankara, Turkey.

Objective: The aim of this study is to assess the effectiveness and safety of purely endonasal endoscopic resection of extracranial trigeminal schwannomas (TGSs), with assessment of surgical and clinical outcomes in order to identify optimal candidates for an endonasal endoscopic approach (EEA).

Methods: A retrospective review of patient's records operated for TGSs between 2008 and 2021 was conducted. Patients operated with a purely EEA were included in this study. Read More

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Real-life effectiveness of dupilumab in patients with mild to moderate bronchial asthma comorbid with CRSwNP.

BMC Pulm Med 2022 Jun 28;22(1):258. Epub 2022 Jun 28.

Matsuwaki Clinic Shinagawa, 6-7-29 Kitashinagawa Shinagawa-ku, Tokyo, 140-0001, Japan.

Background: Dupilumab, an anti-IL-4α receptor antibody, is a new treatment for severe or refractory asthma. However, real-world evidence on the efficacy of dupilumab in patients with mild to moderate bronchial asthma is lacking.

Methods: We retrospectively evaluated the effects of dupilumab in 62 patients who received dupilumab for eosinophilic sinusitis comorbid with asthma at a single centre in Japan. Read More

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Characterization of fungus ball CT-hyperdensities within maxillary and sphenoid sinuses.

Dentomaxillofac Radiol 2022 Jun 28:20180384. Epub 2022 Jun 28.

Department of Otorhinolaryngology-Head and Neck Surgery, University Hospital of Bordeaux, Bordeaux, France.

Objectives: CT-Scan hyperdensities are described in more than 60% of all paranasal sinus fungus ball cases. Two types can be distinguished according to their density: calcium and metal types. We aimed to establish the prevalence and density of the hyperdensities observed in sphenoid and maxillary sinus fungus ball and their relation to dental factors. Read More

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Computed Tomography Assessment of Maxillary Sinus and Inferior Nasal Airway After Le Fort I Osteotomy.

J Craniofac Surg 2022 Jun 28. Epub 2022 Jun 28.

Department of Oral and Maxillofacial Surgery, Division of Medicine, Interdisciplinary Graduate School, University of Yamanashi, Chuoshi, Japan.

Purpose: This study aimed to evaluate and predict the factors that affect the postoperative maxillary sinus and inferior nasal cavity conditions after Le Fort I osteotomy.

Subjects And Methods: The rate of aerated (healthy) sinus area and the inferior nasal airway area were calculated by preoperative computed tomography measurements and at 1 week and 1 year postoperatively. Factors predicting the rate of aerated sinus area and the ratio of the inferior nasal cavity area after 1-week were examined using these variables. Read More

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Prevalence and comorbidities of bronchiolitis in adults: A population-based study in South Korea.

Medicine (Baltimore) 2022 Jun 24;101(25):e29551. Epub 2022 Jun 24.

Department of Internal Medicine, Research Center for Pulmonary Disorders, Jeonbuk National University Medical School, Jeonju, South Korea.

Abstract: Bronchiolitis generally refers to inflammation and/or fibrosis of the non-cartilaginous small airways located approximately from the 8th airway generation down to the terminal and respiratory bronchioles. In contrast to young children, the frequency of small airway infection in adult bronchiolitis appears less frequent and a number of other pathophysiological conditions have been implicated in adult bronchiolitis. However, little information is available on the exact medical burden of bronchiolitis such as its prevalence and comorbidities in the adult population. Read More

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Surgical endodontic treatment for odontogenic maxillary sinusitis caused by radicular cyst of maxillary anterior teeth: A case report.

J Dent Sci 2022 Apr 5;17(2):1048-1049. Epub 2022 Jan 5.

Section of Operative Dentistry and Endodontology, Department of Odontology, Fukuoka Dental College, Fukuoka, Japan.

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Serum IL-5, POSTN and IL-33 levels in chronic rhinosinusitis with nasal polyposis correlate with clinical severity.

BMC Immunol 2022 Jun 25;23(1):33. Epub 2022 Jun 25.

Department of Allergology and Respiratory Rehabilitation, Medical University of Lodz, 90-725, Lodz, Poland.

