8,417 results match your criteria Silicosis


Outcomes after Lung Transplantation for Patients with Occupational Lung Diseases.

Clin Transplant 2018 Dec 2:e13460. Epub 2018 Dec 2.

Division of Lung Failure and Lung Transplantation, Lewis Katz School of Medicine at Temple University, Philadelphia, PA.

Occupational lung diseases (OLD) including silicosis, asbestosis, and pneumoconiosis progress to end stage lung disease requiring lung transplantation (LT). Prognosis and treatment of OLDs are poorly understood and a paucity of data exists regarding LT outcomes. Additionally, transplant operative complexity for patients with OLD is high. Read More

View Article
December 2018
3 Reads

Silicosis, sarcoidosis and systemic sclerosis in the same patient.

Med Clin (Barc) 2018 Nov 27. Epub 2018 Nov 27.

Unidad de Enfermedades Sistémicas, Reumatología, Hospital General de Granollers, Granollers, Barcelona, España.

View Article
November 2018

Multiorgan accelerated silicosis misdiagnosed as sarcoidosis in two workers exposed to quartz conglomerate dust.

Occup Environ Med 2018 Dec 4. Epub 2018 Dec 4.

Department of Cardiologic, Thoracic and Vascular Sciences, University of Padova, Padova, Italy.

Introduction: Clusters of silicosis cases have been reported in the fabrication of quartz conglomerate, a new high-silica-content artificial stone for kitchen and bathroom benchtops (countertops).

Aim: We describe two cases of accelerated-type silicosis with hepatic granulomas arising in workers exposed to artificial quartz conglomerates.

Methods: A confident diagnosis of multiorgan silicosis was based on high level of respirable silica in the workplace, typical radiological alterations in chest high-resolution CT, histological findings in the lung and liver, and detection of silica crystals in both tissues by phase-contrast polarising light microscopy and scanning electron microscopy and energy dispersive spectroscopy. Read More

View Article
December 2018

Targeted migration of bone marrow mesenchymal stem cells inhibits silica-induced pulmonary fibrosis in rats.

Stem Cell Res Ther 2018 Dec 4;9(1):335. Epub 2018 Dec 4.

Department of Occupational and Environmental Health, School of Public Health, Capital Medical University, No. 10, Xi toutiao outside You anmen, Beijing, 100069, China.

Background: Silicosis is a common occupational disease, characterized by silicotic nodules and diffuse pulmonary fibrosis. We demonstrated an anti-fibrotic effect of bone marrow mesenchymal stem cells (BMSCs) in silica-induced lung fibrosis. In the present study, we sought to clarify the homing ability of BMSCs and the specific mechanisms for their effects. Read More

View Article
December 2018

Silicosis in underground miners in Lubumbashi, Democratic Republic of the Congo: 27 cases.

Med Sante Trop 2018 Nov 29. Epub 2018 Nov 29.

Institute for work and health, Service of Occupational Medecine, University of Lausanne and Geneva 1066 Epalinges-Lausanne, Suisse.

Silicosis is one of the most prevalent occupational lung diseases and a public health problem throughout the world. Underground miners of copper and cobalt are exposed to the dust of these minerals and thus to the risk of developing silicosis. The objective of this report was to describe a series of silicosis cases in miners exposed to mineral dusts at a mining company operating since the colonial era in Lubumbashi, Katanga province, in the Democratic Republic of the Congo (DRC). Read More

View Article
November 2018

Silicosis and lung cancer: current perspectives.

Lung Cancer (Auckl) 2018 26;9:91-101. Epub 2018 Oct 26.

Cancer and Inflammation Program, National Cancer Institute, Frederick, MD 21702, USA,

"Silica" refers to crystalline particles formed by the combination of silicon with oxygen. Inhalation of silica particles promotes the development of pulmonary fibrosis that over prolonged periods increases the risk of lung cancer. The International Agency for Research on Cancer (IARC) classified crystalline silica as a human carcinogen in 1997. Read More

View Article
October 2018

Pneumatic rock drill vs. electric rotary hammer drill: Productivity, vibration, dust, and noise when drilling into concrete.

