4,994 results match your criteria Shock and Pregnancy


Impact of nonpneumatic antishock garment in the management of patients with hypoperfusion due to massive postpartum hemorrhage.

J Matern Fetal Neonatal Med 2019 Jan 11:1-171. Epub 2019 Jan 11.

b Department of Health Sciences , ICESI University , valle del cauca , Colombia.

Objective: The objective of this article was to compare hemodynamic and perfusion parameters as well as the clinical outcomes in critically ill patients with postpartum hemorrhage (PPH) who received treatment with a nonpneumatic antishock garment (NASG) as part of an intervention package, with a group of patients in similar conditions who did not receive a NASG.

Methods: This observational study analyzed a historic cohort of 154 patients with PPH, secondary hypovolemic shock and signs of hypoperfusion who were admitted in this institution from 2012 to 2015. Group 1 (n = 77) was managed with NASG and Group 2 (n = 77) received interventions other than NASG. Read More

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https://www.tandfonline.com/doi/full/10.1080/14767058.2019.1
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http://dx.doi.org/10.1080/14767058.2019.1568982DOI Listing
January 2019
1 Read

Early changes of the heat-shock protein 60 to 70 ratio as prediction of miscarriage in pregnancy.

Am J Reprod Immunol 2019 Jan 4:e13087. Epub 2019 Jan 4.

4th Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, Athens, Greece.

Problem: To study the balance of circulating heat shock protein (HSP)60 and HSP70 in preterm delivery METHOD OF STUDY: A two-stage approach was used. At first stage we run retrospective analysis of prospective collected clinical data and at a second stage we studied an animal model of preterm delivery (PTD). Blood samples were collected for prenatal screening in 3,629 women. Read More

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http://dx.doi.org/10.1111/aji.13087DOI Listing
January 2019

[Clinical characteristics and risk factors in pregnancy with severe community-acquired pneumonia].

Zhonghua Fu Chan Ke Za Zhi 2018 Dec;53(12):842-848

Department of Intensive Care Unit, Foshan Woman and Children Hospital, Southern Medical University, Foshan 528000, China.

To analyze clinical characteristics of severe community-acquired pneumonia during pregnancy and its outcomes, and to explore the relevant risk factors. From September 2012 to September 2017, 324 398 pregnancies admitted in 7 tertiary hospitals were included. Clinical data of 33 cases of pregnancies with severe community-acquired pneumonia (severe pneumonia group) and 214 cases of pregnancies with common community-acquired pneumonia (control group) were reviewed retrospectively, including the clinical information, manifestations, laboratory examinations and pregnancy outcomes. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-567x.2018.12.008DOI Listing
December 2018
2 Reads

Antibodies to and reproductive health issues in women with SLE: a case-control study.

Lupus Sci Med 2018 21;5(1):e000293. Epub 2018 Nov 21.

Department of Immunology and Allergy, Lausanne University Hospital, Lausanne, Switzerland.

Background: SLE is an autoimmune condition affecting predominantly women. Little is known regarding infection in women with SLE, which may drive autoimmunity and contribute to obstetrical and vascular complications.

Methods: This single-centre, case-control study set primary endpoint in the comparative seropositivity rate to major outer membrane protein (MOMP) and chlamydial heat-shock protein-60 (cHSP60) in age-matched subjects. Read More

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http://lupus.bmj.com/lookup/doi/10.1136/lupus-2018-000293
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http://dx.doi.org/10.1136/lupus-2018-000293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257378PMC
November 2018
5 Reads

Hydrogen peroxide-mediated oxidative stress induces inflammasome activation in term human placental explants.

Pregnancy Hypertens 2018 Oct 27;14:29-36. Epub 2018 Jul 27.

Department of Gynaecology and Obstetrics, Medical School, Botucatu Sao Paulo State University (Unesp), 18618-970 Sao Paulo, Brazil.

Background: The placenta is a multifunctional organ that can suffer with imbalances between pro- and antioxidant molecules, contributing for inflammatory imbalance. The inflammation generated by oxidative stress may induce inflammasome activation, an essential complex for pro-inflammatory cytokine production.

Objective: The aim of this study was to evaluate whether hydrogen peroxide (HO) mediated oxidative stress induces inflammasome activation on placental explants. Read More

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http://dx.doi.org/10.1016/j.preghy.2018.07.006DOI Listing
October 2018
1 Read

Post-partum catastrophic antiphospholipid syndrome presenting with shock and digital ischaemia - A diagnostic and management challenge.

J Intensive Care Soc 2018 Nov 19;19(4):357-364. Epub 2018 Mar 19.

Intensive Care Medicine, Nepean Hospital, Kingswood, NSW, Australia.

Catastrophic antiphospholipid syndrome is a rare multisystem autoimmune condition characterised by rapid development of widespread thrombotic disease and subsequent multi-organ failure. It is the most severe complication of antiphospholipid syndrome, carrying significant morbidity and mortality. We report a patient with post-partum catastrophic antiphospholipid syndrome with cardiac, hepatic, renal and cutaneous manifestations. Read More

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http://dx.doi.org/10.1177/1751143718762343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259081PMC
November 2018
2 Reads

Fatal ruptured ectopic pregnancy - a case report.

