5,261 results match your criteria Shock and Pregnancy


A rare case of group A streptococcal toxic-shock syndrome in a postpartum adolescent leading to multi-organ failure.

Clin Case Rep 2020 May 16;8(5):793-797. Epub 2020 Mar 16.

Department of Pediatric Critical Care Medicine University of Kansas Medical Center Kansas City KS USA.

Teenage pregnancy is not uncommon, but given the age of the patient, experience, and competency among medical providers varies. While toxic-shock syndrome from group A streptococcus is rare in teenage pregnancy, observed is a gap in care of bridging. Read More

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http://dx.doi.org/10.1002/ccr3.2799DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250980PMC

Systematic Review of Postfertilization Effects and Potential for Embryo Formation and Loss during the Use of Intrauterine Devices.

Linacre Q 2020 Feb 27;87(1):60-77. Epub 2019 Jun 27.

Department of Obstetrics, Gynecology, and Women's Health, Saint Louis University, St. Louis, MO, USA.

Objectives: This review sought to evaluate the evidence for embryo formation during intrauterine device (IUD) use, to articulate how often embryo loss occurs in well-designed studies, and to comment on other bodies of literature suggestive of postfertilization mechanisms of action of IUDs.

Methods: The MEDLINE, EMBASE, and Ovid databases were searched for English-language studies of markers of pregnancy in IUD users in May 2018. Studies of human chorionic gonadotropin (hCG) were subjected to quality assessment based on the US Preventive Services Task Force quality tool. Read More

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http://dx.doi.org/10.1177/0024363919854289DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016440PMC
February 2020

Caval Aortic Index: A Novel Tool for Fluid Assessment in Obstetric Emergencies.

J Emerg Trauma Shock 2020 Jan-Mar;13(1):50-53. Epub 2020 Mar 19.

Department of Anesthesiology, Jubilee Mission Medical College and Research Institute, Thrissur, Kerala, India.

Background: Uncorrected maternal hypotension occurring during obstetric emergencies may result in maternal and fetal morbidity. Fluid status of the pregnant mother is a major variable which affects the maternal hemodynamics during patient management, and there is no objective assessment tool for the same. A relatively new sonographic parameter, the inferior vena cava aorta (IVC/Ao) diameter index or caval aortic index, showed promise in this regard, and its application was studied in obstetric patients. Read More

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http://dx.doi.org/10.4103/JETS.JETS_136_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204966PMC

Clinical course of severe and critical COVID-19 in hospitalized pregnancies: a US cohort study.

Am J Obstet Gynecol MFM 2020 May 8:100134. Epub 2020 May 8.

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Sidney Kimmel Medical College of Thomas Jefferson University, Philadelphia, PA, USA.

Background: The COVID-19 pandemic has had an impact on healthcare systems around the world with 3.0 million infected and 208,000 resultant mortalities as of this writing. Information regarding infection in pregnancy is still limited. Read More

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http://dx.doi.org/10.1016/j.ajogmf.2020.100134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205698PMC

Reduced ovarian response to controlled ovarian stimulation is associated with increased oxidative stress in the follicular environment.

Reprod Biol 2020 May 5. Epub 2020 May 5.

Department of Clinical Embryology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal 576 104, India. Electronic address:

Serum estradiol (E2) level is routinely used to monitor the ovarian response during controlled ovarian hyperstimulation (COH) and the concentration of serum E2 may influence the oocyte quality and pregnancy outcome. However, the knowledge on the association between COH induced serum E2 level, oocyte quality and embryo development is limited. Therefore we investigated the association between serum E2 level, oxidative stress in the follicular fluid and granulosa cells (GCs) response to elucidate the association between E2 level and embryological outcome. Read More

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http://dx.doi.org/10.1016/j.repbio.2020.04.005DOI Listing

Mental health nursing and the prenatal diagnosis of a congenital anomaly; a narrative of experience.

J Psychiatr Ment Health Nurs 2020 May 4. Epub 2020 May 4.

School of Health and Human Services, Southern Cross University, Lismore, NSW, Australia.

What Is Known On The Subject: Many parents find out that their unborn baby has a difference in their health, development, or genetics. This news is often unexpected and can be distressing and traumatic, which can lead to anxiety. There is a gap in support for parents. Read More

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http://dx.doi.org/10.1111/jpm.12645DOI Listing

A systematic review regarding women's emotional and psychological experiences of high-risk pregnancies.

BMC Psychol 2020 May 3;8(1):45. Epub 2020 May 3.

Department of Psychology, University of the Western Cape, Cape Town, South Africa.

