8,458 results match your criteria Silicosis


Those Who Don't Return: Improving Efforts to Address Tuberculosis Among Former Miners in Southern Africa.

New Solut 2019 Feb 21:1048291119832082. Epub 2019 Feb 21.

2 University of North Carolina at Chapel Hill, NC, USA.

Despite increasing awareness regarding the role of oscillating migration in the mining industry as a major driving force in the spread of tuberculosis (TB) throughout southern Africa, very little work has focused on the historical and contextual factors which may contribute to former migrant miners' present-day risk of TB. Most research regarding migration-related and occupational influences on TB has been done on current miners still employed by the mining industry. Through both a historical and contemporary lens, this paper explores and elucidates the need to address the TB epidemic among former migrant mine workers and provides considerations to improve current interventions among this critical population. Read More

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http://dx.doi.org/10.1177/1048291119832082DOI Listing
February 2019

Carvedilol attenuates experimentally induced silicosis in rats via modulation of P-AKT/mTOR/TGFβ1 signaling.

Int Immunopharmacol 2019 Feb 20;70:47-55. Epub 2019 Feb 20.

Dep. of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt. Electronic address:

Silicosis is a well acknowledged occupational lung disorder with considerable negative impact on the patients' quality of life. Various signaling pathways have been reported to interplay in the pathogenesis of pulmonary fibro-proliferative disorders; of which, P-AKT/mTOR signaling pathway. The current study highlights the potential pulmonary protective effect of carvedilol; a non-selective α/β blocker against experimental silicosis-induced in rats by the intranasal installation of silica (50 mg/rat, 1 ml 0. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.02.011DOI Listing
February 2019

Application of protein chip combined with SELDI-TOF-MS detection to investigate serum protein expression in patients with silicosis fibrosis.

Exp Ther Med 2019 Mar 11;17(3):2172-2184. Epub 2019 Jan 11.

Endocrinology Department, The Fifth Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830011, P.R. China.

The present study aimed to observe the identification of biomarkers of silicosis based on the differentially expressed serum proteins between normal healthy individuals and patients with silicosis fibrosis. A total number of 20 patients with clinically diagnosed silicosis were screened, which were designated as the foundation treatment group. In addition, 20 age-matched healthy patients attending a check-up at the physical examination department were selected. Read More

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http://dx.doi.org/10.3892/etm.2019.7166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364189PMC

Artificial Stone Associated Silicosis: A Systematic Review.

Int J Environ Res Public Health 2019 Feb 16;16(4). Epub 2019 Feb 16.

Section of Occupational Medicine, Department of Public Health, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy.

Silicosis is a progressive fibrotic lung disease that is caused by the inhalation of respirable crystalline silica. Due to its high silica content, artificial stone (AS) can become a possible source of hazardous dust exposure for workers that are employed in the manufacturing, finishing, and installing of AS countertops. Therefore, the aim of this review was to verify the association between AS derived silica exposure and silicosis development, and also then define the pathological characteristics of the disease in relation to specific work practices and preventive and protective measures that were adopted in the workplace. Read More

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http://dx.doi.org/10.3390/ijerph16040568DOI Listing
February 2019

Asbestosis and silicosis hospitalizations in Italy (2001-2015): results from the National Hospital Discharge Registry.

Eur J Public Health 2019 Feb 7. Epub 2019 Feb 7.

Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, Italian National Workers' Compensation Authority (INAIL), Rome, Italy.

Background: This work is aimed at evaluating the quality of Italian hospitalizations data about asbestosis and silicosis, assessing the impact of these diseases on the national health system and providing advice related to public health.

Methods: Italian hospital discharge data (2001-15) with diagnosis of asbestosis or silicosis were analysed by the multiple correspondence analysis and diseases epidemics were evaluated through hospitalization rates.

Results: Hospitalizations were concentrated in the northwestern area, referred mainly to males and oldest people, the most treated tumors were lung cancer and mesothelioma (for asbestosis) and cares were aimed at reducing symptoms and increasing blood oxygenation. Read More

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http://dx.doi.org/10.1093/eurpub/ckz003DOI Listing
February 2019
1 Read

Whole-lung lavage for severe pulmonary alveolar proteinosis assisted by veno-venous extracorporeal membrane oxygenation: a case report.

Can J Respir Ther 2018 Dec 5;55(1). Epub 2018 Dec 5.

Department of Anesthesiology, Centro Hospitalar São João, Porto, Portugal.

Pulmonary alveolar proteinosis (PAP) is a rare pathology characterized by accumulation of phospholipoproteinaceous material within the alveoli. The evolution of PAP is variable and treatment modalities are limited. Pharmacological therapeutic targets are being actively developed, but whole-lung lavage (WLL), first described in the 1960s, remains the cornerstone of therapy. Read More

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http://dx.doi.org/10.29390/cjrt-2018-019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345579PMC
December 2018
6 Reads

Aluminum in the lungs of Ontario hardrock miners.