Med Leg J 2018 Nov 29:25817218795337. Epub 2018 Nov 29.

Department of Forensic Medicine, M.S. Ramaiah Medical College, Bangalore, India.

A 26-year-old unmarried female with a history of acute abdominal pain and bleeding per vagina was brought unresponsive to the hospital. She was in shock on arrival and could not be resuscitated. Death was registered as a medico-legal case. Read More

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http://dx.doi.org/10.1177/0025817218795337DOI Listing
November 2018
1 Read

Alarmins at the maternal-fetal interface: involvement of inflammation in placental dysfunction and pregnancy complications.

Can J Physiol Pharmacol 2018 Nov 28. Epub 2018 Nov 28.

Universite de Montreal, Obstetrics & Gynecology , 3175 Chemin de la Cote Ste-Catherine , Montreal, Quebec, Canada , H3T1C5.

Inflammation is known to be associated with placental dysfunction and pregnancy complications. Infections are well known to be a cause of inflammation but they are frequently undetectable in pregnancy complications. More recently, the focus has been extended to inflammation of non-infectious origin, namely caused by endogenous mediators known as "damage-associated molecular patterns - DAMPs" or alarmins. Read More

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http://dx.doi.org/10.1139/cjpp-2018-0363DOI Listing
November 2018
1 Read

CPAF, HSP60 and MOMP antigens elicit pro-inflammatory cytokines production in the peripheral blood mononuclear cells from genital Chlamydia trachomatis-infected patients.

Immunobiology 2018 Nov 20. Epub 2018 Nov 20.

Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia; Tropical Infectious Disease Research and Education Center, University of Malaya, 50603 Kuala Lumpur, Malaysia.

Background: Persistent inflammation caused by Chlamydia trachomatis in the female genital compartment represents one of the major causes of pelvic inflammatory disease (PID), ectopic pregnancy and infertility in females. Here, we examined the pro-inflammatory cytokine response following stimulation with three different types of C. trachomatis antigens, viz. Read More

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http://dx.doi.org/10.1016/j.imbio.2018.10.010DOI Listing
November 2018
2 Reads

An audit of the management of ectopic pregnancies in a district hospital, Gauteng, South Africa.

Afr J Prim Health Care Fam Med 2018 Oct 30;10(1):e1-e8. Epub 2018 Oct 30.

Department of Family Medicine and Primary Health Care, Sefako Makgatho Health Sciences University, South Africa; and, Dr George Mukhari Academic Hospital, Ga-Rankuwa.

Background:  Ectopic pregnancy (EP) is a life-threatening condition; at Odi Hospital, approximately 7-10 EPs are managed weekly. Our study is the first to assess the management of this life-threatening condition at Odi Hospital.

Aim:  This study aimed to determine the incidence of EP and to assess the profile of women who presented with EP at Odi District Hospital from 01 January 2010 to 31 December 2014. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244319PMC
http://dx.doi.org/10.4102/phcfm.v10i1.1757DOI Listing
October 2018
16 Reads

[Management and pregnancy outcomes of heterotopic pregnancy].

Zhonghua Fu Chan Ke Za Zhi 2018 Nov;53(11):768-775

Department of Obstetrics, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China.

To investigate the clinical features, diagnosis and treatments of heterotopic pregnancy (HP) and demonstrate the outcomes of HP after the surgical treatment of ectopic pregnancies. A retrospective analysis was performed on 144 cases of HP in Womens Hospital, School of Medicine, Zhejiang University from January 2003 to December 2016. (1) Clinical features of HP:the average age of patients was (30. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-567x.2018.11.007DOI Listing
November 2018
5 Reads

Role of Endoplasmic Reticulum Stress in Proinflammatory Cytokine-Mediated Inhibition of Trophoblast Invasion in Placenta-Related Complications of Pregnancy.

Am J Pathol 2018 Nov 15. Epub 2018 Nov 15.

Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom. Electronic address:

Shallow extravillous trophoblast (EVT) invasion is central to the pathophysiology of many pregnancy complications. Invasion is mediated partially by matrix metalloproteinases (MMPs). MMP-2 is highly expressed in early pregnancy. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029440183058
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http://dx.doi.org/10.1016/j.ajpath.2018.10.015DOI Listing
November 2018
7 Reads

Interactions of human chorionic gonadotropin with genotype and parity on fertility responses of lactating dairy cows.

J Dairy Sci 2019 Jan 15;102(1):846-856. Epub 2018 Nov 15.

