15,562 results match your criteria Shock Hemorrhagic


Protein Disulfide Isomerase Inhibitor Suppresses Viral Replication and Production during Antibody-Dependent Enhancement of Dengue Virus Infection in Human Monocytic Cells.

Viruses 2019 Feb 13;11(2). Epub 2019 Feb 13.

Division of Molecular Medicine, Research Department, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.

One of several mechanisms that leads to the development of dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS) is called antibody-dependent enhancement (ADE). Monocytes can be infected by the ADE phenomenon, which occurs in dengue secondary infection. This study aimed to investigate the proteins involved in ADE of DENV infection in the human monocytic cell line U937. Read More

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http://dx.doi.org/10.3390/v11020155DOI Listing
February 2019

Multiple hepatic metastases of cardiac angiosarcoma.

Autops Case Rep 2018 Oct-Dec;8(4):e2018048. Epub 2018 Oct 9.

University of Campinas (Unicamp), School of Medical Sciences, Department of Gastroenterology (Gastrocentro). Campinas, SP, Brazil.

The differential diagnosis of hepatic focal lesions is challenging because the etiology can be inflammatory, infectious, and even neoplastic. A rare cause of metastatic liver nodules is cardiac angiosarcoma. We report a case of this tumor, which was diagnosed only after autopsy. Read More

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http://dx.doi.org/10.4322/acr.2018.048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360823PMC
October 2018

Vasopressor Use in Hemorrhagic Shock-What Can Propensity Matching Actually Tell Us?

Crit Care Med 2019 Mar;47(3):e273-e274

GICU, St George's Hospital, Tooting, London, United Kingdom GICU, St George's Hospital, Tooting, London, United Kingdom, and Institute of Medical and Biomedical Education, St George's, University of London, Tooting, London, United Kingdom.

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http://dx.doi.org/10.1097/CCM.0000000000003571DOI Listing

Evaluation of biomarkers of kidney injury following 4% succinylated gelatin and 6% hydroxyethyl starch 130/0.4 administration in a canine hemorrhagic shock model.

J Vet Emerg Crit Care (San Antonio) 2019 Feb 14. Epub 2019 Feb 14.

School of Veterinary and Life Sciences, Murdoch University, Perth, WA, Australia.

Objective: To investigate the association between synthetic colloids and biomarkers of acute kidney injury (AKI) in dogs with hemorrhagic shock.

Design: Experimental interventional study.

Setting: University. Read More

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http://dx.doi.org/10.1111/vec.12814DOI Listing
February 2019
1 Read

Defining massive transfusion in civilian pediatric trauma.

J Pediatr Surg 2019 Jan 31. Epub 2019 Jan 31.

Department of Pediatric Surgery, Texas Children's Hospital and Baylor College of Medicine, Houston, TX. Electronic address:

Purpose: The purpose of this study was to identify an optimal definition of massive transfusion (MT) in civilian pediatric trauma.

Methods: Severely injured children (age ≤18 years, injury severity score ≥25) in the Trauma Quality Improvement Program research datasets 2014-2015 that received blood products were identified. Children with traumatic brain injury and non-survivable injuries were excluded. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2019.01.029DOI Listing
January 2019

Minute-to-minute urine flow rate variability: a retrospective survey of its ability to provide early warning of acute hypotension in critically ill multiple trauma patients.

Eur J Trauma Emerg Surg 2019 Feb 13. Epub 2019 Feb 13.

General Intensive Care Unit, Department of Anesthesiology and Critical Care, Soroka Medical Center, Ben-Gurion University of the Negev, Beersheba, Israel.

Purpose: Dynamic changes in urine output and neurological status are the recognized clinical signs of hemodynamically significant hemorrhage. In the present study, we analyzed the dynamic minute-to-minute changes in the UFR and also the changes in its minute-to-minute variability in a group of critically ill multiple trauma patients whose blood pressures were normal on admission to the ICU but who subsequently developed hypotension within the first few hours of their ICU admission.

Patients And Methods: The study was retrospective and observational. Read More

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http://dx.doi.org/10.1007/s00068-019-01090-9DOI Listing
February 2019

Permissive hypotensive resuscitation in patients with traumatic hemorrhagic shock.

Scand J Trauma Resusc Emerg Med 2019 Feb 12;27(1):14. Epub 2019 Feb 12.

Division of Acute Care Surgery, Department of Critical Care Medicine, Kaohsiung Veterans General Hospital, 386, Da-Chung 1st Road, Kaohsiung City, 813, Taiwan.

We read the article "Risks and benefits of hypotensive resuscitation in patients with traumatic hemorrhagic shock: a meta-analysis" by Natthida Owattanapanich et al. with great interest and found it to be insightful. In our commentary, we propose possible reasons why mortality was lower in the permissive hypotension group and how the need for blood transfusion decreased in this group. Read More

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http://dx.doi.org/10.1186/s13049-019-0595-5DOI Listing
February 2019

Improved Long-term Survival with Remote Limb Ischemic Preconditioning in a Rat Fixed-Pressure Hemorrhagic Shock Model.

