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    Inorganic zinc supplementation modulates heat shock and immune response in heat stressed peripheral blood mononuclear cells of periparturient dairy cows.
    Theriogenology 2017 Jun 28;95:75-82. Epub 2017 Feb 28.
    Animal Physiology Division, ICAR-National Dairy Research Institute, Karnal, Haryana, India.
    Thermal stress in India is one of the major constraints affecting dairy cattle productivity. Every attempt should be made to ameliorate the heat and calving related stress in high producing dairy cows for higher economic returns. In the current study, inorganic zinc was tried to alleviate the adverse effects of thermal stress in periparturient cows. Read More

    Acute kidney injury during pregnancy and puerperium: a retrospective study in a single center.
    BMC Nephrol 2017 May 1;18(1):146. Epub 2017 May 1.
    Department of Nephrology, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, 363000, People's Republic of China.
    Background: Acute kidney injury (AKI) is rare in women during pregnancy and puerperium, however, it is related to increased morbidity and mortality rates.

    Objective: The aim of this study was to investigate the incidence, characteristics, and outcomes of AKI during pregnancy and puerperium in a Chinese population.

    Methods: In this study, pregnant women discharged from hospital between January 2008 and June 2015 were screened. Read More

    The heat shock protein 60 promotes progesterone synthesis in mitochondria of JEG-3 cells.
    Reprod Biol 2017 Apr 20. Epub 2017 Apr 20.
    Departamento de Bioquímica, Facultad de Medicina, Universidad Nacional Autónoma de México, Apartado Postal 70-159, Coyoacán, 04510 Mexico City, Mexico. Electronic address:
    Progesterone synthesis in human placenta is essential to maintain pregnancy. The limiting step in placental progesterone synthesis is cholesterol transport from the cytoplasm to the inner mitochondrial membrane. Multiple proteins located in mitochondrial contact sites seem to play a key role in this process. Read More

    Maternal and fetal outcomes of uterine rupture and factors associated with maternal death secondary to uterine rupture.
    BMC Pregnancy Childbirth 2017 Apr 12;17(1):117. Epub 2017 Apr 12.
    Institute of Public Health, Department of Health Informatics, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
    Background: Maternal mortality and morbidity are the priority agenda for sub-Saharan Africa including Ethiopia. Uterine rupture is the leading cause of maternal and fetal death in developing countries. Limited evidence is available on the magnitude of uterine rupture; maternal and fetal outcomes of uterine rupture and factors associated with maternal death secondary to uterine rupture in Ethiopia. Read More

    Sepsis in Obstetrics: Treatment, Prognosis, and Prevention.
    MCN Am J Matern Child Nurs 2017 Apr 10. Epub 2017 Apr 10.
    Sheryl E. Parfitt is a Clinical Educator, HonorHealth Scottsdale Shea Medical Center, Scottsdale, AZ. The author can be reached via e-mail at Mary L. Bogat is a Staff Nurse, HonorHealth Scottsdale Shea Medical Center, Scottsdale; Clinical Instructor, Scottsdale Community College, Scottsdale and Arizona State University, Tempe, AZ. Cheryl Roth is a Nurse Practitioner, HonorHealth Scottsdale Shea Medical Center, Scottsdale, AZ.
    Sepsis during pregnancy is one of the five leading causes of maternal mortality worldwide. Early recognition and prompt treatment of maternal sepsis is necessary to improve patient outcomes. Patient education on practices that reduce infections may be helpful in decreasing rates of sepsis. Read More

    Maternal Antibodies to Chlamydia trachomatis and Risk of Gastroschisis.
    Birth Defects Res 2017 May 24;109(8):543-549. Epub 2017 Feb 24.
    National Institute for Health and Welfare, Information Services Department, Helsinki, Finland.
    Background: Gastroschisis, a birth defect of the abdominal wall, is increasing in prevalence. The largest increase in prevalence has been observed among young mothers (<20 years). The prevalence of Chlamydia trachomatis (CT) infection is highest among young women and has also been increasing over time. Read More