Background: High-risk pregnancy refers to a pregnancy that negatively affects the health of the mother, the baby, or both. High-risk pregnancy evokes a range of emotional and psychological experiences for the expectant mother, and can adversely affect both the mother and the baby's health. Medical research on high-risk pregnancy abounds, while women's emotional/psychological experiences are not sufficiently documented, and hence much less attention and/or programming is directed to support women with high risk pregnancies. Read More

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http://dx.doi.org/10.1186/s40359-020-00410-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7197168PMC

[Heat shock protein 90 (HSP90) in age-dependent changes in the number of fibroblasts in human skin.]

Adv Gerontol 2020 ;33(1):40-45

I.N.Ulianov Chuvash State University, 15 Moscowski pr., Cheboksary 428015, Russian Federation, e-mail:

The aim of this work was to examine the content of heat shock protein 90 (HSP90) in fibroblasts of human dermis from the development until deep aging (from 20 weeks of pregnancy until 85 years old), and defining of a role of HSP90 in age-dependent changes in the number of fibroblasts in the dermis. HSP90, proliferating cells nuclear antigen (PCNA) were detected with indirect immunohistochemical technique. Results showed that a portion of fibroblasts with positive staining for HSP90 in the dermis is not changed from 20 weeks of development to 20 years old. Read More

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January 2020

Couples experiences of receiving uncertain results following prenatal microarray or exome sequencing: A mixed-methods systematic review.

Prenat Diagn 2020 May 2. Epub 2020 May 2.

London North Genomic Laboratory Hub, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.

Background: Tests in pregnancy such as chromosomal microarray analysis and exome sequencing are increasing diagnostic yield for fetal structural anomalies, but have greater potential to result in uncertain findings. This systematic review investigated the experiences of prospective parents about receiving uncertain results from these tests.

Methods: A systematic search of three electronic databases was conducted. Read More

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http://dx.doi.org/10.1002/pd.5729DOI Listing

Pro-inflammatory mediators in vaginal fluid and short cervical length in pregnancy.

Bratisl Lek Listy 2020 ;121(4):278-281

Aim: We hypothesized that elevated vaginal levels of matrix metalloproteinase-8 (MMP-8), interleukin-8 (IL-8) and the 70kDa heat shock protein (hsp70), compounds involved in inflammatory responses, correlated with a short cervix in pregnant women.

Methods: This prospective cohort study used a convenience sample of 64 women in their early third trimester with a singleton pregnancy. A short cervical length was present in 35 women (54. Read More

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http://dx.doi.org/10.4149/BLL_2020_042DOI Listing
January 2020

Thrombolysis in massive and submassive pulmonary embolism during pregnancy and the puerperium: a systematic review.

J Thromb Thrombolysis 2020 Apr 28. Epub 2020 Apr 28.

Escuela de Medicina y Ciencias de La Salud, Tecnologico de Monterrey, Monterrey, Nuevo Leon, Mexico.

Thrombolysis in high-risk pulmonary embolism (PE) patients is recommended worldwide; however, the evidence for thrombolysis during pregnancy and the immediate puerperium remains unclear. We conducted a systematic review from 1950 to 2019 through PubMed, Ovid/Willey, and Cochrane Library to assess the safety and effectiveness of thrombolysis during pregnancy and the immediate puerperium. Additionally, we characterized the clinical presentation, risk stratification, and diagnostic approach. Read More

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http://dx.doi.org/10.1007/s11239-020-02122-7DOI Listing

Extracorporeal membrane oxygenation in peripartum cardiomyopathy: A review of the ELSO Registry.

Int J Cardiol 2020 Mar 3. Epub 2020 Mar 3.

Section of Critical Care Medicine, Department of Pediatrics, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, USA.

Aims: Data on the use of extracorporeal membrane oxygenation (ECMO) for cardiogenic shock in peripartum cardiomyopathy (PPCM) is limited. We queried the Extracorporeal Life Support Organization (ELSO) Registry for PPCM patients treated with ECMO in order to characterize demographic and clinical features, complications, survival, and variables associated with mortality.

Methods And Results: This was a retrospective review of patients voluntarily entered into the ELSO Registry. Read More

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http://dx.doi.org/10.1016/j.ijcard.2020.03.006DOI Listing

Maternal and Neonatal Outcomes during Dengue Infection Outbreak at a Tertiary National Hospital in Endemic Area of Indonesia.

Korean J Fam Med 2020 May 21;41(3):161-166. Epub 2020 Apr 21.

Obstetrics and Gynecology Residency, Obstetrics and Gynecology Department, Udayana University and Sanglah Hospital, Denpasar, Indonesia.

