4,642 results match your criteria Sinus Bradycardia


A Review of Temporary Permanent Pacemakers and a Comparison with Conventional Temporary Pacemakers.

J Innov Card Rhythm Manag 2019 May 15;10(5):3652-3661. Epub 2019 May 15.

Section of Electrophysiology & Pacing, Division of Cardiology, Department of Medicine, Baylor Scott & White Temple Memorial Hospital, Baylor Scott & White Health, Dallas, TX, USA.

Temporary cardiac pacing is commonly used in patients with life-threatening bradycardia and serves as a bridge to implantation of a permanent pacemaker (PPM). For years, passive fixation leads have been used for this purpose, offering the advantage of that they can be placed at bedside. The downside, however, is that patients must remain on telemetry and bed rest until lead removal due to the risk of displacement and failure to capture. Read More

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http://dx.doi.org/10.19102/icrm.2019.100506DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7252718PMC

Irinotecan inducing sinus pause bradycardia in a patient with small round cell cancer.

BMJ Case Rep 2020 May 31;13(5). Epub 2020 May 31.

Internal Medicine, Detroit Medical Center, Wayne State University, Detroit, Michigan, USA.

Irinotecan is a novel anticancer drug that has worked wonders in combination with other anticancer drugs. It can be used as a single chemotherapy agent in colonic cancer treatment or in combination with 5-fluorouracil. Irinotecan has been found a better salvage therapy in patients who are resistant to 5-fluorouracil. Read More

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http://dx.doi.org/10.1136/bcr-2019-232053DOI Listing

KRD-PACE Mobilization for Multiple Myeloma Patients With Significant Residual Disease Before Autologous Stem-Cell Transplantation.

Clin Lymphoma Myeloma Leuk 2020 Apr 14. Epub 2020 Apr 14.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA; Division of Medical Oncology, Department of Medicine, University of Washington, Seattle, WA; Seattle Cancer Care Alliance, Seattle, WA. Electronic address:

Background: Bortezomib has been incorporated into thalidomide and dexamethasone provided with cisplatin, doxorubicin, cyclophosphamide, and etoposide (PACE) as an intensive regimen before autologous stem-cell transplantation for multiple myeloma (MM). We examined MM patients at our center who received chemomobilization with a regimen that substituted carfilzomib and lenalidomide for bortezomib and thalidomide (KRD-PACE).

Patients And Methods: This was a retrospective study of 27 MM patients who received KRD-PACE for chemomobilization. Read More

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http://dx.doi.org/10.1016/j.clml.2020.04.002DOI Listing

Clinical analysis of sinus bradycardia in patients with severe COVID-19 pneumonia.

Crit Care 2020 May 26;24(1):257. Epub 2020 May 26.

Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, 180 Feng Lin Rd., Shanghai, 200032, China.

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http://dx.doi.org/10.1186/s13054-020-02933-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249977PMC

Plasma adenosine and neurally mediated syncope: ready for clinical use.

Europace 2020 May 25. Epub 2020 May 25.

Laboratory of Biochemistry, Timone Hospital, Marseille, France.

Either central or peripheral baroreceptor reflex abnormalities and/or alterations in neurohumoral mechanisms play a pivotal role in the genesis of neurally mediated syncope. Thus, improving our knowledge of the biochemical mechanisms underlying specific forms of neurally mediated syncope (more properly termed 'neurohumoral syncope') might allow the development of new therapies that are effective in this specific subgroup. A low-adenosine phenotype of neurohumoral syncope has recently been identified. Read More

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http://dx.doi.org/10.1093/europace/euaa070DOI Listing

Permanent pacemaker implantation rates following cardiac surgery in the modern era.

Ir J Med Sci 2020 May 22. Epub 2020 May 22.

Royal Victoria Hospital, Belfast Health and Social Care Trust, 274 Grosvenor Road, Belfast, BT12 6BA, UK.

Aims: The aim of this study was to evaluate the incidence of permanent pacemaker (PPM) implantation after cardiac surgery in our institution and investigate risk factors for PPM dependency to provide patients with accurate incidence figures at the time of consent for surgery.

Methods: Data was collected retrospectively from a single tertiary institution from October 2018 to April 2019 inclusive of 403 patients. Incidence of PPM implantation after various cardiac operations was evaluated. Read More

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http://dx.doi.org/10.1007/s11845-020-02254-yDOI Listing

Utility of Head up Tilt Table Testing to Demonstrate Selective Denervation of the Sinus Node after Cardioneuroablation.

J Atr Fibrillation 2020 Feb-Mar;12(5):2299. Epub 2020 Feb 28.

