The Leser-Trélat sign.
- Authors:
- Christopher Sardon,
- Timothy Dempsey
Cleve Clin J Med 2017 Dec;84(12):918
Department of Internal Medicine, University of California Davis, Sacramento, CA, USA.
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Leser-Trélat Sign Secondary to Thymic Carcinoma.
- Authors:
- Gustavo Braga Mendes,
- Gláucia Zanetti,
- Edson Marchiori
Arch Bronconeumol 2017 Nov 2. Epub 2017 Nov 2.
Department of Radiology, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. Electronic address:
Eruptive Seborrheic Keratoses Restricted to Plaque/Patch-Stage Mycosis Fungoides.
- Authors:
- Eve Lebas,
- Pascale Quatresooz,
- Jorge E Arrese,
- Arjen F Nikkels
Case Rep Dermatol 2017 May-Aug;9(2):35-39. Epub 2017 Jun 8.
Department of Dermatology, CHU Sart Tilman, University of Liège, Liège, Belgium.
Eruptive seborrheic keratoses (ESK) are rare in dermatology. They are usually inflammatory in nature and may be encountered as Leser-Trélat sign. ESK may also be simultaneously observed with hepatic angiomas, chemotherapy, segmental neurofibromatosis, HIV or erythrodermic pityriasis rubra pilaris, psoriasis, and drug eruption. Read More
Cutaneous T-cell lymphoma-associated Leser-Trélat sign: report and world literature review.
- Authors:
- Saisindhu Narala,
- Philip R Cohen
Dermatol Online J 2017 Jan 15;23(1). Epub 2017 Jan 15.
School of Medicine, University of California San Diego.
Background: The sign of Leser-Trélat is characterizedby the sudden appearance of seborrheic keratosesassociated with an underlying malignancy.
Objectives: An elderly man who developed multiple new-onsetseborrheic keratoses temporally associated witha diagnosis of mycosis fungoides is described andlymphoma-associated Leser-Trélat sign is reviewed.
Methods: Pubmed was used to search the followingterms: cutaneous T-cell lymphoma, Leser-Trélat,leukemia, lymphoma, mycosis fungoides, and Sézarysyndrome. Read More
Objectives: An elderly man who developed multiple new-onsetseborrheic keratoses temporally associated witha diagnosis of mycosis fungoides is described andlymphoma-associated Leser-Trélat sign is reviewed.
Methods: Pubmed was used to search the followingterms: cutaneous T-cell lymphoma, Leser-Trélat,leukemia, lymphoma, mycosis fungoides, and Sézarysyndrome. Read More
Seborrheic Keratoses as the First Sign of Bladder Carcinoma: Case Report of Leser-Trélat Sign in a Rare Association with Urinary Tract Cancer.
- Authors:
- Aline Stollmeier,
- Bernardo Augusto Rosario,
- Bruna Loise Mayer,
- Gibran Avelino Frandoloso,
- Francisco Luiz Gomide Mafra Magalhães,
- Gustavo Lenci Marques
Case Rep Med 2016 23;2016:4259190. Epub 2016 Nov 23.
Internal Medicine Department, Clinics Hospital of the Federal University of Paraná, Curitiba, PR, Brazil.
. Skin disorders can be the first manifestation of occult diseases. The recognition of typical paraneoplastic dermatoses may anticipate the cancer diagnosis and improve its prognosis. Read More
Leser-Trélat Sign in Tumor-Stage Mycosis Fungoides.
- Authors:
- Brandon Rowe,
- Alina Shevchenko,
- Gil Yosipovitch
Dermatol Online J 2016 Apr 18;22(4). Epub 2016 Apr 18.
Department of Dermatology and Itch Center, Temple University School of Medicine.
A 71-year-old man presented with numerous pruritic seborrheic keratoses, with an eruptive onset over the course of 3 months. At presentation, he was also found to have hypopigmented tumors diffusely scattered throughout his body that were found to be mycosis fungoides on histologic examination. A theory regarding the pathophysiology of the development of eruptive seborrheic keratoses in the presence of mycosis fungoides is briefly discussed and 10 previous case reports of the Leser-Trélat sign in the setting of mycosis fungoides are reviewed. Read More
Cutaneous manifestations of lung cancer.
