229,595 results match your criteria Shock Septic
J Crit Care 2018 Dec 8;50:201-206. Epub 2018 Dec 8.
Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, United States; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN, United States.
Background: The association of pulmonary hypertension (PH) in patients with sepsis is lesser understood.
Methods: This was a retrospective study of adult patients admitted to the intensive care unit during 2007-2014 for sepsis and septic shock, with echocardiography performed <72 h. PH was defined as tricuspid regurgitation peak velocity (TRV) > 3 m/s on Doppler echocardiography. Read More
J Crit Care 2018 Dec 8;50:188-194. Epub 2018 Dec 8.
Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, Emory University, Atlanta, GA, United States.
Introduction: Despite international guidelines, regional differences in treatment of vasodilatory shock remain. We characterized these differences using data from Angiotensin II in High Output Shock (ATHOS-3) trial.
Methods: The 321 patients treated in the ATHOS-3 trial were included. Read More
Microb Pathog 2018 Dec 13. Epub 2018 Dec 13.
Department of Microbiology, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address:
Background: Bacterial superantigens are potent T cell activators that can have acute or chronic effects on the central nervous system.
Objectives: In this study, the role of enterotoxins, exfoliative toxins and toxic shock syndrome toxin of Staphylococcus aureus was investigated in MS patients and healthy nasal carriers.
Methods: Three-hundred fifty nasal swabs were collected from healthy nasal carriers (n = 210) and MS (n = 140) patients. Read More
Pharmacol Res 2018 Dec 13. Epub 2018 Dec 13.
Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, 410008, China; National Clinical Research Center for Geriatric Disorders (XIANGYA), Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China. Electronic address:
Stress response refers to the systemic nonspecific response upon exposure to strong stimulation or chronic stress, such as severe trauma, shock, infection, burn, major surgery or improper environment, which disturb organisms and damage their physical and psychological health. However, the pathogenesis of stress induced disorder remains complicated and diverse under different stress exposure. Recently, studies have revealed a specific role of microRNAs (miRNAs) in regulating cellular function under different types of stress, suggesting a significant role in the treatment and prevention of stress-related diseases, such as stress ulcer, posttraumatic stress disorder, stress-induced cardiomyopathy and so on. Read More
Ann Thorac Surg 2018 Dec 13. Epub 2018 Dec 13.
HealthTrust Purchasing Group, L.P.
Background: The study reports the impact of adverse events during the index CABG surgery on Medicare reimbursement for the index hospitalization and a 90-day follow-up period.
Methods: This retrospective study used 2014 Medicare claims files for hospitals, skilled nursing services, rehabilitation facilities, long-term care facilities, home health services and outpatient visits. The study sample is 37,106 Medicare beneficiaries that survived an index CABG in a US hospital during the first three quarters of 2014. Read More
Trends Cardiovasc Med 2018 Dec 6. Epub 2018 Dec 6.
John Ochsner Heart and Vascular Institute, Ochsner Medical Center, 1514 Jefferson Highway New Orleans, LA 70121, United States; Ochsner Clinical School, University of Queensland School of Medicine, New Orleans, LA, United States. Electronic address:
Rev Port Cardiol 2018 Dec 12. Epub 2018 Dec 12.
Servicio de Cardiología y Unidad Coronaria, Complexo Hospitalario Universitario de Santiago de Compostela; CIBERCV, A Coruña, Spain.
Biochem Biophys Res Commun 2018 Dec 12. Epub 2018 Dec 12.
Department of Forensic Medicine, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China. Electronic address:
Immune responses against antigens generally require an efficient activation of antigen-presenting cells (APCs). Currently, the targeting of vaccine antigens to APCs has emerged as a promising strategy for boosting vaccine immunogenicity. Here, we reported that the C-terminus of heat shock protein 60 (HSP60C) can activate mouse peritoneal macrophages to secret a series of cytokines, and phosphorylation of p38 mitogen-activated protein kinase (MAPK) and NF-κB p65 was involved in the pathway. Read More
J Chem Phys 2018 Dec;149(22):224703
CEA/DAM/DIF, F-91297 Arpajon, France.