Department of Animal Sciences, D.H. Barron Reproductive and Perinatal Biology Research Program, and Genetics Institute, University of Florida, Gainesville 32611-0910. Electronic address:

Fertility-promoting effects of treatment of lactating dairy cattle with human chorionic gonadotropin (hCG) after artificial insemination (AI) have been variable. Here, we tested whether fertility response to hCG in lactating Holstein cows interacts with genotype and parity. Primiparous (n = 538) and multiparous (n = 613) cows were treated with hCG (3,300 IU) or vehicle 5 d after AI. Read More

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http://dx.doi.org/10.3168/jds.2018-15358DOI Listing
January 2019

Neonatal ethanol exposure impairs long-term context memory formation and prefrontal immediate early gene expression in adolescent rats.

Behav Brain Res 2019 02 14;359:386-395. Epub 2018 Nov 14.

Department of Psychological and Brain Sciences, University of Delaware, Newark, DE, 19716, United States.

Fetal alcohol exposure leads to severe disruptions in learning and memory involving the hippocampus and prefrontal cortex in humans. Animal model research on FASD has documented impairment of hippocampal neuroanatomy and function but animal studies of cognition involving the prefrontal cortex are sparse. We have found that a variant of contextual fear conditioning in which both the hippocampus and prefrontal cortex is required, the Context Preexposure Facilitation Effect (CPFE), is particularly sensitive to neurobehavioral disruption caused by neonatal ethanol exposure during the third trimester equivalent of human pregnancy in the rat (i. Read More

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http://dx.doi.org/10.1016/j.bbr.2018.11.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314039PMC
February 2019
4 Reads

Incidence and factors associated with outcomes of uterine rupture among women delivered at Felegehiwot referral hospital, Bahir Dar, Ethiopia: cross sectional study.

BMC Pregnancy Childbirth 2018 Nov 16;18(1):447. Epub 2018 Nov 16.

Marie Stops International Ethiopia, Bahir Dar, Ethiopia.

Background: Maternal mortality is a major public health challenge in Ethiopia. Uterine rupture is an obstetrical emergency with serious undesired complications for laboring mothers resulting in fatal maternal and neonatal outcomes. Uterine rupture has been contributing to high maternal morbidity and mortality. Read More

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https://bmcpregnancychildbirth.biomedcentral.com/articles/10
Publisher Site
http://dx.doi.org/10.1186/s12884-018-2083-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240227PMC
November 2018
8 Reads

Ischaemic heart disease and pregnancy.

Heart 2019 Feb 15;105(3):189-195. Epub 2018 Nov 15.

Academic Department of Obstetrics and Gynaecology, Chelsea and Westminster Hospital, London, UK.

Although ischaemic heart disease is currently rarely encountered in pregnancy, occurring between 2.8 and 6.2 per 100 000 deliveries, it is becoming more common as women delay becoming pregnant until later life, when medical comorbidities are more common, and because of the higher prevalence of obesity in the pregnant population. Read More

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http://heart.bmj.com/lookup/doi/10.1136/heartjnl-2018-313454
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http://dx.doi.org/10.1136/heartjnl-2018-313454DOI Listing
February 2019
6 Reads

[Correlation between shock index and diastolic blood pressure in patients with postpartum hemorrhage and early warning of postpartum hemorrhage risk: an analysis of numerous cases in 4 years].

Authors:
Dexue Zu Yi Zhuge

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2018 Oct;30(10):959-963

Department of Gynaecology and Obstetrics, Affiliated Hospital of Hangzhou Normal University, Hangzhou 310015, Zhejiang, China (Zu DX); Faculty of Medicine, Quzhou Technology College, Quzhou 324000, Zhejiang, China (Zhuge Y). Corresponding author: Zhuge Yi, Email:

Objective: To observe the changes of shock index (SI) and diastolic blood pressure (DBP) in postpartum hemorrhage patients, and the explore their relationship with postpartum hemorrhage and the clinical significance of early warning of hemorrhage risk.

Methods: 402 patients with postpartum hemorrhage (within 24 hours after delivery, the amount of bleeding in vaginal delivery ≥ 500 mL, and the amount of bleeding in caesarean delivery ≥ 1 000 mL) admitted to the obstetrics ward of Affiliated Hospital of Hangzhou Normal University from January 2014 to December 2017 were selected as the objective group and 416 without complications during delivery were selected as the control group in the same hospital at the same period. Clinical data in the two groups before and after childbirth was collected, including age, pregnancy week, 24-hour blood loss, and hemoglobin (Hb), whole blood cell parameters, heart rate (HR), systolic blood pressure (SBP), DBP, SI, blood urea nitrogen (BUN), serum creatinine (SCr) within 24 hours before and after delivery, and postpartum 24 hours and prenatal DBP difference (ΔDBP). Read More

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http://dx.doi.org/10.3760/cma.j.issn.2095-4352.2018.010.011DOI Listing
October 2018
5 Reads

Cardiogenic Shock after Nifedipine Administration in a Pregnant Patient: A Case Report and Review of the Literature.

J Transl Int Med 2018 09 9;6(3):152-156. Epub 2018 Oct 9.

Department of Intensive Care Medicine, Brugmann University Hospital, Université Libre de Bruxelles, Brussels, Belgium.