- Authors:
- Cindy England Owen
Semin Oncol 2016 06 23;43(3):366-9. Epub 2016 Feb 23.
University of Louisville, Division of Dermatology, Louisville, KY. Electronic address:
Skin findings can serve as a clue to internal disease. In this article, cutaneous manifestations of underlying lung malignancy are reviewed. Paraneoplastic dermatoses are rare, but when recognized early, can lead to early diagnosis of an underlying neoplasm. Read More
Seborrheic keratoses and severe hypoinsulinemic hypoglycemia associated with insulin grow factor 2 secretion by a malignant solitary fibrous tumor.
Diabetol Metab Syndr 2016 29;8:33. Epub 2016 Apr 29.
Endocrinology Division, Escola Paulista de Medicina, Federal University of São Paulo, São Paulo, SP Brazil.
A rare sign of some malignant tumors is a sudden eruption of multiple seborrheic keratoses called Leser-Trélat sign. Overproduction of insulin-like growth factor-2 (IGF2) or its precursor is the main mechanism related to non-islet cell tumor hypoglycemia. Doege-Potter syndrome is the name given to paraneoplastic hypoinsulinemic hypoglycemia in presence of a solitary fibrous tumor. Read More
Sign of Leser-Trélat.
- Authors:
- Katrina Chakradeo,
- Kaustubh Narsinghpura,
- Adel Ekladious
BMJ Case Rep 2016 Apr 8;2016. Epub 2016 Apr 8.
Department of General Medicine, Mackay Hospital and Health Service, Mackay, Queensland, Australia.
[Leser-Trelat sign associated with pancreatic cancer].
- Authors:
- Miguel Ángel Cuervo Pinna
Med Clin (Barc) 2016 May 28;146(10):470. Epub 2016 Jan 28.
Equipo de Cuidados Paliativos de Badajoz, Programa Regional de Cuidados Paliativos de Extremadura, Badajoz, España. Electronic address:
Sign of Leser-Trélat in association with laryngeal carcinoma.
- Authors:
- Asha Nyati,
- Sarita Kalwaniya,
- Suresh Jain,
- Bajrang Soni
Indian J Dermatol Venereol Leprol 2016 Jan-Feb;82(1):112
Department of Dermatology, Venereology and Leprology, Government Medical College, Kota, Rajasthan, India.
Distant skin metastases as primary presentation of gastric cancer.
- Authors:
- Bilal Ahmad,
- Namali Pierson,
- Mohammed Muqueet Adnan,
- Minh Phan,
- Justin Jenkins,
- Shubham Pant,
- Mohamad Cherry,
- Mohamad Khawandanah
J Community Support Oncol 2015 Apr;13(4):156-8
Hematology-Oncology Section, Department of Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
Distant gastric metastasis to the skin is uncommonly a presenting symptom, although nonspecific paraneoplastic syndromes with dermatologic manifestation including diffuse seborrheic keratoses (Leser-Trelat sign), tripe palms, and acanthosis nigricans have been described in the literature. We report here the case of a 49-year-old woman with gastric adenocarcinoma who presented with cutaneous metastasis as an initial symptom. In our case, metastatic skin lesions responded significantly to EOX chemotherapy (epirubicin+oxaliplatin+capecitabine) despite progression of systemic disease. Read More
Leser-Trelat sign with primary hepatic carcinoma.
- Authors:
- Jiu-Hong Li,
- Hao Guo,
- Bo Li,
- Xing-Hua Gao
Indian J Dermatol Venereol Leprol 2015 May-Jun;81(3):320-1
Department of Dermatology, No. 1 Hospital of China Medical University, Shenyang, China.
Leser-Trélat sign: a paraneoplastic process?
- Authors:
- Enver Turan,
- Mehmet Salih Gurel,
- Asli Turgut Erdemir
Cutis 2014 Nov;94(5):E14-5
Senevler mah 6139, Sok Saygınkent sitesi C blok no 3, Sanliurfa, Turkey.
Co-occurrence of malignant acanthosis nigricans and the Leser-Trélat sign in a patient with hepatocellular carcinoma.
- Authors:
- Oluwakemi Onajin,
- Nneka I Comfere
Int J Dermatol 2015 11;54(5):e146-8. Epub 2014 Jul 11.
Department of Dermatology, Laboratory Medicine and Pathology, Rochester, MN, USA.
