4,823 results match your criteria Sinus Node Dysfunction


Familial Sinus Node Disease Caused by a Gain of GIRK (G-Protein Activated Inwardly Rectifying K Channel) Channel Function.

Circ Genom Precis Med 2019 Jan;12(1):e002238

Department of Cardiovascular Medicine, Institute for Genetics of Heart Diseases (IfGH), University Hospital Münster, Germany (J.K., B.S., S.Z., G.S., E.S.-B.).

Background: Inherited forms of sinus node dysfunction (SND) clinically include bradycardia, sinus arrest, and chronotropic incompetence and may serve as disease models to understand sinus node physiology and impulse generation. Recently, a gain-of-function mutation in the G-protein gene GNB2 led to enhanced activation of the GIRK (G-protein activated inwardly rectifying K channel). Thus, human cardiac GIRK channels are important for heart rate regulation and subsequently, genes encoding their subunits Kir3. Read More

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https://www.ahajournals.org/doi/10.1161/CIRCGEN.118.002238
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http://dx.doi.org/10.1161/CIRCGEN.118.002238DOI Listing
January 2019
4 Reads

Pacemaker programming in patients with first-degree AV-block: Programming pattern and possible consequences.

Health Sci Rep 2018 Jun 9;1(6):e39. Epub 2018 May 9.

Clinical Cardiac Electrophysiology Duke University Medical Center Durham NC USA.

Background: The optimal way of pacing in patients with an indication for pacing and concomitant first-degree atrioventricular (AV)-block is not known, and consequently, firm guidelines on this topic are lacking. This study explored the current pacemaker programming pattern in patients with first-degree AV-block who have a dual chamber pacemaker without cardiac resynchronization.

Methods: The study was a retrospective chart review conducted at Duke University Hospital. Read More

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http://dx.doi.org/10.1002/hsr2.39DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266422PMC

Cellular Mechanisms of Sinus Node Dysfunction in Carriers of the -E161K Mutation and Role of the H558R Polymorphism.

Authors:
Ronald Wilders

Front Physiol 2018 18;9:1795. Epub 2018 Dec 18.

Department of Medical Biology, Amsterdam University Medical Centers, Amsterdam, Netherlands.

Carriers of the E161K mutation in the gene, encoding the Na1.5 pore-forming α-subunit of the ion channel carrying the fast sodium current (I), show sinus bradycardia and occasional exit block. Voltage clamp experiments in mammalian expression systems revealed a mutation-induced 2. Read More

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https://www.frontiersin.org/article/10.3389/fphys.2018.01795
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http://dx.doi.org/10.3389/fphys.2018.01795DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305593PMC
December 2018
3 Reads

Identification of a novel exon3 deletion of RYR2 in a family with catecholaminergic polymorphic ventricular tachycardia.

Ann Noninvasive Electrocardiol 2019 Jan 7:e12623. Epub 2019 Jan 7.

Department of Cardiovascular Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan.

Background: RYR2, encoding cardiac ryanodine receptor, is the major responsible gene for catecholaminergic polymorphic ventricular tachycardia (CPVT). Meanwhile, KCNJ2, encoding inward-rectifier potassium channel (I ), can be the responsible gene for atypical CPVT. We recently encountered a family with CPVT and sought to identify a responsible gene variant. Read More

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http://dx.doi.org/10.1111/anec.12623DOI Listing
January 2019

Two methods for modeling of sick sinus syndrome in rats: Ischemia reperfusion and sodium hydroxide induced injury.

Biomed Pharmacother 2019 Jan 3;111:778-784. Epub 2019 Jan 3.

China Academy of Chinese Medicine Sciences, Xiyuan hospital, 100091, China. Electronic address:

The Sick Sinus Syndrome (SSS) is a serious life-threatening heart disease. It is important to establish a credible and stable sinus node damage model. In this study, we use two methods to construct an SSS damage model in rats. Read More

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http://dx.doi.org/10.1016/j.biopha.2018.11.091DOI Listing
January 2019

Occurrence of significant long PR intervals in patients implanted for sinus node dysfunction and monitored with SafeR™: The PRECISE study.

Arch Cardiovasc Dis 2018 Dec 26. Epub 2018 Dec 26.

Henri Mondor hospital, 94101 Créteil, France.

Background: Long PR intervals may increase cardiovascular complications, including atrial fibrillation. In pacemakers, the SafeR™ mode monitors PR intervals, switching from AAI to DDD when criteria for atrioventricular block are met.

