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J Pak Med Assoc 2022 Jun;72(6):1222-1224

Department of General Surgery, Mayo Hospital, Lahore, Pakistan.

Acute mesenteric ischaemia is one of the serious abdominal surgical emergency, which has got very high morbidity and mortality. During the pandemic of COVID-19, besides respiratory complications, the virus was causing venous and arterial thromboembolism that can lead to acute mesenteric ischaemia in otherwise healthy individuals. Early diagnosis and suitable surgical procedures are the key to the better outcome of this disease. Read More

Andes Pediatr 2022 Apr;93(2):192-198

Hospital San Juan de Dios, Santiago, Chile.

Intestinal Failure (IF) includes the loss of functional intestinal mass and the requirement of long term Parenteral Nutrition (PN) to achieve the development and growth in childhood.

Objective: To evaluate the experience in a specialized unit for pediatric patients with IF, describing the clinical cha racteristics of those admitted from November 2009 to December 2019.

Patients And Method: Retros pective and descriptive review from clinical records of 24 cases that matched the inclusion criteria. Read More

J Pediatr Gastroenterol Nutr 2022 Jun 22. Epub 2022 Jun 22.

Institute of Gastroenterology Nutrition and Liver Diseases, Schneider Children's Medical Center of Israel, Petach-Tikva, Israel.

Objectives: The Glucagon-like peptide-2 analog Teduglutide has been shown to enhance intestinal absorption and decrease parenteral nutrition (PN) requirements in short bowel syndrome (SBS). As data in children is limited, we evaluated nationwide real-life experience and treatment outcome in children with SBS.

Methods: Longitudinal data of children treated with Teduglutide for ≥3 months was collected. Read More

Am J Clin Nutr 2022 Jun 21. Epub 2022 Jun 21.

Food & Mood Centre, Institute for Mental and Physical Health and Clinical Translation (IMPACT), Deakin University, Victoria, Australia.

Background: A low FODMAP (fermentable oligosaccharides, disaccharides, monosaccharides and polyols) diet is increasingly used to manage symptoms in irritable bowel syndrome (IBS). While this approach may alter the colonic microbiome, the nature of these changes has not been comprehensively synthesized.

Objectives: The aim of this study was to conduct a systematic review with meta-analysis of randomized controlled trials (RCTs) examining the impact of a low FODMAP diet on the composition and function of the microbiome in patients with IBS. Read More

Am J Physiol Gastrointest Liver Physiol 2022 Jun 21. Epub 2022 Jun 21.

Division of Pediatric Surgery, Department of Surgery, Washington University School of Medicine, St. Louis Children's Hospital, St. Louis, MO, United States.

Background: The unfolded protein response (UPR) is a complex adaptive signaling pathway activated by accumulation of misfolded proteins in the endoplasmic reticulum (ER). ER stress (ERS) triggers a cascade of responses that converge upon C/EBP-homologous protein (CHOP) to drive inflammation and apoptosis. Herein, we sought to determine whether liver injury and fibrosis after small bowel resection (SBR) was mediated by a maladaptive hepatic ERS/UPR. Read More

Semin Pediatr Surg 2022 Jun 14;31(3):151175. Epub 2022 May 14.

Division of General and Thoracic Surgery, Cincinatti Children's Hospital Medical Center, University of Cincinnati, Cincinnatii, USA; Cincinnati Children's Intestinal Rehabilitation Program, Cincinnati Children's Hospital Medical Center, University of Cincinnati, 3333 Burnet Avenue, MLC 2023, Cincinnati, Ohio 45229, USA. Electronic address:

Intestinal failure (IF) secondary to short bowel syndrome is a challenging and complex medical condition with significant risk for surgical and medical complications. Significant advancements in the care of this patient population have led to improved survival rates. Due to their intensive medical needs children with IF are at risk for long-term complications that require comprehensive management and close monitoring. Read More

Front Pediatr 2022 2;10:917116. Epub 2022 Jun 2.

Department of Neonatal Surgery, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.

Meconium peritonitis (MP) combined with intestinal atresia (IA) is a rare neonatal condition, and it is even rarer in combination with biliary atresia (BA). We describe a case of an infant who developed short bowel syndrome after partial intestinal resection due to MP and IA, along with a Santullienterostomy. During continuous enteral and parenteral nutrition, the stool color became paler. Read More

Dis Colon Rectum 2021 Dec 13. Epub 2021 Dec 13.

