Search Our Scientific Publications & Authors

Braz J Anesthesiol 2021 Jun 9. Epub 2021 Jun 9.

Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Cirurgia, São Paulo, SP, Brazil.

Background: Sepsis and septic shock still represent great challenges in critical care medicine. Sildenafil has been largely used in the treatment of pulmonary arterial hypertension, but its effects in sepsis are unknown. The aim of this study was to investigate the hypothesis that sildenafil can attenuate endotoxin-induced pulmonary hypertension in a porcine model of endotoxemia. Read More

Cell Death Dis 2021 Jun 11;12(6):606. Epub 2021 Jun 11.

Division of Trauma and Surgical Intensive Care Unit, Research Institute of General Surgery, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, 210002, Jiangsu, P. R. China.

Increased neutrophil extracellular traps (NETs) formation has been found to be associated with intestinal inflammation, and it has been reported that NETs may drive the progression of gut dysregulation in sepsis. However, the biological function and regulation of NETs in sepsis-induced intestinal barrier dysfunction are not yet fully understood. First, we found that both circulating biomarkers of NETs and local NETs infiltration in the intestine were significantly increased and had positive correlations with markers of enterocyte injury in abdominal sepsis patients. Read More

Int J Clin Pract 2021 Jun 11:e14494. Epub 2021 Jun 11.

Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India.

Aim: The primary objective of this article is to understand the various complications caused by the coronavirus in the pediatric population.

Method: An electronic search was conducted using PubMed and incorporated forward and backward research methods on clinical trials, case reports, case series guidelines, and reports from the centre for disease control and prevention (CDC) and the keywords included Covid-19, Paediatrics, Multisystem inflammatory syndrome in children (MIS-C), Complications, Acute kidney injury, Heart failure. Secondary resources included one study from pre-print servers (www. Read More

PLoS One 2021 11;16(6):e0253259. Epub 2021 Jun 11.

Division of Infectious Diseases and Global Medicine, Department of Medicine, University of Florida, Gainesville, Florida, United States of America.

Studies of the outcome of Pseudomonas aeruginosa bacteremia (Pab) have focused mainly on antibiotic appropriateness. However, P. aeruginosa possesses many virulence factors whose roles in outcomes have not been examined in humans, except for the type III secretion system (T3SS) toxins. Read More

Paediatr Int Child Health 2021 Jun 11:1-7. Epub 2021 Jun 11.

Department of Life Sciences and Public Health, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.

Myocardial bridging is largely considered to be a benign, symptomless congenital anomaly of the coronary arteries in which the intramyocardial coronary course is partially 'tunnelled' and leads to vessel compression during ventricular systole. There are few data regarding children. To report on myocardial bridging observed in children seeking medical help in the paediatric emergency room. Read More

Medicine (Baltimore) 2021 Jun;100(23):e26288

Department of Critical Care Medicine, Zhongda Hospital, Southeast University, Nanjing, China.

Abstract: The leukocytes play an important role in immune function during sepsis. We performed a retrospective study to investigate if leukocytes kinetics was associated with survival in critically ill patients with septic shock in intensive care unit (ICU).Patients with septic shock from January 1, 2014 to June 30, 2018 in our ICU were included. Read More

Front Pharmacol 2021 25;12:628825. Epub 2021 May 25.

General Intensive Care Unit, The First Affiliated Hospital of Zhengzhou University, Henan Key Laboratory of Critical Care Medicine, Zhengzhou Key Laboratory of Sepsis, Henan Engineering Research Centre for Critical Care Medicine, Zhengzhou, China.

The aim of this study was to comprehensively review the literature and synthesize the evidence concerning the relationship between prior calcium channel blocker (CCB) use and mortality in patients with sepsis. The Medical Literature Analysis and Retrieval System Online (MEDLINE), Excerpta Medica database (EMBASE), Cochrane CENTRAL, and Web of Science databases were searched from their inception to April 9, 2020. Cohort studies related to prior calcium channel blocker use in patients with sepsis were analyzed. Read More

Acta Med Litu 2020 21;27(2):84-89. Epub 2020 Dec 21.