Aims: The PRECISE study evaluated the incidence and predictors of long PR intervals and their association with incident atrial fibrillation after 1 year in patients implanted for sinus node dysfunction and free from significant conduction disorders at baseline. Read More

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http://dx.doi.org/10.1016/j.acvd.2018.09.005DOI Listing
December 2018
1 Read

Development of a Rat Model of Sick Sinus Syndrome Using Pinpoint Press Permeation.

Biomed Res Int 2018 18;2018:7487324. Epub 2018 Nov 18.

Fujian Hypertension Research Institute, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.

Objective: Sick sinus syndrome (SSS) is one of the most common causes of cardiac impairment necessitating pacemaker implantation. However, studies of SSS pathogenesis are neither comprehensive nor conclusive due to limited success in achieving a stable rat SSS model. Here, we modified pinpoint press permeation to establish a stable rat SSS model. Read More

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http://dx.doi.org/10.1155/2018/7487324DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276488PMC
November 2018
1 Read

Selective Use of Temporary Epicardial Pacing Leads in Early Infancy Following Cardiac Surgery: Feasibility and Determinants of Clinical Application.

Pediatr Cardiol 2018 Dec 18. Epub 2018 Dec 18.

Department of Surgery, Medical College of Georgia, Augusta, GA, USA.

Use of temporary epicardial pacing (TEP) leads remains a routine perioperative strategy in congenital heart surgery. Selective use of TEP in neonates and infants undergoing cardiac intervention within the first 6 months of life has, yet, to be assessed. Outcome analysis was undertaken. Read More

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http://dx.doi.org/10.1007/s00246-018-2037-yDOI Listing
December 2018

Pulmonary veins isolation to retard pacemaker implantation.

Clin Case Rep 2018 Dec 30;6(12):2445-2450. Epub 2018 Oct 30.

Cardiology Centre Hospitalier Universitaire Dinant/Godinne Yvoir Belgium.

Sick sinus syndrome is uncommon in children, and syndromic forms are rare. Some forms of sick sinus syndrome like the bradycardia-tachycardia type could be managed by a radiofrequency ablation, even in young children, and could be helpful to delay the implantation of a pacemaker. Read More

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http://dx.doi.org/10.1002/ccr3.1865DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293180PMC
December 2018
1 Read

Canine and human sinoatrial node: differences and similarities in the structure, function, molecular profiles, and arrhythmia.

J Vet Cardiol 2018 Dec 14. Epub 2018 Dec 14.

Department of Physiology and Cell Biology, Dorothy M. Davis Heart & Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH, USA. Electronic address:

The sinoatrial node (SAN) is the primary pacemaker in canine and human hearts. The SAN in both species has a unique three-dimensional heterogeneous structure characterized by small pacemaker myocytes enmeshed within fibrotic strands, which partially insulate the cells from aberrant atrial activation. The SAN pacemaker tissue expresses a unique signature of proteins and receptors that mediate SAN automaticity, ion channel currents, and cell-to-cell communication, which are predominantly similar in both species. Read More

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http://dx.doi.org/10.1016/j.jvc.2018.10.004DOI Listing
December 2018
1 Read

Persistence of a pacemaker lead-like "ghost" 6 months after lead extraction.

Echocardiography 2019 01 9;36(1):201-203. Epub 2018 Dec 9.

Rajaie Cardiovascular Medical & Research Center, Tehran, Iran.

Residual fibrous structures, referred as "ghosts", are occasionally encountered following lead extraction. Though typically detected in patients with cardiac device infections, their prognostic and therapeutic implications remain speculative. We describe a 62-year-old gentleman with history of sick sinus syndrome who presented atrial fibrillation with rapid ventricular response. Read More

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http://dx.doi.org/10.1111/echo.14224DOI Listing
January 2019
1 Read

Atrial fibrillation occurring during head-up tilt testing: Once detected, atrial fibrillation should be monitored, regardless of how it is detected.

Heart Rhythm 2018 Dec 5. Epub 2018 Dec 5.

Division of Cardiology, Department of Internal Medicine, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

Background: Atrial fibrillation (AF) often progresses to more sustained forms and increases the risk of ischemic stroke or sinus node dysfunction. However, there have been no data on the clinical outcomes of patients who developed AF during head-up tilt testing (HUT).

Objective: The purpose of this study was to evaluate the clinical significance of AF detected during HUT performed for syncope evaluation. Read More

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http://dx.doi.org/10.1016/j.hrthm.2018.11.030DOI Listing
December 2018
3 Reads
5.076 Impact Factor

An Itchy Lead: First Reported Case of Ventricular Pacemaker Lead Self-Extraction.

