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Trans R Soc Trop Med Hyg 2021 May 4. Epub 2021 May 4.

Department of Medicine, Faculty of Medicine, University of Peradeniya, Sri Lanka.

Background: Hump-nosed vipers of the genus Hypnale are the most common cause of venomous snakebites in Sri Lanka. The genus includes three species: Hypnale hypnale, Hypnale zara and Hypnale nepa. Of them, H. Read More

Am J Med Sci 2020 Nov 26. Epub 2020 Nov 26.

Department of Hematopathology, the First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Yuzhong, Chongqing 400016, China. Electronic address:

Prehosp Emerg Care 2021 May 3:1-4. Epub 2021 May 3.

Montgomery County Hospital District, EMS, Conroe, 77304 United States.

We report a case of a previously healthy 47-year-old female with syncope due to multiple episodes of nodal dysfunction and asystole. During these brief episodes, she was hypoxic in the mid-80's as a result of COVID-19 pneumonia. The patient was admitted and treated for viral pneumonia and found to have normal electrocardiograms (ECG's), normal troponin levels and a normal echocardiogram during her hospital stay. Read More

PLoS One 2021 29;16(4):e0249997. Epub 2021 Apr 29.

School of Health, Fujian Medical University, Fuzhou, Fujian Province, China.

Second-generation antipsychotics (SGAs) play a critical role in current treatment of schizophrenia (SCZ). It has been observed that sinus bradycardia, rare but in certain situations life threatening adverse drug reaction, can be induced by SGAs across different schizophrenia populations. However, the roles of genetic factors in this phenomenon have not been studied yet. Read More

Endocrinol Diabetes Metab Case Rep 2021 Apr 1;2021. Epub 2021 Apr 1.

Department of Diabetes and EndocrinologyDarent Valley Hospital, Dartford, UK.

Summary: A phaeochromocytoma is a rare neuroendocrine tumour derived from the chromaffin cells of the adrenal medulla. Tumours can produce excessive amounts of catecholamines. The presenting symptoms can vary but often include the classic triad of episodic headaches, sweating and palpitations. Read More

BMJ Case Rep 2021 Apr 28;14(4). Epub 2021 Apr 28.

Department of Emergency Medicine, Catharina Hospital Eindhoven, Eindhoven, Netherlands.

A 52-year-old man with a history of urolithiasis presents to the emergency department with a sudden, sharp, continuous right flank colicky pain. Laboratory workup demonstrates acute kidney injury with a mild hyperkalaemia. During the observation period, the patient develops an atypical broad complex sinus bradycardia and eventually short asystolic periods. Read More

Front Pharmacol 2021 8;12:596956. Epub 2021 Apr 8.

Emergency Institute for Cardiovascular Diseases and Transplantation Târgu Mureş, Târgu Mureş, Romania.

The complex interactions that exist between the pacemaker current, , and the parasympathetic nervous system could significantly influence the course of patients undergoing chronic therapy with the blocker ivabradine. We thus aimed to assess the effects of chronic ivabradine therapy on autonomic modulation and on the cardiovascular response to and parasympathetic stimulation. The right atrial expression of HCN genes, encoding proteins for , was also evaluated. Read More

Arch Cardiol Mex 2021 ;91(2):186-189

Department of Endocrinology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México, México.

Objective: The objective of this study was to describe the case of a 19-year-old male presenting with bradycardia and hypotension after a honeybee sting making a review of the literature and pathophysiology of the cardiovascular and electrocardiogram (EKG) changes after a bee sting.

Methods: The patient's airway was inspected and secured. Electrocardiogram with an idioventricular rhythm at 41' bpm. Read More

BMC Sports Sci Med Rehabil 2021 Apr 20;13(1):41. Epub 2021 Apr 20.

Zhejiang Sino-German Institute of Life science and Healthcare, School of Biological and Chemical Engineering, Zhejiang University of Science and Technology, Hangzhou, China.