Authors:
Dave K Verma

Arch Environ Occup Health 2019 Feb 11:1-4. Epub 2019 Feb 11.

a Department of Family Medicine and Program in Occupational Health & Environmental Medicine , McMaster University , Hamilton , ON , Canada.

The objective of this study was to determine the concentration of aluminum in the autopsied lungs of eight hardrock miners. These miners had inhaled McIntyre Powder (a mixture of aluminum and aluminum oxide) as a prophylaxis against silicosis. The study involved chemical analysis of lungs, where each whole lung was divided horizontally into three sections and analyzed by atomic absorption spectrophotometer equipped with a graphite furnace. Read More

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http://dx.doi.org/10.1080/19338244.2019.1574703DOI Listing
February 2019
1 Read

Tuberculosis infection among the elderly in 20,486 rural residents aged 50-70 years old in Zhongmu County, China.

Clin Microbiol Infect 2019 Feb 7. Epub 2019 Feb 7.

NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, and Center for Tuberculosis Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P.R. China, 100730. Electronic address:

Objectives: Elderly in rural China has been known to be at increased risk of contracting tuberculosis (TB) infection and developing active disease. This study aims to estimate the burden of TB infection and to identify potential targeted subgroups for infection control.

Methods: As a part of the investigation of an interventional study, 50-70 years old rural residents in Zhongmu County were targeted for TB infection testing by QuantiFERON-TB Gold In-Tube (QFT). Read More

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http://dx.doi.org/10.1016/j.cmi.2019.01.021DOI Listing
February 2019
1 Read

Characteristics and Trends of Pneumoconiosis in the Jiangsu Province, China, 2006⁻2017.

Int J Environ Res Public Health 2019 Feb 2;16(3). Epub 2019 Feb 2.

Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 211166, China.

This study aims to describe the characteristics and trends of pneumoconiosis in the Jiangsu Province, China, and provide information for the occupational diseases control. We collected and analyzed the data of pneumoconiosis cases reported annually from 2006 to 2017. The information of the cases mainly includes case distributions, clinical types and stages, enterprise types and scales, as well as diagnosis age and exposure duration. Read More

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http://dx.doi.org/10.3390/ijerph16030437DOI Listing
February 2019
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Prevalence of pneumoconiosis among young adults aged 24-44 years in a heavily industrialized province of China.

J Occup Health 2019 Jan;61(1):73-81

Hebei Provincial Center for Disease Control and Prevention, Shijiazhuang, China.

Objectives: The purposes of this study were to clarify (i) the prevalence of pneumoconiosis among young adults and (ii) the factors associated with pneumoconiosis among young adults to explore targeted solution for control of pneumoconiosis among young adults (aged 24-44 years).

Methods: The new cases diagnosed from 2001 to 2015 (extracted from the National Occupational Disease and Occupational Health Information Monitoring System) were involved in this research, including information of employer, patient's name, date of birth, gender, date of diagnosis, first year of dust exposure, duration of exposure, aggregation etc RESULTS: A total of 1519 pneumoconiosis cases were diagnosed among young adults (21.6% of overall cases). Read More

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http://doi.wiley.com/10.1002/1348-9585.12029
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http://dx.doi.org/10.1002/1348-9585.12029DOI Listing
January 2019
4 Reads

Immunity to the Dual Threat of Silica Exposure and .

Front Immunol 2018 9;9:3069. Epub 2019 Jan 9.

Division of Immunology, Department of Pathology and Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.

Exposure to silica and the consequent development of silicosis are well-known health problems in countries with mining and other dust producing industries. Apart from its direct fibrotic effect on lung tissue, chronic and immunomodulatory character of silica causes susceptibility to tuberculosis (TB) leading to a significantly higher TB incidence in silica-exposed populations. The presence of silica particles in the lung and silicosis may facilitate initiation of tuberculous infection and progression to active TB, and exacerbate the course and outcome of TB, including prognosis and survival. Read More

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https://www.frontiersin.org/article/10.3389/fimmu.2018.03069
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http://dx.doi.org/10.3389/fimmu.2018.03069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334662PMC
January 2019
5 Reads

Lipid Uptake by Alveolar Macrophages Drives Fibrotic Responses to Silica Dust.

Sci Rep 2019 Jan 23;9(1):399. Epub 2019 Jan 23.

School of Public Health, North China University of Science and Technology, Tangshan, Hebei, 063210, China.

Silicosis is a common occupational disease and represents a significant contributor to respiratory morbidity and mortality worldwide. Lipid-laden macrophages, or foam cells, are observed in the lungs of patients with silicosis but the mechanisms mediating their formation remain poorly understood. In this study, we sought to elucidate the mechanisms by which silica promotes foam cell formation in the lung, and to determine whether uptake of lipids alone is sufficient to drive TGF-β production by alveolar macrophages. Read More

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http://dx.doi.org/10.1038/s41598-018-36875-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344530PMC
January 2019
1 Read

Functional variant of the carboxypeptidase M (CPM) gene may affect silica-related pneumoconiosis susceptibility by its expression: a multistage case-control study.

