8,699 results match your criteria Silicosis


Imaging flow cytometry methods for quantitative analysis of label-free crystalline silica particle interactions with immune cells.

AIMS Biophys 2020 26;7(3):144-166. Epub 2020 May 26.

Biomineral Research Group, Department of Veterinary Medicine, University of Cambridge, Madingley Rd, Cambridge CB3 0ES, UK.

Exposure to respirable fractions of crystalline silica quartz dust particles is associated with silicosis, cancer and the development of autoimmune conditions. Early cellular interactions are not well understood, partly due to a lack of suitable technological methods. Improved techniques are needed to better quantify and study high-level respirable crystalline silica exposure in human populations. Read More

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http://dx.doi.org/10.3934/biophy.2020012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7343534PMC

IgG4-Related Disease Complicated by Brain Parenchymal Lesions Successfully Treated with Corticosteroid Therapy: A Case Report.

Tohoku J Exp Med 2020 07;251(3):161-168

Department of Rheumatology, Fukushima Medical University School of Medicine.

Immunoglobulin G4 (IgG4)-related disease (IgG4-RD) is distinguished by the infiltration of IgG4-positive plasma cells in a variety of tissues and organs including the pancreas, salivary glands, retroperitoneal lesions, kidney, and lymph nodes with elevated serum IgG4 levels. Even so, central nervous system (CNS) lesions such as brain parenchymal lesions associated with IgG4-RD are scarce. So far, only six cases of IgG4-RD in relation with brain parenchymal lesions have been described, with its characteristics still being not clear. Read More

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http://dx.doi.org/10.1620/tjem.251.161DOI Listing

[Analysis of new pneumoconiosis in Yantai from 2010 to 2019].

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2020 Jun;38(6):427-430

Department of Occupational Diseases, Yantaishan Hospital, Yantai 264000, China.

To analyze the characteristics of new cases of pneumoconiosis in Yantai from 2010 to 2019, and to provide scientific basis for the prevention and control of pneumoconiosis. In March 2020, 2575 new pneumoconiosis cases in Yantai City from January 1, 2010 to December 31, 2019 were obtained through the "Health Hazard Information Monitoring System" platform under "China Disease Prevention and Control Information System" and patient hospital files. Excel 2007 was used to sort out the database of pneumoconiosis and analyze the epidemiological characteristics of new pneumoconiosis, including gender, age, length of service, type of work, etc. Read More

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http://dx.doi.org/10.3760/cma.j.cn121094-20190909-00371DOI Listing

Relations between vital capacity, CO diffusion capacity and computed tomographic findings of former asbestos-exposed patients: a cross-sectional study.

J Occup Med Toxicol 2020 1;15:21. Epub 2020 Jul 1.

Institute for Occupational and Maritime Medicine (ZfAM), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.

Background: Asbestos-related lung diseases are one of the leading diagnoses of the recognized occupational diseases in Germany, both in terms of their number and their socio-economic costs. The aim of this study was to determine whether pulmonary function testing (spirometry and CO diffusion measurement (D)) and computed tomography of the thorax (TCT) are relevant for the early detection of asbestos-related pleural and pulmonary fibrosis and the assessment of the functional deficiency.

Methods: The records of 111 formerly asbestos-exposed workers who had been examined at the Institute for Occupational and Maritime Medicine, Hamburg, Germany, with data on spirometry, D and TCT were reviewed. Read More

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http://dx.doi.org/10.1186/s12995-020-00272-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328276PMC

Intranasal Flunisolide Suppresses Pathological Alterations Caused by Silica Particles in the Lungs of Mice.

Front Endocrinol (Lausanne) 2020 17;11:388. Epub 2020 Jun 17.

Laboratory of Inflammation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.

Silicosis is an occupational disease triggered by the inhalation of fine particles of crystalline silica and characterized by inflammation and scarring in the form of nodular lesions in the lungs. In spite of the therapeutic arsenal currently available, there is no specific treatment for the disease. Flunisolide is a potent corticosteroid shown to be effective for controlling chronic lung inflammatory diseases. Read More

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http://dx.doi.org/10.3389/fendo.2020.00388DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311565PMC

Severe silicosis due to diatomaceous earth in dental alginate: a necropsy study.

Med Lav 2020 Jun 26;111(3):222-231. Epub 2020 Jun 26.

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Background: Severe silicosis from occupational exposure to calcined diatomaceous earth has been observed in the past, due to the high-temperature transformation of amorphous silica in crystalline phases, mainly cristobalite. In dental alginate production and use a silica exposure may be underestimated.

