9,153 results match your criteria Silicosis


Correspondence on 'Demographic, exposure and clinical characteristics in a multinational registry of engineered stone workers with silicosis' by Hua .

Occup Environ Med 2022 Jun 23. Epub 2022 Jun 23.

Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.

View Article and Full-Text PDF

Minute Cellular Nodules as Early Lesions in Rats with Silica Exposure via Inhalation.

Vet Sci 2022 May 25;9(6). Epub 2022 May 25.

Hebei Key Laboratory for Organ Fibrosis Research, School of Public Health, North China University of Science and Technology, Tangshan 063210, China.

Mechanisms of silicosis have yet to be clarified, and pathological conditions are inaccurately described in some experimental studies on silicosis. This study was aimed at describing initial lesions in silicosis, as observed in rats with silica exposure via inhalation, and major histopathologic alterations. Male Wistar rats were exposed to silica for 24 weeks. Read More

View Article and Full-Text PDF

Deadly dust: Silicotuberculosis as a downplayed and overlooked fatal disease in Indonesia.

Ann Med Surg (Lond) 2022 Jun 17;78:103794. Epub 2022 May 17.

Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Airlangga - Dr. Soetomo General Academic Hospital, Surabaya, Indonesia.

Background: Silicosis is one of the most common diseases among all occupational diseases. The main clinical focus on the silicosis complication will be tuberculosis.

Case Presentation: A 28-year-old male presented with complaints of chronic dry cough, weight loss, decreased appetite, and night sweats. Read More

View Article and Full-Text PDF

Soil Microbial Communities Affect the Growth and Secondary Metabolite Accumulation in (Thunb.) Rchb. f.

Front Microbiol 2022 6;13:916418. Epub 2022 Jun 6.

Resource Institute for Chinese and Ethnic Materia Medica, Guizhou University of Traditional Chinese Medicine, Guiyang, China.

(Thunb.) Rchb.f. Read More

View Article and Full-Text PDF

Progressive massive fibrosis: An overview of the recent literature.

Authors:
David N Weissman

Pharmacol Ther 2022 Jun 19;240:108232. Epub 2022 Jun 19.

National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV, United States of America. Electronic address:

This review provides an overview of literature addressing progressive massive fibrosis (PMF) from September 2009 to the present. Advances are described in understanding its pathophysiology, epidemiology of the occurrence of PMF and related conditions, the impact of PMF on pulmonary function, advances in imaging of PMF, and factors affecting progression of pneumoconiosis in dust-exposed workers to PMF. Basic advances in understanding the etiology of PMF are impeded by the lack of a well-accepted animal model for human PMF. Read More

View Article and Full-Text PDF

Global and national burden and trends of mortality and disability-adjusted life years for silicosis, from 1990 to 2019: results from the Global Burden of Disease study 2019.

BMC Pulm Med 2022 Jun 21;22(1):240. Epub 2022 Jun 21.

College of Pulmonary and Critical Care Medicine, Chinese PLA General Hospital, Beijing, China.

Background: Silicosis, as an important type of pneumoconiosis, leads to progressive and irreversible conditions from the beginning of inflammation and fibrosis. However, the data on the global burden of silicosis and long-term trends were limited.

Methods: Derived from the Global Burden of Disease study 2019 (online publicly available: Global Health Data Exchange), data on both crude and age-standardized rates (ASR) per 100,00 people of mortality and disability-adjusted life years (DALYs) due to silicosis was collected and analyzed. Read More

View Article and Full-Text PDF

The regulatory effect of pulmonary lymphatic drainage on silicosis fibrosis.

Ecotoxicol Environ Saf 2022 Jun 15;241:113758. Epub 2022 Jun 15.

School of Public Health, North China University of Science and Technology, Tangshan, Hebei 063210, China. Electronic address:

Silicosis is a fibrotic disease caused by long-term inhalation of SiO particles that currently has no effective treatment. Earlier studies have suggested that pulmonary lymphatic vessels play a key role in the transport of silica but have not address the long-term effects of altered pulmonary lymphatic drainage on silicosis. Here, we investigated the impact of impaired pulmonary lymphatic drainage on silicosis. Read More

View Article and Full-Text PDF

Monitoring Worker Exposure to Respirable Crystalline Silica: Application for Data-driven Predictive Modeling for End-of-Shift Exposure Assessment.

