15,648 results match your criteria Shock Hemorrhagic


Dengue virus nonstructural protein 1 activates platelets via Toll-like receptor 4, leading to thrombocytopenia and hemorrhage.

PLoS Pathog 2019 Apr 22;15(4):e1007625. Epub 2019 Apr 22.

Department of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

Dengue virus (DENV) infection, the most common mosquito-transmitted viral infection, can cause a range of diseases from self-limiting dengue fever to life-threatening dengue hemorrhagic fever and shock syndrome. Thrombocytopenia is a major characteristic observed in both mild and severe dengue disease and is significantly correlated with the progression of dengue severity. Previous studies have shown that DENV nonstructural protein 1 (NS1), which can be secreted into patients' blood, can stimulate immune cells via Toll-like receptor 4 (TLR4) and can cause endothelial leakage. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.ppat.1007625DOI Listing

Anti-interferon-α receptor 1 antibodies attenuate inflammation and organ injury following hemorrhagic shock.

J Trauma Acute Care Surg 2019 May;86(5):881-890

From the Elmezzi Graduate School of Molecular Medicine, (J.C., W-L.Y., P.W.); Center for Immunology and Inflammation, (J.C., W-L.Y., Z.W., P.W.) The Feinstein Institute for Medical Research, Manhasset; Department of Surgery, Zucker School of Medicine at Hofstra/Northwell, (W-L.Y., J.T.M., P.W.) Hempstead, New York.

Background: Hemorrhagic shock (HS) is a life-threatening condition resulting from rapid and significant loss of intravascular volume, leading to hemodynamic instability and death. Inflammation contributes to the multiple organ injury in HS. Type I interferons (IFNs), such as IFN-α and IFN-β, are a family of cytokines that regulate the inflammatory response through binding to IFN-α receptor (IFNAR) which consists of IFNAR1 and IFNAR2 chains. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/TA.0000000000002214DOI Listing

Vitamin K deficiency-induced hemorrhagic shock after thoracentesis: a case report.

BMC Gastroenterol 2019 Apr 18;19(1):58. Epub 2019 Apr 18.

Honjoudaiichi Hospital, 110, Iwabuchishita, Yurihonnjou, Akita, 015-8567, Japan.

Background: Vitamin K deficiency results in serious coagulation dysfunction, but hemorrhagic shock is rare. Herein, we describe a case of vitamin K deficiency and abnormality in the path of the intercostal artery, the combination of which led to hemorrhagic shock.

Case Presentation: An 83-year-old woman was hospitalized for suspected gallstones. Read More

View Article

Download full-text PDF

Source
https://bmcgastroenterol.biomedcentral.com/articles/10.1186/
Publisher Site
http://dx.doi.org/10.1186/s12876-019-0978-0DOI Listing
April 2019
1 Read

Tudca Ameliorates Liver Injury Via Activation of SIRT1-FXR Signaling in a Rat Hemorrhagic Shock Model.

Shock 2019 Apr 14. Epub 2019 Apr 14.

Department of Emergency, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Objective: To investigate the changes of bile acids in the liver during hemorrhagic shock (HS) and their potential to attenuate liver injury via activation of SIRT1 (sirtuin 1)-FXR (farnesoid X receptor) signaling.

Methods: A Sprague-Dawley (SD) rat HS model was established, while HepG2 cells were hypoxically cultured to simulate HS in vitro. Liver bile acids (BA) were profiled with ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/SHK.0000000000001351DOI Listing

Prehospital Blood Product and Crystalloid Resuscitation in the Severely Injured Patient: A Secondary Analysis of the Prehospital Air Medical Plasma Trial.

Ann Surg 2019 Apr 13. Epub 2019 Apr 13.

Division of General Surgery and Trauma, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA.

MINI: Hemorrhage is the primary cause of preventable trauma death. Secondary analyses of scene patients from the PAMPer trial demonstrated that prehospital packed red blood cell and plasma had the greatest reduction in 30-day mortality compared with crystalloid-only resuscitation. Patients with hemorrhagic shock should receive prehospital blood products when available, preferably packed red blood cell and plasma. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/SLA.0000000000003324DOI Listing

Posterior Reversible Encephalopathy Syndrome and Reversible Cerebral Vasoconstriction Syndrome after Rapid Blood Transfusion.

Intern Med 2019 Apr 17. Epub 2019 Apr 17.

Department of Neurology, Nissan Tamagawa Hospital, Japan.

We herein report a case of posterior reversible encephalopathy syndrome (PRES) and reversible cerebral vasoconstriction syndrome (RCVS) that occurred immediately after blood transfusion. A 64-year-old Japanese woman was diagnosed with liver cirrhosis due to hepatitis B 2 years ago. She was admitted to our hospital with hemorrhagic shock due to esophageal variceal rupture. Read More

View Article

Download full-text PDF

Source
https://www.jstage.jst.go.jp/article/internalmedicine/advpub
Publisher Site
http://dx.doi.org/10.2169/internalmedicine.1768-18DOI Listing
April 2019
1 Read

Penehyclidine hydrochloride exerts protective effects in rats with acute lung injury via the Fas/FasL signaling pathway.

