8,491 results match your criteria Silicosis


High sensitive lab-on-a-chip (LOC) immunoassay for early diagnosis of respiratory disease caused by respirable crystalline silica (RCS).

Anal Chem 2019 Apr 23. Epub 2019 Apr 23.

Respirable crystalline silica (RCS) produced in mining and construction industries can cause life-threatening diseases such as silicosis, lung cancer, or chronic obstructive pulmonary disease (COPD). These diseases could be more effectively treated and prevented if RCS-related biomarkers are identified and measured at an early stage of disease progression, which makes development of a point-of-care test (POCT) platform extremely desirable for early diagnosis. In this work, a new, high-sensitive lab-on-a-chip (LOC) immunoassay has been designed, developed and characterized for Tumor Necrosis Factor - α (TNF-α), a protein biomarker that causes lung inflammation due to RCS exposure. Read More

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http://dx.doi.org/10.1021/acs.analchem.9b00582DOI Listing

Effects of occupational exposure to respirable quartz dust on acute myocardial infarction.

Occup Environ Med 2019 Apr 22. Epub 2019 Apr 22.

Work and Health, Federal Institute for Occupational Safety and Health, Berlin, Germany.

Objectives: The aim of this study is to investigate the effects of occupational exposure to respirable quartz (RQ) on first acute myocardial infarction (AMI). RQ causes pulmonary diseases like silicosis and has also been linked to cardiovascular diseases. Inflammation is hypothesised as the underlying pathway. Read More

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http://dx.doi.org/10.1136/oemed-2018-105540DOI Listing

Reply to Accelerated Silicosis-An Emerging Epidemic Associated with Engineered Stone. Comment on Leso, V. et al. Artificial Stone-Associated Silicosis: A Systematic Review. 2019, 16(4), 568, doi:10.3390/ijerph16040568.

Int J Environ Res Public Health 2019 Apr 3;16(7). Epub 2019 Apr 3.

Section of Occupational Medicine, Department of Public Health, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy.

Our systematic review on artificial stone (AS)-associated silicosis and the related comment by Edwards underline the urgency to define effective strategies to assess and manage the risk of exposure to silica in workers involved in AS job tasks. Case screening programs may be important to fully understand the extent of the silicosis epidemic associated with AS and point out critical issues in workplace settings/practices that, by contributing to higher respirable crystalline exposure, favor the disease manifestation. This information may guide the identification of the most appropriate preventive measures in workplaces, especially regarding the administration of updated training and information courses, the definition of good working practices, and the application of targeted health surveillance programs. Read More

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http://dx.doi.org/10.3390/ijerph16071201DOI Listing
April 2019
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Accelerated Silicosis-An Emerging Epidemic Associated with Engineered Stone. Comment on Leso, V. et al. Artificial Stone Associated Silicosis: A Systematic Review. 2019, (4), 568, doi:10.3390/ijerph16040568.

Authors:
Graeme Edwards

Int J Environ Res Public Health 2019 Apr 2;16(7). Epub 2019 Apr 2.

The Work Doctor, Gold Coast, QLD 4214 Queensland, Australia.

The systematic review by Leso et al. (16 February 2019) is a timely contribution to the body of knowledge concerning silicosis. It highlights the lack of quality data necessary to inform both occupational health risk management and the clinical management of workers exposed to respirable crystalline silica. Read More

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http://dx.doi.org/10.3390/ijerph16071179DOI Listing
April 2019
2 Reads

Profiling long non-coding RNA changes in silica-induced pulmonary fibrosis in rat.

Toxicol Lett 2019 Apr 9;310:7-13. Epub 2019 Apr 9.

Shandong Academy of Occupational Health and Occupational Medicine, Ji'nan, Shandong, China; The University of Queensland, Queensland Alliance for Environmental Health Sciences (QAEHS), Brisbane, Queensland, Australia.

Silicosis is a kind of chronic and incurable lung fibrotic disease with pathogenesis and molecular mechanisms largely unknown. Mounting evidence suggests that long non-coding RNAs (lncRNAs) are involved in the pathogenesis of silicosis. However, how many lncRNAs involved in the pulmonary fibrosis remains to be elucidated. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03784274193008
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http://dx.doi.org/10.1016/j.toxlet.2019.04.003DOI Listing
April 2019
4 Reads

Silicosis And Sjögren's Syndrome.

Arch Bronconeumol 2019 Apr 8. Epub 2019 Apr 8.

Servicio de Medicina Interna, Hospital Clínico Universitario de Valladolid, Valladolid, España.

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http://dx.doi.org/10.1016/j.arbres.2019.02.026DOI Listing
April 2019
1 Read

[Prevalence of silicosis among Xiangyu railway construction workers in Nanchong from 2008-2007].

