5,045 results match your criteria Shock and Pregnancy


LPS-induced Hypotension in Pregnancy: The Effect of Progesterone Supplementation.

Shock 2019 Apr 14. Epub 2019 Apr 14.

Imperial College Parturition Research Group, Chelsea and Westminster Hospital, 369 Fulham Road, London, SW10 9NH, UK.

Our previous work has shown that pregnancy exacerbates the hypotensive response to both infection and LPS. The high levels of progesterone (P4) associated with pregnancy have been suggested to be responsible for the pregnancy-induced changes in the cardiovascular response to infection. Here, we test the hypothesis that P4 supplementation exacerbates the hypotensive response of the maternal cardiovascular to LPS. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001343DOI Listing
April 2019
1 Read

Four years' experience of a ROTEM -guided algorithm for treatment of coagulopathy in obstetric haemorrhage.

Anaesthesia 2019 Apr 5. Epub 2019 Apr 5.

Chelsea and Westminster Hospital NHS Foundation Trust, London, UK.

We report four years of observational data from a large UK hospital and tertiary referral unit, following the introduction of a rotational thromboelastometry-guided algorithm for treatment of coagulopathy in major obstetric haemorrhage. Fibrinogen concentrate was used to treat acquired hypofibrinogenaemia as defined by a FibTEM A5 value of < 7 mm, or 7-12 mm with ongoing or high risk of haemorrhage. Of 32,647 deliveries over 4 years, 893 (2. Read More

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http://dx.doi.org/10.1111/anae.14628DOI Listing
April 2019
1 Read

Successful laparoscopic management of diaphragmatic pregnancy:a rare case report and brief review of literature.

BMC Pregnancy Childbirth 2019 Mar 28;19(1):99. Epub 2019 Mar 28.

Departments of Gynecology, Zhejiang Provincial People's Hospital, People's Hospital Of Hangzhou Medical College, No. 158 Shangtang Rd, Hangzhou, 310014, People's Republic of China.

Background: Abdominal ectopic pregnancies are rare category of ectopic pregnancies.We describe a ectopic pregnancy implanted on the surface of diaphragm and highlight the difficult clinical course of an abdominal ectopic pregnancy managed with strategic procedural intervention.

Case Presentation: A 33-year-old Chinese woman with abdominal pain was diagnosed with ectopic pregnancy implanted in the liver according to CT and advised to transfer the patient to tertiary referral center. Read More

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http://dx.doi.org/10.1186/s12884-019-2248-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438013PMC
March 2019
1 Read

Handling has an anxiolytic effect that is not affected by the inhibition of the protein kinase C pathway in adult prenatal undernourished male rat offspring.

Congenit Anom (Kyoto) 2019 Mar 18. Epub 2019 Mar 18.

Division of Anatomy and Cell Biology, Department of Anatomy, Shiga University of Medical Science, Otsu, Japan.

Environmental enrichment (EE) after birth has been reported as an intervention improving the anxiety-like behavior and cognitive deficit due to maternal restraint, foot-shock, or social stress during pregnancy. However, it remains unclear whether EE after birth could benefit the early prenatal undernourished offspring. In this study, we examined the effect of daily handling as a simple EE intervention on the aberrant behavior of prenatally undernourished rats. Read More

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http://dx.doi.org/10.1111/cga.12332DOI Listing
March 2019
2 Reads

Embolization of Ruptured Renal Angiomyolipoma in Puerpera.

Rev Bras Ginecol Obstet 2019 Mar 13;41(3):199-202. Epub 2019 Mar 13.

School of Medicine, Centro Universitário do Estado do Pará, Belém, PA, Brazil.

Angiomyolipomas (AMLs) are rare benign tumors derived from mesenchymal tissue and composed of varying degrees of adipose tissue, muscle and blood vessels. Renal AMLs (RAMLs) are the result of a sporadic event, and, in most of cases, the diagnosis is usually incidental, but hemorrhage and shock may be present. During pregnancy, the size of AMLs may increase and they may rupture, probably due to the high expression of hormone receptors, and the increase in maternal circulation and abdominal pressure. Read More

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http://dx.doi.org/10.1055/s-0039-1683948DOI Listing
March 2019
2 Reads

Venoarterial Extracorporeal Membrane Oxygenation as Supportive Therapy After Cardiac Arrest After Amniotic Fluid Embolism: A Case Report.

A A Pract 2019 Mar 6. Epub 2019 Mar 6.

From the Departments of Anesthesiology and Surgical Intensive Care.

Amniotic fluid embolism is a rare but dreaded complication of pregnancy, with an incidence between 2 and 7/100,000 deliveries. We report an amniotic fluid embolism after urgent cesarean delivery diagnosed on a cardiac arrest, complicated by cardiogenic shock and acute respiratory distress syndrome. This report describes the indication, efficacy, and success of venoarterial extracorporeal membrane oxygenation in the early management of cardiac arrest, cardiac failure driven by amniotic fluid embolism, and acute respiratory distress syndrome. Read More

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http://dx.doi.org/10.1213/XAA.0000000000000995DOI Listing
March 2019
3 Reads

Retrospective Analysis of Obstetric Intensive Care Unit Admissions Reveals Differences in Etiology for Admission Based on Mode of Conception.

Anesth Analg 2019 Feb 27. Epub 2019 Feb 27.

From the Department of Anesthesiology, Perioperative and Pain Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.