Background: Dengue infection is the most common mosquito-borne disease in Indonesia. Dengue incidence during pregnancy increases with its prevalence among women of reproductive ages. It potentially causes serious maternal and neonatal morbidity and mortality; however, its impact during a period of disease outbreak has not been described. Read More

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http://dx.doi.org/10.4082/kjfm.18.0154DOI Listing

Bisexual Fertile Triploid Zebrafish (Danio rerio): a Rare Case.

Mar Biotechnol (NY) 2020 Jun 20;22(3):443-455. Epub 2020 Apr 20.

State Key Laboratory of Developmental Biology of Freshwater Fish, Hunan Normal University, Changsha, 410081, Hunan, People's Republic of China.

Previous studies have suggested that artificially induced triploid zebrafish are exclusively male-biased. Owing to greatly inhibited gonadal development for the artificially induced triploid fish, they are regarded to be sterile in general. In this article, partially fertile bisexual triploid zebrafish are produced by suppressing extrusion of the second polar body by heat shock. Read More

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http://dx.doi.org/10.1007/s10126-020-09964-5DOI Listing

Risk Factors for Neonatal/Maternal Morbidity and Mortality in African American Women with Placental Abruption.

Medicina (Kaunas) 2020 Apr 13;56(4). Epub 2020 Apr 13.

Department of Obstetrics and Gynecology, New York Health and Hospitals/Lincoln, Bronx, NY 10451, USA.

: Risk factors for neonatal/maternal morbidity and mortality in placental abruption have been incompletely studied in the current literature. Most of the research overlooked the African American population as mostly Caucasian populations are selected. We aimed to find which risk factor influence the neonatal and maternal outcome in cases of placental abruption occurring in African American pregnant women in an inner-city urban setting. Read More

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http://dx.doi.org/10.3390/medicina56040174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230772PMC

A Comparison of the Characteristics of Maternal Near-Misses and Maternal Deaths in Enugu, Southeast Nigeria: A 3-Year Prospective Study.

Int J Womens Health 2020 26;12:207-211. Epub 2020 Mar 26.

Department of Obstetrics and Gynaecology, College of Medicine, University of Nigeria, Nsukka, Nigeria.

Background: Maternal near-misses, also known as severe acute maternal morbidity, have become globally recognized as an appropriate indicator of obstetric care. Women experiencing maternal near-misses are more in number than maternal deaths, and can provide more specific and detailed evidence, as the patient herself can be a leading source of useful information.

Objective: To determine the frequency of maternal near-misses and maternal deaths in the University of Nigeria Teaching Hospital in Ituku-Ozalla, Enugu, document the primary determinant factor that caused these, and compare cases of maternal near-miss and maternal deaths. Read More

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http://dx.doi.org/10.2147/IJWH.S237221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105884PMC

Pregnancy with Fontan circulation: A report of case series in Japan.

J Cardiol Cases 2020 Apr 30;21(4):161-163. Epub 2019 Dec 30.

Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.

Owing to new surgical procedures and medications, more women who have undergone the Fontan procedure reach childbearing ages. We report five cases of pregnancy with Fontan circulation. Case 1 had subchorionic hematoma (SCH), fetal growth restriction (FGR), and preterm labor (PTL). Read More

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http://dx.doi.org/10.1016/j.jccase.2019.12.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125375PMC

Equine hydrallantois is associated with impaired angiogenesis in the placenta.

Placenta 2020 Apr 5;93:101-112. Epub 2020 Mar 5.

Gluck Equine Research Center, Department of Veterinary Science, University of Kentucky, Lexington, KY, USA. Electronic address:

Introduction: Hydrallantois is the excessive accumulation of fluid in the allantoic cavities during the last trimester of pregnancy, leading to abdominal wall hernias, cardiovascular shock, abortion, and dystocia. It has been postulated that hydrallantois is associated with structural and/or functional changes in the chorioallantoic membrane. In the present study, we hypothesized that angiogenesis is impaired in the hydrallantoic placenta. Read More

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http://dx.doi.org/10.1016/j.placenta.2020.03.001DOI Listing

Probenecid treatment improves outcomes in a novel mouse model of peripartum cardiomyopathy.

PLoS One 2020 27;15(3):e0230386. Epub 2020 Mar 27.

Division of Cardiovascular Health & Disease, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America.

Probenecid has been used for decades in the treatment of gout but recently has also been found to improve outcomes in patients with heart failure via stimulation of the transient receptor potential vanilloid 2 (TRPV2) channel in cardiomyocytes. This study tested the use of probenecid on a novel mouse model of peripartum cardiomyopathy (PPCM) as a potential treatment option. A human mutation of the human heat shock protein 20 (Hsp20-S10F) in mice has been recently shown to result in cardiomyopathy, when exposed to pregnancies. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0230386PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7100971PMC

Ethnic Violence and Birth Outcomes: Evidence From Exposure to the 1992 Conflict in Kenya.

