4,070 results match your criteria Short-Bowel Syndrome


Impact of an In-House Pediatric Surgery Unit and Human Milk Centered Enteral Nutrition on Necrotizing Enterocolitis.

Biomed Res Int 2018 13;2018:5042707. Epub 2018 Nov 13.

EKO Children's Hospital, Oberhausen, Witten/Herdecke University, Germany.

The importance for mortality and morbidity of an in-house pediatric surgery unit for premature infants with necrotizing enterocolitis (NEC) remains undefined. Data on 389 consecutive very low birth weight infants with a birth weight <1250 g admitted between 2009 and 2014 was retrospectively analyzed in two almost identical neonatal intensive care units. Epidemiological data (n=172 and n=217, respectively) were comparable. Read More

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November 2018

Developing a Novel Ambulatory Total Parenteral Nutrition-Dependent Short Bowel Syndrome Animal Model.

J Surg Res 2019 Feb 27;234:13-19. Epub 2018 Sep 27.

Department of Pediatrics, Saint Louis University School of Medicine, Saint Louis, Missouri. Electronic address:

Background: Short bowel syndrome (SBS) results from extensive bowel resection. Patients with SBS require total parenteral nutrition (TPN) for survival. Understanding mechanisms contributing to TPN-associated liver injury and gut atrophy are critical in developing SBS therapies. Read More

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February 2019

[Home and Ambulatory Artificial Nutrition (NADYA) Report. Home Parenteral Nutrition in Spain, 2017].

Nutr Hosp 2018 Dec 3;35(6):1491-1496. Epub 2018 Dec 3.

1. Hospital General Universitario de Alicante, Alicante, España. 2. Fundación para el Fomento de la Investigación Sanitaria y Biomédica (ISABIAL-FISABIO), Alicante, España..

Aim: to communicate HPN data obtained from the HPN registry of the NADYA-SENPE group (www.nadya-senpe.com) for the year 2017. Read More

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December 2018
1 Read

Clinical Features and Outcomes of Patients With Acute Mesenteric Ischemia and Concomitant Colon Ischemia: A Retrospective Cohort Study.

J Surg Res 2019 Jan 31;233:231-239. Epub 2018 Aug 31.

Department of Vascular Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.

Background: Early identification of patients with acute mesenteric ischemia (AMI) involving the large bowel may play a decisive role in improving the prognosis of AMI. This study aims to compare the outcomes between patients with isolated AMI and AMI patients with colon involvement (CI) and to identify the predictors of worse outcomes. The different surgical modalities for AMI patients with CI were also evaluated. Read More

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January 2019
1 Read

Retracing our STEPs: Four decades of progress in intestinal lengthening procedures for short bowel syndrome.

Am J Surg 2018 Nov 27. Epub 2018 Nov 27.

Section of Pediatric Surgery, Department of Surgery, Yale School of Medicine, New Haven, CT, 06520, USA. Electronic address:

The surgical management of intestinal failure secondary to short bowel syndrome has undergone tremendous evolution in the last several decades. From the landmark description of an intestinal lengthening procedure by Bianchi in 1980 to the multidisciplinary modern care paradigm known as intestinal rehabilitation, innovative new treatments in this field have vastly improved patient outcomes. Initial attempts to treat short bowel syndrome surgically saw the birth of reversed intestinal segments, artificial valves and colonic transposition, all aimed at decreasing transit time and thus increasing absorption. Read More

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November 2018

Pediatric Home Parenteral Nutrition: Indications and Short-Term Outcomes in a Large National Sample of Commercially Insured Children and Adolescents.

Nutr Clin Pract 2018 Dec 3. Epub 2018 Dec 3.

College of Pharmacy-Glendale, Midwestern University, Glendale, Arizona, USA.

Background: To support families managing the complex requirements of home parenteral nutrition (HPN) in pediatric patients, health professionals need information about HPN indications and complications. Nationally representative information is limited.

Methods: A retrospective cohort analysis of the Truven Health Market Scan Commercial Claims and Encounters Database was performed and identified 683 patients aged ≤18 years receiving HPN during dates of service from January 2013 through September 2015. Read More

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December 2018
3 Reads

The Association of Nil Per Os (NPO) Days with Necrotizing Enterocolitis.

Gastroenterol Res Pract 2018 30;2018:2795468. Epub 2018 Oct 30.

Ministry of Education Key Laboratory of Child Development and Disorders, Children's Hospital, Chongqing Medical University, Chongqing, China.

