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Open Heart 2019 25;6(1):e001015. Epub 2019 Mar 25.

Department of Clinical Sciences, Lund University, Malmö, Sweden.

Objective: Pacemaker (PM) therapy is effective when syncope is associated with bradycardia, but syncope recurrences and fall injuries after PM implantation may occur. We aimed to survey indications and outcomes of PM implantation, following evaluation of unexplained syncope.

Methods: Among 1666 consecutive unpaced patients investigated in a tertiary syncope unit by carotid-sinus massage (CSM), head-up tilt test (HUT) and ECG monitoring, 106 (6. Read More

J Cardiol 2019 Apr 11. Epub 2019 Apr 11.

Department of Cardiology, Asahi General Hospital, Asahi, Chiba, Japan.

Background: Currently, bradycardia treatment is limited to permanent pacemaker (PM) implantation. No consensus exists as to its optimal medication regimen. However, as cilostazol accelerates heart rate (HR) in bradycardia, we investigated its efficacy for sick sinus syndrome (SSS) to avoid permanent PM implantation. Read More

J Int Med Res 2019 Apr 10:300060519841156. Epub 2019 Apr 10.

1 Department of Cardiology, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, China.

Clinical doctors rarely associate hyperparathyroidism with significant bradyarrhythmia. We report a rare case of a patient initially misdiagnosed with primary sick sinus syndrome, which was eventually shown to be secondary to primary hyperparathyroidism. Read More

Front Physiol 2019 18;10:259. Epub 2019 Mar 18.

The William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.

The congenital long QT syndrome (LQTS) is a cardiac electrophysiological disorder that can cause sudden cardiac death. LQT1 is a subtype of LQTS caused by mutations in KCNQ1, affecting the slow delayed-rectifier potassium current (), which is essential for cardiac repolarization. Paradoxically, gain-of-function mutations in KCNQ1 have been reported to cause borderline QT prolongation, atrial fibrillation (AF), sinus bradycardia, and sudden death, however, the mechanisms are not well understood. Read More

Evid Based Complement Alternat Med 2019 4;2019:3917282. Epub 2019 Mar 4.

Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Pharmacological antiarrhythmic therapy such as beta-blockers in patients with frequent premature ventricular contractions (PVCs) and concomitant bradycardia is challenging. A traditional Chinese medicine, Shensong Yangxin (SSYX), has been effective in treatment of frequent PVCs and sinus bradycardia (SB) in separate patient cohorts. This double-blind, placebo-controlled, multicentre, randomized clinical trial investigates the acute efficacy of SSYX in reducing PVCs burden in patients with concomitant SB. Read More

Australas Phys Eng Sci Med 2019 Apr 2. Epub 2019 Apr 2.

University of Dschang, LISIE/L2MSP, P.O. Box 134, Bandjoun, Cameroon.

In this paper, synthetic electrocardiogram signals (SECG) of eight cardiac arrhythmias (sinus bradycardia, junctional bradycardia, tachycardia, flutter, atrial extrasystole, ventricular extrasystole, left branch block and right branch block) are obtained numerically by solving the McSharry mathematical model (2003) based on three coupled ordinary differential equations with the fourth-order Runge-Kutta method. They are compared with normal electrocardiogram signal. Indeed, visual analysis of a section of electrocardiogram (ECG) signals of these arrhythmias was used to suggest suitable values for the parameters in the McSharry mathematical model. Read More

G Ital Cardiol (Rome) 2019 Apr;20(4):242-253

U.O. Cardiologia, Ospedale P. Pederzoli, Peschiera del Garda (VR).

Athlete's heart, as a consequence of exercise training, is characterized by hypervagotonia and enlargement of cardiac chambers. Such modifications influence the electrocardiogram. In fact, athletes frequently present with common cardiac alterations, including sinus bradycardia, first and second degree atrioventricular block, increased QRS voltage, and early repolarization. Read More

Pediatr Cardiol 2019 Apr 27;40(4):685-693. Epub 2019 Mar 27.