Occup Environ Med 2019 Mar 23;76(3):169-174. Epub 2019 Jan 23.

Jiangsu Provincial Key Laboratory of Geriatrics, Department of Geriatrics, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.

Objectives: In a genome-wide association study, we discovered chromosome 12q15 (defined as rs73329476) as a silica-related pneumoconiosis susceptibility region. However, the causal variants in this region have not yet been reported.

Methods: We systematically screened eight potentially functional single-neucleotide polymorphism (SNPs) in the genes near rs73329476 (carboxypeptidase M () and cleavage and polyadenylation specific factor 6 ()) in a case-control study including 177 cases with silicosis and 204 healthy controls, matched to cases with years of silica dust exposure. Read More

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http://dx.doi.org/10.1136/oemed-2018-105545DOI Listing
March 2019
1 Read
3.267 Impact Factor

Neutrophil to lymphocyte ratio and platelet to lymphocyte ratio as haematological indices of inflammatory response in ceramic workers' silicosis.

Clin Respir J 2019 Jan 21. Epub 2019 Jan 21.

Department of Chest Diseases, Occupational and Environmental Diseases Hospital, Ankara, Turkey.

Introduction: Occupational exposure to crystalline silica over time may result in silicosis: a fatal, irreversible occupational disease leading to lung function impairment. A complex inflammatory process, excessive accumulation of mesenchymal cells and collagen production are the primary mechanisms underlying silicosis. Neutrophil to lymphocyte ratio (NLR) and the platelet to lymphocyte ratio (PLR) have emerged as representative indices of systemic inflammation. Read More

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http://dx.doi.org/10.1111/crj.12997DOI Listing
January 2019
5 Reads

Clinical Characteristics and Etiologies of Miliary Nodules in the US: A Single-Center Study.

Am J Med 2019 Jan 16. Epub 2019 Jan 16.

Divisions of Critical Care, Pulmonary and Sleep Medicine, Department of Internal Medicine. Electronic address:

Background: Miliary nodules have been typically described as a radiological manifestation of disseminated tuberculosis. However, miliary nodules are known to occur in a wide variety of conditions. The primary objective of the study was to identify clinical characteristics and etiologies of miliary nodules within our institution. Read More

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http://dx.doi.org/10.1016/j.amjmed.2018.12.030DOI Listing
January 2019
3 Reads

Aberrant expression of miR-125a-3p promotes fibroblast activation via Fyn/STAT3 pathway during silica-induced pulmonary fibrosis.

Toxicology 2019 Feb 15;414:57-67. Epub 2019 Jan 15.

Department of Occupational Medical and Environmental Health, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, China. Electronic address:

Various miRNAs are dysregulated during initiation and progression of pulmonary fibrosis. However, their function remains limited in silicosis. Here, we observed that miR-125a-3p was downregulated in silica-induced fibrotic murine lung tissues. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0300483X183047
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http://dx.doi.org/10.1016/j.tox.2019.01.007DOI Listing
February 2019
5 Reads
3.621 Impact Factor

Silicosis prevalence and incidence among Medicare beneficiaries.

Am J Ind Med 2019 Mar 18;62(3):183-191. Epub 2019 Jan 18.

Surveillance Branch, Respiratory Health Division, National Institute for Occupational Safety and Health (NIOSH), Centers for Disease Control and Prevention (CDC), Morgantown, West Virginia.

Introduction: Existing epidemiologic information on silicosis relies on mortality data.

Methods: We analyzed health insurance claims and enrollment information from 49 923 987 fee-for-service (FFS) Medicare beneficiaries aged ≥65 from 1999 to 2014. Three different definitions were developed to identify silicosis cases and results are presented as ranges of values for the three definitions. Read More

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http://dx.doi.org/10.1002/ajim.22944DOI Listing
March 2019
2 Reads

[Nursing intervention for respiratory function exercise in patients with silicosis complicated by stable chronic obstructive pulmonary disease].

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2018 Nov;36(11):844-846

Affiliated laigang hospital of taishan medical college, Laiwu 271104 Sandong Pronince, China.

To investigate the clinical effect of nursing intervention for respiratory function exercise in patients with silicosis complicated by stable chronic obstructive pulmonary disease (COPD) . A total of 60 patients with silicosis complicated by stable COPD who were hospitalized in Department of Occupational Diseases, Laigang Hospital Affiliated to Taishan Medical College, from August 2017 to April 2018 were enrolled and randomly divided into control group and observation group, with 30 patients in each group. The patients in the control group were given routine treatment and respiratory function exercise, and those in the observation group were given nursing intervention in addition to the treatment in the control group. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1001-9391.2018.11.012DOI Listing
November 2018
2 Reads

[Expression and significance of NLRP3/IL-1β/TGF-β(1) signal axis in rat model of silicosis pulmonary fibrosis].