Authors:
R Xue Y Y Zan X D Liu

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2019 Feb;37(2):116-118

The Centers for Disease Control and Prevention in. Guangyuan city, Guangyuan 628017, China.

To analyze the prevalence of silicosis in the militias with contribution to the former Xiangyu Railway construction in Nanchong, China, from 2008 to 2017, and to provide a scientific basis for the future development of pneumoconiosis prevention and control strategies based on the current status. A database was established for the data of 11863 militias with contribution to the former Xiangyu Railway construction in Nanchong, China, who attended our hospital from 2008 to 2017, including 11485 males (96.81%) and 378 females (3. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1001-9391.2019.02.006DOI Listing
February 2019
3 Reads

[Expression changes of miRNA-29b-3p and miRNA-34c-3p in lung tissue of rats exposed to silica and A549 cells].

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2019 Feb;37(2):110-115

Shandong academy of medical science shand and Occopational Medical, Jinan 250062, China.

To investigate the role of microRNA-29b-3p (miRNA-29b-3p) and miRNA-34c-3p in the process of pulmonary fibrosis, we detected the expression levels of miRNA-29b-3p and miRNA-34c-3p in the lung tissue of rats exposed to silica and A549 cells. SPF male Wistar rats were randomly divided into 1, 7, 14, 21, 28 d control group and silica (SiO(2)) dusting group, with 6 rats in each group. One-time non-exposure method was used to infuse 1ml SiO(2) suspension. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1001-9391.2019.02.005DOI Listing
February 2019
2 Reads

Chromatin regulation by Histone H4 acetylation at Lysine 16 during cell death and differentiation in the myeloid compartment.

Nucleic Acids Res 2019 Mar 29. Epub 2019 Mar 29.

Nanomaterials and Nanotechnology Research Center (CINN-CSIC), Universidad de Oviedo-Principado de Asturias, Spain.

Histone H4 acetylation at Lysine 16 (H4K16ac) is a key epigenetic mark involved in gene regulation, DNA repair and chromatin remodeling, and though it is known to be essential for embryonic development, its role during adult life is still poorly understood. Here we show that this lysine is massively hyperacetylated in peripheral neutrophils. Genome-wide mapping of H4K16ac in terminally differentiated blood cells, along with functional experiments, supported a role for this histone post-translational modification in the regulation of cell differentiation and apoptosis in the hematopoietic system. Read More

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http://dx.doi.org/10.1093/nar/gkz195DOI Listing
March 2019
1 Read
9.112 Impact Factor

Paediatric sarcoidosis.

Paediatr Respir Rev 2019 Feb 19;29:53-59. Epub 2018 May 19.

Service de Pneumologie Pédiatrique et Centre de référence des maladies respiratoires rares, AP-HP, Hôpital Trousseau, Unité INSERM UMR-S933, Sorbonne Université, Paris, France. Electronic address:

Paediatric sarcoidosis is an extremely rare disease characterized by a granulomatous inflammation. The estimated incidence is 0.6-1. Read More

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http://dx.doi.org/10.1016/j.prrv.2018.05.003DOI Listing
February 2019
2 Reads

CircRNA-012091/PPP1R13B-Mediated Lung Fibrotic Response in Silicosis via ER Stress and Autophagy.

Am J Respir Cell Mol Biol 2019 Mar 25. Epub 2019 Mar 25.

Southeast University, Department of physiology, Nanjing, Jiangsu, China ;

Silicosis is a progressive fibrotic disease of lung tissue caused by long-term inhalation of SiO2. However, relatively few studies on the direct effects of SiO2 on lung fibroblasts have been performed. PPP1R13B is a major member of the apoptosis-stimulating proteins of the p53 family (ASPPs), but its role in pulmonary fibrosis is unclear. Read More

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http://dx.doi.org/10.1165/rcmb.2019-0017OCDOI Listing
March 2019
1 Read
3.985 Impact Factor

Lung cancer and residential radon in never-smokers: A pooling study in the Northwest of Spain.

Environ Res 2019 Mar 6;172:713-718. Epub 2019 Mar 6.

Department of Preventive Medicine and Public Health, University of Santiago de Compostela, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER en Epidemiología y Salud Pública, CIBERESP), Spain; Service of Preventive Medicine, University Hospital Complex of Santiago de Compostela, Spain.

Background: Using a pooled case-control study design, including only never-smokers, we have assessed the association of residential radon exposure with the subsequent occurrence of lung cancer. We also investigated whether residential radon poses a different risk specifically for adenocarcinoma.

