Search Our Scientific Publications & Authors

Int J Antimicrob Agents 2020 Jul 3:106075. Epub 2020 Jul 3.

Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Infectious Diseases Unit. Hospital Universitario Reina Sofía, Universidad de Cordoba, Cordoba, Spain.

Background: Infections caused by KPC-producing K. pneumoniae (KPC-Kp) are not well represented in pivotal trials with ceftazidime-avibactam (CAZ-AVI). Our aim was to investigate its efficacy in a single-centre cohort of patients infected with KPC-Kp. Read More

J Histochem Cytochem 2020 Jul 6:22155420937087. Epub 2020 Jul 6.

Department of Pathology, O'Neal Comprehensive Cancer Center.

Both heparanase and syndecan-1 are known to be present and active in disease pathobiology. An important feature of syndecan-1 related to its role in pathologies is that it can be shed from the surface of cells as an intact ectodomain composed of the extracellular core protein and attached heparan sulfate and chondroitin sulfate chains. Shed syndecan-1 remains functional and impacts cell behavior both locally and distally from its cell of origin. Read More

Eur J Clin Microbiol Infect Dis 2020 Jul 4. Epub 2020 Jul 4.

Regeneron Pharmaceuticals, Inc, Tarrytown, NY, USA.

The complement system is a vital component of the innate immune system, though its role in bacteremia is poorly understood. We present complement levels in Staphylococcus aureus bacteremia (SAB) and Gram-negative bacteremia (GNB) and describe observed associations of complement levels with clinical outcomes. Complement and cytokine levels were measured in serum samples from 20 hospitalized patients with SAB, 20 hospitalized patients with GNB, 10 non-infected hospitalized patients, and 10 community controls. Read More

Home Healthc Now 2020 Jul/Aug;38(4):188-192

Marijke Vroomen Durning, RN, is Director of Content, Sepsis Alliance, San Diego, California.

Sepsis is a life-threatening response to infection that affects over 1.7 million people annually in the United States. Although sepsis can strike healthy and active people of all ages, those at highest risk are older adults, infants, and people with chronic illnesses or an impaired immune system. Read More

Cardiol Young 2020 Jun 18:1-8. Epub 2020 Jun 18.

Department of Cardiovascular Surgery, Istanbul Medipol University Medical Faculty, Istanbul, Turkey.

Aim: Standard surgical treatment of the interrupted aortic arch with the use of cardiopulmonary bypass is risky especially in critically ill babies. In this manuscript, we present the results of off-pump pericardial roll bypass for the treatment of aortic interruption.

Material And Methods: The technique was applied in nine critically ill infants between July 2011 and December 2019. Read More

Intern Med J 2020 Jul 2. Epub 2020 Jul 2.

Department of Critical Care Medicine, Division of Anesthesiology and Critical Care, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit #112, Houston, Texas, 77030, USA.

Objective: Cardiac dysfunction is a common sequela in patients with sepsis and multi-organ dysfunction. Echocardiography is commonly used in the investigation of circulatory failure. We aimed to evaluate the prognostic value of echocardiographic parameters in patients with septic shock. Read More

South Med J 2020 Jul;113(7):345-349

From the Division of Trauma & Surgical Critical Care and the Department of Research Administration, Jersey Shore University Medical Center, Neptune, New Jersey.

Objective: The purpose of the study was to evaluate whether early colectomy in patients who have toxic megacolon due to colitis reduces mortality.

Methods: The study was performed using the American College of Surgeons National Surgical Quality Improvement Program database from 2012 to 2016. All patients 18 to 89 years of age who underwent colectomy for toxic megacolon resulting from colitis were included in the study. Read More

Can J Hosp Pharm 2020 May-Jun;73(3):209-215. Epub 2020 Jun 1.

, BSc, BSc(Pharm), ACPR, is with the Department of Pharmacy Services and the Department of Emergency Medicine, Surrey Memorial Hospital, Surrey, British Columbia.

Background: Critically ill patients often need vasopressors to treat hypotension related to septic shock and to maintain adequate systemic perfusion. Although the 2017 guidelines of the Surviving Sepsis Campaign recommend norepinephrine as first-line therapy, they also state that vasopressin may be considered as an adjunctive agent for patients with refractory shock. Limited evidence is available for directing optimal administration of vasopressin. Read More

Sci Rep 2020 Jul 2;10(1):10891. Epub 2020 Jul 2.

Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Guldhedsgatan 10A, 413 46, Göteborg, Sweden.