Ann Work Expo Health 2022 Jun 18. Epub 2022 Jun 18.

Centers for Disease Control and Prevention (CDC), National Institute for Occupational Safety and Health (NIOSH), Pittsburgh Mining Research Division (PMRD), 626 Cochran Mill Rd Pittsburgh, PA, 15236  USA.

In the ever-expanding complexities of the modern-day mining workplace, the continual monitoring of a safe and healthy work environment is a growing challenge. One specific workplace exposure concern is the inhalation of dust containing respirable crystalline silica (RCS) which can lead to silicosis, a potentially fatal lung disease. This is a recognized and regulated health hazard, commonly found in mining. Read More

View Article and Full-Text PDF

Prevalence and clinical impact of systemic autoimmune rheumatic disease in patients with silicosis.

Arch Bronconeumol 2021 Sep 17;57(9):571-576. Epub 2021 Jul 17.

Servicio de Neumoloxía, Complexo Hospitalario Universitario de Santiago de Compostela, Spanish Biomedical Research Networking Centre-CIBERES, A Coruña, Spain.

Background: Silicosis is associated with an increased risk of developing systemic autoimmune rheumatic disease (SARD). The prognostic implications of this association are poorly characterized. The aim of this study was to determine the prevalence of SARD and autoimmune markers in a cohort of patients with exposure to silica and assess their impact on prognosis. Read More

View Article and Full-Text PDF
September 2021

[Investigation on diagnosis of pneumoconiosis in non-coal mining industry in Jiangsu Province].

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2022 May;40(5):358-361

Occupational Disease Prevention and Control Institute, Jiangsu Center for Disease Control and Prevention, Nanjing 210028, China.

To understand the incidence of pneumoconiosis in the non-coal mining industry in Jiangsu Province, and provide reference for the prevention and control of pneumoconiosis in the non-coal mining industry. The data of 7019 newly diagnosed pneumoconiosis patients in non-coal mining industry in Jiangsu Province from January 1956 to December 2019 were collected through the Jiangsu Province Pneumoconiosis Follow-up Network Report System, including the gender of the pneumoconiosis patients, the name of the employer and the location, the industry classification of the employer, the duration of dust exposure in dust exposure, the name of occupational pneumoconiosis disease, the date of diagnosis of pneumoconiosis, etc. The collected case data of patients with pneumoconiosis were entered into the statistical software, and the characteristics of the patients' diagnosis time, region and industry were analyzed. Read More

View Article and Full-Text PDF

[Analysis of incidence characteristics and trend of pneumoconiosis in Ningbo City from 1967 to 2019].

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2022 May;40(5):354-358

Environmental and Occupational Health Institute, Ningbo Municipal Center for Disease Control and Prevention, Ningbo 315010, China.

To understand the incidence of pneumoconiosis in Ningbo city from 1967 to 2019, and to analyze the distribution characteristics and change trend of pneumoconiosis. In February 2021, the data of pneumoconiosis patients in Ningbo city from 1967 to 2019 were sorted out. The data from 1967 to 1987 were from historical case files of Zhejiang Center for Disease Control and Prevention, the data from 1988 to 2005 were from the historical case files of Ningbo Center for Disease Control and Prevention, and the data from 2006 to 2019 were from the pneumoconiosis report card in China Disease Prevention and Control Information System; Followed up and supplement relevant information, including basic information, basic information of employers and information related to pneumoconiosis diagnosis, and comprehensively analyze the composition and development trend, population characteristics and industry characteristics of pneumoconiosis. Read More

View Article and Full-Text PDF

[Survival and disease burden trend analysis of occupational pneumoconiosis from 1963 to 2020 in Shizuishan City].

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2022 May;40(5):341-347

Shizuishan City Center for Disease Control and Prevention, Shizuishan 753000, China.