Background: Chronic rhinosinusitis (CRS) is a group of heterogeneous diseases characterized by epithelial inflammation and tissue eosinophilic infiltration. IL-5, POSTN, and IL-33 are important factors that act as chemoattractants for eosinophils, and a tissue-remodeling protein positively correlated with eosinophils in blood and mediators of eosinophilic infiltration. The aim of the study was to determine the expression of IL-5, POSTN and IL-33, at the gene and protein levels, in eosinophilic CRS with nasal polyps (CRSwNP) and without nasal polyps (CRSsNP), and to correlate this expression with clinical severity. Read More

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Endoscopic endonasal retrieval of air gun pellet retained in the frontal sinus: A case report.

Int J Surg Case Rep 2022 Jun 6;96:107280. Epub 2022 Jun 6.

Department of Otolaryngology-Head and Neck Surgery, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.

Introduction And Importance: Foreign bodies in paranasal sinuses are rarely encountered and most commonly present in the maxillary sinus. Guidelines for managing paranasal sinus object removal are limited due to its rarity. However, there are three major management options: open surgery, endoscopic sinus surgery, and observation. Read More

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Analysis of neutrophil functional activity in patients with chronic polyposis rhinosinusitis after treatment with interferon gamma.

Klin Lab Diagn 2022 Jun;67(6):339-344

Penza Institute for Further Training of Physicians - Branch Campus of the Federal State Budgetary Educational Institution of Further Professional Education «Russian Medical Academy of Continuing Professional Education» of the Ministry of Healthcare of the Russian Federation.

Chronic polyposis rhinosinusitis (CPRS) is an inflammatory disease of the nose and paranasal sinuses, accompanied by the formation and recurrent growth of polyps. PDRS is an urgent medical problem, because it is difficult to treat and is accompanied by constant exacerbations. The important role of neutrophil granulocytes in the pathogenesis of CPRS has been proved, as they are the first line of defense in response to tissue damage and active participants in the pathological process. Read More

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The Roles of Autophagy, Mitophagy, and the Akt/mTOR Pathway in the Pathogenesis of Chronic Rhinosinusitis with Nasal Polyps.

J Immunol Res 2022 14;2022:2273121. Epub 2022 Jun 14.

Department of Otolaryngology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

The pathogenesis of CRSwNP is complex and unclear. CRSwNP is subdivided into two types based on the infiltration of EOSs: eCRSwNP and noeCRSwNP. This study was designed to seek the role of autophagy, mitophagy, and Akt/mTOR pathway in these two subtypes of CRSwNP. Read More

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Recurrent Optic Perineuritis With Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease Complicated With Granulomatous Polyangiitis.

Cureus 2022 May 23;14(5):e25239. Epub 2022 May 23.

Division of Hematology and Rheumatology, Teikyo University Chiba Medical Center, Ichihara, JPN.

Optic perineuritis (OPN) is an intraorbital inflammatory disease that targets the optic nerve sheath, which can cause severe vision loss. OPN has been recently reported to be sometimes caused by myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD). MOGAD is rarely reported to be complicated with other autoimmune diseases. Read More

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-Cause of Nonspecific Acute Sinusitis: First Case Report and Review of Literature.

Microorganisms 2022 Jun 9;10(6). Epub 2022 Jun 9.

Department of Clinical Microbiology, Clinical Hospital Center Rijeka, Krešimirova 42, 51000 Rijeka, Croatia.

Although most sinus infections are viral, potential bacterial pathogens such as , and can migrate during a viral respiratory infection from the nasopharynx into the sinus cavity causing sinusitis. is a commensal of the external auditory canal and is considered one of the potential middle ear pathogens. Unlike most otopathogens, is rarely found in the nasopharynx of healthy individuals. Read More

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May   Be an Etiological Factor of Chronic Maxillary Sinuses Infection?

Int J Mol Sci 2022 Jun 9;23(12). Epub 2022 Jun 9.

MML Centre, Bagno 2, 00-112 Warsaw, Poland.

  is an opportunistic pathogen found in the healthy human skin microbiome bacterial community that is able to cause infections of diverse localization, manifestation, and course, including laryngological infections, such as necrotizing sinusitis. Chronic maxillary sinusitis is a disease present in up to one third of European and American populations, and its etiology is not fully described. Within this study, we aimed to characterize 18 strains recovered from maxillary sinuses and evaluate them as etiological agents of chronic disease. Read More

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Retrospective Analysis of Treatment Outcomes of Maxillary Sinusitis Associated with Medication-Related Osteonecrosis of the Jaw.

