5,044 results match your criteria Sinus Node Dysfunction


Unexpected Rapid Pacing on ECG: Has the device malfunctioned?

J Cardiovasc Electrophysiol 2020 Jul 9. Epub 2020 Jul 9.

Department of Cardiology, Tan Tock Seng Hospital, Singapore, 11 Jalan Tan Tock Seng, Singapore, 308433.

An 80-year-old female with a history of paroxysmal atrial fibrillation (AF), sick sinus syndrome and chronotropic incompetence had a dual-chamber permanent pacemaker implanted in 2013 (Abbott Sustain™ XL DC PM2134). She presented with sudden onset of palpitations to the Emergency Department. The following 12-lead electrocardiogram (ECG) (Figure 1) was captured. Read More

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http://dx.doi.org/10.1111/jce.14663DOI Listing

Electrophysiological Characteristics and Outcomes of Radiofrequency Catheter Ablation of Atrial Flutter in Children with or Without Congenital Heart Disease.

Pediatr Cardiol 2020 Jul 8. Epub 2020 Jul 8.

Department of Pediatric Cardiology, Heart Center, the First Hospital of Tsinghua University, Beijing Huaxin Hospital, No.6 Jiuxianqiao 1st Road, Chaoyang District, Beijing, 100016, China.

There are scarce studies on radiofrequency catheter ablation (RFCA) of atrial flutter (AFL) in the pediatric population. This study therefore aimed to investigate the clinical features and RFCA of AFL in children with or without congenital heart disease. Data from 72 consecutive children (44 males; mean age, 6. Read More

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http://dx.doi.org/10.1007/s00246-020-02406-yDOI Listing

Simultaneous epicardial-endocardial mapping of the sinus node in humans with structural heart disease: Impact of overdrive suppression on sino-atrial exits.

Heart Rhythm 2020 Jul 2. Epub 2020 Jul 2.

Department of Cardiology, Royal Melbourne Hospital, 300 Grattan Street, Parkville, Victoria 3010, Australia; University of Melbourne, Grattan Street, Parkville, Victoria 3010, Australia. Electronic address:

Background: The 3-dimensional nature of sino-atrial node (SAN) function has not previously been characterised in the intact human heart.

Objective: To characterize the 3-dimensional nature of SAN function in patients with structural heart disease (SHD) using simultaneous endocardial-epicardial phase mapping.

Methodology: Simultaneous intra-op endo-epicardial SAN mapping was performed during sinus rhythm at baseline (SR) and post-overdrive suppression at 600ms (SR) and 400ms (SR) using two HD Grid catheters. Read More

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http://dx.doi.org/10.1016/j.hrthm.2020.06.034DOI Listing

Adults with Congenital Heart Disease and Arrhythmia Management.

Cardiol Clin 2020 Aug 7;38(3):417-434. Epub 2020 Jun 7.

Electrophysiology Service and Adult Congenital Heart Disease Center; Department of Medicine, Montreal Heart Institute, Université de Montréal, 5000 Bélanger Street, Montreal, Quebec H1T 1C8, Canada.

Arrhythmia management in adult congenital heart disease (ACHD) encompasses a wide range of problems from bradyarrhythmia to tachyarrhythmia, sudden death, and heart failure-related electrical dyssynchrony. Major advances in the understanding of the pathophysiology and treatments of these problems over the past decade have resulted in improved therapeutic strategies and outcomes. This article attempts to define these problems and review contemporary management for the patient with ACHD presenting with cardiac arrhythmia. Read More

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http://dx.doi.org/10.1016/j.ccl.2020.04.006DOI Listing

Headache and sick sinus syndrome: A case report.

World J Clin Cases 2020 Jun;8(12):2629-2633

Department of Neurology, Chengdu Second People's Hospital, Chengdu 650017, Sichuan Province, China.

Background: Sick sinus syndrome is a common disease in cardiology. Typical symptoms include palpitations, dizziness, shortness of breath, chest tightness, and amaurosis. However, to date, there are no known reports of sick sinus syndrome presenting with headache. Read More

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http://dx.doi.org/10.12998/wjcc.v8.i12.2629DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322413PMC

Increasing atrial fibrillation: what is the cause?

J Cardiovasc Electrophysiol 2020 Jun 30. Epub 2020 Jun 30.

Texas Cardiac Arrhythmia Institute, St. David's Medical Center, Austin, TX, USA.