We present a case of a 21-year-old Caucasian woman at 27 weeks of pregnancy who was admitted to the obstetric department for pre-term labor. She received 10 mg of nifedipine 4 times in 1 h, according to the internal protocol. Shortly after, she brutally deteriorated with pulmonary edema and hypoxemia requiring transfer to the intensive care unit (ICU) for mechanical ventilation. Read More

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http://content.sciendo.com/view/journals/jtim/6/3/article-p1
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http://dx.doi.org/10.2478/jtim-2018-0029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231299PMC
September 2018
11 Reads

Distribution of Extreme Vital Signs and Complete Blood Count Values of Healthy Parturients: A Retrospective Database Analysis and Review of the Literature.

Anesth Analg 2018 Nov 9. Epub 2018 Nov 9.

Surgical Intensive Care Department, Shaare Zedek Medical Center, Jerusalem, Israel.

Background: The impact of physiological adjustments throughout pregnancy on maternal vital signs and laboratory values has yet to be fully defined. The present study was designed to determine the normal range of these parameters among healthy pregnant women during the peripartum period.

Methods: This is a retrospective analysis of data collected during real-time deliveries in a single medical center. Read More

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http://dx.doi.org/10.1213/ANE.0000000000003866DOI Listing
November 2018
3 Reads

Quantification of Calcyclin and Heat Shock Protein 90 in Sera from Women with and without Preeclampsia by Mass Spectrometry.

Proteomics Clin Appl 2018 Nov 11:e1800181. Epub 2018 Nov 11.

Laboratory of Neuro-Oncology/Clinical and Cancer Proteomics, Department of Neurology, Erasmus University Medical Center Rotterdam, 3015 CN, Rotterdam, The Netherlands.

Purpose: The objective of present study is to determine serum levels and placental distribution of two interacting proteins calcyclin and heat shock protein 90 in preeclampsia.

Experimental Design: Maternal serum levels of calcyclin and heat shock protein 90 are compared throughout pregnancy from the first trimester till term among women with preeclampsia (n = 43) and age-matched normotensive pregnant controls (n = 46). A serum-based 2D LC-MS assay using Parallel Reaction Monitoring is applied to quantify both calcyclin and heat shock protein 90. Read More

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http://doi.wiley.com/10.1002/prca.201800181
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http://dx.doi.org/10.1002/prca.201800181DOI Listing
November 2018
4 Reads

Ectopic Pregnancy: Risk Factors, Clinical Presentation and Management.

J Obstet Gynaecol India 2018 Dec 18;68(6):487-492. Epub 2017 Nov 18.

Department of Obstetrics and Gynaecology, Sri Ramachandra Medical College and Research Institute, Chennai, 600097 India.

Background: Ectopic pregnancy is increasing in incidence. Nevertheless, there is wide availability of tools for early diagnosis and advances in management. Though it is not a leading cause of maternal mortality, it significantly causes morbidity and jeopardizes reproductive outcome in women desirous of fertility. Read More

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http://link.springer.com/10.1007/s13224-017-1075-3
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http://dx.doi.org/10.1007/s13224-017-1075-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207546PMC
December 2018
10 Reads

Isolated Mesenteric Injury causing Ileal Devascularisation with Uterine Perforation following Termination of Pregnancy; A Case Report and Literature Review.

Bull Emerg Trauma 2018 Oct;6(4):376-378

Dr Hemashree K, House Surgeon, Department of Surgery, BGS GIMS, Bangalore, 560060.

Surgical abortion is one of the leading causes of maternal mortality, constituting up to 20% of maternal deaths. Uterine perforation is a rare complication, accounting for4% of all the abortion related complications. Intestinal injury with uterine perforation following termination of pregnancy is even rare and is a potentially fatal complication with mortality of up to 10%. Read More

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https://www.beat-journal.com/index.php/BEAT/article/view/655
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http://dx.doi.org/10.29252/beat-060418DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215067PMC
October 2018
8 Reads

Retroperitoneal Ectopic Pregnancy.

Obstet Gynecol 2018 Dec;132(6):1491-1493

Department of Obstetrics and Gynecology, WONDOOR Global Health Fellowship, University Hospitals Cleveland Medical Centers, Cleveland, Ohio; the Department of Obstetrics and Gynecology, Boston University School of Medicine, Boston, Massachusetts; the Department of Obstetrics and Gynecology, Georgetown Public Hospital Corporation, Guyana, South America; and Case Western Reserve University School of Medicine, Cleveland, Ohio.

Background: Retroperitoneal ectopic pregnancies are rare and have a tendency to implant along major vessels of the abdomen and pelvis. Clinical manifestations can vary from no symptoms to hypovolemic shock and death.

Case: A 30-year-old woman presented in hypovolemic shock with left flank and abdominal pain after attempting to medically terminate her first-trimester pregnancy. Read More

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http://Insights.ovid.com/crossref?an=00006250-900000000-9787
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http://dx.doi.org/10.1097/AOG.0000000000002965DOI Listing
December 2018
1 Read

Comparing women's financial costs of induced abortion at a facility vs. seeking treatment for complications from unsafe abortion in Zambia.

