Search Our Scientific Publications & Authors

J Crit Care 2021 Apr 20;64:184-192. Epub 2021 Apr 20.

Department of Anesthesiology, Surgical Intensive Care, Emergency and Pain Medicine, Ruhr-University Bochum, Klinikum Herford, Herford, Germany.

Background And Purpose: Hemoadsorption with CytoSorb® offers a possible therapeutic approach in septic shock, but modes of application and dosing are still undetermined.

Materials And Methods: Data from surgical patients with septic shock, treated with hemoadsorption adjunctive to renal replacement therapy were analyzed retrospectively. The 28-day mortality was compared to predicted mortality. Read More

Am J Med Sci 2021 May 4. Epub 2021 May 4.

Department of Critical Care Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing, China. Electronic address:

The gastrointestinal (GI) tract, especially the mucosa, is the most vulnerable organ to hypoperfusion among the splanchnic organs. Disturbed perfusion of the mesenteric area may lead to GI dysfunction, cause further injury to the patients and even vital outcomes. However, due to the limitation of detection methods, the hemodynamic influences on mesenteric blood flow in clinical practice are not fully understood. Read More

Photobiomodul Photomed Laser Surg 2021 May 9;39(5):349-354. Epub 2020 Dec 9.

State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, P.R. China.

This study aimed to compare the efficacy of conventional needle irrigation (CI), ultrasonically activated irrigation (UAI), photon-induced photoacoustic streaming (PIPS), and shock wave-enhanced emission photoacoustic streaming (SWEEPS) in removing calcium hydroxide [Ca(OH)] from root canals of mandibular molars using microcomputed tomography. Various adjunctive irrigation strategies have been recommended to improve the removal of Ca(OH). No reports have evaluated the SWEEPS laser-activated method for the removal of Ca(OH) from root canals of mandibular molars. Read More

Dimens Crit Care Nurs 2021 Mar-Apr 01;40(2):75-82

Background: Severe acute respiratory syndrome coronavirus 2 is the virus that causes coronavirus disease 2019 (COVID-19). COVID-19 is a disease characterized by a range of clinical syndromes including variable degrees of respiratory symptoms from mild respiratory illness and severe interstitial pneumonia to acute respiratory distress syndrome, septic shock, coagulopathies, and multiorgan dysfunction. This virus carries the potential to manifest in a wide range of pulmonary findings and hypoxemias, from mild respiratory symptoms to more severe syndromes, such as acute respiratory distress syndrome. Read More

Cogn Res Princ Implic 2021 May 7;6(1):36. Epub 2021 May 7.

School of Psychology, UNSW Sydney, Sydney, NSW, 2052, Australia.

People often need to update representations of information upon discovering them to be incorrect, a process that can be interrupted by competing cognitive demands. Because anxiety and stress can impair cognitive performance, we tested whether looming threat can similarly interfere with the process of updating representations of a statement's truthfulness. On each trial, participants saw a face paired with a personality descriptor. Read More

Curr Cardiol Rep 2021 May 7;23(6):66. Epub 2021 May 7.

Cardiology Division, Department of Medicine, University Hospital of Geneva, Geneva, Switzerland.

Purpose Of Review: Controversy exists whether beta-blockers should be given before primary percutaneous coronary intervention (PCI) or to defer their administration for up to 24 hours.

Recent Findings: Animal studies, most of them conducted in the 1970s and 1980s, showed evidence that early beta-blocker administration may reduce infarct size. Subsequent human studies had mixed results on infarct size and survival. Read More

G Ital Cardiol (Rome) 2021 May;22(5):404-423

U.O.C. Cardiologia, Ospedale Garibaldi-Nesima, Azienda di Rilievo Nazionale e Alta Specializzazione "Garibaldi", Catania - Fondazione per il Tuo cuore - Heart Care Foundation, Firenze.

The treatment of patients with advanced acute heart failure is still challenging. Intra-aortic balloon pump (IABP) has widely been used in the management of patients with cardiogenic shock. However, according to international guidelines, its routinary use in patients with cardiogenic shock is not recommended. Read More

Public Health Rep 2021 May 7:333549211013460. Epub 2021 May 7.

1242 Respiratory Diseases Branch, National Center for Immunizations and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.

Objectives: Routine surveillance for streptococcal toxic shock syndrome (STSS), a severe manifestation of invasive group A (GAS) infections, likely underestimates its true incidence. The objective of our study was to evaluate routine identification of STSS in a national surveillance system for invasive GAS infections.

