7,711 results match your criteria Singapore Medical Journal[Journal]


The effects of gel-based manicure on pulse oximetry.

Singapore Med J 2019 Mar 11. Epub 2019 Mar 11.

Department of Anaesthesiology, Singapore General Hospital, Singapore.

Introduction: Pulse oximetry is the standard monitoring technique of functional oxygen saturation (SpO2). As the use of fingernail polish has been described to alter SpO2 readings, its removal is commonly recommended prior to measurement. Gel-based manicures have gained popularity in recent years due to their attractiveness and longevity. Read More

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http://dx.doi.org/10.11622/smedj.2019031DOI Listing

Relation of blood pressure variability to left ventricular function and arterial stiffness in hypertensive patients.

Singapore Med J 2019 Mar 11. Epub 2019 Mar 11.

Division of Cardiology, Inha University College of Medicine, Incheon, South Korea.

Introduction: Variability of blood pressure (BP) has been reported to be related to worse cardiovascular outcomes. We examined the impact of daytime systolic BP variability on left ventricular (LV) function and arterial stiffness in hypertensive patients.

Methods: Ambulatory BP monitoring (ABPM) and echocardiography were performed in 116 hypertensive patients. Read More

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http://dx.doi.org/10.11622/smedj.2019030DOI Listing

Associated factors of blood transfusion for Caesarean sections in pure placenta praevia pregnancies.

Singapore Med J 2019 Mar 11. Epub 2019 Mar 11.

Department of Obstetrics and Gynaecology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Introduction: This study aimed to evaluate associated factors of blood transfusion for Caesarean sections in pure placenta praevia pregnancies.

Methods: A case-control study was conducted among 405 pregnant women with placenta praevia who underwent Caesarean delivery between August 2004 and December 2013. 135 of the women received blood transfusions. Read More

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http://dx.doi.org/10.11622/smedj.2019029DOI Listing

Efficacy and safety of denosumab compared to bisphosphonates in improving bone strength in postmenopausal osteoporosis: a systematic review.

Singapore Med J 2019 Mar 11. Epub 2019 Mar 11.

Department of Infectious Diseases, Singapore General Hospital, Singapore.

Introduction: Osteoporosis is the main cause of fractures among women after menopause. This study aimed to evaluate the efficacy and safety of denosumab compared to bisphosphonates in treating postmenopausal osteoporosis.

Methods: Databases including PubMed and the Cochrane Central Register of Controlled Trials were systematically searched for randomised controlled trials (RCTs) that directly compared denosumab and bisphosphonates. Read More

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http://dx.doi.org/10.11622/smedj.2019028DOI Listing

Ingrowing toenails in children and adolescents: is nail avulsion superior to nonoperative treatment?

Singapore Med J 2019 Feb;60(2):94-96

Department of Orthopaedic Surgery, KK Women's and Children's Hospital, Singapore.

Introduction: Ingrowing toenail (IGTN) or onychocryptosis is not uncommon in children and adolescents. However, there is a dearth of evidence in the literature on the management of IGTN in this age group. This study aimed to compare the results of nonoperative treatment for IGTN with that of operative treatment among children and adolescents. Read More

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http://dx.doi.org/10.11622/smedj.2018106DOI Listing
February 2019

Developmental assessment: practice tips for primary care physicians.

Singapore Med J 2019 Feb;60(2):57-62

Department of Paediatrics, Child Developmental Service, KK Women's and Children's Hospital, Singapore.

Child development refers to the continuous but predictably sequential biological, psychological and emotional changes that occur in human beings between birth and the end of adolescence. Developmental surveillance should be incorporated into every child visit. Parents play an important role in the child's developmental assessment. Read More

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http://dx.doi.org/10.11622/smedj.2019016DOI Listing
February 2019
2 Reads

Epidemiological and pathophysiological evidence supporting links between obstructive sleep apnoea and Type 2 diabetes mellitus.

Singapore Med J 2019 Feb;60(2):54-56

Department of Respiratory and Critical Care Medicine, Tan Tock Seng Hospital, Singapore.

