172 results match your criteria Sign of Leser-Trelat


The sign of leser-trélat: think in the adenocarcinoma of the lung.

Pan Afr Med J 2018 10;30:270. Epub 2018 Aug 10.

Pulmonology Department, Moulay Youssef Hospital, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, Morocco.

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http://dx.doi.org/10.11604/pamj.2018.30.270.16337DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317404PMC

The Sign of Leser-Trelát and Malignant Acanthosis Nigricans Associated With Fallopian Tube Carcinoma.

Obstet Gynecol 2018 Nov;132(5):1116-1119

Departments of Dermatology and Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, and the Department of Dermatology, University of Texas Health Science Center at San Antonio, San Antonio, Texas.

Background: The sign of Leser-Trelát is controversial and rarely reported in gynecologic malignancies. It is characterized by rapid development of new or enlarging seborrheic keratoses.

Case: A 78-year-old woman presented with unintentional weight loss and new-onset erythematous patches and plaques with thickened, rugated skin and stuck-on brown waxy papules on the chest and back. Read More

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http://Insights.ovid.com/crossref?an=00006250-900000000-9791
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http://dx.doi.org/10.1097/AOG.0000000000002920DOI Listing
November 2018
7 Reads

Leser-Trélat Sign Presenting in a Patient with Relapsing Mycosis Fungoides.

Case Rep Oncol 2018 May-Aug;11(2):436-441. Epub 2018 Jun 29.

Pathology Department, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

The Leser-Trélat sign is a rare sign of some malignant tumors and is characterized by the sudden appearance of seborrheic keratosis in association with an underlying malignancy. We describe a 60-year-old Saudi man with mycosis fungoides (MF) who developed numerous, rapidly growing, seborrheic keratoses on his face and back. To the best of our knowledge, this is the first reported case of MF with the Leser-Trélat sign from Saudi Arabia. Read More

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http://dx.doi.org/10.1159/000490527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062719PMC
June 2018
3 Reads

Sign of Leser-Trélat and Cutaneous T-Cell Lymphoma: A Rare Association.

Dermatopathology (Basel) 2018 Apr-Jun;5(2):69-73. Epub 2018 May 25.

Department of Dermatology, University Hospital of Geneva, Geneva, Switzerland.

Sign of Leser-Trélat is a rare paraneoplastic cutaneous manifestation, characterized by the sudden appearance and rapid increase in size and number of seborrheic keratoses, accompanied by pruritus. Edmund Leser and Ulysse Trélat described this sign in 1890. Since their first description, their conclusions have been considered controversial and some authors assert the absence of a causal link. Read More

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http://dx.doi.org/10.1159/000488982DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031949PMC
May 2018
12 Reads

Leser-Trélat Syndrome in a Male with Breast Carcinoma and Eyelid Basal Cell Carcinoma.

Ocul Oncol Pathol 2018 Apr 4;4(3):161-164. Epub 2017 Nov 4.

Department of Pathology, Lady Hardinge Medical College and Associated S.S.K.H & K.S. Hospital, University of Delhi, New Delhi, India.

Purpose: Leser-Trélat syndrome consists of appearance of a solid tumor-like carcinoma breast, colon, or stomach following eruption of multiple seborrheic keratoses (SK) of the skin. We present an unusual and possibly the first case report of Leser-Trélat syndrome in a male patient with a history of mastectomy for breast carcinoma who presented to us with a second malignancy in the form of basal cell carcinoma (BCC) of the lower eyelid.

Procedure: A 75-year-old male presented in 2014 with a history of modified radical mastectomy for infiltrating ductal carcinoma of the left breast which was performed 11 years prior to the day of presentation. Read More

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http://dx.doi.org/10.1159/000481354DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5939681PMC
April 2018
6 Reads

The Leser-Trélat sign.

Cleve Clin J Med 2017 Dec;84(12):918

Department of Internal Medicine, University of California Davis, Sacramento, CA, USA.