Istanbul University-Cerrahpasa, Faculty of Medicine, Department of Cardiology, Istanbul, Turkey.

A 65-year-old female who underwent cardioneuroablation for recurrent vasovagal syncope presented for 6 month follow-up visit. She had no further syncope after the procedure. A follow up tilt table testing (TT) demonstrated sinus tachycardia and variable degrees of atrioventricular block (AVB) after sublingual glyceryl trinitrate. Read More

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http://dx.doi.org/10.4022/jafib.2299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237088PMC
February 2020

A Case of Toxicity from Cannabidiol Gummy Ingestion.

Cureus 2020 Apr 16;12(4):e7688. Epub 2020 Apr 16.

Internal Medicine, NCH Healthcare System, Naples, USA.

A 56-year-old male with no known history of substance abuse and no known prior medical conditions presented via ambulance to the emergency department after being found by coworkers with bizarre behavior, vomiting, and slurred speech. He had legally purchased cannabidiol (CBD) gummies marketed for pain and anxiety relief at a gas station several hours prior. Vitals upon arrival were temperature 36. Read More

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http://dx.doi.org/10.7759/cureus.7688DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7233499PMC

Cryoballoon pulmonary vein isolation-mediated rise of sinus rate in patients with paroxysmal atrial fibrillation.

Clin Res Cardiol 2020 May 13. Epub 2020 May 13.

Department of Cardiology, University Hospital Heidelberg, INF 410, 69120, Heidelberg, Germany.

Background: Modulation of the cardiac autonomic nervous system by pulmonary vein isolation (PVI) influences the sinoatrial nodal rate. Little is known about the causes, maintenance and prognostic value of this phenomenon. We set out to explore the effects of cryoballoon PVI (cryo-PVI) on sinus rate and its significance for clinical outcome. Read More

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http://dx.doi.org/10.1007/s00392-020-01659-0DOI Listing

[Bile acids in arrhythmia].

Zhonghua Gan Zang Bing Za Zhi 2020 Apr;28(4):361-364

Department of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, China.

With the research advances on bile acid, it has gradually been discovered and confirmed that high levels of bile acids can cause various types of arrhythmias, such as sinus bradycardia, atrial fibrillation (AF), atrioventricular block and even occurrence of cardiac arrest in severe cases. In addition, it has also been found that fetuses are more susceptible to bile acid-induced arrhythmias than adults. It has been recognized that bile acids can cause arrhythmias through a variety of mechanisms, such as the effect of bile acids on ions and ion channels, receptor-mediated, vagal-mediated, and other pathways. Read More

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http://dx.doi.org/10.3760/cma.j.cn501113-20190308-00074DOI Listing

Aging-associated sinus arrest and sick sinus syndrome in adult zebrafish.

PLoS One 2020 13;15(5):e0232457. Epub 2020 May 13.

Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, United States of America.

Because of its powerful genetics, the adult zebrafish has been increasingly used for studying cardiovascular diseases. Considering its heart rate of ~100 beats per minute at ambient temperature, which is very close to human, we assessed the use of this vertebrate animal for modeling heart rhythm disorders such as sinus arrest (SA) and sick sinus syndrome (SSS). We firstly optimized a protocol to measure electrocardiogram in adult zebrafish. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0232457PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7219707PMC

[Combined Approach for Management of the Chronic Heart Failure with Preserved Left Ventricular Ejection Fraction and Permanent Atrial Fibrillation: a Case Report].

Kardiologiia 2020 Mar 30;60(4):157-160. Epub 2020 Mar 30.

M.V. Lomonosov Moscow State University.

The article described a clinical case of a patient with chronic heart failure (CHF) with preserved ejection fraction (CHF-PEF) and permanent normosystolic atrial fibrillation (AF). A 73 year-old man (body mass index, 26.4 kg /m2) with permanent normosystolic AF (duration, 10 years) was hospitalized for augmenting of CHF symptoms. Read More

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http://dx.doi.org/10.18087/cardio.2020.4.n1096DOI Listing

Selective vagal innervation principles of ganglionated plexi: step-by-step cardioneuroablation in a patient with vasovagal syncope.

J Interv Card Electrophysiol 2020 May 11. Epub 2020 May 11.

Cerrahpaşa Faculty of Medicine, Department of Cardiology, Istanbul University-Cerrahpaşa, Istanbul, Turkey.

Cardioneuroablation (CNA) is an endocardial ablation technique aiming to prevent the autonomic imbalance occurring in vasovagal syncope (VVS). A 46-year-old female was referred to our center for pacemaker implantation due to recurrent syncopal episodes despite conventional treatments. A 22-s asystole was detected on head-up tilt testing. Read More

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http://dx.doi.org/10.1007/s10840-020-00757-3DOI Listing

Possible Lyme Carditis with Sick Sinus Syndrome.

