4,462 results match your criteria Sinus Bradycardia


Hemodialysis-induced bradycardia, "a plumbing issue": Resolved with catheter repositioning.

Hemodial Int 2019 Feb 18. Epub 2019 Feb 18.

Department of Medicine, Division of Nephrology, State University of New York (SUNY) Upstate Medical University, Syracuse, New York.

Sudden cardiac death (SCD) is reported as leading cause of death in patients on chronic hemodialysis. Arrhythmias are proposed to be a major predisposing factor for SCD. However, triggers for potentially lethal arrhythmias are not well understood. Read More

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http://dx.doi.org/10.1111/hdi.12714DOI Listing
February 2019

Risk of cardiac arrhythmias after electrical accident: a single-center study of 480 patients.

Clin Res Cardiol 2019 Feb 15. Epub 2019 Feb 15.

Semmelweis University Heart and Vascular Centre, Városmajor u. 68, Budapest, 1122, Hungary.

Objective: Patients with electrical injury are considered to be at high risk of cardiac arrhythmias. Due to the small number of studies, there is no widely accepted guideline regarding the risk assessment and management of arrhythmic complications after electrical accident (EA). Our retrospective observational study was designed to determine the prevalence of ECG abnormalities and cardiac arrhythmias after EA, to evaluate the predictive value of cardiac biomarkers for this condition and to assess in-hospital and 30-day mortality. Read More

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http://dx.doi.org/10.1007/s00392-019-01420-2DOI Listing
February 2019
1 Read

Vomiting and Dehydration in a 2-Year-Old.

Pediatrics 2019 Feb 12. Epub 2019 Feb 12.

Divisions of Emergency Medicine and.

A 2-year-old girl with a past medical history of cutaneous mastocytosis and eczema presented with 1 day of yellow-green, nonbloody vomiting, bradycardia, and listlessness. She was evaluated by her pediatrician and sent to the emergency department because of concern for dehydration. In the emergency department, she improved with fluid rehydration but still had decreased energy and bradycardia. Read More

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http://dx.doi.org/10.1542/peds.2018-0504DOI Listing
February 2019
1 Read

Severe Bradycardia Prior to Coronary Artery Bypass Graft Surgery: A Case Report.

J Tehran Heart Cent 2018 Jul;13(3):136-139

Department of Cardiothoracic Surgery, Barts Heart Centre, St Bartholomew's Hospital, London, UK.

Intraventricular conduction abnormalities following cardiac surgery have been thoroughly described, especially after valvular surgery. It is also widely known that several anesthetic factors can cause autonomic disturbances resulting in the unmasking of sinus node dysfunction, significant bradycardia, and cardiovascular collapse during the intraoperative period. However, little is known about asymptomatic episodes, especially those occurring prior to coronary artery bypass grafting (CABG). Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368915PMC
July 2018
3 Reads

Fetal dysrhythmias.

Best Pract Res Clin Obstet Gynaecol 2019 Jan 9. Epub 2019 Jan 9.

Royal Brompton and Harefield NHS Foundation Trust, Sydney Street, London, SW3 6NP, UK; Fetal Medicine Unit, St George's University Hospital, Blackshaw Road, London, SW17 0QT, UK; Molecular and Clinical Sciences Research Institute, St George's, University of London, Cranmer Terrace, London, SW17 0RE, UK. Electronic address:

Fetal dysrhythmias are common abnormalities, usually manifesting as irregular rhythms. Although most irregularities are benign and caused by isolated atrial ectopics, in a few cases, rhythm irregularity may indicate partial atrioventricular block, which has different etiological and prognostic implications. We provide a flowchart for the initial management of irregular rhythm to help select cases requiring urgent specialist referral. Read More

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http://dx.doi.org/10.1016/j.bpobgyn.2019.01.002DOI Listing
January 2019
1 Read

Indications for permanent pacing in dogs and cats.

J Vet Cardiol 2019 Jan 29. Epub 2019 Jan 29.

Clinica Veterinaria Malpensa, Viale Marconi 27, 21017 Samarate, Varese, Italy.

Pacemaker implantation is considered as a standard procedure for treatment of symptomatic bradycardia in both dogs and cats. Advanced second-degree and third-degree atrioventricular blocks, sick sinus syndrome, persistent atrial standstill, and vasovagal syncope are the most common rhythm disturbances that require pacing to either alleviate clinical signs or prolong survival. Most pacemakers are implanted transvenously, using endocardial leads, but rarely epicardial leads may be necessary. Read More

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http://dx.doi.org/10.1016/j.jvc.2018.12.003DOI Listing
January 2019
2 Reads

Congenital adrenal hyperplasia with salt-wasting crisis and arrhythmia: a case study.