Department of Clinical Sciences, Pediatrics, Umeå University, 901 85, Umeå, Sweden.

Sinus node dysfunction (SND) causes significant morbidity in patients after Fontan surgery. Heart rate variability (HRV) reflects the autonomic regulation of the heart, and changes in HRV have been associated with SND in adults. We aimed to study whether changes in HRV could be detected in 24-h electrocardiographic (ECG) recordings in Fontan patients with SND. Read More

Cureus 2019 Jan 12;11(1):e3871. Epub 2019 Jan 12.

Anesthesiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, USA.

In this case report, we present a patient who developed anaphylaxis immediately after sugammadex administration. A 67-year-old female with the diagnosis of papillary serous carcinoma was scheduled for an exploratory laparotomy exam under anesthesia and total abdominal hysterectomy. At the end of the operation, sugammadex was administered; it was rapidly accompanied with marked hypotension and bradycardia. Read More

Clin J Sport Med 2019 Mar 8. Epub 2019 Mar 8.

Department of Cardiovascular, Neural and Metabolic Sciences, Istituto Auxologico Italiano, IRCCS, San Luca Hospital, Milan, Italy.

Absence of the pericardium is a rare congenital disease in which the fibroserum membrane covering the heart is partially or totally absent. It is characterized by few echocardiography (ECG) and imaging features that can mislead the diagnosis to an inherited cardiac disease, such as arrhythmogenic right ventricular cardiomyopathy. Although it has often a benign course, this congenital defect should be identified as in some cases herniation and strangulation can be life-threatening and cause sudden cardiac death. Read More

Epilepsy Behav 2019 Mar 15;94:59-64. Epub 2019 Mar 15.

Department of Neurology and Clinical Neurophysiology, St. Olav's University Hospital, Trondheim, Norway; Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.

Purpose: Juvenile neuronal ceroid lipofuscinosis (CLN3 disease) is the most common neurodegenerative disorder in childhood with survival until young adult age. Visual loss is followed by epilepsy, cognitive, neuropsychiatric, and motor symptoms. We have studied the evolution of electroencephalographic (EEG) and seizure characteristics. Read More

Am J Ther 2019 Mar 14. Epub 2019 Mar 14.

Department of Medicine, St. Vincent's Medical Center, Bridgeport, CT.

Medicine (Baltimore) 2019 Mar;98(11):e14826

OrigiMed, Shanghai.

Rationale: The anaplastic lymphoma kinase (ALK) rearrangements represent a subtype of nonsmall-cell lung cancer (NSCLC), and targeting ALK has radically changed the treatment of NSCLC. Crizotinib, as an ALK inhibitor, has been used in the treatment of ALK-rearranged NSCLC for several years and some adverse effects should be given attention.

Patient Concerns: A 64-year-old woman with a no-smoking history visited hospital in November 2016 because of a persistent cough, expectoration, and progressive dysphagia for 2 months. Read More

Rev Port Cardiol 2019 Feb 15;38(2):105-111. Epub 2019 Mar 15.

Serviço de Cardiologia, Centro Hospitalar de Setúbal, Setúbal, Portugal.

Introduction: In iatrogenic or potentially reversible bradyarrhythmia, drug discontinuation or metabolic correction is recommended before permanent cardiac pacemaker (PM) implantation. These patients often have conduction system disease and there are few data on recurrence or the need for a permanent PM.

Objective: To analyze the need for PM implantation in patients with iatrogenic bradyarrhythmia or bradyarrhythmia associated with other potentially reversible causes. Read More

Rev Prat 2018 Apr;68(4):407

Dispositif de toxicovigilance Antilles, centre hospitalier de Basse-Terre, Basse-Terre, Guadeloupe, France.

Cureus 2019 Jan 3;11(1):e3821. Epub 2019 Jan 3.