Background: Enteral feeds are an essential part of care for infants and may be a potential risk factor in NEC development. The present study objective was to evaluate the relationship between nil per os (NPO) and clinical outcomes in infants with NEC.

Methods: This was a retrospective review of 196 premature, low-birth-weight infants with NEC from January 1, 2011, to October 31, 2016, at four academic tertiary care hospitals. Read More

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October 2018
1 Read

Non-transplant surgical management of short bowel syndrome in children: an overview.

Curr Pediatr Rev 2018 Nov 29. Epub 2018 Nov 29.

University of Florence, Meyer Children's Hospital, Florence. Italy.

Management of severe Short Bowel Syndrome (SBS) is still one of the largest challenges of the medicine. Vast majority of the short bowel patients are children, the conditions that lead to this possible outcome most often are necrotizing enterocolitis (NEC), small intestinal volvulus as a result of intestinal malrotation, gastroschisis and the "apple peel" syndrome. Therefore paediatricians and paediatric surgeons face this challenge most often. Read More

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November 2018
2 Reads

Long Term Outcome Of Infants With Nec.

Curr Pediatr Rev 2018 Nov 30. Epub 2018 Nov 30.

Pediatric surgery Unit - INFERMI Hospital- Rimini. Italy.

Necrotizing enterocolitis (NEC) is a significant complication for premature newborns. Infants who survive NEC are at increased risk of having poor long-term physiological and neurodevelopmental growth. The objective of this paper is to give a comprehensive description of the long-term consequences of NEC. Read More

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November 2018
3 Reads

Small Bowel Transplantation.

Surg Clin North Am 2019 Feb;99(1):103-116

Division of Abdominal Transplant Surgery, Duke University Medical Center, DUMC Box 3522, Durham, NC 27710, USA. Electronic address:

Intestinal and multivisceral transplants are complex technical procedures that present unique challenges in the field of solid organ transplantation. This review aims to highlight the indications, techniques, outcomes, and complications specific to intestinal transplantation. Read More

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February 2019
3 Reads

Practical measurement of body composition using bioelectrical impedance, air displacement plethysmography and ultrasound in stable outpatients with short bowel syndrome receiving home parenteral nutrition: comparison of agreement between the methods.

J Hum Nutr Diet 2018 Nov 22. Epub 2018 Nov 22.

Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.

Background: People diagnosed with intestinal failure (IF) as a result of short bowel syndrome are dependent on home parenteral nutrition (HPN). Measuring nutritional status is essential for monitoring treatment. The present study aimed to determine the agreement and feasibility of three methods bioelectrical impedance analysis (BIA), ultrasound and air displacement plethysmography (ADP) for measuring body composition in people receiving HPN. Read More

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November 2018
2 Reads

An iso-osmolar oral supplement increases natriuresis and does not increase stomal output in patients with an ileostomy: A randomised, double-blinded, active comparator, crossover intervention study.

Clin Nutr 2018 Oct 24. Epub 2018 Oct 24.

Department of Hepatology and Gastroenterology, Aarhus University Hospital, DK-8200, Denmark. Electronic address:

Background: Patients with an ileostomy often experience fluid and electrolyte depletion because of gastrointestinal loss. This study aimed to compare how an iso-osmolar and a hyperosmolar oral supplement affect ileostomy output, urine production, and natriuresis as proxy measurements of water-electrolyte balance.

Methods: In a randomised, double-blinded, active comparator, crossover intervention study, we included eight adult ileostomy patients who were independent of parenteral support. Read More

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October 2018
10 Reads

A Treatment for Refractory High Ileostomy Output.

J Pain Palliat Care Pharmacother 2018 Nov 5:1-3. Epub 2018 Nov 5.

We present a case where the glucagon-like peptide 2 (GLP-2) analog teduglutide was used successfully to decrease high ostomy output due to short bowel syndrome in a patient not entirely dependent on parenteral nutrition. Short bowel syndrome is known to decrease quality of life and is associated with high health care costs. Although use has been limited by cost, teduglutide appears to be a treatment option for palliative care practice if patients suffer from short bowel syndrome. Read More

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November 2018
9 Reads

Measurement of Utilities Associated with Parenteral Support Requirement in Patients with Short Bowel Syndrome and Intestinal Failure.

Clin Ther 2018 Nov 2;40(11):1878-1893.e1. Epub 2018 Nov 2.

Salford Royal NHS Foundation Trust, Salford, United Kingdom.

