8,949 results match your criteria Silicosis

Silicon, an important exposure marker in vivo in silicosis research.

Int Arch Occup Environ Health 2021 Jun 10. Epub 2021 Jun 10.

School of Public Health, North China University of Science and Technology, Tangshan, 063210, China.

Purpose: The degree of silicosis exposure is closely related to the progress of silicosis. At present, we use animal and human studies to explore whether silicon can be an important exposure marker in the development of silicosis.

Methods: Rats were randomly divided into 2 groups: (1) controls; and (2) silicosis. Read More

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Triiodothyronine ameliorates silica-induced pulmonary inflammation and fibrosis in mice.

Sci Total Environ 2021 May 26;790:148041. Epub 2021 May 26.

Department of Occupational & Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. Electronic address:

Environmental exposure to silica or particles is very common in natural, agricultural and industrial activities. Chronic silica exposure can lead to silicosis, which remains one of the most serious interstitial lung diseases all through the world, while viable therapeutic choices are restricted. Triiodothyronine (T3) has been shown to exert a defensive role in many pulmonary diseases, however, rare data are available regarding the role of T3 on silica-induced injury. Read More

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miR-770-5p inhibits the activation of pulmonary fibroblasts and silica-induced pulmonary fibrosis through targeting TGFBR1.

Ecotoxicol Environ Saf 2021 May 31;220:112372. Epub 2021 May 31.

Department of Occupational Medicine and Environmental Health, Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing 210029, China. Electronic address:

Silicosis is a devastating interstitial lung disease arising from long-term exposure to inhalable silica. Regrettably, no therapy currently can effectively reverse the silica-induced fibrotic lesion. Emerging evidence has indicated that the dysregulation of microRNAs is involved in silica-induced pulmonary fibrosis. Read More

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Mesenchymal stem cells ameliorate silica-induced pulmonary fibrosis by inhibition of inflammation and epithelial-mesenchymal transition.

J Cell Mol Med 2021 Jun 2. Epub 2021 Jun 2.

School of Public Health, Zhengzhou University, Zhengzhou, China.

Silicosis is a devastating occupational disease caused by long-term inhalation of silica particles, inducing irreversible lung damage and affecting lung function, without effective treatment. Mesenchymal stem cells (MSCs) are a heterogeneous subset of adult stem cells that exhibit excellent self-renewal capacity, multi-lineage differentiation potential and immunomodulatory properties. The aim of this study was to explore the effect of bone marrow-derived mesenchymal stem cells (BMSCs) in a silica-induced rat model of pulmonary fibrosis. Read More

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Association between Crystalline Silica Dust Exposure and Silicosis Development in Artificial Stone Workers.

Int J Environ Res Public Health 2021 May 25;18(11). Epub 2021 May 25.

Department of Legal Medicine and Toxicology, University of Granada School of Medicine, 18016 Granada, Spain.

Occupational exposure to respirable crystalline silica (SiO) is one of the most common and serious risks because of the health consequences for the workers involved. Silicosis is a progressive, irreversible, and incurable fibrotic lung disease caused by the inhalation of respirable crystalline silica dust. A cross-sectional epidemiological study was carried out to assess the occupational risk factors that may contribute to the onset of silicosis in workers carrying out work activities with the inhalation of silica compact dust. Read More

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A study of oxidative stress and pulmonary damage after silica instillation in rats and the effect of curcumin administration.

Med Pr 2021 May 10. Epub 2021 May 10.

Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania (Department of Medical Informatics and Biostatistics).

Background: The authors' aim was to study the dynamics of oxidative stress in experimental exposure to silica dust, to evaluate the histopathological findings in the phase preceding the formation of fibrous/fibrohyaline pulmonary nodules, and to assess the effects of curcumin administration.

Material And Methods: The research was performed on 48 male Wistar rats with an average weight of 320 g. Overall, 38 rats were instilled with a single dose of 0. Read More

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Transcriptional Signatures of Human Peripheral Blood Mononuclear Cells Can Identify the Risk of Tuberculosis Progression from Latent Infection among Individuals with Silicosis.

Emerg Microbes Infect 2021 May 27:1-24. Epub 2021 May 27.

