4,851 results match your criteria Sinus Node Dysfunction


Cardiac Rhythm Disturbances in Heterotaxy Syndrome.

Pediatr Cardiol 2019 Mar 14. Epub 2019 Mar 14.

Department of Pediatrics, University of Tokyo Hospital, Tokyo, Japan.

Objective: Heterotaxy syndrome is associated with complex cardiac malformations and cardiac conduction system abnormalities. Those with right atrial isomerism (RAI) have dual sinus nodes and dual atrioventricular nodes predisposing them to supraventricular tachycardia (SVT). Those with left atrial isomerism (LAI) lack a normal sinus node and are at risk of sinus node dysfunction (SND) and atrioventricular block (AV block). Read More

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http://dx.doi.org/10.1007/s00246-019-02087-2DOI Listing

A new combination of transcription factors increases the harvesting efficiency of pacemaker‑like cells.

Mol Med Rep 2019 Mar 6. Epub 2019 Mar 6.

Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China.

Biological pacemakers that combine cell‑based and gene‑based therapies are a promising treatment for sick sinus syndrome or severe atrioventricular block. The current study aimed to induce differentiation of adipose tissue‑derived stem cells (ADSCs) into cardiac pacemaker cells through co‑expression of the transcription factors insulin gene enhancer binding protein 1 (ISL‑1) and T‑box18 (Tbx18). ADSCs were transfected with green fluorescent protein, ISL‑1, Tbx18 or ISL‑1+Tbx18 fluorescent protein lentiviral vectors, and subsequently co‑cultured with neonatal rat ventricular cardiomyocytes in vitro for 7 days. Read More

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http://dx.doi.org/10.3892/mmr.2019.10012DOI Listing
March 2019
1.484 Impact Factor

Bradyarrhythmia development and permanent pacemaker implantation after cardiac surgery.

North Clin Istanb 2018 8;5(4):288-294. Epub 2018 Aug 8.

Department of Cardiology, Health Science University Dr. Siyami Ersek Training and Research Hospital, Istanbul, Turkey.

Objective: Bradyarrhythmia is one of the complications that may develop after cardiac surgery. Only a few studies have previously dealt with this concern, and in our study, we investigated the factors affecting the development of atrioventricular block or sinus node dysfunction and the requirement of permanent pacemaker following cardiac surgery.

Methods: A total of 62 patients who developed the atrioventricular (AV) block or sinus node dysfunction and required a permanent pacemaker following cardiac surgery were included in the study. Read More

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http://dx.doi.org/10.14744/nci.2017.20438DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371988PMC

Clinical characteristics and rhythm outcome of catheter ablation of hemodynamically corrected valvular atrial fibrillation.

J Cardiol 2019 Mar 5. Epub 2019 Mar 5.

Yonsei University Health System, Seoul, Republic of Korea. Electronic address:

Background: Although the hemodynamic burden and structural substrate contribute to valvular atrial fibrillation (VAF) mechanisms, the role of catheter ablation has rarely been reported. We investigated the clinical characteristics, mapping findings, and long-term rhythm outcomes after catheter ablation of hemodynamically corrected VAF.

Methods: We compared 77 patients with VAF (46. Read More

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http://dx.doi.org/10.1016/j.jjcc.2018.10.014DOI Listing
March 2019
1 Read

Ser96Ala genetic variant of the human histidine-rich calcium-binding protein is a genetic predictor of recurrence after catheter ablation in patients with paroxysmal atrial fibrillation.

PLoS One 2019 6;14(3):e0213208. Epub 2019 Mar 6.

Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan.

Background: Atrial fibrillation (AF) recurrence after radiofrequency catheter ablation (RFCA) still remains a serious issue. Ca2+ handling has a considerable effect on AF recurrence. The histidine-rich calcium-binding protein (HRC) genetic single nucleotide polymorphism (SNP), rs3745297 (T>G, Ser96Ala), is known to cause a sarcoplasmic reticulum Ca2+ leak. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0213208PLOS
March 2019
2 Reads

Permanent Pacemaker Implantation in Patients With Isolated Persistent Left Superior Vena Cava From a Right-Sided Approach: Technical Considerations and Follow-Up Outcome.

Cardiol Res 2019 Feb 24;10(1):18-23. Epub 2019 Feb 24.

Department of Cardiology, LPS Institute of Cardiology, G.S.V.M. Medical College, Kanpur, Uttar Pradesh, India.