IDCases 2020 8;20:e00761. Epub 2020 Apr 8.

California State University, Los Angeles, United States.

() is a spirochete bacterium that is transmitted via the tick. Infection results in Lyme disease with possible cardiac manifestations, which is also known as Lyme carditis. Patients can present with bradycardia due to rapidly fluctuating atrioventricular block (AVB), which is the hallmark of Lyme carditis. Read More

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http://dx.doi.org/10.1016/j.idcr.2020.e00761DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7190756PMC

Reproducibility of carotid sinus massage.

Pacing Clin Electrophysiol 2020 May 4. Epub 2020 May 4.

Dept of Cardiology, , Arrhythmology Centre and Syncope Unit, Ospedali del Tigullio, Lavagna, Italy.

Aims: The reproducibility of carotid sinus massage (CSM) is debated. Aim of this study was to assess the reproducibility according to the methodology and diagnostic criteria defined by the guidelines on syncope of the European Society of Cardiology.

Method: Among 2800 patients with syncope who underwent CSM in the years 2005-2019, 109 patients (62 males; mean age 76±10 years), had performed a second CSM after a median of 28 months. Read More

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http://dx.doi.org/10.1111/pace.13934DOI Listing

Cardiac complications in patients who underwent to hematopoietic stem cell transplantation.

J Cancer Res Ther 2020 Jan-Mar;16(1):53-59

Department of Pediatrics, Division of Pediatric Oncology, Hacettepe University Faculty of Medicine and Cancer Institute, Ankara, Turkey.

Aim Of Study: Cardiac complications may be observed after hematopoietic stem cell transplantation (HSCT). Despite significant improvement in supportive care, HSCT may be associated with significant morbidity and mortality. In this study, the aim was to evaluate the frequency of clinically serious cardiac complications after HSCT in our patients. Read More

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http://dx.doi.org/10.4103/jcrt.JCRT_314_17DOI Listing

Cardiovascular disorders in hospitalized patients with dengue infection.

Enferm Infecc Microbiol Clin 2020 Apr 25. Epub 2020 Apr 25.

Unidad de Cuidados Coronarios Intensivos, Hospital Manuel Fajardo, La Habana, Cuba.

Introduction: Cardiac complications in dengue patients are not uncommon and are not diagnosed, since they are usually mild and self-limiting.

Objectives: To characterize the cardiovascular manifestations in hospitalized patients with dengue infection.

Methods: We conducted an observational, analytical, longitudinal, prospective epidemiological study, which included 427 patients treated at Manuel Fajardo Clinical-Surgical Teaching Hospital with diagnosis of dengue infection since April 2017 to April 2018. Read More

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http://dx.doi.org/10.1016/j.eimc.2020.02.032DOI Listing

Glossopharyngeal Neuralgia/Neuropathy with Hemodynamic Instability and Associated Syncope Treated with Stereotactic Radiosurgery.

World Neurosurg 2020 Apr 25;139:314-317. Epub 2020 Apr 25.

Department of Neurosurgery, Medical College of Georgia, Augusta University, Augusta, Georgia, USA.

Background: Glossopharyngeal neuralgia/neuropathy is rare, and less than 3% of cases involve cardiac arrhythmias of syncope due to activated vagal reflex pathways. Most of these cases are successfully treated with medical management with or without pacemaker placement. We present the first reported case of glossopharyngeal neuralgia/neuropathy with cardiac symptoms refractory to medical management including pacemaker placement but successfully treated with Gamma Knife Radiosurgery. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.04.130DOI Listing

The Bezold-Jarisch reflex in a patient with coronary spastic angina.

Ann Noninvasive Electrocardiol 2020 Apr 26:e12759. Epub 2020 Apr 26.

Department of Cardiovascular Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.

Acute inferior myocardial damage can induce transient bradycardia and hypotension-the Bezold-Jarisch reflex, which is explained by the preferential distribution of vagal nerves in the inferior wall of the left ventricle. We report a 76-year-old man who showed a perfusion defect in the inferior wall with redistribution on exercise scintigraphy with thallium-201. Of note, during exercise at an intensity of 100 watts, the patient's heart rate transiently decreased from 122 to 95 bpm in sinus rhythm, accompanied by ST-segment depression. Read More

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http://dx.doi.org/10.1111/anec.12759DOI Listing

Delayed-onset sinus node dysfunction in a child victim of Russell's viper bite.