A 72-year-old woman with a history of paroxysmal atrial fibrillation (AF) and sinus node dysfunction is seen in clinic for routine follow-up. She had undergone radiofrequency ablation for AF and a dual chamber pacemaker implant (Medtronic Advisa DR MRI with 5076 active fixation leads; Medtronic, Minneapolis, MN, United States) five years prior. This article is protected by copyright. Read More

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http://dx.doi.org/10.1111/jce.14642DOI Listing

Channelopathies of voltage-gated L-type Cav1.3/α and T-type Cav3.1/α Ca channels in dysfunction of heart automaticity.

Pflugers Arch 2020 Jun 29. Epub 2020 Jun 29.

Institut de Génomique Fonctionnelle, Université de Montpellier, CNRS, INSERM, 141, rue de la cardonille, 34094, Montpellier, France.

The heart automaticity is a fundamental physiological function in vertebrates. The cardiac impulse is generated in the sinus node by a specialized population of spontaneously active myocytes known as "pacemaker cells." Failure in generating or conducting spontaneous activity induces dysfunction in cardiac automaticity. Read More

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http://dx.doi.org/10.1007/s00424-020-02421-1DOI Listing

Inhibition of G protein-gated K channels by tertiapin-Q rescues sinus node dysfunction and atrioventricular conduction in mouse models of primary bradycardia.

Sci Rep 2020 Jun 17;10(1):9835. Epub 2020 Jun 17.

IGF, Univ. Montpellier, CNRS, INSERM, Montpellier, France.

Sinus node (SAN) dysfunction (SND) manifests as low heart rate (HR) and is often accompanied by atrial tachycardia or atrioventricular (AV) block. The only currently available therapy for chronic SND is the implantation of an electronic pacemaker. Because of the growing burden of SND in the population, new pharmacological therapies of chronic SND and heart block are desirable. Read More

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http://dx.doi.org/10.1038/s41598-020-66673-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7300035PMC

Epicardial pacemaker implantation for sick sinus syndrome in a patient with supra vena cava obstructed by a primary cardiac lymphoma.

J Cardiol Cases 2020 Jun 18;21(6):234-237. Epub 2020 Apr 18.

Department of Cardiology, Tokyo Metropolitan Tama Medical Center, Tokyo, Japan.

Primary cardiac lymphoma (PCL) involves the heart and pericardium. Symptoms may vary according to the cardiac site involved. The most frequent cardiac manifestations associated with PCL are pericardial effusion, heart failure, and atrioventricular block. Read More

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http://dx.doi.org/10.1016/j.jccase.2020.03.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283289PMC

Comparison of prognosis and safety of pacemaker implantation in patients aged less than or 85 years and older.

J Interv Card Electrophysiol 2020 Jun 12. Epub 2020 Jun 12.

Kansai Rosai Hospital Cardiovascular Center, 3-1-69 Inabaso, Amagasaki, Hyogo, 660-8511, Japan.

Purpose: Cardiac conduction disturbance necessitating pacemaker implantation is common among elderly patients. However, patients often have comorbidities and increased frailty which may result in limited life prognosis and a high rate of procedure-related complications. We evaluated pacemaker implantation in older patients by comparing life prognosis and complication rate in patients aged ≥ and < 85 years. Read More

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http://dx.doi.org/10.1007/s10840-020-00797-9DOI Listing

[Sinus node dysfunction, Brugada syndrome and long QT syndrome affecting the same patient : when genetics can't make head or tail of it].

Rev Med Suisse 2020 Jun;16(696):1148-1152

Service de cardiologie, Département cœur-vaisseaux, CHUV, 1011 Lausanne.

The gene SCN5A encodes the cardiac sodium channel which, through the conduction of Na+ current into the cell, generates the fast upstroke of the action potential of cardiomyocytes. Pathogenic variants of SCN5A have been causally associated to several hereditary cardiac diseases including, among others, Brugada syndrome, congenital long QT syndrome and sinus node dysfunction. Recently, overlap syndromes have been described that are characterized by the simultaneous expression of mixed clinical phenotypes among two or more hereditary cardiac diseases associated to the gene SCN5A (HCD-SCN5A). Read More

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Heart rate variability: Measurement and emerging use in critical care medicine.

J Intensive Care Soc 2020 May 11;21(2):148-157. Epub 2019 Jun 11.

University of Liverpool and The Royal Liverpool University Hospital, Liverpool Healthcare Partners, Liverpool, UK.