    The Role of Hsp70 in the Regulation of Autophagy in Gametogenesis, Pregnancy, and Parturition.
    Adv Anat Embryol Cell Biol 2017 ;222:117-127
    Division of Immunology and Infectious Diseases, Department of Obstetrics and Gynecology, Weill Cornell Medicine, 1300 York Avenue, Box 35, New York, NY, 10065, USA.
    Induction of the 70 kDa heat shock protein (hsp70) and autophagy are two major mechanisms that promote cell homeostasis during the rapid cell growth and differentiation characteristic of reproduction. Hsp70 insures proper assembly, conformation, and intracellular transport of nascent proteins. Autophagy removes from the cytoplasm proteins, other macromolecules, and organelles that are no longer functional or needed and recycles their components for synthesis of new products under nutritionally limiting conditions. Read More

    The Potential Functions of Small Heat Shock Proteins in the Uterine Musculature during Pregnancy.
    Adv Anat Embryol Cell Biol 2017 ;222:95-116
    Department of Veterinary Biomedical Sciences, Western College of Veterinary Medicine, 52 Campus Dr., University of Saskatchewan, Saskatoon, SK, S7N 5B4, Canada.
    The small heat shock protein B (HSPB) family is comprised of eleven members with many being induced by physiological stressors. In addition to being molecular chaperones, it is clear these proteins also play important roles in cell death regulation, cytoskeletal rearrangements, and immune system activation. These processes are important for the uterine smooth muscle or myometrium during pregnancy as it changes from a quiescent tissue, during the majority of pregnancy, to a powerful and contractile tissue at labor. Read More

    Successful Continuation of Pregnancy After Treatment of Group A Streptococci Sepsis.
    Obstet Gynecol 2017 May;129(5):907-910
    Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, Michigan.
    Background: Invasive group A streptococci infections in pregnancy have historically led to severe maternal and neonatal morbidity and mortality. We are reporting a rare and novel case of successful treatment of third-trimester group A streptococci infection with early, aggressive intervention and maintenance of the pregnancy to term.

    Case: A 35 year old woman initially presented with fever, flu-like symptoms, and preterm contractions at 34 weeks of gestation. Read More

    Immunohistochemical evaluation of the influence of L-arginine on biomarkers of environmental (cellular) stress in the kidneys of pregnant female rats.
    Ann Agric Environ Med 2017 Mar;24(1):121-128
    Department of Maritime and Hyperbaric Medicine Military Institute of Medicine, Gdynia, Poland.
    Introduction: Kidney damage during pregnancy constitutes a diagnostic and therapeutic challenge. However, it is not entirely known whether a kidney condition recognised before the pregnancy releases an organism's response to pregnancy, or whether pregnancy itself worsens kidney function.

    Objective: The aim of the study was immunohistochemical evaluation of cells of kidneys of pregnant rats under the influence of nitric oxide (NO), with measurement of the immunoexpression of cellular stress markers (p-53, HSP 70). Read More

    Pregnancy-related acute kidney injury: An analysis of 165 cases.
    Indian J Nephrol 2017 Mar-Apr;27(2):113-117
    Department of Nephrology, M. S. Ramaiah Medical College, Bengaluru, Karnataka, India.
    Pregnancy-related acute kidney injury (PRAKI) contributes to 3-7% of overall acute kidney injury (AKI) cases in Indian subcontinent. The aim of this study was to determine the outcomes of PRAKI and risk factors associated with renal injury and maternal mortality. One hundred and sixty-five patients with PRAKI, seen at M. Read More

    Term Abdominal Pregnancy Revealed by Amnioperitoneum in Rural Area.
    Case Rep Obstet Gynecol 2017 26;2017:4096783. Epub 2017 Feb 26.
    Mbouda District Hospital, Mbouda, Cameroon; Geneva University Hospitals, Geneva, Switzerland.
    Abdominal pregnancy (AP) accounts for 1% of ectopic implantations. In sub-Saharan Africa, the high prevalence of sexually transmitted infections explains the increasing frequency of this pathology. In Cameroon it rose from 1/10000 deliveries (1995) to 3. Read More

    The emotional process from diagnosis to birth following a prenatal diagnosis of fetal anomaly: A qualitative study of messages in online discussion boards.
    Midwifery 2017 May 2;48:53-59. Epub 2017 Mar 2.
    Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden; Department of Health Care Sciences, Ersta Sköndal Bräcke University College, Stockholm, Sweden.
    Objective: to explore written statements found in online discussion boards where parents currently expecting, or with previous experience of expecting, a child with a prenatally diagnosed congenital anomaly communicate about their emotional process from diagnosis to birth.