Demography 2020 Apr;57(2):423-444

National Graduate Institute for Policy Studies (GRIPS), 7-22-1 Roppongi, Minato-ku, Tokyo, 106-8677, Japan.

This study is an examination of the effect of intrauterine exposure to electoral violence on child birth weight, an outcome that has long-term effects on an individual's education, income, and health in later life. We consider the electoral violence that resulted from the introduction of multiparty democracy in Kenya as an exogenous source of shock, using a difference-in-differences method and a mother fixed-effects model. We find that prenatal exposure to the violence increased the probabilities of low birth weight and a child being of very small size at birth by 19 and 6 percentage points, respectively. Read More

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http://dx.doi.org/10.1007/s13524-020-00864-wDOI Listing

Female Genital Mutilation/Cutting as Grounds for Asylum Requests in the US: An Analysis of More than 100 Cases.

J Immigr Minor Health 2020 Mar 18. Epub 2020 Mar 18.

Asylum Program, Physicians for Human Rights, New York, NY, USA.

Female Genital Mutilation or Cutting (FGM/C) is a human rights violation used to claim asylum in the US. We sought to understand the nature of these asylum requests. Analysis of 121 FGM/C-focused medical affidavits, and 132 legal case reports. Read More

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http://dx.doi.org/10.1007/s10903-020-00994-8DOI Listing

Long-Term Outcome of Thrombolytic Therapy for Massive Pulmonary Embolism in Pregnancy.

Case Rep Cardiol 2020 19;2020:9153618. Epub 2020 Feb 19.

Department of Internal Medicine Faculty of Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Vietnam.

A 25-year-old pregnant woman presented at 12 weeks of gestation with syncope and shortness of breath caused by massive pulmonary embolism. Due to persistent shock, fibrinolytic therapy with rtPA was administered. After fibrinolysis, clinical and hemodynamic response was excellent. Read More

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http://dx.doi.org/10.1155/2020/9153618DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053479PMC
February 2020

Perspectives of pregnant and postpartum women and obstetric providers to promote healthy lifestyle in pregnancy and after delivery: a qualitative in-depth interview study.

BMC Womens Health 2020 Mar 4;20(1):44. Epub 2020 Mar 4.

Department of Medicine, Division of General Internal Medicine, The Johns Hopkins University School of Medicine, 2024 E. Monument St, Suite 2-616, Baltimore, MD, 21205, USA.

Background: Pregnancy provides an opportunity to promote healthy lifestyle behaviors. This study's aim was to explore the perspectives of pregnant and postpartum women and obstetric providers around behavioral lifestyle changes in pregnancy and postpartum.

Methods: We conducted a qualitative study with pregnant and postpartum patients recruited from 2 prenatal care clinics at an urban, academic hospital in the United States. Read More

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http://dx.doi.org/10.1186/s12905-020-0896-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7057562PMC

Damage-control resuscitation in obstetrics.

J Matern Fetal Neonatal Med 2020 Feb 26:1-14. Epub 2020 Feb 26.

High Complexity Obstetric Unit, Department of Obstetrics and Gynecology, Fundación Valle del Lili, Cali, Colombia.

Severe obstetric hemorrhage is a catastrophic event and represents the main cause of maternal morbidity and mortality worldwide. The elevated mortality rate due to hemorrhage is associated with metabolic complications and organ hypoperfusion that may trigger a state of irreversible coagulopathy. Thus, the use of conventional measures to control bleeding frequently generates a vicious cycle in which the patient continues bleeding (prolonging surgical times). Read More

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http://dx.doi.org/10.1080/14767058.2020.1730800DOI Listing
February 2020

Targeting the Stress System During Gestation: Is Early Handling a Protective Strategy for the Offspring?

Front Behav Neurosci 2020 31;14. Epub 2020 Jan 31.

Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties "Giuseppe D'Alessandro", University of Palermo, Palermo, Italy.

The perinatal window is a critical developmental time when abnormal gestational stimuli may alter the development of the stress system that, in turn, influences behavioral and physiological responses in the newborns. Individual differences in stress reactivity are also determined by variations in maternal care, resulting from environmental manipulations. Despite glucocorticoids are the primary programming factor for the offspring's stress response, therapeutic corticosteroids are commonly used during late gestation to prevent preterm negative outcomes, exposing the offspring to potentially aberrant stress reactivity later in life. Read More

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http://dx.doi.org/10.3389/fnbeh.2020.00009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7006220PMC
January 2020

Pregnancy-related acute kidney injury: mortality and survival of patients treated at a maternal intensive care unit.