The nanostructuration of energetic materials results in interesting properties. In particular, the detonation of carbon-rich explosives leads to the formation of nanodiamonds, the size of which is linked to the initial size of the explosive nanograins. This correlation could come from the role played by the granularity in the shock properties, especially the local temperature, which could be enhanced when the shock front crosses the various interfaces and nanoporosities of the material. Read More
Gastroenterology 2018 Dec 12. Epub 2018 Dec 12.
Unit of Internal Medicine and Hepatology (UIMH), Department of Medicine - DIMED, University of Padova, Padova, Italy. Electronic address:
Background And Aims: Bacterial infections are common and life-threatening in patients with cirrhosis. Little is known about the epidemiology of bacterial infections in different regions. We performed a multicenter prospective intercontinental study to assess the prevalence and outcomes of bacterial and fungal infections in patients with cirrhosis. Read More
J Gastroenterol Hepatol 2018 Dec 14. Epub 2018 Dec 14.
Department of Gastroenterology, The Second Military Medical University, Shanghai, China.
Background & Aims: Pancreatic extracorporeal shock wave lithotripsy (P-ESWL) is first-line treatment for chronic pancreatitis (CP) patients with pancreatic stones. However, the performance of P-EWSL in geriatric patients remains unclear. We aimed to evaluate the safety and efficacy of P-ESWL for them. Read More
Parasitol Res 2018 Dec 15. Epub 2018 Dec 15.
Departamento de Biología Celular, Cinvestav-IPN, Av. IPN 2508, Col. San Pedro Zacatenco, 07360, Ciudad de México, Mexico.
Transcription factor IID (TFIID) is a cornerstone in the transcription initiation in eukaryotes. It is composed of TBP and approximately 14 different subunits named TBP-associated factors (TAFs). TFIID has a key role in transcription of many genes involved in cell proliferation, cell growth, cell cycle, cell cycle checkpoint, and various other processes as well. Read More
Eur J Trauma Emerg Surg 2018 Dec 14. Epub 2018 Dec 14.
Department for Anesthesiology, Intensive Care Medicine, Emergency Medicine and Pain Therapy, Armed Forces Hospital Ulm, HEMS "Christoph 22", Oberer Eselsberg 40, 89081, Ulm, Germany.
Background: The TraumaRegister DGU (TR-DGU) of the German Trauma Society (Deutsche Gesellschaft für Unfallchirurgie, DGU) enables the participating hospitals to perform quality management. For that purpose, nine so-called audit filters have existed, since its foundation, which, inter alia, is listed in the Annual Report. The objective of this study effort is a revision of these quality indicators with the aim of developing pertinent new and reliable quality indicators for the management of severely injured patients. Read More
Biochem Biophys Res Commun 2018 Dec 11. Epub 2018 Dec 11.
Laboratory of Structural Biochemistry of Proteins, Bach Institute of Biochemistry, Federal Research Centre "Fundamentals of Biotechnology" of the Russian Academy of Sciences, Leninsky pr. 33, Moscow, 119071, Russia.
Small heat shock proteins (sHsps) are molecular chaperones preventing protein aggregation. Dynamics of quaternary structure plays an important role in the chaperone-like activity of sHsps. However, an interrelation between the oligomeric state and chaperone-like activity of sHsps remains insufficiently characterized. Read More
Genes (Basel) 2018 Dec 13;9(12). Epub 2018 Dec 13.
Faculty of Biology, Technion-Israel Institute of Technology, Technion City, Haifa 32000, Israel.