Tofacitinib, a janus kinase inhibitor, is a novel immunosuppressive drug for treatment of rheumatoid arthritis (RA). Septic arthritis (SA) and sepsis caused by Staphylococcus aureus (S. aureus), for which RA patients are at risk, are infections with high mortality. Read More

Clin Infect Dis 2020 Jul 2. Epub 2020 Jul 2.

Centers for Disease Control and Prevention - Infectious Diseases Pathology Branch, Atlanta, Georgia, United States of America.

Background: Death in patients with chikungunya is rare, and has been associated with encephalitis, hemorrhage, and septic shock. We describe clinical, histologic and immunohistochemical findings in individuals who died following chikungunya virus (CHIKV) infection.

Methods: We identified individuals who died in Puerto Rico during 2014 following an acute illness, and had CHIKV RNA detected by RT-PCR in a pre- or post-mortem blood or tissue specimen. Read More

Can J Kidney Health Dis 2020 19;7:2054358120934215. Epub 2020 Jun 19.

Escola de Medicina, Pontifícia Universidade Católica do Paraná, Curitiba, Brazil.

Background: Acute kidney injury (AKI) is a common complication in critical care patients. The presence of AKI is a marker for poor outcomes such as longer hospitalization durations, more hospital readmissions, and especially, higher mortality rates. Sepsis is one of the major causes of AKI within the intensive care unit (ICU) population. Read More

New Microbes New Infect 2020 Jul 23;36:100698. Epub 2020 May 23.

108 Military Central Hospital, Ha Noi, Vietnam.

is rarely known to cause infections in humans. We report the first case of pneumonia and septic shock caused by in a 38-year-old man in Vietnam. may be an emerging infectious agent in humans. Read More

J Intensive Care 2020 30;8:44. Epub 2020 Jun 30.

Division of Acute and Critical Care Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan.

Background: Diagnosing sepsis remains difficult because it is not a single disease but a syndrome with various pathogen- and host factor-associated symptoms. Sepsis-3 was established to improve risk stratification among patients with infection based on organ failures, but it has been still controversial compared with previous definitions. Therefore, we aimed to describe characteristics of patients who met sepsis-2 (severe sepsis) and sepsis-3 definitions. Read More

Cancer Manag Res 2020 25;12:4969-4979. Epub 2020 Jun 25.

Department of Medical Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, People's Republic of China.

Background: Cancers of the gastrointestinal (GI) tract and its associated excretory glands are one of the most common causes of cancer-related death worldwide, and these patients are more likely to developing nosocomial infections due to immunodeficiency.

Objective: To explore the bacterial profile, antibiotic resistance pattern, and prognostic factors of nosocomial infections in hospitalized GI cancer patients.

Methods: All electronic medical records of nosocomial infection episodes in hospitalized GI cancer patients were retrospectively reviewed. Read More

Trials 2020 Jul 1;21(1):601. Epub 2020 Jul 1.

Department of Anaesthesiology, Critical Care Medicine and Burn Unit, AP-HP, Saint Louis and Lariboisière University Hospitals, 2 rue A. Paré, 75010, Paris, France.

Background: Septic shock remains a significant cause of death in critically ill patients. During septic shock, some patients will retain microcirculatory disorders despite optimal hemodynamic support (i.e. Read More

Acute Med 2019 ;18(1):56-58

Department of Anesthesia & Intensive Care Unit, SAMU, Hôpital Necker - Enfants Malades 149 rue de Sèvres 75015 Paris, University Paris Descartes, France.

To specify whether an association exists between pre-hospital body temperature collected by the emergency medical services (EMS) call centre, and intensive care unit (ICU) admission of patients with septic shock. An observational study based on data collected by the EMS of Paris. All septic shocks were included. Read More

Rev Bras Ter Intensiva 2020 Jun 24. Epub 2020 Jun 24.

Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul - Porto Alegre (RS), Brasil.

Objective: To assess the relationship between time to focus clearance and hospital mortality in patients with sepsis and septic shock.

Methods: This was an observational, single-center study with a retrospective analysis of the time to clearance of abdominal septic focus. Patients were classified according to the time to focus clearance into an early (≤ 12 hours) or delayed (> 12 hours) group. Read More

Crit Care 2020 Jun 30;24(1):387. Epub 2020 Jun 30.

Division of Acute and Critical Care Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan.

Background: Elderly patients have a blunted host response, which may influence vital signs and clinical outcomes of sepsis. This study was aimed to investigate whether the associations between the vital signs and mortality are different in elderly and non-elderly patients with sepsis.