J Nephrol 2020 Feb 18. Epub 2020 Feb 18.

Programa de Pós-Graduação Em Ciências Para a Saúde, Coordenação de Pós-Graduação E Extensão, Escola Superior de Ciências da Saúde (ESCS), SMHN Quadra 03, Conjunto A, Bloco 1, Edifício FEPECS Brasília, Brasília, DF, 70710-907, Brazil.

Introduction: Pregnancy-related acute kidney injury (AKI) can be defined as the abrupt decline in renal function during pregnancy or the postpartum period. It remains a relevant cause of fatal complications in obstetric patients. This study aimed to determine the incidence of pregnancy-related AKI in a maternal intensive care unit (ICU) as well as the associated risk factors for dialysis therapy and maternal mortality according to the KDIGO classification system. Read More

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http://dx.doi.org/10.1007/s40620-020-00711-6DOI Listing
February 2020

Effects of prenatal cold stress on maternal serum metabolomics in rats.

Life Sci 2020 Apr 13;246:117432. Epub 2020 Feb 13.

College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing 163319, PR China. Electronic address:

Our previous studies have shown that prenatal cold stress leads to placental inflammatory response and induces anxiety-like behavior reduced in offspring rats. However, the role and mechanisms by which prenatal cold stress affects offspring remain unclear. The aim of this study was to determine the metabolic profiles from the maternal serum and helpful in understanding the role and mechanisms by which prenatal cold stress affects the offspring. Read More

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http://dx.doi.org/10.1016/j.lfs.2020.117432DOI Listing

Embryo-maternal communication in dogs: Immune system related factors.

Theriogenology 2020 Jul 9;150:382-387. Epub 2020 Feb 9.

Near East University, Veterinary Faculty, Department for Obstetrics and Gynecology, Nicosia, Cyprus.

In the bitch, establishment of pregnancy is believed to be mainly initiated by the free-floating embryo in the uterus that is under progesterone influence. As in other species, the active participation of the embryo is no longer questioned. Secretory products are transported to the embryo-maternal interface and contribute to extra-cellular matrix (ECM) degradation, a change in the intrauterine immune milieu towards a reduction of immune cells and a change in lymphocyte subsets, cell differentiation, angiogenesis, and the balance between proliferation and apoptosis. Read More

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http://dx.doi.org/10.1016/j.theriogenology.2020.02.019DOI Listing

Multidisciplinary management of the pregnant patient in haemorrhagic shock secondary to an undiagnosed ruptured liver adenoma.

BMJ Case Rep 2020 Feb 13;13(2). Epub 2020 Feb 13.

Department of Surgery, George Washington University, Washington, DC, USA.

Management of a ruptured hepatocellular adenoma during pregnancy is a rare and potentially life-threatening entity. Few case reports have described management of the pregnant patient who presents in haemorrhagic shock secondary to a ruptured liver adenoma. A 30-year-old primigravid woman at 31 weeks pregnant presented with abdominal pain and fetal bradycardia. Read More

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http://dx.doi.org/10.1136/bcr-2019-231995DOI Listing
February 2020

The effects of weather shocks on early childhood development: Evidence from 25 years of tropical storms in Jamaica.

Econ Hum Biol 2020 May 1;37:100851. Epub 2020 Feb 1.

Centro de Estudios Regionales Cafeteros y Empresariales Km 11 Via al Magdalena, Manizales, Caldas, Colombia. Electronic address:

This study analyses the effects of exposure to tropical storms and hurricanes during pregnancy on children's anthropometric measures taken within the first five years of life. We merge destruction indexes calculated at the district level with 13 yearly rounds of household level surveys from Jamaica. The empirical strategy exploits variation arising from the storms' timing and intensity across different cohorts within the same district. Read More

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http://dx.doi.org/10.1016/j.ehb.2020.100851DOI Listing

[Predictive factors for poor prognosis of neonates with early-onset sepsis].

Authors:
Jie Chen Jia-Lin Yu

Zhongguo Dang Dai Er Ke Za Zhi 2020 Feb;22(2):146-151

Pediatric Research Institute, Children's Hospital of Chongqing Medical University/Ministry of Education Key Laboratory of Child Development and Disorders/National Clinical Research Center for Child Health and Disorders/China International Science and Technology Cooperation Base of Child Development and Critical Disorders/Chongqing Key Laboratory of Pediatrics, Chongqing 400014, China.