Appl Ergon 2019 Jan 13;74:31-36. Epub 2018 Aug 13.

Department of Environmental Health Sciences, University of Michigan, Ann Arbor, MI, USA.

Objectives: Both pneumatic rock drills and electric rotary hammer drills are used for drilling large holes (e.g., 10-20 mm diameter) into concrete for structural upgrades to buildings, highways, bridges, and airport tarmacs. Read More

View Article
January 2019
1 Read

[Causes of mediastinal/hilar granulomatous lymphadenitis].

Tuberk Toraks 2018 Sep;66(3):212-216

Department of Pathology, Faculty of Medicine, Karadeniz Teknik University, Trabzon, Turkey.

Introduction: Granulomatous lung disease (GLD) is caused by a wide range of conditions and it is challenge for pulmonologist. A detailed history of exposures is fundamental in GDL and has been found pivotal to reach a precise diagnosis.

Materials And Methods: Between September 2014 and December 2016, the distribution of patients diagnosed with granulomatous lymphadenitis in the mediastinal/hilar lymph nodes by endobronchial ultrasound (EBUS) or mediastinoscopy was analyzed. Read More

View Article
September 2018
6 Reads

miR-542-5p Attenuates Fibroblast Activation by Targeting Integrin α6 in Silica-Induced Pulmonary Fibrosis.

Int J Mol Sci 2018 Nov 22;19(12). Epub 2018 Nov 22.

Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 210029, China.

Silicosis is a very serious occupational disease and it features pathological manifestations of inflammatory infiltration, excessive proliferation of fibroblasts and massive depositions of the extracellular matrix in the lungs. Recent studies described the roles of a variety of microRNAs (miRNAs) in fibrotic diseases. Here, we aimed to explore the potential mechanism of miR-542-5p in the activation of lung fibroblasts. Read More

View Article
November 2018
3 Reads
2.860 Impact Factor

A Rare Cause of Dysphagia and Cough: Bronchoesophageal Fistula from Silicosis.

ACG Case Rep J 2018 7;5:e77. Epub 2018 Nov 7.

Department of Internal Medicine, James J. Peters VA Medical Center, Bronx, NY.

Dysphagia and cough in an older male smoker raise concern for malignancy. However, a history of environmental exposures led to a much more interesting diagnosis in this case of pneumoconiosis due to silicosis. Silicosis is an uncommon pulmonary disease with rare associated gastrointestinal symptoms. Read More

View Article
November 2018
4 Reads

Role of SOD3 in silica-related lung fibrosis and pulmonary vascular remodeling.

Respir Res 2018 Nov 20;19(1):221. Epub 2018 Nov 20.

Department of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, University of Louisville, 505 S. Hancock Street, CTR Bldg., room 524, Louisville, KY, 40202, USA.

Background: Work-place exposure to silica dust may lead to progressive lung inflammation culminating in the development of silicosis, an irreversible condition that can be complicated by onset of pulmonary hypertension (PH). The molecular mechanisms leading to the development of PH and lung fibrosis in response to silica are not well understood. Oxidant/antioxidant imbalance in the lung may promote fibroproliferation and vascular smooth muscle proliferation, ultimately leading to the development of PH. Read More

View Article
November 2018
5 Reads

Focusing on Coal Workers' Lung Diseases: A Comparative Analysis of China, Australia, and the United States.

Int J Environ Res Public Health 2018 Nov 16;15(11). Epub 2018 Nov 16.

Sustainable Minerals Institute, The University of Queensland, Brisbane 4072, Australia.

China has high and increasing annual rates of occupational lung diseases such as pneumoconiosis and silicosis. In contrast, Australia and the United States of America (USA) have greatly lowered their annual rates of lung diseases since the 1970s. This paper systematically compared and analysed the multi-elements of coal dust management and health management in these three countries to provide a reference for China. Read More

View Article
November 2018
1 Read

Exposure‒response relationships for silicosis and its progression in industrial sand workers.