Department of Surgery, Anorectal Physiology Laboratory, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.

Background: The exact relation between anastomotic height after rectal cancer surgery and postoperative bowel function problems has not been investigated in the long term, causing ineffective treatment.

Objective: To determine the effect of anastomotic height on long-term bowel function and generic quality of life.

Design: A multicenter cross-sectional study. Read More

Medicine (Baltimore) 2022 Jun 17;101(24):e29464. Epub 2022 Jun 17.

General Surgery Department, IRCCS MultiMedica, Italy.

Introduction: Neuroendocrine tumours (NETs) are rare tumors. 55% of NETs originate in the gastrointestinal tract and the liver is the most common site of distant metastases. Serum chromogranin A is the most common biomarker for assessing the extent of disease and monitoring treatment; carcinoid syndrome occurs in 19% of NETs and is characterized by chronic diarrhea or flushing. Read More

Wideochir Inne Tech Maloinwazyjne 2022 Jun 25;17(2):365-371. Epub 2022 Mar 25.

Department of Internal Medicine and Geriatric Cardiology, Medical Centre of Postgraduate Education, Orłowski Hospital, Warsaw, Poland.

Introduction: Single anastomosis sleeve ileal (SASI) bypass is a recently introduced bariatric procedure that combines the advantages of restrictive and malabsorptive operations, at the same time reducing the risk of nutrient deficiencies by maintaining passage through all the alimentary tract.

Aim: To present the outcomes of the first group of patients that underwent the SASI bypass in our clinic and assess the safety and efficiency of the procedure.

Material And Methods: We analyzed patients qualified for SASI bypass between January 2020 and February 2021. Read More

Rev Esp Enferm Dig 2022 Jun 15. Epub 2022 Jun 15.

Gastroenterología y Hepatología Pediátrica, Hospital Universitari i Politècnic La Fe, España.

A 15-year-old boy was admitted to the hospital due to ataxia, drowsiness and bradypsychia. He was known to have a short bowel syndrome Initial venous blood gases revealed a metabolic acidosis with a high anion gap of 24 mmol/L and normal L-lactate. He improved with fasting and fluids and was discharged with oral metronidazole. Read More

Clin Gastroenterol Hepatol 2022 Jun 11. Epub 2022 Jun 11.

Division of Gastroenterology, Hepatology, and Nutrition; Digestive Disease and Surgery Institute; Cleveland Clinic, Cleveland, OH, USA.

Am J Clin Oncol 2022 07 25;45(7):298-305. Epub 2022 May 25.

Departments of Radiation Oncology & Molecular Radiation Sciences.

Purpose: The purpose of his study was to report on a cohort of patients managed with nonoperative management (NOM) with a watch-and-wait strategy after achieving complete response (CR) to sequential short-course radiation therapy (SCRT) and consolidation chemotherapy.

Methods: This was a retrospective study of patients treated SCRT and chemotherapy who achieved a CR and were managed with NOM. Bowel function was assessed with European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire Core 30, EORTC Quality of Life Questionnaire-Colorectal Cancer 29, and the low anterior resection syndrome (LARS) questionnaires. Read More

J Med Internet Res 2022 06 10;24(6):e35260. Epub 2022 Jun 10.

College of Nursing, Research Institute of Nursing Science, Seoul National University, Seoul, Republic of Korea.

Background: Irritable bowel syndrome is a common functional gastrointestinal disorder that negatively affects all aspects of life. With the widespread use of the internet, internet-delivered cognitive behavioral therapy has been developed and applied to control symptoms and improve the quality of life of those with irritable bowel syndrome. However, few studies have systematically reviewed the effectiveness of internet-delivered cognitive behavioral therapy on irritable bowel syndrome. Read More

BJS Open 2022 May;6(3)

Division of Surgery, Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden.

Background: Metabolic (bariatric) surgery for patients with severe obesity and pre-existing heart disease has been reported to reduce the risk for cardiovascular events and mortality; however, concerns of short- and mid-term complications may limit the utility of metabolic surgery for these patients.

