5,231 results match your criteria Sinus Node Dysfunction

Clinical review of sick sinus syndrome and atrial fibrillation.

Herz 2021 Jun 22. Epub 2021 Jun 22.

Department of Ultrasound, the Second Affiliated Hospital of Dalian Medical University, 116027, Dalian, China.

Sick sinus syndrome (SSS) is a set of diseases with abnormal cardiac pacing, which manifests as diverse cardiac arrhythmias, especially bradycardia. The clinical presentation is inconspicuous in the early stage, but with the progression of this disease, patients may present with symptoms and signs of end-organ hypoperfusion. As a common result in the natural history of the disease, SSS coexisting with atrial fibrillation (AF) forms the basis of bradycardia-tachycardia syndrome. Read More

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Sick sinus syndrome associated with Erdheim-Chester disease was reversed by interferon-alpha treatment.

Korean J Intern Med 2021 Jun 15. Epub 2021 Jun 15.

Department of Cardiology, West China Hospital, Sichuan University, Chengdu, China.

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Heart rate score, a measure related to chronotropic incompetence in pacemaker patients.

Heart Rhythm O2 2021 Apr 20;2(2):124-131. Epub 2021 Feb 20.

Cleveland Clinic, Cleveland, Ohio.

Background: Heart rate score (HrSc) ≥70% in cardiac resynchronization therapy defibrillator and implantable cardioverter-defibrillator subjects predicts 5-year mortality risk. A high HrSc suggests few sensed cardiac cycles above the programmed lower rate.

Objective: To determine if HrSc is related to chronotropic incompetence (CI) in pacemaker (PM) subjects. Read More

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Lacosamide-induced sinus node dysfunction followed by severe agranulocytosis.

BMC Neurol 2021 Jun 8;21(1):217. Epub 2021 Jun 8.

Department of Neurology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, 371-8511, Gunma, Japan.

Background: Lacosamide (LCM) is the antiepileptic drug approved by the U.S. Food and Drug Administration in 2008 that facilitates slow activation of the voltage-gated sodium channels. Read More

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Risk of sudden cardiac death in EXOSC5-related disease.

Am J Med Genet A 2021 Jun 4. Epub 2021 Jun 4.

Department of Pediatrics, Division of Cardiology, Texas Children's Hospital, Houston, Texas, USA.

The RNA exosome is a multi-subunit complex involved in the processing, degradation, and regulated turnover of RNA. Several subunits are linked to Mendelian disorders, including pontocerebellar hypoplasia (EXOSC3, MIM #614678; EXOSC8, MIM #616081: and EXOSC9, MIM #618065) and short stature, hearing loss, retinitis pigmentosa, and distinctive facies (EXOSC2, MIM #617763). More recently, EXOSC5 (MIM *606492) was found to underlie an autosomal recessive neurodevelopmental disorder characterized by developmental delay, hypotonia, cerebellar abnormalities, and dysmorphic facies. Read More

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Tricuspid regurgitation associated with implantable electrical device insertion: a systematic review and meta-analysis.

Pacing Clin Electrophysiol 2021 Jun 3. Epub 2021 Jun 3.

Division of Cardiac Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

Background: Implantable cardioverter defibrillator (ICD) and permanent pacemaker (PPM) lead placement may worsen or result in tricuspid regurgitation (TR). While the association between lead placement and the incidence of TR has been established, current understanding of this problem remains incomplete. This systematic review and meta-analysis sought to pool the existing evidence to better understand the occurrence and severity of TR associated with cardiac implantable electrical device (CIED) insertion. Read More

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Sick Sinus Syndrome Mimicking Autonomic Dysfunction of Dementia With Lewy Bodies.

Cureus 2021 Apr 24;13(4):e14667. Epub 2021 Apr 24.

Psychiatry, Otaru General Hospital, Otaru, JPN.

Dementia with Lewy bodies (DLB) is recognized as the second most common form of dementia in aged people. It is well known that patients with DLB often develop various autonomic symptoms. Here, we present a case in which there was sick sinus syndrome mimicking the DLB-related autonomic dysfunctions. Read More

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Intracellular Na Modulates Pacemaking Activity in Murine Sinoatrial Node Myocytes: An Analysis.

Int J Mol Sci 2021 May 26;22(11). Epub 2021 May 26.

Department of Pharmacology, University of California Davis, Davis, CA 95616, USA.