Cardiovasc Drugs Ther 2019 Feb 12. Epub 2019 Feb 12.

HMRI Cardiovascular Research Institute, Huntington Medical Research Institutes, 686 S. Fair Oaks Ave., Pasadena, CA, 91105, USA.

Purpose: We investigated whether bilateral, lower limb remote ischemic preconditioning (RIPC) improved long-term survival using a rat model of hemorrhagic shock/resuscitation.

Methods: Rats were anesthetized, intubated and ventilated, and randomly assigned to RIPC, induced by inflating bilateral pressure cuffs around the femoral arteries to 200 mmHg for 5 min, followed by 5-min release of the cuffs (repeated for 4 cycles), or control group (cuffs were inflated to 30 mmHg). Hemorrhagic shock was induced by withdrawing blood to a fixed mean blood pressure of 30 mmHg for 30 min, followed by 30 min of resuscitation with shed blood. Read More

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http://link.springer.com/10.1007/s10557-019-06860-6
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http://dx.doi.org/10.1007/s10557-019-06860-6DOI Listing
February 2019
5 Reads

Prolonged Cold-Ischemia Induces Necroptotic Cell Death in Ischemia Reperfusion Injury and Contributes to Primary Graft Dysfunction After Lung Transplantation.

Am J Respir Cell Mol Biol 2019 Feb 11. Epub 2019 Feb 11.

University of Pittsburgh, Pittsburgh, Pennsylvania, United States.

Primary graft dysfunction (PGD), a major cause of morbidity after lung transplantation, is linked to ischemia-reperfusion injury (IRI). Other factors such as preceding brain death (BD), hemorrhagic shock (HS), and pre-engraftment lung management are also important. We hypothesized that a multi-hit isogenic mouse model of lung transplantation is more closely linked to PGD than IRI alone. Read More

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http://dx.doi.org/10.1165/rcmb.2018-0207OCDOI Listing
February 2019
1 Read

Pre-hospital modified shock index for prediction of massive transfusion and mortality in trauma patients.

Am J Emerg Med 2019 Feb 1. Epub 2019 Feb 1.

Department of Orthopedic Surgery, Pusan National University Hospital, 179, Gudeok-ro, Seo-gu, Busan 602-739, South Korea.

Background: Modified shock index (MSI) is a useful predictor in trauma patients. However, the value of prehospital MSI (preMSI) in trauma patients is unknown. The aim of this study was to investigate the accuracy of preMSI in predicting massive transfusion (MT) and hospital mortality among trauma patients. Read More

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http://dx.doi.org/10.1016/j.ajem.2019.01.056DOI Listing
February 2019
2 Reads

Evidence-Based Clinical Management of Ebola Virus Disease and Epidemic Viral Hemorrhagic Fevers.

Infect Dis Clin North Am 2019 Mar;33(1):247-264

Interdepartmental Division of Critical Care, University of Toronto, 209 Victoria Street, 4th Floor, Room 411, Toronto, Ontario M5B 1T8, Canada; Department of Medicine, Université de Sherbrooke, 300112e Avenue Nord, Sherbrooke, Québec J1H 5N4, Canada. Electronic address:

The 2014 to 2016 Ebola virus disease outbreak underscored the threat posed by hemorrhagic fevers. Filoviral outbreaks have been identified since 1967, but data collection has remained sparse, limiting current knowledge of these illnesses. Documentation of objective physical signs and laboratory parameters and appropriate clinical management are connected and interdependent. Read More

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http://dx.doi.org/10.1016/j.idc.2018.10.013DOI Listing

[Beneficial effects of hemoglobin-based oxygen carriers on early resuscitation in rats with uncontrolled hemorrhagic shock].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2019 Jan;31(1):81-86

State Key Laboratory of Trauma, Burn and Combined Injury, Institute of Surgery Research, Daping Hospital of Army Medical University, Chongqing 400042, China. Corresponding author: Li Tao, Email:

Objective: To investigate the early resuscitation effect of hemoglobin-based oxygen carriers (HBOC) in rats with uncontrolled hemorrhagic shock.

Methods: 170 Sprague-Dawley (SD) rats were randomly divided into five groups: lactate Ringer solution (LR) control group, whole blood control group, and 0.5%, 2. Read More

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http://dx.doi.org/10.3760/cma.j.issn.2095-4352.2019.01.016DOI Listing
January 2019
1 Read

[Blockade of programmed death-ligand 1 attenuates indirect acute lung injury in mice through targeting endothelial cells but not epithelial cells].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2019 Jan;31(1):37-43

Department of Internal Emergency Medicine, East Hospital, Tongji University, Shanghai 200120, China. Corresponding author: Xu Shumin, Email:

Objective: To examine the expression profile of programmed death-ligand 1 (PD-L1) on lung endothelial or epithelial cells, and to determine the specific role of PD-L1 in mouse model of indirect acute lung injury (i-ALI).