Leser-Trélat sign.
- Authors:
- Eric M Neverman,
- Kevin Clary
J Am Osteopath Assoc 2014 Jul;114(7):593
From the Internal Medicine-Pediatrics Residency Program at the University of Missouri School of Medicine in Columbia.
Clinical image in gastroenterology. The sign of Leser-Trélat associated with rectal carcinoma.
Rev Gastroenterol Mex 2014 Oct-Dec;79(4):294-5. Epub 2014 Jun 16.
Departamento de Cirugía de Colon y Recto y Departamento de Dermatología, Hospital Guadalupano de Celaya, Celaya Guanajuato, México.
The sign of Leser-Trélat: is it really so?--for your eyes only.
- Authors:
- Michael Joseph Lavery,
- Lawrence Charles Parish,
- Peter C Lambert,
- Robert E Lee,
- W Clark Lambert
Skinmed 2014 Mar-Apr;12(2):76-8
Sign of leser-trélat associated with esophageal squamous cell cancer.
Case Rep Oncol Med 2014 6;2014:825929. Epub 2014 Feb 6.
Department of Medicine, Bronx Lebanon Hospital Center, 1650 Selwyn Avenue, Suite No. 10C, Bronx, NY 10457, USA.
The sign of Leser-Trélat is a rare paraneoplastic phenomenon marked by accelerated onset of multiple seborrheic keratoses. The occurrence of the sign often points towards underlying visceral malignancies which in a majority are adenocarcinomas of the gastrointestinal tract. We report this case of a 65-year-old man who presented with sign of Leser-Trélat and was diagnosed with poorly differentiated squamous cell cancer of the esophagus. Read More
A Leser-Trélat sign indicating multiple gastrointestinal neoplasia.
- Authors:
- C van Marcke,
- S Lejeune,
- L D'Hondt
Acta Clin Belg 2013 Sep-Oct;68(5):391-2
Sign and pseudo-sign of Leser-Trelat.
- Authors:
- Lutz Kowalzick,
- Beate Truhm,
- Lena Eickenscheidt
J Drugs Dermatol 2014 Jan;13(1):14
Leser-Trélat sign: does it really exist?
- Authors:
- Enver Turan,
- Yavuz Yesilova,
- Nurdan Yurt,
- Sezen Koçarslan
Acta Dermatovenerol Croat 2013 ;21(2):123-7
Department of Dermatology, Faculty of Medicine, University of Harran, 63200-Sanliurfa, Turkey.
Leser-Trélat sign is a rare cutaneous disorder that manifests with sudden emergence of seborrheic keratoses and increase in their numbers and size within weeks or months. Its concurrence with many types of malignancies, especially adenocarcinoma and lymphoma, has been reported in the literature. In this case report, a patient having Leser-Trélat sign, without any detected malignancy in spite of detailed examination and 18 months of follow up, is presented. Read More
Eruptive seborrheic keratoses associated with adalimumab use.
- Authors:
- Kristin L Eastman,
- Stevan R Knezevich,
- Gregory J Raugi
J Dermatol Case Rep 2013 Jun 30;7(2):60-3. Epub 2013 Jun 30.
University of Washington School of Medicine, Seattle, WA, USA;
Background: Seborrheic keratoses are common, benign cutaneous growths, however in rare situations they can acutely erupt in large numbers. Eruptive seborrheic keratoses can be associated with internal malignancy (sign of Leser-Trelat), but may also appear in conjunction with inflammatory dermatoses and adverse drug reactions.
Main Observation: A 71-year-old Caucasian man presented with acute onset of a pruritic, burning papular erythematous rash on his chest, upper extremities and lower extremities after a routine adalimumab injection for rheumatoid arthritis. Read More
Main Observation: A 71-year-old Caucasian man presented with acute onset of a pruritic, burning papular erythematous rash on his chest, upper extremities and lower extremities after a routine adalimumab injection for rheumatoid arthritis. Read More
[Leser-Trélat sign associated with gastric cancer: report of one case].
- Authors:
- Felipe A Venegas,
- Paula M Vaccaro,
- Gabriel A Abudinén,
- Carlos V Reydet,
- Francisco V Brunie,
- Javier D Arcuch
Rev Med Chil 2012 Dec;140(12):1585-8
Servicio Urgencias, Hospital Víctor Río Ruiz, Los Ángeles, Chile.
