92,385 results match your criteria Singapore Medical Journal[Journal]


Questionnaire-Based Survey on Management of Ulcerative Colitis-Associated Cancer in East Asian Countries.

Digestion 2018 Dec 14;99(1):86-94. Epub 2018 Dec 14.

Sino United Health Clinic, Gopher Medical Center, Rui Jing Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Background/aims: To elucidate the current management of ulcerative colitis (UC)-associated cancer, a questionnaire-based survey was conducted to gather current opinions on colitis-associated cancer in different East Asian countries.

Methods: The questionnaire, based on physicians, contains 9 questions focused on UC management and cancer surveillance. In addition, the questionnaire based on neoplastic cases, which contains 17 questions, was collected and analyzed. Read More

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December 2018

PsAID12 Provisionally Endorsed at OMERACT 2018 as Core Outcome Measure to Assess Psoriatic Arthritis-specific Health-related Quality of Life in Clinical Trials.

J Rheumatol 2018 Dec 15. Epub 2018 Dec 15.

From the Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore; Department of Medicine, Duke University School of Medicine, Durham, North Carolina; Kezar Life Sciences, South San Francisco; Division of Immunology, Stanford University, Palo Alto, California; Rheumatology Research, Swedish Medical Center and University of Washington School of Medicine, Seattle, Washington; Global Patient Outcomes and Real World Evidence, Eli Lilly and Co., Indianapolis, Indiana; University of Pennsylvania, Philadelphia, Pennsylvania; Department of Dermatology, University of Utah, Salt Lake City, Utah, USA; Royal Prince Alfred Hospital Medical Centre, Sydney, Australia; Department of Rheumatology and Immunology, Singapore General Hospital, Singapore; Royal National Hospital for Rheumatic Diseases, Bath; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK; Musculoskeletal Statistics Unit: The Parker Institute, Bispebjerg and Frederiksberg Hospital, Copenhagen; Department of Rheumatology, Odense University Hospital, Odense, Denmark; Sorbonne Université; Rheumatology Department, Pitié Salpêtrière Hospital, AP-HP, Paris, France; VU Medical Centre, Amsterdam, the Netherlands; Global Medical Affairs, Pfizer Inc., Montreal, Quebec; Clinical Epidemiology Program, Ottawa Hospital Research Institute; Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; Musculoskeletal Health and Outcomes Research, St. Michael's Hospital and Institute for Work and Health; Department of Occupational Science and Occupational Therapy, Rehabilitation Sciences Institute, Institute for Health Policy Management and Evaluation, University of Toronto; University of Toronto; Krembil Research Institute; Psoriatic Arthritis Program, University Health Network, Toronto, Ontario, Canada; Department of Rheumatology, St. Vincent's University Hospital and Conway Institute for Biomolecular Research, University College Dublin, Dublin, Ireland. AMO is a Jerome L. Greene Foundation Scholar and is supported in part by a research grant from the US National Institute of Arthritis and Musculoskeletal and Skin Diseases of the US National Institutes of Health under award number P30-AR070254 (Core B), a Rheumatology Research Foundation Scientist Development award, and a Staurulakis Family Discovery award. A.M. Orbai, MD, MHS, Division of Rheumatology, Johns Hopkins University School of Medicine; R. Holland, MB, ChB, Royal Prince Alfred Hospital Medical Centre; Y.Y. Leung, MD, PhD, Department of Rheumatology and Immunology, Singapore General Hospital; W. Tillett, BSc, MBChB, PhD, MRCP, Royal National Hospital for Rheumatic Diseases; N. Goel, MD, Patient Research Partner, Department of Medicine, Duke University School of Medicine, and Kezar Life Sciences; R. Christensen, BSc, MSc, PhD, Professor of Biostatistics and Clinical Epidemiology, and Musculoskeletal Statistics Unit: The Parker Institute, Bispebjerg and Frederiksberg Hospital, and Department of Rheumatology, Odense University Hospital; N. McHugh, MBChB, MD, FRCP, FRCPath, Royal National Hospital for Rheumatic Diseases; L. Gossec, MD, PhD, Sorbonne Université, and Rheumatology Department, Pitié Salpêtrière Hospital, AP-HP; M. de Wit, PhD, Patient Research Partner, VU Medical Centre; P. Højgaard, MD, The Parker Institute, Bispebjerg and Frederiksberg Hospital; L.C. Coates, MBChB, PhD, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford; P.J. Mease, MD, Rheumatology Research, Swedish Medical Center and University of Washington School of Medicine; J. Birt, PharmD, Global Patient Outcomes and Real World Evidence, and Eli Lilly and Co.; L. Fallon, PhD, Global Medical Affairs, Pfizer Inc.; O. FitzGerald, MD, FRCPI, FRCP(UK), Newman Clinical Research Professor, Department of Rheumatology, St. Vincent's University Hospital, and Conway Institute for Biomolecular Research, University College Dublin; A. Ogdie, MD, MSCE, University of Pennsylvania; B. Shea, PhD, Clinical Epidemiology Program, Ottawa Hospital Research Institute, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; V. Strand, MD, Division of Immunology, Stanford University; K. Callis Duffin, MD, Department of Dermatology, University of Utah; P. Tugwell, Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, and Clinical Epidemiology Program, Ottawa Hospital Research Institute; D. Beaton, BScOT, PhD, Musculoskeletal Health and Outcomes Research, St. Michael's Hospital and Institute for Work and Health, and Department of Occupational Science and Occupational Therapy, Rehabilitation Sciences Institute, and the Institute for Health Policy Management and Evaluation, University of Toronto; D.D. Gladman, MD, FRCPC, Professor of Medicine, University of Toronto, and Senior Scientist, Krembil Research Institute, and Director, Psoriatic Arthritis Program, University Health Network. Address correspondence to Dr. A.M. Orbai, MD, MHS, Assistant Professor of Medicine, Rheumatology, Director Psoriatic Arthritis Program, Johns Hopkins University School of Medicine, Division of Rheumatology, 5200 Eastern Ave., MFL Center Tower Suite 4100, Baltimore, Maryland 21224, USA. E-mail: Accepted for publication November 6, 2018.