Methods: Eighty male C57BL/6 mice were randomly divided into two parts (both n = 40). The effects of different administration routes on the expression of PD-L1 were observed. Read More

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http://dx.doi.org/10.3760/cma.j.issn.2095-4352.2019.01.009DOI Listing
January 2019
4 Reads

Association of Appendicitis, Helicobacter Pylori Positive Gastritis and Thrombotic Thrombocytopenic Purpura in an Adolescent.

Am J Case Rep 2019 Jan 31;20:131-133. Epub 2019 Jan 31.

Department of Nephrology, University Hospital in Split, Split, Croatia.

BACKGROUND Thrombotic thrombocytopenic purpura (TTP) in children is a rare life-threatening syndrome, characterized by microangiopathic hemolytic anemia, thrombocytopenia with renal dysfunction, neurologic symptoms, and fever. TTP is usually caused by deficient activity of von Willebrand factor cleaving protease (ADAMTS13), due to either gene mutations or acquired via anti-ADAMTS13 autoantibodies. It can be triggered by bone marrow or solid organ transplantation, cardiothoracic-, abdominal-, and orthopedic surgeries, infections including very rarely Helicobacter pylori infection. Read More

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http://dx.doi.org/10.12659/AJCR.913129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364441PMC
January 2019
2 Reads

Protein -GlcNAcylation in Cardiac Pathologies: Past, Present, Future.

Front Endocrinol (Lausanne) 2018 15;9:819. Epub 2019 Jan 15.

l'institut du thorax, INSERM, CNRS, UNIV Nantes, Nantes, France.

-GlcNAcylation is a ubiquitous and reversible post-translational protein modification that has recently gained renewed interest due to the rapid development of analytical tools and new molecules designed to specifically increase the level of protein -GlcNAcylation. The level of -GlcNAc modification appears to have either deleterious or beneficial effects, depending on the context (exposure time, pathophysiological context). While high -GlcNAcylation levels are mostly reported in chronic diseases, the increase in -GlcNAc level in acute stresses such as during ischemia reperfusion or hemorrhagic shock is reported to be beneficial , or . Read More

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http://dx.doi.org/10.3389/fendo.2018.00819DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340935PMC
January 2019

[Possible Segmental Arterial Mediolysis Associated with Intraperitoneal Hemorrhage in the Acute Stage of Subarachnoid Hemorrhage:A Case Report].

No Shinkei Geka 2019 Jan;47(1):97-103

Department of Neurosurgery, Kyoto University Graduate School of Medicine.

Segmental arterial mediolysis(SAM)is a rare non-inflammatory and non-atherosclerotic arteriopathy associated with the occurrence of multiple aneurysms such as intracranial and intraperitoneal aneurysms. We report a case of intraperitoneal hemorrhage that occurred during the acute stage of subarachnoid hemorrhage(SAH). An 82-year-old woman presented with a sudden onset of loss of consciousness with a diagnosis of SAH. Read More

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http://dx.doi.org/10.11477/mf.1436203902DOI Listing
January 2019
1 Read

Slow as Compared to Rapid Rewarming After Mild Hypothermia Improves Survival in Experimental Shock.

J Surg Res 2019 Apr 28;236:300-310. Epub 2018 Dec 28.

Institute of Physiological Chemistry, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.

Background: Accidental hypothermia following trauma is an independent risk factor for mortality. However, in most experimental studies, hypothermia clearly improves outcome. We hypothesized that slow rewarming is beneficial over rapid rewarming following mild hypothermia in a rodent model of hemorrhagic shock. Read More

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http://dx.doi.org/10.1016/j.jss.2018.11.057DOI Listing
April 2019
1 Read

Expanding the trauma code to other causes of hemorrhagic shock — ruptured abdominal aortic aneurysms

Can J Surg 2019 Feb;62(1):E17-E18

From the Division of Vascular and Endovascular Surgery, The Ottawa Hospital, Ottawa, Ont. (Chehroudi, Jetty); and the Division of General Surgery, The Ottawa Hospital, Ottawa, Ont. (Lampron).

Summary: Expediting life-saving care for hemorrhagic shock through multi-disciplinary code protocols is a potential method to improve outcomes. Trauma codes have become standard of care at most tertiary care centres; however, it is unclear if similar protocols can improve delivery of care for other forms of hemorrhagic shock. We examined the feasibility of a code protocol for ruptured abdominal aortic aneurysms (RAAAs) by reviewing the literature and comparing patient outcomes for RAAA and trauma patients at our institution, where the latter have a wellestablished trauma code protocol. Read More

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http://dx.doi.org/10.1503/cjs.018717DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351263PMC
February 2019
1 Read

[Two Cases of Aneurysm Rupture in Advanced Colorectal Cancer Successfully Treated with Selective Trans-Catheter Arterial Embolization].

Gan To Kagaku Ryoho 2018 Dec;45(13):1937-1939

Dept. of Surgery, Shuuwa General Hospital.

