10,224 results match your criteria Silence [Journal]


22kHz and 55kHz ultrasonic vocalizations differentially influence neural and behavioral outcomes: Implications for modeling anxiety via auditory stimuli in the rat.

Behav Brain Res 2018 Dec 3. Epub 2018 Dec 3.

Developmental Neuropsychobiology Lab, Department of Psychology, Northeastern University, 360 Huntington Ave NI125, Boston, MA, 02115, United States. Electronic address:

The communicative role of ultrasonic vocalizations (USVs) in rats is well established, with distinct USVs indicative of different affective states. USVs in the 22 kHz range are typically emitted by adult rats when in anxiety- or fear-provoking situations (e.g. Read More

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December 2018

Senior stakeholder views on policies to foster a culture of openness in the English National Health Service: a qualitative interview study.

J R Soc Med 2018 Dec 3:141076818815509. Epub 2018 Dec 3.

1 The Healthcare Improvement Studies Institute, University of Cambridge, Cambridge, CB2 0AH, UK.

Objectives: To examine the experiences of clinical and managerial leaders in the English healthcare system charged with implementing policy goals of openness, particularly in relation to improving employee voice.

Design: Semi-structured qualitative interviews.

Setting: National Health Service, regulatory and third-sector organisations in England. Read More

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December 2018

LINC00857 contributes to hepatocellular carcinoma malignancy via enhancing epithelial-mesenchymal transition.

J Cell Biochem 2018 Dec 3. Epub 2018 Dec 3.

Department of General Surgery, Liaocheng People's Hospital, 67 Dongchang West Road, Liaocheng, Shandong, China.

Hepatocellular carcinoma (HCC) remains the fifth most frequent cancer with high mortality rate worldwide. However, the underlying molecular mechanisms of HCC progression are still barely known. Long noncoding RNAs (lncRNAs) have been recognized as significant therapeutic targets for HCC. Read More

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December 2018

A prospective intervention to improve happiness and reduce burnout in oncologists.

Support Care Cancer 2018 Nov 30. Epub 2018 Nov 30.

Division of Medical Oncology, Department of Oncology, University of Alberta, Cross Cancer Institute, Edmonton, Canada.

Background: There is a paucity of data about effective interventions to improve happiness and reduce burnout in oncologists. Benjamin Franklin developed a 13-week program of "necessary activities" or "virtues" (temperance, silence, order, resolution, frugality, industry, sincerity, justice, moderation, cleanliness, tranquility, chastity, and humility) to follow, in his attempt at self-improvement. In this pilot study, we explored whether using a modified version of this was associated with any discernable impact on physician happiness, burnout, or compliance with each of the virtues. Read More

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November 2018

Optimization of double-stranded RNAi intrathoracic injection method in .

Entomol Res 2018 Jul 12;48(4):269-278. Epub 2018 Jul 12.

Access Bio, Inc. Somerset, NJ 08873, USA.

RNA interference is widely used to analyze gene functions via phenotypic knockdown of target transcripts in mosquitoes, which transmit numerous mosquito-borne diseases. Functional analysis of mosquito genes is indispensable to understand and reduce transmission of mosquito-borne diseases in mosquitoes. Intrathoracic injection of double-stranded RNA (dsRNA) remains the simplest and most customizable method in mosquitoes for functional analysis of the genes of interest. Read More

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July 2018
1 Read

Effect of Rotating Auditory Scene on Postural Control in Normal Subjects, Patients With Bilateral Vestibulopathy, Unilateral, or Bilateral Cochlear Implants.

Front Neurol 2018 16;9:972. Epub 2018 Nov 16.

Department of Otolaryngology-Head and Neck Surgery, Dijon University Hospital, Dijon, France.

The aim of this study was to investigate the impact of a rotating sound stimulation on the postural performances in normal subjects, patients with bilateral vestibulopathy (BVP), unilateral (UCI), and bilateral (BCI) cochlear implantees. Sixty-nine adults were included (32 women and 37 men) in a multicenter prospective study. The group included 37 healthy subjects, 10 BVP, 15 UCI, and 7 BCI patients. Read More

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November 2018

Targeting CD44 by CRISPR-Cas9 in Multi-Drug Resistant Osteosarcoma Cells.