Objectives: To describe the clinical picture, the scenario and pattern of occupational exposure to silica and the corresponding necroscopic findings of a case of silicosis in a worker engaged in the production of alginates for dental use. Read More

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http://dx.doi.org/10.23749/mdl.v111i3.9742DOI Listing

A novel pathophysiological classification of silicosis models provides some new insights into the progression of the disease.

Ecotoxicol Environ Saf 2020 Jul 1;202:110834. Epub 2020 Jul 1.

State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Department of Pathophysiology, Peking Union Medical College, Beijing, China; Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China; National Clinical Research Center for Respiratory Diseases, Beijing, China. Electronic address:

Silicosis is caused by massive inhalation of silica-based particles, which leads to pulmonary inflammation, pulmonary fibrosis and lung dysfunction. Currently, the pathophysiological process of silicosis has not been well studied. Here, we defined the progression of silicosis as four stages by unsupervised clustering analysis: normal stage, inflammatory stage, progressive stage and fibrotic stage. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2020.110834DOI Listing

Trehalose alleviates apoptosis by protecting the autophagy-lysosomal system in alveolar macrophages during human silicosis.

Life Sci 2020 Jul 2;257:118043. Epub 2020 Jul 2.

School of Medicine, Hunan Normal University, Changsha, Hunan Province 410013, PR China. Electronic address:

Background: Alveolar macrophages (AMs) are the primary targets of silicosis. Blockade of autophagy may aggravate the apoptosis of AMs. Trehalose (Tre), a transcription factor EB (TFEB) activator, may impact the autophagy-lysosomal system in AMs during silicosis. Read More

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http://dx.doi.org/10.1016/j.lfs.2020.118043DOI Listing

Construction of a hybrid lung model by combining a real geometry of the upper airways and an idealized geometry of the lower airways.

Comput Methods Programs Biomed 2020 Jun 20;196:105613. Epub 2020 Jun 20.

Facultad de Enfermería, Universidad de Oviedo, Instituto Nacional de Silicosis and GRUBIPU-ISPA, Spain. Electronic address:

Background And Objective: Health care costs represent a substantial an increasing percentage of global expenditures. One key component is treatment of respiratory diseases, which account for one in twelve deaths in Europe. Computational simulations of lung airflow have potential to provide considerable cost reduction and improved outcomes. Read More

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http://dx.doi.org/10.1016/j.cmpb.2020.105613DOI Listing

Cytotoxicity of fractured quartz on THP-1 human macrophages: role of the membranolytic activity of quartz and phagolysosome destabilization.

Arch Toxicol 2020 Jun 26. Epub 2020 Jun 26.

"G. Scansetti" Interdepartmental Center for Studies On Asbestos and Other Toxic Particulates, Department of Chemistry, University of Torino, Via P. Giuria 7, 10125, Turin, Italy.

The pathogenicity of quartz involves lysosomal alteration in alveolar macrophages. This event triggers the inflammatory cascade that may lead to quartz-induced silicosis and eventually lung cancer. Experiments with synthetic quartz crystals recently showed that quartz dust is cytotoxic only when the atomic order of the crystal surfaces is upset by fracturing. Read More

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http://dx.doi.org/10.1007/s00204-020-02819-xDOI Listing

Characterization of Silica Exposure during Manufacturing of Artificial Stone Countertops.

Int J Environ Res Public Health 2020 Jun 22;17(12). Epub 2020 Jun 22.

Department of Health, West Chester University of Pennsylvania, West Chester, PA 19383, USA.

Artificial stone is increasing in popularity in construction applications, including commercial and residential countertops. Eco-friendliness, durability, and resistance to staining, make artificial stone attractive to consumers. Health concerns have arisen during manufacturing of artificial stone due to increased incidence of silicosis after relatively short exposure. Read More

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http://dx.doi.org/10.3390/ijerph17124489DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7345731PMC

Pulmonary function and high-resolution computed tomography in outdoor rock drillers exposed to crystalline silica.

Occup Environ Med 2020 Jun 22. Epub 2020 Jun 22.

Department of Chemical and Biological Work Environment, National Institute of Occupational Health, Oslo, Norway.

Objectives: Chronic obstructive pulmonary disease and silicosis are associated with exposure to crystalline silica. We determined the exposure to respirable crystalline silica and estimated exposure-response relationships between cumulative exposure and pulmonary function in outdoor rock drillers.

Methods: 136 rock drillers and 48 referents were recruited from three heavy construction companies. Read More

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http://dx.doi.org/10.1136/oemed-2019-106254DOI Listing

Artificial Stone Silicosis: Removal From Exposure Is Not Enough.