BMJ Case Rep 2019 Jan 29;12(1). Epub 2019 Jan 29.

Department of Paediatrics, Barking Havering and Redbridge University Hospitals NHS Trust, Romford, UK.

We report a case of a 10-day-old male infant who presented to the emergency department with severe electrolyte imbalance and life-threatening arrhythmia. The parents reported a 3-day history of poor feeding and lethargy. On examination, he was bradycardic (heart rate of 65 beats/min) with signs of dehydration. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22756
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http://dx.doi.org/10.1136/bcr-2018-227565DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352754PMC
January 2019
21 Reads

Behavior of leadless AV synchronous pacing during atrial arrhythmias and stability of the atrial signals over time-Results of the MARVEL Evolve subanalysis.

Pacing Clin Electrophysiol 2019 Jan 27. Epub 2019 Jan 27.

Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium.

Introduction: The MARVEL study demonstrated at a single time point that accelerometer (ACC)-based atrial sensing improves atrioventricular (AV) synchrony (AVS) in patients with AV block and a Micra pacemaker (Medtronic, Minneapolis, MN, USA). The purpose of the MARVEL Evolve substudy was to assess the performance over time.

Methods: This prospective single-center study compared AVS and ACC signals at two visits ≥6 months apart. Read More

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http://doi.wiley.com/10.1111/pace.13615
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http://dx.doi.org/10.1111/pace.13615DOI Listing
January 2019
5 Reads

[High performance athlete's heart: Results of a cross-sectional survey conducted in Bobo-Dioulasso, Burkina Faso].

Ann Cardiol Angeiol (Paris) 2019 Feb 23;68(1):17-21. Epub 2019 Jan 23.

Unité de formation et de recherche en sciences de la santé, université de Ouagadougou, Ouagadougou, Burkina Faso.

Purpose Of The Study: To describe the clinical, electrocardiographic and echocardiographic features of the athlete's heart.

Patients And Methods: This was a cross-sectional study conducted from August 2015 to February 2016 in the city of Bobo-Dioulasso in Burkina Faso. Athletes of high level of training (at least 8hours of weekly training, for more than six months regardless of the type of sport) have benefited from: a clinical examination, an electrocardiography and a cardiac ultrasound rest to look for electrical, morphological and functional cardiac changes. Read More

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http://dx.doi.org/10.1016/j.ancard.2018.06.001DOI Listing
February 2019
2 Reads

Case 262: Isolated Left Ventricular Apical Hypoplasia.

Radiology 2019 Feb;290(2):569-573

From the Department of Radiology and Medical Imaging (A.H.S., M.S.R., J.R.D.) and Division of Cardiology (R.A.M.), Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229.

History A 17-year-old white male adolescent was re-evaluated for a withheld cardiac condition initially detected during prenatal imaging at an outside institution. He had previously experienced intermittent episodes of shortness of breath, chest pain, and palpitations with exertion, but more recently he had been asymptomatic. He had no other comorbidities and no family history of congenital heart disease, cardiomyopathy, arrhythmia, or sudden cardiac death. Read More

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http://dx.doi.org/10.1148/radiol.2019161902DOI Listing
February 2019
3 Reads

Familial Sinus Node Disease Caused by a Gain of GIRK (G-Protein Activated Inwardly Rectifying K Channel) Channel Function.

Circ Genom Precis Med 2019 Jan;12(1):e002238

Department of Cardiovascular Medicine, Institute for Genetics of Heart Diseases (IfGH), University Hospital Münster, Germany (J.K., B.S., S.Z., G.S., E.S.-B.).

Background: Inherited forms of sinus node dysfunction (SND) clinically include bradycardia, sinus arrest, and chronotropic incompetence and may serve as disease models to understand sinus node physiology and impulse generation. Recently, a gain-of-function mutation in the G-protein gene GNB2 led to enhanced activation of the GIRK (G-protein activated inwardly rectifying K channel). Thus, human cardiac GIRK channels are important for heart rate regulation and subsequently, genes encoding their subunits Kir3. Read More

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https://www.ahajournals.org/doi/10.1161/CIRCGEN.118.002238
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http://dx.doi.org/10.1161/CIRCGEN.118.002238DOI Listing
January 2019
10 Reads

Asymptomatic bradycardia amongst endurance athletes.

Phys Sportsmed 2019 Jan 14:1-4. Epub 2019 Jan 14.

c Department of Cardiology , Hopital Pontchaillou Service de medecine du sport , Rennes , France.

It is established that an intensive training results in a lower average resting heart rate. Management of bradycardia in an athlete can be difficult given the underlying mechanisms are not clearly understood. The authors reviewed the different mechanisms described in the literature, including recent advances in physiology regarding remodeling of ion channels, which may partially explain bradycardia in athletes. Read More

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http://dx.doi.org/10.1080/00913847.2019.1568769DOI Listing
January 2019
2 Reads

Gender-Related Electrocardiographic Changes in Athletes.