Cell Physiol Biochem 2018 Nov 30;51(4):1879-1893. Epub 2018 Nov 30.

Department of Orthopedics, The Second Xiangya Hospital, Central South University, Changsha, China.

Background/aims: Drug resistance is the main difficulty for the current treatment for osteosarcoma. Cluster of differentiation 44 (CD44) is a receptor for hyaluronic acid (HA) and HA-binding has been proven to participate in various biological tumor activities, including tumor progression, metastasis and drug resistance. In this study, we aimed to determine the effects of CD44 on migration, invasion, proliferation, and the drug-sensitivity of osteosarcoma. Read More

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November 2018
1 Read

Temperature Sensing Is Distributed throughout the Regulatory Network that Controls FLC Epigenetic Silencing in Vernalization.

Cell Syst 2018 Nov 20. Epub 2018 Nov 20.

John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK. Electronic address:

Many organisms need to respond to complex, noisy environmental signals for developmental decision making. Here, we dissect how Arabidopsis plants integrate widely fluctuating field temperatures over month-long timescales to progressively upregulate VERNALIZATION INSENSITIVE3 (VIN3) and silence FLOWERING LOCUS C (FLC), aligning flowering with spring. We develop a mathematical model for vernalization that operates on multiple timescales-long term (month), short term (day), and current (hour)-and is constrained by experimental data. Read More

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November 2018

Inhibition of BAP31 expression inhibits cervical cancer progression by suppressing metastasis and inducing intrinsic and extrinsic apoptosis.

Biochem Biophys Res Commun 2018 Nov 29. Epub 2018 Nov 29.

Department of Pathology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China. Electronic address:

Cervical cancer is reported as one of the most lethal types of cancer among female. However, extensive studies of the molecular mechanisms that regulate the progression of cervical cancer are still required. B-cell associated protein (BAP)-31 is a 28-kDa integral membrane protein in the endoplasmic reticulum (ER), playing essential role in modulating various physiological processes. Read More

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November 2018

[Expression Changes of Serum Transferrin Receptor and Its Mechanism in Children with Acute Leukemia].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2018 Dec;26(6):1637-1643

Department of Clinical Laboratorial Examination, Foshan first people's Hospital, Foshan 528000, Guangdong Province,China.

Objective: To investigate the expression changes of serum transferrin receptor(sTFR) and its related mechanism in children with acute leukemia(AL).

Methods: Forty-six children with acute leukemia treated in our hospital from June 2016 to June 2017 were selected and enrolled in the AL group, 40 healthy children were enrolled in the control group. The related clinical data were recorded, including age, sex and CNSL level. Read More

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December 2018

Intracellular delivery of nucleic acid by cell-permeable hPP10 peptide.

J Cell Physiol 2018 Dec 4. Epub 2018 Dec 4.

Hubei Key Lab of Tumor Microenvironment and Immunotherapy, China Three Gorges University, Yichang, China.

Although gene therapy offers hope against incurable diseases, nonreplicating transduction vectors remain lacking. We have previously characterized a cell-penetrating peptide hPP10 for the delivery of various cargoes; however, whether hPP10 can mediate nucleic acid delivery is still unknown. Here, examining via different ways, we demonstrate that hPP10 stably complexes with plasmid DNA (pDNA) and safely mediates nucleic acid transfection. Read More

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December 2018

Effect of Gpx3 gene silencing by siRNA on apoptosis and autophagy in chicken cardiomyocytes.

J Cell Physiol 2018 Dec 4. Epub 2018 Dec 4.

Department of Veterinary Medicine, College of Veterinary Medicine, Northeast Agricultural University, Harbin, China.

Glutathione peroxidase 3 (Gpx3), as an important selenoprotein, is the most crucial antioxidant defense in cardiomyocytes. However, the role of Gpx3 in Se-deficient cardiomyocyte damage still less reported. Here, we developed Gpx3 silence cardiomyocytes culture model (small interfering RNA; siRNA) for research the crosstalk between autophagy and apoptosis. Read More

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December 2018
6 Reads

SIRT6 deacetylase activity regulates NAMPT activity and NAD(P)(H) pools in cancer cells.

FASEB J 2018 Dec 4:fj201800321R. Epub 2018 Dec 4.