Methods: This was a retrospective observational study. Read More

Shock 2020 Jun 25. Epub 2020 Jun 25.

Department of Critical Care Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.

Sepsis-induced myocardial dysfunction (SIMD) contributes significantly to cardiovascular dysfunction during septic shock. We aimed to evaluate the potential role of Xinmailong injection (XMLI), a polypeptide medicine extracted from Periplaneta americana, in reversing the progression of myocardial damage to SIMD in sepsis patients. This was a multicenter, randomized, double-blind, parallel-group trial. Read More

Int J Immunopathol Pharmacol 2020 Jan-Dec;34:2058738420936386

Department and Clinic of Anaesthesiology and Intensive Therapy, Wroclaw Medical University, Wroclaw, Poland.

Introduction: Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection. Mortality rates are high, exceeding 50% in patients with septic shock. The sepsis severity score (SSS) was developed to determine the severity of sepsis and as a prognostic model. Read More

Diabetes Metab J 2020 06 21;44(3):405-413. Epub 2020 May 21.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Yeungnam University Medical Center, Yeungnam University College of Medicine, Daegu, Korea.

Background: To determine the role of diabetes mellitus (DM) in the coronavirus disease 2019 (COVID-19), we explored the clinical characteristics of patients with DM and compared risk factors such as age, glycemic control, and medications to those without DM.

Methods: This was a retrospective cohort study of 117 confirmed patients with COVID-19 which conducted at a tertiary hospital in Daegu, South Korea. The primary outcome was defined as the severe and critical outcome (SCO), of which the composite outcomes of acute respiratory distress syndrome, septic shock, intensive care unit care, and 28-day mortality. Read More

Emerg Med Australas 2020 Jun 29. Epub 2020 Jun 29.

Emergency and Trauma Centre, Royal Brisbane and Women's Hospital, Herston, Queensland, Australia.

Objective: Early recognition and treatment for sepsis is critical in improving patient outcomes. The present study sought to examine whether triage location was associated with time to appropriate antibiotics in a cohort of ED patients with septic shock.

Methods: Septic shock patients were identified from a database of ED patients admitted with infection. Read More

Rev Infirm 2020 Apr - May;69(260-261):28-29

La Tourmaline, 31, boulevard Salvador-Allende, 44818 Saint-Herblain cedex, France. Electronic address:

The amputation of multiple limbs is a rare but serious consequence of septic shock. It concerns young and active populations. The aim of rehabilitation is to enable patients to regain their independence and former everyday life. Read More

Rev Infirm 2020 Apr - May;69(260-261):25-27

Association Ensemble coordonner et accompagner, 9-11, rue Guyton-de-Morveau, 75013 Paris, France. Electronic address:

Nurses can contribute to the decision-making process in emergency situations in cases of septic shock, particularly if the patient has not drawn up advance directives and/or nominated a health care proxy. They can undertake or facilitate the collective decision making on the legal and ethical level. The team's habitus in terms of ethical analysis and the gathering of initial data can help to ensure the patients wishes are respected. Read More

Rev Infirm 2020 Apr - May;69(260-261):22-24

Service de gériatrie, centre hospitalier universitaire Grenoble-Alpes, avenue Maquis-du-Grésivaudan, 38700 La Tronche, France.

As septic shock is a life-threatening condition, acting quickly is a crucial element of its treatment. Nurses must be equipped with the skills to be able to recognise the warning signs and notify the doctor quickly. Read More

Rev Infirm 2020 Apr - May;69(260-261):19-21

Service de réanimation, hôpital d'instruction des armées Clermont-Tonnerre, 22, rue du Colonel-Fonferrier, 29240 Brest, France. Electronic address:

The treatment of septic shock is a medical emergency. International guidelines advise immediate care and the first hour is generally critical. It is an emergency on both an etiological and symptomatic level. Read More

Rev Infirm 2020 Apr - May;69(260-261):16-18

Service de médecine intensive réanimation, hôpital Raymond-Poincaré, GHU, AP-HP université Paris-Saclay, 104, boulevard Raymond-Poincaré, 92380 Garches, France; UFR Simone-Veil Santé, université de Versailles - Saint-Quentin-en-Yvelines, université Paris-Saclay, 2, avenue de la Source-de-la-Bièvre, 78180 Montigny-le-Bretonneux, France. Electronic address:

Septic shock, defined as the combination of sepsis, a requirement for catecholamines to maintain systolic blood pressure above 65 mmHg and a serum lactate level above 2 mmol/L despite adequate volume resuscitation is a life-threatening condition. The Quick Sepsis-related Organ Failure Assessment (qSOFA), which can be used by all nurses with a high-risk patient presenting with infection, enables the patient to be transferred rapidly to specialist care units. Read More

Crit Care 2020 Jun 29;24(1):380. Epub 2020 Jun 29.

