233,237 results match your criteria Shock Hypovolemic


Sepsis-Associated Acute Kidney Injury: A Problem Deserving of New Solutions.

Nephron 2019 Apr 24:1-5. Epub 2019 Apr 24.

Center for Critical Care Nephrology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

Sepsis-associated acute kidney injury (S-AKI) significantly worsens patient prognosis, and recent evidence suggests that the injury process begins early and may be sustained by therapies used to treat the sepsis (e.g., fluids resuscitation, antibiotics). Read More

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https://www.karger.com/Article/FullText/500167
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http://dx.doi.org/10.1159/000500167DOI Listing
April 2019
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Geriatric Polytrauma-Cardiovascular and Immunologic Response in a Murine Two-Hit Model of Trauma.

J Surg Res 2019 Apr 21;241:87-94. Epub 2019 Apr 21.

Department of Orthopaedic Trauma, RWTH Aachen University, Aachen, Germany.

Background: The aims of the present study were to establish a clinically relevant two-hit model with trauma/hemorrhage followed by sepsis in older mice and investigate age-dependent cardiovascular and immunologic specificities under these conditions.

Materials And Methods: In aged mice (12, 18, and 24 mo old), a femur fracture followed by hemorrhage was induced. After resuscitation, animals were monitored for 72 h before sepsis was induced. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00224804193016
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http://dx.doi.org/10.1016/j.jss.2019.03.053DOI Listing
April 2019
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Strategy focused on clinical parameters of microcirculation to resuscitate patients in septic shock: do not forget any tools.

Anaesth Crit Care Pain Med 2019 Apr 21. Epub 2019 Apr 21.

Bloomsbury Institute of Intensive Care Medicine, University College London, London, UK.

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http://dx.doi.org/10.1016/j.accpm.2019.04.009DOI Listing

Spatial distribution of major bacterial species and different volatile fatty acids in a two-phase anaerobic biofilm reactor with PVA gel beads as bio-carrier.

Prep Biochem Biotechnol 2019 Apr 24:1-14. Epub 2019 Apr 24.

b Department of Civil Engineering , Indian Institute of Technology , Roorkee , India.

Conventional completely mixed anaerobic treatment systems limit the chances of the different species of bacteria to spatially group together according to their mutual cooperation and as a result, show a lower efficiency and vulnerability towards shock situations. It is interesting to know about the stratification of the different bacterial species participating in the degradation process and the intermediates that they produce. In this study, we established and optimized a two-phase anaerobic packed bed biofilm reactor system (AnPBR) with porous PVA gel beads used as bio-carriers and ran the reactor system in a steady state to observe the VFAs produced along with the microbial diversity of the predominant species at different stages of the reactor system. Read More

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http://dx.doi.org/10.1080/10826068.2019.1605525DOI Listing

A Rare Case of Lethal Prenatal-Onset Infantile Cortical Hyperostosis.

Yonsei Med J 2019 May;60(5):484-486

Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Infantile cortical hyperostosis, or Caffey's disease, usually presents with typical radiological features of soft tissue swelling and cortical thickening of the underlying bone. The disease can be fatal when it presents antenatally, especially before a gestational age of 35 weeks. This fatal, premature form of the disease is known to occur in various ethnic groups around the globe, and approximately 30 cases have been reported in English literature. Read More

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http://dx.doi.org/10.3349/ymj.2019.60.5.484DOI Listing

Cigarette Smoke-Induced Oxidative Stress and Autophagy in Human Alveolar Epithelial Cell Line (A549 Cells).

Adv Exp Med Biol 2019 Apr 24. Epub 2019 Apr 24.

Department of Pharmacology, Medical University, Bialystok, Poland.

Chronic exposure to cigarette smoke (CS) causes structural and functional changes in the respiratory tract. It is a major risk factor for cardiovascular and systemic pulmonary diseases. The aim of this study was to investigate the effect of acute CS exposure (2 h) on oxidative stress, heat shock protein 70 (HSP70) expression, autophagy (LC3 expression), and oxidative stress (DCF fluorescence) in human alveolar epithelial cell line A549. Read More

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http://dx.doi.org/10.1007/5584_2019_373DOI Listing

Reduced ambient temperature exacerbates SIRS-induced cardiac autonomic dysregulation and myocardial dysfunction in mice.

Basic Res Cardiol 2019 Apr 23;114(3):26. Epub 2019 Apr 23.

Institute of Molecular Cell Biology, Jena University Hospital, Friedrich Schiller University, Hans-Knöll-Straße 2, 07745, Jena, Germany.