Section of Biochemistry, Department of Experimental Medicine, Center for Excellence in Biomedical Research (CEBR), University of Genoa, Genoa, Italy.

Nicotinamide phosphoribosyltransferase (NAMPT) is the rate-limiting enzyme in the NAD salvage pathway from nicotinamide. By controlling the biosynthesis of NAD, NAMPT regulates the activity of NAD-converting enzymes, such as CD38, poly-ADP-ribose polymerases, and sirtuins (SIRTs). SIRT6 is involved in the regulation of a wide number of metabolic processes. Read More

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December 2018

CRISPR/Cas9; A robust technology for producing genetically engineered plants.

Cell Mol Biol (Noisy-le-grand) 2018 Nov 30;64(14):31-38. Epub 2018 Nov 30.

Department of Bioinformatics and Biotechnology, Government College University Faisalabad, Pakistan.

CRISPR/Cas9 is a technology evolved from modified type II immune system of bacteria and archaea. Exploitation of this bacterial immune system in all eukaryotes including plants may lead to site-specific targeted genome engineering. Genome engineering is objectively utilized to express/silence a trait harbouring gene in the plant genome. Read More

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November 2018

Long non-coding RNA HOTTIP affects renal cell carcinoma progression by regulating autophagy via the PI3K/Akt/Atg13 signaling pathway.

J Cancer Res Clin Oncol 2018 Dec 3. Epub 2018 Dec 3.

Department of Urology, Renmin Hospital of Wuhan University, Wuhan, 430060, China.

Objective: Renal cell carcinoma (RCC) is the most common malignancy of the urinary system, and it is a serious threat to human health. HOXA transcript at the distal tip (HOTTIP), located at the 5' end of the HOXA locus, is a long non-coding RNA that has been newly discovered in recent years. It has been reported to promote the development of several types of tumors. Read More

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December 2018

miR-141 alleviates LPS-induced inflammation injury in WI-38 fibroblasts by up-regulation of NOX2.

Life Sci 2018 Nov 27. Epub 2018 Nov 27.

Neonatal Ward of Department of Pediatrics, Jining No. 1 People's Hospital, Jining 272011, China. Electronic address:

Aims: The roles of miR-141 in various types of cancers and inflammatory bowel diseases are researched, whereas, little information about its function in lung inflammation is available. This study was designed to explore the effect of miR-141 on inflammation injury in WI-38 cells, possibly providing basis for targeted therapeutic strategy for treatment of infantile pneumonia.

Main Methods: WI-38 cells were treated with LPS to construct cell model with inflammation injury. Read More

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November 2018
1 Read

RNF6 facilitates metastasis and radioresistance in hepatocellular carcinoma through ubiquitination of FoxA1.

Exp Cell Res 2018 Nov 26. Epub 2018 Nov 26.

Department of General Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province 330006, China. Electronic address:

Ring finger protein 6 (RNF6), a RING-domain E3 ubiquitin Ligase, functions as a potential tumor promoter in several caners. However, the function and clinical significance of RNF6 in hepatocellular carcinoma (HCC) remains unclear. Here, we found that high RNF6 expression was detected frequently in primary HCC tissues, and was closely associated with malignant phenotype and shorter survival among the HCC patients. Read More

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November 2018

Exploring the use of fact-based and story-based learning materials for HIV/STI prevention and sexual health promotion with South Asian women in Toronto, Canada.

Health Educ Res 2018 Nov 27. Epub 2018 Nov 27.

Daphne Cockwell School of Nursing, Faculty of Community Services, Ryerson University, 350 Victoria Street, Toronto, ON M5B 2K3, Canada.

Story-based learning is well recognized as an effective strategy for adult health education. However, there is a scarcity of research on story-based health education among women in South Asian diasporic communities. To address this gap, we undertook a pilot study in Toronto to explore how South Asian women respond to the use of fact-based and story-based materials for HIV/STI prevention. Read More

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November 2018

LINC00707 contributes to hepatocellular carcinoma progression via sponging miR-206 to increase CDK14.

J Cell Physiol 2018 Nov 29. Epub 2018 Nov 29.

Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, The Fifth Affiliated Hospital of Wenzhou Medical University, Affiliated Lishui Hospital of Zhejiang University, The Central Hospital of Zhejiang Lishui, Lishui, China.