We report 2 successful cases treated with trans-catheter arterial embolization(TAE)for hemorrhagic shock due to pseudoaneurysm rupture at the primary tumor site in advanced colorectal cancer. Case 1: A 73-year-old female underwent Hartmann surgery at another hospital for rectal perforation and peritonitis. Six months later, she had a massive bloody stool and was transferred to our hospital. Read More

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December 2018
1 Read

The Dual Neuroprotective-Neurotoxic Effects of Sevoflurane After Hemorrhagic Shock Injury.

J Surg Res 2019 Mar 5;235:591-599. Epub 2018 Dec 5.

Department of Gerontology, Cangzhou Central Hospital, Cangzhou, China.

Background: The neuroprotection and neurotoxicity induced by sevoflurane have been gradually established. Choosing anesthetic agents after hemorrhage shock and resuscitation (HSR) induced by bleeding can be challenging. We determined the dual neuroprotective-neurotoxic effects of sevoflurane postconditioning after HSR injury using a model of blood loss and reinfusion in rats via the heme oxygenase-1 (HO-1)/reactive oxygen species (ROS) signal pathway. Read More

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http://dx.doi.org/10.1016/j.jss.2018.10.046DOI Listing

Exogenous ghrelin ameliorates acute lung injury by modulating the nuclear factor κB inhibitor kinase/nuclear factor κB inhibitor/nuclear factor κB pathway after hemorrhagic shock.

Int Immunopharmacol 2019 Jan 24;69:95-102. Epub 2019 Jan 24.

Department of Anesthesiology, The Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Road, Nangang District, Harbin 150001, China. Electronic address:

Previous studies have shown that ghrelin, a peptide produced in the stomach, attenuates acute lung injury (ALI) in various animal models, and that some of these effects are associated with inhibition of the nuclear factor κB signaling pathway. This study investigated whether ghrelin exerts beneficial effects on hemorrhagic shock (HS)-induced ALI by modulating nuclear factor κB inhibitor kinase/nuclear factor κB inhibitor/nuclear factor κB (IKK/IκBα/NF-κB) pathway activity. HS was induced in male SD rats by withdrawing blood to a mean arterial pressure (MAP) of 40 mm Hg for 1 h; rats then received ghrelin (10 nmol/kg) or vehicle intravenously and were resuscitated with the shed blood and an equal volume of Ringer lactate solution followed by observation for 2 h. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.01.019DOI Listing
January 2019

Hemorrhagic shock resulting from varicella zoster gastritis in a non-immunocompromised patient.

Int J Infect Dis 2019 Jan 25. Epub 2019 Jan 25.

Service de Réanimation Médicale, Hôpitaux Universitaires Henri Mondor-Albert Chenevier, Assistance Publique-Hôpitaux de Paris, Créteil, France; Groupe de Recherche Clinique CARMAS, Université Paris-Est Créteil, IMRB, Créteil, France.

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http://dx.doi.org/10.1016/j.ijid.2019.01.042DOI Listing
January 2019
1 Read
2.330 Impact Factor

AUTOMATED NONINVASIVE EVALUATION OF BLOOD FLOW AND OXYGENATION IN RATS INTEGRATED WITH SYSTEMIC PHYSIOLOGICAL MONITORING.

J Trauma Acute Care Surg 2019 Jan 25. Epub 2019 Jan 25.

Damage Control Resuscitation, U.S. Army Institute of Surgical Research, JBSA Fort Sam Houston, TX 78234.

Background: Many studies evaluating blood flow and oxygen partial pressure (PO2) do not directly measure both parameters, are confined to few locations/microvessels, and depend on investigator's selection of measuring sites. Moreover, clinically/physiologically-relevant systemic parameters are not simultaneously recorded. We implemented an automated system for prolonged blood flow/PO2 acquisition in large areas while collecting relevant systemic information. Read More

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http://dx.doi.org/10.1097/TA.0000000000002199DOI Listing
January 2019
3 Reads

Dengue Vaccine Development: Global and Indian Scenarios.

Int J Infect Dis 2019 Jan 23. Epub 2019 Jan 23.

Recombinant Gene Products Group, Molecular Medicine Division, International Centre for Genetic Engineering & Biotechnology, Aruna Asaf Ali Marg, New Delhi, India; Translational Health Science & Technology Institute, NCR Biotech Science Cluster, Faridabad, India. Electronic address:

India is home to nearly a third of the global population at risk of dengue, a viral disease caused by four antigenically and genetically distinct dengue viruses. Clinical illness following dengue virus infection could either be mild and self-limiting dengue fever or severe dengue hemorrhagic fever/dengue shock syndrome, with potentially fatal consequences. A live attenuated vaccine known as Dengvaxia, developed by Sanofi, was licensed in 2015. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S12019712193004
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http://dx.doi.org/10.1016/j.ijid.2019.01.029DOI Listing
January 2019
6 Reads

Intravenous injection of post-hemorrhagic shock mesenteric lymph induces multiple organ injury in rats.

Exp Ther Med 2019 Feb 5;17(2):1449-1455. Epub 2018 Dec 5.

Institute of Microcirculation, Hebei North University, Zhangjiakou, Hebei 075000, P.R. China.