Background: Positioning a permanent pacing wire in patients with persistent left superior vena cava (PLSVC) to right ventricle often comes as on-table surprise. It is technically demanding and therefore most of operators prefer left-sided approach. We assessed technical challenges during pacemaker implantation, and their short- and long-term outcomes among patients with isolated PLSVC from a right-sided approach. Read More

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http://dx.doi.org/10.14740/cr784DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396803PMC
February 2019
1 Read

Leadless pacemaker implantation: A feasible and reasonable option in transcatheter heart valve replacement patients.

Pacing Clin Electrophysiol 2019 Mar 4. Epub 2019 Mar 4.

Division of Cardiology, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, 10032.

Background: Leadless pacemakers (LPMs) have been shown to have lower post- operative complications than traditional permanent pacemakers but there have been no studies on the outcomes of LPMs in patients with transcatheter heart valve replacements (THVRs). This study determined outcomes of LPMs compared to single chamber transvenous pacemakers (SCPs) post-THVR.

Methods: This is a retrospective single-center study including 10 patients who received LPMs post-THVR between February 2017 and August 2018 and a comparison group of 23 patients who received SCP post-THVR between July 2008 and August 2018. Read More

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http://dx.doi.org/10.1111/pace.13648DOI Listing
March 2019
1 Read

Robotic repair of partial anomalous pulmonary venous connection: the initial experience and technical details.

J Robot Surg 2019 Mar 4. Epub 2019 Mar 4.

Department of Anesthesiology and Reanimation, University of Health Sciences, Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, Istanbul, Turkey.

This study reports our initial experience with robotic-assisted partial anomalous pulmonary venous connection (PAPVC) repair. From May 2013 through September 2018, 20 patients (12 male and 8 female) underwent robotic-assisted repair of a right-sided (n = 19) or a left-sided (n = 1) PAPVC. The mean age was 24. Read More

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http://dx.doi.org/10.1007/s11701-019-00943-0DOI Listing
March 2019
1 Read

[The Pacemaker and Implantable Cardioverter-Defibrillator Registry of the Italian Association of Arrhythmology and Cardiac Pacing - Annual report 2017].

G Ital Cardiol (Rome) 2019 Mar;20(3):136-148

Dipartimento di Medicina Ambientale e Salute Pubblica, Università degli Studi, Padova.

Background: The pacemaker (PM) and implantable cardioverter-defibrillator (ICD) Registry of the Italian Association of Arrhythmology and Cardiac Pacing (AIAC) monitors the main epidemiological data in real-world practice. The survey for the 2017 activity collects information about demographics, clinical characteristics, main indications for PM/ICD therapy and device types from the Italian collaborating centers.

Methods: The Registry collects prospectively national PM and ICD implantation activity on the basis of European cards. Read More

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http://dx.doi.org/10.1714/3108.30963DOI Listing
March 2019
6 Reads

Fetal arrhythmias: Diagnosis and management.

Indian Pacing Electrophysiol J 2019 Feb 25. Epub 2019 Feb 25.

Department of Pediatrics, Oregon Health & Science University, Portland, OR, USA.

This article reviews important features for improving the diagnosis and management of fetal arrhythmias. The normal fetal heart rate ranges between 110 and 160 beats per minute. A fetal heart rate is considered abnormal if the heart rate is beyond the normal ranges or the rhythm is irregular. Read More

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http://dx.doi.org/10.1016/j.ipej.2019.02.007DOI Listing
February 2019
1 Read

One stage atrioventricular nodal ablation and leadless pacemaker implantation for refractory atrial fibrillation.

J Arrhythm 2019 Feb 1;35(1):139-141. Epub 2018 Nov 1.

Cardiac Health Heart Centred and Cardiology Division Department of Medicine Queen Mary Hospital The University of Hong Kong Hong Kong China.

Atrioventricular nodal (AVN) ablation and right ventricular (RV) pacing is recommended for refractory atrial fibrillation (AF) and tachycardia-bradycardia syndrome. Three AF patients (mean age 83, range 79-89 years) underwent AVN ablation and transvenous leadless pacemaker Micra implantations using the same venous access without anticoagulation interruption. Satisfactory pacing 0. Read More

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http://dx.doi.org/10.1002/joa3.12129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373659PMC
February 2019
1 Read

Permanent pacemaker implantation after pediatric heart transplantation: Risk factors, indications, and outcomes.

Clin Transplant 2019 Feb 20:e13503. Epub 2019 Feb 20.