Methods: We pooled individual data from different case-control studies conducted in recent years in Northwestern Spain which investigated residential radon and lung cancer. Read More

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http://dx.doi.org/10.1016/j.envres.2019.03.011DOI Listing
March 2019
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Association of respiratory integer and fractional-order models with structural abnormalities in silicosis.

Comput Methods Programs Biomed 2019 Apr 7;172:53-63. Epub 2019 Feb 7.

Biomedical Instrumentation Laboratory, Institute of Biology Roberto Alcantara Gomes, State University of Rio de Janeiro, Rio de Janeiro, Brazil; Laboratory of Clinical and Experimental Research in Vascular Biology (BioVasc), State University of Rio de Janeiro, Rio de Janeiro, Brazil. Electronic address:

Background And Objective: Integer and fractional-order models have emerged as powerful methods for obtaining information regarding the anatomical or pathophysiological changes that occur during respiratory diseases. However, the precise interpretation of the model parameters in light of the lung structural changes is not known. This study analyzed the associations of the integer and fractional-order models with structural changes obtained using multidetector computed tomography densitometry (MDCT) and pulmonary function analysis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01692607183160
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http://dx.doi.org/10.1016/j.cmpb.2019.02.003DOI Listing
April 2019
4 Reads

Silicosis: Diagnosis and Medicolegal Implications.

J Forensic Sci 2019 Mar 22. Epub 2019 Mar 22.

School of Medicine and Public Health, University of Wisconsin, 750 Highland Ave, Madison, WI, 53726.

Despite well-publicized sources of occupational hazard, silicosis continues to threaten industrial workers in the United States. We performed a retrospective search of the University of Wisconsin electronic pathology database to retrieve autopsy cases of silicosis and collaborated with the Wisconsin Department of Health Services to obtain statewide epidemiologic data regarding silicosis morbidity/mortality since 2003. Three silicosis autopsy cases were retrieved: all were men with ≥ 30 years of occupational crystalline silica exposure and similar histologic features of collagenous pulmonary nodules with admixed refractile particles. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/1556-4029.14
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http://dx.doi.org/10.1111/1556-4029.14048DOI Listing
March 2019
6 Reads

Frequency of Depression-Related Symptoms in Caregivers of Patients with Silicosis.

J Healthc Eng 2019 11;2019:6035920. Epub 2019 Feb 11.

Department of Occupational and Environmental Health, Xiangya School of Public Health, Central South University, 410078 Changsha, China.

Background: Few studies have evaluated depression in female caregivers of patients with silicosis. Thus, the aim of this study was to estimate the prevalence of depression in such caregivers and to clarify the factors associated with symptoms of depression.

Methods: Depressive symptoms were assessed using the Center for Epidemiologic Studies Depression Scale (CES-D). Read More

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http://dx.doi.org/10.1155/2019/6035920DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388330PMC
February 2019
1 Read

[International incidence trend of coal workers' pneumoconiosis and silicosis].

Authors:
B W Cheng M Su

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2019 Jan;37(1):75-78

Shantou University Medical College, Shantou 515041, China.

Pneumoconiosis is a group of occupational disease that seriously threaten the health of workers, which was regard as incurable for the irreversibility of pulmonary fibrotic lesions. It was successfully controlled in a few countries but resurgent in resent years. At the same time, the silicosis in the emerging industries has gradually appeared in many countries. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1001-9391.2019.01.020DOI Listing
January 2019
1 Read

[Incidence and trend of occupational diseases in a district of Beijing from 2004 to 2017].

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2019 Jan;37(1):46-49

Shunyi District of Beijing Center for Disease Prevention and Control, Beijing 101300, China.

To investigate the incidence of occupational diseases in a District of Beijing, from 2004 to 2017 and to analyze the distribution characteristics and incidence trends of occupational diseases. The data of confirmed occupational disease cases data in the occupational disease and occupational health information monitoring system in a district of Beijing from 2004~2017 were collected to analyze the incidence and trends of occupational diseases. In 2004~2017, a total of 161cases of occupational diseases were reported in a district of Beijing, mainly pneumoconiosis (113 cases, 70. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1001-9391.2019.01.010DOI Listing
January 2019
1 Read

[Repair effect of adipose-derived mesenchymal stem cells on lung injury in rats exposed to silica].

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2019 Jan;37(1):20-25

Shandong Academy of Occupational Health and Occupational Medicine, Shandong Academy of Medical Sciences, Jinan 250062, China; School of Medicine and Life Sciences, Shandong Academy of Medical Sciences, Jinan University, Jinan 250062, China.