Post-hemorrhagic shock mesenteric lymph (PHSML) has an important role in the multiple organ injuries caused by severe shock. The current study investigated whether intravenous injection of PHSML induces organ injury in normal rats. Following the establishment of hemorrhagic shock in donor rats (40±2 mmHg, 3 h), PHSML was drained during hypotension at 1-3 h and then injected to normal rats through the femoral vein within 30 min. Read More

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http://dx.doi.org/10.3892/etm.2018.7048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327623PMC
February 2019
1 Read

Increased Carotid Intima-Media Thickness in Children with a History of Dengue Hemorrhagic Fever.

Am J Trop Med Hyg 2019 Jan 21. Epub 2019 Jan 21.

Julius Global Health/Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.

We assessed carotid intima-media thickness (cIMT) and arterial stiffness in 28 children and adolescents with previous dengue hemorrhagic fever (DHF) (mean interval between DHF and cardiovascular assessment, 8.4 years), and 34 controls in a low-resource setting. Participants with previous DHF had an adjusted increased cIMT of 42. Read More

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http://dx.doi.org/10.4269/ajtmh.18-0672DOI Listing
January 2019
1 Read

Avocado (Persea americana) fruit extract (2R,4R)-1,2,4-trihydroxyheptadec-16-yne inhibits dengue virus replication via upregulation of NF-κB-dependent induction of antiviral interferon responses.

Sci Rep 2019 Jan 23;9(1):423. Epub 2019 Jan 23.

Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.

Dengue virus (DENV) caused millions of infections around the world annually. Co-infection with different serotypes of DENV is associated with dengue hemorrhagic shock syndrome, leading to an estimate of 50% death rate. No approved therapies are currently available for the treatment of DENV infection. Read More

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http://www.nature.com/articles/s41598-018-36714-4
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http://dx.doi.org/10.1038/s41598-018-36714-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344542PMC
January 2019
3 Reads

Enhanced prehospital volume therapy does not lead to improved outcomes in severely injured patients with severe traumatic brain injury.

BMC Emerg Med 2019 Jan 23;19(1):13. Epub 2019 Jan 23.

Department of Trauma, University Hospital and University of Zurich, Zürich, Switzerland.

Background: Whether enhanced prehospital volume therapy leads to outcome improvements in severely injured patients with severe traumatic brain injury (TBI) remains controversial. The aim of this study was to investigate the influence of prehospital volume therapy on the clinical course of severely injured patients with severe TBI.

Methods: Data for 122,672 patients from TraumaRegister DGU (TR-DGU) was analyzed. Read More

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https://bmcemergmed.biomedcentral.com/articles/10.1186/s1287
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http://dx.doi.org/10.1186/s12873-019-0221-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343344PMC
January 2019
4 Reads

Resuscitative endovascular balloon occlusion of the aorta: current evidence.

Open Access Emerg Med 2019 14;11:29-38. Epub 2019 Jan 14.

Department of Surgery, The University of Texas Health Science Center, McGovern Medical School, Houston, TX, USA.

Resuscitative endovascular balloon occlusion of the aorta (REBOA) has recently gained popularity as a minimally invasive alternative to open aortic cross-clamping in the management of patients with non-compressible hemorrhage arising below the diaphragm. The purpose of this review is to provide a description of the technical aspects of REBOA use along with an overview of the current animal and clinical data regarding its use. Read More

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http://dx.doi.org/10.2147/OAEM.S166087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336022PMC
January 2019
1 Read

[Dexmedetomidine preconditioning protects against lung injury in hemorrhagic shock rats].

Rev Bras Anestesiol 2019 Jan 14. Epub 2019 Jan 14.

Wuhan University, Renmin Hospital, Department of Anesthesiology, Wuhan, Hubei, China; Wuhan University, Renmin Hospital, Laboratory of Anesthesiology and Critical Care Medicine, Wuhan, Hubei, China. Electronic address:

Background And Objectives: Dexmedetomidine has demonstrated protective effects against lung injury in vitro. Here, we investigated whether dexmedetomidine preconditioning protected against lung injury in hemorrhagic shock rats.

Methods: Male Sprague-Dawley rats were randomly divided into four groups (n=8): control group, hemorrhagic shock group, 5ug. Read More

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http://dx.doi.org/10.1016/j.bjan.2018.09.011DOI Listing
January 2019
2 Reads
0.415 Impact Factor

Renin as a Marker of Tissue-Perfusion and Prognosis in Critically Ill Patients.

Crit Care Med 2019 Feb;47(2):152-158

Department of Intensive Care, Cliniques Universitaires de Bruxelles-Hôpital Erasme, Brussels, Belgium.

Objectives: To characterize renin in critically ill patients. Renin is fundamental to circulatory homeostasis and could be a useful marker of tissue-perfusion. However, diurnal variation, continuous renal replacement therapy and drug-interference could confound its use in critical care practice. Read More

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http://dx.doi.org/10.1097/CCM.0000000000003544DOI Listing
February 2019
2 Reads

Madelung's disease: long-term follow-up.