Purpose: Short bowel syndrome (SBS) is the main cause of intestinal failure. Intravenous supplementation (parenteral support [PS]) helps patients regain health but can affect patients' health-related quality of life (HRQoL). The value of health states associated with the number of days on PS per week is unknown in the United Kingdom. Read More

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November 2018

Medical and nutritional treatment in adult patients with acute intestinal failure.

Rev Clin Esp 2018 Oct 31. Epub 2018 Oct 31.

Servicio de Nutriología Clínica, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México, México. Electronic address:

Acute intestinal failure is a reversible clinical condition characterised by reduced intestinal function, which requires the intravenous supplementation of nutrients, water and/or electrolytes for weeks or months to maintain an optimal state of health. Acute intestinal failure occurs mainly in postsurgical patients who have undergone abdominal operations or are critically ill and have organ dysfunction. These patients' medical and nutritional management can be a complex and prolonged process due to the associated complications such as electrolyte imbalances, malnutrition, sepsis and metabolic disorders. Read More

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October 2018
2 Reads

Home parenteral support in patients with incurable cancer. Patient characteristics of importance for catheter related complications and overall survival.

Clin Nutr ESPEN 2018 Dec 12;28:88-95. Epub 2018 Oct 12.

Department of Medical Gastroenterology, Odense University Hospital, Denmark; Institute of Clinical Research, University of Southern Denmark, Denmark. Electronic address:

Purpose: It is uncertain if home parenteral support (HPS) is of advantage in patients with incurable cancer and intestinal failure, functional obstruction or severe malabsorption. From a single centre cohort we present characteristics of patients with incurable cancer treated with HPS.

Methods: Over a ten year period (2005-2015) data were retrospectively collected on patients with incurable cancer discharged on HPS from a Danish tertiary referral centre. Read More

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December 2018
6 Reads

Surgeon's perspective on short bowel syndrome: Where are we?

World J Transplant 2018 Oct;8(6):198-202

Liver and Multiorgan Transplant Unit, St. Orsola-Malpighi University Hospital, Bologna 40138, Italy.

Short bowel syndrome (SBS) is due to a massive loss of small bowel: the reduction of gut function is below the minimum necessary to maintain health (in adults) and growth (in children) so intravenous supplementation is required. Parenteral nutrition represents the milestone of treatment and surgical attempts should be limited only when the residual bowel is sufficient to increase absorption, reducing diarrhea and slowing the transit time of nutrients, water and electrolytes. The surgical techniques lengthen the bowel (tapering it) or reverse a segment of it: developed in children, nowadays are popular also among adults. Read More

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October 2018
9 Reads

Are there differences in the growth adaptation processes of growing and mature organism models of short bowel syndrome?

Clinics (Sao Paulo) 2018 Oct 18;73:e499. Epub 2018 Oct 18.

Divisao de Cirurgia Pediatrica, Unidade Pediatrica de Transplante de Figado e Laboratorio de Pesquisa em Cirurgia Pediatrica (LIM 30), Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, SP, BR.

Objectives: The purpose of this study was to present an experimental model of short bowel syndrome (SBS) in weaning rats and to compare the adaptative mechanisms of the remaining bowel in weaning rats and adult animals by means of morphometric, histologic and molecular methods.

Methods: Twenty-four weaning rats were divided into 3 groups of 8 animals, one control group and two short bowel groups (euthanasia after 4 and 21 days), and were compared with similar adult groups. Morphometric evaluations of the animals and histopathological and molecular studies of the remaining bowel were performed. Read More

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October 2018
3 Reads

GLP-2 analog teduglutide significantly reduces need for parenteral nutrition and stool frequency in a real-life setting.

Therap Adv Gastroenterol 2018 30;11:1756284818793343. Epub 2018 Aug 30.

Department of Gastroenterology, Hepatology and Infectious Diseases, University Hospital Tübingen, Tübingen, Otfried-Müller-Str. 10, 72076 Germany.

Background: To evaluate the benefits of teduglutide in a real-life setting, we analyzed the data of 14 patients with short bowel syndrome treated with teduglutide. Additionally, we studied glucagon-like peptide 2 (GLP-2) receptor expression in samples of small intestinal and colonic tissue to provide explanations for clinical observations.

Methods: Stool frequency and consistency, sensation of thirst, parental calorie or fluid uptake and the number of days on parenteral support per week were collected for up to 2 years. Read More

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Intestinal lengthening via multiple in-continuity springs.

J Pediatr Surg 2018 Oct 5. Epub 2018 Oct 5.