Recently, increasing numbers of long noncoding RNAs (lncRNAs) have been found to be aberrantly expressed in various cancers. However, the roles of lncRNAs in hepatocellular carcinoma (HCC) progression is largely unknown. In our current study, we identified that long intergenic nonprotein-coding RNA 707 (LINC00707) was remarkably elevated in HCC cells, indicating that LINC00707 was involved in HCC development. Read More

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November 2018

Silencing of Hypoglossal Motoneurons Leads to Sleep Disordered Breathing in Lean Mice.

Front Neurol 2018 14;9:962. Epub 2018 Nov 14.

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States.

Obstructive Sleep Apnea (OSA) is a prevalent condition and a major cause of morbidity and mortality in Western Society. The loss of motor input to the tongue and specifically to the genioglossus muscle during sleep is associated with pharyngeal collapsibility and the development of OSA. We applied a novel chemogenetic method to develop a mouse model of sleep disordered breathing Our goal was to reversibly silence neuromotor input to the genioglossal muscle using an adeno-associated viral vector carrying inhibitory designer receptors exclusively activated by designer drugs AAV5-hM4Di-mCherry (DREADD), which was delivered bilaterally to the hypoglossal nucleus in fifteen C57BL/6J mice. Read More

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November 2018
2 Reads

NP220 mediates silencing of unintegrated retroviral DNA.

Nature 2018 Nov 28. Epub 2018 Nov 28.

Howard Hughes Medical Institute, Columbia University, New York, NY, USA.

The entry of foreign DNA into many mammalian cell types triggers the innate immune system, a complex set of responses to prevent infection by pathogens. One aspect of the response is the potent epigenetic silencing of incoming viral DNAs, including the extrachromosomal DNAs that are formed immediately after infection by retroviruses. These unintegrated viral DNAs are very poorly transcribed in all cells, even in permissive cells, in contrast to the robust expression that is observed after viral integration. Read More

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November 2018
8 Reads

Discovery and annotation of a novel transposable element family in Gossypium.

BMC Plant Biol 2018 Nov 28;18(1):307. Epub 2018 Nov 28.

State Key Laboratory of Cotton Biology, Institute of Cotton Research of Chinese Academy of Agricultural Science, Anyang, 455000, Henan, China.

Background: Fluorescence in situ hybridization (FISH) is an efficient cytogenetic technology to study chromosome structure. Transposable element (TE) is an important component in eukaryotic genomes and can provide insights in the structure and evolution of eukaryotic genomes.

Results: A FISH probe derived from bacterial artificial chromosome (BAC) clone 299N22 generated striking signals on all 26 chromosomes of the cotton diploid A genome (AA, 2x=26) but very few on the diploid D genome (DD, 2x=26). Read More

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November 2018
3.813 Impact Factor

Short-term Sahaja Yoga meditation training modulates brain structure and spontaneous activity in the executive control network.

Brain Behav 2018 Nov 28:e01159. Epub 2018 Nov 28.

NeTS Center, Scuola Universitaria Superiore IUSS, Pavia, Italy.

Introduction: While cross-sectional studies have shown neural changes in long-term meditators, they might be confounded by self-selection and potential baseline differences between meditators and non meditators. Prospective longitudinal studies of the effects of meditation in naïve subjects are more conclusive with respect to causal inferences, but related evidence is so far limited.

Methods: Here, we assessed the effects of a 4-week Sahaja Yoga meditation training on gray matter density and spontaneous resting-state brain activity in a group of 12 meditation-naïve healthy adults. Read More

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November 2018

Silence from healthcare CEOs on AHCA politics is deafening.

Mod Healthc 2017 May;47(22)

Healthcare CEOs are hiding behind industry lobbying groups instead of publicly using their power to push for changes in the Republicans' healthcare reform bill. Read More

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Theoretical Investigation of Transcriptional Bursting: A Multi-State Approach.

J Phys Chem B 2018 Nov 27. Epub 2018 Nov 27.

Variability in gene expression causes genetically identical cells to exhibit different phenotypes. One probable cause of this variability is transcriptional bursting, where the synthesis of RNA molecules randomly alternates with periods of silence in the transfer of genetic information. Yet, the molecular mechanisms behind this variability remain unclear. Read More

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November 2018

c-Met inhibition is required for the celecoxib-attenuated stemness property of human colorectal cancer cells.