Objective: To study the predictive factors for poor prognosis of neonates with early-onset sepsis (EOS).

Methods: The clinical data of 371 neonates with EOS were collected. According to prognosis, they were divided into a good prognosis group with 264 neonates and a poor prognosis group with 107 neonates. Read More

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February 2020

New-onset lone maternal atrial fibrillation: A case report.

Medicine (Baltimore) 2020 Feb;99(7):e19156

Letterkenny University Hospital. Co. Donegal, Ireland.

Rationale: Atrial fibrillation (AF) is encountered rarely in pregnancy. Management of maternal AF is challenging as it poses a threat to both maternal and fetal well-being.

Patient Concerns: We report a case of a 35 weeks pregnant woman who presented in emergency with sudden-onset palpitations and mild shortness of breath with no personal/family history of cardiac diseases. Read More

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http://dx.doi.org/10.1097/MD.0000000000019156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7035010PMC
February 2020

Endocan - a potential diagnostic marker for early onset sepsis in neonates.

J Infect Dev Ctries 2019 04 30;13(4):311-317. Epub 2019 Apr 30.

Division of Pneumology, Department of Medical Specialties III, "Grigore T. Popa" University of Medicine and Pharmacy, Iași, Romania.

Introduction: Neonatal early onset sepsis assessment is based on the history of pregnancy and delivery and nonspecific clinical signs. None of the biomarkers currently in use for clinical practice has adequate prognostic value, so it is not possible to clearly distinguish neonates with culture-proven sepsis from those with only risk factors or clinical suspicion. Endocan is an endothelial mediator involved in the inflammatory response that is present in low concentrations in the serum of healthy subjects, and in much higher concentrations in patients with SIRS and septic shock. Read More

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http://dx.doi.org/10.3855/jidc.11202DOI Listing

Prenatal heat stress effects on gestation and postnatal behavior in kid goats.

PLoS One 2020 10;15(2):e0220221. Epub 2020 Feb 10.

Group of Research in Ruminants (G2R), Department of Animal and Food Science, Universitat Autònoma de Barcelona (UAB), Bellaterra, Barcelona, Spain.

Consequences of heat stress during pregnancy can affect the normal development of the offspring. In the present experiment, 30 Murciano-Granadina dairy goats (41.8 ± 5. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0220221PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7010273PMC

Mepivacaine-induced anaphylactic shock in a pregnant woman undergoing combined spinal and epidural anesthesia for cesarean delivery: a case report.

JA Clin Rep 2019 Dec 19;5(1):84. Epub 2019 Dec 19.

Department of Anesthesiology and Critical Care Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi, 329-0498, Japan.

Background: Anaphylactic shock during pregnancy is a rare but life-threatening event for both the mother and the newborn.

Case Presentation: A 42-year-old woman, who was pregnant with twins, was scheduled for cesarean delivery under combined spinal and epidural anesthesia. An epidural catheter was placed uneventfully. Read More

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http://dx.doi.org/10.1186/s40981-019-0302-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6967107PMC
December 2019

Soluble T cell immunoglobulin mucin domain 3 (sTim-3) in maternal sera: a potential contributor to immune regulation during pregnancy.

J Matern Fetal Neonatal Med 2020 Feb 4:1-4. Epub 2020 Feb 4.

Department of Obstetrics & Gynecology, Weill Cornell Medical College, New York, NY, USA.

The immune checkpoint inhibitor, membrane-bound T cell immunoglobulin mucin domain 3 (Tim-3), binds to galectin-9 (gal-9) and promotes immune tolerance during pregnancy. Soluble Tim-3 (sTim-3) competes with Tim-3 for binding to gal-9 and modulates its activity. Our objective was to evaluate the influence of sTim-3 on immune responses and outcome in pregnant women. Read More

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http://dx.doi.org/10.1080/14767058.2019.1706471DOI Listing
February 2020

Extracorporeal Membrane Oxygenation as Salvage Therapy in the Peripartum Period: A Case Series.

ASAIO J 2020 Jan 22. Epub 2020 Jan 22.

Liver Intensive Care & ECMO, King's College Hospital, London, United Kingdom.

Despite considerable advances in maternity care, maternal death rates remain unacceptably high. Even with optimal care, unexpected complications can result in catastrophic consequences. Hemorrhage, cardiovascular and coronary conditions, and cardiomyopathy make up the three most common causes of pregnancy-associated deaths, followed by sepsis and thromboembolic disease. Read More

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http://dx.doi.org/10.1097/MAT.0000000000001120DOI Listing
January 2020

Pregnancy outcomes in anti-NMDA receptor encephalitis: Case series.