Division of Pediatric Surgery, Department of Surgery, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA; Division of Pediatric Surgery, Department of Surgery, Stanford University School of Medicine, Stanford, California, USA. Electronic address:

Background: Short bowel syndrome is a debilitating condition with few effective treatments. Spring-mediated distraction enterogenesis can be used to lengthen intestine. The purpose of this study is to determine whether multiple springs in series can safely increase the total amount of lengthening. Read More

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October 2018
1 Read

Health-related quality of life and neurodevelopmental outcomes among children with intestinal failure.

Semin Pediatr Surg 2018 Aug 29;27(4):273-279. Epub 2018 Jul 29.

Pediatric Liver and Gut Research Group, Children's Hospital, Helsinki University Hospital, P.O. Box 281, 00029 HUS Helsinki, Finland; Section of Pediatric Surgery, Children's Hospital, Helsinki University Hospital, Finland. Electronic address:

Treatment results of pediatric intestinal failure have improved markedly during the last decades. With improved survival the attention is turning to other essential outcomes including quality of life and neurodevelopment. So far, relatively few studies with limited number of patients and variable methodology have addressed these issues. Read More

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August 2018
1 Read

Improvements in intestine transplantation.

Semin Pediatr Surg 2018 Aug 29;27(4):267-272. Epub 2018 Jul 29.

Thomas E Starzl Transplantation Institute, Hillman Center for Pediatric Transplantation of the Children's Hospital of Pittsburgh of University of Pittsburgh Medical Center (UPMC), Pittsburgh, PA, USA. Electronic address:

Transplantation of the intestine in children has presented significant challenges even as it has become a standard to treat nutritional failure due to short gut syndrome. These challenges have been addressed in part by significant improvements in short and long-term care. Noteworthy enhancements include reduced need for intestine transplantation, drug-sparing immunosuppressive regimens, immune monitoring, and improved surveillance and management of PTLD and non-adherence. Read More

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August 2018
6 Reads

Autologous intestinal reconstruction surgery.

Semin Pediatr Surg 2018 Aug 8;27(4):261-266. Epub 2018 Sep 8.

Department of Surgery, Boston Children's Hospital, 300 Longwood Avenue, Fegan 3 Boston, MA 02115, United States. Electronic address:

The management of short bowel syndrome has mainly been focused on intestinal rehabilitation as part of multidisciplinary team approach in specialized centers. While some patients go through a process of bowel adaptation that allows them to reach enteral autonomy, others reach a plateau before this and require prolonged parenteral nutrition and/or intestinal transplantation. Various autologous intestinal reconstruction procedures centered on bowel tapering have been described to increase functional intestinal area and help gain enteral autonomy. Read More

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August 2018
5 Reads

Insights into medical management of pediatric intestinal failure.

Semin Pediatr Surg 2018 Aug 29;27(4):256-260. Epub 2018 Jul 29.

Division of Gastroenterology, Hepatology and Nutrition Cincinnati Children's Hospital Medical Center, MLC 2010, 3333 Burnet Avenue, Cincinnati, OH 45229, United States; Department of Pediatrics, College of Medicine, University of Cincinnati, United States. Electronic address:

Medical management of children with Intestinal failure continues to evolve. The development of specialized teams focused on the management of these children has made the most significant impact in improving outcomes. Medical management strategies are centered on the provision of adequate fluid electrolytes and calories to allow for appropriate growth and neurological development. Read More

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August 2018
4 Reads

Advances in glucagon like peptide-2 therapy. physiology, current indications and future directions.

Authors:
D L Sigalet

Semin Pediatr Surg 2018 Aug 29;27(4):237-241. Epub 2018 Jul 29.

Department of Pediatric Surgery, Sidra Medical and Research Center, Doha, Qatar; Professor of Surgery, Weill Cornell Medical College, Doha, Qatar. Electronic address:

The treatment paradigm for pediatric patients with short bowel syndrome (SBS) and intestinal failure (IF) has changed significantly over recent years; the development of dedicated IF teams, refinements in PN and surgical treatments have greatly improved survival. The majority of SBS patients undergo intestinal adaptation such that nutrient absorption from enteral feeds increases and the child can come off of PN. This "adaptation" or upregulation in nutrient absorptive capacity is still poorly understood; the enteric hormone Glucagon like peptide 2 (GLP-2) appears to be a key regulator in this process. Read More

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August 2018
6 Reads

An anatomic approach to understanding mechanisms of intestinal adaptation.

Semin Pediatr Surg 2018 08 29;27(4):229-236. Epub 2018 Jul 29.