Adenosine to inosine (A-to-I) RNA editing is a highly conserved regulatory process carried out by adenosine-deaminases (ADARs) on double-stranded RNA (dsRNAs). Although a considerable fraction of the transcriptome is edited, the function of most editing sites is unknown. Previous studies indicate changes in A-to-I RNA editing frequencies following exposure to several stress types. Read More
Biomed Pharmacother 2019 Jan 6;109:484-492. Epub 2018 Nov 6.
Department of Pharmacology, Chitkara College of Pharmacy, Chitkara University, Rajpura, Punjab, India. Electronic address:
Cancer is an uncontrolled and abnormal growth of cells in the body. Gene that guards the cell cycle and function as tumor suppressor is p53 (also called as the guardian of the genome) which is encoded by the TP53 gene. Various events like DNA damage, heat shock, hypoxia and oncogene over expression, results in activation of p53. Read More
Biomaterials 2018 Dec 10;193:1-11. Epub 2018 Dec 10.
Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China; Department of Physics and Materials Science, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong, China. Electronic address:
Mild heat stimulation can promote the restoration of bone defects but unfortunately, the delivery of exo-hyperthermy into human body is not efficient enough. In this study, mild heat-induced osteogenesis with high efficacy is demonstrated on an osteoimplant composed of black phosphorus nanosheets and poly(lactic-co-glycolic acid) (BPs@PLGA) with the participation of near-infrared (NIR) light irradiation. BPs@PLGA with only 0. Read More
Res Vet Sci 2018 Nov 30;122:193-199. Epub 2018 Nov 30.
Department of Animal Wealth Development, Zagazig University, Sharkia, Egypt. Electronic address:
The aim was to elucidate the effects of strain and the duration of thermal stress (36 °C) on the carcass yield, metabolic hormones, immunological parameters and the relative expression of liver heat shock protein 90 (HSP90) and Myogenin genes. Two hundred and seventy day-old chicks (135 of each breed; Ross 308 and Cobb 500) were used in this trial. The birds were divided into 3 equal groups (CON: thermoneutral condition; S and S groups were subjected to 4 and 6 h of daily thermal stress, respectively. Read More
Virus Res 2018 Dec 11. Epub 2018 Dec 11.
VIDO-InterVac, University of Saskatchewan, Saskatoon, SK, S7N 5E3, Canada; Vaccinology & Immunotherapeutics, University of Saskatchewan, Saskatoon, SK, S7N 5E3, Canada; Microbiology & Immunology, University of Saskatchewan, Saskatoon, SK, S7N 5E3, Canada. Electronic address:
The U47 gene product, VP8, is a major tegument protein of BoHV-1. While VP8 is not essential for virus replication in cell culture, a U47-deleted virus exhibits a smaller tegument structure and is avirulent in cattle. To obtain pure VP8 protein for structural analysis, we expressed a N-terminally truncated version of VP8 in Eschericia coli. Read More
J Biomed Mater Res B Appl Biomater 2018 Dec 14. Epub 2018 Dec 14.
Department of Mechanical Engineering, University of Akron, Akron, Ohio, 44325.
Nickel-titanium (NiTi) alloy is an attractive material for biomedical implant applications. In this study, the effects of laser shock peening (LSP) on the biocompatibility, corrosion resistance, ion release rate and hardness of NiTi were characterized. The cell culture study indicated that the LSP-treated NiTi samples had lower cytotoxicity and higher cell survival rate than the untreated samples. Read More
Shock 2019 Jan;51(1):1-3
Department of Biological Sciences, University of North Carolina at Charlotte, Charlotte, North Carolina.
Trop Med Int Health 2018 Dec 14. Epub 2018 Dec 14.
Departamento de Microbiologia e Imunologia, Instituto de Biociências de Botucatu, Univ Estadual Paulista, Botucatu, Brazil.
Objective: To evaluate the molecular epidemiology and to georeference Staphylococcus aureus isolated from wounds and nares of patients seen at Basic Health Units (BHUs) of a Brazilian city.
Methods: Observational, cross-sectional study conducted from 2010 to 2013. A total of 119 S. Read More
Andrology 2018 Dec 13. Epub 2018 Dec 13.