Internal Medicine, Detroit Medical Center - Wayne State University, Detroit, USA.

Cardiac arrhythmias were reported in cases of West Nile Virus (WNV) encephalitis; however, the underlying pathophysiology remains incompletely understood. We present a 67-year-old male with altered mental status, later diagnosed with WNV encephalitis. Hospital course was complicated by progressive sinus bradycardia and corrected QT (QTc) prolongation. Read More

J Int Med Res 2019 Mar 5:300060519833293. Epub 2019 Mar 5.

2 Department of Gastroenterology, The First Affiliated Hospital, Sun Yet-sen University, Guangzhou, People's Republic of China.

Thalidomide is effective in inducing and maintaining clinical remission, as well as mucosal healing, in patients with refractory Crohn's disease (CD). However, long-term use of thalidomide has raised concern because of the high incidence of adverse events. Cardiovascular events induced by thalidomide have been reported in patients with multiple myeloma, amyotrophic lateral sclerosis, and transfusion-dependent refractory anemia. Read More

Clin Med Insights Case Rep 2019 25;12:1179547619831026. Epub 2019 Feb 25.

Department of Neurological and Psychiatric sciences (NEUROFARBA), University of Florence, Florence, Italy.

High dose corticosteroid therapy is widely used as attack therapy of inflammatory central nervous system disorders and can induce several adverse reactions. Bradycardia is an infrequent event after corticosteroids administration and is often asymptomatic. We report a case of a woman admitted to the neurological department of our hospital for paraesthesias of the lower limbs. Read More

G Ital Cardiol (Rome) 2019 Mar;20(3):136-148

Dipartimento di Medicina Ambientale e Salute Pubblica, Università degli Studi, Padova.

Background: The pacemaker (PM) and implantable cardioverter-defibrillator (ICD) Registry of the Italian Association of Arrhythmology and Cardiac Pacing (AIAC) monitors the main epidemiological data in real-world practice. The survey for the 2017 activity collects information about demographics, clinical characteristics, main indications for PM/ICD therapy and device types from the Italian collaborating centers.

Methods: The Registry collects prospectively national PM and ICD implantation activity on the basis of European cards. Read More

Indian Pacing Electrophysiol J 2019 Feb 25. Epub 2019 Feb 25.

Department of Pediatrics, Oregon Health & Science University, Portland, OR, USA.

This article reviews important features for improving the diagnosis and management of fetal arrhythmias. The normal fetal heart rate ranges between 110 and 160 beats per minute. A fetal heart rate is considered abnormal if the heart rate is beyond the normal ranges or the rhythm is irregular. Read More

Rinsho Shinkeigaku 2019 Mar 28;59(3):149-152. Epub 2019 Feb 28.

Department of Internal Medicine, Imari Arita Kyoritsu Hospital.

A 73-year-old woman with Parkinson disease (PD) was admitted to our hospital because of aspiration pneumonia. She presented with recurrent episodes of loss of consciousness with bradycardia while swallowing solid foods or fluids. Upper endoscopy revealed a normal esophagus without hiatus hernia, cancer, diverticulum, stenosis, or achalasia. Read More

J Arrhythm 2019 Feb 1;35(1):139-141. Epub 2018 Nov 1.

Cardiac Health Heart Centred and Cardiology Division Department of Medicine Queen Mary Hospital The University of Hong Kong Hong Kong China.

Atrioventricular nodal (AVN) ablation and right ventricular (RV) pacing is recommended for refractory atrial fibrillation (AF) and tachycardia-bradycardia syndrome. Three AF patients (mean age 83, range 79-89 years) underwent AVN ablation and transvenous leadless pacemaker Micra implantations using the same venous access without anticoagulation interruption. Satisfactory pacing 0. Read More

BMJ Case Rep 2019 Feb 22;12(2). Epub 2019 Feb 22.

Cardiology, Albany Medical Center Hospital, Albany, New York, USA.