To observe the repairing effect of adipose mesenchymal stem cells (ADSCs) on lung injury induced by silica in rats. Primary ADSCs-GFP was obtained from rats. ADSCs-GFP was injected into tail vein of silicosis model rats. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1001-9391.2019.01.004DOI Listing
January 2019
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[Preliminary analysis of differential expression of miRNA-423-5p and miRNA-26a-5p in lung tissue of early silicotic rats].

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2019 Jan;37(1):7-12

Shandong Academy of Medical Science, Shandong Academy of Occupational Medicine, Jinan 250062, China.

To screen the changes of microRNA (miRNA) expression profiles in lung tissues of early silicosis rats, and provide a basis for functional analysis of differential microRNA. SPF Wistar male rats were randomly divided into a negative control group and SiO(2)-exposed groups, with 30 rats in each group. The model of silicosis in rats was established by intratracheal instillation of 1 ml SiO(2) suspension, and the control rats were treated with 1mL in the same way to sterilize normal saline. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1001-9391.2019.01.002DOI Listing
January 2019
1 Read

Silicosis in Artificial Quartz Conglomerate Workers.

Arch Bronconeumol 2019 Mar 14. Epub 2019 Mar 14.

Área del Pulmón, Hospital Universitario Central de Asturias (HUCA), Facultad de Medicina, Universidad de Oviedo, Oviedo, Asturias, España.

Introduction: Silicosis is a chronic progressive disease caused by inhalation of crystalline silica. Most cases develop in underground mine workers and in subjects involved in the extraction of natural stone (slate and granite). In view of the progressive emergence of new cases of silicosis in artificial quartz conglomerate workers, we performed a study to analyze the characteristics of silicosis produced by this new agent in Spain. Read More

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http://dx.doi.org/10.1016/j.arbres.2019.01.017DOI Listing
March 2019
3 Reads

The world is failing on silicosis.

Lancet Respir Med 2019 Apr 11;7(4):283. Epub 2019 Mar 11.

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http://dx.doi.org/10.1016/S2213-2600(19)30078-5DOI Listing
April 2019
1 Read

Female workers' silicosis diagnosis delayed due to gender bias.

Occup Med (Lond) 2019 Mar 14. Epub 2019 Mar 14.

Department of Pulmonary Diseases, School of Medicine, Atatürk University, Erzurum, Turkey.

After excluding alternative explanations, a silicosis diagnosis is based on the combination of appropriate silica exposure history and compatible clinical, radiological and occasionally pathological findings. Not taking appropriate occupational history by a physician may cause a misdiagnosis or underdiagnosis of silicosis. Herein, we present a female worker in a small-scale sandblasting factory who worked as a controller. Read More

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http://dx.doi.org/10.1093/occmed/kqz019DOI Listing
March 2019
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Alterations in the gut microbiota of patients with silica-induced pulmonary fibrosis.

J Occup Med Toxicol 2019 4;14. Epub 2019 Mar 4.

Department of Occupational and Environmental Health, Xiangya School of Public Health, Changsha, 410078 China.

Silicosis resulting from silica exposure is a global occupational disease characterized by severe pathological changes in progressive pulmonary fibrosis. Previous evidence has indicated that dysbiosis of the gut microbiota occurs after environmental dust exposure and is associated with certain diseases. The aims of this study are to elucidate the compositional and functional characteristics of the gut microbiota in early-stage silicosis and to understand their influence on pulmonary fibrosis. Read More

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https://occup-med.biomedcentral.com/articles/10.1186/s12995-
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http://dx.doi.org/10.1186/s12995-019-0225-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399897PMC
March 2019
8 Reads

Can treatment outcomes of latent TB infection and TB in silicosis be improved?

J Thorac Dis 2019 Jan;11(1):E8-E10

Stanley Ho Centre for Emerging Infectious Diseases, Faculty of Medicine, The University of Hong Kong, Hong Kong, China.

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http://dx.doi.org/10.21037/jtd.2018.12.113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384370PMC
January 2019
2 Reads

Usefulness of Magnetic Resonance in Suspected Lung Cancer in Silicosis Patients.

Arch Bronconeumol 2019 Mar 9. Epub 2019 Mar 9.

Servicio de Neumología Preventiva, Instituto Nacional de Silicosis, Oviedo, España.

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https://linkinghub.elsevier.com/retrieve/pii/S03002896193002
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http://dx.doi.org/10.1016/j.arbres.2019.01.012DOI Listing
March 2019
6 Reads
1.816 Impact Factor

Estimated impact of World Health Organization latent tuberculosis screening guidelines in a low TB incidence region: retrospective cohort study.

Clin Infect Dis 2019 Mar 11. Epub 2019 Mar 11.

British Columbia Centre for Disease Control, Vancouver, Canada.