    Design: cross-sectional qualitative study of messages in public online discussion boards.

    Setting: Swedish public discussion boards about reproductive subjects. Read More

    Treatment selection for urolithiasis: percutaneous nephrolithomy, ureteroscopy, shock wave lithotripsy, and active monitoring.
    World J Urol 2017 Mar 16. Epub 2017 Mar 16.
    Department of Urology, Muljibhai Patel Urological Hospital, Nadiad, India.
    Urolithiasis is a significant worldwide source of morbidity, constituting a common urological disease that affects between 10 and 15% of the world population. Recent technological and surgical advances have replaced the need for open surgery with less invasive procedures. The factors which determine the indications for percutaneous nephrolithotomy include stone factors (stone size, stone composition, and stone location), patient factors (habitus and renal anomalies), and failure of other treatment modalities (ESWL and flexible ureteroscopy). Read More

    Pregnancy and the Risk of Spontaneous Coronary Artery Dissection: An Analysis of 120 Contemporary Cases.
    Circ Cardiovasc Interv 2017 Mar;10(3)
    From the Division of Cardiovascular Medicine, Department of Medicine and Department of Obstetrics and Gynecology, University of Southern California, Los Angeles.
    Background: Because of the rarity of this condition, information on pregnancy-associated spontaneous coronary artery dissection is limited. We reviewed a large number of contemporary pregnancy-associated spontaneous coronary artery dissection cases in an attempt to define the clinical characteristics and provide management recommendations.

    Methods And Results: A literature search for cases of pregnancy-associated spontaneous coronary artery dissection reported between 2000 and 2015 included 120 cases; 75% presented with ST-segment-elevation myocardial infarction, and 80% had anterior myocardial infarction. Read More

    Sepsis in Obstetrics: Clinical Features and Early Warning Tools.
    MCN Am J Matern Child Nurs 2017 Mar 15. Epub 2017 Mar 15.
    Sheryl E. Parfitt is a Clinical Educator, HonorHealth Scottsdale Shea Medical Center, Scottsdale, AZ. The author can be reached via e-mail at Mary L. Bogat is a Staff Nurse, HonorHealth Scottsdale Shea Medical Center, Scottsdale; Clinical Instructor, Scottsdale Community College, Scottsdale and Arizona State University, Tempe, AZ. Sandra L. Hering is Informatics Support Specialist, HonorHealth Scottsdale Shea Medical Center, Scottsdale, AZ. Charlotte Ottley is Clinical Director, HonorHealth Scottsdale Osborn Medical Center, Scottsdale, AZ. Cheryl Roth is a Nurse Practitioner, HonorHealth Scottsdale Shea Medical Center, Scottsdale, AZ.
    Morbidity and mortality associated with sepsis has gained widespread attention on a local, state, and national level, yet, it remains a complicated disorder that can be difficult to identify in a timely manner. Sepsis in obstetric patients further complicates the diagnosis as alterations in physiology related to pregnancy can mask sepsis indicators normally seen in the general population. If early signs of sepsis go unrecognized, septic shock can develop, leading to organ dysfunction and potential death. Read More

    [Ovarian pregnancy: about 3 cases and review of the literature].
    Pan Afr Med J 2016 2;25:128. Epub 2016 Nov 2.
    UPFR Anatomie et Cytologie pathologiques du CHU/JRA, Antananarivo, Madagascar.
    Ovarian pregnancy is a rare event among women with ectopic pregnancy in whom the ovary is the site of implantation. Its diagnosis requires a well codified approach. The peculiarities of the determining factors, of the histopathological and evolutionary features typical of ovarian pregnancies led us to focus on this form of ectopic pregnancy. Read More