Reprod Health Matters 2018 Dec;26(52):1522195

f Head of Obstetrics and Gynaecology-UTH-Lusaka, Department of Obstetrics and Gynaecology, School of Medicine , University of Zambia , Lusaka , Zambia.

Although abortion is legal in Zambia under a variety of broad conditions, unsafe abortion remains common. The purpose of this project was to compare the financial costs for women when they have an induced abortion at a facility, with costs for an induced abortion outside a facility, followed by care for abortion-related complications. We gathered household wealth data at one point in time (T1) and longitudinal qualitative data at two points in time (T1 and T2, three-four months later), in Lusaka and Kafue districts, between 2014 and 2015. Read More

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http://dx.doi.org/10.1080/09688080.2018.1522195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331180PMC
December 2018
1 Read

Postpartum Methicillin-Resistant Toxic Shock Syndrome Caused by a Perineal Infection.

Case Rep Obstet Gynecol 2018 30;2018:2670179. Epub 2018 Sep 30.

Department of Obstetrics and Gynecology, Hashimoto Municipal Hospital, Wakayama, Japan.

Although toxic shock syndrome (TSS) is rare, multiorgan failure can occur without early identification and appropriate therapy. In particular, a few cases of postpartum TSS due to methicillin-resistant (MRSA) have been reported. Here, we describe a rare case in which a 32-year-old Japanese woman had TSS due to MRSA that was caused by a perineal infection after a normal vaginal delivery. Read More

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https://www.hindawi.com/journals/criog/2018/2670179/
Publisher Site
http://dx.doi.org/10.1155/2018/2670179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186360PMC
September 2018
6 Reads

Spontaneous premature birth as a target of genomic research.

Pediatr Res 2018 Sep 18. Epub 2018 Sep 18.

PEDEGO Research Unit, Medical Research Center Oulu, University of Oulu, and Department of Children and Adolescents, Oulu University Hospital, Oulu, Finland.

Spontaneous preterm birth is a serious and common pregnancy complication associated with hormonal dysregulation, infection, inflammation, immunity, rupture of fetal membranes, stress, bleeding, and uterine distention. Heredity is 25-40% and mostly involves the maternal genome, with contribution of the fetal genome. Significant discoveries of candidate genes by genome-wide studies and confirmation in independent replicate populations serve as signposts for further research. Read More

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http://dx.doi.org/10.1038/s41390-018-0180-zDOI Listing
September 2018
4 Reads

Implementation project of the non-pneumatic anti-shock garment and m-communication to enhance maternal health care in rural Tanzania.

Reprod Health 2018 Oct 19;15(1):177. Epub 2018 Oct 19.

University of California, San Francisco, School of Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, Safe Motherhood Program, California, USA.

Background: Obstetric hemorrhage (OH) remains one of the leading causes of maternal mortality, particularly in rural Africa. Tanzania has a high maternal mortality ratio, and approximately 80% of the population accesses health care lower level facilities, unable to provide Comprehensive Emergency Obstetric Care (CEmOC). The non-pneumatic anti-shock garment (NASG) has been demonstrated to reduce mortality as it buys time for women in shock to be transported to or to overcome delays at referral facilities. Read More

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http://dx.doi.org/10.1186/s12978-018-0613-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6194579PMC
October 2018
2 Reads

Thrombolysis for pulmonary embolism during pregnancy . About four cases.

Tunis Med 2018 Jan;96(1):80-83

Pregnancy is correlated with a significant increase in the risk of pulmonary embolism (PE) given the physiological changes in fibrinolysis and mechanical stress induced by the pregnant uterus. Our goal is to demonstrate through four cases of massive bilateral PE occurred during pregnancy, the possibility of thrombolysis in pregnant women. We report the observation of four pregnant patients, between 28 and 38 years old and whose term varies between nine and 36 last menstrual period, hospitalized for serious PE complicated by cardiorespiratory arrest in one case and haemodynamic instability in other cases. Read More

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January 2018
10 Reads

Epigenetics and the vaginal microbiome: influence of the microbiota on the histone deacetylase level in vaginal epithelial cells from pregnant women.

Minerva Ginecol 2018 Oct 11. Epub 2018 Oct 11.

Department of Biological Sciences and the Institute for Bioinformatics and Evolutionary Studies, University of Idaho, Moscow, ID, USA.

Histone deacetylase (HDAC) influences the acetylation status of histones at gene promotor loci, providing an epigenetic mechanism that regulates gene expression. We determined if variations in the composition of the vaginal microbiome in pregnant women were associated with alterations in the level of HDAC1 in vaginal epithelial cells and whether this influenced the concentration of compounds present in vaginal fluid. Vaginal epithelial cells were obtained from 150 women in their first trimester of pregnancy, lysed and assayed for HDAC1 by ELISA. Read More

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http://dx.doi.org/10.23736/S0026-4784.18.04322-8DOI Listing
October 2018
2 Reads

Emergent caesarean section under mechanical circulatory support for acute severe peripartum cardiomyopathy.