Chest 2020 Jun 12. Epub 2020 Jun 12.

University of Illinois at Chicago School of Public Health, Chicago, IL.

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http://dx.doi.org/10.1016/j.chest.2019.11.029DOI Listing

Artificial Stone Silicosis: Rapid Progression Following Exposure Cessation.

Chest 2020 Jun 2. Epub 2020 Jun 2.

Public Health Service, Regional Directorate of the Department of Health and Families of Andalusia in Cádiz, Cádiz, Spain.

Background: Silicosis is rapidly emerging in high-income countries in relation to the replacement of natural stone with artificial stone, especially in the manufacturing and installation of kitchen and bathroom countertops. Progression of this form of silicosis following the cessation of exposure is unknown.

Research Question: The objective of this study was to determine the radiologic progression and lung function in individuals with artificial stone silicosis. Read More

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http://dx.doi.org/10.1016/j.chest.2020.03.026DOI Listing

Efficacy and safety of weekly rifapentine and isoniazid for tuberculosis prevention in Chinese silicosis patients: a randomized controlled trial.

Clin Microbiol Infect 2020 Jun 15. Epub 2020 Jun 15.

Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai 200040, China; National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China; Key Laboratory of Medical Molecular Virology (MOE/MOH) and Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China; State Key Laboratory of Genetic Engineering, School of Life Science, Fudan University, Shanghai 200438, China. Electronic address:

Objectives: To evaluate the efficacy, safety and completion rate of three-month, once-weekly rifapentine and isoniazid for tuberculosis (TB) prevention among Chinese silicosis patients.

Methods: Male silicosis patients without human immunodeficiency virus infection, aged 18 years to 65 years, with or without latent TB infection, were randomized 1:1 to receive rifapentine/isoniazid under direct observation (3RPT/INH group) or were untreated (observation group). Active TB incidence was compared between the two groups with 37 months follow-up. Read More

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http://dx.doi.org/10.1016/j.cmi.2020.06.008DOI Listing
June 2020
5.768 Impact Factor

Magnetic targeting increases mesenchymal stromal cell retention in lungs and enhances beneficial effects on pulmonary damage in experimental silicosis.

Stem Cells Transl Med 2020 Jun 15. Epub 2020 Jun 15.

Laboratory of Pulmonary Investigation, Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil.

Silicosis is a pneumoconiosis caused by inhaled crystalline silica microparticles, which trigger inflammatory responses and granuloma formation in pulmonary parenchyma, thus affecting lung function. Although systemic administration of mesenchymal stromal cells (MSCs) ameliorates lung inflammation and attenuates fibrosis in experimental silicosis, it does not reverse collagen deposition and granuloma formation. In an attempt to improve the beneficial effects of MSCs, magnetic targeting (MT) has arisen as a potential means of prolonging MSC retention in the lungs. Read More

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http://dx.doi.org/10.1002/sctm.20-0004DOI Listing

Trends in Pneumoconiosis Deaths - United States, 1999-2018.

MMWR Morb Mortal Wkly Rep 2020 Jun 12;69(23):693-698. Epub 2020 Jun 12.

Pneumoconioses are preventable occupational lung diseases caused by inhaling dust particles such as coal dust or different types of mineral dusts (1). To assess recent trends in deaths associated with pneumoconiosis, CDC analyzed multiple cause-of-death data* for decedents aged ≥15 years for the years 1999-2018, and industry and occupation data collected from 26 states for the years 1999, 2003, 2004, and 2007-2013. During 1999-2018, pneumoconiosis deaths decreased by 40. Read More

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http://dx.doi.org/10.15585/mmwr.mm6923a1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315788PMC

Bacterial pathogens from lower respiratory tract infections: A study from Western Rajasthan.

J Family Med Prim Care 2020 Mar 26;9(3):1407-1412. Epub 2020 Mar 26.

Department of Microbiology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.

Respiratory tract infections are the most common diseases that are associated with social burden for the patient. Western Rajasthan has cases of Cystic fibrosis due to migrant population. The dry and dusty environment has led to prevalence of silicosis and COPD. Read More

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http://dx.doi.org/10.4103/jfmpc.jfmpc_994_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7266181PMC

Prevalence and Clinical Impact of Systemic Autoimmune Rheumatic Disease in Patients with Silicosis.

Arch Bronconeumol 2020 May 31. Epub 2020 May 31.