Obstructive sleep apnoea (OSA) and Type 2 diabetes mellitus (T2DM) are common diseases. The global prevalence of OSA is between 2% and 7% in general population cohorts. The worldwide prevalence of T2DM among adults (aged 20-79 years) was estimated to be 6. Read More

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http://dx.doi.org/10.11622/smedj.2019015DOI Listing
February 2019

Review of magnetic resonance imaging features of complications after anterior cruciate ligament reconstruction.

Singapore Med J 2019 Feb;60(2):63-68

The Orchard Imaging Centre, Singapore.

The anterior cruciate ligament (ACL) is an important stabiliser of the knee and is commonly torn in sports injuries. Common indications for imaging after ACL reconstruction include persistent symptoms, limitation of motion and re-injury. Important postoperative complications include graft failure, impingement, arthrofibrosis and graft degeneration. Read More

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http://dx.doi.org/10.11622/smedj.2019017DOI Listing
February 2019
1 Read

Repair of left ventricular pseudoaneurysm from mitral valve endocarditis.

Singapore Med J 2019 Feb;60(2):105-106

Centre for Cardiothoracic Surgery, Gleneagles Hospital, Singapore.

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http://dx.doi.org/10.11622/smedj.2019020DOI Listing
February 2019
1 Read

Authors' reply.

Singapore Med J 2019 Feb;60(2):104

Research Division, Institute of Mental Health, Singapore.

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http://dx.doi.org/10.11622/smedj.2019019DOI Listing
February 2019

Comment on: Prevalence and correlates of diabetes mellitus and dyslipidaemia in a long-stay inpatient schizophrenia population in Singapore.

Authors:
Mustafa Afifi

Singapore Med J 2019 Feb;60(2):104

College of Health Sciences, Jumeira University, United Arab Emirates.

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http://dx.doi.org/10.11622/smedj.2019018DOI Listing
February 2019
1 Read

Comment on: Medication-related osteonecrosis of the jaw in osteoporotic patients: prevention and management.

Singapore Med J 2019 01;60(1):52

Department of Restorative Dentistry, Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia.

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http://dx.doi.org/10.11622/smedj.2019006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351692PMC
January 2019
2 Reads

Comment on: Understanding Singaporean medical students' stress and coping.

Authors:
Ian Jun Yan Wee

Singapore Med J 2019 01;60(1):53

Yong Loo Lin School of Medicine, National University of Singapore.

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http://dx.doi.org/10.11622/smedj.2019007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351690PMC
January 2019
1 Read

Jonas Salk (1914-1995): A vaccine against polio.

Singapore Med J 2019 Jan;60(1):9-10

Research carried out during medical residency, John A Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, USA.

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http://dx.doi.org/10.11622/smedj.2019002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351694PMC
January 2019

Clinics in diagnostic imaging (194). SVC aneurysm.

Singapore Med J 2019 Jan;60(1):17-21

Department of Diagnostic Radiology, Changi General Hospital, Singapore.

A 68-year-old woman presented with weight loss of 7 kg over two years. Clinical examination revealed no specific abnormality and the patient was otherwise asymptomatic. Chest radiography performed to screen for malignancy revealed a soft tissue opacity projected over the mediastinum. Read More

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http://dx.doi.org/10.11622/smedj.2019005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351698PMC
January 2019
1 Read

Approach to infantile colic in primary care.

Singapore Med J 2019 Jan;60(1):12-16

Department of Family Medicine, National University Health System, Singapore.

Infantile colic is a common self-limiting condition that causes significant distress to parents and caregivers. There is no clear cause, gold standard remedy or preventative action. The role of the family physician is to rule out sinister causes while providing counselling and reassurance for parents. Read More

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http://dx.doi.org/10.11622/smedj.2019004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351691PMC
January 2019
1 Read

Parental knowledge and beliefs on the use of child car restraints in Singapore: a qualitative study.

Singapore Med J 2019 Feb 18. Epub 2019 Feb 18.

Department of Emergency Medicine, KK Women's and Children's Hospital, Singapore.