We report a 66-year-old male presenting with malaise, heartburn and pruritic seborrheic keratoses in both feet of sudden onset, suggesting a Leser-Trélat sign. An upper gastrointestinal endoscopy disclosed a gastric cancer. The patient was subjected to a total gastrectomy and during follow up, the skin lesions had disappeared. Read More
Acanthosis nigricans, tripe palms, and sign of Leser-Trélat in a patient with gastric adenocarcinoma: case report and literature review in China.
- Authors:
- Na Zhang,
- Yue Qian,
- Ai Ping Feng
Int J Dermatol 2015 Mar 15;54(3):338-42. Epub 2013 May 15.
Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, 430022.
Dermatomyositis associated with gallbladder carcinoma: A case report.
- Authors:
- Qing-Feng Ni,
- Guo-Qing Liu,
- Li-Yong Pu,
- Liang-Liang Kong,
- Lian-Bao Kong
World J Hepatol 2013 Apr;5(4):230-3
Qing-Feng Ni, Guo-Qing Liu, Li-Yong Pu, Liang-Liang Kong, Lian-Bao Kong, Department of Liver Transplantation Center, The First Affiliated Hospital of Nanjing Medical University, The National Institute of Living Donor Liver Transplantation, Nanjing 210029, Jiangsu Province, China.
Patients with gallbladder carcinoma can present with a variety of paraneoplastic syndromes, including Cushing's syndrome, hypercalcemia, acanthosis nigricans, bullous pemphigoid, dermatomyositis and the sign of Leser-Trélat. Surgical resection of the primary tumor results in resolution of these paraneoplastic syndromes. We present a 67-year old female with facial and cervical erythema who was initially diagnosed with dermatomyositis. Read More
Sign and pseudo-sign of Leser-Trélat: case reports and a review of the literature.
- Authors:
- Zain Husain,
- Joyce K Ho,
- Basil M Hantash
J Drugs Dermatol 2013 May;12(5):e79-87
Georgetown University Hospital, Washington Hospital Center, Washington DC, USA.
Background: Leser-Trélat is distinguished by a rare paraneoplastic sign that is characterized by the sudden eruption of multiple seborrheic keratoses (SKs), associated with underlying internal malignancies. Similar non-malignancy-associated SK eruptions are referred to as the "pseudo-sign of Leser-Trélat" (PLT).
Objective: Two cases of rapid SK eruptions, one the sign of Leser-Trélat (SLT) and one PLT, are presented, and the literature on SLT and PLT is reviewed. Read More
Objective: Two cases of rapid SK eruptions, one the sign of Leser-Trélat (SLT) and one PLT, are presented, and the literature on SLT and PLT is reviewed. Read More
Paraneoplastic cutaneous manifestations: concepts and updates.
- Authors:
- Josenilson Antônio da Silva,
- Kleyton de Carvalho Mesquita,
- Ana Carolina de Souza Machado Igreja,
- Isabella Cristina Rodrigues Naves Lucas,
- Aline Ferreira Freitas,
- Sandra Maximiano de Oliveira,
- Izelda Maria Carvalho Costa,
- Iphis Tenfuss Campbell
An Bras Dermatol 2013 Jan-Feb;88(1):9-22
Catholic University of Brasília- UCB, Brasília, (DF), Brazil.
The skin often signals systemic changes. Some neoplastic diseases that affect internal organs may trigger several cutaneous manifestations. Although these dermatoses are relatively unusual, the recognition of some typical paraneoplastic dermatoses may lead to the early diagnosis of a neoplasm and determine a better prognosis. Read More
Hyperinsulinemia associated with acanthosis nigricans, finger pebbles, acrochordons, and the sign of Leser-Trélat.
- Authors:
- Ami Saraiya,
- Ahmad Al-Shoha,
- Robert T Brodell
Endocr Pract 2013 May-Jun;19(3):522-5
Northeast Ohio Medical University, Rootstown, Ohio, USA.
Objective: To review common skin manifestations associated with type 2 diabetes mellitus (DM), and to discuss a potential underlying mechanism for these manifestations.