Great Ormond Street Hospital for Children Foundation Trust, London, UK.

Background: Permanent pacemaker (PPM) placement in adults following orthotopic heart transplantation (OHT) has been well documented. However, studies concerning the need for PPM implantation in pediatric heart transplant recipients are less common.

Methods: Institutional transplant and pacing databases as well as patient medical records were reviewed for all pediatric patients undergoing OHT (n = 314; all with bicaval connection) at our institution between January 2000 and March 2018. Read More

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http://dx.doi.org/10.1111/ctr.13503DOI Listing
February 2019
2 Reads

Mutant KCNJ3 and KCNJ5 Potassium Channels as Novel Molecular Targets in Bradyarrhythmias and Atrial Fibrillation.

Circulation 2019 Feb 15. Epub 2019 Feb 15.

Department of Medical Biochemistry, Osaka University Graduate School of Medicine, Japan.

Background: Bradyarrhythmia is a common clinical manifestation. Although the majority of cases are acquired, genetic analysis of families with bradyarrhythmia has identified a growing number of causative gene mutations. Since the only ultimate treatment for symptomatic bradyarrhythmia has been invasive surgical implantation of a pacemaker, the discovery of novel therapeutic molecular targets is necessary to improve prognosis and quality of life. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.036761DOI Listing
February 2019
2 Reads

Severe Bradycardia Prior to Coronary Artery Bypass Graft Surgery: A Case Report.

J Tehran Heart Cent 2018 Jul;13(3):136-139

Department of Cardiothoracic Surgery, Barts Heart Centre, St Bartholomew's Hospital, London, UK.

Intraventricular conduction abnormalities following cardiac surgery have been thoroughly described, especially after valvular surgery. It is also widely known that several anesthetic factors can cause autonomic disturbances resulting in the unmasking of sinus node dysfunction, significant bradycardia, and cardiovascular collapse during the intraoperative period. However, little is known about asymptomatic episodes, especially those occurring prior to coronary artery bypass grafting (CABG). Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368915PMC
July 2018
7 Reads

Pulmonary sarcoidosis as a cause of intermittent fever of unknown origin in a hemodialysis patient with renal cell carcinoma: A case report and literature review.

Hemodial Int 2019 Feb 7. Epub 2019 Feb 7.

Department of Kidney Disease, Kawashima Hospital, 1-39 Kitasakoichiban-cho, Tokushima, 770-0011, Japan.

Hemodialysis patients have weakened immune systems and can exhibit fever due to various causes. Herein, we describe the case of a 61-year-old hemodialysis patient who exhibited intermittent low-grade fever after a pacemaker had been implanted 2 months before due to sick sinus syndrome. She had a medical history of subcutaneous sarcoidosis and uveitis. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/hdi.12695
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http://dx.doi.org/10.1111/hdi.12695DOI Listing
February 2019
6 Reads

Indications for permanent pacing in dogs and cats.

J Vet Cardiol 2019 Jan 29. Epub 2019 Jan 29.

Clinica Veterinaria Malpensa, Viale Marconi 27, 21017 Samarate, Varese, Italy.

Pacemaker implantation is considered as a standard procedure for treatment of symptomatic bradycardia in both dogs and cats. Advanced second-degree and third-degree atrioventricular blocks, sick sinus syndrome, persistent atrial standstill, and vasovagal syncope are the most common rhythm disturbances that require pacing to either alleviate clinical signs or prolong survival. Most pacemakers are implanted transvenously, using endocardial leads, but rarely epicardial leads may be necessary. Read More

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http://dx.doi.org/10.1016/j.jvc.2018.12.003DOI Listing
January 2019
4 Reads

Novel Method for Assessment of His Bundle Pacing Morphology Using Near Field and Far Field Device Electrograms.

Circ Arrhythm Electrophysiol 2019 Feb;12(2):e006878

Division of Cardiac Electrophysiology, Rush University Medical Center, Chicago, IL (N.J.S., R.Z., R.T., P.S.S.).

Background: The 12-lead ECG is considered the gold standard to differentiate between selective (S), nonselective (NS) His bundle pacing (HBP), and right ventricular septal capture in routine clinical practice. We sought to assess the utility of device EGM recordings as a tool to identify the type of HBP morphology.

Methods: One hundred forty-eight consecutive patients underwent HBP with a 3830 Select Secure lead (Medtronic, Inc) at 3 centers between October 2016 and October 2017. Read More

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http://dx.doi.org/10.1161/CIRCEP.118.006878DOI Listing
February 2019
1 Read

Polymorphisms of the SCN10A Gene in Patients With Sick Sinus Syndrome.