Department of Obstetrics and Gynecology, General and Teaching Hospital Celje, Slovenia.

Unicornuate uterus with non-communicating rudimentary horn is a type of congenital uterine abnormality that occurs as a consequence of the arrested development of one of the two Müllerian ducts. Patients with unicornuate uterus have increased incidence of obstetric and gynaecological complications. We present a report of a clinical case of a 28-years-old female, who was referred to the hospital for evaluation of her infertility. Read More

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2021 May;33(5):621-625

Department of Critical Care Medicine, the First People's Hospital Affiliated to Shanghai Jiao Tong University, Shanghai 201620, China.

Sepsis is caused by the imbalance of the host body's response to infection, which causes life-threatening organ dysfunction. Disorders of blood coagulation play a very important role in the development of sepsis. In sepsis, the body's coagulation system is activated, leading to hypercoagulability, while the anticoagulation mechanism is significantly inhibited, causing a large number of microthrombi to form, and disseminated intravascular coagulation (DIC) may occur. Read More

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2021 May;33(5):517-522

Department of Critical Care Medicine, Liuzhou People's Hospital, Liuzhou 545006, Guangxi Zhuang Autonomous Region, China. Corresponding author: Zhu Xiaowen, Email:

Objective: To investigate the effect of fluid resuscitation and circulatory support, directed by different target mean arterial pressure (MAP), on abdominal blood flow, gastrointestinal function and inflammatory response in septic shock patients with hypertension.

Methods: A prospective randomized controlled study was conducted. Hypertensive patients with septic shock admitted to the department of intensive care unit (ICU) of Liuzhou People's Hospital from January 1, 2019 to May 31, 2020 were enrolled. Read More

Ann Thorac Surg 2021 Jun 7. Epub 2021 Jun 7.

Department of Thoracic Surgery, IRCCS San Raffaele Scientific Institute, Milan, Italy; Faculty of Medicine and Surgery, Vita-Salute San Raffaele University, Milan, Italy. Electronic address:

Cardiovascular comorbidities often prevent patients with otherwise resectable early-stage lung cancer from undergoing surgery due to prohibitive peri-operative risk. Here we describe the first intraoperative use of venoarterial (VA) ECMO in a stage cIIA lung cancer patient with arterial infiltration and severe post-ischemic dilated cardiomyopathy (EF 23%) undergoing left upper lobectomy with pulmonary artery angioplasty. Providing intra-operative cardiovascular and respiratory function support, VA-ECMO represents a suitable option for patients with heart failure, ensuring adequate hemodynamic profile and reducing the risk of complications. Read More

Ann Pharmacother 2021 Jun 10:10600280211021103. Epub 2021 Jun 10.

Largo Medical Center, Largo, FL, USA.

Background: Multiple publications demonstrate an association between time to initiation of corticosteroids and outcomes such as mortality and reversal of shock. However, the optimal time to initiate hydrocortisone remains unknown.

Objective: To evaluate the impact of early versus late initiation of hydrocortisone in septic shock patients. Read More

Biocybern Biomed Eng 2021 Jun 5. Epub 2021 Jun 5.

Department of Computer Science, University of Saskatchewan, Canada.

The newly identified Coronavirus pneumonia, subsequently termed COVID-19, is highly transmittable and pathogenic with no clinically approved antiviral drug or vaccine available for treatment. The most common symptoms of COVID-19 are dry cough, sore throat, and fever. Symptoms can progress to a severe form of pneumonia with critical complications, including septic shock, pulmonary edema, acute respiratory distress syndrome and multi-organ failure. Read More

In Vitro Cell Dev Biol Anim 2021 Jun 9. Epub 2021 Jun 9.

Department of Intensive Care Unit, Taizhou First People's Hospital, No. 218 Hengjie Road, Huangyan District, Taizhou City, 318020, Zhejiang Province, China.

Septic shock leads to myocardial dysfunction and induces inflammation. Nod-like receptor family pyrin domain-containing 3 (NLRP3) inflammasomes are involved in inflammation, and gastrodin can inhibit the activity of inflammasomes. Our study aimed to explore the effect of gastrodin against septic shock-induced injury through inhibiting NLRP3. Read More

J Intensive Care Med 2021 Jun 9:8850666211024188. Epub 2021 Jun 9.