Variation in the time interval between consecutive R wave peaks of the QRS complex has long been recognised. Measurement of this RR interval is used to derive heart rate variability. Heart rate variability is thought to reflect modulation of automaticity of the sinus node by the sympathetic and parasympathetic components of the autonomic nervous system. Read More

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http://dx.doi.org/10.1177/1751143719853744DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238479PMC

A Review of Temporary Permanent Pacemakers and a Comparison with Conventional Temporary Pacemakers.

J Innov Card Rhythm Manag 2019 May 15;10(5):3652-3661. Epub 2019 May 15.

Section of Electrophysiology & Pacing, Division of Cardiology, Department of Medicine, Baylor Scott & White Temple Memorial Hospital, Baylor Scott & White Health, Dallas, TX, USA.

Temporary cardiac pacing is commonly used in patients with life-threatening bradycardia and serves as a bridge to implantation of a permanent pacemaker (PPM). For years, passive fixation leads have been used for this purpose, offering the advantage of that they can be placed at bedside. The downside, however, is that patients must remain on telemetry and bed rest until lead removal due to the risk of displacement and failure to capture. Read More

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http://dx.doi.org/10.19102/icrm.2019.100506DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7252718PMC

Nonpharmacological Treatment of Atrial Fibrillation: What Is the Role of Device Therapy?

Int J Angiol 2020 Jun 28;29(2):113-122. Epub 2020 Apr 28.

Department of Cardiology, Motol University Hospital, Prague, Czech Republic.

Atrial fibrillation is the most common arrhythmia in the adult population, and its incidence and prevalence are still rising. Cardiac devices are widely used in clinical practice in the management of various rhythm disturbances and heart failure treatment. Many patients who receive a pacemaker, implantable cardioverter-defibrillator, or cardiac resynchronization therapy also experience atrial fibrillation in the course of their life. Read More

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http://dx.doi.org/10.1055/s-0040-1708529DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250633PMC

Right Ventricular Perforation Presenting as Tingling of the Left Breast.

Cureus 2020 Apr 26;12(4):e7839. Epub 2020 Apr 26.

Internal Medicine, Citrus Memorial Hospital, Inverness, USA.

Pacemaker lead-associated cardiac perforation is a rare phenomenon. Lead perforations can be acute, subacute, or chronic following lead placement. Symptoms are typically nonspecific and depend on the location of the displaced lead. Read More

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http://dx.doi.org/10.7759/cureus.7839DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250524PMC

Factors that influence marital satisfaction in men with a heart rhythm disorders.

Aging Male 2020 May 28:1-7. Epub 2020 May 28.

Department of Electrocardiology, Upper Silesian Medical Centre, Katowice, Poland.

: A diagnosis of a cardiac arrhythmia can affect marital relations and diminish libido and satisfaction with a patient's sex life. The aim of the study was to assess the factors that affect marital satisfaction in men with an arrhythmias who had qualified for cardiac pacemaker implantation. The study included 103 men (aged 58. Read More

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http://dx.doi.org/10.1080/13685538.2020.1770211DOI Listing

The effect of forskolin on membrane clock and calcium clock in the hypoxic/reoxygenation of sinoatrial node cells and its mechanism.

Pharmacol Rep 2020 May 25. Epub 2020 May 25.

Provincial Clinical Medicine College of Fujian Medical University, No. 134 East Street, Gulou District, Fuzhou, Fujian, 350000, People's Republic of China.

Background: In this study, we investigated the effect of forskolin (FSK, a selective adenylate cyclase agonist) on the automatic diastolic depolarization of sinus node cells (SNC) with hypoxia/reoxygenation (H/R) injury.

Methods: The SNC of the newborn rat was randomly assigned into the control group, the H/R (H/R injury) group, or the H/R + FSK (H/R injury + FSK treatment) group. Patch-clamp was performed to record the action potential and electrophysiological changes. Read More

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http://dx.doi.org/10.1007/s43440-020-00094-2DOI Listing

Permanent pacemaker implantation rates following cardiac surgery in the modern era.

Ir J Med Sci 2020 May 22. Epub 2020 May 22.

Royal Victoria Hospital, Belfast Health and Social Care Trust, 274 Grosvenor Road, Belfast, BT12 6BA, UK.

Aims: The aim of this study was to evaluate the incidence of permanent pacemaker (PPM) implantation after cardiac surgery in our institution and investigate risk factors for PPM dependency to provide patients with accurate incidence figures at the time of consent for surgery.