Int J Environ Res Public Health 2022 Jun 17;19(12). Epub 2022 Jun 17.

Department of Clinical Oral Oncology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8588, Japan.

Although maxillary sinusitis often occurs in patients with medication-related osteonecrosis of the jaw (MRONJ) of the upper jaw, there have been few reports on the treatment and outcomes for maxillary sinusitis associated with maxillary MRONJ. This study aimed to retrospectively investigate the treatment outcomes of maxillary sinusitis in patients with MRONJ of the upper jaw. There were 34 patients diagnosed with maxillary MRONJ and sinusitis by preoperative computed tomography who underwent surgery in our institution between January 2011 and December 2019. Read More

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Solid Anorganic Particles and Chronic Rhinosinusitis: A Histopathology Study.

Int J Environ Res Public Health 2022 Jun 14;19(12). Epub 2022 Jun 14.

Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Ostrava, 708 52 Ostrava, Czech Republic.

Although extensive research has shown the pathological effect of fine and ultrafine airborne particles, clear evidence of association of environmental exposure to them and inflammatory changes in human nasal mucosa is missing. Meanwhile, pathogenesis of chronic rhinosinusitis, despite being a disease with high prevalence in the population, is still unclear. The increasing evidence of the pro-inflammatory properties of these particles raises the question of their possible role in chronic rhinosinusitis. Read More

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Expression of Apoptosis-Related Biomarkers in Inflamed Nasal Sinus Epithelium of Patients with Chronic Rhinosinusitis with Nasal Polyps (CRSwNP)-Evaluation at mRNA and miRNA Levels.

Biomedicines 2022 Jun 13;10(6). Epub 2022 Jun 13.

Department of Otolaryngology, Head and Neck Surgery, Wroclaw Medical University, Borowska 213, 50-556 Wroclaw, Poland.

In chronic upper respiratory tract diseases, increased cell proliferative activity is observed, which is coordinated by BCL-2 proteins and small non-coding RNAs. This study aimed to determine the expression of critical apoptosis markers at the mRNA and miRNA levels in patients with chronic rhinosinusitis with nasal polyps (CSRwNP). The study group consisted of ten patients with CSRwNP and ten healthy subjects. Read More

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The Role of Epithelial-Mesenchymal Transition in Chronic Rhinosinusitis.

Int Arch Allergy Immunol 2022 Jun 23:1-11. Epub 2022 Jun 23.

Department of Otolaryngology/Head and Neck Surgery, Ninth School of Clinical Medicine, Peking University, Beijing, China.

Background: Chronic rhinosinusitis (CRS) is a common condition in otorhinolaryngology. It is characterized by chronic inflammation of the nasal cavity and the sinus mucosa. However, its specific pathogenesis remains unclear. Read More

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Complications of sinus floor elevation procedure and management strategies: A systematic review.

Clin Implant Dent Relat Res 2022 Jun 23. Epub 2022 Jun 23.

Department of Periodontics and Dental Hygiene, University of Texas Health Science Center at Houston, Houston, Texas, USA.

Aim: This systematic review aimed to investigates the types and incidences of complications following sinus floor elevations (SFE) along with their prevention and management strategies.

Materials And Methods: Electronic database and hand search were conducted to screen the literature published from January 1960 to June 2021. The selected studies had to report well-described SFE techniques, complications during, and post-SFE. Read More

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Intracranial complications of hypercoagulability and superinfection in the setting of COVID-19: illustrative cases.

J Neurosurg Case Lessons 2022 May 23;3(21):CASE22127. Epub 2022 May 23.

Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

Background: Hypercoagulability with thrombosis and associated inflammation has been well-documented in COVID-19, and catastrophic cerebral venous sinus thromboses (CVSTs) have been described. Another COVID-19-related complication is bacterial superinfection, including sinusitis. Here, the authors reported three cases of COVID-19-associated sinusitis, meningitis, and CVST and summarized the literature about septic intracranial thrombotic events as a cause of headache and fever in COVID-19. Read More

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Solitary Sphenoid Sinus Lesion Presenting as Chronic Headache.

J Craniofac Surg 2022 May;33(3):886-888

Department of Otolaryngology-Head and Neck Surgery, Kosin University College of Medicine, Busan, South Korea.