Division of Pediatric Surgery, St. Louis Children's Hospital, One Children's Place, Suite 6110, St. Louis, 63110 MO, USA; Department of Surgery, Washington University School of Medicine, St. Louis, USA. Electronic address:

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August 2018
4 Reads

Intestinal microbiota in short bowel syndrome.

Authors:
Hannah G Piper

Semin Pediatr Surg 2018 Aug 27;27(4):223-228. Epub 2018 Jul 27.

Division of Pediatric Surgery, University of British Columbia/BC Children's Hospital, 4480 Oak Street, Vancouver, BC V6H 3V4, Canada. Electronic address:

Children with short bowel syndrome have significant changes to their intestinal microbiota after intestinal loss. The purpose of this article is to understand the potential implications of these changes on gut function, hepatic cholestasis and overall nutrition. Possible therapies to restore the commensal bacterial community in these patients will also be reviewed. Read More

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August 2018
10 Reads

Organization and outcomes of multidisciplinary intestinal failure teams.

Semin Pediatr Surg 2018 Aug 27;27(4):218-222. Epub 2018 Jul 27.

Division of Gastroenterology and Hepatology, Seattle Children's Hospital and University of Washington School of Medicine, Seattle, WA, USA.

Multidisciplinary intestinal failure programs have played a leading role in the improved outcomes observed in children with intestinal failure over the past two decades. These teams evolved from the world of transplantation and now provide comprehensive care of intestinal failure patients and their families. In addition, they provide the foundation for outcomes research and clinical trials in pediatric intestinal failure. Read More

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August 2018
4 Reads

Etiology and prognosis of pediatric short bowel syndrome.

Semin Pediatr Surg 2018 Aug 29;27(4):209-217. Epub 2018 Jul 29.

Division of General and Thoracic Surgery, The Hospital for Sick Children, University of Toronto, Toronto, Canada; Group for Improvement of Intestinal Function and Treatment (GIFT), The Hospital for Sick Children, University of Toronto, Toronto, Canada; Transplant and Regenerative Medicine Centre, The Hospital for Sick Children, University of Toronto, Toronto, Canada. Electronic address:

Pediatric intestinal failure is a complex and devastating condition defined as the inability of the intestine to absorb an adequate amount of fluid and nutrients to sustain life. The primary goal of intestinal failure treatment is to achieve enteral autonomy with a customized treatment plan. Although recent improvements in intestinal failure patient care have led to significant improvements in the morbidity and mortality rate, children with intestinal failure are at risk for multiple complications such as intestinal failure associated liver disease, recurrent septic episodes, central line complications, metabolic bone disease, impaired kidney function, and failure to thrive. Read More

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August 2018
7 Reads

Short bowel syndrome (by Tom Jaksic and Biren Modi).

Authors:
Tom Jaksic

Semin Pediatr Surg 2018 08 29;27(4):207-208. Epub 2018 Jul 29.

Center for Advanced Intestinal Rehabilitation (CAIR), Boston Children's Hospital and Department of Pediatric Surgery Boston Children's Hospital, Harvard Medical School. Electronic address:

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Expanding intestinal segment using osmotic hydrogel: An in vivo study.

J Biomed Mater Res B Appl Biomater 2018 Oct 12. Epub 2018 Oct 12.

Paediatric Autologous Bowel Reconstruction and Rehabilitation Unit, Department of Paediatric Surgery, Royal Manchester Children's Hospital, Manchester, UK.

Intestinal circumferential expansion is essential for bowel lengthening in patients with Short Bowel Syndrome. We hypothesized use of an endoluminal osmotic hydrogel expander (EOHE) as a novel approach for intestinal expansion. An EOHE was introduced into an isolated intestinal segment of New Zealand rabbits, with a similar segment created as a control. Read More

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October 2018
2 Reads

The effect of intravenous lipid emulsions and mucosal adaptation following massive bowel resection.

J Pediatr Surg 2018 Dec 1;53(12):2444-2448. Epub 2018 Oct 1.

Department of Pediatric Surgery, Research Field in Medicine and Health Sciences, Medical and Dental Sciences Area, Research and Education Assembly, Kagoshima University, Kagoshima City, Japan. Electronic address:

Aims And Objectives: Fish oil (FO) lipid emulsion and a new lipid emulsion (SMOF) are important treatments for intestinal failure-associated liver disease. We evaluated the efficacy of FO and SMOF lipid emulsion on intestinal mucosal adaptation using a total parenteral nutrition (TPN)-supported rat model of short bowel syndrome.