Objective: The Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) and Outcome Measures in Rheumatology (OMERACT) psoriatic arthritis (PsA) working group is developing a Core Outcome Measurement Set for PsA clinical trials [randomized controlled trials (RCT) and longitudinal observational studies (LOS)] using the OMERACT Filter 2.1 instrument selection algorithm. Our objective was to assess the Psoriatic Arthritis Impact of Disease questionnaire (PsAID12) for the measurement of the core domain PsA-specific health-related quality of life (HRQOL). Read More

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December 2018
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Mechanical regulation of genome architecture and cell-fate decisions.

Authors:
G V Shivashankar

Curr Opin Cell Biol 2018 Dec 13;56:115-121. Epub 2018 Dec 13.

Mechanobiology Institute, National University of Singapore, Singapore & FIRC Institute of Molecular Oncology (IFOM), Milan, Italy. Electronic address:

Landmark experiments in vitro showed that somatic cells can be reprogrammed to stem-cells by the constitutive expression of particular transcription factors. However, in vivo cells naturally exhibit de-differentiation and trans-differentiation programs, thereby suggesting that the signals from the local mechanical microenvironment may be sufficient to induce stem-cell state transitions. In this review, we discuss recent evidence for the biophysical regulation of genome architecture and nuclear programs. Read More

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December 2018

CRISPR/Cas9 deletions in a conserved exon of Distal-less generates gains and losses in a recently acquired morphological novelty in flies.

iScience 2018 Dec 1;10:222-233. Epub 2018 Dec 1.

Department of Biological Sciences, National University of Singapore, Singapore, Singapore. Electronic address:

Distal-less has been repeatedly co-opted for the development of many novel traits. Here, we document its curious role in the development of a novel abdominal appendage ("sternite brushes") in sepsid flies. CRISPR/Cas9 deletions in the homeodomain result in losses of sternite brushes, demonstrating that Distal-less is necessary for their development. Read More

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December 2018

Uncovering metastability and disassembly hotspots in whole viral particles.

Prog Biophys Mol Biol 2018 Dec 13. Epub 2018 Dec 13.

Department of Biological Sciences, National University of Singapore, 117543, Singapore. Electronic address:

Viruses are metastable macromolecular assemblies that toggle between multiple conformational states through molecular rearrangements that are critical for mediating viral host entry. Viruses respond to different host specific environmental cues to form disassembly intermediates for the eventual release of genomic material required for replication. Although static snapshots of these intermediates have been captured through structural techniques such as X-ray crystallography and cryo-EM, the mechanistic details of these conformational rearrangements underpinning viral metastability have been poorly understood. Read More

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December 2018

Modification of the bone marrow MSC population in a xenograft model of early multiple myeloma.

Biochem Biophys Res Commun 2018 Dec 12. Epub 2018 Dec 12.

Cancer Science Institute of Singapore, Centre for Translational Medicine, National University of Singapore, 14 Medical Drive, #12-01, 117599, Singapore; International Research Center for Medical Sciences, Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto City, 860-0811, Japan. Electronic address:

Multiple myeloma (MM) is a hematological malignancy characterized by clonal proliferation of abnormal plasma cells. MM dysregulates the homeostasis of the bone niche cells like osteoclasts and osteoblasts, responsible for the bone maintenance leading to bone loss and hypercalcemia, as well as the normal immune cells leading to immunodeficiency and anemia. Osteoblasts are part of the cell population differentiating from mesenchymal stem cells (MSC). Read More

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December 2018

Heat transfer statistics in mixed quantum-classical systems.