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http://dx.doi.org/10.3949/ccjm.84a.17021DOI Listing
December 2017
12 Reads

Leser-Trélat Sign Secondary to Thymic Carcinoma.

Arch Bronconeumol 2018 May 3;54(5):286-287. Epub 2017 Nov 3.

Department of Radiology, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03002896173032
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http://dx.doi.org/10.1016/j.arbres.2017.08.020DOI Listing
May 2018
9 Reads

Eruptive Seborrheic Keratoses Restricted to Plaque/Patch-Stage Mycosis Fungoides.

Case Rep Dermatol 2017 May-Aug;9(2):35-39. Epub 2017 Jun 8.

Department of Dermatology, CHU Sart Tilman, University of Liège, Liège, Belgium.

Eruptive seborrheic keratoses (ESK) are rare in dermatology. They are usually inflammatory in nature and may be encountered as Leser-Trélat sign. ESK may also be simultaneously observed with hepatic angiomas, chemotherapy, segmental neurofibromatosis, HIV or erythrodermic pityriasis rubra pilaris, psoriasis, and drug eruption. Read More

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http://dx.doi.org/10.1159/000471787DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5498969PMC
June 2017
9 Reads

Cutaneous T-cell lymphoma-associated Leser-Trélat sign: report and world literature review.

Dermatol Online J 2017 Jan 15;23(1). Epub 2017 Jan 15.

School of Medicine, University of California San Diego.

Background: The sign of Leser-Trélat is characterizedby the sudden appearance of seborrheic keratosesassociated with an underlying malignancy.

Objectives: An elderly man who developed multiple new-onsetseborrheic keratoses temporally associated witha diagnosis of mycosis fungoides is described andlymphoma-associated Leser-Trélat sign is reviewed.

Methods: Pubmed was used to search the followingterms: cutaneous T-cell lymphoma, Leser-Trélat,leukemia, lymphoma, mycosis fungoides, and Sézarysyndrome. Read More

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January 2017
19 Reads

Seborrheic Keratoses as the First Sign of Bladder Carcinoma: Case Report of Leser-Trélat Sign in a Rare Association with Urinary Tract Cancer.

Case Rep Med 2016 23;2016:4259190. Epub 2016 Nov 23.

Internal Medicine Department, Clinics Hospital of the Federal University of Paraná, Curitiba, PR, Brazil.

. Skin disorders can be the first manifestation of occult diseases. The recognition of typical paraneoplastic dermatoses may anticipate the cancer diagnosis and improve its prognosis. Read More

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http://dx.doi.org/10.1155/2016/4259190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5141323PMC
November 2016
11 Reads

Leser-Trélat Sign in Tumor-Stage Mycosis Fungoides.

Dermatol Online J 2016 Apr 18;22(4). Epub 2016 Apr 18.

Department of Dermatology and Itch Center, Temple University School of Medicine.

A 71-year-old man presented with numerous pruritic seborrheic keratoses, with an eruptive onset over the course of 3 months. At presentation, he was also found to have hypopigmented tumors diffusely scattered throughout his body that were found to be mycosis fungoides on histologic examination. A theory regarding the pathophysiology of the development of eruptive seborrheic keratoses in the presence of mycosis fungoides is briefly discussed and 10 previous case reports of the Leser-Trélat sign in the setting of mycosis fungoides are reviewed. Read More

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April 2016
7 Reads

Cutaneous manifestations of lung cancer.

Semin Oncol 2016 06 23;43(3):366-9. Epub 2016 Feb 23.

University of Louisville, Division of Dermatology, Louisville, KY. Electronic address:

Skin findings can serve as a clue to internal disease. In this article, cutaneous manifestations of underlying lung malignancy are reviewed. Paraneoplastic dermatoses are rare, but when recognized early, can lead to early diagnosis of an underlying neoplasm. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00937754160005
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http://dx.doi.org/10.1053/j.seminoncol.2016.02.025DOI Listing
June 2016
9 Reads

Seborrheic keratoses and severe hypoinsulinemic hypoglycemia associated with insulin grow factor 2 secretion by a malignant solitary fibrous tumor.