Neurol Neuroimmunol Neuroinflamm 2020 May 16;7(3). Epub 2020 Jan 16.

From the Neuroimmunology Program (B.J., A.G.-S., J.P., E.M.-H., F.G., J.D.), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic, Universitat de Barcelona, Spain; Department of Neurology (A.K.), Martha-Maria Hospital, Halle, Germany; Department of Neurology (F.P.), Helios Hospital, Schleswig, Germany; Department of Neurology (T.I.), Kitasato University School of Medicine, Sagamihara, Japan; French Reference Center on Paraneoplastic Neurological Syndromes (B.J., J.H.), Hospices Civils de Lyon, SynatAc Team, Institut NeuroMyoGène, INSERM U1217/CNRS UMR 5310, Université de Lyon, Université Claude Bernard Lyon 1; France; Neuroimmunology Section (F.L.), Institute of Clinical Chemistry, University Hospital Schleswig-Holstein, Kiel/Lübeck, Germany; Department of Neurology (F.L.), Christian-Albrechts-University, Kiel, Germany; Institució Catalana de Recerca i Estudis Avançats (ICREA) (J.D.), Barcelona, Spain; and Department of Neurology (J.D.), University of Pennsylvania, PA.

Objective: To report the effects of anti-NMDA receptor (NMDAR) encephalitis in pregnant patients and their babies.

Methods: We studied a retrospective cohort of patients who developed anti-NMDAR encephalitis during pregnancy or became pregnant while recovering from the encephalitis. In addition, we reviewed the English literature between 2010 and 2019 related to this topic. Read More

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http://dx.doi.org/10.1212/NXI.0000000000000668DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7051205PMC

Chronic Sheehan's Syndrome - A Differential to be Considered in Clinical Practice in Women with a History of Postpartum Hemorrhage.

Cureus 2019 Dec 4;11(12):e6290. Epub 2019 Dec 4.

Internal Medicine, Saint Peters University Hospital, New Brunswick, USA.

Sheehan's syndrome is hypopituitarism due to pituitary gland necrosis resulting from hemorrhagic shock during pregnancy. It is a rare complication with varied manifestations and a considerable delay in diagnosis. We describe the case of a 36-year-old female with eight years of non-specific symptoms of generalized myalgias and intense fatigue managed symptomatically all these years. Read More

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http://dx.doi.org/10.7759/cureus.6290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942501PMC
December 2019

Correction to: Atypical presentation of hemorrhagic shock in pregnancy: a case highlighting the developing field of emergency medicine in Israel.

BMC Emerg Med 2020 01 15;20(1). Epub 2020 Jan 15.

Department of Emergency Medicine Ha-Refu'a St 7, Samson Assuta Ashdod Medical Center, 7747629, Ashdod, Israel.

The original article [1] contained a misspelling in first author, Baruch Berzon's name which has since been corrected. Read More

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http://dx.doi.org/10.1186/s12873-020-0301-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6961245PMC
January 2020

Emergency surgery for hemothorax due to a ruptured pulmonary arteriovenous malformation.

Gen Thorac Cardiovasc Surg 2020 Jan 13. Epub 2020 Jan 13.

Department of General Thoracic Surgery, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8670, Japan.

Pulmonary arteriovenous malformation (PAVM) is a potential cause of hemothorax. The risk of PAVM rupture is reported to be higher during pregnancy for several reasons, including increased body fluid and a change in hormonal conditions. A 34-year-old pregnant woman suddenly felt right chest pain and dyspnea in the 28th week of gestation. Read More

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http://dx.doi.org/10.1007/s11748-020-01291-9DOI Listing
January 2020

Pregnancy in Noncommunicating Rudimentary Horn of Unicornuate Uterus: A Case Report and Review of the Literature.

Case Rep Obstet Gynecol 2019 14;2019:1489751. Epub 2019 Dec 14.

Arsi University, College of Health Science, Department of Obstetrics & Gynecology, Asella, Ethiopia.

Pregnancy implanted in the rudimentary horn of unicornuate uterus is very rare with an incidence of 1 in 75,000 to 1 in 150,000 pregnancies. Both prerupture and postrupture diagnosis of ectopic pregnancy in the rudimentary horn of a unicornuate uterus is difficult. Here is a case of a 21-year-old gravida 5 para 3 abortion 1 mother presented with abdominal pain of 2 days duration following a falling accident. Read More

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http://dx.doi.org/10.1155/2019/1489751DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6939420PMC
December 2019

Anesthetic management of a patient with Sheehan's syndrome and twin pregnancy while undergoing a cesarean section.