Methods: Data was collected retrospectively from a single tertiary institution from October 2018 to April 2019 inclusive of 403 patients. Incidence of PPM implantation after various cardiac operations was evaluated. Read More

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http://dx.doi.org/10.1007/s11845-020-02254-yDOI Listing

Cardiac and neuronal HCN channelopathies.

Pflugers Arch 2020 May 18. Epub 2020 May 18.

School of Medicine and Surgery, Milan Center for Neuroscience (NeuroMI), University of Milano-Bicocca, Monza, Italy.

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are expressed as four different isoforms (HCN1-4) in the heart and in the central and peripheral nervous systems. In the voltage range of activation, HCN channels carry an inward current mediated by Na and K, termed I in the heart and I in neurons. Altered function of HCN channels, mainly HCN4, is associated with sinus node dysfunction and other arrhythmias such as atrial fibrillation, ventricular tachycardia, and atrioventricular block. Read More

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http://dx.doi.org/10.1007/s00424-020-02384-3DOI Listing

Benefit of Rate Response with Closed-Loop Stimulation in Patients with Difficult Hemodialysis.

Int Heart J 2020 May 15;61(3):611-615. Epub 2020 May 15.

Division of Cardiology, Department of Medicine, Nihon University School of Medicine.

Rate-responsive pacing is known to improve quality of life (QOL) in patients with sick sinus syndrome and chronotropic incompetence. However, the sensors for rate response include accelerometers, closed-loop stimulation (CLS), and minute ventilation sensors (MV sensors), each of which has a different mode of action. For this reason, it is important to select appropriate sensors that match the daily habits and behavioral patterns of the patient. Read More

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http://dx.doi.org/10.1536/ihj.19-545DOI Listing

Aging-associated sinus arrest and sick sinus syndrome in adult zebrafish.

PLoS One 2020 13;15(5):e0232457. Epub 2020 May 13.

Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, United States of America.

Because of its powerful genetics, the adult zebrafish has been increasingly used for studying cardiovascular diseases. Considering its heart rate of ~100 beats per minute at ambient temperature, which is very close to human, we assessed the use of this vertebrate animal for modeling heart rhythm disorders such as sinus arrest (SA) and sick sinus syndrome (SSS). We firstly optimized a protocol to measure electrocardiogram in adult zebrafish. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0232457PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7219707PMC

Is transjugular insertion of a temporary pacemaker a safe and effective approach?

PLoS One 2020 12;15(5):e0233129. Epub 2020 May 12.

Division of Cardiology, Department of Internal Medicine, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Temporary pacemakers (TPMs) are usually inserted in an emergency situation. However, there are few reports available regarding which route of access is best or what the most preferred approach is currently in tertiary hospitals. This study aimed to compare procedure times, complication rates, and indications for temporary pacing between the transjugular and transfemoral approaches to TPM placement. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0233129PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217466PMC
May 2020
3.234 Impact Factor

Atenolol's Inferior Ability to Reduce Central vs Peripheral Blood Pressure Can Be Explained by the Combination of Its Heart Rate-Dependent and Heart Rate-Independent Effects.

Int J Hypertens 2020 26;2020:4259187. Epub 2020 Apr 26.

Department of Cardiology, Institute of Clinical Medicine, University of Tartu, 8 Puusepa Street, Tartu 50406, Estonia.

Objective: Whether the inferior ability of atenolol to reduce central (aortic) compared to peripheral (brachial) blood pressure (BP) is related to its heart rate (HR)-dependent or -independent effects, or their combination, remains unclear. To provide further mechanistic insight into this topic, we studied the acute effects of atenolol versus nebivolol and ivabradine on systolic blood pressure amplification (SBPA; peripheral systolic BP minus central systolic BP) in a model of sick sinus syndrome patients with a permanent dual-chamber cardiac pacemaker in a nonrandomized single-blind single-group clinical trial.

Methods: We determined hemodynamic indices noninvasively (Sphygmocor XCEL) before and at least 3 h after administration of oral atenolol 50 or 100 mg, nebivolol 5 mg, or ivabradine 5 or 7. Read More

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http://dx.doi.org/10.1155/2020/4259187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201670PMC

Conduction Disorders: the value of Surface ECG.

Curr Cardiol Rev 2020 May 10. Epub 2020 May 10.

Department of Internal Medicine, Faculty of Medicine, University of Minas Gerais Hospital das Clínicas, Federal, Belo Horizonte/Minas Gerais. Brazil.