Background: The use of in vitro fertilization is increasing. The incidence of adverse outcomes is greater for women who undergo in vitro fertilization, potentially leading to intensive care unit admission. This study aimed to assess the etiology and course of intensive care unit admission in women who underwent in vitro fertilization compared to those who did not, with specific focus on intensive care unit admission due to postpartum hemorrhage. Read More

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http://dx.doi.org/10.1213/ANE.0000000000004056DOI Listing
February 2019
3 Reads

Anti-N-methyl-d-aspartate receptor encephalitis during pregnancy: A case report.

J Obstet Gynaecol Res 2019 Apr 20;45(4):935-937. Epub 2019 Feb 20.

Department of Neurology, Izmir Dokuz Eylul University Faculty of Medicine, Izmir, Turkey.

Following a generalized tonic-clonic seizure, a previously healthy 27-year-old pregnant woman (18-week pregnancy) was admitted to our emergency department. She experienced lethargy, forgetfulness and persecutory hallucinations the day before hospitalization. Cerebrospinal fluid examination revealed moderate pleocytosis, and abdominal ultrasonography did not detect neoplasia. Read More

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http://dx.doi.org/10.1111/jog.13892DOI Listing
April 2019
3 Reads

SMFM Consult Series #47: Sepsis during pregnancy and the puerperium.

Am J Obstet Gynecol 2019 Apr 23;220(4):B2-B10. Epub 2019 Jan 23.

Society for Maternal-Fetal Medicine, 409 12 St. SW, Washington, DC 20024, USA.

Maternal sepsis is a significant cause of maternal morbidity and mortality and is a preventable cause of maternal death. The purpose of this guideline is to summarize what is known about sepsis and to provide guidance for the management of sepsis in pregnancy and the postpartum period. The following are SMFM recommendations: (1) we recommend that sepsis and septic shock be considered medical emergencies and that treatment and resuscitation begin immediately (GRADE 1B); (2) we recommend that providers consider the diagnosis of sepsis in pregnant patients with otherwise unexplained end-organ damage in the presence of an infectious process, regardless of the presence of fever (GRADE 1B); (3) we recommend that empiric broad-spectrum antibiotics be administered as soon as possible, ideally within 1 hour, in any pregnant woman in whom sepsis is suspected (GRADE 1B); (4) we recommend obtaining cultures (blood, urine, respiratory, and others as indicated) and serum lactate levels in pregnant or postpartum women in whom sepsis is suspected or identified, and early source control should be completed as soon as possible (GRADE 1C); (5) we recommend early administration of 1-2 L of crystalloid solutions in sepsis complicated by hypotension or suspected organ hypoperfusion (GRADE 1C); (6) we recommend the use of norepinephrine as the first-line vasopressor during pregnancy and the postpartum period in sepsis with persistent hypotension and/or hypoperfusion despite fluid resuscitation (GRADE 1C); (7) we recommend against immediate delivery for the sole indication of sepsis and that delivery should be dictated by obstetric indications (GRADE 1B). Read More

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http://dx.doi.org/10.1016/j.ajog.2019.01.216DOI Listing
April 2019
5 Reads

Is the placental proteome impaired in well-controlled gestational diabetes?

J Mass Spectrom 2019 Apr;54(4):359-365

Department of Medicine - DIMED, University of Padova, Padova, Italy.

In pregnancy complicated by gestational diabetes mellitus (GDM), the human placenta shows several pathological functional and structural changes, but the extent to which maternal glycemic control contributes to placental abnormalities remains unclear. The aim of this study was to profile and compare the proteome of placentas from healthy pregnant women and those with GDM, to investigate the placenta-specific protein composition and possible changes of its function in presence of GDM. Quantitative proteomic analysis, based on LC-MS approach, revealed that higher (approximately 15% increase) levels of galectin 1 and collagen alpha-1 XIV chain (although the difference regarding the latter was at the limit of significance) were present in GDM samples, while heat shock 70 kDa protein 1A/1B was less abundant in GDM placental tissue. Read More

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http://dx.doi.org/10.1002/jms.4336DOI Listing
April 2019
2 Reads

Pregnancy-Associated Plasma Protein-A Accelerates Atherosclerosis by Regulating Reverse Cholesterol Transport and Inflammation.

Circ J 2019 Feb 18;83(3):515-523. Epub 2019 Jan 18.

Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, Medical Research Experiment Center, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China.

Background: Recent studies have suggested that pregnancy-associated plasma protein-A (PAPP-A) is involved in the pathogenesis of atherosclerosis. This study aim is to investigate the role and mechanisms of PAPP-A in reverse cholesterol transport (RCT) and inflammation during the development of atherosclerosis. Methods and Results: PAPP-A was silenced in apolipoprotein E (apoE) mice with administration of PAPP-A shRNA. Read More

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https://www.jstage.jst.go.jp/article/circj/advpub/0/advpub_C
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http://dx.doi.org/10.1253/circj.CJ-18-0700DOI Listing
February 2019
8 Reads

Fathers' reactions over their partner's diagnosis of peripartum cardiomyopathy: A qualitative interview study.

Midwifery 2019 Apr 2;71:42-48. Epub 2019 Jan 2.

Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden. Electronic address:

Background: Fathers' experience of childbirth has been described as both distressing and wonderful, but little has been described in the literature about fathers´ reactions when their partners get life threatening diagnoses such as peripartum cardiomyopathy (PPCM) during the peripartum period.

Aim: To learn more about fathers' reactions over their partner's diagnosis of peripartum cardiomyopathy.