Department of Infectious Diseases, Huashan Hospital, School of Life Science, Fudan University, Shanghai 200040, China.

Trial Registration Information: www.clinicaltrials.gov (NCT02430259) ClinicalTrials. Read More

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Silicosis, progressive massive fibrosis and silico-tuberculosis among workers with occupational exposure to silica dusts in sandstone mines of Rajasthan state: An urgent need for initiating national silicosis control programme in India.

J Family Med Prim Care 2021 Feb 27;10(2):686-691. Epub 2021 Feb 27.

Director, National Institute of Occupational Health, Ahmedabad, Gujarat, India.

Context: Silicosis is a progressive, irreversible and incurable respiratory morbidity and often becomes a cause for pre-mature mortality among occupationally silica dust-exposed workers in India and similar countries. It has a dual problem of associated silico-tuberculosis as a co-morbidity. The present study was done to assess the respiratory morbidity caused by silicosis in sandstone mine of Rajasthan, India. Read More

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February 2021

[Silica causes difficulties].

Rev Mal Respir 2021 May 19. Epub 2021 May 19.

Pneumologie et oncologie thoracique, CHU de Saint Etienne, Saint Etienne, France; Pneumologie et oncologie thoracique, CHU Saint-Étienne, Saint-Étienne, France.

Silicosis and sarcoidosis are two very distinct entities in the literature. All the additional non-invasive examinations, including the chest CT scan, often do not differentiate them. The history, including occupational exposure to identified silica particles, is a discriminating factor. Read More

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Downregulation of the PD-1/PD-Ls pathway in peripheral cells correlates with asbestosis severity.

BMC Pulm Med 2021 May 22;21(1):175. Epub 2021 May 22.

Department of Occupational Medicine and Toxicology, Beijing Institute of Respiratory Medicine, Beijing Chao-Yang Hospital, Capital Medical University, No. 8 Worker's Stadium, Chao-Yang District, Beijing, China.

Background: Asbestosis and silicosis are characterized by diffuse or nodular interstitial lung fibrosis resulting from exposure to asbestos or silica dust, respectively. This study was designed to detect programmed cell death protein (PD-1)/programmed death ligands (PD-Ls) expression in patients with asbestosis and silicosis and to explore the possible clinical significance of PD-1/PD-Ls expression in patients with the two diseases.

Methods: Thirty patients with asbestosis, 23 patients with silicosis and 25 healthy controls were consecutively recruited and provided informed consent to participate in the study. Read More

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The B Reader Program, Silicosis, and Physician Workload Management: A Niche for AI Technologies.

J Occup Environ Med 2021 May 19. Epub 2021 May 19.

Harvard Law School, Cambridge, Massachusetts Harvard T. H. Chan School of Public Health, Boston, Massachusetts MedLaw LLC, Chief Medical and Science Officer Dartmouth College Geisel School of Medicine, Clinical Assistant Professor University of New England, Clinical Assistant Professor.

The National Institute for Occupational Safety and Health (NIOSH) has operated its B Reader Program for over fifty years. Originally intended as a screening program for black lung disease, it has since received a broadened mandate to cover other occupational pneumoconioses, such as silicosis. At the same time, the B Reader Program itself has witnessed a consistently declining pool of participating physicians, alongside high levels of subjectivity and possible financial conflicts of interest. Read More

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The association between silica exposure, silicosis and tuberculosis: a systematic review and meta-analysis.

BMC Public Health 2021 05 20;21(1):953. Epub 2021 May 20.

National Institute for Occupational Health, Johannesburg, South Africa.

Background: While the association between occupational inhalation of silica dust and pulmonary tuberculosis has been known for over a century, there has never been a published systematic review, particularly of experience in the current era of less severe silicosis and treatable tuberculosis. We undertook a systematic review of the evidence for the association between (1) silicosis and pulmonary tuberculosis, and (2) silica exposure and pulmonary tuberculosis controlling for silicosis, and their respective exposure-response gradients.

Methods: We searched PUBMED and EMBASE, and selected studies according to a priori inclusion criteria. Read More

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Genetic damage in coal and uranium miners.

Mutat Res 2021 Jun 16;866:503348. Epub 2021 Mar 16.