Exp Ther Med 2019 May 4;17(5):3598-3606. Epub 2019 Mar 4.

Department of Anesthesiology and Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, P.R. China.

Acute lung injury (ALI) is a critical syndrome that is associated with high morbidity and mortality rates. The activation of the Fas/Fas ligand (FasL) signaling pathway may be an important pathophysiological mechanism during ALI development. Penehyclidine hydrochloride (PHC) has been revealed to exhibit anti-apoptotic properties and may attenuate the observed systemic inflammatory response. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/etm.2019.7340DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447765PMC
May 2019
1 Read

Therapeutic effect of carbon monoxide-releasing molecule-3 on acute lung injury after hemorrhagic shock and resuscitation.

Exp Ther Med 2019 May 13;17(5):3429-3440. Epub 2019 Mar 13.

Department of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan.

Hemorrhagic shock and resuscitation (HSR) induces a pulmonary inflammatory response and frequently causes acute lung injury. Carbon monoxide-releasing molecule-3 (CORM-3) has been reported to liberate and deliver CO under physiological conditions, which exerts organ-protective effects during systemic insults. The present study aimed to determine whether the administration of CORM-3 following HSR exerts a therapeutic effect against HSR-induced lung injury without any detrimental effects on oxygenation and hemodynamics. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/etm.2019.7390DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447800PMC
May 2019
1 Read

Trauma-Induced Coagulopathy: The Past, Present, and Future.

J Thromb Haemost 2019 Apr 15. Epub 2019 Apr 15.

Department of Surgery, Denver Health Medical Center and the University of Colorado, 777 Bannock Street. Mail Code 0206, Denver, CO, 80203.

Trauma remains a leading cause of death worldwide, and most early preventable deaths in both the civilian and military settings are due to uncontrolled hemorrhage, despite paradigm advances in modern trauma care. Combined tissue injury and shock result in hemostatic failure, which has been identified as a multi-dimensional molecular, physiologic, and clinical disorder termed trauma-induced coagulopathy (TIC). Understanding the biology of TIC is of utmost importance as it is often responsible for uncontrolled bleeding, organ failure, thromboembolic complications, and death. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jth.14450DOI Listing
April 2019
2 Reads

Pituitary Adenylate Cyclase-Activating Polypeptides Prevent Hepatocyte Damage by Promoting Yes-associated Protein in Liver Ischemia/Reperfusion Injury.

Transplantation 2019 Apr 8. Epub 2019 Apr 8.

Dumont-UCLA Transplant Center, Division of Liver and Pancreas Transplantation, Department of Surgery, David Geffen School of Medicine at University of California-Los Angeles, Los Angeles, CA, USA.

Background: Hepatic ischemia-reperfusion injury (IRI) is a severe complication in liver transplantation, hepatectomy and hemorrhagic shock. As neuropeptides transmit the regulatory signal between nervous-immune systems communication, our previous study documented that pituitary adenylate cyclase-activating polypeptides (PACAP) depressed hepatic TLR4 immune response in liver IRI.

Methods: Here, we focused on how PACAP suppressed hepatocellular damage and enhanced hepatocyte regeneration in a murine model of partial liver warm IRI. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/TP.0000000000002742DOI Listing
April 2019
1 Read

Pre-hospital adenosine, lidocaine and magnesium has inferior survival compared to tactical combat casualty care resuscitation in a porcine model of prolonged hemorrhagic shock.

J Trauma Acute Care Surg 2019 Apr 12. Epub 2019 Apr 12.

Naval Medical Research Unit San Antonio, JBSA-Ft. Sam Houston, TX.

Background: Adenosine, lidocaine, and magnesium (ALM) is a cardioplegic agent shown to improve survival by improving cardiac function, tissue perfusion, and coagulopathy in animal models of shock. We hypothesized pre-hospital ALM treatment in hemorrhagic shock would improve survival compared to current Tactical Combat Casualty Care (TCCC) resuscitation beyond the Golden Hour.

Methods: Swine were randomized to: 1) TCCC, 2) 2cc/kg vehicle control (VC), 3) 2cc/kg ALM+drip, 4) 4cc/kg ALM+drip, 5) 4cc/kg ALM+delayed drip at 0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/TA.0000000000002308DOI Listing
April 2019
2 Reads

Effect of leukoreduction and pathogen reduction on the hemostatic function of whole blood.

Transfusion 2019 Apr;59(S2):1539-1548

Department of Pediatrics, Division of Pediatric Critical Care Medicine, Washington University School of Medicine, St. Louis, Missouri.

Background: There is renewed interest in the use of whole blood (WB) for resuscitation of patients in hemorrhagic shock. Leukoreduction with platelet-sparing filters and pathogen reduction may be used to improve the safety profile of WB, yet the effects of leukoreduction and pathogen reduction on WB hemostatic function are not well characterized.

