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Curr Opin Clin Nutr Metab Care 2020 Jun 28. Epub 2020 Jun 28.

Department of Gastroenterology and Nutritional Support, Center for Intestinal Failure, Reference Centre of Rare Disease MarDI, AP-HP Beaujon Hospital, University of Paris Inserm UMR 1149, Paris, France.

Purpose Of Review: As the approval of teduglutide, a glucagon-like peptide-2 (GLP-2) analog, for the treatment of patients with short bowel syndrome (SBS) associated with intestinal failure, enterohormone therapy has received significant interest and is becoming the first choice of treatment in selected patients. As such, it is paramount to assess and understand the new place of hormonal therapy in the algorithm of treatments in SBS-intestinal failure.

Recent Findings: Specialized intestinal failure units have recently reported their outcomes with teduglutide to evaluate if they are consistent with the phase III trials results. Read More

Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2020 Jun;42(3):405-409

Department of Gastrointestinal Surgery,Beijing Tsinghua Changgung Hospital,School of Clinical Medicine, Tsinghua University,Beijing 102218,China.

Radioactive enteritis(RE)is one of the most serious and common complications of intestinal tract caused by radiotherapy for malignant tumors in abdominal cavity,pelvic cavity,or retroperitoneum.Involved intestinal diseases are widespread,complex,and persistent,which make treatment difficult and ineffective.Short bowel syndrome can develop in some serious cases. Read More

Ann Pediatr Endocrinol Metab 2020 Jun 30;25(2):69-79. Epub 2020 Jun 30.

Department of Pediatrics, University of Chieti, Chieti, Italy.

Short stature is a common reason for referral to pediatric endocrinologists. Multiple factors, including genetic, prenatal, postnatal, and local environmental factors, can impair growth. The majority of children with short stature, which can be defined as a height less than 2 standard deviation score below the mean, are healthy. Read More

JPEN J Parenter Enteral Nutr 2020 Jul 2. Epub 2020 Jul 2.

Department of Clinical Nutrition, Xin Hua Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Background: Clinical research reveals that colon plays an important role in mitigating the effects of short bowel syndrome (SBS). Previously, we showed that the milk fat globule membrane (MFGM) had protective effects on gut barrier integrity in the rat SBS model. Here, we used the same rat model to investigate the effects of enteral MFGM supplementation on gut microbiota and colonic-mucus-barrier function and its related mechanisms. Read More

JPEN J Parenter Enteral Nutr 2020 Jul 2. Epub 2020 Jul 2.

Department of Gastroenterology and Hepatology, Rigshospitalet, Copenhagen, Denmark.

Objective: The aim was to investigate the association between quality of life (QoL), bowel-anatomy and the need for home parenteral support (HPS) volume in non-malignant short bowel syndrome (SBS) patients with intestinal failure (IF).

Design: The SBS-QoL™ scale was used in a cross-sectional study of 95 non-malignant SBS-IF patients. Sum QoL scores (0 best, 170 worst) were calculated. Read More

Cardiol Young 2020 Jun 16:1-4. Epub 2020 Jun 16.

Division of Radiology, Puerta del Mar University Hospital, Cadiz, Spain.

We present our recent experience with a 6-month-old infant with a personal history of short bowel syndrome that presented with fever, cyanosis, and cardiogenic shock secondary to severe pulmonary hypertension and right ventricular failure without pulmonary thromboembolism. He did not present signs of toxin-mediated disease or Kawasaki disease. He was finally diagnosed with SARS-CoV-2 infection. Read More

Am J Physiol Gastrointest Liver Physiol 2020 Jun 29. Epub 2020 Jun 29.

Surgery, Childrens Hospital Los Angeles/The Saban Research Institute, United States.

Short bowel syndrome (SBS) is associated with changes in the intestinal microbiome and marked local and systemic inflammation. There is also a late complication of SBS, intestinal failure associated liver disease (IFALD) in which hepatic steatosis progresses to cirrhosis. Most patients with SBS arrive at massive intestinal resection after a contaminating intraabdominal catastrophe and have a history of exposure to broad spectrum antibiotics. Read More

Biomed Res Int 2020 3;2020:6865917. Epub 2020 Jun 3.

