15,476 results match your criteria Shock Hemorrhagic


Evaluation of new quality indicators for the TraumaRegister DGU using the systematic QUALIFY methodology.

Eur J Trauma Emerg Surg 2018 Dec 14. Epub 2018 Dec 14.

Department for Anesthesiology, Intensive Care Medicine, Emergency Medicine and Pain Therapy, Armed Forces Hospital Ulm, HEMS "Christoph 22", Oberer Eselsberg 40, 89081, Ulm, Germany.

Background: The TraumaRegister DGU (TR-DGU) of the German Trauma Society (Deutsche Gesellschaft für Unfallchirurgie, DGU) enables the participating hospitals to perform quality management. For that purpose, nine so-called audit filters have existed, since its foundation, which, inter alia, is listed in the Annual Report. The objective of this study effort is a revision of these quality indicators with the aim of developing pertinent new and reliable quality indicators for the management of severely injured patients. Read More

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http://dx.doi.org/10.1007/s00068-018-1055-zDOI Listing
December 2018
1 Read

The use of whole blood in US military operations in Iraq, Syria, and Afghanistan since the introduction of low-titer Type O whole blood: feasibility, acceptability, challenges.

Transfusion 2018 Dec 11. Epub 2018 Dec 11.

Armed Service Blood Program, Brooke Army Medical Center, JBSA-Fort Sam Houston, Texas.

Background: Hemorrhage is the leading cause of preventable death in military and civilian traumatic injury. Blood product resuscitation improves survival. Low-titer Type O Whole Blood (LTOWB) was recently re-introduced to the combat theater as a universal resuscitation product for hemorrhagic shock. Read More

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http://dx.doi.org/10.1111/trf.15086DOI Listing
December 2018
1 Read

New therapeutic strategy of hinokitiol in haemorrhagic shock-induced liver injury.

J Cell Mol Med 2018 Dec 8. Epub 2018 Dec 8.

Division of General Surgery, Department of Surgery, Taipei Medical University Hospital, Taipei, Taiwan.

Haemorrhagic shock and resuscitation (HS/R) may cause global ischaemia-reperfusion injury, which can result in systemic inflammation, multiorgan failure (particularly liver failure) and high mortality. Hinokitiol, a bioactive tropolone-related compound, exhibits antiplatelet and anti-inflammatory activities. Targeting inflammatory responses is a potential strategy for ameliorating hepatic injury during HS/R. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jcmm.14070
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http://dx.doi.org/10.1111/jcmm.14070DOI Listing
December 2018
2 Reads

A rat model of acute kidney injury through systemic hypoperfusion evaluated by micro-US, color and PW-Doppler.

Radiol Med 2018 Dec 12. Epub 2018 Dec 12.

Department of Radiology, University of Campania "L. Vanvitelli", Piazza Miraglia 2, 80138, Naples, Italy.

Aim: To create an animal model of acute renal ischemia induced by systemic hypoperfusion, controllable and reproducible to study, in real time, hemorrhagic shock changes with micro-imaging.

Animals And Methods: Hemorrhagic shock was induced in rats activating a syringe pump setup to remove 1 mL/min of blood, through the femoral artery catheter. The withdrawal was continued until the mean arterial pressure (MAP) dropped to 25-30 mmHg. Read More

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http://dx.doi.org/10.1007/s11547-018-0962-8DOI Listing
December 2018

Lower Body Negative Pressure: Physiological Effects, Applications, and Implementation.

Physiol Rev 2019 Jan;99(1):807-851

Physiology Section, Otto Loewi Research Center for Vascular Biology, Immunology and Inflammation, Medical University of Graz , Graz , Austria ; Department of Biomedical Physiology and Kinesiology, Simon Fraser University , Burnaby, British Columbia , Canada ; Battlefield Health & Trauma Center for Human Integrative Physiology, Combat Casualty Care Research Program, US Army Institute of Surgical Research, JBSA Fort Sam Houston, Texas.

This review presents lower body negative pressure (LBNP) as a unique tool to investigate the physiology of integrated systemic compensatory responses to altered hemodynamic patterns during conditions of central hypovolemia in humans. An early review published in Physiological Reviews over 40 yr ago (Wolthuis et al. Physiol Rev 54: 566-595, 1974) focused on the use of LBNP as a tool to study effects of central hypovolemia, while more than a decade ago a review appeared that focused on LBNP as a model of hemorrhagic shock (Cooke et al. Read More

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https://www.physiology.org/doi/10.1152/physrev.00006.2018
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http://dx.doi.org/10.1152/physrev.00006.2018DOI Listing
January 2019
2 Reads

Management of Acquired Hemophilia A in Elderly Patients.

Case Rep Hematol 2018 13;2018:6757345. Epub 2018 Nov 13.