Methods: A PubMed literature search was conducted for articles describing the skin manifestations associated with hyperinsulinemia and type 2 DM. A case presentation describes a morbidly obese patient with type 2 DM treated with metformin who developed acanthosis nigricans, finger pebbles, scores of skin tags (acrochordons), and the sign of Leser-Trélat (sudden onset shower of seborrheic keratoses) in the absence of internal malignancy. Read More
Methods: A PubMed literature search was conducted for articles describing the skin manifestations associated with hyperinsulinemia and type 2 DM. A case presentation describes a morbidly obese patient with type 2 DM treated with metformin who developed acanthosis nigricans, finger pebbles, scores of skin tags (acrochordons), and the sign of Leser-Trélat (sudden onset shower of seborrheic keratoses) in the absence of internal malignancy. Read More
Cutaneous manifestations of gastrointestinal disease: part I.
- Authors:
- Kejal R Shah,
- C Richard Boland,
- Mahir Patel,
- Breck Thrash,
- Alan Menter
J Am Acad Dermatol 2013 Feb;68(2):189.e1-21; quiz 210
Division of Dermatology, Department of Internal Medicine, Baylor University Medical Center, Dallas, Texas 75246, USA.
Cutaneous findings are not uncommonly a concomitant finding in patients afflicted with gastrointestinal (GI) diseases. The dermatologic manifestations may precede clinically evident GI disease. Part I of this 2-part CME review focuses on dermatologic findings as they relate to hereditary and nonhereditary polyposis disorders and paraneoplastic disorders. Read More
Uterine leiomyosarcoma and Leser-Trélat sign.
- Authors:
- Sanae Abakka,
- Hatim Elhalouat,
- Nadia Khoummane,
- Mouad Achaaban,
- Sabah ElAmrani,
- Samir Bargach,
- Mounia Yousfi
Lancet 2013 Jan;381(9860):88
Department of Obstetrics and Gynaecology, Oncology and high risk pregnancies, Maternity Hospital Souissi, University teaching hospital Ibn Sina of Rabat, Rabat, Morocco.
Chemotherapy-induced inflammatory seborrheic keratoses in a man with acute myeloid leukemia: a variant of Leser-Trélat sign?
- Authors:
- Evelyn Lilly,
- Scott R Granter,
- Harley A Haynes,
- Omar A Ibrahimi
Cutis 2012 Nov;90(5):235-6
Department of Dermatology, Harvard Medical School, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Leser-Trélat sign is a controversial paraneoplastic phenomenon characterized by an eruption of seborrheic keratoses (SKs). We report a rare case of eruptive inflammatory SKs in a man undergoing induction chemotherapy for acute myeloid leukemia (AML). We also review the literature on Leser-Trélat sign. Read More
Leser-Trélat sign and breast cancer.
Lancet 2013 May 30;381(9878):1653. Epub 2012 Nov 30.
Department of Dermatology, Venereology and Allergology, University School of Medicine Essen-Duisburg, Essen, Germany.
Seborrheic keratoses of florid eruption.
- Authors:
- Helen Gharwan,
- Jeremy D Gradon
Case Rep Oncol 2012 Sep 25;5(3):576-9. Epub 2012 Oct 25.
Johns Hopkins University/Sinai Hospital of Baltimore, Department of Internal Medicine, Baltimore, Md., USA.
We report the case of a 79-year-old Caucasian man, who developed numerous pruritic seborrheic keratoses on his chest and back within one year. An underlying malignant disease was suspected. Upper and lower endoscopies were performed and the patient was diagnosed with adenocarcinoma of the ascending colon. Read More
Leser-Trélat sign presenting in a patient with recurrent pre-B-cell acute lymphocytic leukemia.
- Authors:
- Jerry J Fasoldt,
- Eric R Brumwell,
- Jeffrey N Lackey
Cutis 2012 Jan;89(1):33-5
Naval Hospital, Jacksonville, Florida, USA.
The presence of multiple seborrheic keratoses appearing abruptly in association with an underlying malignancy is known as Leser-Trélat sign, a rare paraneoplastic cutaneous syndrome. Although this finding is most commonly associated with solid organ tumors, it also can be a clue for the presence of underlying hematologic malignancies. We present a unique case of Leser-Trélat sign in a 20-year-old man who experienced a relapse of pre-B-cell acute lymphocytic leukemia (ALL) that was previously treated with multiple courses of chemotherapy and external radiation therapy. Read More
Cutaneous paraneoplasia.