Sepsis-induced myocardial depression (SIMD) is an early and frequent consequence of the infection-induced systemic inflammatory response syndrome. In homiotherms, variations in ambient temperature (T) outside the thermoneutral zone induce thermoregulatory responses mainly driven by a gradually increased sympathetic activity, which may affect disease severity. We hypothesized that thermoregulatory responses upon reduced T exposition aggravate SIMD in mice. Read More

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http://dx.doi.org/10.1007/s00395-019-0734-1DOI Listing

[Cardiac implantable electronic devices : Electromagnetic interference from electrocauterization, lithotripsy and physiotherapy].

Herzschrittmacherther Elektrophysiol 2019 Apr 23. Epub 2019 Apr 23.

Medizinische Klinik und Poliklinik I, Klinikum der Universität München, Marchioninistraße 15, 81377, München, Deutschland.

The management of patients with a cardiac implantable electronic device (CIED) poses a particular challenge in the peri-interventional and perioperative medical environment due to the many forms of possible electromagnetic interference. Although the devices encountered nowadays are of increasing complexity, the vast majority of procedures can be safely performed in patients. The existing position statements and recommendations, however, have a low level of evidence and are often contradictory. Read More

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http://dx.doi.org/10.1007/s00399-019-0620-4DOI Listing

Arterial waveform morphomics during hemorrhagic shock.

Eur J Trauma Emerg Surg 2019 Apr 23. Epub 2019 Apr 23.

R Adams Cowley Shock Trauma Center, 22 S. Greene Street, Baltimore, MD, 21201, USA.

Purpose: The arterial pressure waveform is a composite of multiple interactions, and there may be more sensitive and specific features associated with hemorrhagic shock and intravascular volume depletion than systolic and/or diastolic blood pressure (BP) alone. The aim of this study was to characterize the arterial pressure waveform in differing grades of hemorrhage.

Methods: Ten anesthetized swine (70-90 kg) underwent a 40% controlled exponential hemorrhage. Read More

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http://dx.doi.org/10.1007/s00068-019-01140-2DOI Listing

Usefulness of the heparin-binding protein level to diagnose sepsis and septic shock according to Sepsis-3 compared with procalcitonin and C reactive protein: a prospective cohort study in China.

BMJ Open 2019 Apr 23;9(4):e026527. Epub 2019 Apr 23.

Department of Clinical Laboratory, Zhejiang University School of Medicine Sir Run Run Shaw Hospital, Hangzhou, Zhejiang, China.

Objectives: Our aim was to assess the release level of heparin-binding protein (HBP) in sepsis and septic shock under the (Sepsis-3).

Design: Prospective cohort study.

Setting: A general teaching hospital in China. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-026527DOI Listing

Takotsubo cardiomyopathy secondary to haemophagocytic lymphohistiocytosis in HIV patients: a comprehensive review.

BMJ Case Rep 2019 Apr 23;12(4). Epub 2019 Apr 23.

Internal Medicine, Allama Iqbal Medical College, Lahore, Pakistan.

Haemophagocytic lymphohistiocytosis (HLH) is an immune dysregulation disorder with variable presentations and non-specific features making it extremely difficult to diagnose early in the clinical course. Here, we are presenting a case of a young man who presented in cardiogenic shock with findings of anterolateral wall ischaemia on ECG. Echocardiography findings were consistent with takotsubo cardiomyopathy (TCM). Read More

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http://dx.doi.org/10.1136/bcr-2018-226599DOI Listing

Periorbital necrotising fasciitis with underlying undiagnosed hepatitis C infection.

BMJ Case Rep 2019 Apr 23;12(4). Epub 2019 Apr 23.

Royal Devon and Exeter NHS Foundation Trust, Exeter, UK.

We report the case of a 56-year-old man, previously well, who presented with a spontaneous right-sided periorbital necrotising soft tissue infection and subsequently found to have undiagnosed hepatitis C and liver cirrhosis. The patient presented with rapid onset right eye pain, periorbital swelling and septic shock. CT scan revealed diffuse inflammatory changes to the soft tissue anterior to the right eye. Read More

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http://dx.doi.org/10.1136/bcr-2017-223720DOI Listing

The single nucleotide variant rs2868371 associates with the risk of mortality in non-small cell lung cancer patients: A multicenter prospective validation.

Radiother Oncol 2019 Apr 6;136:29-36. Epub 2019 Apr 6.

Department of Radiation Oncology, University Hospital Virgen del Rocío, Seville, Spain; Instituto de Biomedicina de Sevilla (IBIS/HUVR/CSIC/Universidad de Sevilla), Spain. Electronic address:

Background And Purpose: Definitive radiation therapy (RT) with or without chemotherapy has become the standard treatment for non-metastatic unresectable non-small cell lung cancer (NSCLC). However, treatment outcomes can differ substantially and patients' genetic background could play a crucial role. Potential associations between single-nucleotide polymorphisms (SNP) in Heat shock protein beta-1 (HSPB1) and survival have been reported in prior single-institution retrospective reports. Read More

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http://dx.doi.org/10.1016/j.radonc.2019.03.025DOI Listing

Right single coronary artery as an incidental finding in Takotsubo syndrome and acute heart failure: Case report and review of the literature.