We present a case of sinus arrest and junctional escape rhythm from sinus node artery (SNA) thrombus in a 55-year-old man after revascularisation of right coronary and proximal circumflex arteries for infero-posterior wall ST-segement elevation myocardial infarction (STEMI). Sinus arrest from occlusion of the SNA is uncommon. The ensuing bradycardia may have haemodynamic consequences requiring temporary pacing but is almost always self-limited. Read More

Hemodial Int 2019 Apr 18;23(2):E65-E68. Epub 2019 Feb 18.

Department of Medicine, Division of Nephrology, State University of New York (SUNY) Upstate Medical University, Syracuse, New York.

Sudden cardiac death (SCD) is reported as leading cause of death in patients on chronic hemodialysis. Arrhythmias are proposed to be a major predisposing factor for SCD. However, triggers for potentially lethal arrhythmias are not well understood. Read More

Clin Res Cardiol 2019 Feb 15. Epub 2019 Feb 15.

Semmelweis University Heart and Vascular Centre, Városmajor u. 68, Budapest, 1122, Hungary.

Objective: Patients with electrical injury are considered to be at high risk of cardiac arrhythmias. Due to the small number of studies, there is no widely accepted guideline regarding the risk assessment and management of arrhythmic complications after electrical accident (EA). Our retrospective observational study was designed to determine the prevalence of ECG abnormalities and cardiac arrhythmias after EA, to evaluate the predictive value of cardiac biomarkers for this condition and to assess in-hospital and 30-day mortality. Read More

Pediatrics 2019 Mar 12;143(3). Epub 2019 Feb 12.

Divisions of Emergency Medicine and.

A 2-year-old girl with a past medical history of cutaneous mastocytosis and eczema presented with 1 day of yellow-green, nonbloody vomiting, bradycardia, and listlessness. She was evaluated by her pediatrician and sent to the emergency department because of concern for dehydration. In the emergency department, she improved with fluid rehydration but still had decreased energy and bradycardia. Read More

J Tehran Heart Cent 2018 Jul;13(3):136-139

Department of Cardiothoracic Surgery, Barts Heart Centre, St Bartholomew's Hospital, London, UK.

Intraventricular conduction abnormalities following cardiac surgery have been thoroughly described, especially after valvular surgery. It is also widely known that several anesthetic factors can cause autonomic disturbances resulting in the unmasking of sinus node dysfunction, significant bradycardia, and cardiovascular collapse during the intraoperative period. However, little is known about asymptomatic episodes, especially those occurring prior to coronary artery bypass grafting (CABG). Read More

Best Pract Res Clin Obstet Gynaecol 2019 Jan 9. Epub 2019 Jan 9.

Royal Brompton and Harefield NHS Foundation Trust, Sydney Street, London, SW3 6NP, UK; Fetal Medicine Unit, St George's University Hospital, Blackshaw Road, London, SW17 0QT, UK; Molecular and Clinical Sciences Research Institute, St George's, University of London, Cranmer Terrace, London, SW17 0RE, UK. Electronic address:

Fetal dysrhythmias are common abnormalities, usually manifesting as irregular rhythms. Although most irregularities are benign and caused by isolated atrial ectopics, in a few cases, rhythm irregularity may indicate partial atrioventricular block, which has different etiological and prognostic implications. We provide a flowchart for the initial management of irregular rhythm to help select cases requiring urgent specialist referral. Read More

J Vet Cardiol 2019 Apr 29;22:20-39. Epub 2019 Jan 29.

Clinica Veterinaria Malpensa, Viale Marconi 27, 21017 Samarate, Varese, Italy.