    [Clinical comparative analysis of surgical resection of the pregnancy by hysterotomy and hysterectomy for cesarean scar pregnancy].
    Zhonghua Fu Chan Ke Za Zhi 2017 Feb;52(2):98-102
    Department of Gynecology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China.
    Objective: To assess the indication and safety of surgical resection of the pregnancy by hysterotomy (SRPH) and hysterectomy for cesarean scar pregnancy (CSP). Methods: A retrospective study of women with CSP was conducted at the Women's Hospital, School of Medicine, Zhejiang University, from Jan. 2003 to Mar. Read More

    Suspected atypical haemolytic uraemic syndrome in two post-partum patients with foetal-death in utero responding to eculizumab.
    Nephrology (Carlton) 2017 Feb;22 Suppl 1:18-22
    Department of Nephrology, Austin Hospital, Victoria, Australia.
    Background: Atypical haemolytic uraemic syndrome (aHUS) is a rare condition with the triad of microangiopathic haemolytic anaemia, thrombocytopenia and acute kidney injury. Other conditions that present in a similar manner peri-partum include thrombotic thrombocytopaenic purpura, and pregnancy associated conditions including HELLP syndrome (haemolysis, elevated liver enzymes and low platelets), severe pre-eclampsia and less commonly acute fatty liver of pregnancy.

    Case Reports: We describe two cases of suspected aHUS, who presented post-partum with foetal death-in-utero at 33 and 37 weeks respectively. Read More

    Maternal Type 1 diabetes activates stress response in early placenta.
    Placenta 2017 Feb 16;50:110-116. Epub 2017 Jan 16.
    Department of Obstetrics and Gynecology, Medical University of Graz, Austria. Electronic address:
    Introduction: Human pregnancy and in particular the first trimester, is a period highly susceptible towards adverse insults such as oxidative stress, which may lead to inadequate embryonic and feto-placental development. Diabetes mellitus is associated with increased oxidative stress caused by hyperglycemia, reactive oxygen species (ROS) production and inflammatory signals. In pregnancy, diabetes elevates the risk for early pregnancy loss, preeclampsia and fetal growth restriction, pathologies that origin from early placental maldevelopment. Read More

    A rare case of dengue encephalopathy complicating a term pregnancy.
    BMC Res Notes 2017 Feb 2;10(1):79. Epub 2017 Feb 2.
    Sri Jayewardenepura General Hospital, Sri Jayewardenepura, Kotte, Sri Lanka.
    Background: Dengue fever has an expanded clinical spectrum ranging from an asymptomatic infection to life threatening dengue hemorrhagic fever and refractory shock. Dengue infection in pregnancy can be a diagnostic dilemma, particularly considering the physiological changes in pregnancy and the obstetric complications encountered in clinical practice. Hence the knowledge of its diagnosis and management in its atypical presentations is of paramount importance. Read More

    [Dying at Life's Beginning].
    Gesundheitswesen 2017 Jan 27. Epub 2017 Jan 27.
    Zürcher Hochschule für Angewandte Wissenschaften, Gesundheit, Winterthur, Switzerland.
    Aim: When parents-to-be are faced with a terminal prenatal diagnosis, they are confronted with the decision either to continue the pregnancy or to terminate it at an advanced stage. This difficult decision is intimately affected by the experience of the inevitability of loss, and ethical dilemmas posed in this usually completely unexpected situation. Studies indicate that perinatal child loss due to lethal foetal anomalies is a major life event and a source of serious psychological issues, which can last for many years after the experience. Read More

    SIRT1 inhibits releases of HMGB1 and HSP70 from human umbilical vein endothelial cells caused by IL-6 and the serum from a preeclampsia patient and protects the cells from death.
    Biomed Pharmacother 2017 Apr 22;88:449-458. Epub 2017 Jan 22.
    Department of Obstetrics and Gynecology, The Affiliated Maternity and Child Health Hospital of Nanjing Medical University, Wuxi, Jiangsu Province 214002, China.
    Preeclampsia (PE), a pregnancy-specific disorder, is associated with inappropriate maternal inflammatory response, oxidative stress, and vascular endothelial cell dysfunction and damage. Releases of high mobility group box-1 (HMGB1) and heat-shock protein 70 (HSP70) into serum are considered to participate in the pathogenesis of PE. The deacetylase, sirtuin 1 (SIRT1), has protective effects against inflammation, apoptosis, and oxidative stress in various pathological conditions. Read More