Background And Objectives: Headache is a common symptom with etiologies that are difficult to distinguish, 1 of which is sinusitis. A solitary sphenoid lesion, which is rare, can also cause acute or chronic headaches. The authors investigated whether endoscopic sinus surgery (ESS) for solitary sphenoid lesions could reduce headache symptoms. Read More

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Activation of STAT6 by intranasal allergens correlated with the development of eosinophilic chronic rhinosinusitis in a mouse model.

Int J Immunopathol Pharmacol 2022 Jan-Dec;36:3946320221109529

Department of Otorhinolaryngology, 74566The First Affiliated Hospital of Soochow University, Suzhou, China.

Eosinophilic chronic rhinosinusitis (ECRS) is a chronic inflammatory disease characterized by prominent eosinophilic infiltration along with a T-helper-2 (Th2) response. It has been well documented that signal transducer and activator of transcription 6 (STAT6) is a nuclear transcription factor that mediates Th2-type immunity and is implicatory of STAT1 and STAT3 in the pathogenesis of allergic airway diseases. However, little is known about the association between STATs and ECRS. Read More

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[Research advances in endotypes and precision medicine of chronic rhinosinusitis].

Authors:
X H Chen G H Zhang

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2022 Jun;57(6):783-788

Department of Otorhinolaryngology Head and Neck Surgery, the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510630, China.

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[Research progress of extracellular vesicles in chronic rhinosinusitis and allergic rhinitis].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2022 Jun;57(6):778-782

Department of Otorhinolaryngology Head and Neck Surgery, Affiliated Hospital of Nantong University, Institute of Otorhinolaryngology Head and Neck Surgery, Affiliated Hospital of Nantong University, Nantong 226001, China.

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[The expression profile and potential regulatory mechanism of ACE2 in chronic rhinosinusitis with nasal polyps].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2022 Jun;57(6):692-698

Department of Otorhinolaryngology Head and Neck Surgery, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.

To preliminarily analyze the expression of angiotensin-converting enzyme 2 (ACE2) and to investigate its potential regulatory mechanism in chronic rhinosinusitis with nasal polyps (CRSwNP). Patients underwent nasal endoscopic surgery in the Third Affiliated Hospital of Sun Yat-sen University from February 2020 to May 2021 were selected, including 17 males and 6 females, aging from 23 to 66 years old. Expression of ACE2 was evaluated via immunohistochemical staining in controls with non-chronic rhinosinusitis, non-eosinophilic CRSwNP (non-ECRSwNP), and eosinophilic CRSwNP (ECRSwNP) tissue, respectively. Read More

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[Analysis of relationship between distribution of pathogenic microorganisms in olfactory cleft and olfactory disorders among patients with upper respiratory inflammation during the prevention and control of COVID-19].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2022 Jun;57(6):683-691

Department of Otorhinolaryngology Head and Neck Surgery, Capital Institute of Pediatrics, Beijing 100020, China.

To explore the relationship between pathogens in the olfactory cleft area and olfactory disorders in patients with upper respiratory inflammation (URI) during the prevention and control of 2019 novel coronavirus disease (COVID-19). A total of 234 URI patients including acute upper respiratory infection, chronic rhinosinusitis (CRS), allergic rhinitis (AR) were continuously selected from September 2020 to March 2021 in Beijing Anzhen Hospital and 98 healthy adults were enrolled as controls. The secretions from the olfactory cleft of all subjects were collected with nasal swabs under nasal endoscopy. Read More

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The diagnostic importance of periostin as a biomarker in chronic rhinosinusitis with nasal polyp.

Eur Arch Otorhinolaryngol 2022 Jun 20. Epub 2022 Jun 20.

Department of Otorhinolaryngology, Antalya Training and Research Hospital, Antalya, Turkey.

Purpose: The current studies in the literature report that periostin contributes to the formation of nasal polyps and may be a molecular biomarker for chronic rhinosinusitis with nasal polyps (CRSwNP). This study aims to investigate the effect of periostin in determining polyp burden in CRSwNP patients and evaluate its impact on postoperative surgical results and its functionality as a biomarker.

Methods: The study included 26 patients who underwent endoscopic sinus surgery due to CRSwNP and 30 patients who were scheduled to undergo septoplasty due to isolated nasal septum deviation. Read More

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