Pacemaker implantation is considered as a standard procedure for treatment of symptomatic bradycardia in both dogs and cats. Advanced second-degree and third-degree atrioventricular blocks, sick sinus syndrome, persistent atrial standstill, and vasovagal syncope are the most common rhythm disturbances that require pacing to either alleviate clinical signs or prolong survival. Most pacemakers are implanted transvenously, using endocardial leads, but rarely epicardial leads may be necessary. Read More

BMJ Case Rep 2019 Jan 29;12(1). Epub 2019 Jan 29.

Department of Paediatrics, Barking Havering and Redbridge University Hospitals NHS Trust, Romford, UK.

We report a case of a 10-day-old male infant who presented to the emergency department with severe electrolyte imbalance and life-threatening arrhythmia. The parents reported a 3-day history of poor feeding and lethargy. On examination, he was bradycardic (heart rate of 65 beats/min) with signs of dehydration. Read More

Pacing Clin Electrophysiol 2019 Mar 12;42(3):381-387. Epub 2019 Feb 12.

Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium.

Introduction: The MARVEL study demonstrated at a single time point that accelerometer (ACC)-based atrial sensing improves atrioventricular (AV) synchrony (AVS) in patients with AV block and a Micra pacemaker (Medtronic, Minneapolis, MN, USA). The purpose of the MARVEL Evolve substudy was to assess the performance over time.

Methods: This prospective single-center study compared AVS and ACC signals at two visits ≥6 months apart. Read More

Ann Cardiol Angeiol (Paris) 2019 Feb 23;68(1):17-21. Epub 2019 Jan 23.

Unité de formation et de recherche en sciences de la santé, université de Ouagadougou, Ouagadougou, Burkina Faso.

Purpose Of The Study: To describe the clinical, electrocardiographic and echocardiographic features of the athlete's heart.

Patients And Methods: This was a cross-sectional study conducted from August 2015 to February 2016 in the city of Bobo-Dioulasso in Burkina Faso. Athletes of high level of training (at least 8hours of weekly training, for more than six months regardless of the type of sport) have benefited from: a clinical examination, an electrocardiography and a cardiac ultrasound rest to look for electrical, morphological and functional cardiac changes. Read More

Radiology 2019 Feb;290(2):569-573

From the Department of Radiology and Medical Imaging (A.H.S., M.S.R., J.R.D.) and Division of Cardiology (R.A.M.), Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229.

History A 17-year-old white male adolescent was re-evaluated for a withheld cardiac condition initially detected during prenatal imaging at an outside institution. He had previously experienced intermittent episodes of shortness of breath, chest pain, and palpitations with exertion, but more recently he had been asymptomatic. He had no other comorbidities and no family history of congenital heart disease, cardiomyopathy, arrhythmia, or sudden cardiac death. Read More

Circ Genom Precis Med 2019 Jan;12(1):e002238

Department of Cardiovascular Medicine, Institute for Genetics of Heart Diseases (IfGH), University Hospital Münster, Germany (J.K., B.S., S.Z., G.S., E.S.-B.).

Background: Inherited forms of sinus node dysfunction (SND) clinically include bradycardia, sinus arrest, and chronotropic incompetence and may serve as disease models to understand sinus node physiology and impulse generation. Recently, a gain-of-function mutation in the G-protein gene GNB2 led to enhanced activation of the GIRK (G-protein activated inwardly rectifying K channel). Thus, human cardiac GIRK channels are important for heart rate regulation and subsequently, genes encoding their subunits Kir3. Read More

Phys Sportsmed 2019 Jan 14:1-4. Epub 2019 Jan 14.

c Department of Cardiology , Hopital Pontchaillou Service de medecine du sport , Rennes , France.

It is established that an intensive training results in a lower average resting heart rate. Management of bradycardia in an athlete can be difficult given the underlying mechanisms are not clearly understood. The authors reviewed the different mechanisms described in the literature, including recent advances in physiology regarding remodeling of ion channels, which may partially explain bradycardia in athletes. Read More

Curr Health Sci J 2018 Jan-Mar;44(1):29-33. Epub 2018 Mar 28.