J Atr Fibrillation 2018 Aug 31;11(2):2052. Epub 2018 Aug 31.

Division of Cardiology, Altru Health System, Grand Forks, North Dakota 58201.

We present a particularly rare case and the first ever report of a ventricular self-extraction in a 98-year old female. Our patient had a past medical history significant for severe Alzheimer's dementia, paroxysmal atrial fibrillation, and sick sinus syndrome who was admitted in clinically stable condition following the unwitnessed self-extraction the ventricular lead of her dual chamber pacemaker. This case highlights the potential risks and other clinical challenges of pacemaker and ICD placement in elderly patients and in patients with cognitive impairment. Read More

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http://dx.doi.org/10.4022/jafib.2052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244303PMC
August 2018
1 Read

The first successful implantation of an intravenous AAIR pacemaker into autologous extracardiac lateral tunnel Fontan in the child.

J Electrocardiol 2018 Nov - Dec;51(6):1015-1018. Epub 2018 Jul 27.

Department of Cardiology, Congenital Heart Diseases and Electrotherapy, Silesian Center for Heart Diseases, Zabrze, Poland; Department of Dietetics, School of Public Health in Bytom, Medical University of Silesia, Katowice, Poland.

Patients with a single ventricle have complex anatomy that requires staged palliation which is usually the Fontan procedure. This procedure has undergone a lot of modifications to improve hemodynamics. Despite these efforts, sinus node dysfunction (SND) and bradyarrythmias are still common complications after Fontan operation, therefore there is a need of pacemakers implantation. Read More

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http://dx.doi.org/10.1016/j.jelectrocard.2018.07.019DOI Listing
July 2018
1 Read

Dysrhythmias in patients with a complete atrioventricular septal defect: From surgery to early adulthood.

Congenit Heart Dis 2018 Nov 28. Epub 2018 Nov 28.

Department of Cardiothoracic Surgery, Erasmus University Medical Center, Rotterdam, The Netherlands.

Objective: Outcomes after surgical repair of complete atrioventricular septal defect (cAVSD) have improved. With advancing age, the risk of development of dysrhythmias may increase. The aims of this study were to (1) examine development of sinus node dysfunction (SND), atrial and ventricular tachyarrhythmias, and (2) study progression of atrioventricular conduction abnormalities in young adult patients with repaired cAVSD. Read More

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http://dx.doi.org/10.1111/chd.12724DOI Listing
November 2018
1 Read

Cyclical sinus bradycardia and atrioventricular block induced by ticagrelor.

HeartRhythm Case Rep 2018 Nov 8;4(11):527-529. Epub 2018 Aug 8.

Department of Cardiology, Montreal Heart Institute, Université de Montréal, Montreal, Canada.

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http://dx.doi.org/10.1016/j.hrcr.2018.07.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6241168PMC
November 2018
1 Read

Three-Dimensional Printing Technology Combined With Postmortem Computed Tomography Angiography as New Form of Forensic Evidence: A Case Report.

Am J Forensic Med Pathol 2018 Nov 20. Epub 2018 Nov 20.

Shanghai Key Laboratory of Forensic Medicine, Academy of Forensic Science, Shanghai, China.

Postmortem computed tomography (PMCT) and PMCT angiography are increasingly used in forensic practice. However, their application in court is still limited because they need professional equipment or software to be displayed. In this article, the authors introduce 3-dimensional (3D) printing technology as a new approach to provide evidence in court. Read More

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http://dx.doi.org/10.1097/PAF.0000000000000443DOI Listing
November 2018
2 Reads

Surgical repair of partial anomalous pulmonary venous return with intact atrial septum in a 65-year-old woman: a case report.

J Med Case Rep 2018 Nov 24;12(1):350. Epub 2018 Nov 24.

Department of General and Cardiothoracic Surgery, Graduate School of Medicine, Gifu University, 1-1 Yanagido, Gifu City, 501-1194, Japan.

Background: Partial anomalous pulmonary venous return is a rare congenital cardiac anomaly that usually involves the right pulmonary vein and an atrial septal defect. Isolated partial anomalous pulmonary venous return with an intact atrial septum is even rarer, and this condition is usually treated surgically in younger patients. We describe isolated partial anomalous pulmonary venous return in a 65-year-old woman who was treated by caval division with pericardial patch baffling through a surgically created atrial septal defect and reconstruction of the superior vena cava using a prosthetic graft. Read More

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http://dx.doi.org/10.1186/s13256-018-1874-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260651PMC
November 2018
8 Reads

Sick Sinus Syndrome Observed in a Patient with Cholinesterase Deficiency.