Study Design And Methods: Blood from 32 healthy group O donors was divided into treatment groups (n = 8 for each group): untreated, pathogen reduced (PR ), leukoreduced using an in-line filter (LR ), or PR LR . Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/trf.15175
Publisher Site
http://dx.doi.org/10.1111/trf.15175DOI Listing
April 2019
2 Reads

Current state of transfusion in traumatic brain injury and associated coagulopathy.

Transfusion 2019 Apr;59(S2):1522-1528

Bloodworks Research Institute, Seattle, Washington.

Traumatic brain injury (TBI)-induced coagulopathy has long been recognized as a significant risk for poor outcomes in patients with TBI, but its pathogenesis remains poorly understood. As a result, current treatment options for the condition are limited and ineffective. The lack of information is most significant for the impact of blood transfusions on patients with isolated TBI and in the absence of confounding influences from trauma to the body and limbs and the resultant hemorrhagic shock. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/trf.15169
Publisher Site
http://dx.doi.org/10.1111/trf.15169DOI Listing
April 2019
5 Reads

Outcomes of traumatic hemorrhagic shock and the epidemiology of preventable death from injury.

Transfusion 2019 Apr;59(S2):1423-1428

Joint Trauma System, U.S. Army Institute of Surgical Research, Fort Sam Houston, Texas.

The majority of potentially preventable deaths after trauma are related to hemorrhage and occur early after injury, with the largest number of deaths occurring before hospital arrival. Approximately one-fourth of trauma deaths may be potentially preventable through early medical and surgical interventions. Interventions dedicated to bleeding control and hemostatic resuscitation have demonstrated merit in decreasing hemorrhagic injury mortality. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/trf.15161DOI Listing
April 2019
1 Read

The need for dried plasma - a national issue.

Transfusion 2019 Apr;59(S2):1587-1592

US Army Medical Research and Materiel Command, Fort Detrick, Maryland.

Recent studies have demonstrated that early transfusion of plasma or RBCs improves survival in patients with severe trauma and hemorrhagic shock. Time to initiate transfusion is the critical factor. It is essential that transfusion begin in the prehospital environment when transport times are longer than approximately 15 to 20 minutes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/trf.15261DOI Listing
April 2019
1 Read

Efficiency of a pelvic circumferential compression device for continuous hemorrhage of peripheral soft tissue of the pelvis: A case report.

Trauma Case Rep 2019 Jun 22;21:100183. Epub 2019 Mar 22.

Department of Hand Surgery, Nagoya University Graduate School of Medicine, Japan.

Background: A pelvic circumferential compression device (PCCD) is a belt that is wrapped around a fractured pelvis and tightened with a closing mechanism. The SAM Sling® is one of the most common PCCDs used for trauma management. Although the use of the SAM Sling® for reduction and stabilization of unstable pelvic ring fracture has become the standard of care in most relevant trauma scenarios, it is not usually used for stopping continuous hemorrhage of the peripheral soft tissue of the pelvis without unstable pelvic ring fractures. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tcr.2019.100183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434492PMC
June 2019
1 Read

The Tsukui (Japan) Yamayuri-en Facility Stabbing Mass-Casualty Incident.

Prehosp Disaster Med 2019 Apr 8:1-6. Epub 2019 Apr 8.

1.Department of Emergency and Critical Care Medicine,Kitasato University School of Medicine,Sagamihara, Kanagawa,Japan.

Introduction: In July 2016, a mass-casualty stabbing attack took place at a facility for disabled persons located in Sagamihara City (Kanagawa Prefecture, Japan). The attack resulted in 45 casualties, including 19 deaths. The study hospital dispatched physicians to the field and admitted multiple casualties. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1017/S1049023X19000128DOI Listing
April 2019
3 Reads

Traumatic injury pattern is of equal relevance as injury severity for experimental (poly)trauma modeling.

Sci Rep 2019 Apr 5;9(1):5706. Epub 2019 Apr 5.

Trauma Department, Hannover Medical School, Hannover, Germany.

This study aims to elaborate the relevance of trauma severity and traumatic injury pattern in different multiple and/or polytrauma models by comparing five singular trauma to two different polytrauma (PT) models with high and one multiple trauma (MT) model with low injury-severity score (ISS). The aim is to provide a baseline for reducing animal harm according to 3Rs by providing less injury as possible in polytrauma modeling. Mice were randomly assigned to 10 groups: controls (Ctrl; n = 15), Sham (n = 15); monotrauma groups: hemorrhagic shock (HS; n = 15), thoracic trauma (TxT; n = 18), osteotomy with external fixation (Fx; n = 16), bilateral soft tissue trauma (bSTT; n = 16) or laparotomy (Lap; n = 16); two PT groups: PT I (TxT + HS + Fx; ISS = 18; n = 18), PT II (TxT + HS + Fx + Lap; ISS = 22; n = 18), and a MT group (TxT + HS + bSTT + Lap, ISS = 13; n = 18). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-019-42085-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450898PMC
April 2019
1 Read

Targeting Complement Pathways in Polytrauma- and Sepsis-Induced Multiple-Organ Dysfunction.

Front Immunol 2019 21;10:543. Epub 2019 Mar 21.