Kardiologiia 2018 Nov 18;58(4):53-59. Epub 2018 Nov 18.

ФГБОУ ВО «Красноярский государственный медицинский университет им. проф. В. Ф. Войно-Ясенецкого» Минздрава РФ.

Purpose: To study association of rs6795970 polymorphism of SCN10A gene with development of idiopathic sick sinus syndrome (ISSS).

Materials And Methods: We examined 109 patients with ISSS, 59 their healthy 1-st-, 2-nd-, and 3-rd-degree relatives, and 630 controls. Patients with ISSS were divided into subgroups according to gender and clinical variant of the disease. Read More

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http://dx.doi.org/10.18087/cardio.2018.4.10096DOI Listing
November 2018
1 Read

Outcomes of Double-patch and Warden Techniques in Patients with Supracardiac Partial Anomalous Pulmonary Venous Connection.

Heart Lung Circ 2018 Dec 14. Epub 2018 Dec 14.

Congenital Heart Surgery Department, E. Meshalkin National Medical Research Center, Novosibirsk, Russian Federation.

Aim: This study compared outcomes following the double-patch and Warden procedures for correcting partial anomalous connection of the right pulmonary veins to the superior vena cava.

Methods: Eighty patients, aged <18years old, and with partial anomalous connection of the right pulmonary veins to the superior vena cava were randomly assigned into double-patch method (n=40) and Warden procedure (n=40) groups. The median follow-up was 22. Read More

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http://dx.doi.org/10.1016/j.hlc.2018.11.020DOI Listing
December 2018
1 Read

Functional biological pacemaker generation by T-Box18 protein expression via stem cell and viral delivery approaches in a murine model of complete heart block.

Pharmacol Res 2019 Mar 21;141:443-450. Epub 2019 Jan 21.

Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Tehran, Iran; Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Tehran, Iran; School of Medicine, Mashhad University of Medical Sciences, Tehran, Iran.

Despite recent advances in the treatment of cardiac arrhythmia, the available options are still limited and associated with some complications. Induction of biological pacemakers via Tbx18 gene insertion in the heart tissue has been suggested as a promising therapeutic strategy for cardiac arrhythmia. Following a previous in vitro study reporting the production of Tbx18-expressing human induced pluripotent stem cell-derived cardiomyocytes (hiPS-CMs), we aimed to investigate the efficacy of these engineered cells to generate pacemaker rhythms in a murine model of complete heart block. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10436618183177
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http://dx.doi.org/10.1016/j.phrs.2019.01.034DOI Listing
March 2019
6 Reads

Safety and prognostic value of regadenoson stress cardiovascular magnetic resonance imaging in heart transplant recipients.

J Cardiovasc Magn Reson 2019 Jan 24;21(1). Epub 2019 Jan 24.

Cardiovascular Division, Department of Medicine, University of Minnesota Medical Center, 420 Delaware Street SE, MMC 508, Minneapolis, MN, 55455, USA.

Background: There is a critical need for non-invasive methods to detect coronary allograft vasculopathy and to risk stratify heart transplant recipients. Vasodilator stress testing using cardiovascular magnetic resonance imaging (CMR) is a promising technique for this purpose. We aimed to evaluate the safety and the prognostic value of regadenoson stress CMR in heart transplant recipients. Read More

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http://dx.doi.org/10.1186/s12968-018-0515-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345066PMC
January 2019
1 Read
4.556 Impact Factor

Transvenous pacing implantation: techniques, tips, and lessons learned along the way.

J Vet Cardiol 2019 Jan 17. Epub 2019 Jan 17.

Dept. of Pediatrics, University of Florida, College of Medicine, Jacksonville, FL, Gainesville, FL, USA.

The right ventricular apex has been the traditional site for lead placement in veterinary patients who require permanent cardiac pacing therapy for atrioventricular block and sick sinus syndrome. Implantation of leads in this location is a straightforward procedure that most veterinary cardiologists perform routinely. Pacing at the right ventricular apex, however, has been demonstrated to have long-term deleterious effects on the left ventricular function in numerous patient populations and animal models. Read More

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http://dx.doi.org/10.1016/j.jvc.2018.08.002DOI Listing
January 2019
1 Read

Familial Sinus Node Disease Caused by a Gain of GIRK (G-Protein Activated Inwardly Rectifying K Channel) Channel Function.