Curr Health Sci J 2018 Jan-Mar;44(1):29-33. Epub 2018 Mar 28.

Department of Physiology, University of Medicine and Pharmacy of Craiova, Romania.

Objectives: To assess gender differences in training-related electrocardiographic (ECG) patterns of athletes, highlighting the importance of these differences for ECG interpretation used in the cardiovascular screening of athletes.

Design: Observational cross-sectional study.

Methods: 315 athletes were enrolled in the study (150 males and 165 females, mean age 23,7±6,6 and 20,7±6,8, respectively). Read More

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http://dx.doi.org/10.12865/CHSJ.44.01.05DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295177PMC

Cellular Mechanisms of Sinus Node Dysfunction in Carriers of the -E161K Mutation and Role of the H558R Polymorphism.

Authors:
Ronald Wilders

Front Physiol 2018 18;9:1795. Epub 2018 Dec 18.

Department of Medical Biology, Amsterdam University Medical Centers, Amsterdam, Netherlands.

Carriers of the E161K mutation in the gene, encoding the Na1.5 pore-forming α-subunit of the ion channel carrying the fast sodium current (I), show sinus bradycardia and occasional exit block. Voltage clamp experiments in mammalian expression systems revealed a mutation-induced 2. Read More

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https://www.frontiersin.org/article/10.3389/fphys.2018.01795
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http://dx.doi.org/10.3389/fphys.2018.01795DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305593PMC
December 2018
5 Reads

Identification of a novel exon3 deletion of RYR2 in a family with catecholaminergic polymorphic ventricular tachycardia.

Ann Noninvasive Electrocardiol 2019 Jan 7:e12623. Epub 2019 Jan 7.

Department of Cardiovascular Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan.

Background: RYR2, encoding cardiac ryanodine receptor, is the major responsible gene for catecholaminergic polymorphic ventricular tachycardia (CPVT). Meanwhile, KCNJ2, encoding inward-rectifier potassium channel (I ), can be the responsible gene for atypical CPVT. We recently encountered a family with CPVT and sought to identify a responsible gene variant. Read More

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http://dx.doi.org/10.1111/anec.12623DOI Listing
January 2019
8 Reads

Suspected Oseltamivir-induced bradycardia in a pediatric patient: A case report from King Abdullah Specialist Children's Hospital, Riyadh, Saudi Arabia.

Clin Pract 2018 Oct 28;8(4):1094. Epub 2018 Nov 28.

College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.

In recent years, influenza infection in the pediatric population has been a widescale issue that physicians face during the winter season. Medications used to treat and prevent such infections include Oseltamivir, an anti-viral neuraminidase inhibitor developed for both influenzas A and B. The most commonly well-known and manifesting adverse effects are nausea, vomiting and gastrointestinal upset. Read More

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http://dx.doi.org/10.4081/cp.2018.1094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280064PMC
October 2018
3 Reads

Pulmonary veins isolation to retard pacemaker implantation.

Clin Case Rep 2018 Dec 30;6(12):2445-2450. Epub 2018 Oct 30.

Cardiology Centre Hospitalier Universitaire Dinant/Godinne Yvoir Belgium.

Sick sinus syndrome is uncommon in children, and syndromic forms are rare. Some forms of sick sinus syndrome like the bradycardia-tachycardia type could be managed by a radiofrequency ablation, even in young children, and could be helpful to delay the implantation of a pacemaker. Read More

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http://dx.doi.org/10.1002/ccr3.1865DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293180PMC
December 2018
2 Reads

Canine and human sinoatrial node: differences and similarities in the structure, function, molecular profiles, and arrhythmia.

J Vet Cardiol 2018 Dec 14. Epub 2018 Dec 14.

Department of Physiology and Cell Biology, Dorothy M. Davis Heart & Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH, USA. Electronic address:

The sinoatrial node (SAN) is the primary pacemaker in canine and human hearts. The SAN in both species has a unique three-dimensional heterogeneous structure characterized by small pacemaker myocytes enmeshed within fibrotic strands, which partially insulate the cells from aberrant atrial activation. The SAN pacemaker tissue expresses a unique signature of proteins and receptors that mediate SAN automaticity, ion channel currents, and cell-to-cell communication, which are predominantly similar in both species. Read More

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http://dx.doi.org/10.1016/j.jvc.2018.10.004DOI Listing
December 2018
1 Read

Pacemaker implantation for treating migraine-like headache secondary to cardiac arrhythmia: A case report.

Medicine (Baltimore) 2018 Dec;97(50):e13629

Department of Neurology, The Second Hospital of Jilin University, Changchun, China.