Priority Research Centre for Reproductive Science, University of Newcastle, Callaghan, NSW, Australia.
Background And Objectives: Serine proteases are emerging as important players in the spermatozoon's acquisition of functional competence. This study aimed to characterize the serine protease testisin (PRSS21) in stallion spermatozoa, examining its surface expression, possible origins in the testis and epididymis, and changes in response to capacitation and acrosome reaction, as well as its capacity to form high molecular weight complexes and interact with other proteins.
Materials And Methods: The role of serine proteases in spontaneous capacitation and acrosome reaction of stallion spermatozoa was established using the serine protease inhibitor, AEBSF. Read More
Catheter Cardiovasc Interv 2018 Dec 13. Epub 2018 Dec 13.
St. John Hospital and Medical Center, Detroit, Michigan.
Successful cardiac catheterization procedure begins with safe vascular access and ends with effective hemostasis after equipment removal. These new and advanced technologies in the cath lab require large-bore arterial accesses. Large-bore sheaths are associated with blood flow obstruction resulting in limb ischemia. Read More
ChemMedChem 2018 Dec 13. Epub 2018 Dec 13.
University of Helsinki, Centre for Drug Research, Division of Pharmaceutical Biosciences, Viikinkaari 4, 00014, Helsinki, FINLAND.
Cellular chaperones that belong to the heat-shock protein 90 (Hsp90) family are a prerequisite for successful viral propagation for most viruses. The hepatitis C virus (HCV) uses Hsp90 for maturation, folding and modification of viral proteins. Based on our previous discovery that marine alkaloid analogues with 4,5,6,7-tetrahydrobenzo[1,2-d]thiazole-2-amine structure show inhibition of HCV replication and potential binding to Hsp90, a series of twelve novel compounds based on this scaffold was designed and synthesized. Read More
Transpl Infect Dis 2018 Dec 13:e13039. Epub 2018 Dec 13.
Department of Hematology, AZ Delta Roeselare.
Mucormycosis is an aggressive invasive fungal infection that occurs rarely in immunocompetent but frequently in immunocompromised patients. We present a case of a 68-year old patient with cutaneous mucormycosis due to Rhizopus pusillus. He was initially hospitalized for invasive pulmonary aspergillosis and diabetes mellitus secondary to acute graft-versus-host treatment with glucocorticoids after allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia. Read More
Echocardiography 2018 Dec 12. Epub 2018 Dec 12.
Mount Sinai West, Icahn School of Medicine at Mount Sinai, New York City, New York.
Background: Acute left ventricular (LV) apical ballooning with normal coronary angiography occurs rarely in obstructive hypertrophic cardiomyopathy (OHCM); it may be associated with severe hemodynamic instability.
Methods, Results: We searched for acute LV ballooning with apical hypokinesia/akinesia in databases of two HCM treatment programs. Diagnosis of OHCM was made by conventional criteria of LV hypertrophy in the absence of a clinical cause for hypertrophy and mitral-septal contact. Read More
ANZ J Surg 2018 Dec 11. Epub 2018 Dec 11.
Metro North Hospital and Health Service, Brisbane, Queensland, Australia.
Introduction: Injuries are a major cause of disability and lost productivity. The case for a national trauma registry has been recognized by the Australian Commission on Safety and Quality in Health Care and at a policy level.
Background: The need was flagged in 1993 by the Royal Australasian College of Surgeons and the Australasian Trauma Society. Read More
Transfusion 2018 Dec 11. Epub 2018 Dec 11.
Armed Service Blood Program, Brooke Army Medical Center, JBSA-Fort Sam Houston, Texas.
Background: Hemorrhage is the leading cause of preventable death in military and civilian traumatic injury. Blood product resuscitation improves survival. Low-titer Type O Whole Blood (LTOWB) was recently re-introduced to the combat theater as a universal resuscitation product for hemorrhagic shock. Read More
J Cell Mol Med 2018 Dec 8. Epub 2018 Dec 8.