J Cell Physiol 2018 Nov 27. Epub 2018 Nov 27.

Department of Pharmacy, E-Da Cancer Hospital, Kaohsiung, Taiwan, ROC.

Cyclooxygenase-2 (COX-2) is frequently overexpressed and enhances colorectal cancer (CRC) tumorigenesis, including cancer stem cell (CSC) regulation. Accordingly, nonsteroidal anti-inflammatory drugs (NSAIDs), inhibiting COX-1/2 activity, are viewed as potential drugs for CRC treatment. Accumulated evidence indicates that celecoxib has the most potency for antitumor growth among NSAIDs and the underlying mechanism is only partly dependent on COX-2 inhibition. Read More

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November 2018
1 Read

Solid Phase Synthesis and Self-Assembly of Higher-Order siRNAs and their Bioconjugates.

Chem Biol Drug Des 2018 Nov 27. Epub 2018 Nov 27.

Department of Chemistry and Biochemistry, Seton Hall University, South Orange, NJ, 07079.

New methods for the synthesis of higher-order siRNA motifs and their bioconjugates have recently gained widespread attention in the development of new and improved gene therapeutics. Our efforts aim to produce new chemical tools and protocols for the generation of modified siRNAs that screen for important oncogene targets as well as silence their activity for effective gene therapy in cancer models. More specifically, we have developed an efficient solution-phase synthesis for the production of a ribouridine branchpoint synthon that can be effectively incorporated by solid phase synthesis within higher-order RNA structures, including those adopting V-, and Y- and >-< shape RNA templates. Read More

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November 2018
1 Read

Efficient PD-L1 gene silence promoted by hyaluronidase for cancer immunotherapy.

J Control Release 2018 Nov 23;293:104-112. Epub 2018 Nov 23.

Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China.

The immune checkpoint blockade of programmed death ligand-1 (PD-L1) or programmed death-1 (PD-1) has been a promising strategy to restore T cell mediated tumor suppression. In this study, a plasmid DNA which expressed small hairpin RNA of PD-L1 (shPD-L1) was loaded in the ultrasensitive pH triggered charge/size dual-rebound P[(GP)D] nanoparticles (NPs) to silence the PD-L1 gene for reducing the PD-L1/PD-1 interactions between tumors and T cells. To increase the penetration of the shPD-L1 loaded P[(GP)D] NPs (shPD-L1@NPs) in tumors, hyaluronidase (HAase) was utilized to degrade the overexpressed hyaluronicacid (HA) in the extracellular matrix (ECM) of the tumor tissues. Read More

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November 2018

piRNA-Guided Genome Defense: From Biogenesis to Silencing.

Annu Rev Genet 2018 Nov;52:131-157

Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, United Kingdom; email: ,

PIWI-interacting RNAs (piRNAs) and their associated PIWI clade Argonaute proteins constitute the core of the piRNA pathway. In gonadal cells, this conserved pathway is crucial for genome defense, and its main function is to silence transposable elements. This is achieved through posttranscriptional and transcriptional gene silencing. Read More

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November 2018

Silence is golden: A mixed methods investigation of silence in one case of psychodynamic psychotherapy.

Psychotherapy (Chic) 2018 Nov 26. Epub 2018 Nov 26.

Department of Counseling, Higher Education, and Special Education.

We investigated the antecedents, occurrences, and consequences of 183 silence events in the first 5 and last 5 sessions of a 73-session case of successful psychodynamic psychotherapy. Silences generally occurred within client speaking turns, such that the client often paused to reflect while speaking. In the last 5 sessions, as compared with the first 5 sessions, the client was more collaborative before and after silences, silences were shorter, the therapist was more connectional during silences (e. Read More

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November 2018

Tanshinone IIA alleviates oxidative damage after spinal cord injury in vitro and in vivo through up-regulating miR-124.

Life Sci 2018 Nov 20. Epub 2018 Nov 20.

School of Public Health Jilin University, Changchun 130021, Jilin, China. Electronic address:

Aims: Spinal cord injury (SCI) is a damage of spinal cord caused by trauma or diseases. Here, we explored the effects of tanshinone IIA (Tan IIA) on SCI oxidative damage in vitro and in vivo.