Diabetol Metab Syndr 2016 29;8:33. Epub 2016 Apr 29.

Endocrinology Division, Escola Paulista de Medicina, Federal University of São Paulo, São Paulo, SP Brazil.

A rare sign of some malignant tumors is a sudden eruption of multiple seborrheic keratoses called Leser-Trélat sign. Overproduction of insulin-like growth factor-2 (IGF2) or its precursor is the main mechanism related to non-islet cell tumor hypoglycemia. Doege-Potter syndrome is the name given to paraneoplastic hypoinsulinemic hypoglycemia in presence of a solitary fibrous tumor. Read More

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http://dx.doi.org/10.1186/s13098-016-0148-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850662PMC
May 2016
12 Reads

Sign of Leser-Trélat.

BMJ Case Rep 2016 Apr 8;2016. Epub 2016 Apr 8.

Department of General Medicine, Mackay Hospital and Health Service, Mackay, Queensland, Australia.

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http://dx.doi.org/10.1136/bcr-2016-215316DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4840590PMC
April 2016
12 Reads

[Leser-Trelat sign associated with pancreatic cancer].

Med Clin (Barc) 2016 May 28;146(10):470. Epub 2016 Jan 28.

Equipo de Cuidados Paliativos de Badajoz, Programa Regional de Cuidados Paliativos de Extremadura, Badajoz, España. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00257753150062
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http://dx.doi.org/10.1016/j.medcli.2015.10.029DOI Listing
May 2016
5 Reads

Sign of Leser-Trélat in association with laryngeal carcinoma.

Indian J Dermatol Venereol Leprol 2016 Jan-Feb;82(1):112

Department of Dermatology, Venereology and Leprology, Government Medical College, Kota, Rajasthan, India.

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http://dx.doi.org/10.4103/0378-6323.164222DOI Listing
October 2016
6 Reads

Distant skin metastases as primary presentation of gastric cancer.

J Community Support Oncol 2015 Apr;13(4):156-8

Hematology-Oncology Section, Department of Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.

Distant gastric metastasis to the skin is uncommonly a presenting symptom, although nonspecific paraneoplastic syndromes with dermatologic manifestation including diffuse seborrheic keratoses (Leser-Trelat sign), tripe palms, and acanthosis nigricans have been described in the literature. We report here the case of a 49-year-old woman with gastric adenocarcinoma who presented with cutaneous metastasis as an initial symptom. In our case, metastatic skin lesions responded significantly to EOX chemotherapy (epirubicin+oxaliplatin+capecitabine) despite progression of systemic disease. Read More

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http://dx.doi.org/10.12788/jcso.0127DOI Listing
April 2015
22 Reads

Leser-Trelat sign with primary hepatic carcinoma.

Indian J Dermatol Venereol Leprol 2015 May-Jun;81(3):320-1

Department of Dermatology, No. 1 Hospital of China Medical University, Shenyang, China.

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http://dx.doi.org/10.4103/0378-6323.154792DOI Listing
February 2016
42 Reads

Leser-Trélat sign: a paraneoplastic process?

Cutis 2014 Nov;94(5):E14-5

Senevler mah 6139, Sok Saygınkent sitesi C blok no 3, Sanliurfa, Turkey.

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November 2014
6 Reads

Co-occurrence of malignant acanthosis nigricans and the Leser-Trélat sign in a patient with hepatocellular carcinoma.

Int J Dermatol 2015 11;54(5):e146-8. Epub 2014 Jul 11.

Department of Dermatology, Laboratory Medicine and Pathology, Rochester, MN, USA.

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http://dx.doi.org/10.1111/ijd.12096DOI Listing
January 2016
12 Reads

Leser-Trélat sign.

J Am Osteopath Assoc 2014 Jul;114(7):593

From the Internal Medicine-Pediatrics Residency Program at the University of Missouri School of Medicine in Columbia.