    [Effect of heat exposure in the second trimester of pregnancy on intrauterine growth of fatal rat and the expression of HSP70, Bax and Bcl-2 of placenta].
    Nan Fang Yi Ke Da Xue Xue Bao 2017 Jan;37(1):89-92
    Medical College of Nanchang University, Nanchang 330006, China.E-mail:
    Objective: To investigate the effect of heat exposure during the second week of pregnancy on placental development and intrauterine growth of fetal rats.

    Methods: 24 pregnant rats were either exposed or not to a temperature of 35∓1 degrees celsius; during the second week of pregnancy. The body weight gain of the pregnant rats was measured regularly, and in late pregnancy, the pregnant rats were dissected and the number, weight, length, tail length, appearance of the offspring rats, number of live and still births, and the placental weight were recorded. Read More

    Factors associated with maternal death in an intensive care unit.
    Rev Bras Ter Intensiva 2016 Oct-Dec;28(4):397-404
    Programa de Pós-Graduação em Saúde Coletiva, Universidade de Fortaleza - Fortaleza (CE), Brasil.
    Objective:: To identify factors associated with maternal death in patients admitted to an intensive care unit.

    Methods:: A cross-sectional study was conducted in a maternal intensive care unit. All medical records of patients admitted from January 2012 to December 2014 were reviewed. Read More

    Gastric Rupture in Pregnancy: Case Series from a Tertiary Institution in Rwanda and Review of the Literature.
    AJP Rep 2016 Oct;6(4):e436-e441
    Department of Obstetrics and Gynecology, University of Rwanda, Rwanda; Department of Obstetrics and Gynecology, Duke University, Durham, North Carolina; Department of Obstetrics and Gynecology, Yale University, New Heaven, Connecticut.
    Background Gastric rupture is a rare, life-threatening condition during pregnancy. Case study We present three cases of gastric perforation during pregnancy and the puerperium. The first patient presented with gastric perforation 4 days following an uncomplicated cesarean delivery for obstetric indications. Read More

    Spontaneous rupture of renal angiomyolipoma during pregnancy.
    BMJ Case Rep 2017 Jan 6;2017. Epub 2017 Jan 6.
    Department of Obstetrics and Gynecology, University of Yamanashi, Chuo, Yamanashi, Japan.
    A renal angiomyolipoma (AML) is a rare benign tumour of kidney origin. Pregnancy is known to be associated with an increased risk of tumour rupture causing hypovolaemic shock, which is usually managed surgically or through an embolisation procedure. However, having surgery during pregnancy predisposes the mother to a preterm delivery, and the unknown influences of radiation exposure to the fetus make the management of such cases very challenging. Read More

    Primary Abdominal Pregnancy: A Case Report.
    J Clin Diagn Res 2016 Nov 1;10(11):QD04-QD06. Epub 2016 Nov 1.
    Senior Resident, Department of Obstetrics and Gynaecology, GMCH , Sector 32, Chandigarh, India .
    Abdominal pregnancy is a potentially life threatening form of ectopic gestation with an incidence of 1% of all the ectopic pregnancies. Rarely, it may reach at advanced gestation and a viable fetal outcome is indeed a rare event. Most of them are terminated earlier due to poor fetal prognosis and higher chances of maternal mortality secondary to haemorrhagic shock following spontanous placental separation. Read More

    An Unusual Cause of Postabortal Fever Requiring Prompt Surgical Intervention: A Pyomyoma and its Imaging Features.
    Oman Med J 2017 Jan;32(1):73-76
    Radiodiagnosis, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
    Pyomyoma is an unusual complication of leiomyoma, occurring most commonly in the postpartum, postabortal, and post-menopausal periods. It develops due to infection in necrotic foci within leiomyoma, which is more common during pregnancy due to rapid growth, and in postmenopausal women due to vascular insufficiency. Other contributing factors are curettage, gynecological surgery, cervical stenosis, immunodeficiency, and recently, uterine artery embolization. Read More