Programa de Pós-graduação em Ciências da Saúde, Faculdade de Medicina, Universidade Federal do Rio Grande, FURG, Rio Grande, Brazil; Laboratório de Ensaios Farmacológicos e Toxicológicos, Instituto de Ciências Biológicas, Universidade Federal do Rio Grande, FURG, Brazil.

Mining has a direct impact on the environment and on the health of miners and is considered one of the most hazardous occupations worldwide. Miners are exposed to several occupational health risks, including genotoxic substances, which may cause adverse health effects, such as cancer. This review summarizes the relation between DNA damage and mining activities, focusing on coal and uranium miners. Read More

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[Role of PTEN in FAK and α-SMA protein levels changes in human embryonic lung fibroblasts induced by silica].

Wei Sheng Yan Jiu 2021 Mar;50(2):223-229

National Institute of Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing 100050, China.

Objective: To investigate the roles of phosphatase and tensin homolog deleted on chromosome 10(PTEN) in focal adhesion kinase(FAK) and α-smooth muscle actin(α-SMA) protein levels changes in human embryonic lung fibroblasts(HELFs) induced by silica.

Methods: The HELF cells were cultured in low serum medium containing 0, 25, 50, 100 and 200 μg/cm~2 silica for 24 hours, and the cell counting kit-8(CCK8) experiment was used to determine the appropriate dose of silica for stimulation. Meanwhile, the effect of different doses of silica on the morphology of HELFs was observed under inverted microscope. Read More

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Artificial stone-associated silicosis with concurrent Cryptococcus infection.

Respirol Case Rep 2021 Jun 6;9(6):e00765. Epub 2021 May 6.

Institute of Emergency and Critical Care Medicine National Yang Ming Chiao Tung University Taipei Taiwan.

Acute silicoproteinosis is a disease that develops in weeks, and lasting for years, after massive exposure to silica dust in relatively closed spaces. It was rare, but the cases have recently increased worldwide due to the development of artificial stone industry. Compared with traditional silicosis, artificial stone-associated silicosis is more rapidly progressive and lethal. Read More

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Case series analysis of eight underground tunnellers with chronic silicosis in Queensland.

Respirol Case Rep 2021 Jun 7;9(6):e00756. Epub 2021 May 7.

I Med Radiology Brisbane Queensland Australia.

Within Australia, chronic silicosis has been long thought of as being a well-controlled occupational lung disease. While recent cases of acute silicosis in artificial stone benchtop cutters have emerged, chronic silicosis within the general workforce population has not been recorded. Our case series describes the re-emergence of chronic silicosis amongst workers within the tunnelling industry representing the potential for a more widespread insidious occupational lung disease. Read More

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Respirable dust and crystalline silica exposure among different mining sectors in India.

Arch Environ Occup Health 2021 May 10:1-7. Epub 2021 May 10.

ICMR-National Institute of Occupational Health, Ahmedabad, Gujarat, India.

Silicosis is one of the major occupational lung diseases among miners worldwide. The objective of this study was to characterize respirable dust and crystalline silica from limestone, iron, and bauxite mines in India. In total, 86 personal dust samples were collected from limestone (n = 30), iron (n = 30), and bauxite (n = 26) mines using dust sampler. Read More

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An Unusual Esophageal Ulcerative Lesion Mimicking Esophageal Cancer.

Gastroenterology 2021 May 5. Epub 2021 May 5.

Department of Internal Medicine, E-Da Hospital/I-Shou University, Kaohsiung, Taiwan; School of Medicine, College of Medicine, I-Shou University, Kaohsiung, Taiwan. Electronic address:

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SPP1 derived from silica-exposed macrophage exosomes triggers fibroblast transdifferentiation.

Toxicol Appl Pharmacol 2021 Jul 4;422:115559. Epub 2021 May 4.

Department of Occupational Health and Environmental Health, College of Public Health, Zhengzhou University, Zhengzhou, 450001, Henan, China. Electronic address:

The occurrence and development of silicosis is related to the interaction of multiple cells through signal transmission caused by silica dust. Including inflammatory changes reduced by macrophages and phenotypic transdifferentiation reduced by lung fibroblasts. As a communication medium between cells, exosomes have become a hot research topic. Read More

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Do the successful revision surgery for humeral nonunion solve all the effects on health-related quality of life? A retrospective cohort study.