King Abdulaziz Medical City, National Guard Health Affairs, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.

Background And Aims: Celiac disease (CD) is possibly the most common autoimmune disorder, which may lead to dietary problems in the Arab region. This paper is aimed at exploring the epidemiology of the celiac disease in Arab countries, including its prevalence, associated risk factors, and clinical patterns.

Methods: An extensive search of the literature was conducted from electronic databases such as PubMed, Embase, and Google Scholar. Read More

Zhonghua Wei Chang Wai Ke Za Zhi 2020 Jul;23(Z1):69-76

Department of Colorectal Disease Specialty, Intestinal Microecology Diagnosis and Treatment Center, the Tenth People's Hospital, Tongji University, Shanghai 200072, China.

To examine the association between the clinical efficacy of fecal microbiota transplantation (FMT) in recipients and the choice of donor, and to observe the characteristics of intestinal flora and metabolites among different donors. A retrospective case-control study was conducted. Donor whose feces was administrated for more than 30 recipients was enrolled. Read More

Front Bioeng Biotechnol 2020 5;8:476. Epub 2020 Jun 5.

Cell and Molecular Therapy Center (NUCEL), School of Medicine, University of São Paulo, São Paulo, Brazil.

Cell therapy and tissue engineering has recently emerged as a new option for short bowel syndrome (SBS) treatment, generating tissue engineered small intestine (TESI) from organoid units (OU) and biodegradable scaffolds. The recombinant human R-Spondin 1 (rhRSPO1) protein may be a key player in this process due to its mitogenic activity in intestinal stem cells. Aiming at optimizing the TESI formation process and advancing this technology closer to the clinic, we evaluated the effects of rhRSPO1 protein on OU culture and TESI formation. Read More

Transplant Proc 2020 Jun 20. Epub 2020 Jun 20.

Division of Transplant Surgery, Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana. Electronic address:

Background: Intestinal transplantation (ITx) is performed as an isolated ITx or as a part of multivisceral transplantation for intestinal failure secondary to short gut syndrome, inflammatory bowel disease, trauma, and sequelae of chronic parenteral nutrition dependence. Wound complications after ITx are very common, and abdominal wound closure cannot be immediately achieved in half of cases.

Case Presentation: A 25-year-old man sustained an abdominal crush injury causing complete loss of his small intestine, requiring an isolated ITx in March 2016. Read More

Recenti Prog Med 2020 Jun;111(6):13e-16e

UOC di Neonatologia e TIN, Ospedale dei Bambini, ASST Spedali Civili, Brescia.

Introduction: Necrotizing enterocolitis (NEC) is a very aggressive, destructive and sometimes lethal disease, which mainly affects infants born with severe prematurity. These patients need a complex multidisciplinary approach. The clinical course is often long and complicated, and nutritional approach should ensure a balance between the need for nutrients and the risk of complications. Read More

J Clin Gastroenterol 2020 Jun 19. Epub 2020 Jun 19.

Mallinckrodt Pharmaceuticals, Rockville, MD.

Goals: To assess short-term and long-term effects of lubiprostone, a type-2 chloride channel activator, on electrolyte homeostasis.

Background: Conventional laxatives are associated with electrolyte imbalances. Lubiprostone is a type-2 chloride channel activator approved for treating chronic idiopathic constipation (CIC), opioid-induced constipation (OIC), and constipation-predominant irritable bowel syndrome in women. Read More

Nutrition 2020 May 15;79-80:110855. Epub 2020 May 15.

Department of Surgery, Campus Virchow-Klinikum and Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Berlin, Germany; Department of General, Visceral and Vascular Surgery, Evangelisches Krankenhaus Paul Gerhardt Stift, Lutherstadt Wittenberg, Germany. Electronic address:

Objective: Chronic intestinal failure (cIF) is a rare medical condition usually treated by long-term parenteral nutrition (PN). Owing to disease-associated symptoms and treatment-specific complications, patients with cIF commonly present with reduced quality of life (QoL) compared with healthy controls. The aim of this study was to identify factors associated with QoL in patients with cIF. Read More

Aliment Pharmacol Ther 2020 Jul 20;52(2):233-246. Epub 2020 Jun 20.