Institute for Clinical and Experimental Trauma-Immunology, University Hospital of Ulm, Ulm, Germany.

Exposure to traumatic or infectious insults results in a rapid activation of the complement cascade as major fluid defense system of innate immunity. The complement system acts as a master alarm system during the molecular danger response after trauma and significantly contributes to the clearance of DAMPs and PAMPs. However, depending on the origin and extent of the damaged macro- and micro -milieu, the complement system can also be either excessively activated or inhibited. Read More

View Article

Download full-text PDF

Source
https://www.frontiersin.org/article/10.3389/fimmu.2019.00543
Publisher Site
http://dx.doi.org/10.3389/fimmu.2019.00543DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437067PMC
March 2019
4 Reads

Location is the key to function: HMGB1 in sepsis and trauma-induced inflammation.

J Leukoc Biol 2019 Apr 4. Epub 2019 Apr 4.

Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

High mobility group box 1 (HMGB1) is a multifunctional nuclear protein, probably known best as a prototypical alarmin or damage-associated molecular pattern (DAMP) molecule when released from cells. However, HMGB1 has multiple functions that depend on its location in the nucleus, in the cytosol, or extracellularly after either active release from cells, or passive release upon lytic cell death. Movement of HMGB1 between cellular compartments is a dynamic process induced by a variety of cell stresses and disease processes, including sepsis, trauma, and hemorrhagic shock. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/JLB.3MIR1218-497RDOI Listing
April 2019
2 Reads

Influenza A with hemorrhagic shock and encephalopathy syndrome in an adult: A case report.

Medicine (Baltimore) 2019 Apr;98(14):e15012

Department of Emergency and Acute Intensive Care Medicine, Kurume University School of Medicine, Fukuoka, Japan.

Introduction: Hemorrhagic shock and encephalopathy syndrome (HSES) is a type of acute encephalopathy mainly seen in infants. It is a syndrome encompassing an onset of high fever, disturbance of consciousness, convulsion, and shock that rapidly progresses to watery diarrhea and liver and renal dysfunctions. It is extremely rare in adults, and the number of reports is limited worldwide. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000015012DOI Listing
April 2019
8 Reads

Prehospital whole blood resuscitation prevents coagulopathy and improves acid-base status at hospital arrival in a nonhuman primate hemorrhagic shock model.

Transfusion 2019 Apr 3. Epub 2019 Apr 3.

Naval Medical Research Unit San Antonio, JBSA-Ft. Sam Houston, Texas.

Background: Hemorrhage remains the primary cause of preventable death in civilian and military trauma. The Committee on Tactical Combat Casualty Care recommends prehospital (PH) resuscitation with whole blood (WB). However, 6% hetastarch in lactated electrolyte (HEX) and crystalloids are more commonly available and used for PH resuscitation in military and civilian environments, respectively. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/trf.15294DOI Listing
April 2019
1 Read

Pathophysiological significance of clock genes BMAL1 and PER2 as erythropoietin-controlling factors in acute blood hemorrhage.

Hum Cell 2019 Apr 2. Epub 2019 Apr 2.

Department of Legal Medicine, Osaka City University Medical School, Asahi-Machi 1-4-3, Abeno, Osaka, 545-8585, Japan.

This study aimed to characterize the pathophysiology, including possible correlations, of clock gene expression and erythropoietin (EPO) production in the acute stage of blood hemorrhage. Specimens of human cortical tissues (right and left kidneys) and cardiac blood were collected at autopsy from 52 cases following mortality due to acute-stage blood hemorrhage following sharp instrument injury. BMAL1 and PER2 mRNA levels were determined by reverse transcription-polymerase chain reaction; BMAL1 and PER2 protein levels were assessed using immunohistochemistry; BMAL1 protein levels were quantitatively measured by western blotting; and serum EPO levels were measured by chemiluminescent enzyme immunoassay. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s13577-019-00248-2
Publisher Site
http://dx.doi.org/10.1007/s13577-019-00248-2DOI Listing
April 2019
3 Reads

Essentials of Emergency Transfusion - the Complement to Stop the Bleed.

J Trauma Acute Care Surg 2019 Apr 1. Epub 2019 Apr 1.

Division of Trauma and Surgical Critical Care, Department of Surgery, LAC+USC Medical Center, University of Southern California, Los Angeles, CA 90033, USA.

Over the past decade, the shift toward damage control surgery for bleeding trauma patients has come with an increased emphasis on optimal resuscitation. Two life-saving priorities predominate: to quickly stop the bleed and effectively resuscitate the hemorrhagic shock. Blood is separated into components for efficient storage and distribution; however, bleeding patients require all components in a balanced ratio. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/TA.0000000000002298DOI Listing
April 2019
3 Reads

The hollow adrenal gland sign: a newly described enhancing pattern of the adrenal gland on dual-phase contrast-enhanced CT for predicting the prognosis of patients with septic shock.

Eur Radiol 2019 Apr 1. Epub 2019 Apr 1.

Department of Radiology, The First Affiliated Hospital of Sun Yat-Sen University, No.58 Zhongshanerlu Road, Guangzhou, Guangdong, People's Republic of China.