Servicio de Neumoloxía. Complexo Hospitalario Universitario de Santiago de Compostela; Spanish Biomedical Research Networking Centre-CIBERES, A Coruña, España.

Background: Silicosis is associated with an increased risk of developing systemic autoimmune rheumatic disease (SARD). The prognostic implications of this association are poorly characterized. The aim of this study was to determine the prevalence of SARD and autoimmune markers in a cohort of patients with exposure to silica and assess their impact on prognosis. Read More

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http://dx.doi.org/10.1016/j.arbres.2020.04.012DOI Listing

Predictors of silicosis and variation in prevalence across mines among employed gold miners in South Africa.

BMC Public Health 2020 Jun 1;20(1):829. Epub 2020 Jun 1.

School of Public Health, University of the Witwatersrand, Johannesburg, South Africa.

Background: The stated intention to eliminate silicosis from the South African goldmining industry as well as current programmes to find and compensate ex-miners with silicosis require an understanding of variation in silicosis prevalence across the industry. We aimed to identify the predictors of radiological silicosis in a large sample of working miners across gold mines in South Africa.

Methods: Routine surveillance chest radiographs were collected from 15 goldmine "clusters" in a baseline survey undertaken in preparation for a separate tuberculosis isoniazid prophylaxis trial. Read More

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http://dx.doi.org/10.1186/s12889-020-08876-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268682PMC

Pulmonary Silicosis Alters MicroRNA Expression in Rat Lung and miR-411-3p Exerts Anti-fibrotic Effects by Inhibiting MRTF-A/SRF Signaling.

Mol Ther Nucleic Acids 2020 Jun 12;20:851-865. Epub 2020 May 12.

School of Public Health, North China University of Science and Technology, Tangshan, 063210 Hebei, China. Electronic address:

To identify potential therapeutic targets for pulmonary fibrosis induced by silica, we studied the effects of this disease on the expression of microRNAs (miRNAs) in the lung. Rattus norvegicus pulmonary silicosis models were used in conjunction with high-throughput screening of lung specimens to compare the expression of miRNAs in control and pulmonary silicosis tissues. A total of 70 miRNAs were found to be differentially expressed between control and pulmonary silicosis tissues. Read More

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http://dx.doi.org/10.1016/j.omtn.2020.05.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256439PMC

Club cell protein 16 as a biomarker for early detection of silicosis.

Indian J Med Res 2020 04;151(4):319-325

ICMR-National Institute of Occupational Health, Ahmedabad, Gujarat, India.

Background & Objectives: Clinically silicosis is diagnosed by chest X-ray showing specific opacities along with history of silica dust exposure. Diagnosis is invariably made at an advanced or end stage when it is irreversible. Moreover, silicosis patients are susceptible to develop tuberculosis. Read More

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http://dx.doi.org/10.4103/ijmr.IJMR_1799_18DOI Listing

[Progress in study on intervention of silica-induced pulmonary fibrosis with the exosomes released from mesenchymal stem cells].

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2020 Apr;38(4):309-313

National Center for Occupational Safety and Health, National Health Commission of the People's Republic of China, Beijing 102308, China.

Pneumoconiosis is an occupational disease which seriously endangers the health of workers exposed to dust. Silica is regarded as the most serious cause of pneumoconiosis because it can cause diffuse pulmonary fibrosis in workers' lung tissue. Mesenchymal stem cells (MSCs) are adult stem cells with multiple differentiation potential. Read More

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http://dx.doi.org/10.3760/cma.j.cn121094-20190709-00275DOI Listing

[Follow-up and retrospective investigation of patients with pneumoconiosis in Jiangsu Province, China].

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2020 Apr;38(4):251-255

Jiangsu Province Center for Disease Control and Prevention, Nanjing 210028, China.

To investigate the features, changing trend, and rules of pneumoconiosis in Jiangsu Province, China, as well as the health status of patients with pneumoconiosis. From July to October 2019, the patients with pneumoconiosis, reported up to the end of 2018 in Jiangsu Province, were enrolled as respondents, and follow-up and retrospective investigation were performed. A total of 24405 patients with pneumoconiosis were investigated, and related data were collected from the monitoring system of cause of death for residents, pneumoconiosis network reporting system, occupational disease diagnosis institution, management institutions for the reporting of occupational diseases, and related residents' committee or village committee. Read More

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http://dx.doi.org/10.3760/cma.j.cn121094-20191115-00530DOI Listing

Chylothorax in a Case of Accelerated Silicosis with Pulmonary Silicoproteinosis: A Unique Association.