Rev Port Cardiol 2019 Apr 20. Epub 2019 Apr 20.

Department of Cardiology, Centro Hospitalar de Vila Nova de Gaia Espinho, Vila Nova de Gaia, Portugal.

Introduction: Single coronary artery (SCA) with no associated congenital heart disease is a rare congenital anomaly. Most cases are asymptomatic and incidental findings, but SCA can cause ischemia, congestive heart failure, and sudden cardiac death (SCD).

Case Report: A 44-year-old woman presented with Takotsubo cardiomyopathy and cardiogenic shock. Read More

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http://dx.doi.org/10.1016/j.repc.2018.06.013DOI Listing

Molecular epidemiology of Babesia vogeli in dogs from the southeastern region of Rio de Janeiro, Brazil.

Vet Parasitol Reg Stud Reports 2018 Aug 19;13:160-165. Epub 2018 Jun 19.

Department of Epidemiology and Public Health, Veterinary Institute, Federal Rural University of Rio de Janeiro, Br 465, km 7, Seropedica, Rio de Janeiro 23897-000, Brazil. Electronic address:

Hemoparasitic diseases are prominent in domestic animals, particularly in Brazil, a tropical country with a wide range of vectors. This study investigated the epidemiology of Babesia vogeli in the whole blood of dogs from the southeastern region of Rio de Janeiro, Brazil. Whole blood samples from 390 dogs were screened for the presence of B. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24059390183005
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http://dx.doi.org/10.1016/j.vprsr.2018.06.004DOI Listing
August 2018
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[Current status of antibiotic therapy for Staphylococcus aureus sepsis in children].

Zhongguo Dang Dai Er Ke Za Zhi 2019 Apr;21(4):387-392

Department of Respiratory Medicine, Children's Hospital of Chongqing Medical University, Chongqing 400014, China.

Objective: To investigate the current status of empirical antibiotic therapy for children with Staphylococcus aureus sepsis and the effect of therapeutic paradigm on prognosis based on a retrospective analysis.

Methods: A total of 78 children with Staphylococcus aureus sepsis who were admitted from January 2014 to August 2017 were enrolled. According to the preferred empirical antibiotics before the detection of Staphylococcus aureus by blood culture, these children were divided into a carbapenem group with 16 children, a β-lactam group with 37 children, a vancomycin group with 15 children and a vancomycin+β-lactam group with 10 children. Read More

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April 2019
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Kawasaki disease triggered by parvovirus infection: an atypical case report of two siblings.

J Med Case Rep 2019 Apr 24;13(1):104. Epub 2019 Apr 24.

University Department promise "G. D'Alessandro", University of Palermo, Palermo, Italy.

Background: There are reports of the familial occurrence of Kawasaki disease but only a few reports described Kawasaki disease in siblings. However, the familial cases were not simultaneous. In these patients the idea of infective agents as trigger must be considered. Read More

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http://dx.doi.org/10.1186/s13256-019-2028-5DOI Listing

Extended Indications for Extracorporeal Membrane Oxygenation in the Operating Room.

J Intensive Care Med 2019 Apr 23:885066619842537. Epub 2019 Apr 23.

2 Mater Misericordiae University Hospital (MMUH), University College Dublin, Dublin, Ireland.

Background: The use of extracorporeal life support (ECLS) for cardiorespiratory support is increasing. Traditional absolute contraindications are currently deemed relative contraindications. Extracorporeal life support is now considered for a wider cohort of patients on a case-by-case basis. Read More

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http://dx.doi.org/10.1177/0885066619842537DOI Listing

Nucleus, Cytoskeleton, and Mitogen-Activated Protein Kinase p38 Dynamics during In Vitro Maturation of Porcine Oocytes.

Animals (Basel) 2019 Apr 13;9(4). Epub 2019 Apr 13.

Department of Animal Science, National Chung Hsing University, Taichung 40227, Taiwan.

The mitogen-activated kinase (MAPK) p38, a member of the MAPK subfamily, is conserved in all mammalian cells and plays important roles in response to various physiologic cues, including mitogens and heat shock. In the present study, MAPK p38 protein expression in porcine oocytes was analyzed during in vitro maturation (IVM) by Western blotting and immunocytochemistry. The levels of p-p38 or activated p38 and p38 expression were at the lowest in the germinal vesicle (GV) stage oocyte, gradually rising at the germinal vesicle breakdown (GVBD) and then reaching a plateau throughout the IVM culture ( < 0. Read More

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http://dx.doi.org/10.3390/ani9040163DOI Listing

Low Voltage Electric Injury induced Atrial Fibrillation as a Presenting Feature of Wolff-Parkinson-White Syndrome: A Case Report.