Division of General Surgery, Department of Surgery, Taipei Medical University Hospital, Taipei, Taiwan.
Haemorrhagic shock and resuscitation (HS/R) may cause global ischaemia-reperfusion injury, which can result in systemic inflammation, multiorgan failure (particularly liver failure) and high mortality. Hinokitiol, a bioactive tropolone-related compound, exhibits antiplatelet and anti-inflammatory activities. Targeting inflammatory responses is a potential strategy for ameliorating hepatic injury during HS/R. Read More
Front Pediatr 2018 28;6:360. Epub 2018 Nov 28.
Centre National de Référence des Staphylocoques, Institut des Agents Infectieux, Centre de Biologie et de Pathologie Nord, Hospices Civils de Lyon, Lyon, France.
Toxic shock syndromes (TSS) are severe shocks due to staphylococcal or streptococcal infection that require specific treatments. The early recognition of these shocks is crucial to improve their outcomes. The primary objective of this study was to compare characteristics and outcomes of staphylococcal and streptococcal TSS in children, in order to identify putative early clinical diagnostic criteria. Read More
Sci Rep 2018 Dec 13;8(1):17813. Epub 2018 Dec 13.
Institute of Technological Sciences, Wuhan University, Wuhan, Hubei, 430072, China.
Electric corona discharge in a multi-phase system results in complex electro-hydrodynamic phenomena. We observed unconventional shock wave propagation on an oil thin film sprayed over a polymer-coated conductor. A hair-thin single shock wave arose when the high voltage bias of an overhung steel needle was abruptly removed. Read More
Proc Natl Acad Sci U S A 2018 Dec 13. Epub 2018 Dec 13.
Département de Biologie Cellulaire et Infection, Unité des Interactions Bactéries-Cellules, Institut Pasteur, F-75015 Paris, France;
To overcome the action of antibiotics, bacteria have evolved a variety of different strategies, such as drug modification, target mutation, and efflux pumps. Recently, we performed a genome-wide analysis of gene expression after growth in the presence of antibiotics, identifying genes that are up-regulated upon antibiotic treatment. One of them, , is a homolog of , which encodes a heat shock protein that rescues stalled ribosomes by separating their two subunits. Read More
Genes (Basel) 2018 Dec 12;9(12). Epub 2018 Dec 12.
Division of Evolutionary Biology, Faculty of Biology, LMU Munich, Grosshaderner Str. 2, 82152 Planegg-Martinsried, Germany.
Coping with daily and seasonal temperature fluctuations is a key adaptive process for species to colonize temperate regions all over the globe. Over the past 18,000 years, the tropical species Drosophila ananassae expanded its home range from tropical regions in Southeast Asia to more temperate regions. Phenotypic assays of chill coma recovery time (CCRT) together with previously published population genetic data suggest that only a small number of genes underlie improved cold hardiness in the cold-adapted populations. Read More
Int J Mol Sci 2018 Dec 12;19(12). Epub 2018 Dec 12.
College of Horticulture, Nanjing Agricultural University, Nanjing 210095, China.
Salinity is ubiquitous abiotic stress factor limiting viticulture productivity worldwide. However, the grapevine is vulnerable to salt stress, which severely affects growth and development of the vine. Hence, it is crucial to delve into the salt resistance mechanism and screen out salt-resistance prediction marker genes; we implicated RNA-sequence (RNA-seq) technology to compare the grapevine transcriptome profile to salt stress. Read More
Cells 2018 Dec 10;7(12). Epub 2018 Dec 10.
Cancer Research Center and Translational Laboratory, Department of Medical Research, Taipei Medical University Hospital, Taipei Medical University, Taipei 110, Taiwan.