Rationale: Co-occurrence of headache and arrhythmia is not rare. However, their causal relationship remains unclear. Here, we described a case of migraine-like headache relieving with pacemaker implantation. Read More

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http://dx.doi.org/10.1097/MD.0000000000013629DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320178PMC
December 2018
1 Read

Hemodynamic consequences of premature ventricular contractions: Association of mechanical bradycardia and postextrasystolic potentiation with premature ventricular contraction-induced cardiomyopathy.

Heart Rhythm 2018 Dec 11. Epub 2018 Dec 11.

University Hospital Rangueil, Toulouse, France; Unité Inserm U 1048, Toulouse, France. Electronic address:

Background: The relationships between hemodynamic consequences of premature ventricular contractions (PVCs) and development of premature ventricular contraction-induced cardiomyopathy (PVC-CM) have not been investigated.

Objective: The purpose of this study was to correlate concealed mechanical bradycardia and/or postextrasystolic potentiation (PEP) to PVC-CM.

Methods: Invasive arterial pressure measurements from 17 patients with PVC-CM and 16 controls with frequent PVCs were retrospectively analyzed. Read More

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http://dx.doi.org/10.1016/j.hrthm.2018.12.008DOI Listing
December 2018
2 Reads

Cardiac Involvement by Yellow Fever(from the PROVAR+ Study).

Am J Cardiol 2019 Mar 4;123(5):833-838. Epub 2018 Dec 4.

Serviço de Cardiologia e Cirurgia Cardiovascular e Centro de Telessaúde do Hospital das Clínicas da UFMG, Belo Horizonte, Minas Gerais, Brazil; Departamento de Clínica Médica, Faculdade de Medicina da Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil. Electronic address:

Incidence of Yellow Fever (YF) has increased in Brazil, and cardiac findings such as bradyarrhythmias and conduction abnormalities have been described. We aimed to perform a comprehensive cardiac evaluation of patients with YF, and to assess the association between cardiac involvement and disease severity. Patients hospitalized with YF from February to March 2018 underwent clinical and laboratory evaluation, focused bedside echocardiography (GE Vivid IQ), electrocardiogram and, in case of alterations, 24-hours Holter. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029149183213
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http://dx.doi.org/10.1016/j.amjcard.2018.11.032DOI Listing
March 2019
14 Reads

Lambda-like ST-segment elevation in acute myocardial infarction triggered by coronary spasm may be a new risk predictor for lethal ventricular arrhythmia: A case report.

Medicine (Baltimore) 2018 Dec;97(49):e13561

Department of Cardiology.

Rationale: The lambda-like ST-elevation electrocardiography (ECG) pattern is extremely rare in patients with type 2 myocardial infarction (T2MI) triggered by coronary spasm. When this ECG pattern appears, sudden cardiac death (SCD) caused by lethal ventricular arrhythmia may occur because clinicians do not pay sufficient attention to this phenomenon.

Patient Concerns: We describe a 41-year-old man who presented with steep down-sloping ST-segment elevation, paroxysmal ventricular tachycardia, severe sinus bradycardia, and intermittent complete atrioventricular block on ECG during the sudden recurrence of clinical symptoms. Read More

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http://dx.doi.org/10.1097/MD.0000000000013561DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310568PMC
December 2018

[Efficacy and safety of selective brain hypothermia therapy on neonatal hypoxic-ischemic encephalopathy].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2018 Nov;30(11):1046-1050

Department of Pediatrics, the First Affiliated Hospital of Bengbu Medical College, Bengbu 233004, Anhui, China (Chen X, Peng WS, Zhang Z, Zhao Q, Zhou Y, Chen L); Department of Pediatric, Anhui Provincial Hospital, the First Affiliated Hospital of University of Science and Technology of China, Hefei 230001, Anhui, China (Pan JH). Corresponding author: Pan Jiahua, Email:

Objective: To evaluate the efficacy and safety of selective brain hypothermia (SBH) in the treatment of neonates with moderate or severe neonatal hypoxic-ischemic encephalopathy (HIE), and the effect of SBH treatment on serum levels of neuron-specific enolase (NSE) and central nervous specific protein S100.

Methods: A prospective randomized controlled trial was conducted. From January 2015 to June 2017, 42 children with moderate to severe HIE in the neonatal intensive care unit (NICU) of the First Affiliated Hospital of Bengbu Medical College were enrolled, and they were randomly divided into SBH treatment group and routine treatment group after obtaining the consent of the guardian of the children. Read More

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http://dx.doi.org/10.3760/cma.j.issn.2095-4352.2018.011.007DOI Listing
November 2018
1 Read

Incidence of Cardiac Dysfunction After Brain Injury.