Intern Med 2018 Nov 19. Epub 2018 Nov 19.

Heart Center, Kyushu University Hospital, Japan.

A 58-year-old woman complained of general fatigue and was diagnosed with sick sinus syndrome (SSS) by ambulatory electrocardiogram, which demonstrated sinus arrest at midnight and paroxysmal atrial fibrillation (AF) at nighttime. Since her plasma cholinesterase (ChE) activity had been persistently zero, she was diagnosed with ChE deficiency. She refused permanent pacemaker implantation, and treatment with positive chronotropic drugs is ongoing. Read More

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https://www.jstage.jst.go.jp/article/internalmedicine/advpub
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http://dx.doi.org/10.2169/internalmedicine.1229-18DOI Listing
November 2018
6 Reads

Pleiotropic effects of schizophrenia-associated genetic variants in neuron firing and cardiac pacemaking revealed by computational modeling.

Transl Psychiatry 2017 11 17;7(11). Epub 2017 Nov 17.

NORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.

Schizophrenia patients have an increased risk of cardiac dysfunction. A possible factor underlying this comorbidity are the common variants in the large set of genes that have recently been discovered in genome-wide association studies (GWASs) as risk genes of schizophrenia. Many of these genes control the cell electrogenesis and calcium homeostasis. Read More

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http://dx.doi.org/10.1038/s41398-017-0007-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802468PMC
November 2017

Clinical characteristics and outcome of lone atrial fibrillation at a tertiary referral centre: the Groote Schuur Hospital experience.

Cardiovasc J Afr 2018 Sep/Oct;29(5):268-272

The Cardiac Clinic, Department of Medicine, Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa.

Introduction: Atrial fibrillation (AF) is a relatively common arrhythmia. When AF represents an electrophysiological phenomenon in structurally normal hearts, it is termed lone AF. This study was a retrospective, case-based analysis of patients attending the Cardiac Clinic at Groote Schuur Hospital (GSH) and describes the clinical characteristics and outcomes of patients classified as having lone atrial fibrillation. Read More

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http://cvja.co.za/onlinejournal/vol29/vol29_issue5/#6/z
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http://dx.doi.org/10.5830/CVJA-2018-005DOI Listing
May 2017
4 Reads

Evaluation of a near-zero fluoroscopic approach for catheter ablation in patients with congenital heart disease.

J Interv Card Electrophysiol 2018 Oct 30. Epub 2018 Oct 30.

Electrophysiology Section, Cardiology Department, Hospital Universitari i Politècnic La Fe, Área de Enfermedades Cardiovasculares, Planta 4-Torre F, Av. Fernando Abril Martorell, 106, 46026, Valencia, Spain.

Purpose: Radiation exposure (RE) is a matter of concern for patients with congenital heart disease (CHD) who not infrequently need multiple interventional procedures under fluoroscopy guidance. We sought to evaluate the safety and feasibility of a minimally fluoroscopic approach in patients with CHD undergoing catheter ablation using a new image integration module (IIM).

Methods: Consecutive patients with CHD undergoing catheter ablation using the Carto Univu™ IIM were included. Read More

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http://dx.doi.org/10.1007/s10840-018-0467-3DOI Listing
October 2018
1 Read

Role of the monocyte-to-high-density lipoprotein ratio in predicting atrial high-rate episodes detected by cardiac implantable electronic devices.

Authors:
Seckin Satilmis

North Clin Istanb 2018 12;5(2):96-101. Epub 2018 Apr 12.

Department of Cardiology, Acibadem Atakent University Hospital, Istanbul, Turkey.

Objective: Technological advances have allowed cardiac implantable electronic devices (CIEDs) to detect, analyze, and store atrial high-rate episodes (AHREs), which are surrogate for the term silent atrial fibrillation (AF). The association of AHREs with adverse clinical events has been demonstrated in several recent studies, implying that morbidity and mortality can be significantly prevented by prompt recognition and intervention. Inflammation and oxidative stress are among several mechanisms that contribute to the pathogenesis of AF. Read More

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http://www.kuzeyklinikleri.com/jvi.aspx?pdir=nci&plng=tu
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http://dx.doi.org/10.14744/nci.2017.35761DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191558PMC
April 2018
6 Reads

Sick Sinus Syndrome After the Maze Procedure Performed Concomitantly With Mitral Valve Surgery.