Department of Anesthesiology and Intensive Care Unit, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, 1665 Kongjiang Road, Shanghai, 200092, China.

Background: Platelets have been demonstrated to be potent activators of neutrophil extracellular trap (NET) formation during sepsis. However, the mediators and molecular pathways involved in human platelet-mediated NET generation remain poorly defined. Circulating plasma exosomes mostly originating from platelets may induce vascular apoptosis and myocardial dysfunction during sepsis; however, their role in NET formation remains unclear. Read More

Crit Care 2020 Jun 29;24(1):385. Epub 2020 Jun 29.

Division of Intensive Care Medicine, Department of Anesthesiology, Research Group of Surgery, Anesthesiology and Intensive Care Medicine, Oulu University Hospital, Medical Research Center Oulu, University of Oulu, Oulu, Finland.

Background: Neuroinflammation often develops in sepsis along with increasing permeability of the blood-brain barrier (BBB), which leads to septic encephalopathy. The barrier is formed by tight junction structures between the cerebral endothelial cells. We investigated the expression of tight junction proteins related to endothelial permeability in brain autopsy specimens in critically ill patients deceased with sepsis and analyzed the relationship of BBB damage with measures of systemic inflammation and systemic organ dysfunction. Read More

Cancers (Basel) 2020 Jun 24;12(6). Epub 2020 Jun 24.

Department of Intensive Care Medicine, University Medical Centre Hamburg-Eppendorf, 20246 Hamburg, Germany.

High dose chemotherapy (HDT) followed by autologous peripheral blood stem cell transplantation (ASCT) is standard of care including a curative treatment option for several cancers. While much is known about the management of patients with allogenic SCT at the intensive care unit (ICU), data regarding incidence, clinical impact, and outcome of critical illness following ASCT are less reported. This study included 256 patients with different cancer entities. Read More

Alcohol Alcohol 2020 Jun 30. Epub 2020 Jun 30.

Department of Emergency Medicine, E-Da Hospital, I-Shou University, No. 1, Yida Road, Jiaosu Village, Kaohsiung 82445, Taiwan.

Aims: Patients with liver cirrhosis are more susceptible to bacteremia and more likely to have a poor prognosis in comparison to healthy individuals. Studies on the role of alcohol in cirrhotic patients with bacteremia are limited. Our study aimed to investigate the clinical characteristics and prognostic differences between the patients with alcohol and non-alcohol-associated cirrhosis with bacteremia. Read More

J Pediatr Adolesc Gynecol 2020 Jun 26. Epub 2020 Jun 26.

Department of Obstetrics and Gynecology, Saitama Medical University, 38 Morohongo, Moroyama-machi, Iruma-gun, Saitama 350-0495, Japan.

Background: Infectious mononucleosis (IM) develops following primary infection with Epstein-Barr virus. We report a case of septic shock in an adolescent from pelvic inflammatory disease caused by Fusobacterium necrophorum following sexual intercourse during recovery from IM.

Case: A 17-year-old girl with a 7-day history of fever was diagnosed with IM. Read More

Ter Arkh 2019 Aug 15;91(8):84-92. Epub 2019 Aug 15.

National Research Center for Hematology.

Aim: To study the risk factors, symptoms and outcomes of candidemia caused by C. albicans and C. non - albicans in patients with hematological malignancies. Read More

Jt Comm J Qual Patient Saf 2020 Jul 19;46(7):381-391. Epub 2020 Apr 19.

Background: In recognition of the potential of data to drive care and the need for early identification of patients with sepsis, HCA Healthcare developed an automated sepsis detection algorithm-SPOT (Sepsis Prediction and Optimization of Therapy). The algorithm was deployed at scale and served as a mechanism to reduce the time to detection and improve sepsis mortality in 173 hospitals across the United States.

Methods: The SPOT algorithm was designed as a rules-based detection of defined criteria that would interpret available electronic and basic laboratory data in near real time. Read More

Surg Infect (Larchmt) 2020 Jun 26. Epub 2020 Jun 26.

Department of General Surgery, Hospital Universitario La Princesa, Madrid, Spain.