Oman Med J 2013 Nov;28(6):e061

Department of Cardilogy, Shere-Kashmir-Institute of Medical Sciences (SKIMS) Srinagar, J&K. 190011.

Electric injury can cause a variety of cardiac arrhythmias. Atrial fibrillation as a result of such injury is very rare. We present a case of a young asymptomatic patient who developed acute atrial fibrillation with antegrade conduction over the atrioventricular bypass tract and very high ventricular rate after accidental low voltage electric injury, which was reverted successfully by DC shock. Read More

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http://dx.doi.org/10.5001/omj.2013.130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458441PMC
November 2013

Survey of subjective "God encounter experiences": Comparisons among naturally occurring experiences and those occasioned by the classic psychedelics psilocybin, LSD, ayahuasca, or DMT.

PLoS One 2019 23;14(4):e0214377. Epub 2019 Apr 23.

Council on Spiritual Practices, Occidental, California, United States of America.

Naturally occurring and psychedelic drug-occasioned experiences interpreted as personal encounters with God are well described but have not been systematically compared. In this study, five groups of individuals participated in an online survey with detailed questions characterizing the subjective phenomena, interpretation, and persisting changes attributed to their single most memorable God encounter experience (n = 809 Non-Drug, 1184 psilocybin, 1251 lysergic acid diethylamide (LSD), 435 ayahuasca, and 606 N,N-dimethyltryptamine (DMT)). Analyses of differences in experiences were adjusted statistically for demographic differences between groups. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214377PLOS
April 2019
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Risk Factors for Predicting Mortality among Old Patients with Acute Myocardial Infarction during Hospitalization.

Heart Surg Forum 2019 Apr 16;22(2):E165-E169. Epub 2019 Apr 16.

Department of Cardiology, Fuxing Hospital, Capital Medical University, Beijing 100038, China.

Objective: To explore the risk factors to predict mortality among acute myocardial infarction (AMI) patients aged ≥ 80 years during their hospitalization.

Methods: A cohort of AMI patients aged ≥ 80 years hospitalized in our hospital were recruited from 2005 to 2014. Variables, including demographics, medical history, hemodynamic condition and laboratory results, were collected and analyzed to find risk factors predicting mortality during hospitalization. Read More

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http://dx.doi.org/10.1532/hsf.2265DOI Listing

Quasimonoenergetic Proton Bunch Acceleration Driven by Hemispherically Converging Collisionless Shock in a Hydrogen Cluster Coupled with Relativistically Induced Transparency.

Phys Rev Lett 2019 Jan;122(1):014804

Graduate School of Energy Science, Kyoto University, Gokasho, Uji, Kyoto 611-0011, Japan.

An approach for accelerating a quasimonoenergetic proton bunch via a hemispherically converging collisionless shock created in laser-cluster interactions at the relativistically induced transparency (RIT) regime is studied using three-dimensional particle-in-cell simulations. By the action of focusing a petawatt class laser pulse onto a micron-size spherical hydrogen cluster, a crescent-shaped collisionless shock is launched at the laser-irradiated hemisphere and propagates inward. The shock converges at the sphere center in concurrence with the onset of the RIT, thereby allowing the proton bunch to be pushed out from the shock surface in the laser propagation direction. Read More

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http://dx.doi.org/10.1103/PhysRevLett.122.014804DOI Listing
January 2019

Deployment of acute mechanical circulatory support devices via the axillary artery.

Expert Rev Cardiovasc Ther 2019 Apr 23:1-8. Epub 2019 Apr 23.

b The CardioVascular Center, Tufts Medical Center , Boston , MA , USA.

Introduction: Use of acute mechanical circulatory support (MCS) devices for high-risk cardiac intervention, cardiogenic shock, and advanced heart failure is growing. Alternate vascular access options for these devices remains a clinical challenge. Building on experience from trans-aortic valve replacement procedures, the axillary artery is becoming a common access route for acute MCS and represents an important advance in the development of acute MCS technologies. Read More

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http://dx.doi.org/10.1080/14779072.2019.1606712DOI Listing

Clinical use of cryopoor plasma continuous rate infusion in critically ill, hypoalbuminemic dogs.

J Vet Emerg Crit Care (San Antonio) 2019 Apr 22. Epub 2019 Apr 22.

The Emergency and Critical Care Service, The Ohio State University Veterinary Medical Center Veterinary Clinical Sciences, Columbus, OH.