Department of Gastroenterology, Monash University and Alfred Health, Melbourne, Vic., Australia.

Background: Restriction of dietary FODMAP intake can alleviate symptoms in patients with irritable bowel syndrome. Because many FODMAPs have prebiotic actions, there is concern that their dietary restriction leads to dysbiosis with health consequences, and their intake is being encouraged by addition to foods and via supplements.

Aims: To examine the hazards and benefits of high and low FODMAP intake. Read More

Tech Coloproctol 2020 Jun 19. Epub 2020 Jun 19.

Department of General, Visceral and Transplantation Surgery, Johannes Gutenberg University, Mainz, Germany.

Background: Low anterior resection syndrome (LARS) is associated with a severe negative impact on patients' quality of life (QOL). In a recent prospective randomized controlled trial (RCT) by our group, early ("prophylactic") use of transanal irrigation (TAI) following rectal resection for rectal cancer was shown to improve symptoms associated with LARS significantly compared with a group under supportive therapy (ST) within 1 and 3 months following closure of the protective ileostomy. The aim of the present study was to evaluate the outcome after 12 months when patients had the option to choose between the two therapeutic options and/or modify the regimen of TAI (volume and time). Read More

Prz Gastroenterol 2020 8;15(2):119-125. Epub 2020 Jun 8.

Clinic of Internal Diseases and Gastroenterology, Central Teaching Hospital of the Ministry of Interior and Administration (MSWiA), Warsaw, Poland.

Short-chain fatty acids produced by bacteria living in the large intestine are the main energy substrate for the colonocytes. Butyric acid is used for the treatment and prevention of exacerbations of various gastrointestinal diseases: diarrhoea, intestinal inflammations, functional disorders, dysbiosis, and post-surgery or post-chemotherapy conditions. The current standard doses of butyric acid (150-300 mg) range between 1. Read More

Prz Gastroenterol 2020 17;15(2):103-118. Epub 2019 Jul 17.

Department of Gastroenterology, Pomeranian Medical University, Szczecin, Poland.

Chronic idiopathic constipation (CIC) has emerged as common problem for contemporary gastroenterology and is one of the most frequent complaints in primary care. Chronic idiopathic constipation significantly affects patients' quality of life and has an impact on global health and economy. Functional gastrointestinal disorders and bowel disorders, according to Rome IV criteria, result from inappropriate gut-brain interactions. Read More

World J Gastrointest Pharmacol Ther 2020 Jun;11(2):17-24

Department of Gastroenterology, St Georges Hospital and St Georges, University of London, London SW17 0QT, United Kingdom.

Background: Acromegaly is a chronic disease caused by a pituitary somatotroph adenoma resulting in excess secretion of growth hormone, which leads to excess secretion of Insulin like growth factor 1 from the liver, causing abnormal soft tissue growth. There is increasing awareness that diseases affecting connective tissue are associated with an increase in functional gastrointestinal symptoms. Data was collected from patients with a confirmed diagnosis of acromegaly to evaluate the intensity, variety and impact of abdominal symptoms in comparison with a control group who were healthy participants recruited from the local fracture clinic. Read More

SAGE Open Med 2020 24;8:2050312120923227. Epub 2020 May 24.

Department of Gastroenterological Surgery, Kameda Medical Center, Kamogawa, Japan.

Objective: Acute mesenteric ischemia is often fatal, and many survivors develop short bowel syndrome. To avoid massive bowel resection, revascularization is recommended for acute mesenteric ischemia patients. However, whether acute mesenteric ischemia patients with clinical peritonitis can be revascularized remains uncertain. Read More

Int J Environ Res Public Health 2020 Jun 13;17(12). Epub 2020 Jun 13.

Department of Gastroenterology and Internal Medicine, Medical University of Bialystok, 15-089 Bialystok, Poland.

Background: Irritable bowel syndrome (IBS) is one of the most common functional diseases of the gastrointestinal tract. A typical symptom is changed bowel patterns: diarrhea, constipation, or alternation of the two. Abdominal pains vary in intensity and location, with periods of exacerbation and remission, causing disorganization in everyday life and work. Read More

J Surg Res 2020 Jun 15;255:86-95. Epub 2020 Jun 15.