Objective: To investigate the incidence, CT appearance, and implication for prognosis of the hollow adrenal gland sign (HAGS).

Methods: A total of 194 patients with septic shock and 24 patients with hemorrhagic shock (as control group) were retrospectively included in this study and the patients with septic shock were further divided into four subgroups (digestive tract diseases, DTD, n = 49; biliary and pancreatic diseases, BPD, n = 41; postsurgical infection, PI, n = 64; and other diseases, OD, n = 40). All patients underwent a dual-phase contrast-enhanced CT within 1 week after diagnosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00330-019-06172-1DOI Listing
April 2019
5 Reads

Fatal Exsanguination Following Rupture of an Iliac Artery Aneurysm in an Infant With Menkes Disease.

Pediatr Dev Pathol 2019 Apr 1:1093526619841152. Epub 2019 Apr 1.

1 Department of Paediatric Surgery, John Hunter Children's Hospital, Newcastle, Australia.

Menkes disease (MD) usually presents in infancy with respiratory and neurological complications. Severe isolated vasculo-connective tissue involvement in infancy is rare, and hence the precise and timely diagnosis is difficult. We report a case of an 8-week-old male infant who succumbed to acute, severe exsanguination, and hemorrhagic shock secondary to a large retroperitoneal hematoma due to rupture of a right iliac artery aneurysm. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1093526619841152DOI Listing
April 2019
1 Read

3-Trifluoromethylpyrazolones derived nucleosides: Synthesis and antiviral evaluation.

Nucleosides Nucleotides Nucleic Acids 2019 Mar 31:1-14. Epub 2019 Mar 31.

a Applied Nucleic Acids Research Center , Zagazig University , Zagazig , Egypt.

Dengue (DENV) viral infection is a global public health problem that infrequently develops life threatening diseases such as dengue hemorrhagic fever (DFS) and dengue shock syndrome (DSS). Middle East respiratory syndrome coronavirus (MERS-CoV) is a highly pathogenic human corona virus with 38% fatality rate of infected patients. A series of 4-arylhydrazono-5-trifluoromethyl-pyrazolones, their ribofuranosyl, and 5'-deoxyribofuranosyl nucleosides were synthesized, geometry optimized using Density functional theory (DFT), and evaluated for their antiviral activity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/15257770.2019.1591445DOI Listing
March 2019
1 Read

Uretero-iliac artery fistula: a challenge diagnosis for a life-threatening condition: monocentric experience and review of the literature.

Int Urol Nephrol 2019 Mar 30. Epub 2019 Mar 30.

Clinica Urologica, Ospedali Riuniti, Università Politecnica delle Marche, Ancona, Italy.

Introduction: Uretero-iliac artery fistulae (UIAF) are the consequence of chronic inflammatory events that create a fibrous and poorly vascularized uretero-vascular adhesion. They often occur in patients with a history of surgery, pelvic radiotherapy, and chronic ureteral stenting. The presentation is usually massive gross hematuria with acute anemia unto to hemorrhagic shock, representing a life-threatening condition. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11255-019-02097-2DOI Listing
March 2019
2 Reads
1.293 Impact Factor

The utility of resuscitative endovascular balloon occlusion of the aorta for temporary hemostasis after extensive bilateral lower extremity injuries: A case report.

Radiol Case Rep 2019 May 15;14(5):623-626. Epub 2019 Mar 15.

Department of Emergency and Critical Care Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi-ken, 329-0498 Japan.

A 75-year-old pedestrian was struck by a truck and in shock with both lower extremities significantly deformed, with injuries extending proximally to the inguinal region and degloving injuries. Resuscitative endovascular balloon occlusion of the aorta was performed to achieve temporary hemostasis and the patient became hemodynamically stable. Following stabilization, both lower extremities were amputated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.radcr.2019.03.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423353PMC
May 2019
1 Read

Zones matter: Hemodynamic effects of zone 1 vs zone 3 resuscitative endovascular balloon occlusion of the aorta placement in trauma patients.

Injury 2019 Mar 12. Epub 2019 Mar 12.

R Adams Cowley Shock Trauma Center, University of Maryland, Baltimore, MD, United States.

Introduction: Resuscitative endovascular balloon occlusion of the aorta (REBOA) has emerged as a therapy for hemorrhagic shock to limit ongoing bleeding and support proximal arterial pressures. Current REBOA algorithms recommend zone selection based on suspected anatomic location of injury rather than severity of shock. We examined the effects of Zone 1 versus Zone 3 REBOA in patients enrolled in the American Association for the Surgery of Trauma Aortic Occlusion for Resuscitation in Trauma and Acute Care Surgery (AORTA) Registry. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.injury.2019.03.013DOI Listing
March 2019
2 Reads

Successful laparoscopic management of diaphragmatic pregnancy:a rare case report and brief review of literature.

BMC Pregnancy Childbirth 2019 Mar 28;19(1):99. Epub 2019 Mar 28.