To understand the survival status and its influencing factors of occupational pneumoconiosis patients in Shizuishan City, and to analyze the disease burden of occupational pneumoconiosis and its trend, so as to provide scientific basis for formulating comprehensive prevention and treatment measures of occupational pneumoconiosis. A retrospective survey was conducted during July to December 2020 to explore the survival status of occupational pneumoconiosis patients who had been reported from 1963 to 2020 in Shizuishan City. The Kaplan-Meier method and Life-table method were used for survival analysis, and Cox proportional hazards regression model was used to analyze the influencing factors of survival time. Read More

View Article and Full-Text PDF

[The influencing factors of cognitive impairment in patients with silicosis].

Authors:
H G Huang Y Q Jiang

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2022 May;40(5):333-336

Department of Respiratory Medicine, the First People's Hospital of Wenling, Wenling317500, China.

To explore the influencing factors of cognitive impairment in patients with silicosis, and to analyze the effect of brain-derived neurotrophic factor (BDNF) on cognitive function. In March 2021, 484 silicosis patients from April 2018 to April 2020 were included in the study. The Montreal Cognitive Assessment Scale of Chinese version was used to evaluate their cognitive function, and they were divided into the cognitive impairment group (=282) and the non cognitive impairment group (=202) , another 30 healthy persons from body check were served as control group. Read More

View Article and Full-Text PDF

Epidemiology of silicosis reported to the central register of occupational diseases over last 20 years in Poland.

Int J Occup Med Environ Health 2022 Jun 9. Epub 2022 Jun 9.

Nofer Institute of Occupational Medicine, Łódź, Poland (Department of Environmental Epidemiology).

Objectives: The aim of the study was to investigate and assess the incidence of silicosis cases acknowledged as occupational diseases in Poland in 2000-2019.

Material And Methods: The cases of all medically recognized pneumoconioses, including silicoses, certified as occupational diseases were studied. The records were extracted from the Central Register of Occupational Diseases, the only official Polish central electronic data base of occupational diseases. Read More

View Article and Full-Text PDF

Asian dust storms result in a higher risk of the silicosis hospital admissions.

J Environ Health Sci Eng 2022 Jun 21;20(1):305-314. Epub 2022 Jan 21.

Department of Public Finance, National Taipei University, 151, University Rd., San Shia, New Taipei City, Taiwan 237.

Purpose: Previous studies found that silicosis was majorly associated with occupation-related risks. However, little evidence was available to clarify the relation between Asian dust storm (ADS) and silicosis hospital admissions. This present paper aims to investigate the association between ADS events and hospital admissions for silicosis. Read More

View Article and Full-Text PDF

Three's Company: Coexistence of Silicosis, Scleroderma, and Sjogren Syndrome in a Single Patient.

Case Rep Rheumatol 2022 27;2022:4487638. Epub 2022 May 27.

Department of Medicine "B", Sheba Medical Center, Tel-Hashomer, Ramat Gan, Israel.

We describe a patient who presented with silicosis, scleroderma, and Sjogren syndrome all at the same time. The diagnoses in this case are all associated with continuous exposure to crystalline silica at the patient's workplace. The following report discusses this unique presentation. Read More

View Article and Full-Text PDF

Diagnostic challenges of radiological opacities in silicosis - case reports.

Occup Med (Lond) 2022 Jun 5. Epub 2022 Jun 5.

Clinical Department 4, "Carol Davila" University of Medicine and Pharmacy, 050474  Bucharest, Romania.

Occupational exposure to crystalline silica dust in the workplace can cause lung damage (silicosis, chronic airflow limitation and lung cancer). Silicosis results from the fibrotic reaction to the deposition of inhaled crystalline silica dust in the lung tissue. Even though many coalmines and foundries have closed, crystalline silica is still widely used, making silicosis a significant public health issue. Read More

View Article and Full-Text PDF

The burden of pneumoconiosis in China: an analysis from the Global Burden of Disease Study 2019.

BMC Public Health 2022 Jun 3;22(1):1114. Epub 2022 Jun 3.

National Center for Chronic and Noncommunicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, 27 Nanwei Road, Xicheng District, Beijing, 100050, China.

Background: Pneumoconiosis refers to a class of serious diseases threatening the health of workers exposed to coal or silicosis dust. However, the burden of pneumoconiosis is unavailable in China.