Developmental Biology and Regenerative Medicine, Saban Research Institute, Children's Hospital Los Angeles and USC Keck School of Medicine, Los Angeles, California; Division of Pediatric Surgery, Department of Surgery, Children's Hospital Los Angeles, Los Angeles, California; Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California. Electronic address:

Background: Short bowel syndrome (SBS) is a condition that results from inadequate intestinal absorptive capacity, usually after the loss of functional intestine. We have previously developed a severe model of SBS in zebrafish that demonstrated increased intestinal adaptation (IA) and epithelial proliferation in SBS zebrafish. However, many children with SBS do not have this extreme intestinal loss. Read More

Arch Iran Med 2020 Jun 1;23(6):422-425. Epub 2020 Jun 1.

Shiraz Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

We have recently established an intestinal rehabilitation unit (IRU) in Abu Ali Sina transplantation center affiliated to Shiraz University of Medical Sciences, Iran. Our intestinal failure rehabilitation and transplant program aims to provide state-of-the-art care for adult patients with different degrees of intestinal insufficiency and failure. In the IRU, we aimed to design an algorithmic approach to patients with small bowel ischemia and short bowel syndrome (SBS) based on our institutional experience in our country and based on other pioneering studies from other regions of the world. Read More

BMC Gastroenterol 2020 Jun 12;20(1):187. Epub 2020 Jun 12.

Department of Gastroenterology and Hepatology, the First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510080, China.

Background: Gut microbiota alterations including small intestinal bacterial overgrowth (SIBO) might play a role in pathogenesis of irritable bowel syndrome (IBS). Rifaximin could effectively and safely improve IBS symptoms. The aim of this study was to investigate the effect of rifaximin on Gastrointestinal (GI) symptoms, quality of life (QOL) and SIBO eradication in Chinese IBS-D patients. Read More

Clin Exp Pharmacol Physiol 2020 Jun 8. Epub 2020 Jun 8.

Department of Medical Pharmacology, Faculty of Medicine, Cairo University, Cairo, Egypt.

Glucagon-like peptides (GLPs); GLP-1 and GLP-2, are released from intestinal enteroendocrine (L cells) in response to ingested nutrients. GLP-1 plays a crucial role in lowering blood glucose and controlling body weight, through stimulating the islet ß cells of pancreas to secret insulin, inhibiting gastric emptying, and reducing food ingestion. Therefore, GLP-1 receptor agonists are now used in the treatment of obese patients with type 2 diabetes mellitus (T2DM). Read More

JPEN J Parenter Enteral Nutr 2020 Jun 8. Epub 2020 Jun 8.

Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

Background: Children with chronic intestinal failure have a high prevalence of anemia, commonly from iron deficiency, leading to frequent blood transfusions. No current guideline exists for iron supplementation in these children. In this analysis, we evaluate the effectiveness and the cost-effectiveness of using parenteral, enteral, and no iron supplementation to reduce blood transfusions. Read More

Sci Rep 2020 Jun 4;10(1):9146. Epub 2020 Jun 4.

Université Clermont Auvergne, 3iHP, CNRS, Laboratoire Microorganismes: Génome et Environnement, F-63000, Clermont-Ferrand, France.

Background: Infectious gastroenteritis is a risk factor for the development of post-infectious Irritable Bowel Syndrome (PI-IBS). Recent clinical studies reported a higher prevalence of the intestinal parasite Blastocystis in IBS patients. Using a rat model, we investigated the possible association between Blastocystis infection, colonic hypersensitivity (CHS), behavioral disturbances and gut microbiota changes. Read More

Gastroenterol Rep (Oxf) 2019 Dec 13;7(6):459-460. Epub 2019 Jul 13.

Department of Surgery, Oncology and Gastroenterology, University of Padua, Padua, Italy.

Neoreviews 2020 Jun;21(6):e370-e382

Pediatric Surgery, Monroe Carell Jr Children's Hospital at Vanderbilt, Nashville, TN.