J Am Heart Assoc 2018 Oct;7(19):e009629

1 Division of Cardiology Asan Medical Center University of Ulsan College of Medicine Seoul Korea.

Background To characterize the development of sick sinus syndrome ( SSS ) after the additive maze procedure ( MP ) during mitral valve surgery. Methods and Results Follow-up data (median, 3.6 years) of 750 patients with a prevalence of rheumatic cause of 57. Read More

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https://www.ahajournals.org/doi/10.1161/JAHA.118.009629
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http://dx.doi.org/10.1161/JAHA.118.009629DOI Listing
October 2018
6 Reads

Sex-Dependent Phenotypic Variability of an SCN5A Mutation: Brugada Syndrome and Sick Sinus Syndrome.

J Am Heart Assoc 2018 Sep;7(18):e009387

1 Keio University Hospital Tokyo Japan.

Background Brugada syndrome ( BS ) is known to be 9 times more prevalent in males than females. However, little is known about the development of sick sinus syndrome in female members with familial BS . Methods and Results Familial BS patients and family members, both from our institutions and collaborating sites that specialize in clinical care of BS , participated in this study. Read More

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http://dx.doi.org/10.1161/JAHA.118.009387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222934PMC
September 2018
3 Reads

A New Cardiac Channelopathy: From Clinical Phenotypes to Molecular Mechanisms Associated With Na1.5 Gating Pores.

Front Cardiovasc Med 2018 9;5:139. Epub 2018 Oct 9.

CERVO Research Centre, Institut Universitaire en Santé Mentale de Québec, Quebec City, QC, Canada.

Voltage gated sodium channels (Na) are broadly expressed in the human body. They are responsible for the initiation of action potentials in excitable cells. They also underlie several physiological processes such as cognitive, sensitive, motor, and cardiac functions. Read More

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https://www.frontiersin.org/article/10.3389/fcvm.2018.00139/
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http://dx.doi.org/10.3389/fcvm.2018.00139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6189448PMC
October 2018
8 Reads

Unifocal Right-Sided Ablation Treatment for Neurally Mediated Syncope and Functional Sinus Node Dysfunction Under Computed Tomographic Guidance.

Circ Arrhythm Electrophysiol 2018 Sep;11(9):e006604

The Lambe Institute for Translational Medicine and Curam, National University of Ireland, Galway and Saolta University Healthcare Group (W.W.).

Background Biatrial, extensive, and complex ablation strategies have been published for the treatment of neurally mediated syncope, sinus node dysfunction, and functional atrioventricular block. We have developed a less extensive and more specific approach compared with previously published cardioneuroablation strategies, called cardio-neuromodulation. It is based on tailored vagolysis of the sinoatrial node through partial ablation of the anterior right-ganglionated plexus, preferentially through a right-sided approach. Read More

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https://www.ahajournals.org/doi/10.1161/CIRCEP.118.006604
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http://dx.doi.org/10.1161/CIRCEP.118.006604DOI Listing
September 2018
7 Reads

Dysphagia unveiling systemic immunoglobulin light-chain amyloidosis with multiple myeloma.

BMJ Case Rep 2018 Oct 21;2018. Epub 2018 Oct 21.

Internal Medicine, McLaren Health Care Corp, Flint, Michigan, USA.

Dysphagia is an uncommon presentation of systemic immunoglobulin light-chain (AL) amyloidosis with multiple myeloma (MM). Gastrointestinal (GI) involvement usually manifests with altered motility, malabsorption or bleeding. Furthermore, patients identified with GI amyloidosis, without previous diagnosis of a plasma cell disorder, are extremely rare. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22633
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http://dx.doi.org/10.1136/bcr-2018-226331DOI Listing
October 2018
7 Reads

Azygos Vein to the Rescue of Warden Anastomosis in High Pulmonary Venous Drainage.

World J Pediatr Congenit Heart Surg 2018 Oct 18:2150135118769319. Epub 2018 Oct 18.

1 Department of Cardiothoracic and Vascular Surgery, Sri Sathya Sai Institute of Higher Medical Sciences, Whitefield, Bangalore, India.

Partial anomalous pulmonary venous return is a congenital anomaly in which some of the pulmonary veins drain into the right atrium or one of its venous tributaries. Although excellent long-term results have been described for the classic two-patch technique repair in older patients, The Warden procedure has an important role in smaller and younger patients and those patients in whom the superior vena cava (SVC) may be small and the right-sided pulmonary veins may connect high, at or above the azygos vein. In addition to prevention of early and late sinus node dysfunction, the Warden procedure helps to avoid systemic or pulmonary venous obstruction if care is taken to ensure a tension-free Warden anastomosis. Read More

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http://dx.doi.org/10.1177/2150135118769319DOI Listing
October 2018
1 Read

Safety and efficacy of AAIR pacing in selected patients with sick sinus syndrome.