Methods: Incident cases, deaths, and disability-adjusted life years (DALYs) from pneumoconiosis and its subtypes in China were estimated from the Global Burden of Disease Study 2019 using a Bayesian meta-regression method. Read More

View Article and Full-Text PDF

Pulmonary hypertension in patients with pneumoconiosis with progressive massive fibrosis.

Occup Environ Med 2022 Jun 2. Epub 2022 Jun 2.

Department of Occupational Medicine and Toxicology, Clinical Center for Interstitial Lung Diseases, Beijing Institute of Respiratory Medicine, Beijing Chao-Yang Hospital Capital Medical University, Beijing, China

Objectives: This study aims to explore the prevalence and clinical features of pulmonary hypertension (PH) in patients with progressive massive fibrosis (PMF) and its correlation with large opacities on CT scans.

Methods: This retrospective study collected 235 patients with PMF, and 199 were eligible for analysis. The probability of PH development was estimated based on tricuspid regurgitation velocity measured by echocardiogram. Read More

View Article and Full-Text PDF

Dihydroquercetin Attenuates Silica-Induced Pulmonary Fibrosis by Inhibiting Ferroptosis Signaling Pathway.

Front Pharmacol 2022 12;13:845600. Epub 2022 May 12.

Department of Clinical Laboratory, Southern University of Science and Technology Hospital, Shenzhen, China.

Silicosis is a fatal occupational lung disease which currently has no effective treatment. Dihydroquercetin (DHQ) is a flavonoid compound known for its anti-inflammatory, anti-oxidant and anti-cancer bioactivity. However, whether DHQ protects against silica-induced lung fibrosis remains unknown. Read More

View Article and Full-Text PDF

Non-malignant silica-related diseases in a specialized outpatient clinic.

Occup Med (Lond) 2022 May 27. Epub 2022 May 27.

Division of Applied Research; FUNDACENTRO, São Paulo, Brazil.

Background: Uncontrolled occupational exposure to silica is still frequent in Brazil, with several recent records in the state of Minas Gerais. However, few national studies have addressed silica-related diseases other than silicosis.

Aims: To describe the occurrence of the main non-malignant silica-related diseases: silicosis, tuberculosis (TB), chronic obstructive pulmonary disease (COPD), and autoimmune diseases in a specialized outpatient clinic. Read More

View Article and Full-Text PDF

Oridonin suppresses particulate-induced NLRP3-independent IL-1α release to prevent crystallopathy in the lung.

Int Immunol 2022 May 27. Epub 2022 May 27.

Laboratory of Bioresponse Regulation, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, 565-0871, Japan.

The human body is exposed to various particulates of industrial, environmental, or endogenous origin. Invading or intrinsic particulates can induce inflammation by aberrantly activating the immune system, thereby causing crystallopathies. When immune cells such as macrophages phagocytose the particulates, their phagolysosomal membranes undergo mechanical damage, eventually leading to pyroptotic cell death accompanied by the release of inflammatory cytokines, including interleukin (IL)-1αand IL-1β. Read More

View Article and Full-Text PDF

Thalidomide Alleviates Pulmonary Fibrosis Induced by Silica in Mice by Inhibiting ER Stress and the TLR4-NF-κB Pathway.

Int J Mol Sci 2022 May 18;23(10). Epub 2022 May 18.

Hebei Key Laboratory for Organ Fibrosis Research, School of Public Health, North China University of Science and Technology, Tangshan 063210, China.

Silicosis is the most prevalent occupational disease in China. It is a form of pulmonary fibrosis caused by the inhalation of silicon particles. As there is no cure for the potentially lethal and progressive condition, the treatment of silicotic fibrosis is an important and difficult problem to address. Read More

View Article and Full-Text PDF

Tauroursodeoxycholic acid (TUDCA) disparate pharmacological effects to lung tissue-resident memory T cells contribute to alleviated silicosis.

Biomed Pharmacother 2022 Jul 24;151:113173. Epub 2022 May 24.

Division of Pneumoconiosis, School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang 110122, China. Electronic address:

Exposure to crystalline silica (CS) results in a persistent pulmonary inflammatory response, which results in abnormal tissue repair and excessive matrix deposition. Due to vague pathogenesis, there is virtually no practical therapeutic approach. Here we showed the pharmacological effects of TUDCA on CS-induced pulmonary inflammation and fibrosis. Read More

View Article and Full-Text PDF

Silicosis-related pleural effusion diagnosed using elemental analysis of the pleural fluid cell block: A case report.