Material & Methods: Sprague-Dawley rats underwent jugular vein catheterization and 90% small bowel resection and were divided into three groups: TPN with soy bean oil lipid emulsion (SO group), FO lipid emulsion (FO group), or SMOF (SMOF group). Read More

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December 2018
3 Reads

Pharmacokinetics of the Meropenem Component of Meropenem-Vaborbactam in the Treatment of KPC-Producing Klebsiella pneumoniae Bloodstream Infection in a Pediatric Patient.

Pharmacotherapy 2018 Dec 9;38(12):e87-e91. Epub 2018 Nov 9.

St. Christopher's Hospital for Children, Philadelphia, Pennsylvania.

Meropenem-vaborbactam is a new β-lactam/β-lactamase inhibitor combination designed to target Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae. Meropenem-vaborbactam was United States Food and Drug Administration-approved for complicated urinary tract infections in patients 18 years of age or older. An understanding of the pharmacokinetics of meropenem when given in combination with vaborbactam is important to understanding the dosing of meropenem-vaborbactam. Read More

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December 2018
6 Reads

Neonatal vitamin K deficiency in the son of a mother with short bowel syndrome.

Pediatr Int 2018 Oct 8;60(10):991-992. Epub 2018 Oct 8.

Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan.

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October 2018
7 Reads

Short bowel syndrome caused by laparoscopic loop enterostomy of the jejunum in an adult with undiagnosed intestinal malrotation: A case report.

Medicine (Baltimore) 2018 Oct;97(40):e12712

Department of Diagnostic Radiology, Chang Gung Memorial Hospital Chiayi Branch, Chiayi.

Rationale: Failure to recognize intestinal malrotation in adults can cause complications during surgeries, especially those with a limited operative field. We report a case of short bowel syndrome caused by mistaken creation of a loop enterostomy in the jejunum due to undiagnosed intestinal malrotation.

Patient Concerns: A 72-year-old man underwent a laparoscopic right hemicolectomy and ileocolostomy because of complicated diverticulitis. Read More

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October 2018
3 Reads

Iatrogenic (Traumatic) Occipital Artery Pseudoaneurysm - Rare Complication of Ventriculoperitoneal Shunt in an Infant: Case Report and Review of the Literature.

Asian J Neurosurg 2018 Jul-Sep;13(3):914-917

Department of Radiology, Sheikh Khalifa Medical City, Abu Dhabi, UAE.

Although ventriculoperitoneal shunt (VPS) is the most common procedure performed by pediatric neurosurgeons, it is still associated with frustrating complications, most common of which are obstruction and infection. Traumatic occipital artery pseudoaneurysm is a very rare complication of VPS procedure. To the best of our knowledge, there is no similar case reported in the English language literature. Read More

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October 2018
2 Reads

Tunneled central venous catheters in pediatric intestinal failure: a single-center experience.

J Surg Res 2018 Nov 29;231:346-351. Epub 2018 Jun 29.

Department of Pediatric Surgery, Center for Surgical Trials and Evidence-based Practice, McGovern Medical School, The University of Texas Health Science Center, Houston and Children's Memorial Hermann Hospital, Houston, Texas. Electronic address:

Background: Parenteral nutrition for intestinal failure (IF) often requires a tunneled central venous catheter (CVC). The purpose of this study was to characterize complications after CVC placement and contributors to line loss in pediatric IF patients.

Methods: An institutional review board-approved retrospective review of pediatric (<18 y) IF patients who had a silicone tunneled CVC newly inserted or exchanged from 2012 to 2016 in an IF center was conducted. Read More

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November 2018

Applications of peptide hormone ligands for the treatment of dumping and short bowel syndrome.

Curr Opin Pharmacol 2018 Sep 28;43:118-123. Epub 2018 Sep 28.

Translational Research Center for Gastrointestinal Disorders (TARGID), University of Leuven, Herestraat 49, 3000 Leuven, Belgium; Leuven Intestinal Failure and Transplantation Center (LIFT), University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium. Electronic address:

Dumping syndrome is a common and debilitating complication of upper gastrointestinal surgery. Accelerated gastric emptying and dysregulated secretion of gastrointestinal (GI) hormones are involved in its pathophysiology. Pasireotide, a novel somatostatin analogue, improved dumping in a phase-2 study. Read More

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September 2018
3 Reads

Short article: Frequency, pathophysiology, and clinical classification of intestinal failure type II and III at a tertiary referral center.