J Chem Phys 2018 Dec;149(22):224104

Department of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, Canada.

The modelling of quantum heat transfer processes at the nanoscale is crucial for the development of energy harvesting and molecular electronic devices. Herein, we adopt a mixed quantum-classical description of a device, in which the open subsystem of interest is treated quantum mechanically and the surrounding heat baths are treated in a classical-like fashion. By introducing such a mixed quantum-classical description of the composite system, one is able to study the heat transfer between the subsystem and bath from a closed system point of view, thereby avoiding simplifying assumptions related to the bath time scale and subsystem-bath coupling strength. Read More

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December 2018

Development of Nanoparticles for Drug Delivery to Brain Tumor: The Effect of Surface Materials on Penetration into Brain Tissue.

J Pharm Sci 2018 Dec 12. Epub 2018 Dec 12.

Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore, 117585, Singapore. Electronic address:

Surface modified PLGA nanoparticles were fabricated via nanoprecipitation for obtaining therapeutic concentration of paclitaxel (PTX) in brain tumor. The cellular uptake and cytotoxicity of NPs were evaluated on C6 glioma cells in vitro and BALB/c mice were used to study the brain penetration and bio-distribution upon intravenous administration. Results showed that by finely tuning nanoprecipitation parameters, PLGA nanoparticles coated with surfactants with a size around 150nm could provide a sustained release of PTX for >2 weeks. Read More

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December 2018
1 Read

Multidisciplinary team meetings - challenges of implementation science.

Nat Rev Clin Oncol 2018 Dec 14. Epub 2018 Dec 14.

Division of Radiation Oncology, National Cancer Centre, Singapore, Singapore.

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December 2018

Comparison of macronutrient content in human milk measured by mid-infrared human milk analyzer and reference methods.

J Perinatol 2018 Dec 14. Epub 2018 Dec 14.

Nestlé Research, Vers-chez-les Blanc, P.O. Box 44, 1000, Lausanne 26, Switzerland.

Objective: The study aims at evaluating mid-infrared human milk analyzer (HMA) accuracy and precision, in human milk (HM).

Study Design: Röse-Gottlieb, high-performance anion exchange chromatography-pulsed amperometric detection (HPAEC-PAD), Kjeldahl and amino acid analysis (AA) were selected as references for total fat, lactose and total protein determination.

Results: No significant difference was observed in lactose content between HMA and HPAEC-PAD. Read More

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December 2018

Female adipose tissue-specific Bscl2 knockout mice develop only moderate metabolic dysfunction when housed at thermoneutrality and fed a high-fat diet.

Sci Rep 2018 Dec 14;8(1):17863. Epub 2018 Dec 14.

The Rowett Institute, University of Aberdeen, Aberdeen, UK.

Mutations affecting the BSCL2 gene cause the most severe form of congenital generalised lipodystrophy. Affected individuals almost completely lack adipose tissue and suffer from severe diabetes and metabolic complications. Likewise, mice lacking Bscl2 in all tissues have dramatically reduced adipose mass, glucose intolerance and hyperinsulinaemia. Read More

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December 2018

Neonatal orbital swelling due to intracranial teratoma.

Arch Dis Child Fetal Neonatal Ed 2018 Dec 14. Epub 2018 Dec 14.

Department of Paediatric Medicine, KK Women's and Children's Hospital, Singapore, Singapore.

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December 2018

MS/MS-Based Molecular Networking Approach for the Detection of Aplysiatoxin-Related Compounds in Environmental Marine Cyanobacteria.

Mar Drugs 2018 Dec 13;16(12). Epub 2018 Dec 13.

Natural Sciences and Science Education, National Institute of Education, Nanyang Technological University, Singapore 637616, Singapore.

Certain strains of cyanobacteria produce a wide array of cyanotoxins, such as microcystins, lyngbyatoxins and aplysiatoxins, that are associated with public health issues. In this pilot study, an approach combining LC-MS/MS and molecular networking was employed as a rapid analytical method to detect aplysiatoxins present in four environmental marine cyanobacterial samples collected from intertidal areas in Singapore. Based on 16S-ITS rRNA gene sequences, these filamentous cyanobacterial samples collected from Pulau Hantu were determined as , sp. Read More

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December 2018

Biosynthetic Oligoclonal Antivenom (BOA) for Snakebite and Next-Generation Treatments for Snakebite Victims.

Toxins (Basel) 2018 Dec 13;10(12). Epub 2018 Dec 13.

Department of Biotechnology and Biomedicine, Technical University of Denmark, DK-2800 Kongens Lyngby, Denmark.