Background: Latent tuberculosis (LTBI) screening and treatment is a key component of the World Health Organization (WHO) EndTB Strategy, but the impact of LTBI screening and treatment at a population level is unclear. We aimed to estimate the impact of LTBI screening and treatment in a population of migrants to British Columbia (BC), Canada.

Methods: This retrospective cohort included all individuals (N=1,080,908) who immigrated to Canada as permanent residents between 1985 and 2012 and were resident in BC at any time up to 2013. Read More

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https://academic.oup.com/cid/advance-article/doi/10.1093/cid
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http://dx.doi.org/10.1093/cid/ciz188DOI Listing
March 2019
7 Reads
8.886 Impact Factor

Silicosis Caused by Artificial Quartz Conglomerates: Keys to Controlling an Emerging Disease.

Arch Bronconeumol 2019 Mar 5. Epub 2019 Mar 5.

Servicio de Neumología, Hospital Universitario Puerta del Mar, Cádiz, España; Servicio de Neumología, Hospital Universitario Puerto Real, Puerto Real, Cádiz, España.

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http://dx.doi.org/10.1016/j.arbres.2019.01.015DOI Listing
March 2019
2 Reads

Topical application of haemoglobin: a safety study.

J Wound Care 2019 Mar;28(3):148-153

Division of Plastic, Aesthetic and Reconstructive Surgery, Department of Surgery, Medical University of Graz, Graz, Austria.

Objective:: Ischaemia is one of the biggest problems in wound healing. It causes chronic wounds and also prevents normal wound healing because the tissue is oxygen deprived. Most oxygen-supplying therapies are only feasible in a clinical setting, but topical haemoglobin applications, such as Granulox, can be used in a non-clinical setting. Read More

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http://dx.doi.org/10.12968/jowc.2019.28.3.148DOI Listing
March 2019
4 Reads

Australia reports on audit of silicosis for stonecutters.

Authors:
Tony Kirby

Lancet 2019 03;393(10174):861

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http://dx.doi.org/10.1016/S0140-6736(19)30478-7DOI Listing
March 2019
2 Reads

The emerging roles of a novel CCCH-type zinc finger protein, ZC3H4, in silica-induced epithelial to mesenchymal transition.

Toxicol Lett 2019 Jun 1;307:26-40. Epub 2019 Mar 1.

Department of Physiology, School of Medicine, Southeast University, Nanjing, Jiangsu, 210009, China; Department of Respiration, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, 210009, China; Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing, Jiangsu, 210009, China. Electronic address:

Background: The epithelial to mesenchymal transition (EMT) contributes to fibrosis during silicosis. Zinc finger CCCH-type containing 4 protein (ZC3H4) is a novel CCCH-type zinc finger protein that activates inflammation in pulmonary macrophages during silicosis. However, whether ZC3H4 is involved in EMT during silicosis remains unclear. Read More

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http://dx.doi.org/10.1016/j.toxlet.2019.02.014DOI Listing
June 2019
5 Reads

Ac-SDKP increases α-TAT 1 and promotes the apoptosis in lung fibroblasts and epithelial cells double-stimulated with TGF-β1 and silica.

Toxicol Appl Pharmacol 2019 Apr 28;369:17-29. Epub 2019 Feb 28.

Basic Medical College, Hebei Medical University, Shijiazhuang, China. Electronic address:

Crystalline silica (SiO) particles have very strong toxicity to the lungs, and silicosis is an excessive pulmonary interstitial remodeling disease that follows persistent SiO injury. We showed here that DNA double strand breaks (DSBs) and apoptosis were aggravated during rat silicosis induced by SiO exposure. Ac-SDKP attenuates lung parenchymal distortion and collagen deposition, and decreases the expression of γH2AX, p21, and cleaved caspase-3, as well as improves the reduction of pulmonary function caused by silicosis. Read More

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http://dx.doi.org/10.1016/j.taap.2019.02.015DOI Listing
April 2019
2 Reads

[Lung fibrosis and changes in autophagy-related proteins in rats exposed to silica dust].

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2018 Dec;36(12):890-895

School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Shandong Academy of Occupational Health and Occupational Medicine, Jinan 250062, China.

To explore the changes in the autophagy marker microtubule-associated protein 1 light chain 3 (LC3) and yeast autophagy-related gene 6 (Beclin1) in rat lungs exposed to free silica (SiO(2)) dust for different periods. A total of 72 male specific pathogen-free Wistar rats were randomly divided into solvent control group and SiO(2) model group. The SiO(2) model group received one-time non-exposed intratracheal instillation of suspension of SiO(2) particles to establish a model of silicosis. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1001-9391.2018.12.002DOI Listing
December 2018
2 Reads

Those Who Don't Return: Improving Efforts to Address Tuberculosis Among Former Miners in Southern Africa.