BMC Musculoskelet Disord 2021 May 5;22(1):414. Epub 2021 May 5.

Department of Orthopaedics and Trauma, Hong Hui Hospital, Xi'an Jiaotong University College of Medicine, No. 555, East Youyi Road, Shaanxi, 710000, Xi'an, China.

Background: The aim of this study is to evaluate the effects of successful revision operation on health quality of life(QoL) and functional outcome in humeral nonunion patients.

Methods: This retrospective study included 62 patients with humeral nonunion from Northwest China, who were admitted to the Department of Trauma Surgery, Honghui Hospital between March 2013 and September 2019. The following data were retrospectively evaluated: demographic data, clinical data, imaging findings, and treatment methods. Read More

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Ac-SDKP Attenuates Activation of Lung Macrophages and Bone Osteoclasts in Rats Exposed to Silica by Inhibition of TLR4 and RANKL Signaling Pathways.

J Inflamm Res 2021 27;14:1647-1660. Epub 2021 Apr 27.

Basic Medical College, Hebei Key Laboratory for Chronic Diseases, North China University of Science and Technology, Tangshan, Hebei Province, 063210, People's Republic of China.

Background: Silica-induced inflammatory activation is associated with silicosis and various non-respiratory conditions. The present study was designed to examine the anti-inflammatory effects of N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) on lung macrophages and bone osteoclasts after silica inhalation in rats.

Methods: Wistar rats and NR8383 and RAW 264. Read More

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Increased secretion of VEGF-C from SiO-induced pulmonary macrophages promotes lymphangiogenesis through the Src/eNOS pathway in silicosis.

Ecotoxicol Environ Saf 2021 Apr 29;218:112257. Epub 2021 Apr 29.

School of Public Health, North China University of Science and Technology, Tangshan, Hebei 063210, China; Hebei Key Laboratory of Organ Fibrosis, North China University of Science and Technology, Tangshan, Hebei 063210, China. Electronic address:

Silicosis, a type of lung inflammation and fibrosis caused by long-term inhalation of SiO particles, lacks effective treatment currently. Based on the results of our previous animal experiments, in lungs of SiO-induced silicosis rats, a large number of lymphatic vessels are generated in the early stage of inflammation, which is of great significance for the removal of dust and inflammatory mediators. Here, the molecular mechanism of lymphangiogenesis is further studied. Read More

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New Insights into Pathomechanisms and Treatment Possibilities for Lung Silicosis.

Int J Mol Sci 2021 Apr 17;22(8). Epub 2021 Apr 17.

Department of Physiology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, SK-03601 Martin, Slovakia.

Inhalation of silica particles is an environmental and occupational cause of silicosis, a type of pneumoconiosis. Development of the lung silicosis is a unique process in which the vicious cycle of ingestion of inhaled silica particles by alveolar macrophages and their release triggers inflammation, generation of nodular lesions, and irreversible fibrosis. The pathophysiology of silicosis is complex, and interactions between the pathomechanisms have not been completely understood. Read More

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Plasma Metabolic Profiling in Patients with Silicosis and Asbestosis.

J Occup Environ Med 2021 Apr 20. Epub 2021 Apr 20.

Department of Occupational Medicine and Toxicology, Clinical Center for Interstitial Lung Diseases, Beijing Chao-Yang Hospital, Capital Medical University, No. 8 Workers' Stadium South Road, Chao-Yang District, Beijing 100020, China (Zhou, Xue, Fan, Wu, Ma, Ye), Department of Occupational Diseases and Chemical Poisoning, the Fifth People's Hospital of Suzhou, the Affiliated Infectious Hospital of Soochow University, 10 Guangqian Road, Xiang-cheng District, Suzhou 215131, Jiangsu Province, China (Zhou).

Objectives: To explore the circulating metabolites and related pathways in silicosis and asbestosis exposure to different mineral dusts.

Methods: Plasma of 30 silicosis, 30 asbestosis, and 20 healthy controls was analyzed using liquid chromatography-mass spectrometry. Metabolic networks and the relevance of the identified metabolic derangements were explored. Read More

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Dahuang Zhechong Pills Suppress Silicosis Fibrosis Progression via p38 MAPK/TGF-1/Smad Pathway .