Methods: Active Bacterial Core surveillance (ABCs) conducts active population-based surveillance for invasive GAS disease in selected US counties in 10 states. Read More

Andrology 2021 May 7. Epub 2021 May 7.

Institute of Urology, Lanzhou University Second Hospital, Key Laboratory of Urological Diseases, Gansu Province (Lanzhou University), Gansu Nephro-Urological Clinical Center, Lanzhou, China.

Background: Due to limited data on the pathogenesis of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) and the suboptimal therapeutic effect, the development of new and effective treatment modalities was needed urgently. Low-intensity extracorporeal shock wave therapy (Li-ESWT) has been reported for the treatment of CP/CPPS. However, the underlying mechanism remains to be elucidated. Read More

IUBMB Life 2021 May 7. Epub 2021 May 7.

Department of Pathology, Duke University Medical Center, Durham, North Carolina.

The 78 kDa glucose-regulated protein (GRP78) is an endoplasmic reticulum (ER)-resident molecular chaperone. GRP78 is a member of the 70 kDa heat shock family of proteins involved in correcting and clearing misfolded proteins in the ER. In response to cellular stress, GRP78 escapes from the ER and moves to the plasma membrane where it (i) functions as a receptor for many ligands, and (ii) behaves as an autoantigen for autoantibodies that contribute to human disease and cancer. Read More

J Card Surg 2021 May 7. Epub 2021 May 7.

Department of Cardiothoracic Surgery, Heart Centre Cologne, University Hospital Cologne, Cologne, Germany.

Objectives: Peripartum cardiomyopathy (PPCM) is a form of systolic heart failure occurring toward the end of pregnancy or in the period after delivery. Lack of myocardial recovery or therapy-refractory cardiogenic shock are rare complications and left ventricular assist device (LVAD) systems might be used as a life-saving option. The aim of this study was to investigate outcomes of PPCM patients supported with LVAD, registered in the European Registry for Patients with Mechanical Circulatory Support (EUROMACS). Read More

Metallomics 2021 May 7. Epub 2021 May 7.

School of Science, Western Sydney University, Locked Bag 1797, Penrith, NSW 2751, Australia.

A significant gap in the knowledge of zinc homeostasis exists for breast cancer cells. In this study, we investigated the transcriptomic response of the luminal breast cancer cells (MCF-7) to the exposure of extracellular zinc using next-generation RNA sequencing (RNA-seq). The dataset was collected for three time points (T0, T30 and T120) in the time course of zinc treatment, which revealed the dramatic increase, up to 869-fold, of the gene expression for metallothioneins (MT1B, MT1F, MT1X and MT2A) and the zinc exporter ZnT1 (SLC30A1) at T30, continuingly through to T120. Read More

Anatol J Cardiol 2021 May;25(5):355-359

Department of Cardiology, Walter Reed National Military Medical Center, Bethesda, MD.

Parasite Immunol 2021 May 7:e12842. Epub 2021 May 7.

Molecular Biology Research Center, School of Life Science, Central South University, 110 Xiangya Road, Changsha, Hunan, 410078, People' s Republic of China.

Aims: Schistosomiasis is a parasitic disease with a chronic debilitating character caused by parasitic flatworms of the genus Schistosoma. The main disease-causing species of Schistosoma in China is S. japonicum. Read More

CJEM 2021 May 18;23(3):314-324. Epub 2021 Jan 18.

Department of Emergency Medicine, University of Ottawa, Ottawa, ON, Canada.

Background: Acute atrial flutter has one-tenth the prevalence of acute atrial fibrillation in the emergency department (ED) but shares many management strategies. Our aim was to compare conversion from acute atrial flutter to sinus rhythm between pharmacological cardioversion followed by electrical cardioversion (Drug-Shock), and electrical cardioversion alone (Shock-Only).

Methods: We conducted a randomized, blinded, placebo-controlled comparison of attempted pharmacological cardioversion with IV procainamide followed by electrical cardioversion if necessary, and placebo infusion followed by electrical cardioversion. Read More

Adv Exp Med Biol 2021 ;1306:81-99

Tareev Clinic, Department of Nephrology, Sechenov First Moscow State Medical University, Moscow, Russia.