Scand J Work Environ Health 2018 Nov 18. Epub 2018 Nov 18.

Medical Biostatistics Unit, University of Vermont Larner College of Medicine, 105 Carrigan Dr., Burlington, VT 05405, USA.

Objectives This study aimed to characterize the relationship between radiographic silicosis and exposure to respirable quartz and determine how exposure affects disease progression. Methods Surveillance chest radiographs from a cohort of 1902 workers were examined to identify 67 cases of radiographic silicosis and 167 matched controls. Exposures were estimated by linking work histories to a job exposure matrix (JEM) based on samples collected by the participating companies and historical estimates. Read More

View Article
November 2018
1 Read

Shorter telomere length and DNA hypermethylation in peripheral blood cells of coal workers.

Mutat Res 2018 Dec 28;836(Pt B):36-41. Epub 2018 Mar 28.

Laboratory of Genetic Toxicology, Postgraduate Program in Molecular and Cell Biology Applied to Health, Lutheran University of Brazil (ULBRA), Canoas, RS, Brazil. Electronic address:

Coal is a mixture of several chemicals, mainly inorganic elements and polycyclic aromatic hydrocarbons, many of which have mutagenic and carcinogenic effects. Pneumoconiosis, fibrosis, asbestosis, silicosis, emphysema, loss of lung function and cancer are some examples of coal-related disorders. The aim of this study was to analyze coal miners with respect to telomere length (TL) and percentage (%) of global DNA methylation. Read More

View Article
December 2018
5 Reads

Bone marrow mesenchymal stromal cells attenuate silica-induced pulmonary fibrosis potentially by attenuating Wnt/β-catenin signaling in rats.

Stem Cell Res Ther 2018 Nov 14;9(1):311. Epub 2018 Nov 14.

Department of Toxicology, Shandong Academy of Occupational Health and Occupational Medicine, Shandong Academy of Medical Sciences, No 18877 Jingshi Road, Lixia District Jinan, Jinan, 250062, Shandong, People's Republic of China.

Background: Pulmonary fibrosis induced by silica dust is an irreversible, chronic, and fibroproliferative lung disease with no effective treatment at present. Previous studies have shown that early intervention with bone marrow mesenchymal stem/stromal cells (BMSCs) has positive effect on anti-pulmonary fibrosis caused by silica dust. However, early intervention using BMSCs is not practical, and the therapeutic effects of BMSCs advanced intervention on pulmonary fibrosis have rarely been reported. Read More

View Article
November 2018
1 Read

Inflammatory and oxidative stress biomarkers at protein and molecular levels in workers occupationally exposed to crystalline silica.

Environ Sci Pollut Res Int 2018 Nov 13. Epub 2018 Nov 13.

Laboratório de Toxicologia (LATOX), Departamento de Análises, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul (UFRGS), Avenida Ipiranga 2752, Santa Cecília, Porto Alegre, RS, 90610-000, Brazil.

Workers chronically exposed to respirable crystalline silica (CS) are susceptible to adverse health effects like silicosis and lung cancer. This study aimed to investigate potential early peripheral biomarkers of inflammation and oxidative stress in miners. The subjects enrolled in this study were occupationally unexposed workers (OUW, n = 29) and workers exposed to crystalline silica (WECS), composed by miners, which were divided into two subgroups: workers without silicosis (WECS I, n = 39) and workers diagnosed with silicosis, retired from work (WECS II, n = 42). Read More

View Article
November 2018
2 Reads

[The spatial distribution and epidemic trend of silicosis in Guangdong province].

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2018 Sep;36(9):662-666

Guangdong Province Hospital for Occupational Disease Prevention and Treatment, Guangzhou 510030, China.

To investigate the characteristics, temporal trend of silicosis, and provide basis for risk assessment and precise prevention and control of occupational diseases. Using descriptive statistics to analyze the reported cases of silicosis by SPSS 20.0 software. Read More

View Article
September 2018
2 Reads

Epidemiology of silicosis: reports from the SWORD scheme in the UK from 1996 to 2017.