Division of Hematology, Takasago-Seibu Hospital, Takasago 676-0812, Japan.

This report describes six elderly patients with acquired hemophilia A (AHA), including four individuals aged ≥90 years. Bleeding symptoms were subcutaneous or intramuscular hemorrhage (=4), hematuria (=1), and hemorrhagic shock after tooth extraction (=1). Factor VIII (FVIII) activity ranged from <1. Read More

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http://dx.doi.org/10.1155/2018/6757345DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260550PMC
November 2018

Pro-Inflammatory Actions of Red Blood Cell-Derived DAMPs.

Authors:
Viktória Jeney

Exp Suppl 2018 ;108:211-233

Faculty of Medicine, Department of Internal Medicine, University of Debrecen, Debrecen, Hungary.

Damage-associated molecular patterns (DAMPs) or alarmins are endogenous danger signals that are derived from damaged cells and extracellular matrix degradation, capable of triggering innate immune response to promote tissue damage repair. Hemolytic or hemorrhagic episodes are often associated with inflammation, even when infectious agents are absent, suggesting that damaged red blood cells (RBCs) release DAMPs.Hemoglobin (Hb) composes 96% of the dry weight of RBCs; therefore upon hemolysis, tremendous amounts of Hb are released into the extracellular milieu. Read More

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http://dx.doi.org/10.1007/978-3-319-89390-7_9DOI Listing
January 2018
3 Reads

An unusual case of pulmonary fat embolism following blunt trauma.

Forensic Sci Med Pathol 2018 Dec 7. Epub 2018 Dec 7.

Institute of Forensic Medicine, University of Belgrade - School of Medicine, 31a Deligradska str, Belgrade, 11000, Serbia.

Fat embolism is markedly underdiagnosed, even though it is a well-known phenomenon following fractures of the long bones, injury to subcutaneous fat tissue, rupture of a fatty liver, surgical operations on fatty tissues, septicemia, burns and barotrauma. Forensic pathologists tend to "simplify" autopsy report conclusion in cases with multiple injuries where fat embolism and exsanguination could be considered to be the concomitant causes of death. Herein we present a case of 24-year-old male who was beaten with a metal rod by several persons. Read More

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http://link.springer.com/10.1007/s12024-018-0053-0
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http://dx.doi.org/10.1007/s12024-018-0053-0DOI Listing
December 2018
1 Read

Effects of crystalloids and colloids on microcirculation, central venous oxygen saturation, and central venous-to-arterial carbon dioxide gap in a rabbit model of hemorrhagic shock.

J Anesth 2018 Dec 10. Epub 2018 Dec 10.

Department of Cardiovascular Surgery, Tokyo Women's Medical University, 8-1, Kawadacho Shinjuku-ku, Tokyo, 162-8666, Japan.

Objective: The effects of hydroxyethyl starch (HES) on microcirculation, central venous oxygen saturation (ScvO), and the central venous-to-arterial carbon dioxide gap (dCO) are studied in a rabbit model of hemorrhagic shock for elucidating the advantages and drawbacks of resuscitation with HES compared with crystalloids.

Methods: An ear chamber and sublingual mucosa were used to examine blood vessels by intravital microscopy. Hemorrhagic shock was induced by removing nearly half of the blood volume. Read More

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http://dx.doi.org/10.1007/s00540-018-2594-5DOI Listing
December 2018

Herpes Virus Entry Mediator (HVEM) Expression Promotes Inflammation/ Organ Injury in Response to Experimental Indirect-Acute Lung Injury.

Shock 2018 May 4. Epub 2018 May 4.

Div. of Surgical Research/Department of Surgery, Lifespan-Rhode Island Hospital and Brown University, Providence, RI, USA.

Therapeutic interventions to treat acute lung injury (ALI) remain largely limited to lung-protective strategies, as a real molecular pathophysiologically driven therapeutic intervention has yet to become available. While we have previously documented the expression of HVEM on leukocytes of septic mice and critically ill patients, its functional role in shock/sepsis-induced ALI has not yet been studied. Inasmuch; a murine model of indirect ALI (iALI) was induced by hemorrhagic shock (HEM) followed by cecal ligation and puncture (CLP), septic challenge and HVEM-siRNA or PBS was administrated by intra-tracheal instillation 2 hours after hemorrhage to determine the role of HVEM in the development of experimental iALI. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292778PMC

N 115 - Choc hémorragique.

J Obstet Gynaecol Can 2018 Dec;40(12):e883-e892

Saskatoon (Sask.).

Objectif: Passer en revue les aspects cliniques du choc hémorragique et formuler des recommandations pour son traitement.