Med Arch 2018 Nov;72(5):316-318

Clinic for Surgery, University Clinical Center Tuzla, Tuzla, Bosnia and Herzegovina.

Introduction: Cardiovascular complications in patients with subarachnoid hemorrhage are considered to be a neurally mediated process rather than a manifestation of coronary artery disease.

Aim: The aim of study is to show the incidence and type cardiac complications after traumatic and spontaneous SAH.

Patients And Methods: The study had prospective character in which included 104 patients, with diagnosed subarachnoid hemorrhage (SAH), in the period from 2014 to 2017. Read More

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http://dx.doi.org/10.5455/medarh.2018.72.316-318DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282908PMC
November 2018
1 Read

Gelatinous Transformation of Bone Marrow in a Patient with Anorexia Nervosa: An Uncommon but Reversible Etiology.

Am J Case Rep 2018 Dec 7;19:1449-1452. Epub 2018 Dec 7.

Department of Internal Medicine B, Charles Nicolle Hospital, Tunis, Tunisia.

BACKGROUND Anorexia nervosa is a relatively frequently encountered eating disorder. Beyond its psychiatric significance, it is associated with multiple hematological features such as cytopenia. It can be related to gelatinous transformation of the bone marrow. Read More

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http://dx.doi.org/10.12659/AJCR.911287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293863PMC
December 2018
1 Read

Comparison of Metoprolol and Tramadol with Remifentanil in Endoscopic Sinus Surgery: A Randomised Controlled Trial.

Turk J Anaesthesiol Reanim 2018 Dec 6;46(6):424-433. Epub 2018 Sep 6.

Department of Otorhinolaryngology, Recep Tayyip Erdoğan University School of Medicine, Rize, Turkey.

Objective: Controlled hypotension is commonly induced during functional endoscopic sinus surgery to limit mucosal bleeding. This may be detrimental to elderly patients and patients with arterial stenosis. The aim of this pilot study was to determine if a normotensive anaesthetic technique with sufficient analgesia and without profound vasodilation may reduce intraoperative bleeding and incidence of adverse haemodynamic effects associated with vasodilation and variable rate continuous infusions. Read More

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http://dx.doi.org/10.5152/TJAR.2018.28999DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223865PMC
December 2018
1 Read

Severe Sinus Bradycardia in Puumala virus infection.

Int J Infect Dis 2019 Feb 29;79:75-76. Epub 2018 Nov 29.

Service de Médecine Interne, CHRU de Besançon, Besançon, France. Electronic address:

Puumala orthohantavirus (PUUV) is the most prevalent of the four species of zoonotic hantaviruses found in Europe, causing nephropathia epidemica, a mild form of hemorrhagic fever with acute kidney injury that presents with elevated serum creatinine level, proteinuria and hematuria. The febrile phase of the infection begins with flu-like syndrome and visual disturbance. Laboratory results can show thrombocytopenia. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S12019712183459
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http://dx.doi.org/10.1016/j.ijid.2018.11.019DOI Listing
February 2019
12 Reads

Cyclical sinus bradycardia and atrioventricular block induced by ticagrelor.

HeartRhythm Case Rep 2018 Nov 8;4(11):527-529. Epub 2018 Aug 8.

Department of Cardiology, Montreal Heart Institute, Université de Montréal, Montreal, Canada.

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http://dx.doi.org/10.1016/j.hrcr.2018.07.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6241168PMC
November 2018
1 Read

Acute Pancreatitis Mimicking ST-Segment Elevation Myocardial Infarction.

Case Rep Cardiol 2018 24;2018:9382904. Epub 2018 Oct 24.

Department of Internal Medicine, Einstein Medical Center, Philadelphia, PA, USA.

Introduction: Electrocardiographic changes imitating myocardial ischemia have been occasionally reported in patients with intra-abdominal pathology including acute pancreatitis.

Case Report: A 60-year-old man with no past medical history presented to the emergency department (ED) after a syncopal episode. In ED, his vitals were stable. Read More

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https://www.hindawi.com/journals/cric/2018/9382904/
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http://dx.doi.org/10.1155/2018/9382904DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220407PMC
October 2018
10 Reads

Intraoperative Management of a Patient With Impaired Cardiac Function Undergoing Simultaneous ABO-Compatible Liver and ABO-Incompatible Kidney Transplant From 2 Living Donors: A Case Report.

Transplant Proc 2018 Dec 7;50(10):3988-3994. Epub 2018 Sep 7.

Department of Anesthesiology and Pain Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea. Electronic address:

Background: Combined liver and kidney transplant is a very complex surgery. To date, there has been no report on the intraoperative management of patients with impaired cardiac function undergoing simultaneous ABO-compatible liver and ABO-incompatible kidney transplant from 2 living donors.