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http://dx.doi.org/10.7556/jaoa.2014.119DOI Listing
July 2014
7 Reads

Clinical image in gastroenterology. The sign of Leser-Trélat associated with rectal carcinoma.

Rev Gastroenterol Mex 2014 Oct-Dec;79(4):294-5. Epub 2014 Jun 16.

Departamento de Cirugía de Colon y Recto y Departamento de Dermatología, Hospital Guadalupano de Celaya, Celaya Guanajuato, México.

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http://dx.doi.org/10.1016/j.rgmx.2014.05.002DOI Listing
October 2016
4 Reads

Sign of leser-trélat associated with esophageal squamous cell cancer.

Case Rep Oncol Med 2014 6;2014:825929. Epub 2014 Feb 6.

Department of Medicine, Bronx Lebanon Hospital Center, 1650 Selwyn Avenue, Suite No. 10C, Bronx, NY 10457, USA.

The sign of Leser-Trélat is a rare paraneoplastic phenomenon marked by accelerated onset of multiple seborrheic keratoses. The occurrence of the sign often points towards underlying visceral malignancies which in a majority are adenocarcinomas of the gastrointestinal tract. We report this case of a 65-year-old man who presented with sign of Leser-Trélat and was diagnosed with poorly differentiated squamous cell cancer of the esophagus. Read More

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http://dx.doi.org/10.1155/2014/825929DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3970331PMC
April 2014
6 Reads

A Leser-Trélat sign indicating multiple gastrointestinal neoplasia.

Acta Clin Belg 2013 Sep-Oct;68(5):391-2

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http://dx.doi.org/10.2143/ACB.3426DOI Listing
April 2014
2 Reads

Sign and pseudo-sign of Leser-Trelat.

J Drugs Dermatol 2014 Jan;13(1):14

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January 2014
4 Reads

Leser-Trélat sign: does it really exist?

Acta Dermatovenerol Croat 2013 ;21(2):123-7

Department of Dermatology, Faculty of Medicine, University of Harran, 63200-Sanliurfa, Turkey.

Leser-Trélat sign is a rare cutaneous disorder that manifests with sudden emergence of seborrheic keratoses and increase in their numbers and size within weeks or months. Its concurrence with many types of malignancies, especially adenocarcinoma and lymphoma, has been reported in the literature. In this case report, a patient having Leser-Trélat sign, without any detected malignancy in spite of detailed examination and 18 months of follow up, is presented. Read More

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June 2014
4 Reads

Eruptive seborrheic keratoses associated with adalimumab use.

J Dermatol Case Rep 2013 Jun 30;7(2):60-3. Epub 2013 Jun 30.

University of Washington School of Medicine, Seattle, WA, USA;

Background: Seborrheic keratoses are common, benign cutaneous growths, however in rare situations they can acutely erupt in large numbers. Eruptive seborrheic keratoses can be associated with internal malignancy (sign of Leser-Trelat), but may also appear in conjunction with inflammatory dermatoses and adverse drug reactions.

Main Observation: A 71-year-old Caucasian man presented with acute onset of a pruritic, burning papular erythematous rash on his chest, upper extremities and lower extremities after a routine adalimumab injection for rheumatoid arthritis. Read More

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http://dx.doi.org/10.3315/jdcr.2013.1139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3710681PMC
June 2013
5 Reads

[Leser-Trélat sign associated with gastric cancer: report of one case].

Rev Med Chil 2012 Dec;140(12):1585-8

Servicio Urgencias, Hospital Víctor Río Ruiz, Los Ángeles, Chile.

We report a 66-year-old male presenting with malaise, heartburn and pruritic seborrheic keratoses in both feet of sudden onset, suggesting a Leser-Trélat sign. An upper gastrointestinal endoscopy disclosed a gastric cancer. The patient was subjected to a total gastrectomy and during follow up, the skin lesions had disappeared. Read More

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http://dx.doi.org/10.4067/S0034-98872012001200010DOI Listing
December 2012
25 Reads

Acanthosis nigricans, tripe palms, and sign of Leser-Trélat in a patient with gastric adenocarcinoma: case report and literature review in China.