Circ Genom Precis Med 2019 Jan;12(1):e002238

Department of Cardiovascular Medicine, Institute for Genetics of Heart Diseases (IfGH), University Hospital Münster, Germany (J.K., B.S., S.Z., G.S., E.S.-B.).

Background: Inherited forms of sinus node dysfunction (SND) clinically include bradycardia, sinus arrest, and chronotropic incompetence and may serve as disease models to understand sinus node physiology and impulse generation. Recently, a gain-of-function mutation in the G-protein gene GNB2 led to enhanced activation of the GIRK (G-protein activated inwardly rectifying K channel). Thus, human cardiac GIRK channels are important for heart rate regulation and subsequently, genes encoding their subunits Kir3. Read More

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https://www.ahajournals.org/doi/10.1161/CIRCGEN.118.002238
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http://dx.doi.org/10.1161/CIRCGEN.118.002238DOI Listing
January 2019
12 Reads

Pacemaker programming in patients with first-degree AV-block: Programming pattern and possible consequences.

Health Sci Rep 2018 Jun 9;1(6):e39. Epub 2018 May 9.

Clinical Cardiac Electrophysiology Duke University Medical Center Durham NC USA.

Background: The optimal way of pacing in patients with an indication for pacing and concomitant first-degree atrioventricular (AV)-block is not known, and consequently, firm guidelines on this topic are lacking. This study explored the current pacemaker programming pattern in patients with first-degree AV-block who have a dual chamber pacemaker without cardiac resynchronization.

Methods: The study was a retrospective chart review conducted at Duke University Hospital. Read More

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http://dx.doi.org/10.1002/hsr2.39DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266422PMC
June 2018
2 Reads

Cellular Mechanisms of Sinus Node Dysfunction in Carriers of the -E161K Mutation and Role of the H558R Polymorphism.

Authors:
Ronald Wilders

Front Physiol 2018 18;9:1795. Epub 2018 Dec 18.

Department of Medical Biology, Amsterdam University Medical Centers, Amsterdam, Netherlands.

Carriers of the E161K mutation in the gene, encoding the Na1.5 pore-forming α-subunit of the ion channel carrying the fast sodium current (I), show sinus bradycardia and occasional exit block. Voltage clamp experiments in mammalian expression systems revealed a mutation-induced 2. Read More

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https://www.frontiersin.org/article/10.3389/fphys.2018.01795
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http://dx.doi.org/10.3389/fphys.2018.01795DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305593PMC
December 2018
7 Reads

Identification of a novel exon3 deletion of RYR2 in a family with catecholaminergic polymorphic ventricular tachycardia.

Ann Noninvasive Electrocardiol 2019 Jan 7:e12623. Epub 2019 Jan 7.

Department of Cardiovascular Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan.

Background: RYR2, encoding cardiac ryanodine receptor, is the major responsible gene for catecholaminergic polymorphic ventricular tachycardia (CPVT). Meanwhile, KCNJ2, encoding inward-rectifier potassium channel (I ), can be the responsible gene for atypical CPVT. We recently encountered a family with CPVT and sought to identify a responsible gene variant. Read More

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http://dx.doi.org/10.1111/anec.12623DOI Listing
January 2019
9 Reads

Two methods for modeling of sick sinus syndrome in rats: Ischemia reperfusion and sodium hydroxide induced injury.

Biomed Pharmacother 2019 Mar 4;111:778-784. Epub 2019 Jan 4.

China Academy of Chinese Medicine Sciences, Xiyuan hospital, 100091, China. Electronic address:

The Sick Sinus Syndrome (SSS) is a serious life-threatening heart disease. It is important to establish a credible and stable sinus node damage model. In this study, we use two methods to construct an SSS damage model in rats. Read More

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http://dx.doi.org/10.1016/j.biopha.2018.11.091DOI Listing
March 2019
1 Read

Occurrence of significant long PR intervals in patients implanted for sinus node dysfunction and monitored with SafeR™: The PRECISE study.

Arch Cardiovasc Dis 2018 Dec 26. Epub 2018 Dec 26.

Henri Mondor hospital, 94101 Créteil, France.

Background: Long PR intervals may increase cardiovascular complications, including atrial fibrillation. In pacemakers, the SafeR™ mode monitors PR intervals, switching from AAI to DDD when criteria for atrioventricular block are met.