Case Report: A 60-year-old man underwent simultaneous ABO-compatible liver and ABO-incompatible kidney transplant from 2 living donors because of IgA nephropathy and alcoholic liver cirrhosis. Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.08.017DOI Listing
December 2018
9 Reads

Clinical approach to cardiac pauses in congenital central hypoventilation syndrome.

Pediatr Pulmonol 2019 Feb 20;54(2):E4-E6. Epub 2018 Nov 20.

Division and Chair of Cardiology, Spedali Civili Hospital, University of Brescia, Brescia, Italy.

Congenital central hypoventilation syndrome (CCHS) patients may have heart rhythm disorders related to autonomic nervous system dysfunction such as, sinus bradycardia and transient asystole with potentially dramatic syncopal events. The diagnosis of these cardiac alterations may be challenging with conventional periodical Holter monitoring. The case shows how continuous heart rhythm monitoring provided by the implantable cardiac monitor (ICM) may play a crucial role for their early diagnosis and the choice of the appropriate therapeutic intervention. Read More

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http://dx.doi.org/10.1002/ppul.24189DOI Listing
February 2019
16 Reads

Intracranial hypertension caused by superior sagittal sinus stenosis secondary to a depressed skull fracture: Case report and review of the literature.

Neurocirugia (Astur) 2018 Nov 15. Epub 2018 Nov 15.

Department of Neurosurgery, Complejo Hospitalario de Navarra, Pamplona (Navarra), Spain.

Depressed fractures that occur on the superior sagittal sinus (SSS) cause stenosis or thrombosis of the sinus in 11.5% of cases. Despite this, the appearance of signs and symptoms derived from high intracranial pressure is an infrequent event. Read More

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http://dx.doi.org/10.1016/j.neucir.2018.10.002DOI Listing
November 2018
1 Read

Small-conductance calcium-activated potassium current modulates the ventricular escape rhythm in normal rabbit hearts.

Heart Rhythm 2018 Nov 13. Epub 2018 Nov 13.

Krannert Institute of Cardiology and Division of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana. Electronic address:

Background: The apamin-sensitive small-conductance calcium-activated K (SK) current I modulates automaticity of the sinus node. I blockade by apamin causes sinus bradycardia.

Objective: The purpose of this study was to test the hypothesis that I modulates ventricular automaticity. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15475271183111
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http://dx.doi.org/10.1016/j.hrthm.2018.10.033DOI Listing
November 2018
9 Reads

Concomitant SK current activation and sodium current inhibition cause J wave syndrome.

JCI Insight 2018 Nov 15;3(22). Epub 2018 Nov 15.

Krannert Institute of Cardiology and Division of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.

The mechanisms of J wave syndrome (JWS) are incompletely understood. Here, we showed that the concomitant activation of small-conductance calcium-activated potassium (SK) current (IKAS) and inhibition of sodium current by cyclohexyl-[2-(3,5-dimethyl-pyrazol-1-yl)-6-methyl-pyrimidin-4-yl]-amine (CyPPA) recapitulate the phenotypes of JWS in Langendorff-perfused rabbit hearts. CyPPA induced significant J wave elevation and frequent spontaneous ventricular fibrillation (SVF), as well as sinus bradycardia, atrioventricular block, and intraventricular conduction delay. Read More

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https://insight.jci.org/articles/view/122329
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http://dx.doi.org/10.1172/jci.insight.122329DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302939PMC
November 2018
13 Reads

Lithium intoxication presenting as altered consciousness and arrhythmia with cardiogenic shock: A case report.

Medicine (Baltimore) 2018 Nov;97(45):e13129

Department of Emergency Medicine, Kaohsiung Medical University Hospital.

Rationale: Lithium has been used to treat bipolar disorder. Lithium has a narrow therapeutic index, with a therapeutic level between 0.6 and 1. Read More

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http://Insights.ovid.com/crossref?an=00005792-201811090-0005
Publisher Site
http://dx.doi.org/10.1097/MD.0000000000013129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250446PMC
November 2018
14 Reads

"BROAD Effect: Bradycardia in Obstructive Airway Disease"An Unusual Phenomenon: A Case Report.

Indian J Crit Care Med 2018 Oct;22(10):757-759

Department of Cardiology, Fortis Hospital, Ludhiana, Punjab, India.

Non Invasive Ventilation (NIV) is frequently used in Obstructive Airway Disease (OAD) especially COPD (Chronic Obstructive Pulmonary Disease). Patients often get hypoxic or retain carbon dioxide during attempts to feed the patient orally or trial of intermittent support. However, patient developing sudden bradycardia by mere taking off the mask and reverting to sinus rhythm as soon as mask is put back is extremely rare. Read More

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http://www.ijccm.org/text.asp?2018/22/10/757/243593
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http://dx.doi.org/10.4103/ijccm.IJCCM_285_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201641PMC
October 2018
5 Reads

Trigeminocardiac Reflex: Case Report and Literature Review of Intraoperative Asystole in Response to Manipulation of the Temporalis Muscle.