    Cholesterol-loaded cyclodextrin improves ram sperm cryoresistance in skim milk-extender.
    Anim Reprod Sci 2017 Feb 1;177:1-11. Epub 2016 Dec 1.
    Centre de Recherche en Reproduction, Développement et Santé Intergénérationnelle, Département des Sciences Animales, Université Laval, Québec, QC G1V 0A6, Canada. Electronic address:
    Cholesterol-loaded cyclodextrin (CLC) is known to improve ram sperm cryosurvival. This study expands on previous research to: (1) determine the mechanism by which CLC improves ram sperm cryosurvival and (2) compare the efficiency of a novel, skim milk-based extender containing CLC to a traditional egg yolk-based extender. Hypothesis #1 was that CLC enhances membrane cholesterol content to increase the resistance of ram sperm to cold and osmotic stress, thereby improving cryosurvival. Read More

    A Case of Refractory Systemic Capillary Leak Syndrome (Clarkson's Disease) during Pregnancy.
    Acta Med Okayama 2016 Dec;70(6):497-501
    Department of Anesthesiology and Resuscitology, Okayama University Hospital, Okayama 700-8558,
    A 32-year-old woman, pregnant with twins, presented with a chief complaint of general fatigue. Her general condition had rapidly deteriorated since her last visit to the primary obstetrician; the patient was then referred to our hospital because of suspected fetal death. She underwent emergency cesarean section because fetal death had indeed occurred, and she was then admitted to the intensive care unit (ICU). Read More

    Management of severe dengue hemorrhagic fever and bleeding complications in a primigravida patient: a case report.
    J Med Case Rep 2016 Dec 20;10(1):357. Epub 2016 Dec 20.
    Department of Anesthesiology and Critical Care Medicine, 3rd floor, Siloam Hospitals Lippo Village, Jalan Siloam No. 6, Karawaci, 15811, Tangerang, Banten, Indonesia.
    Background: The incidence of dengue hemorrhagic fever is increasing among the adult population living in endemic areas. The disease carries a 0.73% fatality rate for the general population, but what happens when the disease strikes a special subpopulation group, the obstetrics? Perhaps the important question specific to this special subpopulation revolves around the right time and mode of delivery under severe coagulopathy and plasma leakage in conditions of imminent delivery. Read More

    Circulating heat shock protein mRNA profile in gestational hypertension, pre-eclampsia & foetal growth restriction.
    Indian J Med Res 2016 Aug;144(2):229-237
    The Third Faculty of Medicine, Institute for the Care of the Mother & Child, Charles University, Podolske Nabrezi 157/36, 147 00 Prague, Czech Republic.
    Background & Objectives: Heat shock proteins (Hsp) are ubiquitously distributed phylogenetically conserved molecules that regulate cellular homeostasis and maintain the integrity and function of cellular proteins. Increased levels of Hsp in maternal circulation have been shown to be associated with increased risk of pregnancy related complications. The objective of this study was to explore extracellular Hsp mRNA levels in maternal circulation and quantified Hsp27, Hsp60, Hsp70, Hsp90 and Hsp70 binding protein 1 (HspBP1) mRNAs in maternal plasma samples using real-time reverse-transcriptase polymerase chain reaction. Read More

    Hyperthyroidism secondary to hysterosalpingography: an extremely rare complication: A case report.
    Medicine (Baltimore) 2016 Dec;95(49):e5588
    aDepartment of Cardiac Surgery, Peking Union Medical College Hospital, Beijing, China bDepartment of Plastic Surgery, Plastic Surgery Hospital (Institute), Chinese Academy of Medical Science & Peking Union Medical College (CAMS & PUMC), Beijing, China.
    Rationale: Hysterosalpingography (HSG), a standard procedure for the evaluation of women with infertility and repetitive pregnancy loss, is associated with complications such as uterine perforation, infection, allergic reactions, syncope, hemorrhage and shock, and pulmonary or retinal embolus. However, hyperthyroidism has not been reported as one of its complications.