Objective: To investigate the impact of cryopoor plasma (CPP) continuous rate infusion (CRI) on albumin concentration and colloid osmotic pressure (COP) in critically ill dogs with hypoalbuminemia.

Design: Retrospective study between 2013 and 2015 with a 90-day follow-up on survivors.

Setting: University teaching hospital. Read More

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http://dx.doi.org/10.1111/vec.12834DOI Listing

Treatment of human neuroblastoma cell line SH-SY5Y with HSP27 siRNA tagged-exosomes decreased differentiation rate into mature neurons.

J Cell Physiol 2019 Apr 22. Epub 2019 Apr 22.

Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Heat shock proteins (HSPs) participate in the regulation of different cell activities in response to stimuli. By applying different strategies, the modulation of heat shock proteins is at the center of attention. Conventional delivery approaches are not fully encouraged due to cytotoxicity and immunogenicity issues. Read More

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http://dx.doi.org/10.1002/jcp.28704DOI Listing

Red blood cell transfusion in critically ill patients with traumatic brain injury: an international survey of physicians' attitudes.

Can J Anaesth 2019 Apr 22. Epub 2019 Apr 22.

CHU de Québec - Université Laval Research Center, Population Health and Optimal Health Practices Research Unit, Traumatology - Emergency - Critical Care Medicine, CHU de Québec-Université Laval (Hôpital de l'Enfant-Jésus), 1401, 18e rue, Québec City, QC, G1J 1Z4, Canada.

Introduction: Restrictive transfusion strategies have been advocated in critically ill patients. Nevertheless, considerable uncertainty exists regarding optimal transfusion thresholds in traumatic brain injury (TBI) patients because the injured brain is susceptible to hypoxemic damage. We aimed to identify the determinants of red blood cell (RBC) transfusion and the perceived optimal transfusion thresholds in adult patients with moderate-to-severe TBI. Read More

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http://dx.doi.org/10.1007/s12630-019-01369-wDOI Listing

Anaphylactic Degranulation of Mast Cells: Focus on Compound Exocytosis.

J Immunol Res 2019 18;2019:9542656. Epub 2019 Mar 18.

Department of Cell and Developmental Biology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.

Anaphylaxis is a notorious type 2 immune response which may result in a systemic response and lead to death. A precondition for the unfolding of the anaphylactic shock is the secretion of inflammatory mediators from mast cells in response to an allergen, mostly through activation of the cells via the IgE-dependent pathway. While mast cells are specialized secretory cells that can secrete through a variety of exocytic modes, the most predominant mode exerted by the mast cell during anaphylaxis is compound exocytosis-a specialized form of regulated exocytosis where secretory granules fuse to one another. Read More

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http://dx.doi.org/10.1155/2019/9542656DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442490PMC

Ciprofloxacin infusion versus third generation cephalosporin as a surgical prophylaxis for percutaneous nephrolithotomy: a randomized study.

Cent European J Urol 2019 14;72(1):57-61. Epub 2019 Jan 14.

Menoufia University, Faculty of Medicine, Department of Urology, Shbeen el Kom, Egypt.

Introduction: Percutaneous nephrolithotomy (PCNL) is considered a clean-contaminated surgical procedure. The American Urological Association has recommended different preoperative antimicrobial prophylaxis for various urological procedures to prevent surgical site infections, postoperative fever, and possible sepsis. The European Association of Urology (EAU) antibiotic guidelines endorse giving either a second or third-generation cephalosporin, trimethoprim-sulfamethoxazole, fluoroquinolone or aminopenicillin with a β-lactamase inhibitor. Read More

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http://dx.doi.org/10.5173/ceju.2019.1698DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469015PMC
January 2019

Disagreement in cardiac output measurements between fourth-generation FloTrac and critical care ultrasonography in patients with circulatory shock: a prospective observational study.

J Intensive Care 2019 11;7:21. Epub 2019 Apr 11.

2Department of Critical Care, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Background: Cardiac output measurements may inform diagnosis and provide guidance of therapeutic interventions in patients with hemodynamic instability. The FloTrac™ algorithm uses uncalibrated arterial pressure waveform analysis to estimate cardiac output. Recently, a new version of the algorithm has been developed. Read More

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http://dx.doi.org/10.1186/s40560-019-0373-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460822PMC

Production of a Functional Factor, p40, by GG Is Promoted by Intestinal Epithelial Cell-secreted Extracellular Vesicles.

Infect Immun 2019 Apr 22. Epub 2019 Apr 22.

Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Vanderbilt; University Medical Center, Nashville, TN, 37232, USA

The symbiotic relationship between the gut microbiome and the host provides a nutrient-rich environment for gut microbes and has beneficial effects on host health. Although the composition of the gut microbiome is known to be influenced by both host genetics and environmental factors, host effects on the activities and functions of the gut microbial communities remain poorly understood. Intestinal epithelial cells exert front-line responses to gut microbes and contribute to maintaining a healthy intestinal homeostasis. Read More

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http://dx.doi.org/10.1128/IAI.00113-19DOI Listing

Right-to-left ventricular end diastolic diameter ratio in severe sepsis and septic shock.

J Crit Care 2019 Apr 15. Epub 2019 Apr 15.

Centro de Salud La Lobilla, Estepona, Málaga, Spain.

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http://dx.doi.org/10.1016/j.jcrc.2019.04.008DOI Listing

Glyphosate induces toxicity and modulates calcium and NO signaling in zebrafish embryos.

Biochem Biophys Res Commun 2019 Apr 19. Epub 2019 Apr 19.

Ion Channel Biology Lab, Department of Biotechnology, Indian Institute of Technology Hyderabad (IITH), Kandi, Telangana, 502285, India. Electronic address:

Glyphosate, an herbicide used worldwide, has emerged as a pollutant. However, its toxic effects are debated by regulatory authorities. Therefore, it is essential to keep the use of such chemicals under continuous observation, and their effects must be re-evaluated. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.04.074DOI Listing

The Use of Cardiotonic Drugs in Neonates.

Clin Perinatol 2019 Jun 30;46(2):273-290. Epub 2019 Mar 30.

Brighton and Sussex Medical School, University of Sussex, Brighton, UK; Department of Neonatology, Brighton & Sussex University Hospitals NHS Trust, Brighton, UK.

There is a distinct lack of age-appropriate cardiotonic drugs, and adult derived formulations continue to be administered, without evidence-based knowledge on their dosing, safety, efficacy, and long-term effects. Dopamine remains the most commonly studied and prescribed cardiotonic drug in the neonatal intensive care unit (NICU), but evidence of its effect on endorgan perfusion still remains. Unlike adult and pediatric critical care, there are significant gaps in our knowledge on the use of various cardiotonic drugs in various forms of circulatory failure in the NICU. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00955108193002
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http://dx.doi.org/10.1016/j.clp.2019.02.010DOI Listing
June 2019
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Acute Cardiac Tamponade: An Adult Simulation Case for Residents.

MedEdPORTAL 2016 Sep 23;12:10466. Epub 2016 Sep 23.

Assistant Professor of Emergency Medicine, Central Michigan University College of Medicine.

Introduction: This case was designed to be an interprofessional scenario to assist the learner in the approach to a patient with cardiac tamponade. This resource provides information and materials for a high-fidelity simulation scenario that is appropriate for learners at multiple levels. Each learner has the opportunity to interact with embedded patient actors. Read More

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http://dx.doi.org/10.15766/mep_2374-8265.10466DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6464418PMC
September 2016

The mechanical behavior of brain surrogates manufactured from silicone elastomers.

J Mech Behav Biomed Mater 2019 Apr 16;95:180-190. Epub 2019 Apr 16.

Department of Mechanical Engineering, Iowa State University of Science and Technology, 2529 Union Drive, Ames, IA, 50011, USA. Electronic address:

The ongoing conflict against terrorism has resulted in an escalation of blast-induced traumatic brain injuries (bTBI) caused by improvised explosive devices (IEDs). The destructive IEDs create a blast wave that travels through the atmosphere. Blast-induced traumatic brain injuries, attributed to the blast wave, can cause life-threatening injuries and fatalities. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17516161183167
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http://dx.doi.org/10.1016/j.jmbbm.2019.04.005DOI Listing
April 2019
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Comparative proteomic analysis of two sesame genotypes with contrasting salinity tolerance in response to salt stress.

J Proteomics 2019 Apr 19. Epub 2019 Apr 19.

Key Laboratory of Biology and Genetic Improvement of Oil Crops, Ministry of Agriculture, Oil Crops Research Institute, Chinese Academy of Agricultural Sciences, Wuhan 430062, China. Electronic address:

Sesame is one of the most important oilseed crops and has high nutritional value. The yield and quality of sesame are severely affected by high salinity in coastal and semi-arid/arid regions. In this study, the phenotypic, physiological, and proteomic changes induced by salt treatment were analyzed in salt-tolerant (G441) and salt-sensitive (G358) seedlings. Read More

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http://dx.doi.org/10.1016/j.jprot.2019.04.017DOI Listing
April 2019
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Impella use in acute myocardial infarction complicated by cardiogenic shock and cardiac arrest : Analysis of 10 years registry data.

Resuscitation 2019 Apr 19. Epub 2019 Apr 19.