Introduction: Road traffic injuries and fatalities represent a significant public health problem. In Singapore, compliance with appropriate child car restraints (CCRs) is poor. We aimed to understand parental knowledge, beliefs and barriers regarding the use of CCRs. Read More

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http://dx.doi.org/10.11622/smedj.2019023DOI Listing
February 2019

High-sensitivity troponin T and long-term adverse cardiac events among patients presenting with suspected acute coronary syndrome in Singapore.

Singapore Med J 2019 Feb 18. Epub 2019 Feb 18.

Cardiovascular Research Institute, Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

Introduction: Prognostic thresholds for 30-day major adverse cardiovascular events (MACE) have been studied for high-sensitivity troponin T (hsTnT) in patients with suspected acute coronary syndrome (ACS), but there is limited data on the prognostic performance of hsTnT for one-year MACE.

Methods: We prospectively measured hsTnT (in ng/mL to up to two decimal places) at 0, 2 and 7 hours for patients presenting with symptoms suggestive of ACS to our emergency department from March 2010 to April 2013. We assessed the prognostic performance of hsTnT cut-offs for 30-day and one-year MACE, and the utility of delta-hsTnT in predicting MACE. Read More

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http://dx.doi.org/10.11622/smedj.2019013DOI Listing
February 2019
2 Reads
0.634 Impact Factor

Endoscopic submucosal dissection of colorectal neoplasms: an audit of its safety and efficacy in a single tertiary centre in Singapore.

Singapore Med J 2019 Feb 18. Epub 2019 Feb 18.

Department of Gastroenterology and Hepatology, Changi General Hospital, Singapore.

Introduction: Endoscopic submucosal dissection (ESD) provides a higher en bloc and R0 resection rate than endoscopic mucosal resection (EMR). Colorectal ESD is not widely used because of its technical difficulty and risk of complications, especially for right-sided colonic lesions. We audited the clinical outcomes of our initial experience with colorectal ESD. Read More

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http://dx.doi.org/10.11622/smedj.2019022DOI Listing
February 2019
1 Read

Cholesterol goal achievement and lipid-lowering therapy in patients with stable or acute coronary heart disease in Singapore: results from the Dyslipidemia International Study II.

Singapore Med J 2019 Feb 18. Epub 2019 Feb 18.

Herzzentrum Ludwigshafen, Cardiology, Stiftung Institut für Herzinfarktforschung, Ludwigshafen, Germany.

Introduction: Dyslipidaemia is a major risk factor for coronary heart disease (CHD). There is a lack of data on the extent of lipid abnormalities and lipid-lowering therapy (LLT) in Singapore.

Methods: The Dyslipidemia International Study (DYSIS) II was a multinational observational study of patients with stable CHD and hospitalised patients with an acute coronary syndrome (ACS). Read More

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http://dx.doi.org/10.11622/smedj.2019021DOI Listing
February 2019

Vulvar basal cell carcinoma: clinical features and treatment outcomes from a tertiary-care centre.

Singapore Med J 2019 Feb 18. Epub 2019 Feb 18.

Department of Pathology and Laboratory Medicine, KK Women's and Children's Hospital, Singapore.

We retrospectively reviewed the clinical features, management and outcomes of patients diagnosed with basal cell carcinoma (BCC) of the vulva at the Gynaecological Cancer Centre, KK Women's and Children's Hospital, Singapore, between 1 January 2000 and 28 February 2014. Patients with vulvar BCC were identified from the cancer registry, and their medical records reviewed and analysed. A total of 11 patients with vulvar BCC were identified. Read More

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http://dx.doi.org/10.11622/smedj.2019014DOI Listing
February 2019
1 Read

Knowledge and practice of colorectal cancer screening in an urban setting: cross-sectional survey of primary care physicians in government clinics in Malaysia.

Singapore Med J 2019 Jan 15. Epub 2019 Jan 15.