J Surg Case Rep 2019 Jan 9;2019(1):rjy356. Epub 2019 Jan 9.

Department of Human Pathology, Matsunami General Hospital, 185-1, Dendai, Kasamatsu, Hashima-gun, Gifu, Japan.

Madelung's disease (MD) is a rare lipid metabolic disorder of adipose tissue overgrowth, which has been reported to be related to alcohol abuse. Although it does not affect survival itself, alcoholism and metabolic disorders associated with MD can be life-threatening. Although surgical procedures and classifications have been reported, long-term follow-up has rarely been reported. Read More

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http://dx.doi.org/10.1093/jscr/rjy356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326107PMC
January 2019
2 Reads

Extracellular CIRP (eCIRP) and inflammation.

J Leukoc Biol 2019 Jan 15. Epub 2019 Jan 15.

Center for Immunology and Inflammation, The Feinstein Institute for Medical Research, Manhasset, New York, USA.

Cold-inducible RNA-binding protein (CIRP) was discovered 2 decades ago while studying the mechanism of cold stress adaptation in mammals. Since then, the role of intracellular CIRP (iCIRP) as a stress-response protein has been extensively studied. Recently, extracellular CIRP (eCIRP) was discovered to also have an important role, acting as a damage-associated molecular pattern, raising critical implications for the pathobiology of inflammatory diseases. Read More

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http://doi.wiley.com/10.1002/JLB.3MIR1118-443R
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http://dx.doi.org/10.1002/JLB.3MIR1118-443RDOI Listing
January 2019
4 Reads

Clinical Course and Management of Dengue in Children Admitted to Hospital; A 5 Years Prospective Cohort Study in Jakarta, Indonesia.

Pediatr Infect Dis J 2019 Jan 9. Epub 2019 Jan 9.

Background: Dengue incidence is rising globally which was estimated 100 million per year, whereas in Indonesia was estimated 7.5 million per year. Dengue clinical course varies from mild dengue fever (DF) to dengue hemorrhagic fever (DHF) or dengue shock syndrome (DSS). Read More

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http://dx.doi.org/10.1097/INF.0000000000002277DOI Listing
January 2019
2 Reads

Valproic Acid and Neural Apoptosis, Inflammation, and Degeneration 30 Days after Traumatic Brain Injury, Hemorrhagic Shock, and Polytrauma in a Swine Model.

J Am Coll Surg 2019 Jan 9. Epub 2019 Jan 9.

Department of Surgery, University of Michigan Health System, Ann Arbor, MI. Electronic address:

Background: A single-dose (150 mg/kg) of valproic acid (VPA) has been shown to decrease brain lesion size and improve neurologic recovery in preclinical models of traumatic brain injury (TBI). However, the longer-term (30 days) impact of single-dose VPA treatment after TBI has not been well evaluated.

Study Design: Yorkshire swine were subjected to TBI (cortical impact), hemorrhagic shock, and polytrauma. Read More

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http://dx.doi.org/10.1016/j.jamcollsurg.2018.12.026DOI Listing
January 2019
2 Reads

[Adams-Oliver syndrome and cutis marmorata telangiectatica congenita].

Ann Dermatol Venereol 2019 Jan 9. Epub 2019 Jan 9.

Service de néonatologie et réanimation néonatale, CHU Hassan II, Fès, Maroc.

Adams-Oliver syndrome (AOS) is a congenital condition characterized by congenital aplasia cutis and transverse limb defects. Herein we report a case of an infant with severe intra-uterine growth restriction presenting AOS associated with cutis marmorata telangiectatica but with no other organ complications. The outcome was complicated by hemorrhagic and septic shock, which resulted in the death of the infant in a setting of multiorgan failure. Read More

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http://dx.doi.org/10.1016/j.annder.2018.11.009DOI Listing
January 2019
5 Reads

Miliary pattern MRSA sepsis following clandestine intravenous infusion.

Forensic Sci Med Pathol 2019 Jan 12. Epub 2019 Jan 12.

Office of the Medical Examiner, Greenville County, South Carolina, Pathology Associates of Greenville and the Greenville Health System University Medical Center, Greenville, SC, USA.

Intravascular devices aid in drug administration and fluid replacement for hospitalized patients and are thus an integral part of modern medical care; however, poor aseptic technique and improper manipulation of infusion devices increase the risk of infections secondary to catheterization that can progress to sepsis and septic shock. We report the case of a woman who presented with altered mental status after receiving normal saline through an intravenous catheter placed by a medically untrained individual. Less than 24 h following her initial presentation to emergency medical services the patient became unresponsive to multiple vasopressors and broad-spectrum antibiotics and succumbed to septic shock. Read More

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http://dx.doi.org/10.1007/s12024-018-0077-5DOI Listing
January 2019
1 Read

[Abdominal gunshot wounds: experiences in the Emergency Department at the Hassan II University Hospital in Fes, Morocco].

Pan Afr Med J 2018 8;30:265. Epub 2018 Aug 8.

