5,441 results match your criteria Sinus Node Dysfunction


Extracardiac Vagal Stimulation-Assisted Cardioneuroablation: Dynamically Evaluating the Impact of Sequential Ganglionated Plexus Ablation on Vagal Control of SAN and AVN in Patients with Sinoatrial Node Dysfunction.

J Cardiovasc Dev Dis 2022 Jun 10;9(6). Epub 2022 Jun 10.

Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China.

Cardioneuroablation (CNA) is proposed as a promising therapy for patients with sinoatrial node dysfunction (SND) that is mediated by excessive vagal tone. However, a series of urgent questions about CNA remain unanswered. From December 2020 to March 2022, six patients with symptomatic SND who underwent CNA were summarized in this report. Read More

View Article and Full-Text PDF

Efficacy and Safety of a Combined Aerobic, Strength and Flexibility Exercise Training Program in Patients with Implantable Cardiac Devices.

J Cardiovasc Dev Dis 2022 Jun 6;9(6). Epub 2022 Jun 6.

Institute of Sports Medicine, Sport e Salute, 00197 Rome, Italy.

: The "FIDE Project" (Fitness Implantable DEvice) was organized by the Institute of Sports Medicine and Science and the World Society of Arrhythmias with the aim of demonstrating the usefulness of exercise training in improving functional capacity in patients with implantable cardiac devices. : Thirty sedentary patients were selected for the project (25 males and 5 females), with a mean age of 73 ± 5 years (range 44-94 years). Twenty-five were implanted with a Pacemaker (PM) and five with an Implantable Cardioverter Defibrillator (ICD). Read More

View Article and Full-Text PDF

Longitudinal electrocardiographic assessment in Brugada syndrome.

Heart Rhythm O2 2022 Jun 8;3(3):233-240. Epub 2022 Feb 8.

Electrophysiology Section, Division of Cardiovascular Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.

Background: The type 1 electrocardiographic (ECG) pattern diagnostic of Brugada syndrome (BrS) can be dynamic. Limited studies have rigorously evaluated the temporal stability of the Brugada ECG pattern.

Objective: We sought to evaluate fluctuations of the Brugada pattern in serial resting ECGs from BrS patients managed within a large health care system. Read More

View Article and Full-Text PDF

Systemic sclerosis and tachycardia-bradycardia syndrome: a case report.

J Med Case Rep 2022 Jun 21;16(1):258. Epub 2022 Jun 21.

Mohammed V University of Rabat, Rabat, Morocco.

Background: Systemic sclerosis is a multisystemic character autoimmune disease. It is characterized by vascular dysfunction and progressive fibrosis affecting mainly the skin but also different internal organs. All heart structures are commonly affected, including the pericardium, myocardium, and conduction system. Read More

View Article and Full-Text PDF

Inappropriate Sinus Tachycardia: Etiology, Pathophysiology, and Management: JACC Review Topic of the Week.

J Am Coll Cardiol 2022 Jun;79(24):2450-2462

Kansas City Heart Rhythm Institute, Overland Park, Kansas, USA. Electronic address:

Inappropriate sinus tachycardia (IST) is a clinical syndrome that generally affects young patients and is associated with distressing symptoms. Although the most common symptom is palpitations, it can be accompanied by a myriad of symptoms, including anxiety, dizziness, presyncope, and syncope. The pathogenesis of IST is not well understood and considered multifactorial, with autonomic dysfunction being the central abnormality. Read More

View Article and Full-Text PDF

Meta-analysis of cardiovascular outcome trials assessing the impact of glucagon-like peptide-1 receptor agonists on major cardiac arrhythmias.

Acta Cardiol 2022 Jun 14:1-6. Epub 2022 Jun 14.

Third Department of Cardiology, Ippokratio General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Objective: Glucagon-like peptide-1 receptor agonists (GLP-1RAs), a group of novel antidiabetic agents, demonstrated beneficial cardiovascular effects in recent large, placebo-controlled randomised clinical trials (RCTs); their clear antiarrhythmic benefit has not been yet underlined. The purpose of the present meta-analysis is to clarify the impact of GLP-1RAs on different types of cardiac arrhythmias.