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2018 Nov;36(11):819-823

Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250355, China.

To investigate the expression and significance of NLRP3/IL-1β/TGF-β(1) signal axis in a rat model of silicosis and pulmonary fibrosis. Eighty healthy Wistar male rats of SPF grade were randomly divided into 4 groups: high (100 mg/ml) , medium (50 mg/ml) , low (25 mg/ml) concentration SiO(2) dusting group and normal negative control. Group, 20 in each group. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1001-9391.2018.11.005DOI Listing
November 2018
5 Reads

Tumor necrosis factor gene polymorphisms are associated with silicosis: a systemic review and meta-analysis.

Biosci Rep 2019 Feb 5;39(2). Epub 2019 Feb 5.

Central Office, Suzhou National New and Hi-tech Industrial Development Zone Center for Disease Control and Prevention, Suzhou, Jiangsu 215011, China

Studies investigating association between tumor necrosis factor (TNF) gene polymorphisms and silicosis susceptibility report conflicting results. The aim of this meta-analysis was to assess association between TNF gene polymorphisms and silicosis susceptibility. A systematic literature search was conducted to find relevant studies. Read More

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http://dx.doi.org/10.1042/BSR20181896DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361771PMC
February 2019
2 Reads

Proteomic profile of TGF-β1 treated lung fibroblasts identifies novel markers of activated fibroblasts in the silica exposed rat lung.

Exp Cell Res 2019 Feb 11;375(2):1-9. Epub 2019 Jan 11.

Basic Medical College, North China University of Science and Technology, Tangshan, China; School of public health, North China University of Science and Technology, Tangshan, China; The Hebei key laboratory for organ fibrosis research, North China University of Science and Technology, Tangshan, China. Electronic address:

We performed liquid chromatography-tandem mass spectrometry (LC-MS/MS) on control and TGF-β1-exposed rat lung fibroblasts to identify proteins differentially expressed between cell populations. A total of 196 proteins were found to be differentially expressed in response to TGF-β1 treatment. Guided by these results, we next determined whether similar changes in protein expression were detectable in the rat lung after chronic exposure to silica dust. Read More

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http://dx.doi.org/10.1016/j.yexcr.2019.01.010DOI Listing
February 2019
5 Reads

Exposure to Respirable Crystalline Silica in the GB Brick Manufacturing and Stone Working Industries.

Ann Work Expo Health 2019 Feb;63(2):184-196

Health and Safety Executive (HSE), Buxton, Derbyshire, UK.

The aim of this work was to benchmark respirable crystalline silica (RCS) exposures in brick manufacturing and stone working sectors in Great Britain. This will contribute to a larger programme of work, which will be used to better understand the role of health surveillance in preventing the development of further cases of silicosis and chronic obstructive pulmonary disease. This work was undertaken by means of site visits to measure RCS and respirable dust exposures and assess exposure controls. Read More

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http://dx.doi.org/10.1093/annweh/wxy103DOI Listing
February 2019
2 Reads

Risk factors and control strategies for silicotuberculosis as an occupational disease.

New Microbes New Infect 2019 Jan 15;27:75-77. Epub 2018 Nov 15.

)Shahrekord University of Medical Sciences, Shahrekord, Iran.

Silicotuberculosis is critical in community settings among workers and employees exposed to silica dust. Older age of entry (>30 years), male sex, infection with human immunodeficiency virus (HIV), exposure duration, smoking, chronic obstructive pulmonary disease, migration, the severity of the silicosis and the intensity of the exposure are potential risk factors. Lack of timely diagnosis and treatment for tuberculosis (TB) may also raise the rate of infection; previous treatment of TB is possibly associated with the development of silicotuberculosis in more than half of patients, increasing with age (>40 years). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S20522975183010
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http://dx.doi.org/10.1016/j.nmni.2018.11.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319297PMC
January 2019
6 Reads

Combined silicosis and mixed dust pneumoconiosis with rapid progression: A case report and literature review.

World J Clin Cases 2018 Dec;6(16):1164-1168

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, College of Medicine, Ewha Womans University, Seoul 15871, South Korea.

Background: Rapidly progressive pneumoconiosis (RPP) occasionally occurs in coal workers, particularly those with high exposure to silica. Here, we report the case of a 64-year-old male miller with RPP.

Case Summary: The patient had a persistent cough for one month and had been clinically diagnosed with pulmonary tuberculosis in 2011. Read More

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http://dx.doi.org/10.12998/wjcc.v6.i16.1164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306638PMC
December 2018
2 Reads

Circular RNAs: a rising star in respiratory diseases.