Carbapenemase-producing (CPE)-related infections are a problem in public health at present, including intra-abdominal infections (IAI) and surgical populations. The aim of this study was to determine mortality and related risk factors, length of stay (LOS,) and costs for CPE-IAI in surgical patients. Review of CPE-related IAI acquired during admission in a general surgery department from January 2013 to December 2018. Read More

In Silico Biol 2020 Jun 22. Epub 2020 Jun 22.

Université Claude Bernard Lyon 1, CNRS, LAGEPP UMR 5007, Villeurbanne, France.

A dynamical model of the pathophysiological behaviors of IL18 and IL10 cytokines with their receptors is tested against data for the case of early sepsis. The proposed approach considers the surroundings (organs and bone marrow) and the different subsystems (cells and cyctokines). The interactions between blood cells, cytokines and the surroundings are described via mass balances. Read More

IDCases 2020 18;21:e00876. Epub 2020 Jun 18.

Service d'Anesthésie et Réanimation, CH de Saintonge, 11, Boulevard Ambroise Paré, 17100, Saintes, France.

Although bacterial vaginosis is the most common and benign vaginal infection worldwide, some cases of severe acute infections have been described in the literature. We report the case of a 57-year-old French female who developed a life-threatening postoperative peritonitis after a total hysterectomy with adnexectomy in the context of the removal of leiomyosarcoma. The microbiological analysis of the peritoneal fluid identified and The final diagnosis was a septic shock induced by an early onset peritonitis caused by and . Read More

Cureus 2020 May 25;12(5):e8268. Epub 2020 May 25.

Anesthesiology, State University of New York Downstate Medical Center, Brooklyn, USA.

A 74-year-old male was admitted to the Intensive Care Unit (ICU) at State University of New York (SUNY) Downstate Medical Center following acute respiratory failure secondary to coronavirus disease 2019 (COVID-19) viral pneumonia. The patient had significant comorbidities, including a history of lung and esophageal cancer status-post resection, cerebrovascular accident with neurological deficits, diabetes mellitus, hypertension, and peripheral vascular disease. The patient was in septic shock and respiratory failure on admission requiring intubation and mechanical ventilation. Read More

SAGE Open Med Case Rep 2020 18;8:2050313X20933473. Epub 2020 Jun 18.

Division of Trauma and Surgical Critical Care, Louisiana State University Health Sciences Center, Shreveport, LA, USA.

The COVID-19 pandemic has brought about an urgent need for effective treatment, while conserving vital resources such as intensive care unit beds and ventilators. Antivirals, convalescent plasma, and biologics have been used with mixed results. The profound "cytokine storm" induced endotheliopathy and microthrombotic disease in patients with COVID-19 may lead to acute respiratory distress syndrome, sepsis, and multi-organ failure. Read More

J Atheroscler Thromb 2020 Jun 26. Epub 2020 Jun 26.

Center of Diabetes, Endocrine and Metabolism, Toho University Sakura Medical Center.

Arterial stiffness is recognized mainly as an indicator of arteriosclerosis and a predictor of cardiovascular events. Cardio-ankle vascular index (CAVI), which reflects arterial stiffness from the origin of the aorta to the ankle, was developed in 2004. An important feature of this index is the independency from blood pressure at the time of measurement. Read More

BMJ Case Rep 2020 Jun 28;13(6). Epub 2020 Jun 28.

Critical Care, Mayo Clinic Florida, Jacksonville, Florida, USA

Mortality remains high in septic shock with few new treatment options. Angiotensin II has been recently approved for use in septic shock due to promising results in the ATHOS-3 trial. However, patients with neutropenia were excluded in the trial. Read More

J Infect Chemother 2020 Jun 25. Epub 2020 Jun 25.

Clinical Laboratory, Hirosaki University Hospital, Hirosaki, Japan; Department of Clinical Laboratory Medicine, Hirosaki University Graduate School of Medicine, Hirosaki, Japan; Aomori Infection Control Netowork, Hirosaki, Japan. Electronic address:

Introduction: The aim of this study was to investigate procalcitonin levels according to the causative pathogens of bacteremia. The relationships between the clinical outcomes and procalcitonin levels were also studied.

Methods: From among 452 patients, 507 cases of positive blood culture were included in the present study. Read More

Blood Purif 2020 Jun 26:1-4. Epub 2020 Jun 26.