Occup Environ Med 2018 Nov 10. Epub 2018 Nov 10.

Centre for Occupational and Environmental Health, University of Manchester, Manchester, UK.

Objective: To document the demographic risk factors of workers reported to have silicosis in the UK.

Methods: All cases of silicosis reported to the Surveillance of Work-related and Occupational Respiratory Disease (SWORD) scheme between January 1996 and December 2017 were classified into one of eight industry categories, and one of five age groups. In addition, to investigate whether there had been any temporal change, mean age and range at diagnosis was plotted for each year. Read More

View Article
November 2018
12 Reads

Monsanto, PCBs, and the creation of a "world-wide ecological problem".

J Public Health Policy 2018 Nov;39(4):463-540

Mailman School of Public Health, Center for the History & Ethics of Public Health, Columbia University, 722 West 168th Street Room 935, New York, NY, 10032, USA.

For the past three decades, we have written on the history of occupational and environmental health, authoring books and articles on lead poisoning, silicosis, asbestosis, and angiosarcoma of the liver, among other diseases. One book, Deceit and Denial, focused specifically on the chemical and lead industries. Because of the rarity of historians who study this history, we have been asked to testify on behalf of workers who allege harm from these industrial materials and by state, county, and local governments who seek redress for environmental damages and funds to prevent future harm to children. Read More

View Article
November 2018
7 Reads

Pirfenidone inhibits epithelial-mesenchymal transition and pulmonary fibrosis in the rat silicosis model.

Toxicol Lett 2019 Jan 28;300:59-66. Epub 2018 Oct 28.

Shandong Academy of Occupational Health and Occupational Medicine, Shandong Academy of Medical Science, Jinan Shandong 250062, China. Electronic address:

To study the role of pirfenidone in rats exposed to silica dust, we established the rat silicosis model with 50 mg/ml silica by intratracheal instillation. From the first day after silica instillation, rats were given pirfenidone (50, 100 mg/kg/day) and rats were sacrificed at 14 days and 28 days to observe the histopathology of lungs, to analyze the level of TNF-α, IL-1β, IL-6 in lung tissues and to measure the expression of TGF-β1, Smad2/3, vimentin, and E-cadherin in lung tissues. Results showed that pirfenidone (50, 100 mg/kg/day) reduced the silica-induced alveolar inflammation, the damage of alveolar structure and the blue areas of collagen fibers in the lungs of rats. Read More

View Article
January 2019
2 Reads

Inhibition of MARCO ameliorates silica-induced pulmonary fibrosis by regulating epithelial-mesenchymal transition.

Toxicol Lett 2018 Nov 2;301:64-72. Epub 2018 Nov 2.

School of Public Health, Xinxiang Medical University, Xinxiang, 453003, China. Electronic address:

Epithelial-mesenchymal transition (EMT) is linked to fibrosis following exposure to silica. The scavenger receptor, macrophage receptor with collagenous structure (MARCO) plays an important role in silica-induced inflammation, however, the effect of MARCO on silica-induced fibrosis has not been identified. We hypothesized that MARCO would regulate EMT and be involved in the development of silicosis. Read More

View Article
November 2018
4 Reads

.

Occup Environ Med 2018 Nov 1. Epub 2018 Nov 1.

Clinic of Occupational and Environmental Medicine, University Hospitals Leuven, Leuven, Belgium.

View Article
November 2018
1 Read

Assessment of Silicosis Awareness among Stone Mine Workers of Rajasthan State.

Indian J Occup Environ Med 2018 May-Aug;22(2):97-100

Department of Occupational Health, National Institute of Miners' Health, Nagpur, Maharashtra, India.

Background: Silicosis is a known occupational lung disease prevalent among stone mine workers. It is commonly characterized by cough and shortening of breath, and is occasionally associated with tuberculosis and lung carcinogenicity. Silicosis is one of the major occupational disease all over the world and poses detrimental health effects to the workers in developing countries like India. Read More

View Article
October 2018
13 Reads

Erratum: Silicosis in Turkey: Is It an Endless Nightmare?