Chronic glomerulonephritis (CGN) is a disease with a steady progressive course that involves the development of nephrosclerosis, which is especially evident in clinical courses with incidences of high proteinuria (PU). Currently, proteinuria is considered the main laboratory feature (sign) of CGN activity and progression because proteinuria is closely related to the process of tubulointerstitial fibrosis, which is correlated with the grade of renal insufficiency. The injury to podocytes, which are key components of the filtration barrier, plays a central role in proteinuria development. Read More

Front Cardiovasc Med 2021 20;8:651496. Epub 2021 Apr 20.

Krannert Institute of Cardiology, Indiana University School of Medicine, Indianapolis, IN, United States.

Thirty four-year-old male with history of D-transposition of the great arteries (D-TGA) who underwent Mustard operation at 14 months of age presented in cardiogenic shock secondary to severe systemic right ventricular failure. Catheterization revealed significantly increased pulmonary pressures. Due to the patient's inotrope dependence and prohibitive pulmonary hypertension, he underwent implantation of a Heart Ware HVAD® for systemic RV support. Read More

Adv Biomed Res 2021 27;10. Epub 2021 Jan 27.

Nosocomial Infection Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: Methicillin-resistant (MRSA) has become a considerable public health concern in the entire world due to the rapid spread of this bacterium in human community; also the epidemiology of MRSA has changed, as the isolation of MRSA strains from healthy and non-healthy patients. Therefore, the objective of this study is to determine the genetic diversity and antibiotic resistance profile of community-acquired (CA)-MRSA nasal carriage in the Iranian samples.

Materials And Methods: A total of 25 CA-MRSA were isolated from the anterior nares of 410 healthy preschool children. Read More

R Soc Open Sci 2021 Mar 10;8(3):201991. Epub 2021 Mar 10.

Division of Molecular Microbiology, School of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, UK.

, also known as Group A Streptococcus (GAS), is a Gram-positive human-exclusive pathogen, responsible for more than 500 000 deaths annually worldwide. Upon infection, GAS commonly triggers mild symptoms such as pharyngitis, pyoderma and fever. However, recurrent infections or prolonged exposure to GAS might lead to life-threatening conditions. Read More

Front Pharmacol 2021 20;12:625233. Epub 2021 Apr 20.

Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS, United States.

In order to develop improved anxiolytic drugs, 8-substituted analogs of triazolam were synthesized in an effort to discover compounds with selectivity for α2/α3 subunit-containing GABA subtypes. Two compounds in this series, XLi-JY-DMH (6-(2-chlorophenyl)-8-ethynyl-1-methyl-4H-benzo [f][1,2,4]triazolo[4,3-a][1,4]diazepine) and SH-TRI-108 [(E)-8-ethynyl-1-methyl-6-(pyridin-2-yl)-4H-benzo [f][1,2,4]triazolo[4,3-a][1,4]diazepine], were evaluated for and properties associated with GABA subtype-selective ligands. In radioligand binding assays conducted in transfected HEK cells containing rat αXβ3γ2 subtypes (X = 1,2,3,5), no evidence of selectivity was obtained, although differences in potency relative to triazolam were observed overall (triazolam > XLi-JY-DMH > SH-TRI-108). Read More

Nature 2021 May 6. Epub 2021 May 6.

Nat Cell Biol 2021 May 6. Epub 2021 May 6.

Department of Surgery, University of Michigan, Ann Arbor, MI, USA.

Major histocompatibility complex-I (MHC-I) presents tumour antigens to CD8 T cells and triggers anti-tumour immunity. Humans may have 30,000-60,000 long noncoding RNAs (lncRNAs). However, it remains poorly understood whether lncRNAs affect tumour immunity. Read More

Cell Death Dis 2021 May 6;12(5):452. Epub 2021 May 6.

Centre for Neuroscience and Nanotechnology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41125, Modena, Italy.

One of the critical events that regulates muscle cell differentiation is the replacement of the lamin B receptor (LBR)-tether with the lamin A/C (LMNA)-tether to remodel transcription and induce differentiation-specific genes. Here, we report that localization and activity of the LBR-tether are crucially dependent on the muscle-specific chaperone HSPB3 and that depletion of HSPB3 prevents muscle cell differentiation. We further show that HSPB3 binds to LBR in the nucleoplasm and maintains it in a dynamic state, thus promoting the transcription of myogenic genes, including the genes to remodel the extracellular matrix. Read More

Shock 2021 May 4. Epub 2021 May 4.