Methods: We searched PubMed from its inception up to 8 October 2020 for all available cardiovascular and renal outcome, placebo-controlled RCTs utilising GLP-1RAs versus placebo. Read More

View Article and Full-Text PDF

[Clinical case of the cardiovascular system involvement in a patient with Charcot-Marie-Tooth disease].

Kardiologiia 2022 May 31;62(5):67-71. Epub 2022 May 31.

Medical Research and Educational Center, Lomonosov Moscow State University.

Hereditary motor and sensory type 1A neuropathy (known as Charcot-Marie-Tooth disease) is a disease of peripheral nerves characterized by symptoms of progressive polyneuropathy with preferential damage of distal extremity muscles. Damage to the cardiovascular system is extremely rare and heterogenous in this pathology. This disease is not included in the list of indications for interventional antiarrhythmic aid. Read More

View Article and Full-Text PDF

Sinus Node Dysfunction after Successful Atrial Flutter Ablation during Follow-Up: Clinical Characteristics and Predictors.

J Clin Med 2022 Jun 4;11(11). Epub 2022 Jun 4.

Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei 11217, Taiwan.

Identification of sinus node dysfunction (SND) before termination of persistent AFL by catheter ablation (CA) is challenging. This study aimed to investigate the characteristics and predictors of acute and delayed SND after AFL ablation. We retrospectively enrolled 221 patients undergoing CA of persistent AFL in a tertiary referral center. Read More

View Article and Full-Text PDF

Permanent pacing in a very long-term follow-up after orthotopic heart transplantation: A matter of when or why?

Ann Noninvasive Electrocardiol 2022 Jun 7:e12979. Epub 2022 Jun 7.

Department of Cardiology I - Coronary and Peripheral Vascular Disease, Heart Failure, University Hospital Muenster, Muenster, Germany.

Background: Orthotopic heart transplantation (OHT) is associated with a high incidence of conduction disturbances (CD) leading to permanent pacemaker (PPM) implantation. However, the improved posttransplant survival raises the question about the pacemaker dependence (PD) in a prolonged follow-up.

Hypothesis: The prevalence of PPM in OHT is high but not all patients are PD in a very long-term follow-up. Read More

View Article and Full-Text PDF

Syncope in a pregnant woman with repaired Tetralogy of Fallot: a case report.

Eur Heart J Case Rep 2022 Jun 24;6(6):ytac209. Epub 2022 May 24.

Nork-Marash Medical Center, Armenak Armenakyan St. 13, 0047 Yerevan, Armenia.

Background: Tetralogy of Fallot (TOF) is one of the most widespread cyanotic congenital heart disease (CHD), which can be successfully repaired in the neonatal period. However, residual problems and the surgical technique itself can create a favourable basis for arrhythmias and conduction abnormalities in these patients. Sometimes, these arrhythmias may worsen during pregnancy and require urgent intervention. Read More

View Article and Full-Text PDF

Assessment of New Onset Arrhythmias After Transcatheter Aortic Valve Implantation Using an Implantable Cardiac Monitor.

Front Cardiovasc Med 2022 16;9:876546. Epub 2022 May 16.

Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

Background: Transcatheter aortic valve implantation (TAVI) is associated with new onset brady- and tachyarrhythmias which may impact clinical outcome.

Aims: To investigate the true incidence of new onset arrhythmias within 12 months after TAVI using an implantable cardiac monitor (ICM).

Methods: One hundred patients undergoing TAVI received an ICM within 3 months before or up to 5 days after TAVI. Read More

View Article and Full-Text PDF

A single-centre experience of His bundle pacing without electrophysiological mapping system: implant success rate, safety, pacing characteristics and one-year follow up.

Singapore Med J 2022 Jun 2. Epub 2022 Jun 2.

Cardiology Department, Changi General Hospital, Singapore.

Introduction: Despite the challenges related to His bundle pacing (HBP), recent data suggest an improved success rate with experience. As a non-university, non-electrophysiology specialised centre in Singapore, we report our experiences in HBP using pacing system analyser alone.

Methods: Data of 28 consecutive patients who underwent HBP from August 2018 to February 2019 was retrospectively obtained. Read More

View Article and Full-Text PDF

An Adolescent Patient with Sick Sinus Syndrome Complicated by Hypothyroidism Carrying an SCN5A Variant.