Materials And Methods: In vitro, PC-12 cells were treated by HO to stimulate oxidative injury. Read More

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November 2018
3 Reads
2.702 Impact Factor

After the war is over: the role of General Sir Arthur Currie in the development of academic medicine in Canada

Can J Surg 2018 Dec;61(6):367-369

From Western University, London, Ont. (Hyatt, McAlister); McGill University, Montreal, Que. (Beckett); and the Royal Canadian Medical Services, (Beckett, McAlister).

Summary: Canadian universities faced a challenge with the return of a large cohort of battle-hardened students and faculty from the First World War. General Sir Arthur Currie, considered one of the few successful generals of the war, returned to a welcome of silence in Canada. McGill University exploited the opportunity to recruit him as its president. Read More

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December 2018

Should clinicians boycott Australian immigration detention?

Authors:
Ryan Essex

J Med Ethics 2018 Nov 21. Epub 2018 Nov 21.

Australian immigration detention has been called state sanctioned abuse, cruel and degrading and likened to torture. Clinicians have long worked both within the system providing healthcare and outside of it advocating for broader social and political change. It has now been over 25 years and little, if anything, has changed. Read More

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November 2018
2 Reads

EPCAM mutation update: Variants associated with congenital tufting enteropathy and Lynch syndrome.

Hum Mutat 2018 Nov 21. Epub 2018 Nov 21.

Department of Pediatrics, University of California, San Diego, La Jolla, California.

The epithelial cell adhesion molecule gene (EPCAM, previously known as TACSTD1 or TROP1) encodes a membrane-bound protein that is localized to the basolateral membrane of epithelial cells and is overexpressed in some tumors. Biallelic mutations in EPCAM cause congenital tufting enteropathy (CTE), which is a rare chronic diarrheal disorder presenting in infancy. Monoallelic deletions of the 3' end of EPCAM that silence the downstream gene, MSH2, cause a form of Lynch syndrome, which is a cancer predisposition syndrome associated with loss of DNA mismatch repair. Read More

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November 2018
3 Reads

"I Thought I Was Dying:" (Un)Supportive Communication Surrounding Early Menstruation Experiences.

Health Commun 2018 Nov 21:1-11. Epub 2018 Nov 21.

c Department of Communication Studies , California State University.

Menstruation is a salient, and sometimes scary, communication topic for young women. The present study reports on the early communication experiences about menstruation from 165 women using open-ended survey data. Through the framework of supportive communication, findings reveal that a discrepancy occurs between the health and practical information and needs to which young people who menstruate desire access, and their social and emotional needs. Read More

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November 2018
1 Read

Is the Capacity for Vocal Learning in Vertebrates Rooted in Fish Schooling Behavior?

Evol Biol 2018 13;45(4):359-373. Epub 2018 Jun 13.

4Department of Plant and Wildlife Sciences, Brigham Young University, Provo, USA.

The capacity to learn and reproduce vocal sounds has evolved in phylogenetically distant tetrapod lineages. Vocal learners in all these lineages express similar neural circuitry and genetic factors when perceiving, processing, and reproducing vocalization, suggesting that brain pathways for vocal learning evolved within strong constraints from a common ancestor, potentially fish. We hypothesize that the auditory-motor circuits and genes involved in entrainment have their origins in fish schooling behavior and respiratory-motor coupling. Read More

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June 2018
2 Reads

Solving the Silence.

JAMA 2018 Nov;320(19):1979-1980

Department of Physical Medicine and Rehabilitation, University of Michigan, Ann Arbor.

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November 2018
3 Reads

Leucine-Rich Alpha-2-Glycoprotein1 Gene Interferes with Regulation of Apoptosis in Leukemia KASUMI-1 Cells.

Med Sci Monit 2018 Nov 20;24:8348-8356. Epub 2018 Nov 20.

Department of Hematology, Guizhou Provincial People's Hospital, Guiyang, Guizhou, China (mainland).

BACKGROUND Leukemia cells have strong proliferation and anti-apoptosis capabilities. The purpose of this study was to investigate the effect of silencing the leucine-rich alpha-2-glycoprotein1 (LRG1) gene, which was found to regulate tumor proliferation and apoptosis in acute myeloid leukemia (AML) cell lines. MATERIAL AND METHODS Plasmid interference technique was used to silence the LRG1 gene in the KASUMI-1 cell line. Read More

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November 2018
3 Reads

MFAP5 suppression inhibits migration/invasion, regulates cell cycle and induces apoptosis via promoting ROS production in cervical cancer.