Short bowel syndrome (SBS) is a malabsorptive state that may occur either after surgical bowel resection or as the result of congenital bowel anomalies. SBS can incur significant morbidity and mortality including intestinal failure, cholestasis, sepsis, and death. For patients with SBS, management involves a multidisciplinary approach that begins with neonatology, pediatric surgery, nutritionists, pharmacists, and nurses in the NICU and also includes the transition to an intestinal rehabilitation program. Read More

J Neurosurg Pediatr 2020 May 29:1-6. Epub 2020 May 29.

Objective: The goal of this study was to establish an incidence and assess the effect of tethered cord release for tethered cord syndrome in patients with myelomeningocele.

Methods: The study population was based on the Western Denmark Myelomeningocele Database, which contains all patients born with myelomeningocele in western Denmark since 1970. The study population was cross-referenced in 2015 with a database for surgical procedures containing all surgical procedures performed in the central Denmark region since 1996. Read More

Colorectal Dis 2020 May 28. Epub 2020 May 28.

Colorectal Sugery Unit, Donostia University Hospital, Donostia, Spain.

J Pediatr 2020 Jun;221:145-150.e2

Department of Radiology and Imaging Sciences, Division of Interventional Radiology and Image Guided Medicine, Emory University, Atlanta, GA; Children's Healthcare of Atlanta, Atlanta, GA.

Objective: To evaluate the hospital charges associated with central venous stenosis in pediatric patients requiring long-term central venous catheters, via associated charges and hospital length of stay (LOS).

Study Design: This institutional review board-approved retrospective review identified pediatric patients with central venous catheters and either short bowel syndrome (SBS) or end-stage renal disease (ESRD) diagnosed between 2008 and 2015 using the Pediatric Health Information System. These 2 cohorts were selected because long-term central venous access is commonly required for survival. Read More

Clin Perinatol 2020 Jun 4;47(2):323-340. Epub 2020 Mar 4.

Division of Gastroenterology, Hepatology & Nutrition, The Ohio State University College of Medicine, Center for Intestinal Rehabilitation and Nutrition Support, Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH 43205, USA.

Pediatric intestinal failure occurs when gut function is insufficient to meet the nutrient and hydration needs of the growing child. The commonest cause is short bowel syndrome with maldigestion and malabsorption following massive bowel loss. The remnant bowel adapts during the process of intestinal rehabilitation. Read More

JPEN J Parenter Enteral Nutr 2020 May 21. Epub 2020 May 21.

Department of Surgery, Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada.

Background: In treating short-bowel syndrome (SBS), autonomy from parenteral nutrition (PN) relies upon intestinal adaptation, which can be augmented by glucagon-like peptide-2 (GLP-2) analogues. In neonatal piglets with SBS, we compared intestinal adaptation following treatment with 2 GLP-2 analogues: teduglutide (TED) and apraglutide (APRA) METHODS: Following 75% distal small-intestinal resection, piglets were allocated to 4 treatment groups: saline (CON: n = 8), twice weekly APRA (5 mg/kg/dose; n = 8), and TED once daily (TED, 0.05 mg/kg/dose; n = 8) or twice daily (TEDBID, 0. Read More

Am J Gastroenterol 2020 Jun;115(6):906-915

Department of Nutritional Sciences, King's College London, London, United Kingdom.

Introduction: The low FODMAP diet (LFD) reduces symptoms and bifidobacteria in irritable bowel syndrome (IBS). β-galactooligosaccharides (B-GOS) may reduce the symptoms and increase bifidobacteria in IBS. We investigated whether B-GOS supplementation alongside the LFD improves IBS symptoms while preventing the decline in bifidobacteria. Read More

Ann Med Surg (Lond) 2020 Jun 4;54:106-108. Epub 2020 May 4.

Department of Digestive Surgery, Fattouma Bourguiba University Hospital, Monastir, Tunisia.

Hamartomatous polyposis is a rare cause of intussusception in adults. But this complication is the most frequent for patient with Peutz Jeghers syndrome. Small bowel screening is recommended for those patients in order to prevent emergency repetitive surgeries. Read More

JPEN J Parenter Enteral Nutr 2020 May 15. Epub 2020 May 15.