Departments of Gynecology, Zhejiang Provincial People's Hospital, People's Hospital Of Hangzhou Medical College, No. 158 Shangtang Rd, Hangzhou, 310014, People's Republic of China.

Background: Abdominal ectopic pregnancies are rare category of ectopic pregnancies.We describe a ectopic pregnancy implanted on the surface of diaphragm and highlight the difficult clinical course of an abdominal ectopic pregnancy managed with strategic procedural intervention.

Case Presentation: A 33-year-old Chinese woman with abdominal pain was diagnosed with ectopic pregnancy implanted in the liver according to CT and advised to transfer the patient to tertiary referral center. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12884-019-2248-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438013PMC
March 2019
1 Read

School Nurses on the Front Lines of Medicine: The Approach to a Student With Severe Traumatic Bleeding.

NASN Sch Nurse 2019 Mar 28:1942602X19837525. Epub 2019 Mar 28.

Professor, Departments of Emergency Medicine and Pediatrics, Penn State College of Medicine,Attending Pediatric Emergency Medicine Physician, Penn State Hershey Medical Center, Hershey, PA.

With the continued threat of mass casualty incidents in schools and surrounding communities, it is essential for school nurses to be knowledgeable regarding the recognition of hemorrhagic shock due to massive bleeding and the acute management of these victims. In the past decade, increased interest and research in acute bleeding control have led to published evidence-based guidelines to reduce morbidity and mortality for victims of violent acts. It is essential that healthcare providers, including nurses who are the first responders in schools, are aware of methods to assess and control massive bleeding. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1942602X19837525DOI Listing

Time to epinephrine treatment is associated with the risk of mortality in children who achieve sustained ROSC after traumatic out-of-hospital cardiac arrest.

Crit Care 2019 Mar 27;23(1):101. Epub 2019 Mar 27.

Department of Emergency Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, No. 123, Dapi Rd., Niaosong Dist., Kaohsiung, 833, Taiwan.

Background: The benefits of early epinephrine administration in pediatric with nontraumatic out-of-hospital cardiac arrest (OHCA) have been reported; however, the effects in pediatric cases of traumatic OHCA are unclear. Since the volume-related pharmacokinetics of early epinephrine may differ obviously with and without hemorrhagic shock (HS), beneficial or harmful effects of nonselective epinephrine stimulation (alpha and beta agonists) may also be enhanced with early administration. In this study, we aimed to analyze the therapeutic effect of early epinephrine administration in pediatric cases of HS and non-HS traumatic OHCA. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13054-019-2391-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437972PMC
March 2019
1 Read

Whole Blood in Trauma: A Review for Emergency Clinicians.

J Emerg Med 2019 Mar 20. Epub 2019 Mar 20.

San Antonio Fire Department EMS, San Antonio, Texas; Department of Emergency Health Sciences, University of Texas Health San Antonio, San Antonio, Texas.

Background: Blood products are a cornerstone of trauma resuscitation. From the historically distant battlefields of World War II through present-day conflict around the globe, whole blood (WB) has been a potent tool in the treatment of massive hemorrhagic shock. Component therapy with a targeted ratio of packed red blood cells, platelets, and plasma has previously been utilized. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S07364679193003
Publisher Site
http://dx.doi.org/10.1016/j.jemermed.2019.01.024DOI Listing
March 2019
11 Reads

Computer simulation of transfusion with different blood product ratios in modern massive transfusion protocols.

Med Hypotheses 2019 Apr 2;125:10-15. Epub 2019 Feb 2.

Department of Anesthesiology and Perioperative Medicine, Queen's University, Kingston K7L 2V7, Ontario, Canada. Electronic address:

Modern massive transfusion protocols call for early plasma and platelets to patients presenting with hemorrhagic shock. The packed red blood cell (PRBC):plasma:platelet ratio generally ranges from 1:1:1 to 3:1:1, but the ideal ratio remains controversial. We aimed to determine the effects of different resuscitation strategies and blood product ratios on hematocrit, platelet and fibrinogen concentrations (FC) during resuscitation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mehy.2019.02.004DOI Listing
April 2019
1 Read

Trauma ICU Prevalence Project: the diversity of surgical critical care.

Trauma Surg Acute Care Open 2019 18;4(1):e000288. Epub 2019 Feb 18.

Surgery, Inova Fairfax Medical Campus, Falls Church, Virginia, USA.

Background: Surgical critical care is crucial to the care of trauma and surgical patients. This study was designed to provide a contemporary assessment of patient types, injuries, and conditions in intensive care units (ICU) caring for trauma patients.

Methods: This was a multicenter prevalence study of the American Association for the Surgery of Trauma; data were collected on all patients present in participating centers' trauma ICU (TICU) on November 2, 2017 and April 10, 2018. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/tsaco-2018-000288DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407564PMC
February 2019
2 Reads

A Smartphone Video Transmission System for Verification of Transfusion.

Air Med J 2019 Mar - Apr;38(2):125-128. Epub 2019 Jan 15.

Department of Acute Critical Care Medicine, Juntendo University Shizuoka Hospital, Shizuoka, Japan.