Authors:

Turk Thorac J 2018 Jul 1;19(3):158. Epub 2018 Jul 1.

View Article
July 2018
6 Reads

Tuberculosis, mining and silica.

Authors:
Rodney I Ehrlich

Occup Environ Med 2018 Nov 8;75(11):763-764. Epub 2018 Oct 8.

View Article
November 2018
6 Reads

Silicosis: A former occupational disease with new occupational exposure scenarios.

Rev Clin Esp 2018 Oct 4. Epub 2018 Oct 4.

Servicio de Neumología, Hospital General Universitario de Alicante, Alicante, España.

Background: Recent studies have shown an increase in the prevalence of silicosis due to the use of artificial quartz aggregates (AQA). The aim of this study was to assess the cases of silicosis in our area reported to the Healthcare Information System for Occupational Epidemiological Surveillance of the Autonomous Community of Valencia to detect new agents of exposure to silica and working conditions that promote its onset.

Material And Method: A descriptive study was conducted of cases of silicosis reported to the Healthcare Information System for Occupational Epidemiological Surveillance of the Autonomous Community of Valencia from January 2009 to September 2016. Read More

View Article
October 2018
2 Reads

Computed tomography findings of arc-welders' pneumoconiosis: Comparison with silicosis.

Eur J Radiol 2018 Oct 24;107:98-104. Epub 2018 Aug 24.

Dept. of Clinical Oncology, Nagasaki University Graduate School of Biomedical Sciences, Japan.

Objective: Arc-welders' pneumoconiosis (AWP) is a less fibrogenic pneumoconiosis with radiographic shadows that can improve after isolation from dusty environments. Therefore, early diagnosis is important. However, the exact role of chest radiograph and computed tomography (CT) for diagnosing AWP is not fully understood. Read More

View Article
October 2018
9 Reads

Association between tumor necrosis factor-α -308 Gauss/A polymorphism and risk of silicosis and coal workers pneumoconiosis in Chinese population.

Inhal Toxicol 2018 Sep 26:1-5. Epub 2018 Sep 26.

a Department of Respiratory Medicine , Shenzhen Luohu People's Hospital, The Third Affiliatied Hospital of Shenzhen University , Shenzhen , Guangdong , China.

Background: Many studies have attempted to clarify the association between TNF-a -308G/A polymorphism and pneumoconiosis, but there has been no definite consensus to date. To further assess the effects of TNF-a -308G/A polymorphism on the risk of pneumoconiosis, a meta-analysis was performed in Chinese population.

Methods: We searched the related literature in PubMed and Chinese databases through June 2018. Read More

View Article
September 2018
1 Read

Preventing tuberculosis among silica dust exposed workers.

Authors:

Occup Environ Med 2018 Nov 25;75(11):765-766. Epub 2018 Sep 25.

View Article
November 2018
8 Reads

4-1BB Signaling Promotes Alveolar Macrophages-Mediated Pro-Fibrotic Responses and Crystalline Silica-Induced Pulmonary Fibrosis in Mice.

Front Immunol 2018 10;9:1848. Epub 2018 Sep 10.

Division of Pneumoconiosis, School of Public Health, China Medical University, Shenyang, China.

Silicosis is caused by exposure to crystalline silica (CS). We have previously shown that blocking 4-1BB signaling attenuated CS-induced inflammation and pulmonary fibrosis. However, the cells that express 4-1BB, which plays a vital role in promoting fibrosis, are still unknown. Read More

View Article
September 2018
4 Reads

Subradiological silicosis.

Am J Ind Med 2018 Nov 21;61(11):877-885. Epub 2018 Sep 21.

National Institute for Occupational Health; and School of Public Health, University of the Witwatersrand, Johannesburg, South Africa.