    Patient Concerns And Diagnoses: We report the case of a 33-year-old euthyroid woman who presented to our hospital with palpitation, hand tremor, fatigue, and excessive sweating after HSG. Read More

    Global protein expression analysis of molecular markers of DS-1-47, a component of implantation-promoting traditional chinese medicine.
    J Huazhong Univ Sci Technolog Med Sci 2016 Dec 7;36(6):910-915. Epub 2016 Dec 7.
    Department of Traditional Chinese Medicine, School of Pharmacy, Tongji Medical School, Huazhong University of Science and Technology, Wuhan, 430030, China.
    This study investigated the molecular markers of DS-1-47, a component of an implantation- promoting traditional Chinese medicine consisting of Astragalus mongholicus, Atractylodes macrocephala, Scutellaria baicalensis and Dipsacales, in an attempt to clarify the molecular mechanism and action targets of DS-1-47. Controlled ovarian stimulation (COS) method was used to establish the implantation dysfunction models of mice. Animals were divided into normal pregnant group, COS model group and DS-1-47 group. Read More

    Pancreatic and Hepatic Metastasis of an Undiagnosed Choriocarcinoma: An Exceptional Cause of Haemoperitoneum in Young Women - Report of a Rare Case.
    Case Rep Oncol 2016 Sep-Dec;9(3):633-638. Epub 2016 Oct 17.
    Department of Medicine, Ibri Regional Hospital, Ibri, Sultanate of Oman.
    Haemoperitoneum in women of reproductive age usually suggests either ruptured ectopic pregnancy or ruptured ovarian cysts. Metastatic choriocarcinoma is considered the least common cause of haemoperitoneum in women of childbearing age. We report a rare case of pancreatic and hepatic metastasis of choriocarcinoma in a young, 30-year-old female who had delivered 10 months prior at term gestation with no previous history of gestational trophoblastic disease or molar pregnancy. Read More

    What is the impact of extracorporeal shock wave lithotripsy on semen parameters? A systematic review and meta-analysis.
    Urologia 2017 Feb 2;84(1):28-34. Epub 2016 Dec 2.
    Urology and Nephrology Research Center, Shahid Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran - Iran.
    Background: Extracorporeal shock wave lithotripsy (ESWL) is an important tool for the management of urolithiasis. The effects of shockwaves on tissues are established. The aim of this meta-analysis is to evaluate the microscopic semen characteristics of young men before and after ESWL treatment for lower ureteral calculi. Read More

    Prenatal diagnosis of spontaneous twin anemia-polycythemia sequence and postnatal examination of placental vascular anastomoses.
    Obstet Gynecol Sci 2016 Nov 15;59(6):539-543. Epub 2016 Nov 15.
    Department of Obstetrics and Gynecology, Catholic University of Daegu School of Medicine, Daegu, Korea.
    Twin anemia-polycythemia sequence (TAPS) is characterized by a wide discrepancy of hemoglobin between two monochorionic fetuses without sign of twin oligo-polyhydramnios sequence. A primiparous woman with monochorionic diamniotic twin transferred for preterm labor. Ultrasonographic evaluation at 32+3 weeks of gestation revealed increased middle cerebral artery-peak systolic velocity (77. Read More

    Case Study: Obstetrical Trauma With Maternal Death and Fetal Survival.
    Crit Care Nurs Q 2017 Jan/Mar;40(1):36-40
    Shock Trauma Center, Allegheny General Hospital, Pittsburgh, Pennsylvania.
    Trauma during pregnancy is the leading cause of non-obstetric-related maternal and fetal death. This article summarizes obstetric physiology and outlines the assessment and treatment of traumatic injuries of the pregnant patient. A case is presented in which a pregnant woman with blunt abdominal trauma was managed efficiently in a trauma center within a hospital that does not have in-house obstetric services. Read More

    Cesarean section in the setting of severe pulmonary hypertension requiring extracorporeal life support.
    Gen Thorac Cardiovasc Surg 2016 Nov 25. Epub 2016 Nov 25.
    Division of Cardiac Surgery, The Johns Hopkins Hospital, Zayed 7107, 1800 Orleans St, Baltimore, MD, 21287, USA.
    We describe the use of veno-arterial extracorporeal membrane oxygenation (ECMO) in a 35-year-old female with severe fixed pulmonary hypertension who went into cardiogenic shock during a Cesarean section. Pregnancy in the presence of severe pulmonary hypertension is typically contraindicated due to high maternal mortality rates. This patient visited our hospital at 37 weeks of gestation after experiencing dyspnea and chest pain. Read More