Aims: The PRECISE study evaluated the incidence and predictors of long PR intervals and their association with incident atrial fibrillation after 1 year in patients implanted for sinus node dysfunction and free from significant conduction disorders at baseline. Read More

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http://dx.doi.org/10.1016/j.acvd.2018.09.005DOI Listing
December 2018
3 Reads

Development of a Rat Model of Sick Sinus Syndrome Using Pinpoint Press Permeation.

Biomed Res Int 2018 18;2018:7487324. Epub 2018 Nov 18.

Fujian Hypertension Research Institute, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.

Objective: Sick sinus syndrome (SSS) is one of the most common causes of cardiac impairment necessitating pacemaker implantation. However, studies of SSS pathogenesis are neither comprehensive nor conclusive due to limited success in achieving a stable rat SSS model. Here, we modified pinpoint press permeation to establish a stable rat SSS model. Read More

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http://dx.doi.org/10.1155/2018/7487324DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276488PMC
November 2018
2 Reads

Selective Use of Temporary Epicardial Pacing Leads in Early Infancy Following Cardiac Surgery: Feasibility and Determinants of Clinical Application.

Pediatr Cardiol 2019 Mar 18;40(3):630-637. Epub 2018 Dec 18.

Department of Surgery, Medical College of Georgia, Augusta, GA, USA.

Use of temporary epicardial pacing (TEP) leads remains a routine perioperative strategy in congenital heart surgery. Selective use of TEP in neonates and infants undergoing cardiac intervention within the first 6 months of life has, yet, to be assessed. Outcome analysis was undertaken. Read More

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http://dx.doi.org/10.1007/s00246-018-2037-yDOI Listing

Pulmonary veins isolation to retard pacemaker implantation.

Clin Case Rep 2018 Dec 30;6(12):2445-2450. Epub 2018 Oct 30.

Cardiology Centre Hospitalier Universitaire Dinant/Godinne Yvoir Belgium.

Sick sinus syndrome is uncommon in children, and syndromic forms are rare. Some forms of sick sinus syndrome like the bradycardia-tachycardia type could be managed by a radiofrequency ablation, even in young children, and could be helpful to delay the implantation of a pacemaker. Read More

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http://dx.doi.org/10.1002/ccr3.1865DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293180PMC
December 2018
3 Reads

Canine and human sinoatrial node: differences and similarities in the structure, function, molecular profiles, and arrhythmia.

J Vet Cardiol 2018 Dec 14. Epub 2018 Dec 14.

Department of Physiology and Cell Biology, Dorothy M. Davis Heart & Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH, USA. Electronic address:

The sinoatrial node (SAN) is the primary pacemaker in canine and human hearts. The SAN in both species has a unique three-dimensional heterogeneous structure characterized by small pacemaker myocytes enmeshed within fibrotic strands, which partially insulate the cells from aberrant atrial activation. The SAN pacemaker tissue expresses a unique signature of proteins and receptors that mediate SAN automaticity, ion channel currents, and cell-to-cell communication, which are predominantly similar in both species. Read More

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http://dx.doi.org/10.1016/j.jvc.2018.10.004DOI Listing
December 2018
2 Reads

Persistence of a pacemaker lead-like "ghost" 6 months after lead extraction.

Echocardiography 2019 01 9;36(1):201-203. Epub 2018 Dec 9.

Rajaie Cardiovascular Medical & Research Center, Tehran, Iran.

Residual fibrous structures, referred as "ghosts", are occasionally encountered following lead extraction. Though typically detected in patients with cardiac device infections, their prognostic and therapeutic implications remain speculative. We describe a 62-year-old gentleman with history of sick sinus syndrome who presented atrial fibrillation with rapid ventricular response. Read More

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http://dx.doi.org/10.1111/echo.14224DOI Listing
January 2019
3 Reads

Atrial fibrillation occurring during head-up tilt testing: Once detected, atrial fibrillation should be monitored, regardless of how it is detected.

Heart Rhythm 2018 Dec 5. Epub 2018 Dec 5.

Division of Cardiology, Department of Internal Medicine, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

Background: Atrial fibrillation (AF) often progresses to more sustained forms and increases the risk of ischemic stroke or sinus node dysfunction. However, there have been no data on the clinical outcomes of patients who developed AF during head-up tilt testing (HUT).

Objective: The purpose of this study was to evaluate the clinical significance of AF detected during HUT performed for syncope evaluation. Read More

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http://dx.doi.org/10.1016/j.hrthm.2018.11.030DOI Listing
December 2018
8 Reads
5.076 Impact Factor

An Itchy Lead: First Reported Case of Ventricular Pacemaker Lead Self-Extraction.