Medicine (Baltimore) 2018 Oct;97(42):e12833

Division of Cardiology, Grey Nuns Community Hospital, Edmonton, Alberta, Canada.

Background: The DANPACE study suggested implanting dual-pacing dual-sensing dual-response rate-adaptive (DDDR) pacemakers in patients with sick sinus syndrome, even though 90.7% of their atrial-pacing atrial-sensing inhibited-response rate-adaptive (AAIR) group did not require upgrade. Most centers implant DDDR pacemakers due to risk of future atrioventricular (AV) block. Read More

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http://dx.doi.org/10.1097/MD.0000000000012833DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211929PMC
October 2018
2 Reads

The limitations and potential adverse effects of the premature ventricular contraction response.

J Arrhythm 2018 Oct 22;34(5):572-575. Epub 2018 Jun 22.

Division of Cardiovascular Medicine Department of Internal Medicine Kobe University Graduate School of Medicine Kobe Japan.

A 69-year-old man, who had undergone surgery for mitral and tricuspid regurgitation with the Maze procedure for paroxysmal atrial fibrillation, was admitted with an episode of syncope due to sick sinus syndrome. Three days after implantation of a dual-chamber pacemaker (Accent MRI™, St. Jude Medical Inc. Read More

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http://dx.doi.org/10.1002/joa3.12082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6174512PMC
October 2018
1 Read

Improving the utilization of implantable cardioverter defibrillators for sudden cardiac arrest prevention (Improve SCA) in developing countries: Clinical characteristics and reasons for implantation refusal.

Pacing Clin Electrophysiol 2018 Dec 31;41(12):1619-1626. Epub 2018 Oct 31.

Department of Cardiac Rhythm Management, Medtronic, Mounds View, Minnesota.

Background: Despite available evidence that implantable cardioverter defibrillators (ICDs) reduce all-cause mortality among patients at risk for sudden cardiac death, utilization of ICDs is low especially in developing countries.

Objective: To summarize reasons for ICD or cardiac resynchronization therapy defibrillator implant refusal by patients at risk for sudden cardiac arrest (Improve SCA) in developing countries.

Methods: Primary prevention (PP) and secondary prevention (SP) patients from countries where ICD use is low were enrolled. Read More

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http://doi.wiley.com/10.1111/pace.13526
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http://dx.doi.org/10.1111/pace.13526DOI Listing
December 2018
3 Reads

Tbx18 sets the pace.

J Physiol 2018 Dec 2;596(24):6129-6130. Epub 2018 Nov 2.

University of Chicago, Pathology, 5841 S. Maryland Avenue, Chicago, IL, USA.

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http://dx.doi.org/10.1113/JP277180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292809PMC
December 2018
3 Reads

Takotsubo syndrome with severe bradycardia initiated by seizure: Is the implantation of a permanent pacemaker necessary?

BMJ Case Rep 2018 Oct 12;2018. Epub 2018 Oct 12.

Department of Cardiovascular Medicine, Nippon Medical School, Bunkyo-ku, Tokyo, Japan.

Although arrhythmias are frequent in patients with Takotsubo syndrome (TTS), data on sick sinus syndrome remain elusive. Here, we report a case of TTS initiated by a seizure as a physical trigger that led to sinus arrest. The patient presented with cardiogenic shock and bradycardia which required intensive cardiovascular care. Read More

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http://dx.doi.org/10.1136/bcr-2018-226480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6194446PMC
October 2018
1 Read

Extracardiac Versus lateral tunnel Fontan: A Meta-Analysis of Long-Term Results.

Ann Thorac Surg 2018 Oct 10. Epub 2018 Oct 10.

Division of cardiac surgery, CHU-ME Sainte Justine and the Montreal Heart Institute, Université de Montréal, Montréal, Canada. Electronic address:

Background: There is growing awareness of the long-term impact of a Fontan circulation on the associated morbidity and mortality. Comparative data on the incidence of supraventricular arrhythmia and sinus node dysfunction following extra cardiac (EC) and lateral tunnel (LT) Fontans are controversial. We performed a meta-analysis pooling all available long-term results comparing the EC and LT Fontan with a special focus on arrhythmia. Read More

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http://dx.doi.org/10.1016/j.athoracsur.2018.08.041DOI Listing
October 2018

Home Monitoring for Fetal Heart Rhythm During Anti-Ro Pregnancies.