Authors:
G Arora N Sahni

J Postgrad Med 2020 Jan-Mar;66(1):51-53

Department of Anesthesia and Intensive Care, PGIMER, Chandigarh, India.

Sheehan's syndrome (SS) is caused by infarction of the pituitary gland usually precipitated by hypotension due to massive uterine hemorrhage during the peripartum period. Once SS develops, it becomes a major comorbidity for the young females and predisposes them to further medical, obstetric, and anesthetic complications. Herein, we report the perioperative anesthetic management of a 28-year-old female, already diagnosed with SS precipitated by urosepsis and septicemic shock in a previous pregnancy, now presenting with twin pregnancy for elective cesarean section. Read More

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http://dx.doi.org/10.4103/jpgm.JPGM_473_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6970334PMC
January 2020

Group A Streptococcal Infection During Pregnancy and the Postpartum Period.

Nurs Womens Health 2020 Feb 6;24(1):13-23. Epub 2020 Jan 6.

Group A Streptococcus, the causative organism for "childbed fever," continues to pose a threat to women during pregnancy and the postpartum period, despite advances in hygiene and the development of antibiotic therapy. This resilient bacterium has resurfaced with intensified virulence, and, for reasons not entirely clear, causes severe disease in some women. Sepsis and toxic shock syndrome caused by Group A Streptococcus contribute to the alarming rates of maternal morbidity and mortality in the United States. Read More

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http://dx.doi.org/10.1016/j.nwh.2019.11.006DOI Listing
February 2020

Major obstetric haemorrhage in Metro East, Cape Town, South Africa: a population-based cohort study using the maternal near-miss approach.

BMC Pregnancy Childbirth 2020 Jan 6;20(1):14. Epub 2020 Jan 6.

Department of Obstetrics and Gynaecology, Stellenbosch University and Tygerberg Academic Hospital, Francie van Zijl Avenue, Cape Town, 7505, South Africa.

Background: Major obstetric haemorrhage is a leading cause of maternal mortality and accounts for one-third of maternal deaths in of Africa. This study aimed to assess the population-based incidence, causes, management and outcomes of major obstetric haemorrhage and risk factors associated with poor maternal outcome.

Methods: Women with major obstetric haemorrhage who met the WHO maternal near-miss criteria or died in the Metro East region, Cape Town, South Africa, were evaluated from November 2014-November 2015. Read More

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http://dx.doi.org/10.1186/s12884-019-2668-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6945549PMC
January 2020

HSP70: an alarmin that does not induce high rates of preterm birth but does cause adverse neonatal outcomes.

J Matern Fetal Neonatal Med 2020 Jan 6:1-9. Epub 2020 Jan 6.

Perinatology Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, MD, USA, and Detroit, MI, USA.

Preterm labor and birth are strongly associated with sterile intra-amniotic inflammation, a clinical condition that is proposed to be initiated by danger signals, or alarmins. The aim of this study was to investigate whether the intra-amniotic administration of the alarmin heat shock protein 70 (HSP70) induces preterm labor/birth and adverse neonatal outcomes. Pregnant mice received an intra-amniotic injection of 200 ng ( = 8), 400 ng ( = 6), 500 ng ( = 10), or 1 µg of HSP70 ( = 6). Read More

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http://dx.doi.org/10.1080/14767058.2019.1706470DOI Listing
January 2020

Refractory Ventricular Tachycardia From Coronary Vasospasm During Pregnancy.

Ochsner J 2019 ;19(4):401-404

Department of Cardiology, Ochsner Clinic Foundation, New Orleans, LA.

Coronary vasospasm leading to variant angina is uncommon, and the condition is rare in pregnant patients. Many physiologic changes occur during pregnancy, but how these changes affect the spasticity of coronary arteries in patients predisposed to vasospasm is unknown. Vasospasm causing unstable arrhythmia from multiple foci can be difficult to treat. Read More

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http://dx.doi.org/10.31486/toj.18.0046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928670PMC
January 2019

Postoperative cardiogenic shock secondary to Takotsubo's syndrome.

BMJ Case Rep 2019 Dec 31;12(12). Epub 2019 Dec 31.

Emergency Department, Chelsea and Westminster Hospital NHS Foundation Trust, London, UK.

Takotsubo's syndrome is a rare acute reversible heart failure, where the pathophysiology is not fully understood. It is being increasingly diagnosed in varied clinical contexts, which can result in atypical presentations in the context of surgical or anaesthetic stress. We discuss the case of a 22-year-old woman who developed cardiogenic shock and impaired left ventricular function after an elective gynaecological procedure. Read More

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http://dx.doi.org/10.1136/bcr-2019-233055DOI Listing
December 2019