Background: The 12-lead electrocardiogram (ECG) has been adopted as an important component of preparticipation cardiovascular screening. However, there are still controversies in the screening and few studies with a large sample size have reported the results of ECGs of marathon runners. Therefore, the purpose of this study was to assess the prevalence of normal, borderline, and abnormal ECG changes in marathon runners. Read More

Front Genet 2021 1;12:654925. Epub 2021 Apr 1.

Frick Center for Heart Failure and Arrhythmia Research, The Ohio State University Wexner Medical Center, Columbus, OH, United States.

The pacemaker cells of the cardiac sinoatrial node (SAN) are essential for normal cardiac automaticity. Dysfunction in cardiac pacemaking results in human sinoatrial node dysfunction (SND). SND more generally occurs in the elderly population and is associated with impaired pacemaker function causing abnormal heart rhythm. Read More

J Interv Cardiol 2021 30;2021:8810484. Epub 2021 Mar 30.

Heart Institute, Emek Medical Center, Afula, Israel.

Background: Sinus node artery occlusion (SNO) is a rare complication of percutaneous coronary intervention (PCI). We analyze both the short- and long-term consequences of SNO.

Methods: We retrospectively reviewed 1379 consecutive PCI's involving RCA and Cx arteries performed in our heart institute from 2016 to 2019. Read More

BMJ Case Rep 2021 Apr 13;14(4). Epub 2021 Apr 13.

Internal Medicine, Baby Memorial Hospital, Calicut, Kerala, India.

Scrub typhus is an acute febrile disease transmitted via bites from mite larvae (chigger) infected with Orientia tsutsugamushi. Arrhythmias, ischaemic changes and QT prolongation are some of the observed ECG abnormalities. The patient being reported presented with angina and was found to have sinus bradycardia with ST elevation in inferior leads and T wave inversion in lateral leads. Read More

Front Cardiovasc Med 2021 23;8:630399. Epub 2021 Mar 23.

Department of Cardiology, The Second Affiliate Hospital of Xi'an Jiaotong University, Xi'an, China.

Cardiac pacing is an effective therapy for treating patients with bradycardia due to sinus node dysfunction or atrioventricular block. However, traditional right ventricular apical pacing (RVAP) causes electric and mechanical dyssynchrony, which is associated with increased risk for atrial arrhythmias and heart failure. Therefore, there is a need to develop a physiological pacing approach that activates the normal cardiac conduction and provides synchronized contraction of ventricles. Read More

Minerva Med 2021 Apr 9. Epub 2021 Apr 9.

Laboratory of Biochemistry, Timone Hospital and C2VN INSERM, INRAE, Aix Marseille University, Marseille, France.

Either central or peripheral baroreceptor reflex abnormalities and/or alterations in neurohumoral mechanisms play a pivotal role in the genesis of neurally mediated syncope. Thus, improving our knowledge of the biochemical mechanisms underlying specific forms of neurally mediated syncope (more properly termed 'neurohumoral syncope') might allow the development of new therapies that are effective in this specific subgroup. A low-adenosine phenotype of neurohumoral syncope has recently been identified. Read More

Herzschrittmacherther Elektrophysiol 2021 Apr 6. Epub 2021 Apr 6.

Klinik für Kinder- und Jugendmedizin, Pädiatrische Kardiologie, Intensivmedizin und Pneumologie, Kinderherzklinik/Überregionales EMAH-Zentrum, Universitätsmedizin Göttingen, Robert-Koch-Str. 40, 37075, Göttingen, Deutschland.

The normal fetal heart rate ranges between 110 und 180 beats per minute (bpm). Intrauterine arrhythmias are not an uncommon finding. Fetal echocardiography (ECG) allows for correct diagnosis of the arrhythmia, which is prerequisite for decision making and treatment. Read More

J Med Case Rep 2021 Apr 6;15(1):151. Epub 2021 Apr 6.