University of Malaya Primary Care Research Group, Department of Primary Care Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

Introduction: Colorectal cancer (CRC) was the third most commonly diagnosed cancer worldwide in 2008 (1.23 million cases, 9.7%). Read More

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http://dx.doi.org/10.11622/smedj.2019011DOI Listing
January 2019

Bicycle injuries among the paediatric population at an emergency department in Singapore.

Singapore Med J 2019 Jan 15. Epub 2019 Jan 15.

Children's Emergency, KK Women's and Children's Hospital, Singapore.

Introduction: Bicycles injuries are the leading cause of emergency department visits among all recreational activities and have been established as a significant worldwide public health burden. The purpose of this retrospective study was to describe the epidemiology and patterns of paediatric bicycle-related injuries in Singapore.

Methods: This was a single-centre retrospective study based on data collected from a trauma registry between 2011 and 2016. Read More

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http://www.smj.org.sg/sites/default/files/OA-2017-096-epub.p
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http://dx.doi.org/10.11622/smedj.2019009DOI Listing
January 2019
5 Reads

Can we understand population healthcare needs using electronic medical records?

Singapore Med J 2019 Jan 15. Epub 2019 Jan 15.

Programme in Health Services and Systems Research, Duke-NUS Medical School, Singapore.

Introduction: The identification of population-level healthcare needs using hospital electronic medical records (EMRs) is a promising approach for the evaluation and development of tailored healthcare services. Population segmentation based on healthcare needs may be possible using information on health and social service needs from EMRs. However, it is currently unknown if EMRs from restructured hospitals in Singapore provide information of sufficient quality for this purpose. Read More

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http://www.smj.org.sg/sites/default/files/OA-2017-079-epub.p
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http://dx.doi.org/10.11622/smedj.2019012DOI Listing
January 2019
4 Reads
0.634 Impact Factor

Initial experience of laparoscopic right hemicolectomy with complete mesocolic excision in Singapore: a case series.

Singapore Med J 2019 Jan 15. Epub 2019 Jan 15.

One Surgical Clinic and Surgery, Mount Elizabeth Novena Specialist Centre, Singapore.

Introduction: Laparoscopic colorectal surgery is increasingly performed worldwide due to its multiple advantages over traditional open surgery. In the surgical treatment of right-sided colonic tumours, the latest technique is laparoscopic right hemicolectomy with complete mesocolic excision (lapCME), which aims to lower the rate of local recurrence and maximise survival as compared to standard laparoscopic right hemicolectomy (lapS).

Methods: We conducted a retrospective analysis of our initial experience with lapCME in Singapore General Hospital between 2012 and 2015. Read More

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http://dx.doi.org/10.11622/smedj.2019008DOI Listing
January 2019
2 Reads

Colonic stenting for malignant large bowel obstruction is safe and effective: a single-surgeon experience.

Singapore Med J 2019 Jan 15. Epub 2019 Jan 15.

Department of Colorectal Surgery, Singapore General Hospital, Singapore.

Introduction: Self-expanding metal stents (SEMS) can be used as a bridge to surgery (BTS) or for palliation in the treatment of malignant large bowel obstruction. This case series evaluates the short-term outcomes of SEMS and success rates over time.

Methods: A total of 75 consecutive patients who underwent colonic stenting for malignant colonic obstruction over a period of six years were included. Read More

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http://dx.doi.org/10.11622/smedj.2019010DOI Listing
January 2019
1 Read

A practical clinical approach to liver fibrosis.

Singapore Med J 2018 12;59(12):628-633

Department of Gastroenterology and Hepatology, Changi General Hospital, Singapore.

Liver fibrosis is a slow, insidious process involving accumulation of extracellular matrix protein in the liver. The stage of liver fibrosis in chronic liver disease (CLD) determines overall morbidity and mortality; the higher the stage, the worse the prognosis. Noninvasive composite scores can be used to determine whether patients with CLD have significant or advanced fibrosis. Read More

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http://www.smj.org.sg/article/practical-clinical-approach-li
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http://dx.doi.org/10.11622/smedj.2018145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301869PMC
December 2018
7 Reads
0.634 Impact Factor

Knowledge of orthopaedic implant costs and healthcare schemes among orthopaedic residents.