J Atr Fibrillation 2018 Aug 31;11(2):2052. Epub 2018 Aug 31.

Division of Cardiology, Altru Health System, Grand Forks, North Dakota 58201.

We present a particularly rare case and the first ever report of a ventricular self-extraction in a 98-year old female. Our patient had a past medical history significant for severe Alzheimer's dementia, paroxysmal atrial fibrillation, and sick sinus syndrome who was admitted in clinically stable condition following the unwitnessed self-extraction the ventricular lead of her dual chamber pacemaker. This case highlights the potential risks and other clinical challenges of pacemaker and ICD placement in elderly patients and in patients with cognitive impairment. Read More

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http://dx.doi.org/10.4022/jafib.2052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244303PMC
August 2018
2 Reads

The first successful implantation of an intravenous AAIR pacemaker into autologous extracardiac lateral tunnel Fontan in the child.

J Electrocardiol 2018 Nov - Dec;51(6):1015-1018. Epub 2018 Jul 27.

Department of Cardiology, Congenital Heart Diseases and Electrotherapy, Silesian Center for Heart Diseases, Zabrze, Poland; Department of Dietetics, School of Public Health in Bytom, Medical University of Silesia, Katowice, Poland.

Patients with a single ventricle have complex anatomy that requires staged palliation which is usually the Fontan procedure. This procedure has undergone a lot of modifications to improve hemodynamics. Despite these efforts, sinus node dysfunction (SND) and bradyarrythmias are still common complications after Fontan operation, therefore there is a need of pacemakers implantation. Read More

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http://dx.doi.org/10.1016/j.jelectrocard.2018.07.019DOI Listing
July 2018
2 Reads

Dysrhythmias in patients with a complete atrioventricular septal defect: From surgery to early adulthood.

Congenit Heart Dis 2018 Nov 28. Epub 2018 Nov 28.

Department of Cardiothoracic Surgery, Erasmus University Medical Center, Rotterdam, The Netherlands.

Objective: Outcomes after surgical repair of complete atrioventricular septal defect (cAVSD) have improved. With advancing age, the risk of development of dysrhythmias may increase. The aims of this study were to (1) examine development of sinus node dysfunction (SND), atrial and ventricular tachyarrhythmias, and (2) study progression of atrioventricular conduction abnormalities in young adult patients with repaired cAVSD. Read More

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http://dx.doi.org/10.1111/chd.12724DOI Listing
November 2018
3 Reads

Cyclical sinus bradycardia and atrioventricular block induced by ticagrelor.

HeartRhythm Case Rep 2018 Nov 8;4(11):527-529. Epub 2018 Aug 8.

Department of Cardiology, Montreal Heart Institute, Université de Montréal, Montreal, Canada.

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http://dx.doi.org/10.1016/j.hrcr.2018.07.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6241168PMC
November 2018
2 Reads

Three-Dimensional Printing Technology Combined With Postmortem Computed Tomography Angiography as New Form of Forensic Evidence: A Case Report.

Am J Forensic Med Pathol 2019 Mar;40(1):61-64

Shanghai Key Laboratory of Forensic Medicine, Academy of Forensic Science, Shanghai, China.

Postmortem computed tomography (PMCT) and PMCT angiography are increasingly used in forensic practice. However, their application in court is still limited because they need professional equipment or software to be displayed. In this article, the authors introduce 3-dimensional (3D) printing technology as a new approach to provide evidence in court. Read More

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http://dx.doi.org/10.1097/PAF.0000000000000443DOI Listing
March 2019
15 Reads

Surgical repair of partial anomalous pulmonary venous return with intact atrial septum in a 65-year-old woman: a case report.

J Med Case Rep 2018 Nov 24;12(1):350. Epub 2018 Nov 24.

Department of General and Cardiothoracic Surgery, Graduate School of Medicine, Gifu University, 1-1 Yanagido, Gifu City, 501-1194, Japan.

Background: Partial anomalous pulmonary venous return is a rare congenital cardiac anomaly that usually involves the right pulmonary vein and an atrial septal defect. Isolated partial anomalous pulmonary venous return with an intact atrial septum is even rarer, and this condition is usually treated surgically in younger patients. We describe isolated partial anomalous pulmonary venous return in a 65-year-old woman who was treated by caval division with pericardial patch baffling through a surgically created atrial septal defect and reconstruction of the superior vena cava using a prosthetic graft. Read More

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http://dx.doi.org/10.1186/s13256-018-1874-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260651PMC
November 2018
11 Reads

Sick Sinus Syndrome Observed in a Patient with Cholinesterase Deficiency.