Method: This was an observational, nationwide, matched study, including all adult patients operated with a primary gastric bypass or sleeve gastrectomy procedure in Sweden from January 2011 until October 2020. Patients with or without previous acute coronary syndrome or heart failure were matched 1:5 using propensity scores. Read More

J Pediatr Gastroenterol Nutr 2022 Jun 7. Epub 2022 Jun 7.

Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, Texas 77030.

This was a retrospective study that compared outcomes in pediatric intestinal failure (IF) patients that were switched from ethanol lock therapy (ELT) to sodium bicarbonate lock therapy (SBLT). The primary outcome was rate of catheter-related blood stream infections (CRBSI). The secondary outcomes were number of hospitalizations, ER visits, central venous catheter (CVC) -related complications. Read More

J Pediatr 2022 Jun 1. Epub 2022 Jun 1.

Group for Improvement of Intestinal Function and Treatment (GIFT), The Hospital for Sick Children, Toronto, ON; Institute for Health Policy, Management and Evaluation, University of Toronto, Toronto, ON; Surgical Director, Intestinal Rehabilitation, Cincinnati Children's Hospital, Cincinnati, OH. Electronic address:

Objective: To measure the time that caregivers spend on tasks related to providing care to their child with IF receiving home parenteral nutrition (PN).

Methods: An exploratory cross-sectional study of caregivers of children with IF on long-term PN followed by our intestinal rehabilitation program. Caregivers completed a daily diary of care-related tasks. Read More

Clin Perinatol 2022 06 21;49(2):557-572. Epub 2022 Apr 21.

Global Newborn Society (https://www.globalnewbornsociety.org/), Clarksville, MD, USA.

Short bowel syndrome (SBS) of infancy is a cause of prolonged morbidity with intolerance to enteral feeding, specialized nutritional needs, and partial/total dependence on parenteral nutrition. These infants can benefit from individualized nutritional strategies to support and enhance the process of intestinal adaptation. Early introduction of enteral feeds during the period of intestinal adaptation is crucial, even though the enteral feedings may need to be supplemented with an effective, safe, and nutritionally adequate parenteral nutritional regimen. Read More

Clin Perinatol 2022 06 21;49(2):521-536. Epub 2022 Apr 21.

Associate Professor, Division of Neonatology, Department of Pediatrics, Baylor College of Medicine, Texas Children's Hospital, 6621 Fannin, Suite 6104, Houston, TX 77030, USA. Electronic address:

Due to recent advances, the mortality due to short bowel syndrome (SBS) has significantly decreased, but the morbidities are still high. Morbidities arising specifically due to dysmotility in SBS include feeding intolerance, prolonged dependence on parenteral nutrition, and associated complications such as intestinal failure associated liver disease, and bloodstream infections. The understanding of the pathogenesis of dysmotility in SBS has improved vastly. Read More

BMC Surg 2022 Jun 3;22(1):214. Epub 2022 Jun 3.

Second Affiliated Hospital of Soochow University, Suzhou, China.

Background: Nonocclusive mesenteric ischemia (NOMI) is defined as acute intestinal ischemia because of decreased blood flow in mesenteric vessels. Only a few cases of NOMI that occur secondary to aortic dissection (AD) have been reported, resulting in the lack of sufficient knowledge of diagnosis and treatment.

Case Presentation: We aimed to report a case of NOMI caused by type B Aortic Dissection. Read More

Gut Microbes 2022 Jan-Dec;14(1):2083417

Division of Gastroenterology and Hepatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Complications of short bowel syndrome (SBS) include malabsorption and bacterial overgrowth, requiring prolonged dependence on parenteral nutrition (PN). We hypothesized that the intolerance of whole food in some SBS patients might be due to the effect of dietary fiber on the gut microbiome. Shotgun metagenomic sequencing and targeted metabolomics were performed using biospecimens collected from 55 children with SBS and a murine dietary fiber model. Read More

Int J Surg Case Rep 2022 May 1;94:107107. Epub 2022 May 1.

Des Moines University, Des Moines, IA, United States of America; Broadlawns Medical Center, Des Moines, IA, United States of America; University of Iowa, Iowa City, IA, United States of America. Electronic address:

Introduction And Importance: Short bowel syndrome is characterized by maldigestion and malabsorption resulting in deficiencies of multiple nutrients including vitamins and minerals. Most subjects required parental elimination for survival. GLP-2 RA Teduglutide was recently approved for treatment of short bowel syndrome especially for those requiring parenteral support. Read More

Front Pediatr 2022 17;10:846630. Epub 2022 May 17.