Int Heart J 2022 ;63(3):627-632

Department of Pediatrics, Jichi Medical University.

Previous studies have reported that hypothyroidism can lead to sick sinus syndrome (SSS) or other rhythm disturbances. Variants in the alpha subunit of the cardiac sodium channel (SCN5A) are known to be among the genetic causes of SSS. We encountered an adolescent patient with SSS and hypothyroidism who also harbored an SCN5A variant. Read More

View Article and Full-Text PDF

Isolated coagulopathy without classic CRAB symptoms as the initial manifestation of multiple myeloma: A case report.

World J Clin Cases 2022 Apr;10(12):3822-3827

Department of Hematology, Mianyang Central Hospital, Mianyang 621000, Sichuan Province, China.

Background: Multiple myeloma patients usually present with CRAB symptoms (hypercalcemia, renal disease, anemia and bone diseases) as initial manifestations. Bleeding symptoms are less common, most of which result from thrombocytopenia or infiltration of plasmacytoma. Relatively, coagulopathy is not so common, especially isolated coagulopathy without CRAB manifestations, which is very rare. Read More

View Article and Full-Text PDF

Implantation of Watchman FLX for Patients with Difficult Left Atrial Appendage Anatomy: A Case-Based Discussion: Echocardiographic difference of Watchman FLX.

Curr Probl Cardiol 2022 May 26:101266. Epub 2022 May 26.

Department of Cardiology, Ochsner Medical Center, 1514 Jefferson Highway, New Orleans, LA 70118, USA; The University of Queensland School of Medicine, Ochsner Clinical School, New Orleans, LA. Electronic address:

Left atrial appendage (LAA) occlusion devices provided an acceptable and valid alternative to (AC) among patients with atrial fibrillation (AF) who carry high bleeding risk. Watchman device is non-inferior to oral AC to prevent cerebrovascular accidents. The presence of a longer distal portion of the older generation Watchman led to exclusion of patients with prohibitive anatomy of the LAA such as chicken-wing morphology or shallow LAA. Read More

View Article and Full-Text PDF

Transseptal versus left atrial approach for mitral valve surgery: postoperative need for pacemaker.

Eur J Cardiothorac Surg 2022 May 28. Epub 2022 May 28.

Department of Cardiac Surgery, Triemli Hospital, Zurich, Switzerland.

Objectives: Concerns exist about higher rates of pacemaker implantation using the extended superior transseptal approach for mitral valve surgery. This study aims to compare the extended superior transseptal and the left-atrial approach regarding the need for pacemaker implantation after mitral valve surgery.

Methods: We performed a retrospective analysis of the data of patients undergoing mitral valve surgery through either a sternotomy and transseptal approach or a mini-thoracotomy and left-atrial approach in a single center in the period 01/2010-05/2021. Read More

View Article and Full-Text PDF

Cardiac Implantable Electronic Devices in the Fontan Patient.

Can J Cardiol 2022 May 17. Epub 2022 May 17.

Adult Congenital Heart Disease Center, Montreal Heart Institute, Medicine Department, Université de Montréal, Montréal, Québec, Canada.

As a result of remarkable progress in operative techniques and cardiology care during childhood, Fontan patients continue to age and require team-based multidisciplinary expertise to manage complications encountered in adulthood. They face particular challenges in terms of altered hemodynamic stressors, cardiac and hepatic failure, and arrhythmias. Arrhythmias in Fontan patients are highly prevalent and associated with underlying anatomy, surgical technique, and postoperative sequelae. Read More

View Article and Full-Text PDF

Durability of left bundle branch area pacing.

J Cardiovasc Electrophysiol 2022 May 18. Epub 2022 May 18.

Department of Electrophysiology, Lehigh Valley Heart Institute, Allentown, Pennsylvania, USA.

Background: Left bundle branch area pacing (LBBAP) is a form of conduction system pacing. Long-term data on the safety and performance of LBBAP 1 year postdevice implantation has not been well described.