The incidence of colorectal cancer (CRC) has significantly increased in recent decades, and this disease has become an important health issue worldwide. Currently, there is no useful prognostic or diagnostic biomarker for CRC. Heat shock protein 27 (HSP27) is a chaperone that interacts with many proteins. Read More
Materials (Basel) 2018 Dec 10;11(12). Epub 2018 Dec 10.
George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA.
As solder joints are being scaled down, intermetallic compounds (IMCs) are playing an increasingly critical role in the reliability of solder joints, and thereby an in-depth understanding of IMCs microstructure evolutions in micro-joints is of great significance. This study focused on coarsening behaviors of Ag₃Sn compounds in Sn-3.0Ag-0. Read More
Sensors (Basel) 2018 Dec 10;18(12). Epub 2018 Dec 10.
Department of Bioresource and Environmental Sciences, Kyoto Sangyo University, Kamigamo Motoyama Kitaku, Kyoto 603-8555, Japan.
Temperature is one of the most important environmental signals for plants. High and low temperatures have a variety of effects that affect plant growth and development profoundly. Further, temperature is an indication of seasonal change. Read More
J Fungi (Basel) 2018 Dec 7;4(4). Epub 2018 Dec 7.
Department of Microbiology, University of Tennessee, Knoxville, TN 37996, USA.
Strains of the bakers' yeast that are able to generate a multicellular structure called a mat on low percentage (0.3%) agar plates are given a selective advantage over strains that cannot exhibit this phenotype. This environment may exhibit some similarities to the rotting fruit on which often grows in nature. Read More
Medicine (Baltimore) 2018 Dec;97(49):e13582
Department of Critical Care Medicine, Suzhou Kowloon Hospital, Shanghai Jiao Tong University School of Medicine, Suzhou, China.
Rationale: The Epstein-Barr (EB) virus has rarely been reported as a cause of fulminant myocarditis. To our knowledge, the present case is the first report on myocardial calcification in EB viral myocarditis and rhabdomyolysis.
Patient Concerns: A 17-year-old man was admitted to the department with fever, chest tightness, and tachypnea that had been present for 2 days. Read More
Medicine (Baltimore) 2018 Dec;97(49):e13469
Department of Emergency Surgery, Union Hospital.
Rationale: About 50% of patients with a diagnosis of nonsmall cell lung carcinoma exhibit metastatic disease at the time of diagnosis. The preferential sites of extrapulmonary spread are the lymph nodes, liver, brain, adrenal glands, and bones; gastrointestinal tract perforation secondary to metastatic lung cancer is extremely rare.
Patient Concerns: A 60-year-old male nonsmoker patient presented with a 20-day history of facial, neck, and right upper limb edema. Read More
Nucleic Acids Res 2018 Dec 14. Epub 2018 Dec 14.
Université de Rennes 1, Inserm, BRM (Bacterial Regulatory RNAs and Medicine) UMR_S 1230, 35000 Rennes, France.
Bacterial type I toxin-antitoxin (TA) systems are widespread, and consist of a stable toxic peptide whose expression is monitored by a labile RNA antitoxin. We characterized Staphylococcus aureus SprA2/SprA2AS module, which shares nucleotide similarities with the SprA1/SprA1AS TA system. We demonstrated that SprA2/SprA2AS encodes a functional type I TA system, with the cis-encoded SprA2AS antitoxin acting in trans to prevent ribosomal loading onto SprA2 RNA. Read More
J Mol Graph Model 2018 Dec 4;87:144-164. Epub 2018 Dec 4.
Department of Pharmacology, Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria. Electronic address:
Plasmodium falciparum heat shock protein 90 (PfHsp90) has been investigated as a potential target of antimalarial drug action using naturally occurring compounds. In this study, we performed in silico screening of 236 phytochemicals of Azadirachta indica, a plant known to possess antimalarial activity, and identified fourteen (14) potential non-carcinogenic, non-mutagenic, non-teratogenic and non-genotoxic phytochemicals. These phytochemicals were docked into the ATP-binding site of PfHsp90 using Autodock vina, and docked poses were rescored using PLANTS ChemPlp, X-Score version 1. Read More
Int J Surg 2018 Dec 10;61:48-52. Epub 2018 Dec 10.