J Cardiol Cases 2018 Jun 21;17(6):200-203. Epub 2018 Mar 21.

Oita Prefectural Hospital, Oita-ken, Japan.

Peripartum cardiomyopathy (PPCM) is an idiopathic left ventricular dysfunction in women who are in late pregnancy or the postpartum period. PPCM is a rare but sometimes fatal disease, and mechanical circulatory support is required if heart failure is refractory to conventional therapy. A 28-year-old woman in late pregnancy was admitted to our hospital due to congestive heart failure with cardiogenic shock. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18785409183001
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http://dx.doi.org/10.1016/j.jccase.2018.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149581PMC
June 2018
2 Reads

Need for guidelines for the combined management of pregnancy and dengue: a retrospective study from an Indian tertiary care maternity hospital.

Trop Doct 2018 Sep 30:49475518800638. Epub 2018 Sep 30.

Consultant obstetrician, Department of Obstetrics, Fernandez Hospital, Telangana, Hyderabad, India.

The incidence of dengue has risen in India in recent years. Evidence suggests that dengue in pregnancy may be associated with adverse maternal and fetal outcomes. The aim of our study was to analyse outcomes in pregnant women with confirmed dengue infection who had the benefit of close monitoring and intensive management at a tertiary maternity facility. Read More

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http://dx.doi.org/10.1177/0049475518800638DOI Listing
September 2018
5 Reads

The impact of early life shocks on human capital formation: evidence from El Niño floods in Ecuador.

J Health Econ 2018 Nov 17;62:13-44. Epub 2018 Aug 17.

Rutgers University, Department of Economics, 360 Martin Luther King Jr. Blvd Newark, NJ 07102, United States. Electronic address:

This paper investigates the persistent effects of negative shocks in utero and in infancy on low-income children's health and cognitive outcomes and examines whether timing of exposure matters differentially by skill type. Specifically, I exploit the geographic intensity of extreme floods in Ecuador during the 1997-1998 El Niño phenomenon, which provides exogenous variation in exposure at different periods of early development. I show that children exposed to severe floods in utero, especially during the third trimester, are shorter in stature five and seven years later. Read More

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http://dx.doi.org/10.1016/j.jhealeco.2018.07.003DOI Listing
November 2018
1 Read

Resuscitative endovascular balloon occlusion of the aorta deployed by acute care surgeons in patients with morbidly adherent placenta: a feasible solution for two lives in peril.

World J Emerg Surg 2018 24;13:44. Epub 2018 Sep 24.

3Trauma and Acute Care Surgery Division, Department of Surgery, Fundacion Valle del Lili, Cali, Colombia.

Morbidly adherent placenta (MAP), which includes accreta, increta, and percreta, is a condition characterized by the invasion of the uterine wall by placental tissue. The condition is associated with higher odds of massive post-partum hemorrhage. Several interventions have been developed to improve hemorrhage-related outcomes in these patients; however, there is no evidence to prefer any intervention over another. Read More

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http://dx.doi.org/10.1186/s13017-018-0205-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154816PMC
January 2019
11 Reads

Complete Myocardial Function Recovery with ECMO in a Woman Presenting with Cardiogenic Shock during Peripartum Period.

J Extra Corpor Technol 2018 09;50(3):189-192

NewYork-Presbyterian Brooklyn Methodist Hospital, Brooklyn, New York.

Peripartum cardiomyopathy is a potentially life-threatening cause of heart failure (HF) that affects women toward the end of pregnancy or in months after delivery. Treatment is similar to the treatment for HF with reduced ejection fraction (EF). Most women make full myocardial function recovery within 6 months on conventional HF therapy. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146275PMC
September 2018
6 Reads

Maternal and environmental risk factors for neonatal AKI and its long-term consequences.

Nat Rev Nephrol 2018 Nov;14(11):688-703

Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Bergamo, Italy.

Acute kidney injury (AKI) is a common and life-threatening complication in critically ill neonates. Gestational risk factors for AKI include premature birth, intrauterine growth restriction and low birthweight, which are associated with poor nephron development and are often the consequence of pre-gestational and gestational factors, such as poor nutritional status. Our understanding of how to best optimize renal development and prevent AKI is in its infancy; however, the identification of pre-gestational and gestational factors that increase the risk of adverse neonatal outcomes and the implementation of interventions, such as improving nutritional status early in pregnancy, have the potential to optimize fetal growth and reduce the risk of preterm birth, thereby improving kidney health. Read More

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http://dx.doi.org/10.1038/s41581-018-0054-yDOI Listing
November 2018
18 Reads

Maternal anaphylactic shock in pregnancy: A case report.

Medicine (Baltimore) 2018 Sep;97(37):e12351

Anesthesiology and Pain Medicine, Soonchunhyang University College of Medicine, Soonchunhyang University Cheonan Hospital, Cheonan, Korea.

Rationale: Anaphylaxis is a very rare event in pregnancy, triggering maternal hypotension leading to intrapartum hypoxic-ischemic encephalopathy in infant. Furthermore, cesarean sections are performed at a high rate in anaphylactic pregnant women.