    [Septic shock in pregnancy on the basis of an acute pyelonephritis].
    Ceska Gynekol 2016 ;81(4):286-288
    Objective: According to the World Health Organisation, sepsis is one of the four main causes of pregnancy-related mortality worldwide, together with hemorrhage, hypertensive disease and abortion. The main goal of this paper is an analysis of one case of septic shock in pregnancy.

    Design: A case report. Read More

    Veno-venous ECMO as a safe bridge to recovery in a patient with severe peripartum cardiomyopathy - learning from errors.
    Perfusion 2017 May 23;32(4):328-332. Epub 2016 Nov 23.
    4 Department of Intensive Care and Emergency Medicine, HELIOS Frankenwaldklinik Kronach, 96317 Kronach, Germany.
    Peripartum cardiomyopathy (PPCM) is a rare disorder of unknown etiology and pathogenesis. The most important tool for diagnostic confirmation is transthoracic echocardiography. The recommended management of PPCM in pregnancy is summarized by the European Society of Cardiology Heart Failure Guidelines. Read More

    Management of uterine rupture: a case report and review of the literature.
    BMC Res Notes 2016 Nov 21;9(1):492. Epub 2016 Nov 21.
    Department of Obstetrics and Gynecology, Douala General Hospital, Douala, Cameroon.
    Background: Maternal morbidity and mortality has been a major World Health Organization concern over the years, especially in sub-Saharan Africa. This paper reports uterine rupture with severe hypovolemic shock managed at the Douala General Hospital, Cameroon. Early clinical diagnosis is paramount to maternal survival. Read More

    The Case for Improved Interprofessional Care: Fatal Analgesic Overdose Secondary to Acute Dental Pain during Pregnancy.
    Case Rep Dent 2016 26;2016:7467262. Epub 2016 Oct 26.
    Department of Oral and Maxillofacial Surgery/Hospital Dentistry, School of Dentistry, University of Michigan, Ann Arbor, MI, USA.
    Prenatal oral health extends beyond the oral cavity, impacting the general well-being of the pregnant patient and her fetus. This case report follows a 19-year-old pregnant female presenting with acute liver failure secondary to acetaminophen overdose for management of dental pain following extensive dental procedures. Through the course of her illness, the patient suffered adverse outcomes including fetal demise, acute kidney injury, spontaneous bacterial peritonitis, and septic shock before eventual death from multiple organ failure. Read More

    Cardiogenic shock in pregnancy: Analysis from the National Inpatient Sample.
    Hypertens Pregnancy 2016 Nov 11:1-7. Epub 2016 Nov 11.
    a Department of Anesthesia and Critical Care , University of Chicago , Chicago , Illinois , USA.
    Objective: Cardiogenic shock (CS) may occur during pregnancy and dramatically worsen peripartum outcomes.

    Methods: We analyzed the National Inpatient Sample from 2002 to 2013 to describe the incidence of, risk factors for and outcomes of CS during pregnancy.

    Results: Of the 53,794,192 hospitalizations analyzed, 2044 were complicated by CS. Read More

    The sheep conceptus modulates proteome profiles in caruncular endometrium during early pregnancy.
    Anim Reprod Sci 2016 Dec 2;175:48-56. Epub 2016 Nov 2.
    UMR BDR, INRA, ENVA, Université Paris Saclay, 78350 Jouy en Josas, France. Electronic address:
    The stage-specific expression of functional proteins within the endometrium, and their regulation by conceptus-derived signals, are crucial for conceptus development and successful establishment of pregnancy. Accurate knowledge of endometrium-conceptus interactions is key for the development of effective strategies to improve conceptus implantation rates both following natural conception and/or assisted reproductive technologies. The unilateral pregnant ewe provides a powerful experimental model for the study of endometrial function in the presence or absence of conceptuses during the peri-implantation period. Read More

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