Eur J Gastroenterol Hepatol 2019 01;31(1):123-127

Department of Clinical Nutrition, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City.

Objective: Intestinal failure (IF) is a complex disease that is gaining significance and attention throughout the world. In Mexico, there are no available data on this condition. The aim of this study was to determine the frequency and characteristics of patients with IF type II and III hospitalized at a tertiary referral center in our country. Read More

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January 2019

Comparison of polyglycolic acid, polycaprolactone, and collagen as scaffolds for the production of tissue engineered intestine.

J Biomed Mater Res B Appl Biomater 2018 Sep 30. Epub 2018 Sep 30.

Center for Perinatal Research, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio.

Cell-seeded scaffolds play critical roles in the production of tissue engineered intestine (TEI), a potential strategy for the treatment of short bowel syndrome. The current study compares polyglycolic acid (PGA), polycaprolactone (PCL), and collagen as scaffolds for TEI production. Tubular PGA scaffolds were prepared from nonwoven BIOFELT . Read More

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September 2018
6 Reads

Association of spontaneous labor onset with neonatal outcomes in pregnancies with fetal gastroschisis: A retrospective cohort analysis.

Acta Obstet Gynecol Scand 2018 Sep 28. Epub 2018 Sep 28.

Department of Obstetrics and Gynecology, Hospital das Clínicas, São Paulo University Medical School, Sao Paulo, Brazil.

Introduction: The present study aims to investigate the association of spontaneous labor onset with neonatal outcomes in pregnancies with fetal gastroschisis. The secondary goal was to evaluate the association between ultrasound markers and labor onset in pregnancies with fetal gastroschisis.

Material And Methods: A retrospective analysis was performed for 207 pregnancies with fetal gastroschisis between 2005 and 2017. Read More

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September 2018
3 Reads

Epidemiological study on intestinal volvulus without malrotation in VLBW infants.

Arch Dis Child Fetal Neonatal Ed 2018 Sep 27. Epub 2018 Sep 27.

Department of Neonatology, University Children's Hospital Tübingen, Tübingen, Germany.

Background: We conducted a monthly epidemiological survey in Germany to detect the prevalence of volvulus without malrotation (VWM) in very low birthweight (VLBW) infants and to identify factors for a better distinction between this rare and life-threatening event and other acute abdominal diseases in preterm infants.

Methods: Throughout 2014 and 2015, every paediatric department in Germany was asked to report cases of VWM in infants with birth weights <1500 g to the Surveillance Unit for Rare Paediatric Conditions in Germany. Hospitals reporting a case were asked to return an anonymised questionnaire and discharge letter. Read More

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September 2018
5 Reads

Adult Intestinal Botulism: A Rare Presentation in an Immunocompromised Patient With Short Bowel Syndrome.

Mayo Clin Proc Innov Qual Outcomes 2018 Sep 3;2(3):291-296. Epub 2018 Aug 3.

Division of Infectious Diseases, Mayo Clinic, Jacksonville, FL.

The cholinergic heat-labile neurotoxin produced by species is primarily responsible for the clinical manifestations of botulism. The classic phenotypic presentation of botulism consists of subacute descending flaccid paralysis with intact sensory function. Traditionally, it is classified into 3 main forms (foodborne, wound-related, and infantile) on the basis of primary site of toxin entry into the human nervous system. Read More

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September 2018
1 Read

Double plication for spring-mediated in-continuity intestinal lengthening in a porcine model.

Surgery 2018 Sep 11. Epub 2018 Sep 11.

Department of Surgery, Division of Pediatric Surgery, Stanford University School of Medicine, Stanford, California. Electronic address:

Background: Short bowel syndrome is a condition with substantial morbidity and mortality, yet definitive therapies are lacking. Distraction enterogenesis uses mechanical force to "grow" new intestine. In this study, we examined whether intestinal plication can be used to safely achieve spring-mediated intestinal lengthening in a functioning segment of jejunum in its native position. Read More

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September 2018
9 Reads

A Case of Chronic Calcium Oxalate Nephropathy due to Short Bowel Syndrome and Cholecystectomy.

Case Rep Nephrol Dial 2018 May-Aug;8(2):147-154. Epub 2018 Aug 10.

Department of Nephrology, Wakayama Medical University, Wakayama, Japan.

Background: Oxalate nephropathy is a rare disease. Especially chronic oxalate nephropathy still has many unknown aspects as compared to acute oxalate nephropathy with relatively well-known causality.