Biochem Biophys Res Commun 2018 Dec 16;507(1-4):51-58. Epub 2018 Nov 16.

Department of Gynecology, Hanzhong Central Hospital, No.22, Kangfu Road, Hantai District, Hanzhomg, 723000, China. Electronic address:

Cervical cancer is one of the most lethal types of cancer among female. Microfibrillar-associated protein 5 (MFAP5) is an extracellular matrix (ECM) glycoprotein, and is confirmed to be involved in cell signaling during microfibril assembly, elastinogenesis and cell survival. However, the role of MFAP5 in cervical cancer development and progression remains poorly understood. Read More

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December 2018
4 Reads

AURKA contributes to the progression of oral squamous cell carcinoma (OSCC) through modulating epithelial-to-mesenchymal transition (EMT) and apoptosis via the regulation of ROS.

Biochem Biophys Res Commun 2018 Dec 16;507(1-4):83-90. Epub 2018 Nov 16.

Department of Oral and Maxillofacial Surgery, Gansu Provincial People's Hospital, Lanzhou, 730000, China. Electronic address:

Oral squamous cell carcinoma (OSCC) is known as one of the most common cancer influencing the head and neck region. However, the molecular mechanisms revealing OSCC progression is largely unclear. Aurora kinase A (AURKA) is a serine-threonine kinase that functions in mitotic spindle formation and chromosome segregation, and is associated with the progression of human cancers. Read More

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December 2018

Involvement of follistatin-like 3 in preeclampsia.

Biochem Biophys Res Commun 2018 Nov 27;506(3):692-697. Epub 2018 Oct 27.

Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, China; Key Laboratory of Women's Reproductive Health of Zhejiang Province, Hangzhou, China; Key Laboratory of Reproductive Genetics of the Ministry of Education, Hangzhou, China. Electronic address:

Introduction: Preeclampsia is a main cause of maternal and perinatal mortality and morbidity. The expression of follistatin-like 3 (FSTL3) is enhanced in maternal serum and placenta of preeclamptic women. However, whether FSTL3 is involved in the pathophysiologic of preeclampsia has not been clarified yet. Read More

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November 2018
2 Reads

Leukocytic toll-like receptor 2 knockout protects against diabetes-induced cardiac dysfunction.

Biochem Biophys Res Commun 2018 Nov 26;506(3):668-673. Epub 2018 Oct 26.

Department of Cardiology, Affiliated Hospital of North Sichuan Medical College, Nanchong City, 637000, Sichuan Province, PR China.

Diabetic cardiomyopathy is characterized by the deterioration of the myocardial function. Emerging evidences have indicated that leukocytic toll-like receptor 2 (TLR2) played an important role in the development of diabetic cardiomyopathy. Our study aimed to investigate whether TLR2 knockout (KO) exerted a cardioprotective effect in vivo. Read More

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November 2018
1 Read

Socially skilling toil: New artisanship in papermaking in late Chosŏn Korea.

Authors:
Jung Lee

Hist Sci 2018 Nov 20:73275318804692. Epub 2018 Nov 20.

Assistant Professor, Ewha Institute for the Humanities, Ewha Womans University, South Korea.

In pre-modern Korea, paper was renowned for its white glossy surface and cloth-like strength, becoming an important item in both tributary exchanges and private trade. The unique material of the tak tree and related technical innovations, including toch'im, the repeated beating of just-produced paper that provides sizing and fulling effects, were crucial to this fame. However, the scholar-officials who integrated papermaking into the state production system in order to meet administrative and tributary needs initially made toch'im corvée and then penal labor, thereby dismissing it as simple toil. Read More

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November 2018

Long non-coding RNA LINC00978 promotes cell proliferation and tumorigenesis via regulating microRNA-497/NTRK3 axis in gastric cancer.

Int J Biol Macromol 2018 Nov 17;123:1106-1114. Epub 2018 Nov 17.