New Solut 2019 Feb 21:1048291119832082. Epub 2019 Feb 21.

2 University of North Carolina at Chapel Hill, NC, USA.

Despite increasing awareness regarding the role of oscillating migration in the mining industry as a major driving force in the spread of tuberculosis (TB) throughout southern Africa, very little work has focused on the historical and contextual factors which may contribute to former migrant miners' present-day risk of TB. Most research regarding migration-related and occupational influences on TB has been done on current miners still employed by the mining industry. Through both a historical and contemporary lens, this paper explores and elucidates the need to address the TB epidemic among former migrant mine workers and provides considerations to improve current interventions among this critical population. Read More

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http://dx.doi.org/10.1177/1048291119832082DOI Listing
February 2019
1 Read

Carvedilol attenuates experimentally induced silicosis in rats via modulation of P-AKT/mTOR/TGFβ1 signaling.

Int Immunopharmacol 2019 May 20;70:47-55. Epub 2019 Feb 20.

Dep. of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt. Electronic address:

Silicosis is a well acknowledged occupational lung disorder with considerable negative impact on the patients' quality of life. Various signaling pathways have been reported to interplay in the pathogenesis of pulmonary fibro-proliferative disorders; of which, P-AKT/mTOR signaling pathway. The current study highlights the potential pulmonary protective effect of carvedilol; a non-selective α/β blocker against experimental silicosis-induced in rats by the intranasal installation of silica (50 mg/rat, 1 ml 0. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.02.011DOI Listing
May 2019
2 Reads

Application of protein chip combined with SELDI-TOF-MS detection to investigate serum protein expression in patients with silicosis fibrosis.

Exp Ther Med 2019 Mar 11;17(3):2172-2184. Epub 2019 Jan 11.

Endocrinology Department, The Fifth Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830011, P.R. China.

The present study aimed to observe the identification of biomarkers of silicosis based on the differentially expressed serum proteins between normal healthy individuals and patients with silicosis fibrosis. A total number of 20 patients with clinically diagnosed silicosis were screened, which were designated as the foundation treatment group. In addition, 20 age-matched healthy patients attending a check-up at the physical examination department were selected. Read More

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http://dx.doi.org/10.3892/etm.2019.7166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364189PMC
March 2019
1 Read

Artificial Stone Associated Silicosis: A Systematic Review.

Int J Environ Res Public Health 2019 02 16;16(4). Epub 2019 Feb 16.

Section of Occupational Medicine, Department of Public Health, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy.

Silicosis is a progressive fibrotic lung disease that is caused by the inhalation of respirable crystalline silica. Due to its high silica content, artificial stone (AS) can become a possible source of hazardous dust exposure for workers that are employed in the manufacturing, finishing, and installing of AS countertops. Therefore, the aim of this review was to verify the association between AS derived silica exposure and silicosis development, and also then define the pathological characteristics of the disease in relation to specific work practices and preventive and protective measures that were adopted in the workplace. Read More

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http://dx.doi.org/10.3390/ijerph16040568DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406954PMC
February 2019
5 Reads

Asbestosis and silicosis hospitalizations in Italy (2001-2015): results from the National Hospital Discharge Registry.

Eur J Public Health 2019 Feb 7. Epub 2019 Feb 7.

Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, Italian National Workers' Compensation Authority (INAIL), Rome, Italy.

Background: This work is aimed at evaluating the quality of Italian hospitalizations data about asbestosis and silicosis, assessing the impact of these diseases on the national health system and providing advice related to public health.

Methods: Italian hospital discharge data (2001-15) with diagnosis of asbestosis or silicosis were analysed by the multiple correspondence analysis and diseases epidemics were evaluated through hospitalization rates.

Results: Hospitalizations were concentrated in the northwestern area, referred mainly to males and oldest people, the most treated tumors were lung cancer and mesothelioma (for asbestosis) and cares were aimed at reducing symptoms and increasing blood oxygenation. Read More

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http://dx.doi.org/10.1093/eurpub/ckz003DOI Listing
February 2019
3 Reads

Whole-lung lavage for severe pulmonary alveolar proteinosis assisted by veno-venous extracorporeal membrane oxygenation: a case report.

Can J Respir Ther 2018 Dec 5;55(1). Epub 2018 Dec 5.

Department of Anesthesiology, Centro Hospitalar São João, Porto, Portugal.