Respir Res 2019 Jan 5;20(1). Epub 2019 Jan 5.

Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, China.

Circular RNAs (CircRNAs), as a new class of non-coding RNA molecules that, unlike linear RNAs, have covalently closed loop structures from the ligation of exons, introns, or both. CircRNAs are widely expressed in various organisms in a specie-, tissue-, disease- and developmental stage-specific manner, and have been demonstrated to play a vital role in the pathogenesis and progression of human diseases. An increasing number of recent studies has revealed that circRNAs are intensively associated with different respiratory diseases, including lung cancer, acute respiratory distress syndrome, pulmonary hypertension, pulmonary tuberculosis, and silicosis. Read More

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https://respiratory-research.biomedcentral.com/articles/10.1
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http://dx.doi.org/10.1186/s12931-018-0962-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321672PMC
January 2019
6 Reads

[Extracorporeal membrane oxygenation as a bridge to lung transplantation].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2018 Dec;30(12):1167-1172

Department of Intensive Care Unit, Affiliated Wuxi People's Hospital, Nanjing Medical University, Wuxi 214023, Jiangsu, China (Xia W, Xu HY); Department of Thoracic Surgery, Affiliated Wuxi People's Hospital, Nanjing Medical University, Wuxi 214023, Jiangsu, China (Mao WJ, Chen JY). Corresponding author: Xu Hongyang, Email:

Objective: To evaluate the effect of extracorporeal membrane oxygenation (ECMO) as a bridge to lung transplantation (LTx).

Methods: The clinical data of 18 patients with end-stage lung diseases was retrospectively reviewed, using ECMO as a bridge to LTx in intensive care unit of Affiliated Wuxi People's Hospital from January 2015 to December 2017. Clinical parameters were obtained from these patients, including gender, age, primary disease, preoperative lactate level, preoperative leukocyte, operation modality (unilateral or bilateral), type of ECMO, ECMO support time as a bridge to LTx, ECMO support time after operation, total usage time of ECMO, ECMO associated complications, primary graft dysfunction (PGD), successful ECMO weaning, and survival. Read More

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http://dx.doi.org/10.3760/cma.j.issn.2095-4352.2018.012.013DOI Listing
December 2018
2 Reads

Metachronous Pulmonary Neoplasms in Lung Transplantation-When They Arise in the Donor Lung: A Case Report.

Transplant Proc 2018 Dec 6;50(10):4075-4079. Epub 2018 Sep 6.

Pulmonology Department, Hospital Pedro Hispano, Senhora da Hora, Matosinhos, Portugal.

Lung cancer (LC) is uncommon among lung transplant recipients, being most often described in the native lung of single-lung transplant recipients. Its appearance in the transplanted lung is a very uncommon phenomenon, in which donor and recipient factors appear to be involved. We present a case of 2 distinct metachronous lung neoplasms diagnosed in the transplanted lung of a non-smoker patient with progressive massive silicosis (PMS), who underwent left unipulmonary transplantation at 39 years. Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.08.051DOI Listing
December 2018
1 Read

Association between Plasma HMGB-1 and Silicosis: A Case-Control Study.

Int J Mol Sci 2018 Dec 14;19(12). Epub 2018 Dec 14.

Department of Occupational & Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

High-mobility group box-1 (HMGB-1) has been associated with fibrotic diseases. However, the role of HMGB-1 in silicosis is still uncertain. In this study, we conducted a case-control study involving 74 patients with silicosis and 107 age/gender-matched healthy controls in China. Read More

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http://dx.doi.org/10.3390/ijms19124043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320808PMC
December 2018
5 Reads
2.862 Impact Factor

Silica, silicosis and lung cancer: what level of exposure is acceptable?

Med Lav 2018 Dec 20;109(6):478-480. Epub 2018 Dec 20.

Department of Public Health, University of Naples Federico II, Italy.

Silica, silicosis and lung cancer: what level of exposure is acceptable? Read More

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http://dx.doi.org/10.23749/mdl.v109i6.7928DOI Listing
December 2018
10 Reads

Evaluation of the Bioavailability and Translocation of Selected Heavy Metals by and L for a South African Power Utility Coal Fly Ash.

Int J Environ Res Public Health 2018 12 13;15(12). Epub 2018 Dec 13.

Environmental Remediation and Geopollution Group, Department of Geology, Faculty of Science, Ekiti State University, Ado Ekiti, Private Mail Bag 5363, Ado Ekiti 360001 Nigeria.

This study evaluated the physicochemical and mineralogical properties, mobile chemical species bioavailability and translocation in and L. plants of a South African coal-fired power utility. Coal-fly-ash (CFA) disposal is associated with various environmental and health risks, including air, soil, surface, and groundwater pollution due to the leaching of toxic heavy metals; these ends up in food webs affecting human health, while repeated inhalation causes bronchitis, silicosis, hair loss, and lung cancer. Read More

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http://dx.doi.org/10.3390/ijerph15122841DOI Listing
December 2018
2 Reads

Artificial stone-associated silicosis in Belgium: response.