Purpose Of Review: The purpose of the current mini-review is to describe the importance of surface ECG for the diagnosis of conduction disorder.

Methods: The MEDLINE/PubMed database was used, with the keywords 'ECG' and 'conduction disorders'; over the past 10 years. Other documents were included because of their relevance. Read More

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http://dx.doi.org/10.2174/1573403X16666200511090151DOI Listing

[Indications for His bundle and left bundle branch pacing].

Herzschrittmacherther Elektrophysiol 2020 Jun;31(2):135-143

Abteilung für Elektrophysiologie, Herzzentrum Leipzig und Universität Leipzig, Leipzig, Deutschland.

His bundle pacing (HBP) allows ventricular excitation through the entire cardiac conduction system, resulting in a better synchronicity and efficacy of contraction compared to myocardial pacing. Due to better, dedicated implantation tools and exact practical implantation recommendations, HBP has developed into a form of stimulation that can be successfully applied with reasonable time and effort in >90% of patients. The rate of lead dislodgement and threshold increase is similar to conventional pacemaker systems. Read More

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http://dx.doi.org/10.1007/s00399-020-00689-5DOI Listing

Possible Lyme Carditis with Sick Sinus Syndrome.

IDCases 2020 8;20:e00761. Epub 2020 Apr 8.

California State University, Los Angeles, United States.

() is a spirochete bacterium that is transmitted via the tick. Infection results in Lyme disease with possible cardiac manifestations, which is also known as Lyme carditis. Patients can present with bradycardia due to rapidly fluctuating atrioventricular block (AVB), which is the hallmark of Lyme carditis. Read More

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http://dx.doi.org/10.1016/j.idcr.2020.e00761DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7190756PMC

Comparison of safety and outcomes with two approaches to the mitral valve.

J Card Surg 2020 May 4. Epub 2020 May 4.

Department of Surgery, Faculty of Medicine, Damascus University, Damascus, Syrian Arab Republic.

Background And Aim: The efficacy of the superior trans-septal (STS) approach to the mitral valve has been offset by the perceived risks of adverse postoperative events. The aim of this study was to review our experience with using the left atriotomy (LA) and STS approaches in patients undergoing mitral valve surgery.

Methods: Charts of patients who underwent mitral valve surgery by a single surgeon over a period of 20 years were reviewed retrospectively. Read More

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http://dx.doi.org/10.1111/jocs.14603DOI Listing

Surgical Treatment of Primary Cardiac Tumor Associated with Malignant Arrhythmias.

Heart Surg Forum 2020 03 31;23(2):E178-E182. Epub 2020 Mar 31.

Heart Center, The First Hospital of Tsinghua University (Beijing Huaxin Hospital), Beijing, China.

Objective: Pediatric primary cardiac tumor is an extremely rare disease. The tumor can extend into the conduction system and cause malignant arrhythmias. We retrospectively reviewed 6 consecutive cases of children with primary cardiac tumor that manifested as rhythm disturbance. Read More

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http://dx.doi.org/10.1532/hsf.2823DOI Listing
March 2020
0.562 Impact Factor

Glossopharyngeal Neuralgia/Neuropathy with Hemodynamic Instability and Associated Syncope Treated with Stereotactic Radiosurgery.

World Neurosurg 2020 Apr 25;139:314-317. Epub 2020 Apr 25.

Department of Neurosurgery, Medical College of Georgia, Augusta University, Augusta, Georgia, USA.

Background: Glossopharyngeal neuralgia/neuropathy is rare, and less than 3% of cases involve cardiac arrhythmias of syncope due to activated vagal reflex pathways. Most of these cases are successfully treated with medical management with or without pacemaker placement. We present the first reported case of glossopharyngeal neuralgia/neuropathy with cardiac symptoms refractory to medical management including pacemaker placement but successfully treated with Gamma Knife Radiosurgery. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.04.130DOI Listing

Atrial involvement and progression of sinus node dysfunction in non-senile patients: evidences from electroanatomic mapping and long-term follow-up.

J Interv Card Electrophysiol 2020 Apr 21. Epub 2020 Apr 21.

Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, 300#, Guangzhou Road, Nanjing, 210029, China.

Purpose: Sinus node inability or conduction disorders of its surrounding atrial myocardium cause sinus node dysfunction (SND). This study aimed to characterize right atrium (RA) substrates and long-term atrial lead performance after pacemaker implantation in non-senile SND patients.