Respir Med Case Rep 2022 11;37:101665. Epub 2022 May 11.

Division of Respiratory Medicine, Juntendo University Faculty of Medicine and Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.

Pleural disease in silicosis remains an underrecognized entity. Herein, we describe the case of an 85-year-old man with a 20-year history of silica exposure between the ages of 9-28 years. He presented with bilateral exudative pleural effusions, and chest computed tomography revealed typical silicosis findings. Read More

View Article and Full-Text PDF

Inflammatory indices obtained from routine blood tests show an inflammatory state associated with disease progression in engineered stone silicosis patients.

Sci Rep 2022 May 17;12(1):8211. Epub 2022 May 17.

Biomedical Research and Innovation Institute of Cadiz (INiBICA), 11009, Cádiz, Spain.

Patients with silicosis caused by occupational exposure to engineered stone (ES) present a rapid progression from simple silicosis (SS) to progressive massive fibrosis (PMF). Patient classification follows international rules based on radiology and high-resolution computed tomography (HRCT), but limited studies, if any, have explored biomarkers from routine clinical tests that can be used as predictors of disease status. Our objective was thus to investigate circulating biomarker levels and systemic inflammatory indices in ES silicosis patients whose exposure to ES dust ended several years ago. Read More

View Article and Full-Text PDF

Gefitinib and fostamatinib target EGFR and SYK to attenuate silicosis: a multi-omics study with drug exploration.

Signal Transduct Target Ther 2022 05 13;7(1):157. Epub 2022 May 13.

State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, 100005, China.

Silicosis is the most prevalent and fatal occupational disease with no effective therapeutics, and currently used drugs cannot reverse the disease progress. Worse still, there are still challenges to be addressed to fully decipher the intricated pathogenesis. Thus, specifying the essential mechanisms and targets in silicosis progression then exploring anti-silicosis pharmacuticals are desperately needed. Read More

View Article and Full-Text PDF

Erasmus Syndrome: An Underrecognized Entity.

Acta Med Port 2022 May 13. Epub 2022 May 13.

Pulmonology Department. Hospital de Santa Marta. Centro Hospitalar Universitário Lisboa Central. Lisboa. Portugal.

We present a case of a 33-year-old male who worked as a plumber and a locksmith. The patient presented with diffuse myalgia and asthenia, skin sclerosis and puffy fingers, Raynaud's phenomenon, exertional dyspnea and erectile dysfunction. The presence of specific autoantibodies enabled the diagnosis of systemic sclerosis. Read More

View Article and Full-Text PDF

[Analysis on incidence of occupational diseases in Guangzhou from 2010 to 2020].

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2022 Apr;40(4):292-295

Guangzhou Occupational Disease Prevention and Treatment Hospital, Guangzhou 510620, China.

To analyze the incidence characteristics of occupational diseases in Guangzhou from 2010 to 2020, provide scientific basis for formulating occupational disease prevention and control policies. In January 2021, based on the data of occupational diseases in Guangzhou reported in the Information Monitoring System of Occupational Diseases and Occupational Health, descriptive epidemiological method was used to analyze the types and characteristics of occupational diseases in Guangzhou from 2010 to 2020. A total of 1341 cases of 38 kinds of occupational diseases in 9 categories were reported in the past 11 years. Read More

View Article and Full-Text PDF

Inhibition of gasdermin D-dependent pyroptosis attenuates the progression of silica-induced pulmonary inflammation and fibrosis.

Acta Pharm Sin B 2022 Mar 15;12(3):1213-1224. Epub 2021 Oct 15.

State Key Laboratory of Medical Molecular Biology, Department of Physiology, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing 100730, China.

Silicosis is a leading cause of occupational disease-related morbidity and mortality worldwide, but the molecular basis underlying its development remains unclear. An accumulating body of evidence supports gasdermin D (GSDMD)-mediated pyroptosis as a key component in the development of various pulmonary diseases. However, there is little experimental evidence connecting silicosis and GSDMD-driven pyroptosis. Read More

View Article and Full-Text PDF