Department of Heart Disease, Haukeland University Hospital, Bergen, Norway; Department of Clinical Medicine, University of Bergen, Bergen, Norway.

Aims: To assess characteristics and outcome of patients treated with Impella for acute myocardial infarction (AMI) complicated by severe cardiogenic shock (CS) or cardiac arrest (CA).

Methods And Results: From 2008 through 2017, 92 patients with AMI complicated by CS were treated with Impella. Survival varied according to clinical presentation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03009572193013
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http://dx.doi.org/10.1016/j.resuscitation.2019.04.022DOI Listing
April 2019
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Dengue virus nonstructural protein 1 activates platelets via Toll-like receptor 4, leading to thrombocytopenia and hemorrhage.

PLoS Pathog 2019 Apr 22;15(4):e1007625. Epub 2019 Apr 22.

Department of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

Dengue virus (DENV) infection, the most common mosquito-transmitted viral infection, can cause a range of diseases from self-limiting dengue fever to life-threatening dengue hemorrhagic fever and shock syndrome. Thrombocytopenia is a major characteristic observed in both mild and severe dengue disease and is significantly correlated with the progression of dengue severity. Previous studies have shown that DENV nonstructural protein 1 (NS1), which can be secreted into patients' blood, can stimulate immune cells via Toll-like receptor 4 (TLR4) and can cause endothelial leakage. Read More

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http://dx.doi.org/10.1371/journal.ppat.1007625DOI Listing

Anti-interferon-α receptor 1 antibodies attenuate inflammation and organ injury following hemorrhagic shock.

J Trauma Acute Care Surg 2019 May;86(5):881-890

From the Elmezzi Graduate School of Molecular Medicine, (J.C., W-L.Y., P.W.); Center for Immunology and Inflammation, (J.C., W-L.Y., Z.W., P.W.) The Feinstein Institute for Medical Research, Manhasset; Department of Surgery, Zucker School of Medicine at Hofstra/Northwell, (W-L.Y., J.T.M., P.W.) Hempstead, New York.

Background: Hemorrhagic shock (HS) is a life-threatening condition resulting from rapid and significant loss of intravascular volume, leading to hemodynamic instability and death. Inflammation contributes to the multiple organ injury in HS. Type I interferons (IFNs), such as IFN-α and IFN-β, are a family of cytokines that regulate the inflammatory response through binding to IFN-α receptor (IFNAR) which consists of IFNAR1 and IFNAR2 chains. Read More

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http://dx.doi.org/10.1097/TA.0000000000002214DOI Listing

Risk Factors and Outcomes for Sepsis after Appendectomy in Adults.

Surg Infect (Larchmt) 2019 Apr 20. Epub 2019 Apr 20.

Department of Surgery, Icahn School of Medicine at Mount Sinai, New York, New York.

Sepsis is an uncommon occurrence after appendectomy, but the morbidity and mortality of patients who develop sepsis after appendectomy remains exceedingly high. The purpose of this study is to identify risk factors and adverse post-operative outcomes associated with sepsis after appendectomy in adults. The American College of Surgery National Surgical Quality Improvement Program participant user database was queried from 2012 to 2015. Read More

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https://www.liebertpub.com/doi/10.1089/sur.2019.003
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http://dx.doi.org/10.1089/sur.2019.003DOI Listing
April 2019
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Tension pneumothorax-induced Takotsubo syndrome: A case report.

Medicine (Baltimore) 2019 Apr;98(16):e15190

Rationale: Takotsubo syndrome (TTS) is a form of acute and usually reversible heart failure syndrome. Transient left ventricular dysfunction and electrocardiographic changes could mimic acute coronary syndrome but there are actually no obstructive coronary lesions.

Patient Concerns: A 76-year-old woman with chronic lung disease developed spontaneous tension pneumothorax with the presentation of severe dyspnea, respiratory failure, left ventricular dysfunction, and anterior wall ST-segment elevation on 12-lead electrocardiogram. Read More

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http://dx.doi.org/10.1097/MD.0000000000015190DOI Listing

Review of Existing Scoring Systems For Massive Blood Transfusion in Trauma Patients: Where Do We Stand?

Shock 2019 Apr 16. Epub 2019 Apr 16.

Department of Surgery, Trauma Surgery, Hamad General Hospital, Doha, Qatar.

Background: Uncontrolled bleeding is the main cause of the potential preventable death in trauma patients. Accordingly, we reviewed all the existing scores for massive transfusion posttraumatic hemorrhage and summarized their characteristics, thus making it easier for the reader to have a global view of these scores - how they were created, their accuracy and to which population they apply.

Methods: A narrative review with a systematic search method to retrieve the journal articles on the predictive scores or models for massive transfusion was carried out. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001359DOI Listing

Effect of Vasopressors on The Macro- and Microcirculation During Systemic Inflammation In Humans in vivo.