Case Presentation: The patient was a 70-year-old woman who had a history of small bowel resection 25 years before, cholecystectomy 10 years before, and renal stones (calcium oxalate stones) 7 years before. Read More

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August 2018
6 Reads

Surgical considerations for neonates with necrotizing enterocolitis.

Semin Fetal Neonatal Med 2018 Dec 20;23(6):420-425. Epub 2018 Aug 20.

Center for Advanced Intestinal Rehabilitation, Department of Surgery, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA. Electronic address:

Necrotizing enterocolitis (NEC) is a potentially devastating condition that preferentially affects premature and low birth weight infants, with approximately half requiring acute surgical intervention. Surgical consult should be considered early on, and deterioration despite maximal medical therapy or the finding of pneumoperitoneum are the strongest indications for emergent surgical intervention. There is no clear consensus on the optimal surgical approach between peritoneal drainage and laparotomy; the best course of action likely depends on the infant's comorbidities, hemodynamic status, size, disease involvement, and available resources. Read More

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December 2018
8 Reads

Intestinal failure in adults: Recommendations from the ESPEN expert groups.

Clin Nutr 2018 Dec 18;37(6 Pt A):1798-1809. Epub 2018 Aug 18.

Gastrointestinal Surgery, Nottingham Digestive Diseases Centre, National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre, Nottingham University Hospitals and University of Nottingham, Queen's Medical Centre, Nottingham NG7 2UH, UK.

Background & Aims: Intestinal failure (IF) is defined as "the reduction of gut function below the minimum necessary for the absorption of macronutrients and/or water and electrolytes, such that intravenous supplementation is required to maintain health and/or growth". Functionally, it may be classified as type I acute intestinal failure (AIF), type II prolonged AIF and type III chronic intestinal failure (CIF) The ESPEN Workshop on IF was held in Bologna, Italy, on 15-16 October 2017 and the aims of this document were to highlight the current state of the art and future directions for research in IF.

Methods: This paper represents the opinion of experts in the field, based on current evidence. Read More

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December 2018
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Experience with teduglutide treatment for short bowel syndrome in clinical practice.

Clin Nutr 2018 Aug 2. Epub 2018 Aug 2.

Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Medical Department, Division of Hepatology and Gastroenterology, Berlin, Germany. Electronic address:

Background & Aims: Teduglutide, a glucagon-like peptide 2 (GLP-2) analog, is an approved medication specific for short bowel syndrome patients with chronic intestinal failure (SBS-IF). Due to its intestinotrophic properties, it improves intestinal absorption of fluids and nutrients, which was shown to reduce the need for parenteral support in clinical trials. The present report aims to describe the experience of teduglutide's effects in routine medical care with focus on clinical and nutritional effects. Read More

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August 2018
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Milk Fat Globule Membrane Inhibits NLRP3 Inflammasome Activation and Enhances Intestinal Barrier Function in a Rat Model of Short Bowel.

JPEN J Parenter Enteral Nutr 2018 Aug 24. Epub 2018 Aug 24.

Department of Clinical Nutrition, Xin Hua Hospital affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Background: The milk fat globule membrane (MFGM) contains various bioactive components which have been shown to maintain gut barrier integrity. This study aimed to evaluate the protective effects of MFGM on intestinal barrier function and its possible mechanisms in a rat model of short bowel syndrome (SBS).

Materials And Methods: Five-week-old male Sprague-Dawley rats were divided into 3 groups (n = 8 per group), consisting of Sham group and rats submitted to massive small-bowel resection then supplemented with either water (SBS) or 1. Read More

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August 2018
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Soluble Mediators From Lactobacillus rhamnosus Gorbach-Goldin Support Intestinal Barrier Function in Rats After Massive Small-Bowel Resection.

JPEN J Parenter Enteral Nutr 2018 Aug 9;42(6):1026-1034. Epub 2018 Jan 9.

Department of Clinical Nutrition, Xin Hua Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Background: Intestinal barrier plays an essential role in maintaining gastrointestinal health. This study aimed to explore the effects of a soluble mediator preparation derived from Lactobacillus rhamnosus Gorbach-Goldin (LGG) on intestinal barrier function in a rat model of short bowel syndrome (SBS).

Methods: Six-week-old male Sprague-Dawley rats underwent 80% small-bowel resection (SBR) and then were supplemented with water (SBS), 5 × 10 colony-forming unit viable LGG (SBS+LGG), or the LGG soluble mediators (SBS+LSM) in an equivalent dose to LGG by intragastric gavage daily from day 2 throughout day 14 after operation. Read More

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August 2018
9 Reads