Clin Dermatol 2011 Sep-Oct;29(5):541-7
Sector of Dermatology and Post Graduation Course of Dermatology, University Hospital Clementino Fraga Filho andSchool of Medicine, Federal University of Rio de Janeiro, 22280-020 Rio de Janeiro, Brazil.
Paraneoplasias are frequently the first sign of a subjacent malignant tumor. Although relatively rare, they need to be recognized by dermatologists to make an early diagnosis and improve the prognosis related especially to the neoplasia. This contribution presents the morphologic aspects and the differential diagnosis of the main paraneoplasias, which include acanthosis nigricans, tripe palms, Leser-Trélat sign, acquired ichthyosis, acquired hypertrichosis lanuginosa, pityriasis rotunda, erythema gyratum repens, palmo-plantar keratoderma, Bazex syndrome, and dermatomyositis, hoping to contribute to the familiarity of dermatologists with the identification and early diagnosis of this group. Read More
Leser-Trélat Sign without Internal Malignancy.
- Authors:
- Gilles Safa,
- Laure Darrieux
Case Rep Oncol 2011 Mar 29;4(1):175-7. Epub 2011 Mar 29.
Department of Dermatology, Centre Hospitalier de Saint-Brieuc, Saint-Brieuc, France.
Leser-Trélat sign is characterized by the abrupt appearance of multiple seborrheic keratoses in association with underlying malignant disease. A case of Leser-Trélat sign in a 66-year-old healthy woman is presented. Evaluation and follow-up for the development of malignancy over a 2-year period failed to reveal any evidence of malignancy. Read More
The Leser-Trelat sign is a associated with acute myeloid leukemia.
- Authors:
- Irfan Yavasoglu,
- Gurhan Kadikoylu,
- Zahit Bolaman
Ann Hematol 2011 Mar 12;90(3):363. Epub 2010 Aug 12.
The sign of Leser-Trelat in colorectal adenocarcinoma.
- Authors:
- Constantinos Constantinou,
- Horatiu Dancea,
- Paul Meade
Am Surg 2010 Mar;76(3):340-1
Leser-Trélat syndrome in patients affected by six multiple metachronous primitive cancers.
J Hematol Oncol 2010 Jan 11;3. Epub 2010 Jan 11.
Department of Oncology and Haematology, University of Modena and Reggio Emilia, Modena, Italy.
Leser-Trélat syndrome is characterized by the eruptive appearance of multiple seborrheic keratoses in association with underlying malignant disease. Usually, the sign of Leser-Trélat is associated with adenocarcinoma, most frequently of the colon, breast, or stomach, but also of the lung, kidney, liver, and pancreas. Herein, we present a case that we believe is the first report of the sign of Leser-Trélat in association with occult gastric adenocarcinoma and the anamnestic oncologic history of five other multiple primitive cancers. Read More
Sign of Leser-Trélat with an adenocarcinoma of the prostate: a case report.
- Authors:
- Nicolas Kluger,
- Bernard Guillot
Cases J 2009 Aug 26;2:8868. Epub 2009 Aug 26.
Service de Dermatologie, Universite Montpellier I, Hopital Saint-Eloi CHU de Montpellier, 80, Avenue Augustin Fliche, FR-34295 Montpellier Cedex 5, France.
Introduction: The sign of Leser-Trélat is defined by the sudden appearance and rapid increase in number and size of seborrheic keratoses, preceding or revealing a malignancy. Even though this sign remains controversial, it has been described during a wide range of malignancies, including mainly adenocarcinoma of the gastro-intestinal tract or the breast.
Case Presentation: We report the case of a 68-year-old man who experienced sudden increased in number of seborrheic keratoses within two years prior to a diagnosis of adenocarcinoma of the prostate. Read More
Case Presentation: We report the case of a 68-year-old man who experienced sudden increased in number of seborrheic keratoses within two years prior to a diagnosis of adenocarcinoma of the prostate. Read More
Leser-Trélat sign presenting in a patient with ovarian cancer: a case report.