Methods: Fourteen fathers, whose partner was diagnosed with PPCM before or after giving birth, were interviewed. Read More

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http://dx.doi.org/10.1016/j.midw.2019.01.001DOI Listing
April 2019
3 Reads
1.707 Impact Factor

Cardiomyopathies and Congenital Heart Disease in Pregnancy.

Geburtshilfe Frauenheilkd 2018 Dec 14;78(12):1256-1261. Epub 2018 Dec 14.

Klinik für Innere Medizin, Kardiologie, Angiologie und internistische Intensivmedizin, Klinikum der Philipps-Universität, Marburg, Germany.

Pregnancy-associated diseases of the cardiovascular system occur in up to 10% of all pregnancies and the incidence is increasing. Besides congenital heart disease or pre-existing cardiomyopathy in the mother, the clinical focus has moved especially to peripartum cardiomyopathy (PPCM) because of the condition's dramatic clinical course and the identification of the underlying mechanisms. This review article concentrates therefore on PPCM, which occurs either in the last month of pregnancy or in the first 6 months following delivery in women with previously healthy hearts. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0774-8696
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http://dx.doi.org/10.1055/a-0774-8696DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294643PMC
December 2018
14 Reads

Uterine artery pseudoaneurysm requiring embolization in pregnancy: a case report and review of the literature.

CVIR Endovasc 2018 21;1(1):31. Epub 2018 Nov 21.

3Department of Vascular Surgery, St George's University Hospitals NHS Foundation Trust, London, UK.

Background: Uterine Artery Pseudoaneurysm is a rare cause of pelvic pain and haemorrhage in pregnancy. It should be considered in the differential diagnosis of pregnant women presenting with abdominal pain and is readily diagnosed by colour Doppler ultrasound. If left untreated, they may bleed into the peritoneum causing severe pain and haemorrhagic shock and may progress to maternal and fetal death. Read More

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http://dx.doi.org/10.1186/s42155-018-0040-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319527PMC
November 2018
2 Reads

Impact of nonpneumatic antishock garment in the management of patients with hypoperfusion due to massive postpartum hemorrhage.

J Matern Fetal Neonatal Med 2019 Jan 22:1-5. Epub 2019 Jan 22.

b Departament of Health Science, Faculty of Medicine , ICESI University , Cali , Colombia.

Objective: The objective of this article was to compare hemodynamic and perfusion parameters as well as the clinical outcomes in critically ill patients with postpartum hemorrhage (PPH) who received treatment with a nonpneumatic antishock garment (NASG) as part of an intervention package, with a group of patients in similar conditions who did not receive an NASG.

Methods: This observational study analyzed a historic cohort of 154 patients with PPH, secondary hypovolemic shock and signs of hypoperfusion who were admitted to this institution from 2012 to 2015. Group 1 (n= 77) was managed with NASG and Group 2 (n = 77) received interventions other than NASG. Read More

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https://www.tandfonline.com/doi/full/10.1080/14767058.2019.1
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http://dx.doi.org/10.1080/14767058.2019.1568982DOI Listing
January 2019
11 Reads

Early changes of the heat-shock protein 60 to 70 ratio as prediction of miscarriage in pregnancy.

Am J Reprod Immunol 2019 Mar 14;81(3):e13087. Epub 2019 Feb 14.

4th Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Problem: To study the balance of circulating heat shock protein (HSP)60 and HSP70 in pre-term delivery.

Method Of Study: A two-stage approach was used. At first stage, we run retrospective analysis of prospective collected clinical data, and at a second stage, we studied an animal model of pre-term delivery (PTD). Read More

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http://dx.doi.org/10.1111/aji.13087DOI Listing
March 2019
4 Reads

[Clinical characteristics and risk factors in pregnancy with severe community-acquired pneumonia].

Zhonghua Fu Chan Ke Za Zhi 2018 Dec;53(12):842-848

Department of Intensive Care Unit, Foshan Woman and Children Hospital, Southern Medical University, Foshan 528000, China.

To analyze clinical characteristics of severe community-acquired pneumonia during pregnancy and its outcomes, and to explore the relevant risk factors. From September 2012 to September 2017, 324 398 pregnancies admitted in 7 tertiary hospitals were included. Clinical data of 33 cases of pregnancies with severe community-acquired pneumonia (severe pneumonia group) and 214 cases of pregnancies with common community-acquired pneumonia (control group) were reviewed retrospectively, including the clinical information, manifestations, laboratory examinations and pregnancy outcomes. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-567x.2018.12.008DOI Listing
December 2018
7 Reads

A liquid-like organelle at the root of motile ciliopathy.

Elife 2018 12 18;7. Epub 2018 Dec 18.

Department of Molecular Biosciences, University of Texas, Austin, United States.

Motile ciliopathies are characterized by specific defects in cilia beating that result in chronic airway disease, subfertility, ectopic pregnancy, and hydrocephalus. While many patients harbor mutations in the dynein motors that drive cilia beating, the disease also results from mutations in so-called dynein axonemal assembly factors (DNAAFs) that act in the cytoplasm. The mechanisms of DNAAF action remain poorly defined. Read More

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http://dx.doi.org/10.7554/eLife.38497DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349401PMC
December 2018
2 Reads

Exploring Epidemiological Aspects, Distribution of WHO Maternal Near Miss Criteria, and Organ Dysfunction Defined by SOFA in Cases of Severe Maternal Outcome Admitted to Obstetric ICU: A Cross-Sectional Study.

Biomed Res Int 2018 13;2018:5714890. Epub 2018 Nov 13.