: The mechanisms underlying dysfunction in the sinoatrial node (SAN), the heart's primary pacemaker, are incompletely understood. Electrical and Ca-handling remodeling have been implicated in SAN dysfunction associated with heart failure, aging, and diabetes. Cardiomyocyte [Na] is also elevated in these diseases, where it contributes to arrhythmogenesis. Read More

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Impact of COVID-19 Pandemic on the Implantation of Intra-Cardiac Devices in Diabetic and Non-Diabetic Patients in the Western of Romania.

Medicina (Kaunas) 2021 May 3;57(5). Epub 2021 May 3.

Department VII, Internal Medicine II, Discipline of Cardiology, University of Medicine and Pharmacy "Victor Babes" Timisoara, E. Murgu Square, Nr. 2, 300041 Timisoara, Romania.

: COVID-19 pandemic severely impacted public health services worldwide, determining a significant decrease of elective cardiovascular (CV) procedures, especially in patients with associated chronic diseases such as diabetes mellitus (DM). : This study was first started in 2019 in the western of Romania, to analyze the differences regarding the implantations of intra-cardiac devices such as permanent pacemakers (PPM), cardiac resynchronization therapy (CRT), or implantable cardioverter-defibrillators (ICD) in 351 patients with and without DM and the situation was reanalyzed at the end of 2020. : of the first 351 patients with and without DM. Read More

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Yixin-Fumai granules improve sick sinus syndrome in aging mice through Nrf-2/HO-1 pathway: A new target for sick sinus syndrome.

J Ethnopharmacol 2021 Sep 29;277:114254. Epub 2021 May 29.

Liaoning University of Traditional Chinese Medicine, Shenyang, 110000, China; Department of Cardiology, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, 110000, China. Electronic address:

Ethnopharmacological Relevance: Yixin-Fumai granules (YXFMs)-composed of Ginseng quinquefolium (L.) Alph. Wood, Ophiopogon japonicus (Thunb. Read More

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September 2021

A Case of Hemodynamically Unstable Sick Sinus Syndrome Secondary to Refeeding Syndrome.

Cureus 2021 Apr 22;13(4):e14625. Epub 2021 Apr 22.

Internal Medicine, HCA Houston Healthcare West, Houston, USA.

Prolonged malnourished states can predispose patients to refeeding syndrome with the uncommon complication of cardiogenic shock if not corrected initially. While refeeding syndrome is well studied its complications may not be easily identified in the setting of rapid deterioration. This case report reviews the events of a 57-year-old male who was brought in by law enforcement, for altered mental status and agitation, after being found wandering in the woods. Read More

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A Novel pacing option in patients with endomyocardial fibrosis: A case series.

Indian Pacing Electrophysiol J 2021 May 24. Epub 2021 May 24.

Department of Cardiology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, Kerala, 695011, India.

Endomyocardial fibrosis (EMF) is characterized by fibrous tissue deposition on the endocardial surface leading to impaired filling of one or both ventricles, resulting in either right or left heart failure or both. Although Sinus node dysfunction and tachyarrhythmia - atrial fibrillation, ventricular tachycardia, have been commonly reported, complete heart block (CHB) necessitating a pacemaker is rare in EMF. Transvenous pacing is technically limited by fibrotic obliteration of the affected ventricle that results in poor lead parameters, and alternative pacing strategy like epicardial pacing may be required in many. Read More

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[The Pacemaker and Implantable Cardioverter-Defibrillator Registry of the Italian Association of Arrhythmology and Cardiac Pacing - Annual report 2019].

G Ital Cardiol (Rome) 2021 Jun;22(6):496-508

Dipartimento di Medicina Ambientale e Salute Pubblica, Università degli Studi, Padova.

Background: The pacemaker (PM) and implantable cardioverter-defibrillator (ICD) Registry of the Italian Association of Arrhythmology and Cardiac Pacing (AIAC) monitors the main epidemiological data in real-world practice. The survey for the 2019 activity collects information about demographics, clinical characteristics, main indications for PM/ICD therapy and device types from the Italian collaborating centers.

Methods: The Registry collects prospectively national PM and ICD implantation activity on the basis of European cards. Read More

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Sick Sinus Syndrome Can Be Associated with Postural Tachycardia Syndrome and Inappropriate Sinus Tachycardia Syndrome.

J Innov Card Rhythm Manag 2021 May 15;12(5):4526-4531. Epub 2021 May 15.

Division of Cardiovascular Medicine, Department of Medicine, University of Toledo, Toledo, OH, USA.