Methods And Results: Sixty-five patients (49% females) who received LBBAP for bradycardia indications using the SelectSecure 3830 lead (Medtronic) were retrospectively evaluated. Read More

View Article and Full-Text PDF

The efficacy of pacemaker implantation for extracardiac total cavopulmonary connection in a pediatric patient with bradycardia-tachycardia syndrome.

J Cardiol Cases 2022 May 22;25(5):255-258. Epub 2021 Nov 22.

Department of Pediatrics, Toyama Prefectural Central Hospital, 2-2-78 Nishinagae-cho, Toyama-shi, Toyama, 930-8550, Japan.

A 9-year-old boy, diagnosed with double outlet right ventricle after birth, suffered sinus node dysfunction and non-sustained junctional tachycardia after an extracardiac total cavopulmonary connection (TCPC). Spontaneous atrial tachycardia appeared 3 years after an extracardiac TCPC. Sotalol was administered but the bradycardia was obvious. Read More

View Article and Full-Text PDF

Prolonged sinus arrest due to the obstruction of a sinus node branch after percutaneous coronary intervention of the right coronary artery.

J Cardiol Cases 2022 May 31;25(5):319-322. Epub 2021 Dec 31.

Department of Cardiology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan.

Myocardial ischemia due to narrowing of the right coronary artery (RCA) may result in sinus arrhythmias, which usually present as transient sinus bradycardia with no hemodynamic instability. We report a rare case of sinus arrest with hemodynamic instability, which lasted for several months, and was caused by the occlusion of the sinus node (SN) artery following the RCA stenting. A 78-year-old woman with diabetes mellitus, hypertension, and dyslipidemia was referred to our hospital because of chest pain during activity. Read More

View Article and Full-Text PDF

Mitral valvuloplasty with left atrial appendage closure and pacemaker implantation in a dog with severe myxomatous mitral valve degeneration: a case report.

BMC Vet Res 2022 May 16;18(1):184. Epub 2022 May 16.

VCA Japan Shiraishi Animal Hospital, Saitama, 350-1304, Japan.

Background: Mitral valvuloplasty (MVP) has been widely recognized as a treatment option for myxomatous mitral valve disease (MMVD). However, postoperative complications such as thromboembolism, arrhythmia, and pancreatitis in some cases have resulted in death. We treated a dog with severe MMVD complicated by impaired sinus function with MVP and pacemaker implantation. Read More

View Article and Full-Text PDF

Functional Heterogeneity of Cell Populations Increases Robustness of Pacemaker Function in a Numerical Model of the Sinoatrial Node Tissue.

Front Physiol 2022 27;13:845634. Epub 2022 Apr 27.

Intramural Research Program, National Institute on Aging, NIH, Baltimore, MD, United States.

Each heartbeat is initiated by specialized pacemaker cells operating within the sinoatrial node (SAN). While individual cells within SAN tissue exhibit substantial heterogeneity of their electrophysiological parameters and Ca cycling, the role of this heterogeneity for cardiac pacemaker function remains mainly unknown. Here we investigated the problem numerically in a 25 × 25 square grid of connected coupled-clock Maltsev-Lakatta cell models. Read More

View Article and Full-Text PDF

Left bundle branch area pacing in patients with atrioventricular conduction disease: A prospective multicenter study.

Heart Rhythm 2022 May 10. Epub 2022 May 10.

Division of Cardiology, Pauley Heart Center, Virginia Commonwealth University, Richmond, Virginia.

Background: The reported success rate of His-bundle pacing (HBP) in patients with infranodal atrioventricular (AV) conduction disease is only 52%-76%. The success rate of left bundle branch area pacing (LBBAP) in this cohort is not well studied.

Objective: The purpose of this study was to evaluate the feasibility, safety, and electrophysiological characteristics of LBBAP in patients with AV conduction disease. Read More

View Article and Full-Text PDF

Long-term results of the Warden procedure for right partial anomalous pulmonary venous connection.

Cardiol Young 2022 May 12:1-6. Epub 2022 May 12.

Medical-Surgical Department of Pediatric and Congenital Cardiology, Pediatric and Adult Congenital Cardiac Surgery, Hospital for Children and Adolescents, 7 quai Moncousu, 44093NantesCedex 1, France.