Int J Dermatol 2015 Mar 15;54(3):338-42. Epub 2013 May 15.

Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, 430022.

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http://dx.doi.org/10.1111/ijd.12034DOI Listing
March 2015
16 Reads

Dermatomyositis associated with gallbladder carcinoma: A case report.

World J Hepatol 2013 Apr;5(4):230-3

Qing-Feng Ni, Guo-Qing Liu, Li-Yong Pu, Liang-Liang Kong, Lian-Bao Kong, Department of Liver Transplantation Center, The First Affiliated Hospital of Nanjing Medical University, The National Institute of Living Donor Liver Transplantation, Nanjing 210029, Jiangsu Province, China.

Patients with gallbladder carcinoma can present with a variety of paraneoplastic syndromes, including Cushing's syndrome, hypercalcemia, acanthosis nigricans, bullous pemphigoid, dermatomyositis and the sign of Leser-Trélat. Surgical resection of the primary tumor results in resolution of these paraneoplastic syndromes. We present a 67-year old female with facial and cervical erythema who was initially diagnosed with dermatomyositis. Read More

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http://dx.doi.org/10.4254/wjh.v5.i4.230DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3648656PMC
April 2013
92 Reads

Sign and pseudo-sign of Leser-Trélat: case reports and a review of the literature.

J Drugs Dermatol 2013 May;12(5):e79-87

Georgetown University Hospital, Washington Hospital Center, Washington DC, USA.

Background: Leser-Trélat is distinguished by a rare paraneoplastic sign that is characterized by the sudden eruption of multiple seborrheic keratoses (SKs), associated with underlying internal malignancies. Similar non-malignancy-associated SK eruptions are referred to as the "pseudo-sign of Leser-Trélat" (PLT).

Objective: Two cases of rapid SK eruptions, one the sign of Leser-Trélat (SLT) and one PLT, are presented, and the literature on SLT and PLT is reviewed. Read More

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May 2013
62 Reads

Paraneoplastic cutaneous manifestations: concepts and updates.

An Bras Dermatol 2013 Jan-Feb;88(1):9-22

Catholic University of Brasília- UCB, Brasília, (DF), Brazil.

The skin often signals systemic changes. Some neoplastic diseases that affect internal organs may trigger several cutaneous manifestations. Although these dermatoses are relatively unusual, the recognition of some typical paraneoplastic dermatoses may lead to the early diagnosis of a neoplasm and determine a better prognosis. Read More

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http://www.scielo.br/pdf/abd/v88n1/0365-0596-abd-88-1-0009.p
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3699944PMC
December 2013
6 Reads

Hyperinsulinemia associated with acanthosis nigricans, finger pebbles, acrochordons, and the sign of Leser-Trélat.

Endocr Pract 2013 May-Jun;19(3):522-5

Northeast Ohio Medical University, Rootstown, Ohio, USA.

Objective: To review common skin manifestations associated with type 2 diabetes mellitus (DM), and to discuss a potential underlying mechanism for these manifestations.

Methods: A PubMed literature search was conducted for articles describing the skin manifestations associated with hyperinsulinemia and type 2 DM. A case presentation describes a morbidly obese patient with type 2 DM treated with metformin who developed acanthosis nigricans, finger pebbles, scores of skin tags (acrochordons), and the sign of Leser-Trélat (sudden onset shower of seborrheic keratoses) in the absence of internal malignancy. Read More

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http://journals.aace.com/doi/abs/10.4158/EP12192.RA
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http://dx.doi.org/10.4158/EP12192.RADOI Listing
February 2014
9 Reads

Cutaneous manifestations of gastrointestinal disease: part I.

J Am Acad Dermatol 2013 Feb;68(2):189.e1-21; quiz 210

Division of Dermatology, Department of Internal Medicine, Baylor University Medical Center, Dallas, Texas 75246, USA.