Asian Cardiovasc Thorac Ann 2020 May 10;28(4):213-215. Epub 2020 Apr 10.

University Paediatrics Unit, Colombo North Teaching Hospital, Ragama, Sri Lanka.

Cardiac complications following envenomation by Russell's viper venom are uncommon. We describe a 14-year-old girl who developed delayed-onset sinus node dysfunction. She presented with mucosal bleeding, ptosis, and muscle weakness. Read More

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http://dx.doi.org/10.1177/0218492320919636DOI Listing

Validation of scoring system predicting permanent pacemaker implantation after transcatheter aortic valve replacement.

Pacing Clin Electrophysiol 2020 May 2;43(5):479-485. Epub 2020 May 2.

University of Texas McGovern Medical School, Houston, Texas.

Background: Transcatheter aortic valve replacement (TAVR) is being increasingly performed in patients with severe aortic stenosis. Despite newer generation valves, atrioventricular (AV) conduction disturbance is a common complication, necessitating permanent pacemaker (PPM) implantation in about 10% of patients. Hence, it is imperative to improve periprocedural risk stratification to predict PPM implantation after TAVR. Read More

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http://dx.doi.org/10.1111/pace.13910DOI Listing

Implantable cardiac electronic device therapy for patients with a systemic right ventricle.

Heart 2020 Apr 8. Epub 2020 Apr 8.

Adult Congenital Heart Centre and National Centre for Pulmonary Hypertension, Royal Brompton Hospital, London, United Kingdom

The systemic right ventricle (SRV), defined as the morphological right ventricle supporting the systemic circulation, is relatively common in congenital heart disease (CHD). Our review aimed at examining the current evidence, knowledge gaps and technical considerations regarding implantable cardiac electronic device therapy in patients with SRV. The risk of sinus node dysfunction (SND) after atrial switch repair and/or complete heart block in congenitally corrected transposition of great arteries requiring permanent pacing increases with age. Read More

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http://dx.doi.org/10.1136/heartjnl-2019-316202DOI Listing

Intense exercise may not be so benign: chest pain in a young athletic woman may be spontaneous coronary artery dissection (SCAD).

BMJ Case Rep 2020 Apr 6;13(4). Epub 2020 Apr 6.

Department of Cardiology, Albert Einstein Medical Center, Philadelphia, Pennsylvania, USA.

We present a 26-year-old woman who came to the emergency department with chest pain of 1 hour duration that started while she was exercising on the treadmill. At presentation, ECG showed sinus bradycardia. Initial troponin level was 0. Read More

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http://dx.doi.org/10.1136/bcr-2020-234560DOI Listing

Strategy for estimating optimal heart rate in refractory heart failure with relative sinus bradycardia: A case report.

J Cardiol Cases 2020 Apr 28;21(4):153-156. Epub 2019 Dec 28.

Department of Cardiovascular Medicine, Saga University Hospital, Saga, Japan.

Relative bradycardia (mild sinus bradycardia) is one of the major barriers for the effective treatment of hemodynamically unstable patients with heart failure and reduced cardiac output. We report a case of a man aged 58 years with an old broad anterior myocardial infarction and relative bradycardia (about 60 bpm) suffering from symptoms of congestive heart failure at rest in spite of optimal medical therapy, including the use of the inotropes. Transvenous atrial pacing during right heart catheterization indicated that an increase in heart rate (up to 80 bpm) improved hemodynamics immediately. Read More

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http://dx.doi.org/10.1016/j.jccase.2019.12.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125380PMC

Systematic Review and Meta-analysis Appraising Efficacy and Safety of Vernakalant for Cardioversion of Recent-onset Atrial Fibrillation.

J Cardiovasc Pharmacol 2020 Mar 26. Epub 2020 Mar 26.

Department of Cardiology, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan Province, People's Republic of China.

Vernakalant is a novel, relatively atrial-selective antiarrhythmic agent. In spite of its good efficacy profile and rapid onset of action, there was still controversial evidence regarding vernakalant-related adverse events. We searched Pubmed and Embase for studies that compared intravenous vernakalant with placebo or antiarrhythmic agents in patients with recent-onset atrial fibrillation (AF) lasting no more than 7 days. Read More

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http://dx.doi.org/10.1097/FJC.0000000000000832DOI Listing

Identification of Functional Variant Enhancers Associated with Atrial Fibrillation.

Circ Res 2020 Apr 6. Epub 2020 Apr 6.

Medical Biology, Amsterdam University Medical Centers.