World Neurosurg 2019 Feb 3;122:424-427. Epub 2018 Nov 3.

Division of Neurosurgery, Department of Surgery, McMaster University, Hamilton, Ontario, Canada. Electronic address:

Background: The trigeminocardiac reflex is a sudden onset of bradycardia, hypotension, apnea, or gastric hypermotility in response to stimulation of the trigeminal nerve.

Case Description: A 60-year-old female underwent a left orbitozygomatic craniotomy to debulk a large skull base epidermoid cyst compressing the brainstem and cranial nerves. Intraoperatively, retraction of the temporalis muscle consistently produced asystole. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.10.186DOI Listing
February 2019
1 Read

Safety, Tolerability, and Feasibility of Young Plasma Infusion in the Plasma for Alzheimer Symptom Amelioration Study: A Randomized Clinical Trial.

JAMA Neurol 2019 Jan;76(1):35-40

Department of Neurology and Neurological Sciences, Stanford University, Stanford, California.

Importance: Young mouse plasma restores memory in aged mice, but, to our knowledge, the effects are unknown in patients with Alzheimer disease (AD).

Objective: To assess the safety, tolerability, and feasibility of infusions of young fresh frozen plasma (yFFP) from donors age 18 to 30 years in patients with AD.

Design, Setting, And Participants: The Plasma for Alzheimer Symptom Amelioration (PLASMA) study randomized 9 patients under a double-blind crossover protocol to receive 4 once-weekly infusions of either 1 unit (approximately 250 mL) of yFFP from male donors or 250 mL of saline, followed by a 6-week washout and crossover to 4 once-weekly infusions of an alternate treatment. Read More

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http://archneur.jamanetwork.com/article.aspx?doi=10.1001/jam
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http://dx.doi.org/10.1001/jamaneurol.2018.3288DOI Listing
January 2019
9 Reads

Maxillomandibulocardiac reflex in a dog.

Acta Vet Scand 2018 Oct 29;60(1):64. Epub 2018 Oct 29.

Department of Animal Medicine, Production and Health, University of Padua, Viale dell'Università 16, 35020, Legnaro, PD, Italy.

Background: The trigeminocardiac reflex (TCR) is a brainstem reflex that may be observed in anaesthesia during surgical procedures stimulating the intracranial or peripheral portion of the trigeminal nerve. The peripheral TCR is divided into the oculocardiac reflex and the maxillomandibulocardiac reflex based on the affected sensory branches of the trigeminal nerve. In veterinary medicine the oculocardiac reflex has been described, however the maxillomandibulocardiac reflex has never been reported. Read More

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http://dx.doi.org/10.1186/s13028-018-0421-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206717PMC
October 2018
3 Reads

Severe hypokalemia with cardiac arrest as an unusual manifestation of alcoholism.

J Community Hosp Intern Med Perspect 2018 15;8(5):285-291. Epub 2018 Oct 15.

Medicine Department, Pulmonary and Critical Care Division, Interfaith Medical Center, Brooklyn, NY, USA.

: Unhealthy use of alcohol can be associated with serious adverse events. Patients with alcoholism and malnutrition are at high risk for electrolyte disturbances, commonly hypokalemia. Here in we describe a case of alcohol use disorder presented with weakness and subsequently developed cardiac arrest secondary to severe hypokalemia. Read More

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https://www.tandfonline.com/doi/full/10.1080/20009666.2018.1
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http://dx.doi.org/10.1080/20009666.2018.1514943DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197009PMC
October 2018
10 Reads

Unifocal Right-Sided Ablation Treatment for Neurally Mediated Syncope and Functional Sinus Node Dysfunction Under Computed Tomographic Guidance.

Circ Arrhythm Electrophysiol 2018 Sep;11(9):e006604

The Lambe Institute for Translational Medicine and Curam, National University of Ireland, Galway and Saolta University Healthcare Group (W.W.).

Background Biatrial, extensive, and complex ablation strategies have been published for the treatment of neurally mediated syncope, sinus node dysfunction, and functional atrioventricular block. We have developed a less extensive and more specific approach compared with previously published cardioneuroablation strategies, called cardio-neuromodulation. It is based on tailored vagolysis of the sinoatrial node through partial ablation of the anterior right-ganglionated plexus, preferentially through a right-sided approach. Read More

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https://www.ahajournals.org/doi/10.1161/CIRCEP.118.006604
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http://dx.doi.org/10.1161/CIRCEP.118.006604DOI Listing
September 2018
9 Reads

Application of pediatric Appropriate Use Criteria for initial outpatient evaluation of asymptomatic patients with abnormal electrocardiograms.