Cutaneous findings are not uncommonly a concomitant finding in patients afflicted with gastrointestinal (GI) diseases. The dermatologic manifestations may precede clinically evident GI disease. Part I of this 2-part CME review focuses on dermatologic findings as they relate to hereditary and nonhereditary polyposis disorders and paraneoplastic disorders. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01909622120117
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http://dx.doi.org/10.1016/j.jaad.2012.10.037DOI Listing
February 2013
6 Reads

Uterine leiomyosarcoma and Leser-Trélat sign.

Lancet 2013 Jan;381(9860):88

Department of Obstetrics and Gynaecology, Oncology and high risk pregnancies, Maternity Hospital Souissi, University teaching hospital Ibn Sina of Rabat, Rabat, Morocco.

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http://dx.doi.org/10.1016/S0140-6736(12)61805-4DOI Listing
January 2013
5 Reads

Chemotherapy-induced inflammatory seborrheic keratoses in a man with acute myeloid leukemia: a variant of Leser-Trélat sign?

Cutis 2012 Nov;90(5):235-6

Department of Dermatology, Harvard Medical School, Brigham and Women's Hospital, Boston, Massachusetts, USA.

Leser-Trélat sign is a controversial paraneoplastic phenomenon characterized by an eruption of seborrheic keratoses (SKs). We report a rare case of eruptive inflammatory SKs in a man undergoing induction chemotherapy for acute myeloid leukemia (AML). We also review the literature on Leser-Trélat sign. Read More

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November 2012
5 Reads

Leser-Trélat sign and breast cancer.

Lancet 2013 May 30;381(9878):1653. Epub 2012 Nov 30.

Department of Dermatology, Venereology and Allergology, University School of Medicine Essen-Duisburg, Essen, Germany.

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http://dx.doi.org/10.1016/S0140-6736(12)61257-4DOI Listing
May 2013
7 Reads

Seborrheic keratoses of florid eruption.

Case Rep Oncol 2012 Sep 25;5(3):576-9. Epub 2012 Oct 25.

Johns Hopkins University/Sinai Hospital of Baltimore, Department of Internal Medicine, Baltimore, Md., USA.

We report the case of a 79-year-old Caucasian man, who developed numerous pruritic seborrheic keratoses on his chest and back within one year. An underlying malignant disease was suspected. Upper and lower endoscopies were performed and the patient was diagnosed with adenocarcinoma of the ascending colon. Read More

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http://dx.doi.org/10.1159/000343939DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3506034PMC
September 2012
1 Read

Leser-Trélat sign presenting in a patient with recurrent pre-B-cell acute lymphocytic leukemia.

Cutis 2012 Jan;89(1):33-5

Naval Hospital, Jacksonville, Florida, USA.

The presence of multiple seborrheic keratoses appearing abruptly in association with an underlying malignancy is known as Leser-Trélat sign, a rare paraneoplastic cutaneous syndrome. Although this finding is most commonly associated with solid organ tumors, it also can be a clue for the presence of underlying hematologic malignancies. We present a unique case of Leser-Trélat sign in a 20-year-old man who experienced a relapse of pre-B-cell acute lymphocytic leukemia (ALL) that was previously treated with multiple courses of chemotherapy and external radiation therapy. Read More

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January 2012
10 Reads

Cutaneous paraneoplasia.

Clin Dermatol 2011 Sep-Oct;29(5):541-7

Sector of Dermatology and Post Graduation Course of Dermatology, University Hospital Clementino Fraga Filho andSchool of Medicine, Federal University of Rio de Janeiro, 22280-020 Rio de Janeiro, Brazil.

Paraneoplasias are frequently the first sign of a subjacent malignant tumor. Although relatively rare, they need to be recognized by dermatologists to make an early diagnosis and improve the prognosis related especially to the neoplasia. This contribution presents the morphologic aspects and the differential diagnosis of the main paraneoplasias, which include acanthosis nigricans, tripe palms, Leser-Trélat sign, acquired ichthyosis, acquired hypertrichosis lanuginosa, pityriasis rotunda, erythema gyratum repens, palmo-plantar keratoderma, Bazex syndrome, and dermatomyositis, hoping to contribute to the familiarity of dermatologists with the identification and early diagnosis of this group. Read More

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http://dx.doi.org/10.1016/j.clindermatol.2010.09.022DOI Listing
December 2011
11 Reads

Leser-Trélat Sign without Internal Malignancy.