Department of Emergency Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.

Background: Despite thrombocytopenia, patients with sepsis often experience hypercoagulability. However, limited information is available on the prevalence and effect of hypercoagulability in patients with sepsis-induced thrombocytopenia. Hence, we evaluated the prevalence of hypercoagulability and the association between hypercoagulability and clinical outcomes in septic shock patients with thrombocytopenia. Read More

Am J Physiol Lung Cell Mol Physiol 2021 Jun 9. Epub 2021 Jun 9.

Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, grid.414179.eDuke University Medical Center, Durham, NC.

Background: Bacterial pneumonia is a major cause of morbidity and mortality worldwide despite the use of antibiotics, and novel therapies are urgently needed. Building on previous work, we aimed to 1) develop a baboon model of severe pneumococcal pneumonia and sepsis with organ dysfunction; and 2) test the safety and efficacy of a novel extracorporeal blood filter to remove pro-inflammatory molecules and improve organ function.

Methods: After a dose-finding pilot study, twelve animals were inoculated with S. Read More

J Spec Oper Med 2021 ;21(2):80-84

Although skin and soft tissue infections are common in the deployed setting, infectious myositis is relatively uncommon. Bacterial infection of the muscle is the most common infectious etiology and can result in a spectrum of disease, to include abscess formation to necrotizing myositis, toxic shock syndrome, and death. Diagnosis can be elusive, particularly in the early stages. Read More

Eur Heart J Case Rep 2021 Feb 8;5(2):ytab013. Epub 2021 Feb 8.

Department of Cardiology, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London, W12 0HS, UK.

Background: Coronavirus disease 2019 (COVID-19) myocarditis is emerging as a component of the hyperactive inflammatory response secondary to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Isolated gastrointestinal symptoms are uncommon presenting features in adults with COVID-19 myocarditis. The availability of antibody testing is a valuable addition to the confirmation of COVID-19, when repeated reverse transcriptase-polymerase chain reaction of nasopharyngeal swabs are negative. Read More

Glob Pediatr Health 2021 31;8:2333794X211022711. Epub 2021 May 31.

Phramongkutklao Hospital and College of Medicine, Bangkok, Thailand.

Early recognition and management are the key elements to prevent febrile neutropenia associated mortality. The prospective observational study aimed to investigate prognostic accuracy of serum lactate to predict septic shock within 48 hours among hemodynamically stable children with febrile neutropenia. In all, 99 pediatric oncology patients who developed febrile neutropenia were enrolled in the study. Read More

Infect Drug Resist 2021 31;14:1989-2001. Epub 2021 May 31.

Department of Medicine, Saint Vincent Hospital, Worcester, MA, 01608, USA.

Introduction: is an aerobic gram-negative rod predominantly found in soil and aquatic environments. The typical reservoirs of spp. include the gastrointestinal tract and the upper respiratory tract. Read More

Pediatr Neonatol 2021 May 14. Epub 2021 May 14.

Department of Hematology/Oncology, Children's Hospital of Fudan University, 399 Wan Yuan Road, Shanghai, China; Hospital Administration, National Children's Medical Center, Children's Hospital of Fudan University, 399 Wan Yuan Road, Shanghai, China. Electronic address:

Background: The incidence and mortality of influenza in children had risen, but data are limited on children with severe influenza virus infection in China.

Methods: We conducted a retrospective case-control study and collected the patients' clinical data. Clinical data including demography, clinical presentation, laboratory findings, radiologic findings, treatment and outcomes were collected. Read More

Eur J Intern Med 2021 Jun 5. Epub 2021 Jun 5.

Unit of Cell Biology, Biotechnology of Animal and Human Reproduction (TechnoSperm), Department of Biology, Faculty of Medicine, Institute of Food and Agricultural Technology, University of Girona, C/ Emili Grahit, 77, 17071 Girona, Spain. Electronic address:

BMC Neurol 2021 Jun 8;21(1):217. Epub 2021 Jun 8.