Snakebite envenoming is a neglected tropical disease that each year claims the lives of 80,000⁻140,000 victims worldwide. The only effective treatment against envenoming involves intravenous administration of antivenoms that comprise antibodies that have been isolated from the plasma of immunized animals, typically horses. The drawbacks of such conventional horse-derived antivenoms include their propensity for causing allergenic adverse reactions due to their heterologous and foreign nature, an inability to effectively neutralize toxins in distal tissue, a low content of toxin-neutralizing antibodies, and a complex manufacturing process that is dependent on husbandry and procurement of snake venoms. Read More

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December 2018
1 Read

Structure of a (3+1) hybrid G-quadruplex in the PARP1 promoter.

Nucleic Acids Res 2018 Dec 15. Epub 2018 Dec 15.

School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore.

Poly (ADP-ribose) polymerase 1 (PARP1) has emerged as an attractive target for cancer therapy due to its key role in DNA repair processes. Inhibition of PARP1 in BRCA-mutated cancers has been observed to be clinically beneficial. Recent genome-mapping experiments have identified a non-canonical G-quadruplex-forming sequence containing bulges within the PARP1 promoter. Read More

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December 2018
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Novel endotypes in heart failure: effects on guideline-directed medical therapy.

Eur Heart J 2018 Dec 13. Epub 2018 Dec 13.

Department of Cardiology, University of Groningen, Hanzeplein 1, Groningen, the Netherlands.

Aims: We sought to determine subtypes of patients with heart failure (HF) with a distinct clinical profile and treatment response, using a wide range of biomarkers from various pathophysiological domains.

Methods And Results: We performed unsupervised cluster analysis using 92 established cardiovascular biomarkers to identify mutually exclusive subgroups (endotypes) of 1802 patients with HF and reduced ejection fraction (HFrEF) from the BIOSTAT-CHF project. We validated our findings in an independent cohort of 813 patients. Read More

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December 2018

Two Extraordinary Sellar Neuronal Tumors: Literature Review and Comparison of Clinicopathologic Features.

Am J Clin Pathol 2018 Dec 14. Epub 2018 Dec 14.

Department of Pathology, Duke University Medical Center, Durham, NC.

Objectives: The list of tumors involving the pituitary gland has been expanded to include a variety of neuronal and paraneuronal tumors in the 2017 World Health Organization tumor classification of endocrine organs. All the entities included in this category are distinctly rare, with limited case reports in the literature.

Methods: We illustrate two extraordinary sellar tumors with neuronal differentiation: a sellar paraganglioma and a sellar neurocytoma, with thorough literature review and comparison of the clinicopathologic features of these entities. Read More

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December 2018

Antibiotic elution and mechanical property of TiO nanotubes functionalized PMMA-based bone cements.

J Mech Behav Biomed Mater 2018 Nov 23;91:91-98. Epub 2018 Nov 23.

Institute of Chemical and Engineering Sciences, A⁎STAR (Agency for Science, Technology and Research), 1 Pesek Road, Singapore 627833, Jurong Island, Singapore; Department of Chemical and Biomolecular Engineering, The National University of Singapore, 4 Engineering Drive 4, Singapore 117576, Singapore. Electronic address:

To overcome the disadvantage of current antibiotic bone cements with low drug elution efficiency, the hollow nanostructured titanium-dioxide (TiO) nanotubes (TNTs) were formulated with antibiotic loaded bone cement to create nano diffusion networks, enabling enhanced release of antibiotic. By incorporation of TNTs into Poly(methyl methacrylate) (PMMA) based bone cement, more than 50% of loaded antibiotic (such as gentamicin or vancomycin) could be released in two months. As comparison, only about 5% of total drug release was achieved in the absence of TNTs. Read More

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November 2018

A primer on patient-based quality control techniques.

Clin Biochem 2018 Dec 11. Epub 2018 Dec 11.

Sengkang General Hospital, Singapore; National University Hospital, Singapore.

Background: Patient-based Quality Control techniques have been described for more than fifty years and have been widely used routinely in hematology for forty. However, because of practical issues they have not been widely utilised in clinical chemistry laboratories. But recently because of the availability of middleware and a greater appreciation of the benefits of these processes there has been a willingness to investigate their use as a QC tool. Read More

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December 2018

Relationships between Financial Toxicity and Symptom Burden in Cancer Survivors: A Systematic Review.

J Pain Symptom Manage 2018 Dec 11. Epub 2018 Dec 11.

School of Nursing, Queensland University of Technology, Kelvin Grove, Q4059, Australia; Department of Physiological Nursing, University of California, San Francisco, 2 Koret Way - N631Y, San Francisco, CA 94143-0610.

Context: Financial toxicity (FT) is used to describe the financial distress/hardship associated with cancer and its treatment.

Objectives: The aim of this review was to explore the relationship between FT and symptom burden.

Method: A systematic review was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Read More

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December 2018
1 Read

Effect of Macrolide Prophylactic Therapy on AIDS-Defining Conditions and HIV-Associated Mortality.