The purpose of this commentary is to bring the neglected phenomenon of subradiological silicosis and its implications to the attention of readers. We define subradiological silicosis as silicosis detectable on pathological examination of lung tissue but not visible radiologically. For extent of the phenomenon, we draw on a study using a large South African autopsy database of deceased miners and chest radiographs taken in life. Read More

View Article
November 2018
1 Read

Nicorandil ameliorates pulmonary inflammation and fibrosis in a rat model of silicosis.

Int Immunopharmacol 2018 Nov 14;64:289-297. Epub 2018 Sep 14.

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt. Electronic address:

Nicorandil, an antianginal and potassium channel opener agent, has different useful impacts on cardiovascular and respiratory systems. Its effect against silicosis has not been discussed yet, therefore, this is an attempt to decide whether nicorandil can reduce silica-induced lung injury in rats. Silica model was induced by intranasal instillation of silica dust once. Read More

View Article
November 2018
1 Read

Silica Exposure, Silicosis, and the New Occupational Safety and Health Administration Silica Standard. What Pulmonologists Need to Know.

Ann Am Thorac Soc 2018 Dec;15(12):1391-1392

Yale Occupational and Environmental Medicine Program, Department of Medicine, Yale University School of Medicine, New Haven, Connecticut.

View Article
December 2018
3 Reads

A Novel Variant of Desmoplakin Is Potentially Associated with Silicosis Risk.

DNA Cell Biol 2018 Nov 12;37(11):925-931. Epub 2018 Sep 12.

1 School of Public Health, Nantong University , Nantong, China .

Two genome-wide association studies and one sequencing study have coincidently reported significant associations of single nucleotide polymorphisms (SNPs) in the desmoplakin (DSP) gene with the risk of pulmonary fibrosis (mainly idiopathic pulmonary fibrosis). However, these findings have not been well generalized to occupational pulmonary fibrosis (e.g. Read More

View Article
November 2018
7 Reads

The CDR1as/miR-7/TGFBR2 Axis Modulates EMT in Silica-Induced Pulmonary Fibrosis.

Toxicol Sci 2018 Dec;166(2):465-478

Department of Occupational Medicine and Environmental Health, School of Public Health, Nanjing Medical University, Nanjing 211166, China.

Silicosis is one of the typical forms of pneumoconiosis characterized by abnormal proliferation of fibroblasts and deposition of extracellular matrix. Recent findings have shown that microRNAs and circular RNAs (circRNAs) are implicated in many diseases. However, the function of noncoding RNAs in pulmonary fibrosis remain to be elucidated. Read More

View Article
December 2018
8 Reads

iTRAQ-based secretome reveals that SiO induces the polarization of RAW264.7 macrophages by activation of the NOD-RIP2-NF-κB signaling pathway.

Environ Toxicol Pharmacol 2018 Oct 17;63:92-102. Epub 2018 Aug 17.

Logistics University of Chinese People's Armed Police Forces, Tianjin 300162, China. Electronic address:

Silicosis is characterized by inflammation and pulmonary fibrosis due to long-term inhalation of crystalline silica (SiO). To clarify the role of macrophage polarization in the inflammatory response of silicosis, we used iTRAQ-coupled 2D LC-MS/MS to study the change in the secretome in RAW264.7 macrophages. Read More

View Article
October 2018
1 Read
1.862 Impact Factor

The Burden of Silicosis in Michigan: 1988-2016.

Ann Am Thorac Soc 2018 Dec;15(12):1404-1410

1 Division of Occupational and Environmental Medicine and.

Rationale: Exposure to respirable crystalline silica causes silicosis, a preventable, progressive occupational lung disease. A more rigorous occupational health standard for silica could help protect silica-exposed workers.

Objectives: To describe trends over 29 years of silicosis surveillance in Michigan. Read More

View Article
December 2018
14 Reads

The 6-Minute Walk Test as a Tool for Determining Exercise Capacity and Prognosis in Patients with Silicosis.

Arch Bronconeumol 2018 Aug 9. Epub 2018 Aug 9.

Servicio de Neumoloxía, Complexo Hospitalario Universitario de Santiago de Compostela, Spanish Biomedical Research Networking Centre-CIBERES, Santiago de Compostela, La Coruña, España.