Pulmonary alveolar proteinosis (PAP) is a rare pathology characterized by accumulation of phospholipoproteinaceous material within the alveoli. The evolution of PAP is variable and treatment modalities are limited. Pharmacological therapeutic targets are being actively developed, but whole-lung lavage (WLL), first described in the 1960s, remains the cornerstone of therapy. Read More

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http://dx.doi.org/10.29390/cjrt-2018-019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345579PMC
December 2018
6 Reads

Aluminum in the lungs of Ontario hardrock miners.

Authors:
Dave K Verma

Arch Environ Occup Health 2019 Feb 11:1-4. Epub 2019 Feb 11.

a Department of Family Medicine and Program in Occupational Health & Environmental Medicine , McMaster University , Hamilton , ON , Canada.

The objective of this study was to determine the concentration of aluminum in the autopsied lungs of eight hardrock miners. These miners had inhaled McIntyre Powder (a mixture of aluminum and aluminum oxide) as a prophylaxis against silicosis. The study involved chemical analysis of lungs, where each whole lung was divided horizontally into three sections and analyzed by atomic absorption spectrophotometer equipped with a graphite furnace. Read More

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http://dx.doi.org/10.1080/19338244.2019.1574703DOI Listing
February 2019
2 Reads

Mycobacterium Tuberculosis infection among the elderly in 20 486 rural residents aged 50-70 years in Zhongmu County, China.

Clin Microbiol Infect 2019 Feb 7. Epub 2019 Feb 7.

NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, and Center for Tuberculosis Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. Electronic address:

Objectives: Elderly individuals in rural China have been known to be at increased risk of contracting tuberculosis (TB) and developing active disease. This study aims to estimate the burden of mycobacterium tuberculosis (MTB) infection and to identify potential targeted subgroups for infection control.

Methods: As part of the investigation of an interventional study, 50- to 70-year-old rural residents in Zhongmu County were targeted for MTB infection testing using QuantiFERON-TB Gold In-Tube (QFT). Read More

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http://dx.doi.org/10.1016/j.cmi.2019.01.021DOI Listing
February 2019
8 Reads

Characteristics and Trends of Pneumoconiosis in the Jiangsu Province, China, 2006⁻2017.

Int J Environ Res Public Health 2019 02 2;16(3). Epub 2019 Feb 2.

Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 211166, China.

This study aims to describe the characteristics and trends of pneumoconiosis in the Jiangsu Province, China, and provide information for the occupational diseases control. We collected and analyzed the data of pneumoconiosis cases reported annually from 2006 to 2017. The information of the cases mainly includes case distributions, clinical types and stages, enterprise types and scales, as well as diagnosis age and exposure duration. Read More

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http://dx.doi.org/10.3390/ijerph16030437DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388371PMC
February 2019
3 Reads

Prevalence of pneumoconiosis among young adults aged 24-44 years in a heavily industrialized province of China.

J Occup Health 2019 Jan;61(1):73-81

Hebei Provincial Center for Disease Control and Prevention, Shijiazhuang, China.

Objectives: The purposes of this study were to clarify (i) the prevalence of pneumoconiosis among young adults and (ii) the factors associated with pneumoconiosis among young adults to explore targeted solution for control of pneumoconiosis among young adults (aged 24-44 years).

Methods: The new cases diagnosed from 2001 to 2015 (extracted from the National Occupational Disease and Occupational Health Information Monitoring System) were involved in this research, including information of employer, patient's name, date of birth, gender, date of diagnosis, first year of dust exposure, duration of exposure, aggregation etc RESULTS: A total of 1519 pneumoconiosis cases were diagnosed among young adults (21.6% of overall cases). Read More

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http://doi.wiley.com/10.1002/1348-9585.12029
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http://dx.doi.org/10.1002/1348-9585.12029DOI Listing
January 2019
6 Reads

Immunity to the Dual Threat of Silica Exposure and .

Front Immunol 2018 9;9:3069. Epub 2019 Jan 9.

Division of Immunology, Department of Pathology and Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.

Exposure to silica and the consequent development of silicosis are well-known health problems in countries with mining and other dust producing industries. Apart from its direct fibrotic effect on lung tissue, chronic and immunomodulatory character of silica causes susceptibility to tuberculosis (TB) leading to a significantly higher TB incidence in silica-exposed populations. The presence of silica particles in the lung and silicosis may facilitate initiation of tuberculous infection and progression to active TB, and exacerbate the course and outcome of TB, including prognosis and survival. Read More

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https://www.frontiersin.org/article/10.3389/fimmu.2018.03069
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http://dx.doi.org/10.3389/fimmu.2018.03069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334662PMC
January 2019
14 Reads

Lipid Uptake by Alveolar Macrophages Drives Fibrotic Responses to Silica Dust.