Occup Environ Med 2019 Feb 11;76(2):134. Epub 2018 Dec 11.

Thoracic Medicine, St Vincent's Hospital, Sydney, New South Wales, Australia.

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http://oem.bmj.com/lookup/doi/10.1136/oemed-2018-105563
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http://dx.doi.org/10.1136/oemed-2018-105563DOI Listing
February 2019
3 Reads

STING-dependent sensing of self-DNA drives silica-induced lung inflammation.

Nat Commun 2018 12 6;9(1):5226. Epub 2018 Dec 6.

CNRS, UMR7355, Orleans, 45071, France.

Silica particles induce lung inflammation and fibrosis. Here we show that stimulator of interferon genes (STING) is essential for silica-induced lung inflammation. In mice, silica induces lung cell death and self-dsDNA release in the bronchoalveolar space that activates STING pathway. Read More

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http://www.nature.com/articles/s41467-018-07425-1
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http://dx.doi.org/10.1038/s41467-018-07425-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283886PMC
December 2018
15 Reads

Reducing Lead and Silica Dust Exposures in Small-Scale Mining in Northern Nigeria.

Ann Work Expo Health 2019 Jan;63(1):1-8

Occupational Knowledge International, San Francisco, CA, USA.

Purpose: An ongoing health crisis across a large area of Northern Nigeria has resulted in hundreds of deaths and thousands of cases of lead poisoning from artisanal small-scale gold mining. Occupational Knowledge International (OK International) and Doctors Without Borders/Médecins Sans Frontières (MSF) have formed a partnership to conduct a pilot project to introduce safer mining practices in selected communities. The primary objective was to reduce lead exposures among artisanal small-scale miners and minimize take home exposures by reducing dust contamination on clothing and body surfaces. Read More

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https://academic.oup.com/annweh/advance-article/doi/10.1093/
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http://dx.doi.org/10.1093/annweh/wxy095DOI Listing
January 2019
11 Reads

Associated factors with unsuccessful tuberculosis treatment outcomes among tuberculosis/HIV coinfected patients with drug-resistant tuberculosis.

Int J Mycobacteriol 2018 Oct-Dec;7(4):347-354

Department of Statistics, University of Fort Hare, Eastern Cape, South Africa.

Background: In Sub-Saharan Africa, HIV endemic has substantially contributed to the increasing tuberculosis (TB) incidence. The joint effect of the HIV and TB pestilences has confronted the feeble systems of healthcare in resource-limited countries.

Methods: The aim of this study was to determine the pathological attributes, outcomes of TB treatment, and the contributing factors of unsuccessful results among TB/HIV patients. Read More

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http://dx.doi.org/10.4103/ijmy.ijmy_140_18DOI Listing
December 2018
2 Reads

MicroRNA-29b Mediates Lung Mesenchymal-Epithelial Transition and Prevents Lung Fibrosis in the Silicosis Model.

Mol Ther Nucleic Acids 2018 Nov 6;14:20-31. Epub 2018 Nov 6.

Department of Occupational Health and Environmental Health, School of Public Health, Capital Medical University, Beijing 100069, China; Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing 100069, China. Electronic address:

Lung epithelial-mesenchymal transition (EMT) plays an important role in silicosis fibrosis. The reverse process of EMT is mesenchymal-epithelial transition (MET), which is viewed as an anti-EMT therapy and is a good target toward fibrosis. MicroRNAs (miRNAs) have emerged as potent regulators of EMT and MET programs, and, hence, we tested the miRNA expression using microarray assay and investigated their roles in silica-induced EMT in lung epithelial cells. Read More

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http://dx.doi.org/10.1016/j.omtn.2018.10.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282658PMC
November 2018
9 Reads

Outcomes after lung transplantation for patients with occupational lung diseases.

Clin Transplant 2019 Jan 30;33(1):e13460. Epub 2018 Dec 30.

Division of Lung Failure and Lung Transplantation, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania.

Occupational lung diseases (OLD) including silicosis, asbestosis, and pneumoconiosis progress to end stage lung disease requiring lung transplantation (LT). Prognosis and treatment of OLDs are poorly understood and a paucity of data exists regarding LT outcomes. Additionally, transplant operative complexity for patients with OLD is high. Read More

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http://doi.wiley.com/10.1111/ctr.13460
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http://dx.doi.org/10.1111/ctr.13460DOI Listing
January 2019
20 Reads

Silicosis, sarcoidosis and systemic sclerosis in the same patient.

Med Clin (Barc) 2018 Nov 27. Epub 2018 Nov 27.