Singapore Med J 2018 12;59(12):616-618

Department of Orthopaedic Surgery, Tan Tock Seng Hospital, Singapore.

There is a paucity of available research on knowledge of orthopaedic implant costs and healthcare schemes among orthopaedic residents. With the rising healthcare costs in Singapore, it is imperative for residents, who are the future surgeons, to understand these issues in order to provide proper counselling and cost-effective management. This study aimed to quantify how accurately they understood these issues and determine if senior residents had better knowledge given their increased experience. Read More

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http://dx.doi.org/10.11622/smedj.2018143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301878PMC
December 2018
1 Read

Winds of change in medical education in Singapore: what does the future hold?

Singapore Med J 2018 12;59(12):614-615

Division of Infectious Diseases, Department of Medicine, National University Health System, Singapore.

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http://dx.doi.org/10.11622/smedj.2018142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301870PMC
December 2018

Clinics in diagnostic imaging (193). Sporadic Creutzfeldt-Jakob disease (sCJD).

Singapore Med J 2018 12;59(12):634-641

Department of Diagnostic Radiology, Division of Radiological Sciences, Singapore General Hospital, Singapore.

A 68-year-old man presented with a three-week history of rapidly progressive dementia, gait ataxia and myoclonus. Subsequent electroencephalography showed periodic sharp wave complexes, and cerebrospinal fluid assay revealed the presence of a 14-3-3 protein. A probable diagnosis of sporadic Creutzfeldt-Jakob disease was made, which was further supported by magnetic resonance (MR) imaging of the brain showing asymmetric signal abnormality in the cerebral cortices and basal ganglia. Read More

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http://dx.doi.org/10.11622/smedj.2018146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301874PMC
December 2018
1 Read
0.634 Impact Factor

Teaching the millennial radiology resident: applying a five-step 'microskills' pedagogy.

Singapore Med J 2018 12;59(12):619-621

Department of Diagnostic Radiology, Singapore General Hospital, Singapore.

Radiology is a unique medical specialty that focuses on image interpretation and report generation with limited patient contact. Resident read-out sessions with teaching are a quintessential part of reporting workflow practices in teaching institutions. However, most radiologist-educators do not have formal training in teaching and learning experiences vary. Read More

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http://dx.doi.org/10.11622/smedj.2018144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301868PMC
December 2018

Prevalence of growth and endocrine disorders in Malaysian children with transfusion-dependent thalassaemia.

Singapore Med J 2018 Dec 17. Epub 2018 Dec 17.

Department of Paediatrics, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia.

Introduction: Endocrine dysfunction due to iron overload secondary to frequent blood transfusions is a common complication in children with transfusion-dependent thalassaemia (TDT). We ascertained the prevalence of endocrine dysfunction in children with TDT seen in a hospital setting in Malaysia.

Methods: We reviewed all patients with TDT who had ≥ 8 blood transfusions per year. Read More

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http://www.smj.org.sg/sites/default/files/OA-2016-339-epub.p
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http://dx.doi.org/10.11622/smedj.2018155DOI Listing
December 2018
8 Reads
0.634 Impact Factor

Short-term outcomes of outpatient surgery for total knee arthroplasty.

Singapore Med J 2018 Dec 17. Epub 2018 Dec 17.

Orthopaedics and Traumatology Department, Private Medicabil Hospital, Bursa, Turkey.

Introduction: We have developed an accelerated clinical pathway involving outpatient surgery for patients undergoing total knee arthroplasty (TKA) who are healthy enough for early discharge.

Methods: Between March 2014 and April 2015, 89 TKAs were performed at a single institution by a single orthopaedic surgeon. 31 patients met the inclusion criteria for the study. Read More

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http://dx.doi.org/10.11622/smedj.2018157DOI Listing
December 2018
1 Read

Optimal liver stiffness measurement values for the diagnosis of significant fibrosis and cirrhosis in chronic liver disease in Singapore.