Service de Chirurgie Digestive et Endocrinienne, CHU Hassan II, Fès, Maroc.

We report the case of a young couple, a 30-year old man and his 21-year old wife victim, after a family conflict, of shotgun shooting. Shotgun is allowed in Morocco during the game hunting season. Surgical exploration of both patients showed multiple lesions of the digestive tract as well vascular wound on the man's femoral artery causing hemorrhagic shock. Read More

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http://dx.doi.org/10.11604/pamj.2018.30.265.9133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317401PMC
January 2019

Extracorporeal potassium binding for the management of hyperkalemia in an anephric model of crush injury.

J Trauma Acute Care Surg 2019 Jan 10. Epub 2019 Jan 10.

Clinical Investigation Facility, David Grant USAF Medical Center, Travis Air Force Base, CA.

Background: Potassium-binding polymers have shown promising results in an anephric porcine hyperkalemia model. The benefits of the polymer in a clinically-relevant injury model remain unknown. We hypothesized that potassium-binding cartridges would control serum potassium concentration in a porcine hemorrhagic shock model with supraceliac aortic occlusion and a limb crush injury. Read More

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http://dx.doi.org/10.1097/TA.0000000000002178DOI Listing
January 2019
3 Reads

The Hippo-YAP Pathway Regulates the Proliferation of Alveolar Epithelial Progenitors after Acute Lung Injury.

Cell Biol Int 2019 Jan 11. Epub 2019 Jan 11.

State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Surgery Research, Daping Hospital, Military Medical University, Chongqing 400042, China.

Regeneration of pulmonary epithelial cells plays an important role in the recovery of acute lung injury (ALI) which is defined by pulmonary epithelial cell death. However, the mechanism of the regenerative capacity of alveolar epithelial cells is unknown. Using a lung injury mouse model induced by hemorrhagic shock and LPS, a protein mass spectrometry-based high-throughput screening and linage tracing technology to mark alveolar epithelial type 2 cells (AEC2s), we analyzed the mechanism of alveolar epithelial cells proliferation. Read More

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http://doi.wiley.com/10.1002/cbin.11098
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http://dx.doi.org/10.1002/cbin.11098DOI Listing
January 2019
7 Reads

Guidelines for Colonic Diverticular Bleeding and Colonic Diverticulitis: Japan Gastroenterological Association.

Digestion 2019 9;99 Suppl 1:1-26. Epub 2019 Jan 9.

Japanese Gastroenterological Association, Tokyo, Japan.

Colonic diverticular disease has been increasing in prevalence in Japan due to the rapidly aging population. Colonic diverticular bleeding can result in hemorrhagic shock requiring blood transfusion, and it carries a high risk of recurrence within 1 year. Colonic diverticulitis can cause abscess, fistula formation, and perforation of the colon that may require surgery, and it often recurs. Read More

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https://www.karger.com/Article/FullText/495282
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http://dx.doi.org/10.1159/000495282DOI Listing
January 2019
20 Reads

Deficiency of metabolite sensing receptor HCA2 impairs the salutary effect of niacin in hemorrhagic shock.

Biochim Biophys Acta Mol Basis Dis 2019 Mar 6;1865(3):688-695. Epub 2019 Jan 6.

Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, GA 30912, United States of America; Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, GA 30912, United States of America. Electronic address:

Inflammation and cellular energetics play critical roles in organ dysfunction following hemorrhagic shock. Recent studies suggest a putative role for sirtuin 1 (SIRT1) in potentiating mitochondrial function and improving organ function following hemorrhagic shock in animal models. SIRT1 is an NAD dependent protein deacetylase and increased availability of NAD has been shown to augment SIRT1 activity. Read More

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http://dx.doi.org/10.1016/j.bbadis.2019.01.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353685PMC
March 2019
3 Reads

VER-155008 induced Hsp70 proteins expression in fish cell cultures while impeding replication of two RNA viruses.

Antiviral Res 2019 Feb 6;162:151-162. Epub 2019 Jan 6.

Department of Biology, University of Waterloo, Waterloo, ON, Canada. Electronic address:

The heat-shock protein 70 (Hsp70) inhibitor, VER-155008 (VER), was explored as a potential antiviral agent for two RNA viruses important to fish aquaculture, viral hemorrhagic septicemia virus (VHSV) and infectious pancreatic necrosis virus (IPNV). Studies were done at a temperature of 14 °C, and with cell lines commonly used to propagate these viruses. These were respectively EPC from fathead minnow for VHSV and CHSE-214 from Chinook salmon embryo for IPNV. Read More

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http://dx.doi.org/10.1016/j.antiviral.2019.01.001DOI Listing
February 2019
2 Reads

Novel Role for PD-1:PD-L1 as Mediator of Pulmonary Vascular Endothelial Cell Functions in Pathogenesis of Indirect ARDS in Mice.

Front Immunol 2018 20;9:3030. Epub 2018 Dec 20.

Division of Surgical Research, Department of Surgery, Rhode Island Hospital/Alpert School of Medicine at Brown University, Providence, RI, United States.