A physician-staffed helicopter emergency medical service called a doctor helicopter (DH) in Eastern Shizuoka was equipped with a smartphone video transmission system in April 2018. We herein report on the introduction of this system for the verification of transfusion in the DH. A 51-year-old man visited a local hospital after cutting his left neck himself. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.amj.2018.11.012DOI Listing
January 2019
2 Reads

Life-Threatening Complications of Atrial Fibrillation Ablation: 16-Year Experience in a Large Prospective Tertiary Care Cohort.

JACC Clin Electrophysiol 2019 Mar 30;5(3):284-291. Epub 2019 Jan 30.

Sydell and Arnold Miller Family Heart and Vascular Institute, Robert and Suzanne Tomsich Department of Cardiovascular Medicine, Section of Cardiac Pacing and Electrophysiology, Cleveland Clinic Foundation, Cleveland, Ohio. Electronic address:

Objectives: This study sought to assess the incidence and outcomes of life-threatening complications from atrial fibrillation ablations in a high volume center.

Background: With increasing rates of atrial fibrillation ablation procedures, an increase in life-threatening procedure-related complications has been reported despite improvements in technology and ablation strategies.

Methods: Between 2000 and 2015, 10,378 patients underwent atrial fibrillation ablation at our institution and were enrolled in a prospectively maintained data registry. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jacep.2018.11.013DOI Listing
March 2019
1 Read

Characteristic Changes and 3D Virtual Measurement of Lung CT Image Parameters in the Drowning Rabbit Model.

Fa Yi Xue Za Zhi 2019 Feb 25;35(1):1-4. Epub 2019 Feb 25.

Shanghai Key Laboratory of Forensic Medicine, Shanghai Forensic Service Platform, Academy of Forensic Science, Shanghai 200063, China.

Objectives: To use virtual anatomy technique in the analysis of post-mortem characteristic changes of CT images in the experimental drowning rabbit model and the related parameters in 3D virtual model, so as to explore its application value in the diagnosis of drowning in forensic pathology.

Methods: A model of drowning rabbits was established, with animal models of hemorrhagic shock and mechanical asphyxia as the controls. CT scan was performed on the experimental animals, and the differences in imaging features between the groups were compared by morphological reading of the tomographic images. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12116/j.issn.1004-5619.2019.01.001DOI Listing
February 2019
1 Read

Liver Tissue-related Metabolic Mechanism of Different Infusion Volumes for Hemorrhagic Shock.

Fa Yi Xue Za Zhi 2018 Jun 25;34(6):625-630. Epub 2018 Dec 25.

Department of Forensic Pathology, Medical College, Shantou University, Shantou 515041, Guangdong Province, China.

Objectives: To investigate the curative effects of various infusion volumes on liver-related metabolic mechanism in the treatment of hemorrhagic shock.

Methods: A severe hemorrhagic shock rabbit model was established in 30 rabbits. The rabbits were randomly divided into three groups: non-infusion group (A), conventional infusion group (B), and excessive infusion group (C) (n=10 in each group). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12116/j.issn.1004-5619.2018.06.010DOI Listing
June 2018
1 Read

A Quantitative Study of the Dimensional Change of Inferior Vena Cava on Computed Tomography During Acute Hemorrhage Shock in Swine.

J Invest Surg 2019 Mar 20:1-8. Epub 2019 Mar 20.

a Trauma Center of PLA, State Key Laboratory of Trauma, Burns and Combined Injury , Institute of Surgery Research, Daping Hospital, Army Medical University , Chongqing , China.

Background: The purpose of this study was to examine the dimensional change of IVC during acute hemorrhage through a volume-controlled acute hemorrhagic shock model in swine.

Methods: Volume-controlled hemorrhage was performed in 10 adult Bama mini pigs. Enhanced CT scan and hemodynamic monitoring were performed when the cumulative blood loss volume reached 0%, 10%, 20%, 30%, and 40%. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/08941939.2019.1567873DOI Listing
March 2019
1 Read
1.191 Impact Factor

Evaluation of tissue oxygen saturation in naturally occurring canine shock patients.

J Vet Emerg Crit Care (San Antonio) 2019 Mar 14;29(2):149-153. Epub 2019 Mar 14.

Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, Saint Paul, MN.

Objective: To measure tissue oxygen saturation (StO ) in a population of dogs with naturally occurring shock and to evaluate the relationship of StO with an established veterinary severity scoring system (Acute Patient Physiologic and Laboratory Evaluation) and patient survival.

Design: Prospective observational study.

Setting: University teaching hospital. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/vec.12818DOI Listing
March 2019
2 Reads

Ruptured pancreaticoduodenal artery aneurysm presenting with duodenal obstruction.

Radiol Case Rep 2019 May 5;14(5):568-571. Epub 2019 Mar 5.

Department of Radiology, Michael E. DeBakey VA Medical Center, Houston, TX, USA.