Department of Neurology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, 371-8511, Gunma, Japan.

Background: Lacosamide (LCM) is the antiepileptic drug approved by the U.S. Food and Drug Administration in 2008 that facilitates slow activation of the voltage-gated sodium channels. Read More

Zhonghua Er Ke Za Zhi 2021 Jun;59(6):489-494

Department of Neonatal Intensive Care, Xi'an Children's Hospital, Xi'an Jiao Tong University, Xi'an 710003, China.

To investigate the predictive value of lactate concentration within 1 h after admission combined with lactate clearance rate (LC) at 6 h after fluid resuscitation in prognosis of neonatal septic shock. In this retrospective study, 58 newborns with septic shock admitted to the Neonatal Intensive Care Unit of Xi'an Children's Hospital,Xi'an Jiao Tong University from June 2016 to March 2020 were enrolled. According to the mortality within 60 days after admission,which was also set as the end point, the patients were divided into death group and survival group. Read More

Minerva Anestesiol 2021 Jun 8. Epub 2021 Jun 8.

Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Background: Leptin, the prototype adipokine, exerts immunomodulatory actions being implicated in inflammatory responses during sepsis. Clinical evidence regarding its role in sepsis has been contradictory, while free leptin has not been studied. Our aim was to jointly investigate circulating total leptin, its soluble receptor (sOBR), and free leptin, as well as their kinetics in critically ill patients with sepsis regarding their diagnostic and prognostic value. Read More

PLoS One 2021 8;16(6):e0252955. Epub 2021 Jun 8.

Department of Emergency and Critical Care Medicine, Tohoku University Hospital, Sendai, Japan.

Background: The distribution of body mass in populations of Western countries differs from that of populations of East Asian countries. In East Asian countries, fewer people have a high body mass index than those in Western countries. In Japan, the country with the highest number of older adults worldwide, many people have a low body mass index. Read More

Pediatr Crit Care Med 2021 Jun 8. Epub 2021 Jun 8.

Division of Pediatric Critical Care Medicine, Department of Pediatrics, CHU Sainte-Justine, Université de Montréal, Montréal, QC, Canada. CHU Sainte-Justine Research Center, Montréal, QC, Canada. Department of Psychology, Université de Montréal, Montréal, QC, Canada.

Objectives: Hospitalization in a PICU is a life-altering experience for children and their families. Yet, little is known about the well-being of these children after their discharge. We are describing the outcome of PICU survivors at a PICU clinic 2 months after discharge. Read More

Surg Case Rep 2021 Jun 8;7(1):137. Epub 2021 Jun 8.

Department of Surgery, Itami City Hospital, 1-100 Koyaike, Itami-shi, Hyogo, 664-8540, Japan.

Background: Clostridioides (Clostridium) difficile infection (CDI) has become an increasingly significant disease not only as healthcare-associated infection, but also as community-acquired (CA) infection worldwide. CDI caused by the NAP1/BI/027 strain is reported to be more severe, difficult to cure, and frequently associated with recurrences in North America and Europe.

Case Presentation: A 68-year-old woman was referred to our hospital for continuous lower abdominal pain 4 weeks after eradication therapy against Helicobacter pylori. Read More

Chest 2021 Jun;159(6):e377-e380

Department of Internal Medicine, Pulmonary, and Critical Care, University of Michigan, Ann Arbor, MI.

Case Presentation: An 80-year old man presented to the ED after being found down in his home. He had gone to the restroom to perform straight catheterization, as he normally does for his enlarged prostate, and was found slumped over and confused. On arrival to the ED, he was found to be in atrial fibrillation with rapid ventricular response, febrile, and hypotensive. Read More

Zhonghua Yi Xue Za Zhi 2021 Jun;101(21):1572-1582

Department of Laboratory Medicine, Peking University People's Hospital, Beijing 100044, China.

To explore the risk factors for carbapenem-resistant (CRE) infection and death. A case-control analysis of 482 inpatients in 18 secondary or tertiary hospitals in Beijing in 2018 was conducted. Patients infected by CRE were selected as the case group (247), and infected by carbapenem susceptible (CSE) as the control group (235). Read More