Objective: To evaluate exercise capacity using the 6-minute walk test (6MWT) in patients with complicated silicosis, and to determine how results shape the prognostic value of 6MWT for hospitalization and mortality.

Method: Prospective observational study in 143 patients with complicated silicosis who performed the 6MWT in our outpatient pulmonology clinic between 2009 and the end of 2016. Lung function tests, computed tomography findings and 6MWT parameters (distance walked and oxygen desaturation) were evaluated. Read More

View Article
August 2018
3 Reads

MicroRNA-29b inhibits supernatants from silica-treated macrophages from inducing extracellular matrix synthesis in lung fibroblasts.

Toxicol Res (Camb) 2017 Nov 24;6(6):878-888. Epub 2017 Aug 24.

School of Public Health , Capital Medical University , Beijing 100069 , China . Email: ; Email: ; ; Tel: +86 10 83911506.

Silicosis is pathologically characterized by diffused pulmonary fibrosis and abundant deposition of extracellular matrix (ECM) components. The ECM is mainly secreted by myofibroblasts which are the activated state of fibroblasts. MicroRNA-29b (miR-29b) is one of the well-known microRNAs involved in fibrosis, but its roles in silicosis have not been specified. Read More

View Article
November 2017
2 Reads

Regulatory role of heme oxygenase-1 in silica-induced lung injury.

Respir Res 2018 08 1;19(1):144. Epub 2018 Aug 1.

Department of Pulmonology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa, 2360004, Japan.

Background: Silicosis, a progressive inflammatory lung disease attributed mainly to occupational exposure to silica dust, shows loss of lung function even after cessation of exposure. In addition to conventional evaluation methods such as chest X-ray, computed tomography, and spirometry, we identified heme oxygenase (HO)-1, an inducible antioxidant, as a potential biomarker to identify at-risk patients. We found that HO-1 was critical in attenuating the disease progression of silicosis; however, the key signaling pathway has not yet been elucidated. Read More

View Article
August 2018
10 Reads

A case of accelerated silicosis.

Occup Med (Lond) 2018 Sep;68(7):482-484

Department of Clinical and Molecular Pathology, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacký University Olomouc, Olomouc, Czech Republic.

Silicosis, caused by inhaling dust containing free crystalline silica, typically has a chronic course, with the numbers of silicosis patients declining globally. Much rarer are the acute and subacute forms. Presented is a case of severe subacute (accelerated) silicosis. Read More

View Article
September 2018

Silica - A trace geogenic element with emerging nephrotoxic potential.

Sci Total Environ 2018 Dec 17;645:297-317. Epub 2018 Jul 17.

Department of Biological Sciences, BITS Pilani, K K Birla Goa Campus, NH 17 B, Zuarinagar, Goa 403 726, India. Electronic address:

Silica is a trace-geogenic compound with limited-bioavailability. It inflicts health-perils like pulmonary-silicosis and chronic kidney disease (CKD), when available via anthropogenic-disturbances. Amidst silica-imposed pathologies, pulmonary toxicological-mechanisms are well-described, ignoring the renal-pathophysiological mechanisms. Read More

View Article
December 2018
12 Reads

A case of Caplan syndrome in a recently diagnosed patient with silicosis: A case report.

Radiol Case Rep 2018 Jun 11;13(3):663-666. Epub 2018 Apr 11.

Department of Rheumatology, Farhat Hached Hospital, Faculty of Medicine of Sousse, Ibn el Jazzar Street, 4000, Sousse, Tunisia.

Rheumatoid pneumoconiosis, also known as Caplan's syndrome is defined as the association between silicosis and rheumatoid arthritis (RA). It is a rare and usually diagnosed in an advanced stage of RA course. It affects generally patients with long exposure to silica. Read More

View Article
June 2018
1 Read

Retrospective Assessment of Respirable Quartz Exposure for a Silicosis Study of the Industrial Sand Industry.