Patient Concerns: A 34-year-old pregnant woman presented with maternal anaphylaxis following prophylactic antibiotic injection for cesarean section. Read More

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http://Insights.ovid.com/crossref?an=00005792-201809140-0006
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http://dx.doi.org/10.1097/MD.0000000000012351DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156050PMC
September 2018
18 Reads

Methods for blood loss estimation after vaginal birth.

Cochrane Database Syst Rev 2018 09 13;9:CD010980. Epub 2018 Sep 13.

Centro Rosarino de Estudios Perinatales (CREP), Moreno 878, 6to piso, Rosario, Santa Fe, Argentina, S2000DKR.

Background: Almost 358,000 women die each year in childbirth, mainly in low-income countries. More than half of all maternal deaths occur within 24 hours of giving birth; severe bleeding in the postpartum period is the single most important cause. Depending on the rate of blood loss and other factors, such as pre-existing anaemia, untreated postpartum haemorrhage (PPH) can lead to hypovolaemic shock, multi-organ dysfunction, and maternal death, within two to six hours. Read More

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http://doi.wiley.com/10.1002/14651858.CD010980.pub2
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http://dx.doi.org/10.1002/14651858.CD010980.pub2DOI Listing
September 2018
8 Reads

Rapid onset of severe septic shock in the pregnant mouse.

Biol Reprod 2018 Sep 3. Epub 2018 Sep 3.

Chelsea and Westminster Hospital, 369 Fulham Road, London, SW10 9NH, UK.

Aims: Globally, sepsis is a major cause of mortality through the combination of cardiovascular collapse and multi-organ dysfunction. Pregnancy appears to increase the risk of death in sepsis, but the exact reason for the greater severity is unclear. In this study, we used polymicrobial sepsis induced by caecal ligation and puncture (CLP) and high-dose intraperitoneal lipopolysaccharide (LPS; 10 or 40mg, serotype 0111: B4) to test the hypotheses that pregnant mice are more susceptible to sepsis and that this susceptibility was mediated through an excessive innate response causing a more severe cardiovascular collapse rather than a reduction in microbe killing. Read More

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http://dx.doi.org/10.1093/biolre/ioy193DOI Listing
September 2018
14 Reads

Peripartum Iliac Arterial Aneurysm and Rupture in a Patient with Vascular Ehlers-Danlos Syndrome Diagnosed by Next-Generation Sequencing.

Int Heart J 2018 Sep 29;59(5):1180-1185. Epub 2018 Aug 29.

Department of Cardiovascular Medicine, Gunma University Graduate School of Medicine.

Vascular Ehlers-Danlos syndrome (vEDS), a genetic disorder caused by mutations in procollagen type III gene (COL3A1), may lead to fatal vascular complication during peripartum period because of the arterial fragility. We experienced a case of vEDS with peripartum life-threatening arterial rapture diagnosed by next-generation sequencing (NGS) and successfully treated the vascular complications. A 25-year-old female in pregnancy at 34 weeks had sudden and acute pain in the left lower abdomen. Read More

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http://dx.doi.org/10.1536/ihj.17-451DOI Listing
September 2018
10 Reads

Retzius space haematoma as a rare cause of concealed retroperitoneal postpartum haemorrhage following spontaneous vaginal delivery.

BMJ Case Rep 2018 Aug 29;2018. Epub 2018 Aug 29.

Emergency Medicine, Logan Hospital, Meadowbrook, Queensland, Australia.

A 34-year-old woman presented to hospital in shock 8 hours after a spontaneous home vaginal delivery. She is a known carrier of haemophilia A. Examination revealed a tender but firm, central and contracted uterus. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22598
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http://dx.doi.org/10.1136/bcr-2018-225980DOI Listing
August 2018
14 Reads

Laparostomy during pregnancy: A case report.

Int J Surg Case Rep 2018 20;51:120-124. Epub 2018 Aug 20.

Serviço de Cirurgia Geral do Centro Hospitalar Tondela-Viseu, Avenida Rei D. Duarte, 3504-509, Viseu, Portugal. Electronic address:

Introduction: Acute appendicitis is the main indication for surgery during pregnancy. Physiologic changes during pregnancy and fear of using ionising radiation exams are some of the reasons to delayed diagnosis and consequently to higher morbidity and mortality rates for mother and fetus.

Presentation Of Case: We present the case of a 38-year-old woman that resorted to the emergency room on the 13th week of pregnancy with abdominal discomfort, nausea and vomiting that lasted for 7 days. Read More

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http://dx.doi.org/10.1016/j.ijscr.2018.08.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6110995PMC
August 2018
3 Reads

Secretion of heat shock -60, -70 kD protein, IL-1β and TNFα levels in serum of a term normal pregnancy and patients with pre-eclampsia development.

J Cell Mol Med 2018 Nov 22;22(11):5748-5752. Epub 2018 Aug 22.

Departamento de Inmunobioquímica, Instituto Nacional de Perinatología "Isidro Espinosa de los Reyes" (INPerIER), Ciudad de México, México.