Congenit Heart Dis 2018 Oct 23. Epub 2018 Oct 23.

Division of Pediatric Cardiology, Department of Pediatrics, Children's Healthcare of Atlanta, Emory University, Atlanta, Georgia.

Introduction: In the pediatric Appropriate Use Criteria (AUC), abnormal electrocardiogram (ECG) in an asymptomatic patient has been rated as an "Appropriate" indication for transthoracic echocardiogram (TTE). We hypothesized that the yield of abnormal findings on TTE for this indication will be low.

Methods: All asymptomatic patients (≤ 18 years) from January 1, 2015 to December 31, 2017 who underwent initial outpatient evaluation at our center and had a TTE ordered for an abnormal ECG, were included. Read More

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http://doi.wiley.com/10.1111/chd.12687
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http://dx.doi.org/10.1111/chd.12687DOI Listing
October 2018
7 Reads

Severe hypothyroidism presenting with supraventricular tachycardia.

Med J Malaysia 2018 Oct;73(5):349-350

Hospital Sultan Haji Ahmad Shah, Pahang, Malaysia.

Thyroid disease is common and can have various systemic manifestations including cardiac diseases. Hypothyroidism is commonly associated with sinus bradycardia, low QRS complexes, prolonged QT interval and conduction blocks but rarely may cause arrhythmias. We present a patient who presented with presyncope and supraventricular tachycardia with severe hypothyroidism. Read More

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October 2018
2 Reads

Study of Rhythm Disturbances in Acute Myocardial Infarction.

J Assoc Physicians India 2018 01;66(1):54-8

Professor, JNMC, Sawangi Wardha, Maharashtra.

Introduction: Cardiac rhythm disturbances are common presentation in acute coronary syndromes and are cause of frequent serious complications in acute myocardial infarction (AMI). However due to availability of early reperfusion therapy and primary angioplasty, arrhythmias have cause a reduction in mortality. Arrhythmias are key events before, during or after the occurrence of acute MI. Read More

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January 2018
20 Reads

The Incremental Benefit of Color Tissue Doppler in Fetal Arrhythmia Assessment.

J Am Soc Echocardiogr 2019 Jan 16;32(1):145-156. Epub 2018 Oct 16.

Fetal and Neonatal Cardiology Program, Department of Pediatrics, Division of Cardiology, Women's & Children's Health Research Institute, University of Alberta, Stollery Children's Hospital, Edmonton, Alberta, Canada. Electronic address:

Background: Accurate fetal arrhythmia (FA) diagnosis is key for effective management. Currently, FA assessment relies on standard echocardiography-based techniques (M mode and spectral Doppler), which require adequate fetal position and cursor alignment to define temporal relationships of mechanical events. Few data exist on the application of color Doppler tissue imaging (c-DTI) in FA assessment. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08947317183044
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http://dx.doi.org/10.1016/j.echo.2018.08.009DOI Listing
January 2019
14 Reads

Human Atrial Arrhythmogenesis and Sinus Bradycardia in -Linked Short QT Syndrome: Insights From Computational Modelling.

Front Physiol 2018 4;9:1402. Epub 2018 Oct 4.

Biological Physics Group, School of Physics and Astronomy, The University of Manchester, Manchester, United Kingdom.

Atrial fibrillation (AF) and sinus bradycardia have been reported in patients with short QT syndrome variant 2 (SQT2), which is underlain by gain-of-function mutations in encoding the α subunit of channels carrying slow delayed rectifier potassium current, . However, the mechanism(s) underlying the increased atrial arrhythmogenesis and impaired cardiac pacemaking activity arising from increased remain unclear. Possible pharmacological interventions of AF in the SQT2 condition also remain to be elucidated. Read More

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http://dx.doi.org/10.3389/fphys.2018.01402DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180159PMC
October 2018
2 Reads

Insights into permanent pacemaker implantation following TAVR in a real-world cohort.

PLoS One 2018 17;13(10):e0204503. Epub 2018 Oct 17.

Clinic for Cardiology & Pneumology, University Medical Center Goettingen, Goettingen, Germany.

Background: Permanent pacemaker implantation (PPI) following TAVR is a frequent post interventional complication and its management remains controversial.

Objective: We sought to elucidate the electrophysiological, procedural, and clinical baseline parameters that are associated with and perhaps predict the need for PPI after TAVR in a heterogeneous-valve-type real-world cohort.

Methods: Overall, 494 patients receiving TAVR at our center from April 2009 to August 2015 were screened. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0204503PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192571PMC
October 2018
13 Reads