Evid Based Complement Alternat Med 2021 1;2021:6662261. Epub 2021 Apr 1.

College of Public Health, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China.

Background: Dahuang Zhechong pills (DHZCP) is a classic Chinese medicinal prescription in "Treatise on Cold Pathogenic and Miscellaneous Diseases (Shanghan Zabing Lun)," and it has the function of tonifying blood, nourishing Yin, and removing blood stasis. Previous studies have shown that DHZCP could alleviate SiO induced pulmonary fibrosis in mice. This study aims to further explore the preventive and therapeutic effects of DHZCP against silicosis fibrosis and the underlying mechanisms . Read More

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Occupational lung disease: A narrative review of lung conditions from the workplace.

Ann Med Surg (Lond) 2021 Apr 23;64:102245. Epub 2021 Mar 23.

Department of Medicine, Faculty of Medicine and Health Sciences, Kota Kinabalu, Sabah, Malaysia.

Occupational lung diseases are lung conditions caused or made worse by materials when a person is exposed to a workplace. The diagnosis of an occupational disease is important for workers' decision to continue work and for their eligibility under compensation programmes. We revisit the existing lung diseases that are closely associated with the occupation at the workplace namely occupational asthma, silicosis, black lung disease, farmers' lung disease, asbestos-linked disease, and hypersensitivity pneumonitis. Read More

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Transcriptomic analysis identifies upregulation of secreted phosphoprotein 1 in silicotic rats.

Exp Ther Med 2021 Jun 31;21(6):579. Epub 2021 Mar 31.

School of Public Health, Hebei Key Laboratory for Organ Fibrosis Research, North China University of Science and Technology, Tangshan, Hebei 063210, P.R. China.

Silicosis is caused by exposure to crystalline silica and the molecular mechanism of silicotic fibrosis remains unclear. Therefore, the present study investigated the mRNA profiles of rats exposed to crystalline silica. RNA-sequencing techniques were used to observe differential expression of mRNAs in silicotic rats induced by chronic inhalation of crystalline silica particulates. Read More

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Macrophage-derived exosomes mediate silica-induced pulmonary fibrosis by activating fibroblast in an endoplasmic reticulum stress-dependent manner.

J Cell Mol Med 2021 May 8;25(9):4466-4477. Epub 2021 Apr 8.

Department of Pathology, School of Basic Medical Science, Central South University, Changsha, China.

Macrophages play a key role in silicosis, and exosomes are potent mediators of intercellular communication. This suggests that macrophage-derived exosomes have a potential contribution to the pathogenesis of silicosis. To investigate whether macrophage-derived exosomes promote or inhibit lung fibrosis, in vitro, silica-exposed macrophage-derived exosomes (SiO -Exos) were collected and cocultured with fibroblasts. Read More

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Lipopolysaccharides promote pulmonary fibrosis in silicosis through the aggravation of apoptosis and inflammation in alveolar macrophages.

Open Life Sci 2020 18;15(1):598-605. Epub 2020 Aug 18.

Key Laboratory of Molecular Epidemiology of Hunan Province, Hunan Normal University, No. 371 Tongzipo Road, Changsha, 410013, Hunan, China.

Alveolar macrophages (AMs) play an important defensive role by removing dust and bacteria from alveoli. Apoptosis of AMs is associated with lung fibrosis; however, the relationship between this apoptotic event and environmental factors, such as the presence of lipopolysaccharides (LPSs) in the workplace, has not yet been addressed. To investigate whether exposure to LPS can exacerbate fibrosis, we collected AMs from 12 male workers exposed to silica and incubated them in the presence and absence of LPS for 24 h. Read More

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[Changes of neuron specific enolase in serum of patients with silicosis].

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2021 Mar;39(3):215-217

Binzhou Medical University, Yantai 264003, China.

To explore the changes of neuron specific enolase (NSE) concentration in serum samples of patients with silicosis. In January 2020, 455 cases of silicosis diagnosed in Yantaishan Hospital from January 2018 to December 2019 were collected, and 60 healthy cases and 120 cases of lung cancer were selected as the healthy group and the lung cancer group. The serum levels of NSE were detected by chemical immunofluorescence assay and compared. Read More

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