Sci Rep 2019 Jan 23;9(1):399. Epub 2019 Jan 23.

School of Public Health, North China University of Science and Technology, Tangshan, Hebei, 063210, China.

Silicosis is a common occupational disease and represents a significant contributor to respiratory morbidity and mortality worldwide. Lipid-laden macrophages, or foam cells, are observed in the lungs of patients with silicosis but the mechanisms mediating their formation remain poorly understood. In this study, we sought to elucidate the mechanisms by which silica promotes foam cell formation in the lung, and to determine whether uptake of lipids alone is sufficient to drive TGF-β production by alveolar macrophages. Read More

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http://dx.doi.org/10.1038/s41598-018-36875-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344530PMC
January 2019
2 Reads

Functional variant of the carboxypeptidase M (CPM) gene may affect silica-related pneumoconiosis susceptibility by its expression: a multistage case-control study.

Occup Environ Med 2019 Mar 23;76(3):169-174. Epub 2019 Jan 23.

Jiangsu Provincial Key Laboratory of Geriatrics, Department of Geriatrics, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.

Objectives: In a genome-wide association study, we discovered chromosome 12q15 (defined as rs73329476) as a silica-related pneumoconiosis susceptibility region. However, the causal variants in this region have not yet been reported.

Methods: We systematically screened eight potentially functional single-neucleotide polymorphism (SNPs) in the genes near rs73329476 (carboxypeptidase M () and cleavage and polyadenylation specific factor 6 ()) in a case-control study including 177 cases with silicosis and 204 healthy controls, matched to cases with years of silica dust exposure. Read More

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http://dx.doi.org/10.1136/oemed-2018-105545DOI Listing
March 2019
3 Reads
3.267 Impact Factor

Neutrophil to lymphocyte ratio and platelet to lymphocyte ratio as haematological indices of inflammatory response in ceramic workers' silicosis.

Clin Respir J 2019 Mar 3;13(3):159-165. Epub 2019 Feb 3.

Department of Chest Diseases, Occupational and Environmental Diseases Hospital, Ankara, Turkey.

Introduction: Occupational exposure to crystalline silica over time may result in silicosis: a fatal, irreversible occupational disease leading to lung function impairment. A complex inflammatory process, excessive accumulation of mesenchymal cells and collagen production are the primary mechanisms underlying silicosis. Neutrophil to lymphocyte ratio (NLR) and the platelet to lymphocyte ratio (PLR) have emerged as representative indices of systemic inflammation. Read More

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http://dx.doi.org/10.1111/crj.12997DOI Listing
March 2019
7 Reads

Clinical Characteristics and Etiologies of Miliary Nodules in the US: A Single-Center Study.

Am J Med 2019 Jan 16. Epub 2019 Jan 16.

Divisions of Critical Care, Pulmonary and Sleep Medicine, Department of Internal Medicine. Electronic address:

Background: Miliary nodules have been typically described as a radiological manifestation of disseminated tuberculosis. However, miliary nodules are known to occur in a wide variety of conditions. The primary objective of the study was to identify clinical characteristics and etiologies of miliary nodules within our institution. Read More

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http://dx.doi.org/10.1016/j.amjmed.2018.12.030DOI Listing
January 2019
4 Reads

Aberrant expression of miR-125a-3p promotes fibroblast activation via Fyn/STAT3 pathway during silica-induced pulmonary fibrosis.

Toxicology 2019 Feb 15;414:57-67. Epub 2019 Jan 15.

Department of Occupational Medical and Environmental Health, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, China. Electronic address:

Various miRNAs are dysregulated during initiation and progression of pulmonary fibrosis. However, their function remains limited in silicosis. Here, we observed that miR-125a-3p was downregulated in silica-induced fibrotic murine lung tissues. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0300483X183047
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http://dx.doi.org/10.1016/j.tox.2019.01.007DOI Listing
February 2019
10 Reads
3.621 Impact Factor

Silicosis prevalence and incidence among Medicare beneficiaries.

Am J Ind Med 2019 Mar 18;62(3):183-191. Epub 2019 Jan 18.

Surveillance Branch, Respiratory Health Division, National Institute for Occupational Safety and Health (NIOSH), Centers for Disease Control and Prevention (CDC), Morgantown, West Virginia.

Introduction: Existing epidemiologic information on silicosis relies on mortality data.

Methods: We analyzed health insurance claims and enrollment information from 49 923 987 fee-for-service (FFS) Medicare beneficiaries aged ≥65 from 1999 to 2014. Three different definitions were developed to identify silicosis cases and results are presented as ranges of values for the three definitions. Read More

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http://dx.doi.org/10.1002/ajim.22944DOI Listing
March 2019
3 Reads