Department of Pediatric Surgery, University Children's Hospital Mannheim, University of Heidelberg, Mannheim, Germany.

Objective: In patients with a congenital diaphragmatic hernia (CDH), postoperative small bowel obstruction (SBO) is a life-threatening event. Literature reports an incidence of SBO of 20% and an association with patch repair and ECMO treatment. Adhesions develop due to peritoneal damage and underly various biochemical and cellular processes. Read More

Dig Liver Dis 2022 May 30. Epub 2022 May 30.

Department NEUROFARBA. University of Florence. Meyer Children's Hospital, viale Gaetano Pieraccini 24, Florence, Italy.

In recent years, the spectrum of possible treatments for Intestinal Failure (IF)-Short Bowel Syndrome (SBS) has been enriched by the implementation of GLP-2 analogues. In Italy, teduglutide (Ted), an analogue of GLP-2, was approved in January 2021 by the Italian Regulatory Agency for Drugs (AIFA) for IF-SBS patients ≥1 year old. According to the Agency indications, Ted can now be prescribed by regional reference centers, with costs fully charged to the National Health Service. Read More

Ulus Travma Acil Cerrahi Derg 2022 Jun;28(6):879-883

Department of General Surgery, Trakya University Faculty of Medicine, Edirne-Turkey.

Peutz-Jeghers Syndrome (PJS) is a rare autosomal dominant disorder which is characterized by hyperpigmentation in mucocutaneous membranes and hamartomatous polyps in the gastrointestinal tract (GIT). Common complications reported in patients with PSJ are bleeding and mechanical intestinal obstruction due to the hamartomatous polyps. There is also an increased risk of gastrointestinal and extra-intestinal malignancies in patients with PJS. Read More

Front Surg 2022 16;9:881782. Epub 2022 May 16.

Division of Pediatric Gastroenterology and Nutrition; Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Background: Type I short bowel syndrome (SBS) occurs after a critical reduction in the functional gut mass and resection of intestinal continuity after ileostomy or jejunostomy for necrotizing enterocolitis (NEC), intestinal atresia or other causes. SBS is often accompanied with intestinal failure-associated liver disease (IFALD) who requires long-term parenteral nutrition (PN). Our study aimed to observe the effect of intestinal continuity on the hepatic function of pediatric intestinal failure (IF) patients with type I SBS. Read More

Nutr Clin Pract 2022 May 31. Epub 2022 May 31.

Division of Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.

Background: Blenderized feeds consisting of whole food components are emerging as a preferred approach to enteral nutrition. However, there is limited evidence-based guidance for this strategy in short bowel syndrome (SBS). We aimed to explore the tolerance and clinical outcome of blenderized feeds in patients with SBS. Read More

Aust J Gen Pract 2022 Jun;51(6):395-400

PhD, Registered Nutritionist, Senior Lecturer and Researcher, Department of Nutrition, Dietetics and Food, Monash University, Melbourne, Vic.

Background: Irritable bowel syndrome (IBS) is a disorder of the gut-brain axis with a prevalence of 3.5% in Australia. The complexity of mechanisms underlying IBS means patients often respond poorly to treatment. Read More

Int J Vitam Nutr Res 2022 May 30. Epub 2022 May 30.

Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan.

Gut microbiota and short-chain fatty acids (SCFAs) are recognized as key factors in the pathophysiology of irritable bowel syndrome. Astaxanthin is a carotenoid with strong antioxidant and anti-inflammatory activities. In this study, we examined the effects of astaxanthin on gut microbiota-, SCFAs-, and corticotropin-releasing factor (CRH)-induced intestinal hypermotility. Read More

Front Nutr 2022 11;9:810453. Epub 2022 May 11.

Department of Food Science and Engineering, Ningbo University, Ningbo, China.

In recent years, the relevant research on intestinal flora has been in full swing, and it has become an extremely important research direction in clinical medicine and life science. Irritable bowel syndrome (IBS) is a common disease characterized by changes in intestinal function and accompanied by comorbid anxiety. At present, the pathogenic mechanism of IBS is not yet clear. Read More