Department of Physiology, University of Medicine and Pharmacy of Craiova, Romania.

Objectives: To assess gender differences in training-related electrocardiographic (ECG) patterns of athletes, highlighting the importance of these differences for ECG interpretation used in the cardiovascular screening of athletes.

Design: Observational cross-sectional study.

Methods: 315 athletes were enrolled in the study (150 males and 165 females, mean age 23,7±6,6 and 20,7±6,8, respectively). Read More

Front Physiol 2018 18;9:1795. Epub 2018 Dec 18.

Department of Medical Biology, Amsterdam University Medical Centers, Amsterdam, Netherlands.

Carriers of the E161K mutation in the gene, encoding the Na1.5 pore-forming α-subunit of the ion channel carrying the fast sodium current (I), show sinus bradycardia and occasional exit block. Voltage clamp experiments in mammalian expression systems revealed a mutation-induced 2. Read More

Ann Noninvasive Electrocardiol 2019 May 7;24(3):e12623. Epub 2019 Jan 7.

Department of Cardiovascular Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan.

Background: RYR2, encoding cardiac ryanodine receptor, is the major responsible gene for catecholaminergic polymorphic ventricular tachycardia (CPVT). Meanwhile, KCNJ2, encoding inward-rectifier potassium channel (I ), can be the responsible gene for atypical CPVT. We recently encountered a family with CPVT and sought to identify a responsible gene variant. Read More

Clin Pract 2018 Oct 28;8(4):1094. Epub 2018 Nov 28.

College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.

In recent years, influenza infection in the pediatric population has been a widescale issue that physicians face during the winter season. Medications used to treat and prevent such infections include Oseltamivir, an anti-viral neuraminidase inhibitor developed for both influenzas A and B. The most commonly well-known and manifesting adverse effects are nausea, vomiting and gastrointestinal upset. Read More

Circulation 2018 Nov 6:CIR0000000000000628. Epub 2018 Nov 6.

Circulation 2018 Nov 6:CIR0000000000000627. Epub 2018 Nov 6.

Clin Case Rep 2018 Dec 30;6(12):2445-2450. Epub 2018 Oct 30.

Cardiology Centre Hospitalier Universitaire Dinant/Godinne Yvoir Belgium.

Sick sinus syndrome is uncommon in children, and syndromic forms are rare. Some forms of sick sinus syndrome like the bradycardia-tachycardia type could be managed by a radiofrequency ablation, even in young children, and could be helpful to delay the implantation of a pacemaker. Read More

J Vet Cardiol 2019 Apr 14;22:2-19. Epub 2018 Dec 14.

Department of Physiology and Cell Biology, Dorothy M. Davis Heart & Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH, USA. Electronic address:

The sinoatrial node (SAN) is the primary pacemaker in canine and human hearts. The SAN in both species has a unique three-dimensional heterogeneous structure characterized by small pacemaker myocytes enmeshed within fibrotic strands, which partially insulate the cells from aberrant atrial activation. The SAN pacemaker tissue expresses a unique signature of proteins and receptors that mediate SAN automaticity, ion channel currents, and cell-to-cell communication, which are predominantly similar in both species. Read More

Medicine (Baltimore) 2018 Dec;97(50):e13629

Department of Neurology, The Second Hospital of Jilin University, Changchun, China.

Rationale: Co-occurrence of headache and arrhythmia is not rare. However, their causal relationship remains unclear. Here, we described a case of migraine-like headache relieving with pacemaker implantation. Read More

Heart Rhythm 2018 Dec 11. Epub 2018 Dec 11.

University Hospital Rangueil, Toulouse, France; Unité Inserm U 1048, Toulouse, France. Electronic address:

Background: The relationships between hemodynamic consequences of premature ventricular contractions (PVCs) and development of premature ventricular contraction-induced cardiomyopathy (PVC-CM) have not been investigated.