Genome-wide association studies (GWAS) have identified a large number of common variants (single nucleotide polymorphisms) associated with atrial fibrillation (AF). These variants are located mainly in non-coding regions of the genome and likely include variants that modulate the function of transcriptional regulatory elements (REs) such as enhancers. However, the actual REs modulated by variants as well as the target genes of such REs remain to be identified. Read More

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http://dx.doi.org/10.1161/CIRCRESAHA.119.316006DOI Listing

Heart reaction of male and female with streptozotocin induced diabetes on cholinergic impacts.

Wiad Lek 2020 ;73(2):224-228

Danylo Halytsky Lviv National Medical University, Lviv, Ukraine.

Objective: The aim: Find out the nature of the changes sensitivity of the heart to the cholinergic influences the development of diabetes depending on gender.

Patients And Methods: Materials and methods: In experiments on adult male and female rats, type 1 diabetes by momentary introduction of streptozotocin at a dose of 60 mg/ kg into the peritoneal cavity was modeled. Animals were examined after 15, 30, 60 and 90 days after introduction of streptozotocin. Read More

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[INDICATORS OF CARDIOHEMODYNAMICS OF RHYTHM DISTURBANCES IN ELDERLY PEOPLE WITH CHRONIC HEART FAILURE].

Georgian Med News 2020 Feb(299):61-65

Medical University Astana, Kazakhstan.

The aim of our study was to study and analyze the electrophysiological indicators of rhythm disturbances in heart failure in elderly people who participated in the elimination of the consequences of the Chernobyl accident in the distant period. In order to assess the functional features, 50 elderly patients (65-74 years old) who participated in the liquidation of the consequences of the Chernobyl accident were examined. Patients were divided into 4 groups depending on the length of stay in an environmentally disadvantaged zone: group 1 (April-June 1986) - 8 (16%) people; 2 (June-December 1986) -14 (28%); 3 (1987-1989) -17 (34%) and group 4 (1990-91gg) -11 (22%) people. Read More

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February 2020

Cardiac rhythm abnormalities - An underestimated cardiovascular risk in adult patients with Mucopolysaccharidoses.

Mol Genet Metab 2020 Jun 27;130(2):133-139. Epub 2020 Mar 27.

Cardiology Department, Salford Royal NHS Foundation Trust, Salford, United Kingdom.

Patients with Mucopolysaccharidosis (MPS) have an increased risk of cardiovascular complications, conduction tissue abnormalities and arrhythmia; all rare but underestimated. It has been reported that conduction system defects are progressive in this group of patients and may result in sudden cardiac death. The aim of this study is to review our current practice and suggest best practice guidelines regarding the frequency of cardiac rhythm monitoring in this patient group. Read More

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http://dx.doi.org/10.1016/j.ymgme.2020.03.005DOI Listing

Short-term and intermediate-term performance and safety of left bundle branch pacing.

J Cardiovasc Electrophysiol 2020 Jun 8;31(6):1472-1481. Epub 2020 Apr 8.

Division of Cardiology, Xiamen Cardiovascular Hospital, Xiamen University, Xiamen, Fujian, China.

Introduction: Left bundle branch pacing (LBBP) is a promising new method for patients with pacing indications. This study aims to evaluate the safety and feasibility of LBBP in a relatively longer time span.

Methods And Results: A total of 164 patients were recruited for LBBP in this study. Read More

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http://dx.doi.org/10.1111/jce.14463DOI Listing

PredischaRge initiation of Ivabradine in the ManagEment of Heart Failure: Results of the PRIME-HF Trial.

Am Heart J 2020 May 28;223:98-105. Epub 2020 Feb 28.

Duke Clinical Research Institute, Division of Cardiology, Duke University School of Medicine, Durham, NC; Department of Medicine, Division of Cardiology, Duke University School of Medicine, Durham, NC.

Background: Ivabradine is guideline-recommended to reduce heart failure (HF) hospitalization in patients with stable chronic HF with reduced ejection fraction (EF). Ivabradine initiation following acute HF has had limited evaluation, and there are few randomized data in US patients. The PredischaRge initiation of Ivabradine in the ManagEment of Heart Failure (PRIME-HF) study was conducted to address predischarge ivabradine initiation in stabilized acute HF patients. Read More

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http://dx.doi.org/10.1016/j.ahj.2019.12.024DOI Listing
May 2020
4.463 Impact Factor

Long-Term Mortality in Cardioinhibitory Carotid Sinus Hypersensitivity Patient Cohort.

Arq Bras Cardiol 2020 02;114(2):245-253

Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ - Brazil2.