The extracellular heat shock proteins (eHsp) family act as molecular chaperones regulating folding, transporting protein and are associated with immune modulation in different physiological and pathological processes. They have been localized in different gestational tissues and their concentration in amniotic fluid and serum has been determined. In the present study, we proposed to determine the concentration of eHsp-60, -70, IL-1β and TNFα in the serum of pregnant patients with 34 weeks of gestation with and without clinical evidences of preeclampsia (PE). Read More

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http://dx.doi.org/10.1111/jcmm.13824DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201347PMC
November 2018
2 Reads

Delivery Outcomes, Emergency Room Visits, and Psychological Aspects of Gestational Diabetes: Results From a Community Hospital Multiethnic Cohort.

Diabetes Educ 2018 10 17;44(5):465-474. Epub 2018 Aug 17.

University of California, Irvine, California.

Purpose The purpose of this study was to evaluate perinatal outcomes and experiences of managing gestational diabetes (GDM) in a multiethnic cohort from a community hospital. Methods A retrospective cohort study of 647 ethnically diverse women with GDM was conducted. Multivariable logistic regression models were used to examine ethnic differences in cesarean delivery rates and emergency department (ED) utilization during pregnancy. Read More

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http://dx.doi.org/10.1177/0145721718795589DOI Listing
October 2018
7 Reads

A retrospective cohort study of risk factors and pregnancy outcomes in 14,014 Chinese pregnant women.

Medicine (Baltimore) 2018 Aug;97(33):e11748

Department of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University.

This study aims to investigate major complications or symptoms of pregnant women, causes of maternal near-miss, and issues that are relevant to severe maternal disease.A retrospective analysis was performed in the "maternal individual investigation form," which included all critical maternity patients admitted to the First Affiliated Hospital of Anhui Medical University from January 1, 2012 to September 31, 2015.A total of 14,014 pregnant patients who delivered at 28 to 42 weeks of gestation were included. Read More

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http://dx.doi.org/10.1097/MD.0000000000011748DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6113036PMC
August 2018
3 Reads

Case Fatality and Adverse Outcomes Are Reduced in Pregnant Women With Severe Sepsis or Septic Shock Compared With Age-Matched Comorbid-Matched Nonpregnant Women.

Crit Care Med 2018 Nov;46(11):1775-1782

Department of Obstetrics & Gynaecology, University of British Columbia, Vancouver, BC, Canada.

Objectives: Case fatality in pregnancy-associated severe sepsis or septic shock appears reduced compared with nonpregnant women with severe sepsis or septic shock. It remains unclear if this difference is due to pregnancy or better baseline health status, among others. Our study compared adverse outcomes of pregnancy-associated severe sepsis or septic shock with nonpregnant women with severe sepsis or septic shock while controlling for age and chronic comorbidities. Read More

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http://dx.doi.org/10.1097/CCM.0000000000003348DOI Listing
November 2018
10 Reads

CSDC2, a cold shock domain RNA-binding protein in decidualization.

J Cell Physiol 2018 Jan 4;234(1):740-748. Epub 2018 Aug 4.

Instituto de Biología y Medicina Experimental, IByME-Conicet, Buenos Aires, Argentina.

RNA-binding proteins (RBPs) have been described for cancer cell progression and differentiation, although there is still much to learn about their mechanisms. Here, using in vivo decidualization as a model, we describe the role of RBP cold shock domain containing C2 (CSDC2) in the endometrium. Csdc2 messenger RNA expression was differentially regulated depending on time and areas of decidua development, with the most variation in antimesometrium (AM) and, to a lesser degree, in the junctional zone (JZ). Read More

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http://dx.doi.org/10.1002/jcp.26885DOI Listing
January 2018

Uterine Inversion: A Review of a Life-Threatening Obstetrical Emergency.

Obstet Gynecol Surv 2018 Jul;73(7):411-417

Professor, Maternal-Fetal Medicine Fellowship Director, Department of Obstetrics and Gynecology, University of Arkansas for Medical Sciences, Little Rock, AR.

Importance: Uterine inversion is frequently accompanied by postpartum hemorrhage and hypovolemic shock. Morbidity and mortality occur in as many as 41% of cases. Prompt recognition and management are of utmost importance. Read More

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http://dx.doi.org/10.1097/OGX.0000000000000580DOI Listing
July 2018
2 Reads

Diagnostic point-of-care ultrasound: applications in obstetric anaesthetic management.

Anaesthesia 2018 Oct 26;73(10):1265-1279. Epub 2018 Jul 26.

Department of Anaesthesia and Intensive Care Medicine, University Hospital of Marseille, Marseille, France.

Complications during pregnancy are not frequent, but may occur abruptly. Point-of-care ultrasound is a non-invasive, non-ionising diagnostic tool that is available at the bed-side when complications occur. This review covers the use of ultrasound in various clinical situations. Read More

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http://dx.doi.org/10.1111/anae.14354DOI Listing
October 2018
7 Reads