J Acquir Immune Defic Syndr 2018 Dec 10. Epub 2018 Dec 10.

Research Institute for Tropical Medicine, Muntinlupa City, Philippines.

Background: Mycobacterium avium complex (MAC) prophylaxis is recommended for patients with advanced HIV infection. With the decrease in incidence of disseminated MAC infection and the availability of antiretroviral therapy (ART), the benefits of macrolide prophylaxis were investigated. This study examined the impact of macrolide prophylaxis on AIDS-defining conditions and HIV-associated mortality in a cohort of HIV-infected patients on ART. Read More

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December 2018

Anesthesia in Patients With Multiple-System Atrophy: A Narrative Review and Practice Guidance.

A A Pract 2018 Dec 13. Epub 2018 Dec 13.

Department of Anesthesiology and Pain Management, University of Texas Southwestern Medical Center, Dallas, Texas.

Multiple-system atrophy, a rare adult-onset neurodegenerative disease, is associated with autonomic dysfunction, features of parkinsonism, and cerebellar ataxia. This article discusses multiple-system atrophy pathophysiology, clinical presentation, and perioperative issues pertinent to anesthesia. Read More

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December 2018

A Flow Cytometry-Based Assay for High-Throughput Detection and Quantification of Neutrophil Extracellular Traps in Mixed Cell Populations.

Cytometry A 2018 Dec 14. Epub 2018 Dec 14.

Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

Neutrophil extracellular traps (NETs) are web-like structures composed of decondensed chromatin and antimicrobial proteins that are released into the extracellular space during microbial infections. This active cell death program is known as NETosis. To date, florescence microscopy is the widely accepted method for visualization and quantification of NETs. Read More

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December 2018

In Situ Electrochemical Conversion of Ultrathin Tannin-NiFe Complex Film as an Efficient Oxygen-Evolving Electrocatalyst.

Angew Chem Int Ed Engl 2018 Dec 14. Epub 2018 Dec 14.

Tianjin University, Department of Chemistry, #92, Weijin Road, Nankai District, Department of Chemistry, School of Science, Tianjin University, 300072, Tianjin, CHINA.

Oxygen evolution reaction (OER) is an important half reaction in many energy conversion and storage techniques. However, the development of a low-cost easy-prepared OER electrocatalyst with high mass activity and rapid kinetics is still challenging. Here, we report the facile deposition of tannin-NiFe (TANF) complex film on carbon fiber paper (CP) as a highly efficient OER electrocatalyst. Read More

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December 2018

Repetition Priming Effects for Famous Faces through Dynamic Causal Modelling of Latency-Corrected Event-Related Brain Potentials.

Eur J Neurosci 2018 Dec 14. Epub 2018 Dec 14.

Department of Physics, Hong Kong Baptist University, Kowloon Tong, Hong Kong.

Repetition priming, that is, the repeated processing of a stimulus, facilitates performance. However, the neural underpinnings of repetition priming for famous faces in terms of effective connectivity is not known. Here we investigated this problem using dynamic causal modelling of latency-corrected event-related brain potentials (RERPs). Read More

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December 2018
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RanGAP-mediated nucleocytoplasmic transport of Prospero regulates neural stem cell lifespan in Drosophila larval central brain.

Aging Cell 2018 Dec 13:e12854. Epub 2018 Dec 13.

Division of Human Reproduction and Developmental Genetics, The Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

By the end of neurogenesis in Drosophila pupal brain neuroblasts (NBs), nuclear Prospero (Pros) triggers cell cycle exit and terminates NB lifespan. Here, we reveal that in larval brain NBs, an intrinsic mechanism facilitates import and export of Pros across the nuclear envelope via a Ran-mediated nucleocytoplasmic transport system. In rangap mutants, the export of Pros from the nucleus to cytoplasm is impaired and the nucleocytoplasmic transport of Pros becomes one-way traffic, causing an early accumulation of Pros in the nuclei of the larval central brain NBs. Read More

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December 2018
6.340 Impact Factor

Defining a 'frequent admitter' phenotype among patients with repeat heart failure admissions.

Eur J Heart Fail 2018 Dec 13. Epub 2018 Dec 13.

National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore.

Aims: We aimed to identify a 'frequent admitter' phenotype among patients admitted for acute decompensated heart failure (HF).

Methods And Results: We studied 10 363 patients in a population-based prospective HF registry (2008-2012), segregated into clusters based on their 3-year HF readmission frequency trajectories. Using receiver-operating characteristic analysis, we identified the index year readmission frequency threshold that most accurately predicts HF admission frequency clusters. Read More

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December 2018

A Cross-linked Conjugated Polymer Photosensitizer Enables Efficient Sunlight-induced Photooxidation.

Angew Chem Int Ed Engl 2018 Dec 13. Epub 2018 Dec 13.