Department of Cardiology, NewYork-Presbyterian Queens, Flushing, USA.

Background: Pseudo-Wellens syndrome is a rare entity characterized by the presence of electrocardiogram (ECG) changes of Wellens syndrome but without the stenosis of the left anterior descending (LAD) coronary artery. In previous reports, pseudo-Wellens syndrome most commonly resulted from recreational drug use or unidentified etiologies. We present a unique case of pseudo-Wellens syndrome due to sepsis-induced cardiomyopathy and a review of the literature. Read More

Intern Med 2021 Apr 5. Epub 2021 Apr 5.

Department of Onco-Cardiology, Osaka International Cancer Institute, Japan.

Pazopanib, a multi-targeted tyrosine kinase inhibitor, is associated with cardiovascular adverse events, such as hypertension, cardiac dysfunction, and thromboembolism. However, symptomatic pazopanib-related bradycardia is uncommon. We herein report a case of symptomatic bradycardia of 35 beats per minute in a patient with solitary fibrous tumor/hemangiopericytoma (SFT/HPC) treated with pazopanib for 1 month. Read More

Rev Port Cardiol 2021 Mar 15. Epub 2021 Mar 15.

Hospital de S. Bernardo, Centro Hospitalar de Setúbal E.P.E., Setúbal, Portugal; Hospital da Luz, Lisbon, Portugal.

Introduction And Objectives: In December 2019, SARS-CoV-2, was discovered as the agent of COVID-19 disease. Cardiac arrhythmias have been reported as frequent but their incidence is unknown. The aim of this research was to assess the real incidence of cardiac arrhythmias among COVID-19 patients admitted to Portuguese hospitals and to understand the underlying prognostic implications. Read More

Int Med Case Rep J 2021 19;14:171-176. Epub 2021 Mar 19.

Cardiovascular Disease Center, Central Hospital of Tujia and Miao Autonomous Prefecture, Enshi Clinical College of Wuhan University, Enshi Prefecture, 445000, Hubei Province, People's Republic of China.

Background: Thyroxine is closely related to cardiovascular diseases, such as coronary heart disease, ventricular arrhythmia, atrioventricular block, myocardial systolic weakness, pericardial effusion, low cardiac output and hypertension. Previous studies have also found that hypothyroidism can also lead to mental disorders. Here, we present a rare case of severe hypothyroidism patient accompanied by sick sinus syndrome (SSS) as a cardiovascular manifestation needing cardiac pacing and severe mental disorders. Read More

Infect Dis (Lond) 2021 Mar 24:1-4. Epub 2021 Mar 24.

Department of Pediatric Infection, Dr. Cemil Tascioglu City Hospital, Istanbul, Turkey.

Background: Severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) has caused an infectious disease that affects multiple organs. Recently, the cardiological effects of the virus have also been striking. To the best of our knowledge, there are no SARS CoV-2 positive paediatric cases reported with sinus bradycardia in the literature. Read More

Cardiol Young 2021 Mar 22:1-3. Epub 2021 Mar 22.

Department of Pediatric Critical Care Medicine, INOVA Fairfax Children's Hospital, 3300 Gallows Road, Falls Church, VA22042, USA.

SARS-CoV-2, which causes the disease COVID-19, generally has a mild disease course in children. However, a severe post-infectious inflammatory process known as multisystem inflammatory syndrome in children has been observed in association with COVID-19. This inflammatory process is a result of an abnormal immune response with similar clinical features to Kawasaki disease. Read More

Ann Noninvasive Electrocardiol 2021 Mar 19:e12833. Epub 2021 Mar 19.

East Atlanta Cardiology, Decatur, GA, USA.