Visceral aneurysms of the pancreaticoduodenal arcades are rare. Although these aneurysms are often asymptomatic and identified incidentally on cross-sectional imaging, aneurysm rupture presents significant morbidity. Ruptured pancreaticoduodenal arcade aneurysms typically present with abdominal pain, hemorrhagic shock, or gastrointestinal bleeding. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S19300433183033
Publisher Site
http://dx.doi.org/10.1016/j.radcr.2019.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406046PMC
May 2019
6 Reads

Trigeminal Nerve Stimulation: A Novel Method of Resuscitation for Hemorrhagic Shock.

Crit Care Med 2019 Mar 19. Epub 2019 Mar 19.

Department of Neurosurgery, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY.

Objectives: To determine if trigeminal nerve stimulation can ameliorate the consequences of acute blood loss and improve survival after severe hemorrhagic shock.

Design: Animal study.

Setting: University research laboratory. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/CCM.0000000000003735DOI Listing
March 2019
4 Reads

Massive hemoperitoneum and upper gastrointestinal hemorrhage following liver rupture secondary to gallbladder perforation: A case report and literature review.

Medicine (Baltimore) 2019 Mar;98(11):e14729

Department of Liver Surgery & Liver Transplantation Center, West China Hospital of Sichuan University, Chendu, Sichuan.

Rationale: Available literature states that the common reasons for non-traumatic spontaneous liver rupture are hepatocellular carcinoma, macronodular cirrhosis, hemangioma, and other tumors; gallbladder perforation is not cited as a cause.

Patient Concerns: The patient presented with sudden-onset right upper quadrant pain with tarry stool for 3 days after eating with dysphoria and increasing thirst; gradually, hemorrhagic shock developed. He had no history of trauma, no background of chronic hepatitis, and no cirrhosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000014729DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426586PMC
March 2019
1 Read

Ultrasound Diagnosed Rare Partial Nephrectomy Complication.

Int J Angiol 2019 Mar 26;28(1):25-27. Epub 2018 Dec 26.

Department of Cardiology and Angiology, University Hospital Giessen, Giessen, Germany.

Renal artery pseudoaneurysm (RAP) is a serious complication that can lead to severe hematuria, blood loss, and life-threatening hemorrhagic shock. A pseudoaneurysm is defined as an arterial wall deficiency that results in the accumulation of oxygenated blood in the nearby extraluminal region. Partial nephrectomy, a parenchymal sparing method, carries a lower risk of postoperative development of chronic kidney disease than total nephrectomy but a higher risk of iatrogenic vascular lesions such as RAP or arteriovenous fistulas. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/s-0038-1676790DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417895PMC
March 2019
1 Read

Artificial Oxygen Carriers and Red Blood Cell Substitutes: An Historic Overview and Recent Developments Toward Military and Clinical Relevance.

J Trauma Acute Care Surg 2019 Mar 8. Epub 2019 Mar 8.

Trauma Center at Penn, Department of Surgery, University of Pennsylvania, Philadelphia, PA, 19104.

Packed red blood cells are a critical component in the resuscitation of hemorrhagic shock. The availability of donor-derived blood products, however, suffers from issues of supply, immunogenicity, and pathogenic contamination. Deployment in remote or austere environments, such as the battlefield, is further hindered by the inherent perishability of blood products. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/TA.0000000000002250DOI Listing
March 2019
2 Reads

Monotrauma is associated with enhanced remote inflammatory response and organ damage, while polytrauma intensifies both in porcine trauma model.

Eur J Trauma Emerg Surg 2019 Mar 12. Epub 2019 Mar 12.

Department of Trauma, Hand and Reconstructive Surgery, University Hospital of the Goethe-University Frankfurt, 60590, Frankfurt, Germany.

Aim: Severely injured patients experience substantial immunological stress upon traumatic insult. Next to the direct local tissue injury also other organs, which are not directly injured such as liver and lung, are frequently affected by a so-called remote organ damage (ROD) after trauma. Thus, we studied the inflammatory response of lung and liver either after isolated femur fracture as example for ROD, or after multiple trauma in a porcine polytrauma model. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00068-019-01098-1DOI Listing
March 2019
2 Reads

The Prehospital Trauma Registry Experience With Intraosseous Access.

J Spec Oper Med Spring 2019;19(1):52-55

Background: Peripheral intravenous (IV) cannulation is often difficult to obtain in a patient with hemorrhagic shock, delaying the appropriate resuscitation of critically ill patients. Intraosseous (IO) access is an alternative method. To date, few data exist on use of this procedure by ground forces in Afghanistan. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/DOI Listing
March 2019
8 Reads

Salvage of rib stabilization hardware with antibiotic beads.

Am J Surg 2019 Feb 28. Epub 2019 Feb 28.

Division of Trauma, Critical Care, and General Surgery, Mayo Clinic Rochester, Rochester, MN, United States. Electronic address:

Background: Surgical stabilization of rib fractures (SSRF) can be used to improve pulmonary mechanics; however, hardware infection is a morbid complication. Antibiotic impregnated beads have been used to suppress infection in orthopedic practices. We aimed to determine the efficacy of antibiotic beads for infected and at-risk SSRF hardware. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.amjsurg.2019.02.032DOI Listing
February 2019
2 Reads