- Authors:
- Edwin Bölke,
- Peter Arne Gerber,
- Matthias Peiper,
- Wolfram Trudo Knoefel,
- Mathias Cohnen,
- Christiane Matuschek,
- Wilfried Budach,
- Rainer Engers,
- Stephan Gripp
J Med Case Rep 2009 Jul 23;3:8583. Epub 2009 Jul 23.
Introduction: Seborrheic keratoses are very common findings in elderly patients. However, a sudden onset and dramatic increase in the number and size of these benign lesions deserves special attention, since this may represent the Leser Trélat sign, a rare paraneoplastic cutaneous syndrome.
Case Presentation: A 92-year-old female presented to our clinic with multiple eruptive seborrheic keratoses, which had dramatically increased in size and number over the past two years. Read More
Case Presentation: A 92-year-old female presented to our clinic with multiple eruptive seborrheic keratoses, which had dramatically increased in size and number over the past two years. Read More
Three simultaneous paraneoplastic manifestations (ichthyosis acquisita, Bazex syndrome, and Leser-Trélat sign) with prostate adenocarcinoma.
- Authors:
- Ana Cecília Michel da Rosa,
- Giselle Martins Pinto,
- Juliana Steckel Bortoluzzi,
- Rodrigo Pereira Duquia,
- Hiram Larangeira de Almeida
J Am Acad Dermatol 2009 Sep;61(3):538-40
False Leser-Trélat sign.
Int J Dermatol 2009 Aug;48(8):912-3
Skin spicules: A newly described paraneoplastic phenomenon associated with a marginal zone B-cell lymphoma.
- Authors:
- Stephanie Hu,
- Scott R Granter,
- Harley A Haynes,
- Danielle M Miller
J Am Acad Dermatol 2009 May;60(5):852-5
Harvard Medical School, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.
Paraneoplastic signs are an important clue to diagnosing an associated malignancy. We report an unusual variant of the sign of Leser-Trélat in a patient with a low-grade B-cell lymphoproliferative disorder and intertriginous skin spicules with histologic morphology of minute seborrheic keratoses. Read More
Seborrhoeic keratoses in patients with internal malignancies: a case-control study with prospective accrual of patients.
J Eur Acad Dermatol Venereol 2009 Nov 4;23(11):1316-9. Epub 2009 Mar 4.
Department of Dermatology, Wilhelminenspital, Vienna, Austria.
Background: The association between the eruption of numerous seborrhoeic keratoses as a result of an underlying malignancy is controversially discussed. The aim of this case-control study with prospective accrual of patients was to determine whether a direct association exists between the number seborrhoeic keratoses and internal malignancies.
Methods: The numbers and sites of seborrhoeic keratoses were counted in 150 oncological patients and 150 matched controls. Read More
Methods: The numbers and sites of seborrhoeic keratoses were counted in 150 oncological patients and 150 matched controls. Read More
Paraneoplastic sensory neuropathy associated with small cell carcinoma of the gallbladder.
Ann Diagn Pathol 2009 Apr 11;13(2):124-6. Epub 2008 Jan 11.
Department of Pathology, Instituto Nacional de Ciencias Medicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
A small number of patients with carcinoma of the gallbladder can present with a variety of paraneoplastic syndromes, including the Cushing syndrome, hypercalcemia, acanthosis nigricans, bullous pemphigoid, dermatomyositis, and the Leser-Trélat sign. We report on what appears to be the first case of a patient, a 48-year-old woman, with anti-Hu paraneoplastic sensory neuropathy and small cell carcinoma of the gallbladder. The patient's neurologic symptoms preceded the diagnosis of small cell carcinoma by 11 months. Read More
Bilateral Leser-Trélat sign mirroring lung adenocarcinoma with early metastases to the contralateral lung.
- Authors:
- Constantin A Dasanu,
- Doru T Alexandrescu
South Med J 2009 Feb;102(2):216-8
Georgetown University, Washington, DC, USA.
We present a case featuring a unique overlap between the body areas involved by lung adenocarcinoma and the cutaneous paraneoplastic sign of Leser-Trélat. In our patient, the Leser-Trélat sign consisted of explosive multiple seborrheic keratoses in combination with acanthosis nigricans, representing a remarkable geometric skin projection of lung cancer which involved both the upper lobes. Our case suggests a unique interrelation between the paraneoplastic sign of Leser-Trélat and the tumor itself. Read More