Karolinska Institutet, Department of Clinical Sciences, Danderyd University Hospital, Division of Internal medicine and Infectious diseases, Stockholm, Sweden.

Background: Endothelial and microvascular dysfunction may be a key pathogenic feature of severe COVID-19. The aim of this study was to investigate endothelial-dependent and endothelial-independent skin microvascular reactivity in patients with critical COVID-19.

Methods: Twelve patients with COVID-19 treated with non-invasive or invasive mechanical ventilation were included in the study. Read More

Burns 2020 Dec 15. Epub 2020 Dec 15.

Fujian Provincial Key Laboratory of Burn and Trauma, Fujian Burn Institute, Fujian Burn Medical Center, Fujian Medical University Union Hospital, Fuzhou 350001, Fujian, China. Electronic address:

Background: Patients with severe burns often show systemic coagulation changes in the early stage and even develop extensive coagulopathy. Previous studies have confirmed that soluble TREM-like transcript-1 (sTLT-1) mediates a novel mechanism of haemostasis and thrombosis in inflammatory vascular injury. At present, the role of sTLT-1 in patients with severe burns is not well known. Read More

Burns 2021 Apr 20. Epub 2021 Apr 20.

Department of Anesthesiology, University of Kansas Medical Center, Kansas City, KS 66160, USA.

Acute pain is prevalent following burn injury and can often transition to chronic pain. Prolonged acute pain is an important risk factor for chronic pain and there is little preclinical research to address this problem. Using a mouse model of second-degree burn, we investigated whether pre-existing stress influences pain(sensitivity) after a burn injury. Read More

Ann Cardiol Angeiol (Paris) 2021 May 3. Epub 2021 May 3.

Service de réanimation médicale, institut de cardiologie, groupe hospitalier Pitié-Salpêtrière, 75651 Paris cedex 13, France.

Hydrostatic pulmonary edema is a well-known complication of veinoarterial extracorporeal membrane oxygenation (VA-ECMO) caused by increased left ventricle afterload due to reverse blood flow in the aorta. Several techniques are commonly used for left ventricle venting such as intra-aortic balloon pump, Impella® (Abiomed, Danvers, MA), central surgical cannulation or Rahskind atrial septostomy. We reported two cases of hydrostatic pulmonary edema in patients under VA-ECMO for whom it was decided to perform Rashkind technique. Read More

J Am Coll Radiol 2021 May;18(5S):S13-S36

Specialty Chair, Atlanta VA Health Care System and Emory University, Atlanta, Georgia.

Head trauma (ie, head injury) is a significant public health concern and is a leading cause of morbidity and mortality in children and young adults. Neuroimaging plays an important role in the management of head and brain injury, which can be separated into acute (0-7 days), subacute (<3 months), then chronic (>3 months) phases. Over 75% of acute head trauma is classified as mild, of which over 75% have a normal Glasgow Coma Scale score of 15, therefore clinical practice guidelines universally recommend selective CT scanning in this patient population, which is often based on clinical decision rules. Read More

Biochem Biophys Res Commun 2021 May 3;559:217-221. Epub 2021 May 3.

Beijing Institute of Basic Medical Sciences, Beijing, 100850, China; School of Pharmacy, Jiamus University, Jiamusi, 154007, China; Anhui Medical University, 81 Meishan Road, Hefei, 230032, China; College of Life Science, Henan Normal University, 46 Jianshe Road, Xinxiang, 473007, China. Electronic address:

Ornithine transcarbamylases (OTC), a key enzyme in urea cycle, is an important marker for some liver injury or diseases. However, whether OTC could be a sensitive indicator for liver dysfunction under sleep disturbance condition remains unknown. The present study aimed to explore the circadian oscillation expression of OTC and its significance in disturbed sleep condition. Read More

Accid Anal Prev 2021 May 3;157:106159. Epub 2021 May 3.

Department of Civil Engineering, The University of British Columbia, Canada. Electronic address:

The use of Extreme Value Theory (EVT) models for traffic conflict-based crash estimation is becoming increasingly popular with considerable recent advances achieved. The latest advances include developing EVT models that combine several conflict indicators and the use of data from several sites to increase the sample size of conflict extremes. Nevertheless, one important issue while developing EVT models is accounting for the unobserved heterogeneity across different conflict observation sites and road user behaviours which can lead to biased and inefficient parameter estimates and erroneous inferences. Read More