Methods: Eighteen SND patients (53. Read More

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http://dx.doi.org/10.1007/s10840-020-00735-9DOI Listing

Genetic characterization and long-term management of severely affected siblings with intellectual developmental disorder with cardiac arrhythmia syndrome.

Mol Genet Metab Rep 2020 Jun 6;23:100582. Epub 2020 Apr 6.

Departments of Pediatrics and Mattel Children's Hospital at UCLA, Los Angeles, CA, United States of America.

We report two brothers with severe global cognitive and motor delay, cortical visual impairment and sick sinus syndrome who were born to consanguineous parents. Standard genetic evaluations did not reveal the cause of their mental retardation. As expected, chromosomal microarray (CMA) revealed extensive regions of homozygosity. Read More

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http://dx.doi.org/10.1016/j.ymgmr.2020.100582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7138921PMC

Delayed-onset sinus node dysfunction in a child victim of Russell's viper bite.

Asian Cardiovasc Thorac Ann 2020 May 10;28(4):213-215. Epub 2020 Apr 10.

University Paediatrics Unit, Colombo North Teaching Hospital, Ragama, Sri Lanka.

Cardiac complications following envenomation by Russell's viper venom are uncommon. We describe a 14-year-old girl who developed delayed-onset sinus node dysfunction. She presented with mucosal bleeding, ptosis, and muscle weakness. Read More

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http://dx.doi.org/10.1177/0218492320919636DOI Listing

Clinical profile and outcome of familial versus non-familial atrial fibrillation.

Int J Cardiol 2020 Sep 1;314:70-74. Epub 2020 Apr 1.

Cardiac Electrophysiology Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran; Department of Cardiac Electrophysiology, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran. Electronic address:

Background: There is paucity of information on clinical characteristics and outcome of patients with familial atrial fibrillation (AF). The present study was aimed to compare clinical profile and outcome of familial AF with those of non-familial AF.

Methods: Between February 2017 and February 2018, we enrolled 738 participants (60% men, median age, 51 years in familial AF vs. Read More

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http://dx.doi.org/10.1016/j.ijcard.2020.03.080DOI Listing
September 2020
4.036 Impact Factor

Implantable cardiac electronic device therapy for patients with a systemic right ventricle.

Heart 2020 Jul 8;106(14):1052-1058. Epub 2020 Apr 8.

Adult Congenital Heart Centre and National Centre for Pulmonary Hypertension, Royal Brompton Hospital, London, United Kingdom

The systemic right ventricle (SRV), defined as the morphological right ventricle supporting the systemic circulation, is relatively common in congenital heart disease (CHD). Our review aimed at examining the current evidence, knowledge gaps and technical considerations regarding implantable cardiac electronic device therapy in patients with SRV. The risk of sinus node dysfunction (SND) after atrial switch repair and/or complete heart block in congenitally corrected transposition of great arteries requiring permanent pacing increases with age. Read More

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http://dx.doi.org/10.1136/heartjnl-2019-316202DOI Listing

Identification of Functional Variant Enhancers Associated with Atrial Fibrillation.

Circ Res 2020 Apr 6. Epub 2020 Apr 6.

Medical Biology, Amsterdam University Medical Centers.

Genome-wide association studies (GWAS) have identified a large number of common variants (single nucleotide polymorphisms) associated with atrial fibrillation (AF). These variants are located mainly in non-coding regions of the genome and likely include variants that modulate the function of transcriptional regulatory elements (REs) such as enhancers. However, the actual REs modulated by variants as well as the target genes of such REs remain to be identified. Read More

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http://dx.doi.org/10.1161/CIRCRESAHA.119.316006DOI Listing

Short-term and intermediate-term performance and safety of left bundle branch pacing.

J Cardiovasc Electrophysiol 2020 Jun 8;31(6):1472-1481. Epub 2020 Apr 8.

Division of Cardiology, Xiamen Cardiovascular Hospital, Xiamen University, Xiamen, Fujian, China.

Introduction: Left bundle branch pacing (LBBP) is a promising new method for patients with pacing indications. This study aims to evaluate the safety and feasibility of LBBP in a relatively longer time span.

Methods And Results: A total of 164 patients were recruited for LBBP in this study. Read More

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http://dx.doi.org/10.1111/jce.14463DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317583PMC

Effective Pacing Intervention by Closed-loop Stimulation Using a Coronary Vein Lead in a Post-tricuspid Valve Replacement Patient.

Intern Med 2020 1;59(7):963-966. Epub 2020 Apr 1.