As a known phenomenon, crossover between sinus node dysfunction and common atrial tachyarrhythmias-most notably, atrial fibrillation and atrial flutter-in older individuals has previously been seen. Here, we present one of the first case series demonstrating a similar relationship between sinus node dysfunction and much rarer etiologies of tachyarrhythmia-that is, postural tachycardia syndrome and inappropriate sinus tachycardia. The exact pathological mechanisms behind these arrhythmias as well as the observation of concurrent nodal dysfunction are poorly understood. Read More

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Case Reports: Emery-Dreifuss Muscular Dystrophy Presenting as a Heart Rhythm Disorders in Children.

Front Cardiovasc Med 2021 7;8:668231. Epub 2021 May 7.

World-Class Research Centre for Personalized Medicine, Almazov National Medical Research Centre, Saint Petersburg, Russia.

Emery-Dreifuss muscular dystrophy (EDMD) is inherited muscle dystrophy often accompanied by cardiac abnormalities in the form of supraventricular arrhythmias, conduction defects and sinus node dysfunction. Cardiac phenotype typically arises years after skeletal muscle presentation, though, could be severe and life-threatening. The defined clinical manifestation with joint contractures, progressive muscle weakness and atrophy, as well as cardiac symptoms are observed by the third decade of life. Read More

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Further insights into the molecular complexity of the human sinus node - The role of 'novel' transcription factors and microRNAs.

Prog Biophys Mol Biol 2021 May 15. Epub 2021 May 15.

The Division of Cardiovascular Sciences, University of Manchester, United Kingdom; Department of Anatomy, Jagiellonian University Medical College, Krakow, Poland. Electronic address:

Research Purpose: The sinus node (SN) is the heart's primary pacemaker. Key ion channels (mainly the funny channel, HCN4) and Ca-handling proteins in the SN are responsible for its function. Transcription factors (TFs) regulate gene expression through inhibition or activation and microRNAs (miRs) do this through inhibition. Read More

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Sinus bradycardia with haemodynamic compromise following lithium intoxication.

BMJ Case Rep 2021 May 13;14(5). Epub 2021 May 13.

Department of Cardiovascular Medicine, University of Florida College of Medicine, Gainesville, Florida, USA.

Lithium is a well-established treatment for mood disorders and considered first-line pharmacological therapy for bipolar disorder as per the American Psychiatric Association guidelines. However, lithium is associated with significant toxicity. Cardiotoxicity including sinus node dysfunction is a rare but clinically significant presentation of lithium intoxication. Read More

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[Diffuse large B-cell lymphoma with mediastinal bulky mass associated with complication of repeated sinus arrest].

Rinsho Ketsueki 2021 ;62(4):262-266

Department of Internal Medicine, Kohsei Chuo General Hospital.

A 71-year-old woman presented to a clinic with the chief complaint of facial edema and dyspnea; chest radiography showed mediastinal mass shadow and right pleural effusion. Computed tomography guided biopsy of the mediastinal mass had been performed by her previous doctor, and she was diagnosed with diffuse large B-cell lymphoma. She was referred to our hospital for chemotherapy. Read More

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Utility of Surveillance Ambulatory Rhythm Monitoring in the Pediatric Fontan Population.

Pediatr Cardiol 2021 May 7. Epub 2021 May 7.

Division of Cardiology, Children's Hospital Los Angeles, 4650 Sunset Blvd, MS #34, Los Angeles, CA, 90049, USA.

Our institution established a Fontan surveillance plan, which included ambulatory rhythm monitoring (ARM) at 6, 10, 13, 16 and 19 years old, for early detection of Fontan-associated complications. We conducted a retrospective chart review of Fontan patients followed at our institution 2014-2018 to determine the utility of surveillance ARMs. 139 ARMs from 83 patients were included. Read More

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You cannot ablate the Lernaean Hydra: SCN5A mutation in a patient with multifocal ectopic Purkinje-related premature contractions syndrome treated with Flecainide and an implant of a subcutaneous defibrillator-a case report.

Eur Heart J Case Rep 2021 Apr 30;5(4):ytab158. Epub 2021 Apr 30.

University Hospital of Patras, Rio, Patras, 26504, Greece.

Background: SCN5A mutations may present with different clinical phenotypes such as Brugada syndrome, long QT3 syndrome, sick sinus syndrome, atrial fibrillation, dilated cardiomyopathy, and the least known multifocal ectopic Purkinje-related premature contractions syndrome.