Indian J Occup Environ Med 2020 Jan-Apr;24(1):39-41. Epub 2020 Mar 18.

Department of Medicine, All India Institute of Medical Sciences, New Delhi, India.

A 32-year-old gentleman, a worker in a cement-manufacturing facility with suspected silica-induced lung disease presented with acutely worsening Type 1 respiratory failure. With a negative work-up for infectious causes and no further revelations on bronchoalveolar lavage fluid or endobronchial biopsy, it was a transbronchial biopsy that ultimately led us to a diagnosis of silicoproteinosis with accelerated silicosis. Interestingly, the patient had a pleural effusion which on thoracentesis showed chylous fluid-the first reported case of chylothorax in association with silicosis. Read More

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http://dx.doi.org/10.4103/ijoem.IJOEM_63_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227742PMC

High-mobility group box 1 promotes epithelial-to-mesenchymal transition in crystalline silica induced pulmonary inflammation and fibrosis.

Toxicol Lett 2020 May 17;330:134-143. Epub 2020 May 17.

Department of Occupational & Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China. Electronic address:

Silicosis is an inflammatory and fibrotic lung disease caused by prolonged inhalation of silica. The potential role of high-mobility group box-1 (HMGB-1) and its underlying mechanisms in silicosis remain unclear. In this study, intratracheal instillation of a silica suspension was used to establish silicosis in male C57BL/6 mice. Read More

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http://dx.doi.org/10.1016/j.toxlet.2020.05.016DOI Listing

PRKCSH Alternative Splicing Involves in Silica-Induced Expression of Epithelial-Mesenchymal Transition Markers and Cell Proliferation.

Dose Response 2020 Apr-Jun;18(2):1559325820923825. Epub 2020 May 8.

Department of Radiation Biology, Beijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine, AMMS, Beijing, China.

Background: Mounting evidence suggests that alternative splicing is one of the ways for cells to adapt to environmental stress insults. The aim of this study was firstly to examine the effect of silica on the alternative splicing of lung fibrosis-associated genes.

Methods: Microarray analysis was used to construct the alternative splicing profile. Read More

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http://dx.doi.org/10.1177/1559325820923825DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218327PMC

Lung function and functional exercise capacity in underground semi-precious stone mineworkers.

Work 2020 ;66(1):193-200

Programa de Pós-Graduação em Ciências Pneumológicas, Universidade Federal do Rio Grande do Sul, RS, Brasil.

Background: Semi-precious stone mining may cause occupational lung disease. The impact of inhaling silica on workers' exercise capacity has only been partially studied.

Objectives: To study lung function, exercise capacity, and identify factors associated with functional impairment. Read More

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http://dx.doi.org/10.3233/WOR-203163DOI Listing
January 2020

A suitable biomarker of effect, club cell protein 16, from crystalline silica exposure among Thai stone-carving workers.

Toxicol Ind Health 2020 Apr 12;36(4):287-296. Epub 2020 May 12.

Department of Forensic Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.

Exposure to respirable crystalline silica (RCS) reportedly induces chronic lung injury. We investigated the association between RCS exposure and two biomarkers of the effect, plasma club cell protein 16 (CC16) and heme oxygenase-1 (HO-1) levels, in stone-carving workers. Fifty-seven exposed workers (EWs) and 20 unexposed workers (UWs) were enrolled onto the study. Read More

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http://dx.doi.org/10.1177/0748233720920137DOI Listing

ACE2 Attenuates Epithelial-Mesenchymal Transition in MLE-12 Cells Induced by Silica.

Drug Des Devel Ther 2020 21;14:1547-1559. Epub 2020 Apr 21.

School of Public Health, North China University of Science and Technology, Tangshan, Hebei 063210, People's Republic of China.

Purpose: The role of angiotensin-converting enzyme 2 (ACE2) in silicosis remains unknown, although previous studies have suggested that ACE2 may be beneficial. We, therefore, investigated the effect of ACE2 on silicosis, particularly with regard to its role in regulating the epithelial-mesenchymal transition (EMT) induced by silica, with the aim to uncover a new potential target for the treatment of pulmonary fibrosis.

Materials And Methods: We employed wild-type mice treated with diminazene aceturate (DIZE, an ACE2 activator, 15 mg/kg/day for 4 weeks), -transgenic mice (overexpress the gene), and the mouse lung type II epithelial cell line treated with DIZE (10 M for 48 h) or angiotensin-(1-7) [Ang-(1-7)] (10 M for 48 h), following induced fibrotic responses to determine the protective potential of ACE2. Read More

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http://dx.doi.org/10.2147/DDDT.S252351DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7183338PMC

Silicosis in finishing workers in quartz conglomerates processing.