Department of Intensive Care Unit, Imam Khomeini Hospital, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Hemoperfusion (HP) was helpful to prevent the development and progression of acute respiratory distress syndrome (ARDS), acute kidney injury (AKI), liver failure, and septic shock by removing cytokines and other inflammatory mediators and ultimately preventing progression toward multiple organ failure. A 54-year-old man diagnosed with COVID-19 was hospitalized in the intensive care unit. The patient's O2 saturation was 80% using an oxygen mask, which was gradually declining. Read More

Ann Emerg Med 2020 Jun 24. Epub 2020 Jun 24.

Department of Emergency Medicine, Orlando Regional Medical Center, Orlando Health, Orlando, FL; Residency in Emergency Medicine, Orlando Health, Orlando, FL.

Study Objective: Debate exists about the mortality benefit of administering antibiotics within either 1 or 3 hours of sepsis onset. We performed this meta-analysis to analyze the effect of immediate (0 to 1 hour after onset) versus early (1 to 3 hours after onset) antibiotics on mortality in patients with severe sepsis or septic shock.

Methods: This review was consistent with the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines. Read More

Therapie 2020 Jun 13. Epub 2020 Jun 13.

Pediatric intensive care unit, Necker hospital, 75015 Paris, France.

Aim Of The Study: Early administration of appropriate antibiotic therapy with adequate concentration is the cornerstone of the severe sepsis and septic shock's treatment. We aim to describe the plasma concentration of the most used β-lactams in critically ill children, to describe the rate of patients with suboptimal exposure, and associated clinical and biological factors.

Methods: From January 2016 to May 2017, children less than 18 years old with severe sepsis or septic shock were included. Read More

BMC Anesthesiol 2020 Jun 27;20(1):158. Epub 2020 Jun 27.

Department of Anesthesia and Intensive care, University Hospital of Foggia, Foggia, Italy.

Background: The control of endothelial progenitor cells (CD133+/CD34+ EPCs) migrating from bone marrow to peripheral blood is not completely understood. Emerging evidence suggests that stromal cell-derived factor-1α (SDF-1α) mediates egression of EPCs from bone marrow, while the hypoxia inducible factor (HIF) transcriptional system regulates SDF-1α expression. Our study aimed to investigate the time course of circulating CD133+/CD34+ EPCs and its correlation with the expression of HIF-1α protein and SDF-1α in postoperative laparoscopic abdominal septic patients. Read More

J Ethnopharmacol 2020 Jun 24:113068. Epub 2020 Jun 24.

Department of Emergency, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China. Electronic address:

Ethnopharmacological Relevance: Shenfu injection (SFI) is a well-known Chinese herbal medicine widely used in the treatment of septic shock in China.

Aims: The aims of this study are to investigate the protective effects of SFI on sepsis-induced myocardial injury in mice and to identify the underlying mechanism of action.

Materials And Methods: Seventy-two male C57/B6J mice (5-6 weeks old) were randomly divided into five groups: control (NC), sham sepsis (sham), sepsis (Lipopolysaccharide- LPS), sepsis treated with a low dose SFI, and sepsis treated with a high dose SFI. Read More

Am J Emerg Med 2020 Mar 25. Epub 2020 Mar 25.

Intensive Care Unit, Anesthesiology, SAMU, Necker Enfants Malades Hospital, Assistance Publique - Hôpitaux de Paris, Paris, France.

Context: In the prehospital setting, early identification of septic shock (SS) with high risk of poor outcome is a daily issue. There is a need for a simple tool aiming to early assess outcome in order to decide delivery unit (emergency department (ED) or intensive care unit (ICU)). In France, prehospital emergencies are managed by the Service d'Aide Médicale d'Urgence (SAMU). Read More

Medicine (Baltimore) 2020 Jun;99(26):e20914

Department of Respiratory Medicine.

Rationale: Methicillin-resistant Staphylococcus aureus (MRSA) has been established as an important cause of severe community-acquired pneumonia (CAP) with very high mortality. Panton-Valentine leukocidin (PVL) producing MRSA has been reported to be associated with necrotizing pneumonia and worse outcome. The incidence of community-acquired MRSA (CA-MRSA) pneumonia is very low, as only a few CA-MRSA pneumonia cases were reported in the last few years. Read More

Medicine (Baltimore) 2020 Jun;99(26):e20874

Department of Orthopaedics, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, Zhejiang Province.

Introduction: Idiopathic necrotizing fasciitis (NF) is an infrequent, highly lethal skin infection that spreads rapidly, marked by fascia and subcutaneous tissue necrosis. It occurs in the absence of a known causative factor. Its emergence after sterile orthopedic fixation with unexpected spread to the abdomen may turn to be challenging both as a medical and surgical emergency. Read More