Case Summary: We report a case of a 29-year-old woman with palpitations due to multifocal premature ventricular complexes (PVCs) and a family history of sudden death. The previous electrophysiological study had shown that PVCs arose from Purkinje fibres but catheter ablation was unsuccessful. Read More

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A novel familial SCN5A exon 20 deletion is associated with a heterogeneous phenotype.

J Electrocardiol 2021 May-Jun;66:131-135. Epub 2021 Apr 23.

Center for Arrhythmia Care, Heart & Vascular Center, Pritzker School of Medicine of the University of Chicago, Chicago, IL, USA.

The SCN5A gene, located on chromosome 3p21, has 28 exons and is a member of the human voltage-gated sodium channel gene family. Genetic variation in SCN5A is associated with a diverse range of phenotypes. Due to incomplete penetrance, delayed expression, inherent low signal-to-noise ratio, and marked phenotypic heterogeneity, rare novel variants in SCN5A could be misinterpreted. Read More

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Impact of corrected sinus node recovery time in predicting recurrence in patients with paroxysmal atrial fibrillation.

J Int Med Res 2021 May;49(5):3000605211010103

Department of Cardiology, Tongji Hospital Affiliated to 12476Tongji University, Shanghai, China.

Objective: Atrial fibrillation (AF) and sinus node dysfunction (SND) have common underlying pathophysiological mechanisms. As an index of SND, corrected sinus node recovery time (CSNRT) may also reflect atrial function. The aim of the present study was to determine whether CSNRT predicts AF recurrence in patients undergoing AF ablation. Read More

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Sinus node dysfunction - A well-defined entity?

Brian Olshansky

Int J Cardiol 2021 Jul 30;335:55-56. Epub 2021 Apr 30.

University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52242, USA. Electronic address:

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Prehospital Sinus Node Dysfunction and Asystole in a Previously Healthy Patient with COVID-19.

Prehosp Emerg Care 2021 Jun 7:1-5. Epub 2021 Jun 7.

We report a case of a previously healthy 47-year-old female with syncope due to multiple episodes of nodal dysfunction and asystole. During these brief episodes, she was hypoxic in the mid-80's as a result of COVID-19 pneumonia. The patient was admitted and treated for viral pneumonia and found to have normal electrocardiograms (ECG's), normal troponin levels and a normal echocardiogram during her hospital stay. Read More

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Delivery of a Leadless Transcatheter Pacing System as First-line Therapy in a 28-kg Pediatric Patient Through Proximal Right Internal Jugular Surgical Cutdown.

J Innov Card Rhythm Manag 2021 Apr 15;12(4):4482-4486. Epub 2021 Apr 15.

Division of Pediatric Cardiology, Penn State Health Children's Hospital, Hershey, PA, USA.

The Micra™ transcatheter pacing system (TPS) (Medtronic, Minneapolis, MN, USA) is the only leadless pacemaker currently approved by the United States Food and Drug Administration. A limitation to the use of this device in the pediatric population is the large size of the delivery sheath. We present a 28-kg, nine-year-old male with symptomatic asystolic pauses who underwent successful placement of a Micra™ TPS via right internal jugular vein surgical cutdown as a first-line option. Read More

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Shenxian-Shengmai Oral Liquid Improves Sinoatrial Node Dysfunction through the PKC/NOX-2 Signaling Pathway.

Evid Based Complement Alternat Med 2021 10;2021:5572140. Epub 2021 Apr 10.

Department of Cardiology, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, China.

Sick sinus syndrome (SSS) is one of the common causes of cardiac syncope and sudden death; the occurrence of SSS is associated with the accumulation of ROS in the sinoatrial node (SAN). Shenxian-shengmai (SXSM) is a traditional Chinese medicine available as oral liquid that causes a significant increase in heart rate. The objective of this study is to observe the improvement of SXSM on SAN function in SSS mice and explore its potential mechanism. Read More

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Self-Similar Synchronization of Calcium and Membrane Potential Transitions During Action Potential Cycles Predict Heart Rate Across Species.

JACC Clin Electrophysiol 2021 Apr 21. Epub 2021 Apr 21.

Laboratory of Cardiovascular Science, National Institute on Aging, National Institute of Health, Baltimore, Maryland, USA. Electronic address:

Objectives: The purpose of this study was to discover regulatory universal mechanisms of normal automaticity in sinoatrial nodal (SAN) pacemaker cells that are self-similar across species.

Background: Translation of knowledge of SAN automaticity gleaned from animal studies to human dysrhythmias (e.g. Read More

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