Department of Gastroenterology, Hepatology and Nutrition, Seattle Children's Hospital, Seattle, Washington, USA.

Background: SMOFlipid is a mixed-lipid emulsion approved for adults in the United States as an alternative to soybean oil-based lipid (SO). There are limited data on the use of SMOFlipid in pediatrics and its effect on the fatty acid (FA) profile. Our objective was to characterize changes in FA profile, liver function, and growth in pediatric patients with intestinal failure (IF), following transition from SO or a fish-oil (FO) and SO combination to SMOFlipid. Read More

Nutr Hosp 2020 May 14. Epub 2020 May 14.

Hospital Universitario de Basurto.

Intestinal failure (IF) is defined as a reduction in intestinal function below the minimum necessary for the absorption of nutrients, requiring intravenous supplementation to maintain health and/or growth. The most common cause is short bowel syndrome (SBS). Approximately 50% of patients with SBS have IF and require parenteral support. Read More

J Pediatr Gastroenterol Nutr 2020 May 11. Epub 2020 May 11.

Department of Paediatric Gastroenterology, University Hospital Southampton, Tremona Road, Southampton, UK.

Objectives: Caring for a child on home parenteral nutrition (HPN) is stressful, and its emotional impact not fully appreciated. This study explored the emotional wellbeing and coping styles of parents and children on HPN.

Methods: Questionnaire data was collected for parents of children (0-18 years) on HPN. Read More

J Pediatr Gastroenterol Nutr 2020 May 11. Epub 2020 May 11.

Department of Pediatrics, University of Alberta, Edmonton Clinic Health Academy, 11405 - 87th Avenue NW, Edmonton, Alberta, T6G 1C9, Canada.

The North American Society of Pediatric Gastroenterology, Hepatology, and Nutrition (NASPGHAN) developed NASPGHAN Nutrition University (N2U) in 2012 to improve nutrition education for pediatric gastroenterology providers. A total of 543 providers (physicians, registered dietitians, and advanced practice nurses) have applied to N2U and 285 have attended this 2-day course. We used survey methodology to compare attendees to applicants who did not attend. Read More

J Surg Res 2020 May 8;254:7-15. Epub 2020 May 8.

Department of Visceral-, Transplantation-, Thoracic and Vascular Surgery, University Hospital Leipzig, Leipzig, Germany.

Background: Acute mesenteric ischemia is a life-threatening acute condition, which requires an interdisciplinary approach, including vascular recanalization and surgical treatment. Visual evaluation of intestinal perfusion might be misleading, and therefore, additional tools are necessary to reliably be able to resect the ischemic intestine. Hyperspectral imaging (HSI) has been shown to be feasible and safe for real-time assessment of tissue perfusion in visceral surgery but has never been used in cases of acute mesenteric ischemia. Read More

JPEN J Parenter Enteral Nutr 2020 May 11. Epub 2020 May 11.

Department of Internal Medicine, Section of Gastroenterology, Hepatology and Nutrition, University of Chicago Medicine, Chicago, Illinois, USA.

Background: The aim of this study was to quantify the long-term clinical outcomes for individuals receiving teduglutide for short-bowel syndrome (SBS).

Methods: A single-center, retrospective study was performed for individuals commencing use of teduglutide between March 2013 and May 2019.

Results: Eighteen patients were included in the final analysis, among which the median duration of teduglutide administration was 3. Read More

Gan To Kagaku Ryoho 2020 Apr;47(4):643-645

Dept. of Surgery, Japan Community Health Care Organization Shimonoseki Medical Center.

Abdominal computed tomography(CT)revealed ileus due to sigmoid colon cancer in a 68-year-old man with abdominal pain, and endoscopic decompression using a transanal ileus tube was attempted. The blood test on the following day showed a marked increase in CRP 46.13mg/dL. Read More

JPEN J Parenter Enteral Nutr 2020 May 9. Epub 2020 May 9.

University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.