Objective: The purpose of this study was to correlate concealed mechanical bradycardia and/or postextrasystolic potentiation (PEP) to PVC-CM.

Methods: Invasive arterial pressure measurements from 17 patients with PVC-CM and 16 controls with frequent PVCs were retrospectively analyzed. Read More

Am J Cardiol 2019 Mar 4;123(5):833-838. Epub 2018 Dec 4.

Serviço de Cardiologia e Cirurgia Cardiovascular e Centro de Telessaúde do Hospital das Clínicas da UFMG, Belo Horizonte, Minas Gerais, Brazil; Departamento de Clínica Médica, Faculdade de Medicina da Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil. Electronic address:

Incidence of Yellow Fever (YF) has increased in Brazil, and cardiac findings such as bradyarrhythmias and conduction abnormalities have been described. We aimed to perform a comprehensive cardiac evaluation of patients with YF, and to assess the association between cardiac involvement and disease severity. Patients hospitalized with YF from February to March 2018 underwent clinical and laboratory evaluation, focused bedside echocardiography (GE Vivid IQ), electrocardiogram and, in case of alterations, 24-hours Holter. Read More

Medicine (Baltimore) 2018 Dec;97(49):e13561

Department of Cardiology.

Rationale: The lambda-like ST-elevation electrocardiography (ECG) pattern is extremely rare in patients with type 2 myocardial infarction (T2MI) triggered by coronary spasm. When this ECG pattern appears, sudden cardiac death (SCD) caused by lethal ventricular arrhythmia may occur because clinicians do not pay sufficient attention to this phenomenon.

Patient Concerns: We describe a 41-year-old man who presented with steep down-sloping ST-segment elevation, paroxysmal ventricular tachycardia, severe sinus bradycardia, and intermittent complete atrioventricular block on ECG during the sudden recurrence of clinical symptoms. Read More

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2018 Nov;30(11):1046-1050

Department of Pediatrics, the First Affiliated Hospital of Bengbu Medical College, Bengbu 233004, Anhui, China (Chen X, Peng WS, Zhang Z, Zhao Q, Zhou Y, Chen L); Department of Pediatric, Anhui Provincial Hospital, the First Affiliated Hospital of University of Science and Technology of China, Hefei 230001, Anhui, China (Pan JH). Corresponding author: Pan Jiahua, Email:

Objective: To evaluate the efficacy and safety of selective brain hypothermia (SBH) in the treatment of neonates with moderate or severe neonatal hypoxic-ischemic encephalopathy (HIE), and the effect of SBH treatment on serum levels of neuron-specific enolase (NSE) and central nervous specific protein S100.

Methods: A prospective randomized controlled trial was conducted. From January 2015 to June 2017, 42 children with moderate to severe HIE in the neonatal intensive care unit (NICU) of the First Affiliated Hospital of Bengbu Medical College were enrolled, and they were randomly divided into SBH treatment group and routine treatment group after obtaining the consent of the guardian of the children. Read More

Med Arch 2018 Nov;72(5):316-318

Clinic for Surgery, University Clinical Center Tuzla, Tuzla, Bosnia and Herzegovina.

Introduction: Cardiovascular complications in patients with subarachnoid hemorrhage are considered to be a neurally mediated process rather than a manifestation of coronary artery disease.

Aim: The aim of study is to show the incidence and type cardiac complications after traumatic and spontaneous SAH.

Patients And Methods: The study had prospective character in which included 104 patients, with diagnosed subarachnoid hemorrhage (SAH), in the period from 2014 to 2017. Read More

Am J Case Rep 2018 Dec 7;19:1449-1452. Epub 2018 Dec 7.

Department of Internal Medicine B, Charles Nicolle Hospital, Tunis, Tunisia.

BACKGROUND Anorexia nervosa is a relatively frequently encountered eating disorder. Beyond its psychiatric significance, it is associated with multiple hematological features such as cytopenia. It can be related to gelatinous transformation of the bone marrow. Read More