Med Lav 2020 Apr 30;111(2):99-106. Epub 2020 Apr 30.

Department of Cardiac-Thoracic-Vascular Sciences and Public Health, University of Padua, Padua, Italy.

Introduction: Outbreaks of silicosis have bene recently reported in artificial stone workers.

Aim: To describe the features of silicosis in quartz conglomerate workers in North-Eastern Italy.

Methods: Active search of pneumoconiosis was performed in 11 companies of North-Eastern Italy involved in the fabrication of quartz conglomerate countertops. Read More

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http://dx.doi.org/10.23749/mdl.v111i2.9115DOI Listing

Decreased Soluble Receptor of Advanced Glycation End Product Levels Correlated with Inflammation in Silicosis.

Mediators Inflamm 2020 14;2020:2683753. Epub 2020 Apr 14.

Hebei Key Laboratory of Organ Fibrosis, School of Public Health, North China University of Science and Technology, Tangshan, Hebei 063210, China.

Silicosis is a devastating disease caused by inhalation of silica dust that leads to inflammatory cascade and then scarring of the lung tissue. Increasing evidences indicate that soluble receptor for advanced glycation end products (sRAGE) is involved in inflammatory diseases. However, no data on the possible relationship between sRAGE and inflammation of silicosis are available. Read More

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http://dx.doi.org/10.1155/2020/2683753DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178542PMC

Respirable Crystalline Silica Exposure, Smoking, and Lung Cancer Subtype Risks: A Pooled Analysis of Case-control Studies.

Am J Respir Crit Care Med 2020 Apr 24. Epub 2020 Apr 24.

University of Utrecht, Institute for Risk Assessment Sciences, Division of Environmental Epidemiology, Utrecht, Netherlands.

Rationale And Objectives: Respirable crystalline silica is a lung carcinogen with millions of exposed workers globally. We aimed to address current knowledge gaps in lung cancer risks associated with low levels of occupational silica exposure and the joint effects of smoking and silica exposure on lung cancer risks.

Methods: Subjects from 14 case-control studies from Europe and Canada with detailed smoking and occupational histories were pooled. Read More

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http://dx.doi.org/10.1164/rccm.201910-1926OCDOI Listing

Can the South African Milestones for Reducing Exposure to Respirable Crystalline Silica and Silicosis be Achieved and Reliably Monitored?

Front Public Health 2020 7;8:107. Epub 2020 Apr 7.

Faculty of Health Sciences, School of Public Health, University of the Witwatersrand, Johannesburg, South Africa.

Silicosis and other respirable crystalline silica-associated diseases, most notably tuberculosis, have long been substantial causes of morbidity and mortality in South Africa. For the mining and non-mining industries, silicosis elimination programmes have been developed with milestones regarding reduction of levels of exposure to respirable crystalline silica (RCS) and targets regarding the date of eradication. The present paper explores the feasibility of achieving these targets by investigating the evidence that levels of exposure and silicosis incidence rates have declined by an appraisal of the methods for data collection and reporting. Read More

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http://dx.doi.org/10.3389/fpubh.2020.00107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7154115PMC

Computer-aided detection for tuberculosis and silicosis in chest radiographs of gold miners of South Africa.

Int J Tuberc Lung Dis 2020 Apr;24(4):444-451

School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada.

For over one hundred years, the gold mining sector has been a considerable source of tuberculosis (TB) and silicosis disease burden across Southern Africa. Reading chest radiographs (CXRs) is an expert and time-intensive process necessary for the screening and diagnosis of lung disease and the provision of evidence for compensation claims. Our study explores the use of computer-aided detection (CAD) of TB and silicosis in CXRs of a population with a high incidence of both diseases. Read More

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http://dx.doi.org/10.5588/ijtld.19.0624DOI Listing

Computer-assisted interpretation of chest radiographs: signs of hope for silicosis and tuberculosis.

Authors:
A S Laney E Pontali

Int J Tuberc Lung Dis 2020 Apr;24(4):362-363

Department of Infectious Diseases, Galliera Hospital, Genoa, Italy.

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http://dx.doi.org/10.5588/ijtld.19.0805DOI Listing

Single Intratracheal Quartz Instillation Induced Chronic Inflammation and Tumourigenesis in Rat Lungs.

Sci Rep 2020 Apr 20;10(1):6647. Epub 2020 Apr 20.

Oncology Pathology, Department of Pathology and Host-Defence, Faculty of Medicine, Kagawa University, Kagawa, 761-0793, Japan.