National University of Singapore, Department of Chemical and Biomolecular Engineering, 4 Engineering Drive 4, National University of Singapore, 117585, Singapore, SINGAPORE.

Photooxidation under sunlight has great potentials in organic synthesis, bacterial killing, organic waste treatment, etc. Photosensitizers (PSs) often play a very important role in this process. High 1O2 generation efficiency and excellent photostability under sunlight, as well as easy recyclability are ideal properties for PSs used for photooxidation, which are not easy to achieve simultaneously. Read More

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December 2018

Live single cell mass spectrometry reveals cancer-specific metabolic profiles of circulating tumor cells.

Cancer Sci 2018 Dec 14. Epub 2018 Dec 14.

Department of Biomarkers for Early Detection of Cancer, National Cancer Center Research Institute, Tokyo, Japan.

Recently, there has been an increased attention to circulating tumor cells (CTCs) analysis, also known as liquid biopsy, owing to its potential benefits in cancer diagnosis and treatment. CTCs are released from primary tumor lesions into the blood stream and eventually metastasize to distant body organs. However, a major hurdle with CTC analysis is their natural scarcity. Read More

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December 2018

Doping-Free White Organic Light-Emitting Diodes.

Chem Rec 2018 Dec 13. Epub 2018 Dec 13.

LUMINOUS!, Centre of Excellence for Semiconductor Lighting and Displays, School of Electrical and Electronic Engineering, Nanyang Technological University, Nanyang Avenue, 639798, Singapore.

Doping-free white organic light-emitting diodes (WOLEDs) have great potential to the next-generation solid-state lighting and displays due to the excellent properties, such as high efficiency, bright luminance, low power consumption, simplified structure and low cost. In this account, our recent developments on doping-free WOLEDs have been summarized. Firstly, fundamental concepts of doping-free WOLEDs have been described. Read More

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December 2018

Synthesis, Photophysical Properties and Two Photon Absorption Study of Tetraazachrysene-based N-heteroacenes.

Authors:
Qichun Zhang

Chem Asian J 2018 Dec 13. Epub 2018 Dec 13.

Nanyang Technological University, MSE, 50 Nanyang Ave, 639672, Singapore, SINGAPORE.

Three novel N-heteroacene molecules (SDNU-1, SDNU-2 and SDNU-3) based on tetraazachrysene units as cores have been designed, synthesized and fully characterized. Their photophysical, electrochemical and fluorescence properties were investigated, and they exhibited blue to green emission in solid state. Interestingly, SDNU-2 exhibited high solid photoluminescence quantum efficiencies (75. Read More

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December 2018
1 Read

Cognitive behavioural therapy can be effective in treating anxiety and depression in persons with dementia: a systematic review.

Psychogeriatrics 2018 Dec 13. Epub 2018 Dec 13.

School of Psychology, University of Queensland, Brisbane, St Lucia, Queensland, Australia.

Dementia is a neurocognitive disorder that affects a person's abilities in daily functioning. Anxiety and depression symptoms are common among persons with dementia. Cognitive behavioural therapy (CBT) has been tested to manage their depression and anxiety symptoms. Read More

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December 2018

The Australian Trauma Registry.

ANZ J Surg 2018 Dec 11. Epub 2018 Dec 11.

Metro North Hospital and Health Service, Brisbane, Queensland, Australia.

Introduction: Injuries are a major cause of disability and lost productivity. The case for a national trauma registry has been recognized by the Australian Commission on Safety and Quality in Health Care and at a policy level.

Background: The need was flagged in 1993 by the Royal Australasian College of Surgeons and the Australasian Trauma Society. Read More

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December 2018

The FZD7-TWIST1 axis is responsible for anoikis resistance and tumorigenesis in ovarian carcinoma.

Mol Oncol 2018 Dec 11. Epub 2018 Dec 11.

Cancer Science Institute of Singapore, Singapore, National University of Singapore, Center for Translational Medicine, 14 Medical DriveMD6 #12-01, Singapore, 117599.

Frizzled family receptor 7 (FZD7), a Wnt signaling receptor, is associated with the maintenance of stem cell properties and cancer progression. FZD7 has emerged as a potential therapeutic target because it is capable of transducing both canonical and non-canonical Wnt signals. In this study, we investigated the regulatory pathway downstream of FZD7 and its functional roles. Read More

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December 2018
5.331 Impact Factor

Scan and Learn: Quick Response Code Enabled Museum for Mobile Learning of Anatomy and Pathology.

Anat Sci Educ 2018 Dec 11. Epub 2018 Dec 11.

Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.

In the past, medical museums played a significant role in anatomy and pathology training. The attraction of medical museums has declined recently due to the emergence of information technology and innovative medical curricula. An innovative mobile learning platform has been developed using Quick Response (QR) codes for the museum specimens at the Lee Kong Chain School of Medicine, Singapore. Read More

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December 2018

Hierarchical Nanotubes Constructed by Co S /MoS Ultrathin Nanosheets Wrapped with Reduced Graphene Oxide for Advanced Lithium Storage.