Background: Central line-associated bloodstream infection (CLABSI) is a potentially life-threatening complication in home parenteral nutrition (HPN) patients. We investigated potential predictors of CLABSI in a cohort of adult HPN patients METHODS: Patients managed by the HPN service at the Hospital of University of Pennsylvania on January 1, 2018, were included and followed through June 30, 2019, using existing medical records to collect demographic and clinical data. CLABSIs were adjudicated prospectively by infectious disease experts. Read More

JPEN J Parenter Enteral Nutr 2020 May 8. Epub 2020 May 8.

Toronto General Hospital, University of Toronto, Toronto, Canada.

Introduction: Severe gastrointestinal dysmotility disorder (GID) constitute approximately 20% of patients requiring home parenteral nutrition (HPN), whereas short-bowel syndrome (SBS) remains the most frequent indication for HPN. This study's aim was to characterize GID patients and compare clinical parameters and survival to SBS patients. Similarly, clinical comparisons between sclerodermaand nonscleroderma patients were made. Read More

Nutr Hosp 2020 May 7. Epub 2020 May 7.

UGC Endocrinología y Nutrición. Hospital Universitario Virgen del Rocío.

Introduction: home parenteral nutrition (HPN) is a fundamental treatment for patients with intestinal failure who do not require hospitalization. We aimed to conduct an epidemiological and clinical practice analysis of HPN through a systematic review.

Methods: the systematic review was conducted according to the PRISMA guidelines. Read More

JPEN J Parenter Enteral Nutr 2020 May 4. Epub 2020 May 4.

Department of Pediatrics, Section of Neonatology, Baylor College of Medicine, Texas Children's Hospital, Houston, Texas, USA.

Background: It is challenging to provide optimum nutrition in low-birth-weight (LBW) infants with short-bowel syndrome (SBS) and ostomy. This study aims to evaluate the clinical course of LBW infants with SBS and ostomy in response to enteral feeds, recognize characteristics associated with achievement of enteral autonomy prior to reanastomosis, and evaluate associated short-term outcomes.

Methods: A retrospective analysis of 52 LBW neonates with intestinal failure (IF) caused by SBS and ostomy treated in a neonatal intensive care unit from 2012 to 2018 was performed. Read More

Clin Nutr ESPEN 2020 Jun 16;37:50-57. Epub 2020 Apr 16.

Dept of Gastroenterology and Hepatology, Intestinal Failure Unit, Radboud University Nijmegen Medical Centre, the Netherlands.

Background & Aims: Home total parenteral nutrition (HPN) is indicated in long-term intestinal failure (IF) to maintain or improve the nutritional status, guarantee patient survival and improve quality of life (QoL). The patients "caregiver" is often an essential partner to help perform daily activities. The aim of this study was to compare QoL, experienced distress and (if present) caregiver burden for relatives in two distinct categories of IF patients, i. Read More

Hepatol Int 2020 May 30;14(3):305-316. Epub 2020 Apr 30.

Section of Pediatric Gastroenterology, Hepatology and Nutrition and the Digestive Health Institute, Pediatric Liver Center, Colorado Clinical and Translational Sciences Institute, University of Colorado School of Medicine and Children's Hospital Colorado, 13123 E. 16th Ave., Box B290, Aurora, CO, 80045, USA.

Premature infants and children with intestinal failure (IF) or short bowel syndrome are susceptible to intestinal failure-associated liver disease (IFALD, previously referred to as parenteral nutrition-associated liver disease, or PNALD). IFALD in children is characterized by progressive cholestasis and biliary fibrosis, and steatohepatitis in adults, and is seen in individuals dependent upon prolonged administration of PN. Many factors have been proposed as contributing to the pathogenesis of IFALD. Read More

Z Gastroenterol 2020 Apr 30;58(4):364-372. Epub 2020 Apr 30.

Klinik und Poliklinik für Allgemein-, Viszeral-, Thorax- und Gefäßchirurgie, Universitätsklinikum Bonn, Germany.

Introduction:  Short-bowel-syndrome (SBS) is an often chronic disease with high morbidity. The aim of this study was to evaluate the complexity of SBS treatment and the economic burden on a treating hospital.

Methods:  Anonymized data of eleven consecutive SBS patients from the University Hospital of Bonn were included. Read More