Crystalline silica (quartz) is known to induce silicosis and cancer in the lungs. In the present study, we investigated the relationship between quartz-induced chronic inflammation and lung carcinogenesis in rat lungs after a single exposure to quartz. F344 rats were treated with a single intratracheal instillation (i. Read More

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http://dx.doi.org/10.1038/s41598-020-63667-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170867PMC

[Diagnostic value of heparin-binding protein in patients with silicosis complicated by severe infection].

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2020 Mar;38(3):207-210

The Second Affiliated Hospital of Xuzhou Medical University, Xuzhou Mining Group General Hospital, Xuzhou 221006, China.

To explore the application value of heparin binding protein (HBP) in the diagnosis of severe infection in patients with silicosis. A prospective study was conducted on 150 patients with silicosis in the pneumoconiosis department of the General Hospital of Xuzhou Mining Group from January 2017 to March 2018. Among them, 100 were severely infected with silicosis and 50 were non-infected with silicosis. Read More

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http://dx.doi.org/10.3760/cma.j.cn121094-20190621-00258DOI Listing

[The characteristics of spatial-temporal evolvement of pneumoconiosis in Hebei Province from 2009 to 2018].

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2020 Mar;38(3):175-179

Department of Epidemiology and Statistics, Hebei Medical University, Shijiazhuang 050017, China; Hebei Province Center for Disease Prevention and Control, Shijiazhuang 050021, China.

To explore the temporal and spatial characteristics of pneumoconiosis in Hebei Province from 2009 to 2018, and to provide evidence for the policy development of pneumoconiosis prevention and control. In February 2019, a database of pneumoconiosis incidence from 2009 to 2018 in Hebei Province was built. The spatial-temporal distribution of pneumoconiosis in Hebei Province was displayed based on barycenter migration technology and spatial autocorrelation analysis. Read More

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http://dx.doi.org/10.3760/cma.j.cn121094-20190507-00182DOI Listing

[The Function of CD40/CD40L Pathway in Silicosis Fibrosis].

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2020 Feb;38(2):96-100

Department of Occupational Disease, Zhejiang Integrated Traditional and Western medicine Hospital, Hangzhou (310003) , China.

To investigate the role of CD40/CD40L Pathway in the formation of silicosis fibrosis. Totally 64 inpatients were recruited and assigned to the silicosis group and the control group, 23 in each group. The alveolar lavage fluid was collected from all patients and isolated. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1001-9391.2020.02.004DOI Listing
February 2020

Comparison of Risk of Silicosis in Metal Mines and Pottery Factories: A 44-Year Cohort Study.

Chest 2020 Apr 13. Epub 2020 Apr 13.

Department of Occupational & Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei. Electronic address:

Background: Little is known about the different risk of silicosis in metal mines and pottery factories. We aimed to compare the silicosis risks among silica-exposed workers in different industrial circumstances.

Research Question: Are the silicosis risks among silica-exposed workers in industrial circumstances different?

Study Design And Methods: We studied 39,808 workers followed up from January 1, 1960 to December 31, 2003 in China. Read More

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http://dx.doi.org/10.1016/j.chest.2020.03.054DOI Listing

Silico-tuberculosis, silicosis and other respiratory morbidities among sandstone mine workers in Rajasthan- a cross-sectional study.

PLoS One 2020 16;15(4):e0230574. Epub 2020 Apr 16.

Department of General Surgery, Chettinad Medical College and Hospital, Chennai, Tamil Nadu, India.

Background: Exposures to respirable crystalline silica causes silicosis, pulmonary tuberculosis, chronic obstructive pulmonary disease, lung cancer, autoimmune disorders and chronic renal disease. The aim of this study was to find out the prevalence of silico-tuberculosis, silicosis and other respiratory morbidities in sandstone mine workers in Jodhpur district of Rajasthan.

Methods: It was a cross-sectional study done in sandstone mines in Jodhpur. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0230574PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7162522PMC
July 2020
3.234 Impact Factor

Familial Interstitial Lung Disease.

Semin Respir Crit Care Med 2020 Apr 12;41(2):229-237. Epub 2020 Apr 12.

Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.

The interstitial lung diseases (ILDs) are a group of progressive disorders characterized by chronic inflammation and/or fibrosis in the lung. While some ILDs can be linked to specific environmental causes (i.e. Read More

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http://dx.doi.org/10.1055/s-0040-1708054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7272214PMC

Estimation of the number of workers exposed to respirable crystalline silica by industry: Analysis of OSHA compliance data (1979-2015).