Background: Cardioinhibitory carotid sinus hypersensitivity (CICSH) is defined as ventricular asystole ≥ 3 seconds in response to 5-10 seconds of carotid sinus massage (CSM). There is a common concern that a prolonged asystole episode could lead to death directly from bradycardia or as a consequence of serious trauma, brain injury or pause-dependent ventricular arrhythmias.

Objective: To describe total mortality, cardiovascular mortality and trauma-related mortality of a cohort of CICSH patients, and to compare those mortalities with those found in a non-CICSH patient cohort. Read More

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http://dx.doi.org/10.36660/abc.20190008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077571PMC
February 2020

Carotid Sinus Syndrome in a Patient with Head and Neck Cancer: A Case Report.

Cureus 2020 Feb 19;12(2):e7042. Epub 2020 Feb 19.

Internal Medicine, Hospital de Cascais, Cascais, PRT.

Syncope is a common complaint among patients presenting to the emergency department. Its differential diagnosis is broad and its management varies significantly depending on the underlying etiology. This is especially complex in patients with head and neck cancer since it may appear as an initial manifestation of the disease, as a side effect of surgery or radiotherapy, or as an indicator of local recurrence. Read More

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http://dx.doi.org/10.7759/cureus.7042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7083254PMC
February 2020

HIV infection and electrocardiogram abnormalities: baseline assessment from the CHART cohort.

Clin Microbiol Infect 2020 Mar 17. Epub 2020 Mar 17.

Department of Epidemiology, School of Public Health, Fudan University, the Key Laboratory of Public Health Safety of Ministry of Education, Shanghai, China; Key Laboratory of Health Technology Assessment of Ministry of Health, Fudan University, Shanghai, China. Electronic address:

Objectives: To investigate the prevalence of various electrocardiogram (ECG) abnormalities among HIV-positive and HIV-negative individuals.

Methods: This cross-sectional evaluation included 1412 HIV-positive and 2824 HIV-negative participants aged 18 to 75 years and frequency matched by age and sex, derived from the baseline survey of Comparative HIV and Aging Research in Taizhou (CHART), China, between February and December 2017.

Results: HIV-positive individuals had higher prevalence of sinus tachycardia (5. Read More

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http://dx.doi.org/10.1016/j.cmi.2020.03.005DOI Listing

[CME ECC 65: The Athlete's ECG].

Praxis (Bern 1994) 2020 ;109(4):253-258

Universitätsspital Zürich, Klinik für Kardiologie.

CME ECC 65: The Athlete's ECG Regular, intensive training in athletes causes a modulation of the heart due to higher vagal tone and emerging hypertrophy. To assess these changes, which can be seen in an athlete's ECG as well, an international group of experts constituted contemporary standards for ECG interpretation in athletes, the "Seattle Criteria" which are discussed in this article: Athletes often have a physiologic sinus bradycardia with a heart rate between 30 and 60 bpm and a pronounced respiratory arrhythmia. A junctional rhythm with retrograde depolarisation of the atria frequently occurs as well, especially at rest. Read More

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http://dx.doi.org/10.1024/1661-8157/a003453DOI Listing
January 2020

Electrical Stimulation-Guided Approach to Pulmonary Artery Catheter Ablation in Patients with Idiopathic Pulmonary Arterial Hypertension: A Pilot Feasibility Study with a 12-Month Follow-Up.

Biomed Res Int 2020 17;2020:8919515. Epub 2020 Feb 17.

Neuromodulation Laboratory, Almazov National Medical Research Centre, Saint Petersburg, Russia.

Background: Recently, transcatheter pulmonary artery (PA) ablation aiming at sympathetic denervation has been proposed in pulmonary arterial hypertension (PAH). This pilot feasibility study aimed to assess the feasibility of selective radiofrequency PA ablation based on response to high-frequency stimulation mapping.

Methods: The study comprised 3 female patients with idiopathic PAH (IPAH). Read More

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http://dx.doi.org/10.1155/2020/8919515DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7048906PMC
February 2020

Screening for arrhythmia with the new portable single-lead electrocardiographic device (SnapECG): an application study in community-based elderly population in Nanjing, China.

Aging Clin Exp Res 2020 Mar 6. Epub 2020 Mar 6.

Key Laboratory of Environmental Medicine Engineering, Ministry of Education, Department of Epidemiology and Biostatistics, School of Public Health, Southeast University, 87 Ding Jiaqiao Rd., Nanjing, 210009, China.

Background: SnapECG is a new handheld single-lead electrocardiograph (ECG) device used for arrhythmia screening, it is widely used in clinical practice but not in primary care.

Aims: To evaluate the arrhythmia screening value of SnapECG among a community-based population.