Department of Obstetrics and Gynecology, University of Campinas (UNICAMP), Campinas, SP, Brazil.

Objective: To explore the epidemiological aspects, to describe the frequency and distribution of WHO maternal near miss (MNM) criteria and the presence of organ dysfunction and failure measured by the maximum SOFA (Sequential Organ Failure Assessment) score (SOFA max) in cases of severe maternal outcome (SMO).

Methods: In an observational cross-sectional study performed between January 2013 and December 2015, 279 pregnant or postpartum women were admitted to an obstetric ICU (intensive care unit) in Brazil. MNM, maternal death (grouped as SMO), and potentially life-threatening conditions (PLTC) were defined according to WHO criteria. Read More

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http://dx.doi.org/10.1155/2018/5714890DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257901PMC

Antibodies to and reproductive health issues in women with SLE: a case-control study.

Lupus Sci Med 2018 21;5(1):e000293. Epub 2018 Nov 21.

Department of Immunology and Allergy, Lausanne University Hospital, Lausanne, Switzerland.

Background: SLE is an autoimmune condition affecting predominantly women. Little is known regarding infection in women with SLE, which may drive autoimmunity and contribute to obstetrical and vascular complications.

Methods: This single-centre, case-control study set primary endpoint in the comparative seropositivity rate to major outer membrane protein (MOMP) and chlamydial heat-shock protein-60 (cHSP60) in age-matched subjects. Read More

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http://lupus.bmj.com/lookup/doi/10.1136/lupus-2018-000293
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http://dx.doi.org/10.1136/lupus-2018-000293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257378PMC
November 2018
12 Reads

PHYSIOLOGY SYMPOSIUM: Postnatal consequences of in utero heat stress in pigs.

J Anim Sci 2019 Feb;97(2):962-971

Iowa State University Department of Animal Science, Ames, IA.

Postnatal heat stress negatively impacts pig productivity and well-being as animals attempt to manage the resultant strain response. This is especially true when postnatal heat stress is combined with production stressors (e.g. Read More

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http://dx.doi.org/10.1093/jas/sky472DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358235PMC
February 2019
1 Read

Hydrogen peroxide-mediated oxidative stress induces inflammasome activation in term human placental explants.

Pregnancy Hypertens 2018 Oct 27;14:29-36. Epub 2018 Jul 27.

Department of Gynaecology and Obstetrics, Medical School, Botucatu Sao Paulo State University (Unesp), 18618-970 Sao Paulo, Brazil.

Background: The placenta is a multifunctional organ that can suffer with imbalances between pro- and antioxidant molecules, contributing for inflammatory imbalance. The inflammation generated by oxidative stress may induce inflammasome activation, an essential complex for pro-inflammatory cytokine production.

Objective: The aim of this study was to evaluate whether hydrogen peroxide (HO) mediated oxidative stress induces inflammasome activation on placental explants. Read More

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http://dx.doi.org/10.1016/j.preghy.2018.07.006DOI Listing
October 2018
5 Reads

Post-partum catastrophic antiphospholipid syndrome presenting with shock and digital ischaemia - A diagnostic and management challenge.

J Intensive Care Soc 2018 Nov 19;19(4):357-364. Epub 2018 Mar 19.

Intensive Care Medicine, Nepean Hospital, Kingswood, NSW, Australia.

Catastrophic antiphospholipid syndrome is a rare multisystem autoimmune condition characterised by rapid development of widespread thrombotic disease and subsequent multi-organ failure. It is the most severe complication of antiphospholipid syndrome, carrying significant morbidity and mortality. We report a patient with post-partum catastrophic antiphospholipid syndrome with cardiac, hepatic, renal and cutaneous manifestations. Read More

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http://dx.doi.org/10.1177/1751143718762343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259081PMC
November 2018
3 Reads

Fatal ruptured ectopic pregnancy - a case report.

Med Leg J 2019 Mar 29;87(1):38-41. Epub 2018 Nov 29.

Department of Forensic Medicine, M.S. Ramaiah Medical College, Bangalore, India.

A 26-year-old unmarried female with a history of acute abdominal pain and bleeding per vagina was brought unresponsive to the hospital. She was in shock on arrival and could not be resuscitated. Death was registered as a medico-legal case. Read More

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http://dx.doi.org/10.1177/0025817218795337DOI Listing
March 2019
9 Reads

Alarmins at the maternal-fetal interface: involvement of inflammation in placental dysfunction and pregnancy complications .

Can J Physiol Pharmacol 2019 Mar 28;97(3):206-212. Epub 2018 Nov 28.

a Ste-Justine Hospital Research Center, Department of Obstetrics and Gynecology, Université de Montréal, Montreal, QC H3T 1J4, Canada.

Inflammation is known to be associated with placental dysfunction and pregnancy complications. Infections are well known to be a cause of inflammation but they are frequently undetectable in pregnancy complications. More recently, the focus has been extended to inflammation of noninfectious origin, namely caused by endogenous mediators known as "damage-associated molecular patterns (DAMPs)" or alarmins. Read More

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http://dx.doi.org/10.1139/cjpp-2018-0363DOI Listing
March 2019
2 Reads

CPAF, HSP60 and MOMP antigens elicit pro-inflammatory cytokines production in the peripheral blood mononuclear cells from genital Chlamydia trachomatis-infected patients.

Immunobiology 2019 Jan 20;224(1):34-41. Epub 2018 Nov 20.

Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia; Tropical Infectious Disease Research and Education Center, University of Malaya, 50603 Kuala Lumpur, Malaysia.

Background: Persistent inflammation caused by Chlamydia trachomatis in the female genital compartment represents one of the major causes of pelvic inflammatory disease (PID), ectopic pregnancy and infertility in females. Here, we examined the pro-inflammatory cytokine response following stimulation with three different types of C. trachomatis antigens, viz. Read More

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http://dx.doi.org/10.1016/j.imbio.2018.10.010DOI Listing
January 2019
4 Reads

An audit of the management of ectopic pregnancies in a district hospital, Gauteng, South Africa.

Afr J Prim Health Care Fam Med 2018 Oct 30;10(1):e1-e8. Epub 2018 Oct 30.

Department of Family Medicine and Primary Health Care, Sefako Makgatho Health Sciences University, South Africa; and, Dr George Mukhari Academic Hospital, Ga-Rankuwa.

Background:  Ectopic pregnancy (EP) is a life-threatening condition; at Odi Hospital, approximately 7-10 EPs are managed weekly. Our study is the first to assess the management of this life-threatening condition at Odi Hospital.

Aim:  This study aimed to determine the incidence of EP and to assess the profile of women who presented with EP at Odi District Hospital from 01 January 2010 to 31 December 2014. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244319PMC
http://dx.doi.org/10.4102/phcfm.v10i1.1757DOI Listing
October 2018
31 Reads

[Management and pregnancy outcomes of heterotopic pregnancy].

Zhonghua Fu Chan Ke Za Zhi 2018 Nov;53(11):768-775

Department of Obstetrics, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China.

To investigate the clinical features, diagnosis and treatments of heterotopic pregnancy (HP) and demonstrate the outcomes of HP after the surgical treatment of ectopic pregnancies. A retrospective analysis was performed on 144 cases of HP in Womens Hospital, School of Medicine, Zhejiang University from January 2003 to December 2016. (1) Clinical features of HP:the average age of patients was (30. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-567x.2018.11.007DOI Listing
November 2018
15 Reads

Role of Endoplasmic Reticulum Stress in Proinflammatory Cytokine-Mediated Inhibition of Trophoblast Invasion in Placenta-Related Complications of Pregnancy.

Am J Pathol 2019 Feb 15;189(2):467-478. Epub 2018 Nov 15.

Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom. Electronic address:

Shallow extravillous trophoblast (EVT) invasion is central to the pathophysiology of many pregnancy complications. Invasion is mediated partially by matrix metalloproteinases (MMPs). MMP-2 is highly expressed in early pregnancy. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029440183058
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http://dx.doi.org/10.1016/j.ajpath.2018.10.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360351PMC
February 2019
12 Reads

Interactions of human chorionic gonadotropin with genotype and parity on fertility responses of lactating dairy cows.

J Dairy Sci 2019 Jan 15;102(1):846-856. Epub 2018 Nov 15.

Department of Animal Sciences, D.H. Barron Reproductive and Perinatal Biology Research Program, and Genetics Institute, University of Florida, Gainesville 32611-0910. Electronic address:

Fertility-promoting effects of treatment of lactating dairy cattle with human chorionic gonadotropin (hCG) after artificial insemination (AI) have been variable. Here, we tested whether fertility response to hCG in lactating Holstein cows interacts with genotype and parity. Primiparous (n = 538) and multiparous (n = 613) cows were treated with hCG (3,300 IU) or vehicle 5 d after AI. Read More

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http://dx.doi.org/10.3168/jds.2018-15358DOI Listing
January 2019

Neonatal ethanol exposure impairs long-term context memory formation and prefrontal immediate early gene expression in adolescent rats.

Behav Brain Res 2019 02 14;359:386-395. Epub 2018 Nov 14.

Department of Psychological and Brain Sciences, University of Delaware, Newark, DE, 19716, United States.

Fetal alcohol exposure leads to severe disruptions in learning and memory involving the hippocampus and prefrontal cortex in humans. Animal model research on FASD has documented impairment of hippocampal neuroanatomy and function but animal studies of cognition involving the prefrontal cortex are sparse. We have found that a variant of contextual fear conditioning in which both the hippocampus and prefrontal cortex is required, the Context Preexposure Facilitation Effect (CPFE), is particularly sensitive to neurobehavioral disruption caused by neonatal ethanol exposure during the third trimester equivalent of human pregnancy in the rat (i. Read More

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http://dx.doi.org/10.1016/j.bbr.2018.11.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314039PMC
February 2019
17 Reads

Use of the shock index to predict maternal outcomes in women referred for postpartum hemorrhage.

Int J Gynaecol Obstet 2019 Feb 10;144(2):221-224. Epub 2018 Dec 10.

Department of Obstetrics and Gynecology, Korea University College of Medicine, Seoul, South Korea.

Objective: To evaluate the clinical significance of various vital signs in women referred for postpartum hemorrhage (PPH).

Methods: This retrospective study included patients with primary PPH who were referred to Korea University Medical Center, Ansan, between January 1, 2004, and December 31, 2016. We analyzed data for systolic and diastolic blood pressure, heart rate, and shock index (heart rate divided by systolic blood pressure) at time of arrival. Read More

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http://doi.wiley.com/10.1002/ijgo.12714
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http://dx.doi.org/10.1002/ijgo.12714DOI Listing
February 2019
12 Reads

Incidence and factors associated with outcomes of uterine rupture among women delivered at Felegehiwot referral hospital, Bahir Dar, Ethiopia: cross sectional study.