Division of Cardiology, Department of Medicine, Nihon University School of Medicine, Japan.

To avoid the negative effects associated with pacing, pacemakers are designed to achieve a pacing cadence as close to physiological pacing as possible. In closed-loop stimulation (CLS; a type of rate-responsive functionality used in pacemakers), the changes in impedance (which correlates with the contractility of the myocardium around the lead tip electrode) are tracked, and the paced heart rate is adjusted accordingly. We herein report a case in which we implanted a pacemaker in a post-tricuspid valve replacement patient. Read More

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http://dx.doi.org/10.2169/internalmedicine.4018-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7184078PMC

Molecular Signatures of Sinus Node Dysfunction Induce Structural Remodeling in the Right Atrial Tissue.

Mol Cells 2020 Apr;43(4):408-418

Department of Biomedical Sciences, College of Medicine, Korea University, Seoul 02841, Korea.

The sinus node (SN) is located at the apex of the cardiac conduction system, and SN dysfunction (SND)-characterized by electrical remodeling-is generally attributed to idiopathic fibrosis or ischemic injuries in the SN. SND is associated with increased risk of cardiovascular disorders, including syncope, heart failure, and atrial arrhythmias, particularly atrial fibrillation. One of the histological SND hallmarks is degenerative atrial remodeling that is associated with conduction abnormalities and increased right atrial refractoriness. Read More

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http://dx.doi.org/10.14348/molcells.2020.2164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191046PMC

Permanent pacemaker implantation in pediatric heart transplant recipients: A systematic review and evidence quality assessment.

Pediatr Transplant 2020 May 18;24(3):e13698. Epub 2020 Mar 18.

Department of Pediatric Cardiac Surgery, Mitera Children's Hospital, HYGEIA Group, Athens, Greece.

Bradyarrhythmias are a common complication following pediatric OHT and may require permanent pacemaker implantation (PPM). The purpose of this study was to investigate the incidence, predictors, and outcomes of children undergoing PPM implantation following OHT. A PRISMA-compliant systematic literature review was performed using the PubMed database and the Cochrane Library (end-of-search date: January 27, 2019). Read More

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http://dx.doi.org/10.1111/petr.13698DOI Listing
May 2020
1.630 Impact Factor

Permanent pacemaker implantation after cardiac surgery: Optimization of the decision making process.

J Thorac Cardiovasc Surg 2020 Feb 19. Epub 2020 Feb 19.

Department of Cardiac Surgery, Upper-Silesian Heart Center, Katowice, Poland; Department of Cardiac Surgery, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland. Electronic address:

Background: Conduction disturbances necessitating permanent pacemaker (PPM) implantation after cardiac surgery occur in 1% to 5% of patients. Previous studies have reported a low rate of late PPM dependency, but there is lack of evidence that it might be related to implantation timing. In this study, we sought to determine whether PPM implantation timing and specific conduction disturbances as indications for PPM implantation are associated with late pacemaker dependency and recovery of atrioventricular (AV) conduction. Read More

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http://dx.doi.org/10.1016/j.jtcvs.2020.01.082DOI Listing
February 2020
4.168 Impact Factor

Clinical course of sinus node dysfunction after thoracoscopic surgery for atrial fibrillation-analysis of the Atrial Fibrillation Ablation and Autonomic Modulation via Thoracoscopic Surgery (AFACT) study.

J Interv Card Electrophysiol 2020 Mar 14. Epub 2020 Mar 14.

Department of Cardiology, Heart Center, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

Purpose: Sinus node dysfunction (SND) may complicate thoracoscopic surgical atrial fibrillation (AF) ablation. Identifying patients at risk is important, as SND may require temporary or permanent pacing. To determine the incidence of postoperative SND and duration of symptoms in patients who underwent thoracoscopic surgical ablation. Read More

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http://dx.doi.org/10.1007/s10840-020-00722-0DOI Listing

Catheter Ablation is Effective for Recovery from Sinus Node Dysfunction in Patients with Atrial Fibrillation, But Close Monitoring is Still Needed.

Authors:
Seung Jung Park

Korean Circ J 2020 Apr;50(4):358-360

Division of Cardiology, Department of Internal Medicine, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

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http://dx.doi.org/10.4070/kcj.2020.0033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067611PMC

First Case of Invasive Stachybotrys Sinusitis.

Clin Infect Dis 2020 Mar 10. Epub 2020 Mar 10.