Introduction: Surgery is considered as the first-line therapeutic strategy of partial anomalous pulmonary venous connection. The Warden technique has very good short-term results. The aim of this study is to evaluate the stability of these good results over a long period of follow-up. Read More

View Article and Full-Text PDF

Early versus late Catheter Ablation of Atrial Fibrillation and Risk of Permanent Pacemaker Implantation in patients with underlying Sinus Node Dysfunction.

J Am Heart Assoc 2022 May 10:e023333. Epub 2022 May 10.

Heart and Vascular Institute MetroHealth Medical Center Case Western Reserve University Cleveland OH.

Background Atrial fibrillation (AF) is associated with anatomical and electrical remodeling. Some patients with AF have concomitant sick sinus syndrome (SSS) and may need permanent pacemaker (PPM) implantation. Association between catheter ablation of AF (CA) timing and need for PPM in SSS has not been assessed. Read More

View Article and Full-Text PDF

An Atrial Septal Ridge Diagnosed by Transesophageal Echocardiography.

Methodist Debakey Cardiovasc J 2022 18;18(1):14-16. Epub 2022 Apr 18.

Houston Methodist DeBakey Heart & Vascular Center, Houston, Texas, US.

A left atrial ridge is an anomaly of irregular fusion between the septum primum and septum secundum.1 Aberrant fusion of the septa results in thickened and fibrotic tissue along the region of the fossa ovalis that will occasionally protrude into the left atrium.2 The presence of a left atrial ridge has multiple clinical implications due to its close proximity to the fossa ovalis. Read More

View Article and Full-Text PDF

Sinus Arrest in Asymptomatic COVID-19 Infection.

Cureus 2022 Apr 1;14(4):e23736. Epub 2022 Apr 1.

Department of Emergency Medicine, Henry Ford Health, Wyandotte, USA.

Coronavirus disease 2019 (COVID-19) is a viral respiratory tract syndrome capable of affecting a multitude of major organs in the human body. It is a known cause of severe vascular compromise, myocardial ischemia, myocarditis, and various cardiac dysrhythmias. Dysfunction of the sinoatrial (SA) node, the primary pacemaker of the heart, can arise from structural heart disease, medications, electrolyte abnormalities, and hypothyroidism. Read More

View Article and Full-Text PDF

Implantation of a leadless pacemaker in a patient with mechanical tricuspid valve.

HeartRhythm Case Rep 2022 Apr 28;8(4):284-287. Epub 2022 Jan 28.

Department of Thoracic and Cardiovascular Surgery, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu, Republic of Korea.

View Article and Full-Text PDF

A Rare Presentation of Sick Sinus Syndrome: Generalized Seizures.

Cureus 2022 Mar 29;14(3):e23631. Epub 2022 Mar 29.

Cardiology, Trinitas Regional Medical Center, Elizabeth, USA.

Cardiac and neurological disorders are the main broad etiologies for loss of consciousness. Ictal bradycardia syndrome refers to epileptic discharges that profoundly disrupt normal cardiac rhythm, resulting in cardiogenic syncope during the ictal event. Convulsive syncope is a well-described phenomenon in both adults and children in which abrupt cerebral hypoperfusion leads to brief extensor stiffening and non-sustained myoclonus. Read More

View Article and Full-Text PDF

COVID-19 and Cardiac Arrhythmias: a Contemporary Review.

Curr Treat Options Cardiovasc Med 2022 19;24(6):87-107. Epub 2022 Apr 19.

Kansas City Heart Rhythm Institute, Overland Park, KS USA.

Purpose Of Review: A significant proportion of patients infected by the severe acute respiratory syndrome-coronavirus (SARS-CoV2) (COVID-19) also have disorders affecting the cardiac rhythm. In this review, we provide an in-depth review of the pathophysiological mechanisms underlying the associated arrhythmic complications of COVID-19 infection and provide pragmatic, evidence-based recommendations for the clinical management of these conditions.

Recent Findings: Arrhythmic manifestations of COVID-19 include atrial arrhythmias such as atrial fibrillation or atrial flutter, sinus node dysfunction, atrioventricular conduction abnormalities, ventricular tachyarrhythmias, sudden cardiac arrest, and cardiovascular dysautonomias including the so-called long COVID syndrome. Read More

View Article and Full-Text PDF