Singapore Med J 2018 Dec 17. Epub 2018 Dec 17.

Department of Gastroenterology and Hepatology, Singapore General Hospital, Singapore.

Introduction: Despite the widespread use of transient elastography for non-invasive assessment of liver fibrosis, the optimal cut-off liver stiffness measurement (LSM) values remain unclear. This study aimed to validate the optimal cut-off LSM values for significant fibrosis and cirrhosis in patients with chronic liver disease (CLD).

Methods: Prospective multicentre data of CLD patients who underwent paired liver biopsy and LSM was analysed to determine the optimal cut-off LSM values for predicting significant fibrosis (METAVIR F ≥ 2) and cirrhosis (METAVIR F4). Read More

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http://dx.doi.org/10.11622/smedj.2018156DOI Listing
December 2018

Safety and efficacy of SpyGlass cholangiopancreatoscopy in routine clinical practice in a regional Singapore hospital.

Singapore Med J 2018 Dec 17. Epub 2018 Dec 17.

Department of Gastroenterology and Hepatology, Changi General Hospital, Singapore.

Introduction: This study examined the efficacy and safety of cholangiopancreatoscopy via the SpyGlass™ system in routine clinical practice.

Methods: The clinical data of endoscopic retrograde cholangiopancreatography (ERCP) performed in a regional hospital from January 2013 to November 2016 was retrieved from an electronic database and reviewed. All patients who had undergone SpyGlass cholangiopancreatoscopy were enrolled. Read More

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http://www.smj.org.sg/sites/default/files/OA-2017-028-epub.p
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http://dx.doi.org/10.11622/smedj.2018158DOI Listing
December 2018
9 Reads

A wolf in sheep's clothing: a benign perineurioma-like lesion that is not what it seems.

Singapore Med J 2018 Nov;59(11):608-610

Department of Anatomical Pathology, Singapore General Hospital, Singapore.

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http://dx.doi.org/10.11622/smedj.2018137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250761PMC
November 2018

The empowerment of all modalities against cancer.

Singapore Med J 2018 11;59(11):560-561

Division of Medical Oncology, National Cancer Centre Singapore, Singapore.

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http://dx.doi.org/10.11622/smedj.2018133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250756PMC
November 2018
1 Read

Automation and productivity in the clinical laboratory: experience of a tertiary healthcare facility.

Singapore Med J 2018 Nov;59(11):597-601

Department of Clinical Pathology, Singapore General Hospital, Singapore.

Clinical laboratories for in vitro diagnostics are facing pressure to preserve cost control while providing better services through new initiatives. Laboratory automation is a partial answer to this problem, having come a long way from the early days of clinical laboratory testing. The journey and implementation of automation in the Singapore General Hospital's Clinical Biochemistry Laboratory has allowed for sustained performance in the light of increasing workload and service commitments amid an evolving healthcare environment. Read More

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http://dx.doi.org/10.11622/smedj.2018136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250760PMC
November 2018

Multivessel coronary artery spasm in pericarditis.

Singapore Med J 2018 Nov;59(11):611-613

Department of Cardiology, National University Heart Centre, Singapore.

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http://dx.doi.org/10.11622/smedj.2018138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250754PMC
November 2018
2 Reads

Clinics in diagnostic imaging (192). Flexion teardrop fracture.

Singapore Med J 2018 Nov;59(11):562-566

Department of Diagnostic Radiology, Singapore General Hospital, Singapore.

An 82-year-old woman presented with neck pain and bilateral upper limb paraesthesia after sustaining an unwitnessed fall at home the day before. Physical examination revealed tenderness over the C4-6 region but no evidence of step deformity or neurological deficit. Magnetic resonance imaging of the cervical spine revealed multiple small fractures at the anteroinferior endplate corners of the C3, C5 and C6 vertebrae with focal kyphosis and marrow oedema at these levels, as well as associated disruption of the anterior longitudinal ligament and central spinal canal stenosis. Read More

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http://dx.doi.org/10.11622/smedj.2018134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250755PMC
November 2018
1 Read

Managing polycystic ovary syndrome in primary care.