Deficiency of the co-inhibitory receptor, Programmed cell death receptor (PD)-1, provides a survival benefit in our murine shock/sepsis model for the development of indirect acute respiratory distress syndrome (iARDS). Further, of clinical significance, patients that develop ARDS express increased PD-1 on their blood leukocytes. While PD-1 expression and its regulatory role have been associated with mainly T-cell responses, the contribution of its primary ligand, PD-L1, broadly expressed on non-immune cells such as lung endothelial cells (ECs) as well as immune cells, is less well-understood. Read More

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https://www.frontiersin.org/article/10.3389/fimmu.2018.03030
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http://dx.doi.org/10.3389/fimmu.2018.03030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306416PMC
December 2018
5 Reads

A rare intrahepatic subcapsular hematoma (ISH) after laparoscopic cholecystectomy: a case report and literature review.

BMC Surg 2019 Jan 7;19(1). Epub 2019 Jan 7.

Department of General Surgery, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100730, China.

Background: Intrahepatic subcapsular hematoma (ISH) is an extremely rare, life-threatening complication after laparoscopic cholecystectomy (LC). Only few cases have been reported. Herein, we reported a rare giant ISH after LC and summarized all of the reported cases. Read More

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https://bmcsurg.biomedcentral.com/articles/10.1186/s12893-01
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http://dx.doi.org/10.1186/s12893-018-0453-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323672PMC
January 2019
10 Reads

Volume replacement strategies do not impair the binding of dabigatran to idarucizumab: Porcine model of hemodilution.

PLoS One 2019 7;14(1):e0209350. Epub 2019 Jan 7.

Laboratory for Clinical Thrombosis and Haemostasis, Department of Internal Medicine, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, The Netherlands.

Background: Idarucizumab is a humanized Fab fragment that specifically reverses dabigatran anticoagulation. In trauma, volume expanders are used for resuscitation to compensate for blood loss and hemorrhagic shock, but it is unknown whether volume expanders influence the binding of dabigatran to its antidote. Using a porcine dilutional coagulopathy model, this study investigated whether volume replacement strategies affect binding of dabigatran to idarucizumab. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0209350PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322768PMC
January 2019
1 Read

Infectious Disease: Mosquito-Borne Viral Illnesses.

FP Essent 2019 Jan;476:11-17

University of South Dakota Sanford School of Medicine Department of Family Medicine, 414 E. Clark Street, Vermillion, SD 57069.

Due to rapid globalization and ease of travel, mosquito-borne viral infections are now a concern for family physicians throughout the United States. Zika virus infection is one such concern. It is spread via mosquito bites or by sexual contact with an infected individual. Read More

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January 2019
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Traumatic Brain Injury May Worsen Clinical Outcomes After Prolonged Partial Resuscitative Endovascular Balloon Occlusion of the Aorta (pREBOA) in Severe Hemorrhagic Shock Model.

J Trauma Acute Care Surg 2018 Nov 27. Epub 2018 Nov 27.

Department of Surgery, University of Michigan, Ann Arbor, MI, USA.

Background: The use of partial resuscitative endovascular balloon occlusion of the aorta (pREBOA) in combined hemorrhagic shock (HS) and traumatic brain injury (TBI) has not been well studied. We hypothesized that the use of pREBOA in the setting of TBI would be associated with worse clinical outcomes.

Methods: Female Yorkshire swine were randomized to the following groups: HS + TBI; HS + TBI + pREBOA; and HS + pREBOA, (n=5/cohort). Read More

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http://dx.doi.org/10.1097/TA.0000000000002149DOI Listing
November 2018
2 Reads

Antibiotic use in patients with abdominal injuries: guideline by the Korean Society of Acute Care Surgery.

Ann Surg Treat Res 2019 Jan 26;96(1):1-7. Epub 2018 Dec 26.

Division of Acute Care Surgery, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Purpose: A task force appointed by the Korean Society of Acute Care Surgery reviewed previously published guidelines on antibiotic use in patients with abdominal injuries and adapted guidelines for Korea.

Methods: Four guidelines were assessed using the Appraisal of Guidelines for Research and Evaluation II instrument. Five topics were considered: indication for antibiotics, time until first antibiotic use, antibiotic therapy duration, appropriate antibiotics, and antibiotic use in abdominal trauma patients with hemorrhagic shock. Read More

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http://dx.doi.org/10.4174/astr.2019.96.1.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306503PMC
January 2019
4 Reads

Histone Deacetylase Inhibitors: A Novel Strategy In Trauma And Sepsis.

Shock 2018 Dec 21. Epub 2018 Dec 21.

Department of Surgery, University of Michigan, Ann Arbor, MI, USA.

Trauma remains a leading cause of morbidity and mortality among all age groups in the United States. Hemorrhagic shock and traumatic brain injury (TBI) are major causes of preventable death in trauma. Initial treatment involves fluid resuscitation to improve the intravascular volume. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001308DOI Listing
December 2018
1 Read