Ann Work Expo Health 2018 Oct;62(8):1021-1032

West Virginia University, School of Medicine, Section of Pulmonary and Critical Care, Morgantown, WV, USA.

Background: In 2016, the OSHA PEL for crystalline silica was reduced, renewing interest in evaluating risk of silicosis from occupational exposures. The industrial sand industry, which deals with high-purity quartz sands, is the setting for a current epidemiologic investigation of silicosis risk and progression. In support of that investigation, respirable quartz (RQ) exposures were retrospectively estimated for 67 workers with silicosis and 167 matched control workers from 21 industrial sand plants, in which some started work as early as 1929. Read More

View Article
October 2018
6 Reads

Occupational emphysema in South African miners at autopsy; 1975-2014.

Int Arch Occup Environ Health 2018 Nov 16;91(8):981-990. Epub 2018 Jul 16.

National Institute of Occupational Health, Johannesburg, South Africa.

Purpose: To determine the associations between exposure duration, measured by employment tenure, and emphysema presence and severity in black and white South African miners at autopsy.

Methods: We examined the association between mining tenure and emphysema presence or severity using the Pathology Automation (PATHAUT) database, 1975-2014. We used logistic regression models adjusted for age, tuberculosis, HIV status, and year of death. Read More

View Article
November 2018
10 Reads

Regulation of TLR4 in silica-induced inflammation: An underlying mechanism of silicosis.

Int J Med Sci 2018 14;15(10):986-991. Epub 2018 Jun 14.

Nethersole School of Nursing, The Chinese University of Hong Kong, Shatin, Hong Kong.

Silicosis is an incurable lung disease affecting millions of workers in hazardous occupations. It is caused by chronic exposure to the dust that contains free crystalline silica. Silica-induced lung damage occurs by several main mechanisms including cell death by apoptosis, fibrosis and production of cytokines. Read More

View Article
June 2018
5 Reads

Silicosis in Switzerland.

Int J Occup Med Environ Health 2018 Oct 16;31(5):659-676. Epub 2018 Jul 16.

Suva, Lucerne, Switzerland (Division of Occupational Medicine).

Objectives: The correlation between quartz dust concentrations in the Swiss enterprises and the incidence of silicosis and other related diseases acknowledged as occupational diseases (OD) was investigated.

Material And Methods: Quartz dust concentrations were obtained from Suva's databases of occupational health surveillance measurements between 2005 and 2014. Information on quartz dust-related diseases was from medical dossiers of workers with OD acknowledged by Suva between 2005 and 2014. Read More

View Article
October 2018
1 Read

Precarious transition: a mortality study of South African ex-miners.

BMC Public Health 2018 Jul 11;18(1):862. Epub 2018 Jul 11.

Centre for Environmental and Occupational Health Research, School of Public Health and Family Medicine, University of Cape Town, Observatory 7925, Cape Town, South Africa.

Background: Despite their burden of a triple epidemic of silicosis, tuberculosis and HIV infection, little is known about the mortality experience of miners from the South African mining industry once they leave employment. Such information is important because of the size and dispersion of this population across a number of countries and the progressive nature of these diseases.

Methods: This study included 306,297 South African miners who left the industry during 2001-2013. Read More

View Article
July 2018
27 Reads

[Results analysis of occupational physical examination for silica dust, benzene and noise-exposed laborer in 2016 in Guangzhou City].

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2018 May;36(5):356-358

Guangzhou Prevention and Treatment Center for Occupational Diseases, Guangzhou 510620, China.

To analyze the results of occupational physical examination for silica dust, benzene and noise-exposed laborer in 2016 in Guangzhou, to provide basis for occupational health supervise. The data were derived from "occupational disease and health information surveillance system" and the summary data reported by all the occupational physical examination agencies, and analyzed by descriptive epidemiology method. 77506 data from 21 agencies of 12 district were collected, and 63 suspected occupational disease were detected, which including 1 silicosis, 8 benzene poisoning, 54 noise deafness. Read More

View Article
May 2018
2 Reads