Chem Asian J 2018 Dec 10. Epub 2018 Dec 10.

Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science and Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, 215123, P. R. China.

Nanostructured hybrid metal sulfides have attracted intensive attention due to their fascinating properties that are unattainable by the single-phased counterpart. Herein, we report an efficient approach to construct cobalt sulfide/molybdenum disulfide (Co S /MoS ) wrapped with reduced graphene oxide (rGO). The unique structures constructed by ultrathin nanosheets and synergetic effects benefitting from bimetallic sulfides provide improved lithium ions reaction kinetics, and they retain good structural integrity. Read More

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December 2018

Impact of diabetes and sex in heart failure with reduced ejection fraction patients from the ASIAN-HF registry.

Eur J Heart Fail 2018 Dec 10. Epub 2018 Dec 10.

National Heart Centre Singapore, Singapore.

Aims: To examine sex differences in clinical characteristics, echocardiographic features, quality of life and 1-year death or heart failure (HF) hospitalization outcomes in patients with/without diabetes mellitus (DM).

Methods And Results: Utilizing the Asian Sudden Cardiac Death in HF (ASIAN-HF) registry, 5255 patients (mean age 59.6 ± 13. Read More

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December 2018

Adoption of prophylactic cranial irradiation (PCI) for extensive stage small cell lung cancer (ES-SCLC): a population based outcome study.

Radiat Oncol 2018 Dec 14;13(1):247. Epub 2018 Dec 14.

Division of Radiation Oncology, National Cancer Center Singapore, Singapore, Singapore.

Background: The survival benefit of PCI in ES-SCLC reported by a European randomized trial (RCT) in 2007 was not replicated by a Japanese RCT published in 2017. This study aimed to evaluate the uptake of PCI before and after publication of the European RCT and its association with survival in ES-SCLC.

Methods: We identified eligible patients in the only two Singapore national cancer centres from 2003 to 2010. Read More

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December 2018

Reproduction of the Charge Density Wave Phase Diagram in 1T-TiSe_{2} Exposes its Excitonic Character.

Phys Rev Lett 2018 Nov;121(22):226602

Centre for Advanced 2D Materials and Graphene Research Centre, National University of Singapore, Singapore 117546.

Recent experiments suggest that excitonic degrees of freedom play an important role in precipitating the charge density wave (CDW) transition in 1T-TiSe_{2}. Through systematic calculations of the electronic and phonon spectrum based on density functional perturbation theory, we show that the predicted critical doping of the CDW phase overshoots the experimental value by 1 order of magnitude. In contrast, an independent self-consistent many-body calculation of the excitonic order parameter and renormalized band structure is able to capture the experimental phase diagram in extremely good qualitative and quantitative agreement. Read More

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November 2018

Computational Prediction of Drug-Target Interactions via Ensemble Learning.

Methods Mol Biol 2019 ;1903:239-254

Division of Software and Information Systems, School of Computer Science and Engineering, Nanyang Technological University, Singapore, Singapore.

Therapeutic effects of drugs are mediated via interactions between them and their intended targets. As such, prediction of drug-target interactions is of great importance. Drug-target interaction prediction is especially relevant in the case of drug repositioning where attempts are made to repurpose old drugs for new indications. Read More

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January 2019

Role of platelets in thrombin generation amongst patients with non-transfusion-dependent thalassaemia.

Ann Hematol 2018 Dec 13. Epub 2018 Dec 13.

Department of Haematology, Singapore General Hospital, Outram Road, Singapore, 169608, Singapore.

Non-transfusion-dependent thalassaemia (NTDT) is associated with a hypercoagulable state with thrombotic risk highest after splenectomy. Various mechanisms have been proposed. Although an antiplatelet agent is commonly recommended as thromboprophylaxis in NTDT, the role of platelets contributing to this hypercoagulable state is not well-defined. Read More

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December 2018
2.634 Impact Factor

Durian Fruits Discovered as Superior Folate Sources.

Front Nutr 2018 28;5:114. Epub 2018 Nov 28.

Chair of Analytical Food Chemistry, Technical University of Munich, Freising, Germany.

Durian () is a tropical fruit grown in Southeast Asia and highly appreciated by consumers throughout Asia. Folates are a group of vitamins and are essential nutrients for humans. Here we present the folate analysis of different durian cultivars as well as diverse durian products. Read More

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November 2018

Orthodontic-surgical management of an unusual dilacerated maxillary incisor.

J Orthod Sci 2018 15;7:24. Epub 2018 Nov 15.

Department of Orthodontics, National Dental Centre Singapore, 5 Second Hospital Avenue, Singapore 168938.