Methods: A cross-sectional community-based study of multistage stratified cluster sampling was conducted from March 1st to April 30th 2019. Read More

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http://dx.doi.org/10.1007/s40520-020-01512-4DOI Listing

Cardiac dysregulation following intrahippocampal kainate-induced status epilepticus.

Sci Rep 2020 Mar 4;10(1):4043. Epub 2020 Mar 4.

Department of Neuroscience, Baylor College of Medicine, Houston, TX, USA.

Status epilepticus (SE) is a prevalent disorder associated with significant morbidity, including the development of epilepsy and mortality. Cardiac arrhythmias (i.e. Read More

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http://dx.doi.org/10.1038/s41598-020-60324-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7055295PMC

Bisoprolol transdermal patch treatment for patients with atrial fibrillation after noncardiac surgery: A single-center retrospective study of 61 patients.

SAGE Open Med 2020 20;8:2050312120907817. Epub 2020 Feb 20.

Department of Onco-Cardiology, Osaka International Cancer Institute, Osaka, Japan.

Objectives: Atrial fibrillation after surgery is associated with increased rates of heart failure and ischemic stroke, and extension of hospitalization. Bisoprolol is a β-blocker used to reduce heart rate and manage arrhythmias during atrial fibrillation. However, the safety and efficacy of bisoprolol transdermal patch treatment in patients with postoperative atrial fibrillation remain unclear. Read More

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http://dx.doi.org/10.1177/2050312120907817DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036496PMC
February 2020

Ventricular fibrillation associated with vasospastic angina pectoris in Fabry disease: a case report.

Eur Heart J Case Rep 2019 Dec 21;3(4):1-5. Epub 2019 Oct 21.

Department of Cardiology, Nagahama Red Cross Hospital, 14-7, Miyamae-cho, Nagahama-shi, Shiga 526-0053, Japan.

Background: Fabry disease (FD) is an X-linked lysosomal storage disorder resulting from a deficiency in alpha-galactosidase A. The major causes of death due to cardiac complications include life-threatening arrhythmias. In addition, life-threatening arrhythmias may be related to myocardial fibrosis assessed by late gadolinium enhancement (LGE). Read More

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http://dx.doi.org/10.1093/ehjcr/ytz192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7042139PMC
December 2019

Atropine-induced sinus tachycardia protects against exercise-induced ventricular arrhythmias in patients with catecholaminergic polymorphic ventricular tachycardia.

Europace 2020 Apr;22(4):643-648

Vanderbilt Center for Arrhythmia Research and Therapeutics, Vanderbilt University Medical Center, Nashville, TN, USA.

Aims: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited arrhythmia syndrome characterized by exercise-induced ventricular arrhythmias, sudden death, and sinus bradycardia. Elevating supraventricular rates with pacing or atropine protects against catecholaminergic ventricular arrhythmias in a CPVT mouse model. We tested the hypothesis that increasing sinus heart rate (HR) with atropine prevents exercise-induced ventricular arrhythmias in CPVT patients. Read More

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http://dx.doi.org/10.1093/europace/euaa029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7132542PMC

Optimal Multi-Stage Arrhythmia Classification Approach.

Sci Rep 2020 Feb 19;10(1):2898. Epub 2020 Feb 19.

Chapman University, Orange, USA.

Arrhythmia constitutes a problem with the rate or rhythm of the heartbeat, and an early diagnosis is essential for the timely inception of successful treatment. We have jointly optimized the entire multi-stage arrhythmia classification scheme based on 12-lead surface ECGs that attains the accuracy performance level of professional cardiologists. The new approach is comprised of a three-step noise reduction stage, a novel feature extraction method and an optimal classification model with finely tuned hyperparameters. Read More

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http://dx.doi.org/10.1038/s41598-020-59821-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7031229PMC
February 2020

Novel Na/Ca Exchanger Inhibitor ORM-10962 Supports Coupled Function of Funny-Current and Na/Ca Exchanger in Pacemaking of Rabbit Sinus Node Tissue.

Front Pharmacol 2019 29;10:1632. Epub 2020 Jan 29.

MTA-SZTE Research Group of Cardiovascular Pharmacology, Hungarian Academy of Sciences, Szeged, Hungary.

Background And Purpose: The exact mechanism of spontaneous pacemaking is not fully understood. Recent results suggest tight cooperation between intracellular Ca handling and sarcolemmal ion channels. An important player of this crosstalk is the Na/Ca exchanger (NCX), however, direct pharmacological evidence was unavailable so far because of the lack of a selective inhibitor. Read More

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http://dx.doi.org/10.3389/fphar.2019.01632DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7000430PMC
January 2020

Clinical Outcomes of Various Management Strategies for Symptomatic Bradycardia.