J Am Coll Cardiol 2018 Oct;72(16):1940-1951

Division of Cardiology, Department of Pediatrics, Hospital for Sick Children, Toronto, Canada.

Background: Fetal atrioventricular block (AVB) occurs in 2% to 4% of anti-Ro antibody-positive pregnancies and can develop in <24 h. Only rarely has standard fetal heart rate surveillance detected AVB in time for effective treatment.

Objectives: Outcome of anti-Ro pregnancies was surveilled with twice-daily home fetal heart rate and rhythm monitoring (FHRM) and surveillance echocardiography. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07351097183694
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http://dx.doi.org/10.1016/j.jacc.2018.07.076DOI Listing
October 2018
18 Reads

Arrhythmias and conduction disorders associated with atrial septal defects.

J Thorac Dis 2018 Sep;10(Suppl 24):S2940-S2944

Division of Cardiology, Department of Pediatrics, Rady Children's Hospital San Diego, University of California San Diego, San Diego, CA 92123, USA.

Atrial septal defects (ASDs) are the most common form of congenital heart disease. There are 4 embryologic types of ASDs, and rhythm considerations vary based on type. ASDs have left-to-right shunt and primarily right-sided volume overload. Read More

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http://jtd.amegroups.com/article/view/23665/18016
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http://dx.doi.org/10.21037/jtd.2018.08.27DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6174150PMC
September 2018
3 Reads

Prevalence and predictors of atrial arrhythmias in patients with sinus node dysfunction and atrial pacing.

J Interv Card Electrophysiol 2018 Dec 6;53(3):365-371. Epub 2018 Oct 6.

Department of Medicine, Section of Cardiology, Center for Arrhythmia Care, Heart and Vascular Center, University of Chicago Medicine Pritzker School of Medicine, 5841 S. Maryland Avenue, MC 6092, Chicago, IL, 60637, USA.

Purpose: This study aimed to determine the incidence, prevalence, and predictors of atrial arrhythmias (AAs) in patients with symptomatic sinus node dysfunction (SND) who required permanent pacemaker implantation. Also, we evaluated the impact of atrial pacing (AP) on AAs.

Methods: All consecutive patients who underwent pacemaker implantation from 2005 to 2011 were included. Read More

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http://link.springer.com/10.1007/s10840-018-0463-7
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http://dx.doi.org/10.1007/s10840-018-0463-7DOI Listing
December 2018
8 Reads

Mechanistic insights into the interaction of the MOG1 protein with the cardiac sodium channel Na1.5 clarify the molecular basis of Brugada syndrome.

J Biol Chem 2018 Nov 3;293(47):18207-18217. Epub 2018 Oct 3.

From the Key Laboratory of Molecular Biophysics of the Ministry of Education, Cardio-X Center, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan 430074, China,

Na1.5 is the α-subunit of the cardiac sodium channel complex. Abnormal expression of Na1. Read More

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http://dx.doi.org/10.1074/jbc.RA118.003997DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6254340PMC
November 2018
6 Reads

Incorrect Holter-ECG analysis caused by the pacemaker delivering small high-frequency currents for thoracic impedance measurement.

J Cardiol Cases 2017 Dec 12;16(6):219-222. Epub 2017 Sep 12.

Department of Cardiology, Kido General Hospital, Niigata, Japan.

In an 86-year-old woman who had been treated for sick sinus syndrome, the small high-frequency current delivered by pacemaker in order to measure the minutes ventilation for utilizing the rate-response mode was transiently over-sensed on the Holter electrocardiogram. Although her pacing system was working appropriately, the numbers of the paced beats on the automatic Holter analysis were undercounted (from >60% to <5%) during the over-sensing periods because these currents were recognized as multiple pacing spikes. Physicians need to pay attention to such multiple pacing spike markers, because these can be a cause of unreliable results of the Holter analysis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18785409173008
Publisher Site
http://dx.doi.org/10.1016/j.jccase.2017.08.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149630PMC
December 2017
3 Reads

Left Ventricular Aneurysm Presenting as Bidirectional Ventricular Tachycardia.

Ochsner J 2018 ;18(3):288-290

Department of Cardiology, University of Miami/JFK Medical Center, Atlantis, FL.

Background: Bidirectional ventricular tachycardia is a rare form of ventricular arrhythmia, characterized by a changing of the mean QRS axis of 180 degrees. Digitalis toxicity is the most common cause of bidirectional ventricular tachycardia; other causes include myocarditis, aconite toxicity, metastatic cardiac tumor, myocardial infarction, and cardiac channelopathies.