BMC Pregnancy Childbirth 2018 Nov 16;18(1):447. Epub 2018 Nov 16.

Marie Stops International Ethiopia, Bahir Dar, Ethiopia.

Background: Maternal mortality is a major public health challenge in Ethiopia. Uterine rupture is an obstetrical emergency with serious undesired complications for laboring mothers resulting in fatal maternal and neonatal outcomes. Uterine rupture has been contributing to high maternal morbidity and mortality. Read More

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https://bmcpregnancychildbirth.biomedcentral.com/articles/10
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http://dx.doi.org/10.1186/s12884-018-2083-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240227PMC
November 2018
18 Reads

Ischaemic heart disease and pregnancy.

Heart 2019 02 15;105(3):189-195. Epub 2018 Nov 15.

Academic Department of Obstetrics and Gynaecology, Chelsea and Westminster Hospital, London, UK.

Although ischaemic heart disease is currently rarely encountered in pregnancy, occurring between 2.8 and 6.2 per 100 000 deliveries, it is becoming more common as women delay becoming pregnant until later life, when medical comorbidities are more common, and because of the higher prevalence of obesity in the pregnant population. Read More

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http://heart.bmj.com/lookup/doi/10.1136/heartjnl-2018-313454
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http://dx.doi.org/10.1136/heartjnl-2018-313454DOI Listing
February 2019
21 Reads

[Correlation between shock index and diastolic blood pressure in patients with postpartum hemorrhage and early warning of postpartum hemorrhage risk: an analysis of numerous cases in 4 years].

Authors:
Dexue Zu Yi Zhuge

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2018 Oct;30(10):959-963

Department of Gynaecology and Obstetrics, Affiliated Hospital of Hangzhou Normal University, Hangzhou 310015, Zhejiang, China (Zu DX); Faculty of Medicine, Quzhou Technology College, Quzhou 324000, Zhejiang, China (Zhuge Y). Corresponding author: Zhuge Yi, Email:

Objective: To observe the changes of shock index (SI) and diastolic blood pressure (DBP) in postpartum hemorrhage patients, and the explore their relationship with postpartum hemorrhage and the clinical significance of early warning of hemorrhage risk.

Methods: 402 patients with postpartum hemorrhage (within 24 hours after delivery, the amount of bleeding in vaginal delivery ≥ 500 mL, and the amount of bleeding in caesarean delivery ≥ 1 000 mL) admitted to the obstetrics ward of Affiliated Hospital of Hangzhou Normal University from January 2014 to December 2017 were selected as the objective group and 416 without complications during delivery were selected as the control group in the same hospital at the same period. Clinical data in the two groups before and after childbirth was collected, including age, pregnancy week, 24-hour blood loss, and hemoglobin (Hb), whole blood cell parameters, heart rate (HR), systolic blood pressure (SBP), DBP, SI, blood urea nitrogen (BUN), serum creatinine (SCr) within 24 hours before and after delivery, and postpartum 24 hours and prenatal DBP difference (ΔDBP). Read More

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http://dx.doi.org/10.3760/cma.j.issn.2095-4352.2018.010.011DOI Listing
October 2018
7 Reads

Cardiogenic Shock after Nifedipine Administration in a Pregnant Patient: A Case Report and Review of the Literature.

J Transl Int Med 2018 09 9;6(3):152-156. Epub 2018 Oct 9.

Department of Intensive Care Medicine, Brugmann University Hospital, Université Libre de Bruxelles, Brussels, Belgium.

We present a case of a 21-year-old Caucasian woman at 27 weeks of pregnancy who was admitted to the obstetric department for pre-term labor. She received 10 mg of nifedipine 4 times in 1 h, according to the internal protocol. Shortly after, she brutally deteriorated with pulmonary edema and hypoxemia requiring transfer to the intensive care unit (ICU) for mechanical ventilation. Read More

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http://content.sciendo.com/view/journals/jtim/6/3/article-p1
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http://dx.doi.org/10.2478/jtim-2018-0029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231299PMC
September 2018
22 Reads

Possible mechanisms of prenatal cold stress induced-anxiety-like behavior depression in offspring rats.

Behav Brain Res 2019 02 10;359:304-311. Epub 2018 Nov 10.

College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing, 163319, PR China. Electronic address:

Environmental factors and prenatal stress have long-term effects on offspring behavior, physical development, hypothalamic-pituitary-adrenal (HPA) axis regulation, immune activity, and disease susceptibility. To further understand the effects of prenatal cold stress on offspring, we investigated the behavior change; the expression of glucocorticoid receptor (GR), mineralocorticoid receptor (MR), brain-derived neurotrophic factor (BDNF), insulin-like growth factor 1 receptor (IGF1R), neuronal nuclei (NEUN), glial fibrillary acidic protein (GFAP), corticotropin-releasing hormone receptor 1 (CRHR1), Gamma-aminobutyric acid B receptor, 2 (GABAB2) proteins in hippocampus; the ratio of CD4/CD8 lymphocyte subsets and the level of norepinephrine (NE), dopamine (DA) in the peripheral blood of weaned offspring rats using behavioral tests and biology analysis methods. The results showed that prenatal cold stress affected offspring HPA axis activity, inhibited the expression of MR, BDNF and IGF1R in the hippocampus of male offspring, and lowered the expression of GR in female offspring. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01664328183116
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http://dx.doi.org/10.1016/j.bbr.2018.11.008DOI Listing
February 2019
13 Reads

Distribution of Extreme Vital Signs and Complete Blood Count Values of Healthy Parturients: A Retrospective Database Analysis and Review of the Literature.