Background: Cardiovascular events have been reported in the setting of coronavirus disease-19 (COVID-19). It has been hypothesized that systemic inflammation may aggravate arrhythmias or trigger new-onset conduction abnormalities. However, the specific type and distribution of electrocardiographic disturbances in COVID-19 as well as their influence on mortality remain to be fully characterized. Read More

Rev Prat 2020 10;70(8):e271-e276

Unité de rythmologie, département de cardiologie, Hôpital européen Georges-Pompidou, Paris, France.

Am J Physiol Heart Circ Physiol 2021 05 19;320(5):H1873-H1886. Epub 2021 Mar 19.

Children's National Heart Institute, Children's National Hospital, Washington, District of Columbia.

Compared with acyanotic congenital heart disease (CHD), cyanotic CHD has an increased risk of lifelong mortality and morbidity. These adverse outcomes may be attributed to delayed cardiomyocyte maturation, since the transition from a hypoxic fetal milieu to oxygen-rich postnatal environment is disrupted. We established a rodent model to replicate hypoxic myocardial conditions spanning perinatal development, and tested the hypothesis that chronic hypoxia impairs cardiac development. Read More

Int Heart J 2021 Mar 17;62(2):298-304. Epub 2021 Mar 17.

Arrhythmia Center, Tokyo Medical and Dental University.

Radiofrequency and cryoballoon applications around the pulmonary veins (PVs) could provoke a vagal reflex (VR) by modulating the intrinsic cardiac autonomic nervous system (ICANS).This study aimed to investigate the incidence, timing, and clinical impact of a VR provoked by a laser balloon application for a PV isolation (PVI).A total of 92 consecutive paroxysmal atrial fibrillation (PAF) patients underwent a laser balloon PVI of PAF. Read More

Cureus 2021 Feb 11;13(2):e13274. Epub 2021 Feb 11.

Cardiology, National Institute of Cardiovascular Diseases, Karachi, PAK.

Background The aim of this study was to determine the in-hospital outcome of female patients with inferior wall myocardial infarction (MI). Methodology This study was conducted from January to December 2017 at the Department of Cardiology, National Institute of Cardiovascular Disease, Karachi. A total of 59 women admitted with inferior wall MI were enrolled in the study. Read More

Cureus 2021 Feb 10;13(2):e13262. Epub 2021 Feb 10.

Cardiac Arrhythmia Center, Cardiovascular Division, University of Minnesota, Minneapolis, USA.

Preeclampsia is a multifactorial pregnancy-specific syndrome, which can result in significant alterations in cardiovascular hemodynamics. We report an observation of unexpected relative bradycardia in a previously healthy woman who presented with postpartum preeclampsia and acute pulmonary edema. We observed an increase in heart rate following normalization of blood pressure, which suggested that the initial slower than expected heart rate may reflect a baroreceptor response to hypertension. Read More

Clin Neurol Neurosurg 2021 Apr 2;203:106589. Epub 2021 Mar 2.

Department of Neurosurgery, Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicine, Wonju, 26426, Republic of Korea. Electronic address:

Objective: Carotid artery stenting (CAS) is a major treatment option for carotid artery stenosis, and a recognized alternative to carotid endarterectomy (CEA). However, CAS-related hemodynamic instability occurs frequently and is a known major risk factor of associated complications. This study was undertaken to identify the risk factors of hemodynamic instability associated with CAS. Read More

Am J Case Rep 2021 Mar 10;22:e929573. Epub 2021 Mar 10.

Department of Cardiology, United Health Services Hospitals, Wilson Regional Medical Center, Johnson City, NY, USA.

BACKGROUND Myxedema coma is an endocrine emergency with a high mortality rate, defined as a severe hypothyroidism leading to hypotension, bradycardia, decreased mental status, hyponatremia, hypoglycemia, and cardiogenic shock. Although hypothyroidism and cardiac disease has been interlinked, ST elevation myocardial infarction in the setting of myxedema coma have not been reported previously. CASE REPORT We report the case of a 70-year-old man who presented to the Emergency Department with chest pain and confusion. Read More