Case Rep Oncol 2011 Mar 29;4(1):175-7. Epub 2011 Mar 29.

Department of Dermatology, Centre Hospitalier de Saint-Brieuc, Saint-Brieuc, France.

Leser-Trélat sign is characterized by the abrupt appearance of multiple seborrheic keratoses in association with underlying malignant disease. A case of Leser-Trélat sign in a 66-year-old healthy woman is presented. Evaluation and follow-up for the development of malignancy over a 2-year period failed to reveal any evidence of malignancy. Read More

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https://www.karger.com/Article/FullText/327363
Publisher Site
http://dx.doi.org/10.1159/000327363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3081649PMC
March 2011
6 Reads

The Leser-Trelat sign is a associated with acute myeloid leukemia.

Ann Hematol 2011 Mar 12;90(3):363. Epub 2010 Aug 12.

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http://dx.doi.org/10.1007/s00277-010-1041-yDOI Listing
March 2011
4 Reads

The sign of Leser-Trelat in colorectal adenocarcinoma.

Am Surg 2010 Mar;76(3):340-1

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March 2010
6 Reads

Leser-Trélat syndrome in patients affected by six multiple metachronous primitive cancers.

J Hematol Oncol 2010 Jan 11;3. Epub 2010 Jan 11.

Department of Oncology and Haematology, University of Modena and Reggio Emilia, Modena, Italy.

Leser-Trélat syndrome is characterized by the eruptive appearance of multiple seborrheic keratoses in association with underlying malignant disease. Usually, the sign of Leser-Trélat is associated with adenocarcinoma, most frequently of the colon, breast, or stomach, but also of the lung, kidney, liver, and pancreas. Herein, we present a case that we believe is the first report of the sign of Leser-Trélat in association with occult gastric adenocarcinoma and the anamnestic oncologic history of five other multiple primitive cancers. Read More

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http://jhoonline.biomedcentral.com/articles/10.1186/1756-872
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http://dx.doi.org/10.1186/1756-8722-3-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2820021PMC
January 2010
8 Reads

Sign of Leser-Trélat with an adenocarcinoma of the prostate: a case report.

Cases J 2009 Aug 26;2:8868. Epub 2009 Aug 26.

Service de Dermatologie, Universite Montpellier I, Hopital Saint-Eloi CHU de Montpellier, 80, Avenue Augustin Fliche, FR-34295 Montpellier Cedex 5, France.

Introduction: The sign of Leser-Trélat is defined by the sudden appearance and rapid increase in number and size of seborrheic keratoses, preceding or revealing a malignancy. Even though this sign remains controversial, it has been described during a wide range of malignancies, including mainly adenocarcinoma of the gastro-intestinal tract or the breast.

Case Presentation: We report the case of a 68-year-old man who experienced sudden increased in number of seborrheic keratoses within two years prior to a diagnosis of adenocarcinoma of the prostate. Read More

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http://dx.doi.org/10.4076/1757-1626-2-8868DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2769478PMC
August 2009
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Leser-Trélat sign presenting in a patient with ovarian cancer: a case report.

J Med Case Rep 2009 Jul 23;3:8583. Epub 2009 Jul 23.

Introduction: Seborrheic keratoses are very common findings in elderly patients. However, a sudden onset and dramatic increase in the number and size of these benign lesions deserves special attention, since this may represent the Leser Trélat sign, a rare paraneoplastic cutaneous syndrome.

Case Presentation: A 92-year-old female presented to our clinic with multiple eruptive seborrheic keratoses, which had dramatically increased in size and number over the past two years. Read More

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http://dx.doi.org/10.4076/1752-1947-3-8583DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2737766PMC
July 2009
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