Case Report: A 73-year-old male with hypertension and a pacemaker implanted for sick sinus syndrome presented with a complaint of substernal chest pressure for several days. Read More

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http://dx.doi.org/10.31486/toj.18.0023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162124PMC
January 2018
3 Reads

Chromosome 4q25 Variant rs6817105 Bring Sinus Node Dysfunction and Left Atrial Enlargement.

Sci Rep 2018 Oct 1;8(1):14565. Epub 2018 Oct 1.

Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan.

Genome-wide association studies have reported a strong association of the single nucleotide polymorphism (SNP) rs6817105 (T > C) on chromosome 4q25 with atrial fibrillation (AF), but phenotype alterations conferred by this SNP have not been described. We genotyped SNP rs6817105 and examined the relationships among rs6817105 genotype, clinical characteristics, echocardiographic parameters, and electrophysiological parameters in 574 AF patients and 1,554 non-AF controls. Further, multiple microRNAs (miRNAs) are reported to be involved in atrial remodeling and AF pathogenesis, so we investigated relationships between rs6817105 genotype and serum concentrations of 2555 miRNAs. Read More

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http://www.nature.com/articles/s41598-018-32453-8
Publisher Site
http://dx.doi.org/10.1038/s41598-018-32453-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167315PMC
October 2018
2 Reads

TBX18 overexpression enhances pacemaker function in a rat subsidiary atrial pacemaker model of sick sinus syndrome.

J Physiol 2018 Dec 13;596(24):6141-6155. Epub 2018 Oct 13.

Institute of Cardiovascular Sciences, University of Manchester, Manchester, UK.

Key Points: The sinoatrial node (SAN) is the primary pacemaker of the heart. SAN dysfunction, or 'sick sinus syndrome', can cause excessively slow heart rates and pauses, leading to exercise limitation and syncope, currently treated by implantation of an electronic pacemaker. 'Biopacemaking' utilises gene therapy to restore pacemaker activity by manipulating gene expression. Read More

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http://doi.wiley.com/10.1113/JP276508
Publisher Site
http://dx.doi.org/10.1113/JP276508DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292813PMC
December 2018
14 Reads

[Bachmann bundle pacing].

Herz 2018 Nov;43(7):584-595

Klinik für Innere Medizin - Kardiologie, Diabetologie & Nephrologie, Evangelisches Klinikum Bethel, Burgsteig 13, 33617, Bielefeld, Deutschland.

In pacemaker and ICD therapy, atrial leads are usually implanted in the right atrial appendage (RAA). This is easy but associated with a risk of negative hemodynamic and electrophysiological effects. Atrial depolarization, atrial contraction, and atrioventricular conduction can be delayed and desynchronized by RAA pacing leading to atrial fibrillation, pacing-induced long first-degree AV block, right ventricular pacing and the development of heart failure. Read More

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http://dx.doi.org/10.1007/s00059-018-4755-6DOI Listing
November 2018
10 Reads

Cardiac chronotropic hypo-responsiveness and atrial fibrosis in rats chronically treated with lithium.

Auton Neurosci 2019 Jan 7;216:46-50. Epub 2018 Sep 7.

Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Lithium is a widely used mood-stabilizing agent; however, it causes a variety of cardiovascular side effects including sinus node dysfunction. In this study we explored the potential adverse effects of lithium on cardiac chronotropic responsiveness, atrial tissue histology and gene expression in rats that were chronically treated with therapeutic doses of lithium. Male Wistar albino rats were given lithium chloride (2. Read More

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http://dx.doi.org/10.1016/j.autneu.2018.09.002DOI Listing
January 2019
1 Read

Genetic mutation of familial dilated cardiomyopathy based on next‑generation semiconductor sequencing.

Mol Med Rep 2018 Nov 5;18(5):4271-4280. Epub 2018 Sep 5.

Provincial Clinical Medical College, Fujian Medical University, Fuzhou, Fujian 350001, P.R. China.

Dilated cardiomyopathy (DCM) is a complex myocardial disease of multifactorial etiologies, including enlarged cardiac chambers and contractile dysfunction. It has been suggested that the inheritance of DCM‑associated mutations predominates its onset. Therefore, the present study investigated the pathogenesis of DCM via pedigree analysis and genetic diagnosis by massive whole‑exome screening, and targeted exon capture. Read More

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http://dx.doi.org/10.3892/mmr.2018.9455DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172371PMC
November 2018
3 Reads