Department of Gastrointestinal Surgery, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, Guangdong 519000, China. Electronic address:

Gastric cancer (GC) is the most common gastrointestinal malignancy in the digestive system. Recent studies have proven that long non-coding RNAs (lncRNAs) are closely related to tumor growth and metastasis. The study aimed to explore the effect of LINC00978 on GC cells proliferation and tumorigenesis. Read More

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November 2018
1 Read

RNAi modulation of placental sFLT1 for the treatment of preeclampsia.

Nat Biotechnol 2018 Nov 19. Epub 2018 Nov 19.

RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, Massachusetts, USA.

Preeclampsia is a placentally induced hypertensive disorder of pregnancy that is associated with substantial morbidity and mortality to mothers and fetuses. Clinical manifestations of preterm preeclampsia result from excess circulating soluble vascular endothelial growth factor receptor FLT1 (sFLT1 or sVEGFR1) of placental origin. Here we identify short interfering RNAs (siRNAs) that selectively silence the three sFLT1 mRNA isoforms primarily responsible for placental overexpression of sFLT1 without reducing levels of full-length FLT1 mRNA. Read More

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November 2018
21 Reads

Knockdown of long noncoding RNA GAS5 attenuates H O -induced damage in retinal ganglion cells through upregulating miR-124: Potential role in traumatic brain injury.

J Cell Biochem 2018 Nov 18. Epub 2018 Nov 18.

Department of Ophthalmology, Jining No. 1 People's Hospital, Jining, Shandong, China.

Background: Optic nerve injury is one of the most common and serious complications in traumatic brain injury (TBI). Alleviating degree of optic nerve injury is important to cure of TBI. This study explored the role of long noncoding RNA (lncRNA) GAS5 in mice retinal ganglion cells (RGCs) suffered to H O injury. Read More

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November 2018

Down-regulation of miR-200b-targeting Slug axis by cyclosporine A in human gingival fibroblasts.

J Formos Med Assoc 2018 Nov 16. Epub 2018 Nov 16.

Division of Periodontics, Department of Dentistry, Chi Mei Medical Center, Tainan, Taiwan; Min-Hwei Junior College of Health Care Management, Tainan, Taiwan. Electronic address:

Background/purpose: Cyclosporine A (CsA) has been used as an immunosuppressive agent with a side effect of gingival overgrowth. It has been known that CsA-induced epithelial-mesenchymal transition (EMT) in gingiva, but the molecular mechanism has not been fully unveiled. The purpose of the study is to investigate functional roles of microRNAs in gingival overgrowth. Read More

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November 2018
1 Read

Ending the Silence for Second Victims in Health Care.

Authors:
Jacqueline Ross

J Perianesth Nurs 2018 Dec;33(6):993-995

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December 2018

Making meaning of financial scarcity in old age.

J Aging Stud 2018 Dec 13;47:114-122. Epub 2018 Nov 13.

Department of Food and Resource Economics, University of Copenhagen, Denmark.

The purpose of this paper is twofold: first, we explore how older people (aged 69 to 85 years) living on the edge of relative poverty experience their everyday lives, and second, we investigate how they cope with their financial situation. We examine these aspects through 16 life story interviews to understand which paths these older people believe have led them to where they are today. First, we show how the older people highlight events or decisions in their life that mainly have an individual origin placing the responsibility of their current financial situation on themselves. Read More

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December 2018
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Dose-dependent effects of isoflurane on TrkB and GSK3β signaling: Importance of burst suppression pattern.

Neurosci Lett 2018 Nov 15;694:29-33. Epub 2018 Nov 15.

Laboratory of Neurotherapeutics, Molecular and Integrative Biosciences Research Programme, Faculty of Biological and Environmental Sciences, and Division of Pharmacology and Pharmacotherapeutics, Faculty of Pharmacy, University of Helsinki, Finland. Electronic address:

Objectives: Deep burst-suppressing isoflurane anesthesia regulates signaling pathways connected with antidepressant responses in the rodent brain: activation of TrkB neurotrophin receptor and inhibition of GSK3β kinase (glycogen synthase kinase 3β). The main objective of this study was to investigate whether EEG (electroencephalogram) burst suppression correlates with these intriguing molecular alterations induced by isoflurane.

Methods: Adult male mice pre-implanted with EEG recording electrodes were subjected to varying concentrations of isoflurane (1. Read More

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November 2018
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