Unidad de Enfermedades Sistémicas, Reumatología, Hospital General de Granollers, Granollers, Barcelona, España.

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http://dx.doi.org/10.1016/j.medcli.2018.10.007DOI Listing
November 2018
1 Read

Multiorgan accelerated silicosis misdiagnosed as sarcoidosis in two workers exposed to quartz conglomerate dust.

Occup Environ Med 2019 Mar 4;76(3):178-180. Epub 2018 Dec 4.

Department of Cardiologic, Thoracic and Vascular Sciences, University of Padova, Padova, Italy.

Introduction: Clusters of silicosis cases have been reported in the fabrication of quartz conglomerate, a new high-silica-content artificial stone for kitchen and bathroom benchtops (countertops).

Aim: We describe two cases of accelerated-type silicosis with hepatic granulomas arising in workers exposed to artificial quartz conglomerates.

Methods: A confident diagnosis of multiorgan silicosis was based on high level of respirable silica in the workplace, typical radiological alterations in chest high-resolution CT, histological findings in the lung and liver, and detection of silica crystals in both tissues by phase-contrast polarising light microscopy and scanning electron microscopy and energy dispersive spectroscopy. Read More

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http://dx.doi.org/10.1136/oemed-2018-105462DOI Listing
March 2019
4 Reads

Targeted migration of bone marrow mesenchymal stem cells inhibits silica-induced pulmonary fibrosis in rats.

Stem Cell Res Ther 2018 Dec 4;9(1):335. Epub 2018 Dec 4.

Department of Occupational and Environmental Health, School of Public Health, Capital Medical University, No. 10, Xi toutiao outside You anmen, Beijing, 100069, China.

Background: Silicosis is a common occupational disease, characterized by silicotic nodules and diffuse pulmonary fibrosis. We demonstrated an anti-fibrotic effect of bone marrow mesenchymal stem cells (BMSCs) in silica-induced lung fibrosis. In the present study, we sought to clarify the homing ability of BMSCs and the specific mechanisms for their effects. Read More

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http://dx.doi.org/10.1186/s13287-018-1083-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280342PMC
December 2018
2 Reads

Silicosis in underground miners in Lubumbashi, Democratic Republic of the Congo: 27 cases.

Med Sante Trop 2018 Nov 29. Epub 2018 Nov 29.

Institute for work and health, Service of Occupational Medecine, University of Lausanne and Geneva 1066 Epalinges-Lausanne, Suisse.

Silicosis is one of the most prevalent occupational lung diseases and a public health problem throughout the world. Underground miners of copper and cobalt are exposed to the dust of these minerals and thus to the risk of developing silicosis. The objective of this report was to describe a series of silicosis cases in miners exposed to mineral dusts at a mining company operating since the colonial era in Lubumbashi, Katanga province, in the Democratic Republic of the Congo (DRC). Read More

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http://dx.doi.org/10.1684/mst.2018.0812DOI Listing
November 2018
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Silicosis and lung cancer: current perspectives.

Lung Cancer (Auckl) 2018 26;9:91-101. Epub 2018 Oct 26.

Cancer and Inflammation Program, National Cancer Institute, Frederick, MD 21702, USA,

"Silica" refers to crystalline particles formed by the combination of silicon with oxygen. Inhalation of silica particles promotes the development of pulmonary fibrosis that over prolonged periods increases the risk of lung cancer. The International Agency for Research on Cancer (IARC) classified crystalline silica as a human carcinogen in 1997. Read More

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http://dx.doi.org/10.2147/LCTT.S156376DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207090PMC
October 2018
1 Read

Pneumatic rock drill vs. electric rotary hammer drill: Productivity, vibration, dust, and noise when drilling into concrete.

Appl Ergon 2019 Jan 13;74:31-36. Epub 2018 Aug 13.

Department of Environmental Health Sciences, University of Michigan, Ann Arbor, MI, USA.

Objectives: Both pneumatic rock drills and electric rotary hammer drills are used for drilling large holes (e.g., 10-20 mm diameter) into concrete for structural upgrades to buildings, highways, bridges, and airport tarmacs. Read More

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http://dx.doi.org/10.1016/j.apergo.2018.08.005DOI Listing
January 2019
1 Read

[Causes of mediastinal/hilar granulomatous lymphadenitis].

Tuberk Toraks 2018 Sep;66(3):212-216

Department of Pathology, Faculty of Medicine, Karadeniz Teknik University, Trabzon, Turkey.

Introduction: Granulomatous lung disease (GLD) is caused by a wide range of conditions and it is challenge for pulmonologist. A detailed history of exposures is fundamental in GDL and has been found pivotal to reach a precise diagnosis.