Intern Med 2018 Nov 19. Epub 2018 Nov 19.

Heart Center, Kyushu University Hospital, Japan.

A 58-year-old woman complained of general fatigue and was diagnosed with sick sinus syndrome (SSS) by ambulatory electrocardiogram, which demonstrated sinus arrest at midnight and paroxysmal atrial fibrillation (AF) at nighttime. Since her plasma cholinesterase (ChE) activity had been persistently zero, she was diagnosed with ChE deficiency. She refused permanent pacemaker implantation, and treatment with positive chronotropic drugs is ongoing. Read More

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https://www.jstage.jst.go.jp/article/internalmedicine/advpub
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http://dx.doi.org/10.2169/internalmedicine.1229-18DOI Listing
November 2018
11 Reads

Pleiotropic effects of schizophrenia-associated genetic variants in neuron firing and cardiac pacemaking revealed by computational modeling.

Transl Psychiatry 2017 11 17;7(11). Epub 2017 Nov 17.

NORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.

Schizophrenia patients have an increased risk of cardiac dysfunction. A possible factor underlying this comorbidity are the common variants in the large set of genes that have recently been discovered in genome-wide association studies (GWASs) as risk genes of schizophrenia. Many of these genes control the cell electrogenesis and calcium homeostasis. Read More

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http://dx.doi.org/10.1038/s41398-017-0007-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802468PMC
November 2017
1 Read

Clinical characteristics and outcome of lone atrial fibrillation at a tertiary referral centre: the Groote Schuur Hospital experience.

Cardiovasc J Afr 2018 Sep/Oct;29(5):268-272

The Cardiac Clinic, Department of Medicine, Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa.

Introduction: Atrial fibrillation (AF) is a relatively common arrhythmia. When AF represents an electrophysiological phenomenon in structurally normal hearts, it is termed lone AF. This study was a retrospective, case-based analysis of patients attending the Cardiac Clinic at Groote Schuur Hospital (GSH) and describes the clinical characteristics and outcomes of patients classified as having lone atrial fibrillation. Read More

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http://cvja.co.za/onlinejournal/vol29/vol29_issue5/#6/z
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http://dx.doi.org/10.5830/CVJA-2018-005DOI Listing
May 2017
9 Reads

Evaluation of a near-zero fluoroscopic approach for catheter ablation in patients with congenital heart disease.

J Interv Card Electrophysiol 2018 Oct 30. Epub 2018 Oct 30.

Electrophysiology Section, Cardiology Department, Hospital Universitari i Politècnic La Fe, Área de Enfermedades Cardiovasculares, Planta 4-Torre F, Av. Fernando Abril Martorell, 106, 46026, Valencia, Spain.

Purpose: Radiation exposure (RE) is a matter of concern for patients with congenital heart disease (CHD) who not infrequently need multiple interventional procedures under fluoroscopy guidance. We sought to evaluate the safety and feasibility of a minimally fluoroscopic approach in patients with CHD undergoing catheter ablation using a new image integration module (IIM).

Methods: Consecutive patients with CHD undergoing catheter ablation using the Carto Univu™ IIM were included. Read More

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http://dx.doi.org/10.1007/s10840-018-0467-3DOI Listing
October 2018
4 Reads

Role of the monocyte-to-high-density lipoprotein ratio in predicting atrial high-rate episodes detected by cardiac implantable electronic devices.

Authors:
Seckin Satilmis

North Clin Istanb 2018 12;5(2):96-101. Epub 2018 Apr 12.

Department of Cardiology, Acibadem Atakent University Hospital, Istanbul, Turkey.

Objective: Technological advances have allowed cardiac implantable electronic devices (CIEDs) to detect, analyze, and store atrial high-rate episodes (AHREs), which are surrogate for the term silent atrial fibrillation (AF). The association of AHREs with adverse clinical events has been demonstrated in several recent studies, implying that morbidity and mortality can be significantly prevented by prompt recognition and intervention. Inflammation and oxidative stress are among several mechanisms that contribute to the pathogenesis of AF. Read More

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http://www.kuzeyklinikleri.com/jvi.aspx?pdir=nci&plng=tu
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http://dx.doi.org/10.14744/nci.2017.35761DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191558PMC
April 2018
7 Reads