Arch Biochem Biophys 2021 01 3;697:108661. Epub 2020 Nov 3.
The Ohio State University Biophysics Program, The Ohio State University, 484 West 12thAvenue, Columbus, OH, 43210, United States; Department of Chemistry and Biochemistry, The Ohio State University, 100 West 18th Avenue, Columbus, OH, 43210, United States. Electronic address: https://chemistry.osu.edu/people/cowan.2.
Iron-sulfur cluster proteins play key roles in a multitude of cellular processes. Iron-sulfur cofactors are assembled primarily in mitochondria and are then exported to the cytosol by use of an ABCB7 transporter. It has been shown that the yeast mitochondrial transporter Atm1 can export glutathione-coordinated iron-sulfur clusters, [2Fe-2S](SG), providing a source of cluster units for cytosolic iron-sulfur cluster assembly systems. Read More