Orthodontic traction of an impacted dilacerated maxillary central incisor is clinically challenging and often results in a long treatment duration. A case of an unusual dilacerated central incisor with a 90° crown-root angulation and palatally displaced crown is presented herein. Using a single stage open window exposure of the crown on the palatal aspect with light orthodontic traction force, the impacted dilacerated central incisor crown was successfully positioned in alignment with the contralateral incisor. Read More

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November 2018

B cells in esophago-gastric adenocarcinoma are highly differentiated, organize in tertiary lymphoid structures and produce tumor-specific antibodies.

Oncoimmunology 2019 2;8(1):e1512458. Epub 2018 Nov 2.

German Cancer Consortium (DKTK), Heidelberg, Germany.

Tumor-infiltrating lymphocytes (TILs) are correlated to prognosis of several kinds of cancer. Most studies focused on T cells, while the role of tumor-associated B cells (TABs) has only recently gained more attention. TABs contain subpopulations with distinct functions, potentially promoting or inhibiting immune responses. Read More

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November 2018

Association between childhood invalidation and borderline personality symptoms: self-construal and conformity as moderating factors.

Borderline Personal Disord Emot Dysregul 2018 7;5:19. Epub 2018 Dec 7.

2Department of Psychological Medicine, National University of Singapore, Singapore, Singapore.

Background: Linehan (1993)'s biosocial model posits that borderline personality disorder (BPD) symptoms develop as a result of a transactional relationship between pre-existing emotional vulnerability and an invalidating childhood environment. Little work, however, has investigated cultural factors that may influence the relationship between childhood invalidation and BPD symptoms. The present study investigated the association between parental invalidation and BPD symptoms, and the role of conformity and self-construal as potential moderators of this association. Read More

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December 2018
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Correction: Serine 207 phosphorylated lysyl-tRNA synthetase predicts disease-free survival of non-small-cell lung carcinoma.

Oncotarget 2018 Nov 16;9(90):36250. Epub 2018 Nov 16.

Department of Biochemistry and Molecular Biology, Institute for Medical Research Israel-Canada, The Hebrew University of Jerusalem, Jerusalem, Israel.

[This corrects the article DOI: 10.18632/oncotarget.18053. Read More

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November 2018

A combined microfluidic-transcriptomic approach to characterize the extravasation potential of cancer cells.

Oncotarget 2018 Nov 16;9(90):36110-36125. Epub 2018 Nov 16.

BioSystems and Micromechanics IRG, Singapore-MIT Alliance for Research and Technology, Singapore.

The reciprocal interaction between circulating tumor cells (CTCs) and tissue-specific cells is influential for the progression of metastases. In particular, the process of extravasation relies on the complex cross-talk between cancer cells and other cellular players such as the endothelium and the secondary tissue. However, most studies only focus on one heterotypic cell-cell interaction and often lack of physiological relevance. Read More

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November 2018

p53-Sensitive Epileptic Behavior and Inflammation in Hypomorphic Mice.

Front Genet 2018 27;9:581. Epub 2018 Nov 27.

Department of Biology and Biotechnology, Sapienza University of Rome, Rome, Italy.

Epilepsy is a complex clinical condition characterized by repeated spontaneous seizures. Seizures have been linked to multiple drivers including DNA damage accumulation. Investigation of epilepsy physiopathology in humans imposes ethical and practical limitations, for this reason model systems are mostly preferred. Read More

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November 2018

Topiramate and Metformin Are Effective Add-On Treatments in Controlling Antipsychotic-Induced Weight Gain: A Systematic Review and Network Meta-Analysis.

Front Pharmacol 2018 28;9:1393. Epub 2018 Nov 28.

Institute for Mental Health, University of Birmingham, Birmingham, United Kingdom.

Antipsychotic drugs may lead to side effects such as obesity, diabetes, dyslipidemia, and cardiovascular disease. The current systematic review and network meta-analysis analyzes and provides an update on the clinical performance of these add-ons in comparison to placebo on body weight and body mass index (BMI) reductions. A comprehensive literature search was performed on electronic databases: PubMed (1946-), Embase (1974-), Cochrane library (1992-), and OpenGrey (2000-) until 31 July 2018. Read More

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November 2018
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Genomic and transcriptomic landscapes of Epstein-Barr virus in extranodal natural killer T-cell lymphoma.

Leukemia 2018 Dec 13. Epub 2018 Dec 13.

Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.

Extranodal natural killer T-cell lymphoma (nasal type; NKTCL) is an aggressive malignancy strongly associated with Epstein-Barr virus (EBV) infection. However, the role of EBV in NKTCL development is unclear, largely due to the lack of information about EBV genome and transcriptome in NKTCL. Here, using high-throughput sequencing, we obtained whole genome (n = 27) and transcriptome datasets (n = 18) of EBV derived from NKTCL tumor biopsies. Read More

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December 2018