Department of Molecular Imaging and Therapy, Diabetes and Metabolism Research Institute, Beckman Research Institute, Duarte, California, USA.

Background: The toxigenic mold Stachybotrys has controversially been linked to idiopathic pulmonary hemorrhage and "sick building syndrome". However, there are no previous clinical records of invasive stachybotryosis.

Methods: Sinus biopsy specimens from a 23-year old male with refractory acute lymphocytic leukemia were obtained at three different time points during the patient's hospitalization (139 days) and examined by histopathology and immunohistochemistry (IHC). Read More

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http://dx.doi.org/10.1093/cid/ciaa231DOI Listing

[ECG pearl: sick sinus syndrome mimicking acute coronary syndrome - the aVR-sign].

Orv Hetil 2020 Mar;161(11):434-436

Kardiológiai Osztály, Budai Irgalmasrendi Kórház Budapest, Árpád fejedelem u. 7., 1027.

The aVR-sign can indicate left main or multivessel coronary disease, but the sign is not STEMI eqvivalent and is not a sensitive sign for coronary disese. The following case is an example of this. An 89-year-old woman was admitted with chest pain, atrial fibrillation and multiple lead ST-segment depression but ST-segment elevation in lead aVR. Read More

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http://dx.doi.org/10.1556/650.2020.31681DOI Listing

Closed-loop stimulation as a physiological rate-modulated pacing approach based on intracardiac impedance to lower the atrial tachyarrhythmia burden in patients with sinus node dysfunction and atrial fibrillation.

J Cardiovasc Electrophysiol 2020 May 9;31(5):1187-1194. Epub 2020 Mar 9.

Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Fukuoka, Japan.

Introduction: The effectiveness of rate-modulated pacing for the suppression of atrial fibrillation (AF) is controversial. Closed-loop stimulation (CLS) is a heart rate modulation technique based on the contractility of the right ventricle estimated by sensing myocardial impedance, and CLS can still adapt to the heart rate in conditions where there are no significant changes in acceleration or ventilation, such as emotional stress. We elucidated the association between CLS and atrial tachyarrhythmia (AT) burden in patients with sinus node dysfunction and paroxysmal AF history before pacemaker implantation. Read More

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http://dx.doi.org/10.1111/jce.14430DOI Listing

Incidence of permanent pacemaker implantation after valve replacement surgery : Cardiac structure and function at 1-year follow-up.

Herz 2020 Mar 2. Epub 2020 Mar 2.

Department of Cardiology, Beijing Anzhen Hospital, Beijing Institute of Heart, Lung& Blood Vessel Diseases, Capital Medical University, Beijing, China.

Background: Our study aimed to explore the incidence and risk factors of permanent pacemaker implantation (PPI) after valve replacement surgery (VR). The influence of long-term pacemaker dependency on cardiac structure and function at the 1‑year follow-up was also assessed.

Methods: The demographic and surgical data of all consecutive patients who underwent VR between 2013 and 2016 were collected. Read More

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http://dx.doi.org/10.1007/s00059-020-04895-2DOI Listing

Ventricular fibrillation associated with vasospastic angina pectoris in Fabry disease: a case report.

Eur Heart J Case Rep 2019 Dec 21;3(4):1-5. Epub 2019 Oct 21.

Department of Cardiology, Nagahama Red Cross Hospital, 14-7, Miyamae-cho, Nagahama-shi, Shiga 526-0053, Japan.

Background: Fabry disease (FD) is an X-linked lysosomal storage disorder resulting from a deficiency in alpha-galactosidase A. The major causes of death due to cardiac complications include life-threatening arrhythmias. In addition, life-threatening arrhythmias may be related to myocardial fibrosis assessed by late gadolinium enhancement (LGE). Read More

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http://dx.doi.org/10.1093/ehjcr/ytz192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7042139PMC
December 2019

Molecular and tissue mechanisms of catecholaminergic polymorphic ventricular tachycardia.

J Physiol 2020 Mar 2. Epub 2020 Mar 2.

Vanderbilt Center for Arrhythmia Research and Therapeutics, Division of Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a stress-induced cardiac channelopathy that has a high mortality in untreated patients. Our understanding has grown tremendously since CPVT was first described as a clinical syndrome in 1995. It is now established that the deadly arrhythmias are caused by unregulated 'pathological' calcium release from the sarcoplasmic reticulum (SR), the major calcium storage organelle in striated muscle. Read More

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http://dx.doi.org/10.1113/JP276757DOI Listing