Am J Ind Med 2020 Jun 9;63(6):465-477. Epub 2020 Apr 9.

Respiratory Health Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia.

Background: Respirable crystalline silica (RCS) can potentially cause silicosis, lung cancer, and renal failure. The current study estimates the percentages of workers potentially overexposed to concentrations of RCS dust and silicosis proportional mortality rates (PMRs) by industry.

Methods: Occupational Safety and Health Administration compliance inspection sampling data for RCS collected during 1979 to 2015 were used to estimate percentages of workers exposed. Read More

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http://dx.doi.org/10.1002/ajim.23109DOI Listing

Performance Comparison of Four Portable FTIR Instruments for Direct-on-Filter Measurement of Respirable Crystalline Silica.

Ann Work Expo Health 2020 Jun;64(5):536-546

Office of Mine Safety and Health Research, Pittsburgh Mining Research Division (PMRD), National Institute for Occupational Safety and Health (NIOSH), Centers for Disease Control and Prevention (CDC), Pittsburgh, PA, USA.

Exposure to dusts containing respirable crystalline silica is a recognized hazard affecting various occupational groups such as miners. Inhalation of respirable crystalline silica can lead to silicosis, which is a potentially fatal lung disease. Currently, miners' exposure to respirable crystalline silica is assessed by collecting filter samples that are sent for laboratory analysis. Read More

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http://dx.doi.org/10.1093/annweh/wxaa031DOI Listing

P2Y Receptor Antagonist Clopidogrel Attenuates Lung Inflammation Triggered by Silica Particles.

Front Pharmacol 2020 18;11:301. Epub 2020 Mar 18.

Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

Silicosis is an occupational lung disease caused by inhalation of silica particles. It is characterized by intense lung inflammation, with progressive and irreversible fibrosis, leading to impaired lung function. Purinergic signaling modulates silica-induced lung inflammation and fibrosis through P2X7 receptor. Read More

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http://dx.doi.org/10.3389/fphar.2020.00301DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093325PMC

In silico prototype of a human lung with a single airway to predict particle deposition.

Int J Numer Method Biomed Eng 2020 Jun 13;36(6):e3339. Epub 2020 Apr 13.

Departamento de Energía, Universidad de Oviedo and GRUBIPU-ISPA, Asturias, Spain.

Background: Experimental analyses of the flow of drug particles inside the human lung usually require that the patient be exposed to radiation and also of expensive equipment that often lack of enough accuracy. Numerical calculations based on CFD (computational fluid dynamics) have been proven to be a valuable tool to analyze flows in diverse applications.

Methods: The complexity of the human lung disallows running calculations on complete lung models due to the large number of cells that would be required. Read More

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http://dx.doi.org/10.1002/cnm.3339DOI Listing

Therapeutic Use of Extracellular Vesicles for Acute and Chronic Lung Disease.

Int J Mol Sci 2020 Mar 27;21(7). Epub 2020 Mar 27.

Division of Pulmonology, Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

Multipotent mesenchymal stem cells (MSCs) possess regenerative properties and have been shown to improve outcomes and survival in acute and chronic lung diseases, but there have been some safety concerns raised related to MSC-based therapy. Subsequent studies have demonstrated that many of the regenerative effects of MSCs can be attributed to the MSC-derived secretome, which contains soluble factors and extracellular vesicles (EVs). MSC-derived extracellular vesicles (MSC-derived EVs) replicate many of the beneficial effects of MSCs and contain a variety of bioactive factors that are transferred to recipient cells, mediating downstream signaling. Read More

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http://dx.doi.org/10.3390/ijms21072318DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7177288PMC

Respiratory Health in a Community Living in Close Proximity to Gold Mine Waste Dumps, Johannesburg, South Africa.

Int J Environ Res Public Health 2020 03 26;17(7). Epub 2020 Mar 26.

Occupational Medicine Section, National Institute for Occupational Health, National Health Laboratory Service, Johannesburg 2001, Gauteng Province, South Africa.

The effects on respiratory health in populations living close to silica-rich gold mine dumps are unknown. This pilot study related respiratory health and exposure to mine dump dust using two measures of exposure: exposure group, based on distance lived from the mine dump-high ( = 93) (home <500 m from a mine dump), moderate ( = 133) (500-1.5 km), and low ( = 84) (>15 km, control group); and cumulative exposure index (CEI) derived from exposure group and number of years of residence in each exposure group. Read More

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http://dx.doi.org/10.3390/ijerph17072240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178068PMC