Materials And Methods: Between September 2014 and December 2016, the distribution of patients diagnosed with granulomatous lymphadenitis in the mediastinal/hilar lymph nodes by endobronchial ultrasound (EBUS) or mediastinoscopy was analyzed. Read More

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http://dx.doi.org/10.5578/tt.67018DOI Listing
September 2018
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miR-542-5p Attenuates Fibroblast Activation by Targeting Integrin α6 in Silica-Induced Pulmonary Fibrosis.

Int J Mol Sci 2018 Nov 22;19(12). Epub 2018 Nov 22.

Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 210029, China.

Silicosis is a very serious occupational disease and it features pathological manifestations of inflammatory infiltration, excessive proliferation of fibroblasts and massive depositions of the extracellular matrix in the lungs. Recent studies described the roles of a variety of microRNAs (miRNAs) in fibrotic diseases. Here, we aimed to explore the potential mechanism of miR-542-5p in the activation of lung fibroblasts. Read More

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http://dx.doi.org/10.3390/ijms19123717DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320929PMC
November 2018
7 Reads
2.860 Impact Factor

A Rare Cause of Dysphagia and Cough: Bronchoesophageal Fistula from Silicosis.

ACG Case Rep J 2018 7;5:e77. Epub 2018 Nov 7.

Department of Internal Medicine, James J. Peters VA Medical Center, Bronx, NY.

Dysphagia and cough in an older male smoker raise concern for malignancy. However, a history of environmental exposures led to a much more interesting diagnosis in this case of pneumoconiosis due to silicosis. Silicosis is an uncommon pulmonary disease with rare associated gastrointestinal symptoms. Read More

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http://dx.doi.org/10.14309/crj.2018.77DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224867PMC
November 2018
15 Reads

Role of SOD3 in silica-related lung fibrosis and pulmonary vascular remodeling.

Respir Res 2018 Nov 20;19(1):221. Epub 2018 Nov 20.

Department of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, University of Louisville, 505 S. Hancock Street, CTR Bldg., room 524, Louisville, KY, 40202, USA.

Background: Work-place exposure to silica dust may lead to progressive lung inflammation culminating in the development of silicosis, an irreversible condition that can be complicated by onset of pulmonary hypertension (PH). The molecular mechanisms leading to the development of PH and lung fibrosis in response to silica are not well understood. Oxidant/antioxidant imbalance in the lung may promote fibroproliferation and vascular smooth muscle proliferation, ultimately leading to the development of PH. Read More

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https://respiratory-research.biomedcentral.com/articles/10.1
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http://dx.doi.org/10.1186/s12931-018-0933-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245633PMC
November 2018
9 Reads

Focusing on Coal Workers' Lung Diseases: A Comparative Analysis of China, Australia, and the United States.

Int J Environ Res Public Health 2018 11 16;15(11). Epub 2018 Nov 16.

Sustainable Minerals Institute, The University of Queensland, Brisbane 4072, Australia.

China has high and increasing annual rates of occupational lung diseases such as pneumoconiosis and silicosis. In contrast, Australia and the United States of America (USA) have greatly lowered their annual rates of lung diseases since the 1970s. This paper systematically compared and analysed the multi-elements of coal dust management and health management in these three countries to provide a reference for China. Read More

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http://dx.doi.org/10.3390/ijerph15112565DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266950PMC
November 2018
1 Read

Exposure‒response relationships for silicosis and its progression in industrial sand workers.

Scand J Work Environ Health 2018 Nov 18. Epub 2018 Nov 18.

Medical Biostatistics Unit, University of Vermont Larner College of Medicine, 105 Carrigan Dr., Burlington, VT 05405, USA.

Objectives This study aimed to characterize the relationship between radiographic silicosis and exposure to respirable quartz and determine how exposure affects disease progression. Methods Surveillance chest radiographs from a cohort of 1902 workers were examined to identify 67 cases of radiographic silicosis and 167 matched controls. Exposures were estimated by linking work histories to a job exposure matrix (JEM) based on samples collected by the participating companies and historical estimates. Read More

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http://dx.doi.org/10.5271/sjweh.3786DOI Listing
November 2018
1 Read

Shorter telomere length and DNA hypermethylation in peripheral blood cells of coal workers.

Mutat Res 2018 Dec 28;836(Pt B):36-41. Epub 2018 Mar 28.

Laboratory of Genetic Toxicology, Postgraduate Program in Molecular and Cell Biology Applied to Health, Lutheran University of Brazil (ULBRA), Canoas, RS, Brazil. Electronic address:

Coal is a mixture of several chemicals, mainly inorganic elements and polycyclic aromatic hydrocarbons, many of which have mutagenic and carcinogenic effects. Pneumoconiosis, fibrosis, asbestosis, silicosis, emphysema, loss of lung function and cancer are some examples of coal-related disorders. The aim of this study was to analyze coal miners with respect to telomere length (TL) and percentage (%) of global DNA methylation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13835718173018
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http://dx.doi.org/10.1016/j.mrgentox.2018.03.009DOI Listing
December 2018
13 Reads