Anesth Analg 2018 Nov 9. Epub 2018 Nov 9.

Surgical Intensive Care Department, Shaare Zedek Medical Center, Jerusalem, Israel.

Background: The impact of physiological adjustments throughout pregnancy on maternal vital signs and laboratory values has yet to be fully defined. The present study was designed to determine the normal range of these parameters among healthy pregnant women during the peripartum period.

Methods: This is a retrospective analysis of data collected during real-time deliveries in a single medical center. Read More

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http://dx.doi.org/10.1213/ANE.0000000000003866DOI Listing
November 2018
4 Reads

Quantification of Calcyclin and Heat Shock Protein 90 in Sera from Women with and without Preeclampsia by Mass Spectrometry.

Proteomics Clin Appl 2018 Nov 11:e1800181. Epub 2018 Nov 11.

Laboratory of Neuro-Oncology/Clinical and Cancer Proteomics, Department of Neurology, Erasmus University Medical Center Rotterdam, 3015 CN, Rotterdam, The Netherlands.

Purpose: The objective of present study is to determine serum levels and placental distribution of two interacting proteins calcyclin and heat shock protein 90 in preeclampsia.

Experimental Design: Maternal serum levels of calcyclin and heat shock protein 90 are compared throughout pregnancy from the first trimester till term among women with preeclampsia (n = 43) and age-matched normotensive pregnant controls (n = 46). A serum-based 2D LC-MS assay using Parallel Reaction Monitoring is applied to quantify both calcyclin and heat shock protein 90. Read More

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http://doi.wiley.com/10.1002/prca.201800181
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http://dx.doi.org/10.1002/prca.201800181DOI Listing
November 2018
13 Reads

Ectopic Pregnancy: Risk Factors, Clinical Presentation and Management.

J Obstet Gynaecol India 2018 Dec 18;68(6):487-492. Epub 2017 Nov 18.

Department of Obstetrics and Gynaecology, Sri Ramachandra Medical College and Research Institute, Chennai, 600097 India.

Background: Ectopic pregnancy is increasing in incidence. Nevertheless, there is wide availability of tools for early diagnosis and advances in management. Though it is not a leading cause of maternal mortality, it significantly causes morbidity and jeopardizes reproductive outcome in women desirous of fertility. Read More

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http://link.springer.com/10.1007/s13224-017-1075-3
Publisher Site
http://dx.doi.org/10.1007/s13224-017-1075-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207546PMC
December 2018
17 Reads

Isolated Mesenteric Injury causing Ileal Devascularisation with Uterine Perforation following Termination of Pregnancy; A Case Report and Literature Review.

Bull Emerg Trauma 2018 Oct;6(4):376-378

Dr Hemashree K, House Surgeon, Department of Surgery, BGS GIMS, Bangalore, 560060.

Surgical abortion is one of the leading causes of maternal mortality, constituting up to 20% of maternal deaths. Uterine perforation is a rare complication, accounting for4% of all the abortion related complications. Intestinal injury with uterine perforation following termination of pregnancy is even rare and is a potentially fatal complication with mortality of up to 10%. Read More

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https://www.beat-journal.com/index.php/BEAT/article/view/655
Publisher Site
http://dx.doi.org/10.29252/beat-060418DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215067PMC
October 2018
12 Reads

Retroperitoneal Ectopic Pregnancy.

Obstet Gynecol 2018 Dec;132(6):1491-1493

Department of Obstetrics and Gynecology, WONDOOR Global Health Fellowship, University Hospitals Cleveland Medical Centers, Cleveland, Ohio; the Department of Obstetrics and Gynecology, Boston University School of Medicine, Boston, Massachusetts; the Department of Obstetrics and Gynecology, Georgetown Public Hospital Corporation, Guyana, South America; and Case Western Reserve University School of Medicine, Cleveland, Ohio.

Background: Retroperitoneal ectopic pregnancies are rare and have a tendency to implant along major vessels of the abdomen and pelvis. Clinical manifestations can vary from no symptoms to hypovolemic shock and death.

Case: A 30-year-old woman presented in hypovolemic shock with left flank and abdominal pain after attempting to medically terminate her first-trimester pregnancy. Read More

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http://Insights.ovid.com/crossref?an=00006250-900000000-9787
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http://dx.doi.org/10.1097/AOG.0000000000002965DOI Listing
December 2018
2 Reads

Comparing women's financial costs of induced abortion at a facility vs. seeking treatment for complications from unsafe abortion in Zambia.

Reprod Health Matters 2018 Dec;26(52):1522195

f Head of Obstetrics and Gynaecology-UTH-Lusaka, Department of Obstetrics and Gynaecology, School of Medicine , University of Zambia , Lusaka , Zambia.

Although abortion is legal in Zambia under a variety of broad conditions, unsafe abortion remains common. The purpose of this project was to compare the financial costs for women when they have an induced abortion at a facility, with costs for an induced abortion outside a facility, followed by care for abortion-related complications. We gathered household wealth data at one point in time (T1) and longitudinal qualitative data at two points in time (T1 and T2, three-four months later), in Lusaka and Kafue districts, between 2014 and 2015. Read More

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http://dx.doi.org/10.1080/09688080.2018.1522195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331180PMC
December 2018
1 Read

Postpartum Methicillin-Resistant Toxic Shock Syndrome Caused by a Perineal Infection.