Singapore Med J 2018 Nov;59(11):567-571

Department of Endocrinology, Changi General Hospital, Singapore.

Polycystic ovary syndrome (PCOS) presents with a spectrum of conditions resulting from androgen excess, anovulation and metabolic syndrome. Patients with PCOS may see their primary care physicians for various presentations, including hirsutism, acne, menstrual irregularities, infertility, obesity, and psychiatric disorders such as anxiety and depression. Management of these patients should include screening for Type 2 diabetes mellitus, dyslipidaemia and hypertension. Read More

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http://dx.doi.org/10.11622/smedj.2018135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250763PMC
November 2018
5 Reads

Midnight salivary cortisol for the diagnosis of Cushing's syndrome in a Chinese population.

Singapore Med J 2018 Nov 29. Epub 2018 Nov 29.

Division of Endocrinology and Metabolism, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan ROC.

Introduction: Cushing's syndrome is defined as chronic excess free cortisol in circulation. According to recent studies, midnight salivary cortisol is an accurate and non-stress method for screening and diagnosing Cushing's syndrome. However, there is limited data on midnight salivary cortisol for diagnosing Cushing's syndrome in the Chinese population. Read More

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http://dx.doi.org/10.11622/smedj.2018154DOI Listing
November 2018
11 Reads

Percutaneous pulmonary valve implantation as an alternative to repeat open-heart surgery for patients with pulmonary outflow obstruction: a reality in Singapore.

Singapore Med J 2018 Nov 29. Epub 2018 Nov 29.

Department of Pediatrics, National University of Singapore, Singapore.

Right ventricle to pulmonary artery (RV-PA) conduits have been used for the surgical repair of congenital heart defects. These conduits frequently become stenosed or develop insufficiency with time, necessitating reoperations. Percutanous pulmonary valve implantation (PPVI) can delay the need for repeated surgeries in patients with congenital heart defects and degenerated RV-PA conduits. Read More

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http://www.smj.org.sg/sites/default/files/CS-2017-047-epub.p
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http://dx.doi.org/10.11622/smedj.2018141DOI Listing
November 2018
8 Reads

Improving prescribing for older patients - 'Yes S-I-R-E!'

Singapore Med J 2018 Nov 29. Epub 2018 Nov 29.

Department of Geriatric Medicine, Changi General Hospital, Singapore.

Introduction: Polypharmacy and inappropriate prescribing are associated with negative health outcomes in the elderly. Several prescribing tools have been developed to assess medication appropriateness. Explicit (criteria-based) tools often do not take into account patients' preferences and comorbidities, and have little room for individualised clinical judgement. Read More

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http://dx.doi.org/10.11622/smedj.2018153DOI Listing
November 2018
10 Reads

Effects of proton pump inhibitor on the human gut microbiome profile in multi-ethnic groups in Singapore.

Singapore Med J 2018 Nov 29. Epub 2018 Nov 29.

Department of Gastroenterology and Hepatology, Changi General Hospital, Singapore.

Introduction: The objectives of this study were to examine the effects of ethnicity, gender, and a proton pump inhibitor (PPI), omeprazole, on the human gut microbiome. PPIs are commonly used for the treatment of acid-related disorders. We hypothesised that PPI therapy might perturb microbial communities and alter the gut microbiome. Read More

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http://dx.doi.org/10.11622/smedj.2018152DOI Listing
November 2018
6 Reads

Amblyopia therapy in Asian children: factors affecting visual outcome and parents' perception of children's attitudes towards amblyopia treatment.

Singapore Med J 2018 Nov 29. Epub 2018 Nov 29.

Paediatric Ophthalmology, KK Women's and Children's Hospital, Singapore.

Introduction: Amblyopia treatment in the form of glasses and/or patching in children poses a great challenge to parents. This study aimed to assess the factors that influence visual outcome in amblyopia and children's perception towards treatment.

Methods: 180 children (aged 3. Read More

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http://dx.doi.org/10.11622/smedj.2018151DOI Listing
November 2018
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