Clin Med Res 2020 Feb 14. Epub 2020 Feb 14.

Division of Cardiovascular Diseases, Mayo Clinic Hospital, Phoenix, Arizona, USA.

Objective: To determine clinical outcomes of various management strategies for reversible and irreversible causes of symptomatic bradycardia in the inpatient setting.

Design: Retrospective observational study.

Setting: Emergency Room and Inpatient. Read More

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http://dx.doi.org/10.3121/cmr.2019.1507DOI Listing
February 2020

[The Pacemaker and Implantable Cardioverter-Defibrillator Registry of the Italian Association of Arrhythmology and Cardiac Pacing - Annual report 2018].

G Ital Cardiol (Rome) 2020 Feb;21(2):157-169

Dipartimento di Medicina Ambientale e Salute Pubblica, Università degli Studi, Padova.

Background: The pacemaker (PM) and implantable cardioverter-defibrillator (ICD) Registry of the Italian Association of Arrhythmology and Cardiac Pacing (AIAC) monitors the main epidemiological data in real-world practice. The survey for the 2018 activity collects information about demographics, clinical characteristics, main indications for PM/ICD therapy and device types from the Italian collaborating centers.

Methods: The Registry collects prospectively national PM and ICD implantation activity on the basis of European cards. Read More

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http://dx.doi.org/10.1714/3300.32710DOI Listing
February 2020

Global REACH: Assessment of Brady-Arrhythmias in Andeans and Lowlanders During Apnea at 4330 m.

Front Physiol 2019 22;10:1603. Epub 2020 Jan 22.

Neurovascular Health Lab, Faculty of Kinesiology, Sport, and Recreation, University of Alberta, Edmonton, AB, Canada.

Ascent to altitude increases the prevalence of arrhythmogenesis in low-altitude dwelling populations (Lowlanders). High altitude populations (i.e. Read More

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http://dx.doi.org/10.3389/fphys.2019.01603DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6987448PMC
January 2020

Risk factors and survival of patients with permanent pacemaker implantation after heart transplantation.

J Thorac Dis 2019 Dec;11(12):5440-5452

Department of Cardiology, Angiology and Pneumology, Heidelberg University Hospital, Heidelberg, Germany.

Background: Permanent pacemaker (PPM) implantation after heart transplantation (HTX) may be required due to severe bradycardia. The aim of this study was to investigate the risk factors, indications, perioperative outcomes and complications of PPM implantation after HTX as well as the underlying effect on post-transplant mortality including causes of death.

Methods: This registry study included 621 patients receiving HTX at Heidelberg Heart Center between 1989 and 2018. Read More

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http://dx.doi.org/10.21037/jtd.2019.11.45DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6988084PMC
December 2019

Outcomes following cardioversion for patients with cardiac amyloidosis and atrial fibrillation or atrial flutter.

Am Heart J 2020 04 8;222:26-29. Epub 2020 Jan 8.

Division of Cardiovascular Disease, Duke University Medical Center, Durham, NC. Electronic address:

Atrial arrhythmias commonly occur in patients with cardiac amyloidosis (CA), but there is limited data on safety or efficacy of cardioversion (DCCV) for management of these rhythms in CA. We identified 25 patients with CA (20 with transthyretin (TTR) and 5 with light-chain (AL) amyloidosis) at Duke University who underwent DCCV for atrial arrhythmias and documented procedural success, complications, and long-term morbidity and mortality. While DCCV successfully restored sinus rhythm in 96% of patients, 36% of patients experienced immediate procedural complications (primarily bradycardia and hypotension), 80% had recurrence of atrial arrhythmias at 1 year, and 52% died at 3 years, highlighting short-term safety concerns, long-term inefficacy, and poor prognosis associated with symptomatic atrial arrhythmias requiring DCCV in CA. Read More

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http://dx.doi.org/10.1016/j.ahj.2020.01.002DOI Listing

endocarditis of the tricuspid valve.

J Community Hosp Intern Med Perspect 2019 14;9(6):495-498. Epub 2019 Dec 14.

Department of Internal Medicine, MedStar Health Internal Medicine Residency Program, Baltimore, MD, USA.

Infective endocarditis (IE) is a focus of infection which effects the endocardium, specifically the heart valves or intra-cardiac devices. A 64-year-old male with gastric carcinoma and no prior cardiac history presented to the emergency room with altered mental status. Initial investigations showed the patient had a leukocytosis with a left shift. Read More

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http://dx.doi.org/10.1080/20009666.2019.1684424DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6968256PMC
December 2019