Department of Plastic Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taiwan. Electronic address:
Background: A systolic blood pressure (SBP) lower than the heart rate (HR) could indicate a poor condition in trauma patients. In such scenarios, the reversed shock index (RSI) is < 1, as calculated by the SBP divided by the HR. This study aimed to clarify whether RSI could be used to identify high-risk adult patients with isolated traumatic brain injury (TBI). Read More
Neurosci Biobehav Rev 2018 Dec 10. Epub 2018 Dec 10.
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, 5510 Nathan Shock Drive, Suite 101, Baltimore, MD, USA.
Adherence to pain self-management strategies is associated with favorable psychobehavioral outcomes among individuals with chronic pain. Substantive adherence to treatments teaching these adaptive skills proves challenging, resulting in poor individual and societal outcomes. Evidence demonstrates motivation for behavior change as a key predictor of treatment adherence. Read More
Behav Brain Res 2018 Dec 10. Epub 2018 Dec 10.
Neuroscience Discovery Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, 46285, USA. Electronic address:
The 5-HT receptor is the most recently identified receptor subtype within a family of 5-HT receptors activated by the neurotransmitter serotonin. There has been significant interest in investigating the potential role of this receptor in psychiatric disorders including depression, anxiety, and schizophrenia. Behaviors of 5-HT +/+ (wild-type or WT) and 5-HT -/- (receptor knockout or KO) mice were compared across 10 different assays (7 for anxiety, 1 for depression, 2 for psychosis) to identify differences that could indicate clinical potential for 5-HT receptor antagonism. Read More
Am J Respir Cell Mol Biol 2018 Dec 13. Epub 2018 Dec 13.
Medical University of South Carolina, Medicine, Charleston, South Carolina, United States.
Idiopathic Pulmonary Fibrosis (IPF) pathogenesis has been postulated to involve a variety of mechanisms associated with the aging process, including loss of protein homeostasis (proteostasis). Heat shock proteins (Hsp) are cellular chaperones that serve a number of vital maintenance and repair functions, including the regulation of proteostasis. Previously published data have implicated Hsp70 in the development of pulmonary fibrosis in animal models. Read More
Curr Cardiol Rev 2018 Dec 12. Epub 2018 Dec 12.
Department of Cardiology Bluhm Cardiovascular Institute Feinberg School of Medicine Northwestern University Medical Center, Chicago, Illinois, IL. United States.
The management of patients with shock is extremely challenging because of the myriad of possible clinical presentations in cardiogenic shock, septic shock and hypovolemic shock and the limitations of contemporary therapeutic options. The treatment of shock includes the administration of endogenous catecholamines (epinephrine, norepinephrine, and dopamine) as well as various vasopressor agents that have shown efficacy in the treatment of the various types of shock. In addition to the endogenous catecholamines, dobutamine, isoproterenol, phenylephrine, and milrinone have served as the mainstays of shock therapy for several decades. Read More
Curr Mol Med 2018 Dec 12. Epub 2018 Dec 12.
Department of Pharmacology, Gifu University Graduate School of Medicine, Gifu. Japan.
Background: We have recently reported that epidermal growth factor (EGF) induces migration of osteoblast-like MC3T3-E1 cells through the activation of p44/p42 mitogen-activated protein (MAP) kinase, p38 MAP kinase, stress-activated protein kinase/ c-Jun N-terminal kinase (SAPK/JNK) and Akt. Furthermore, we demonstrated that heat shock protein 70 (HSP70) down-regulates the transforming growth factor-β-stimulated vascular endothelial growth factor synthesis via suppression of p38 MAP kinase in osteoblast-like MC3T3-E1 cells. However, the exact role of HSP70 underlying osteoblast migration is not fully elucidated. Read More