Case Rep Obstet Gynecol 2018 30;2018:2670179. Epub 2018 Sep 30.

Department of Obstetrics and Gynecology, Hashimoto Municipal Hospital, Wakayama, Japan.

Although toxic shock syndrome (TSS) is rare, multiorgan failure can occur without early identification and appropriate therapy. In particular, a few cases of postpartum TSS due to methicillin-resistant (MRSA) have been reported. Here, we describe a rare case in which a 32-year-old Japanese woman had TSS due to MRSA that was caused by a perineal infection after a normal vaginal delivery. Read More

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https://www.hindawi.com/journals/criog/2018/2670179/
Publisher Site
http://dx.doi.org/10.1155/2018/2670179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186360PMC
September 2018
18 Reads

Spontaneous premature birth as a target of genomic research.

Pediatr Res 2019 Mar 18;85(4):422-431. Epub 2018 Sep 18.

PEDEGO Research Unit, Medical Research Center Oulu, University of Oulu, and Department of Children and Adolescents, Oulu University Hospital, Oulu, Finland.

Spontaneous preterm birth is a serious and common pregnancy complication associated with hormonal dysregulation, infection, inflammation, immunity, rupture of fetal membranes, stress, bleeding, and uterine distention. Heredity is 25-40% and mostly involves the maternal genome, with contribution of the fetal genome. Significant discoveries of candidate genes by genome-wide studies and confirmation in independent replicate populations serve as signposts for further research. Read More

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http://dx.doi.org/10.1038/s41390-018-0180-zDOI Listing
March 2019
7 Reads

Heat stress abatement during the postpartum period: effects on whole lactation milk yield, indicators of metabolic status, inflammatory cytokines, and biomarkers of the oxidative stress.

J Anim Sci 2019 Jan;97(1):122-132

Department of the Sciences of Agriculture, Food and Environment (SAFE), University of Foggia, Via Napoli, Foggia, Italy.

The objective of this study was to determine the effect of cooling upon calving in alleviating the adverse effects of heat stress in Holstein lactating cows. Production performance, indicators of metabolic status, immune response, and biomarkers of oxidative stress were measured. Based on mature equivalent milk production, parity, and calving date, 46 multiparous lactating cows were allotted to groups of equal sizes (n = 23); heat stressed (HS; BW = 658 ± 28 kg [mean ± SD]; BCS = 2. Read More

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https://academic.oup.com/jas/advance-article/doi/10.1093/jas
Publisher Site
http://dx.doi.org/10.1093/jas/sky408DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313133PMC
January 2019
6 Reads

Technical note: Developing a heat stress model in dairy cows using an electric heat blanket.

J Dairy Sci 2019 Jan 19;102(1):684-689. Epub 2018 Oct 19.

Department of Animal Science, Iowa State University, Ames 50011. Electronic address:

Precisely studying the biological consequences of heat stress (HS) in agriculturally relevant animals typically requires expensive climate-controlled facilities, infrastructure inaccessible to most researchers. Thus, study objectives were to explore the efficacy of an electric heat blanket (EHB) as an alternative method for evaluating HS and to determine whether EHB-induced hyperthermia affects production parameters similar to natural HS. Lactating Holstein cows (n = 8; 133 ± 3 d in milk; 709 ± 31 kg; 2. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00220302183098
Publisher Site
http://dx.doi.org/10.3168/jds.2018-15128DOI Listing
January 2019
12 Reads

Effects of source on bioavailability of selenium, antioxidant status, and performance in lactating dairy cows during oxidative stress-inducing conditions.

J Dairy Sci 2019 Jan 19;102(1):311-319. Epub 2018 Oct 19.

Institute of Animal Science, State Key Laboratory of Animal Nutrition, Chinese Academy of Agricultural Sciences, Beijing 100193, China; Chinese Academy of Agricultural Sciences-World Agroforestry Centre (CAAS-ICRAF) Joint Lab on Agroforestry and Sustainable Animal Husbandry, World Agroforestry Centre, East and Central Asia, Beijing 100193, China; Hunan Co-Innovation Center of Animal Production Safety (CICAPS), Changsha, Hunan 410128, China. Electronic address:

In the current study, we used heat stress (HS) as an oxidative stress model to examine the effects of hydroxy-selenomethionine (HMSeBA), an organic selenium source, on selenium's bioavailability, antioxidant status, and performance when fed to dairy cows. Eight mid-lactation Holstein dairy cows (141 ± 27 d in milk, 35.3 ± 2. Read More

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http://dx.doi.org/10.3168/jds.2018-14974DOI Listing
January 2019
2 Reads

Implementation project of the non-pneumatic anti-shock garment and m-communication to enhance maternal health care in rural Tanzania.

Reprod Health 2018 Oct 19;15(1):177. Epub 2018 Oct 19.

University of California, San Francisco, School of Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, Safe Motherhood Program, California, USA.

Background: Obstetric hemorrhage (OH) remains one of the leading causes of maternal mortality, particularly in rural Africa. Tanzania has a high maternal mortality ratio, and approximately 80% of the population accesses health care lower level facilities, unable to provide Comprehensive Emergency Obstetric Care (CEmOC). The non-pneumatic anti-shock garment (NASG) has been demonstrated to reduce mortality as it buys time for women in shock to be transported to or to overcome delays at referral facilities. Read More

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http://dx.doi.org/10.1186/s12978-018-0613-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6194579PMC
October 2018
5 Reads