Shock 2019 Apr 16. Epub 2019 Apr 16.

Department of Intensive Care Medicine, Radboud university medical center, Nijmegen, the Netherlands.

Aim: Comparing the effects of different vasopressors in septic shock patients is hampered by high heterogeneity and the fact that current guidelines dictate the use of norepinephrine. Herein, we studied the effects of three vasopressor agents, norepinephrine, phenylephrine and vasopressin, on the macro- and microcirculation during experimental human endotoxemia, a standardized, controlled model of systemic inflammation in humans in vivo.

Methods: We performed a randomized controlled study in which 40 healthy male volunteers were assigned to a five-hour infusion of either 0. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001357DOI Listing
April 2019
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Norepinephrine vs vasopressin: which vasopressor should be discontinued first in septic shock? a meta-analysis.

Shock 2019 Apr 16. Epub 2019 Apr 16.

Department of Critical Care Medicine.

Background: Patients with septic shock in whom Norepinephrine (NE) infusion alone is insufficient to raise blood pressure require the concomitant administration of Vasopressin (VP). However, current guidelines do not advise clinicians as to which vasoactive agent to discontinue first once the patient's septic shock begins to resolve. Moreover, there is controversial data guiding clinicians on how to discontinue vasopressors for septic shock patients who are receiving a combination therapy of NE and VP. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001345DOI Listing
April 2019
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Central changes in the Kv10.2 potassium channel in stress-induced hypertension rats.

Neuroreport 2019 Apr 18. Epub 2019 Apr 18.

School of Life Sciences, Shanghai University.

Ion channels play as a pivotal role in hypertension in the processes of maintenance of vascular tone and sympathetic excitement of hypertension. The Kv10.2 channel (encoded by the Kcnh5 gene) belongs to the EAG voltage-gated superfamily. Read More

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http://dx.doi.org/10.1097/WNR.0000000000001244DOI Listing

Comparison of risk scores and shock index in hemodynamically stable patients presenting to the emergency department with nonvariceal upper gastrointestinal bleeding.

Eur J Gastroenterol Hepatol 2019 Apr 18. Epub 2019 Apr 18.

Department of Emergency Medicine, Asan Medical Center, College of Medicine, University of Ulsan.

Objective: Risk assessment in nonvariceal upper gastrointestinal bleeding (UGIB) is not well validated and remains unclear in hemodynamically stable patients at emergency department admission. We compared the prognostic value of risk-scoring systems for predicting adverse outcomes in patients with nonvariceal UGIB and normotension.

Participants And Methods: A single-center prospective observational study was carried out. Read More

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http://dx.doi.org/10.1097/MEG.0000000000001422DOI Listing

Cell-Penetrating Peptide-Mediated Transformation of Large Plasmid DNA into Escherichia coli.

ACS Synth Biol 2019 Apr 22. Epub 2019 Apr 22.

Biomacromolecules Research Team , RIKEN Center for Sustainable Resource Science , 2-1 Hirosawa , Wako-shi , Saitama 351-0198 , Japan.

The highly efficient genetic transformation of cells is essential for synthetic biology procedures, especially for the transformation of large gene clusters. In this technical note, we present a novel cell-penetrating peptide (CPP)-mediated large-sized plasmid DNA transformation system for Escherichia coli. A large plasmid (pMSR227, 205 kb) was complexed with cationic peptides containing a CPP motif and was successfully transformed into E. Read More

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http://dx.doi.org/10.1021/acssynbio.9b00055DOI Listing
April 2019
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[S100 calcium binding protein A16 promotes fat synthesis through endoplasmic reticulum stress in HepG2 cells].

Sheng Li Xue Bao 2019 Apr;71(2):279-286

Department of Geratology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.

The aim of this study was to investigate the role of S100 calcium binding protein A16 (S100A16) in lipid metabolism in hepatocytes and its possible biological mechanism. HepG2 cells (human hepatoma cell line) were cultured with fatty acid to establish fatty acid culture model. The control model was cultured without fatty acid. Read More

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Ventricular Septal Defect Complicating Inferior Acute Myocardial Infarction: A Case of Percutaneous Closure.

J Cardiovasc Echogr 2019 Jan-Mar;29(1):17-19

Heart Department, University Hospital "S.Giovanni di Dio e Ruggi D'Aragona", Salerno, Italy.

Ventricular septal defect (VSD) is one of the most serious mechanical complications of acute myocardial infarction (AMI). Despite the incidence of post-AMI VSD in reperfusion era has reduced from 1%-2% to 0.17%-0. Read More

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http://dx.doi.org/10.4103/jcecho.jcecho_60_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450237PMC