Options: La reconnaissance précoce du choc hémorragique et une intervention rapide et systématique aident à éviter des issues indésirables. RéSULTATS ATTENDUS: Formuler des directives cliniques pour aider à reconnaître rapidement le choc hémorragique et à pratiquer la réanimation d'une manière organisée et fondée sur les connaissances scientifiques. Read More

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http://dx.doi.org/10.1016/j.jogc.2018.10.005DOI Listing
December 2018

No. 115-Hemorrhagic Shock.

J Obstet Gynaecol Can 2018 Dec;40(12):e874-e882

Saskatoon, SK.

Objective: To review the clinical aspects of hemorrhagic shock and provide recommendations for therapy.

Options: Early recognition of hemorrhagic shock and prompt systematic intervention will help avoid poor outcomes.

Outcomes: Establish guidelines to assist in early recognition of hemorrhagic shock and to conduct resuscitation in an organized and evidence-based manner. Read More

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http://dx.doi.org/10.1016/j.jogc.2018.10.004DOI Listing
December 2018

Partial Deletion of Tie2 Affects Microvascular Endothelial Responses to Critical Illness in a Vascular Bed and Organ-Specific Way.

Shock 2018 Jul 30. Epub 2018 Jul 30.

Department of Pathology and Medical Biology, Medical Biology section.

Tie2 is a tyrosine kinase receptor that is mainly expressed by endothelial cells. In animal models mimicking critical illness, Tie2 levels in organs are temporarily reduced. Functional consequences of these reduced Tie2 levels on microvascular endothelial behaviour are unknown. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001226DOI Listing
July 2018
5 Reads

Caspase- (8/3) Activation and Organ Inflammation in a Rat Model of Resuscitated Hemorrhagic Shock: A Role for Uric Acid.

J Trauma Acute Care Surg 2018 Nov 30. Epub 2018 Nov 30.

Centre de Recherche de l'Hôpital du Sacré-Cœur de Montréal (HSCM), 5400 boul. Gouin Ouest, Montréal, Québec, H4J 1C5, Canada.

Background: Multiple organ failure can develop after hemorrhagic shock (HS). Uric acid (UA) is released from dying cells and can be pro-inflammatory. We hypothesized that UA could be an alternative mediator of organ apoptosis and inflammation after HS. Read More

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http://dx.doi.org/10.1097/TA.0000000000002152DOI Listing
November 2018
1 Read

Immune-mediated neurological manifestations of dengue virus- a study of clinico-investigational variability, predictors of neuraxial involvement, and outcome with the role of immunomodulation.

Neurol India 2018 Nov-Dec;66(6):1634-1643

Department of Neurology, Government Medical College Kota, Rajasthan, India.

Introduction: Our aim was to study dengue-related immune-mediated neurological complications (IMNC) during the recent epidemic.

Materials And Methods: This was a cross-sectional observational study of 79 IMNC cases from 1627 laboratory confirmed dengue cases from January 2015 to January 2016 and their follow-up for 3 months. According to the World Health Organization, cases were categorized into those having dengue fever (DF), and those having a severe syndrome that includes dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). Read More

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http://dx.doi.org/10.4103/0028-3886.246273DOI Listing
December 2018
5 Reads

Prehospital Tranexamic Acid Administration During Aeromedical Transport After Injury.

J Surg Res 2019 Jan 21;233:132-138. Epub 2018 Aug 21.

Division of Trauma, Department of Surgery, Section of General Surgery, University of Cincinnati, Cincinnati, Ohio. Electronic address:

Background: Tranexamic acid (TXA) has been shown to reduce mortality in the treatment of traumatic hemorrhage. This effect seems most profound when given early after injury. We hypothesized that extending a protocol for TXA administration into the prehospital aeromedical setting would improve outcomes while maintaining a similar safety profile to TXA dosed in the emergency department (ED). Read More

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http://dx.doi.org/10.1016/j.jss.2018.07.074DOI Listing
January 2019
1 Read

Intravenous Hydroxocobalamin Versus Hextend Versus Control for Class III Hemorrhage Resuscitation in a Prehospital Swine Model.

Mil Med 2018 Nov;183(11-12):e721-e729

CREST Research Program, Department of Emergency Medicine, San Antonio Military Medical Center, 3551 Roger Brooke Drive, Fort Sam Houston, TX.

Background: Hydroxyethyl starch (Hextend) has been used for hemorrhagic shock resuscitation, however, hydroxyethyl starch may be associated with adverse outcomes.

Objective: To compare systolic blood pressure (sBP) in animals that had 30% of their blood volume removed and treated with intravenous hydroxocobalamin, hydroxyethyl starch, or no fluid.

Methods: Twenty-eight swine (45-55 kg) were anesthetized and instrumented with continuous femoral and pulmonary artery pressure monitoring. Read More

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http://dx.doi.org/10.1093/milmed/usy173DOI Listing
November 2018
1 Read

Modulation of Endoplasmic Reticulum Stress Influences Ischemia-Reperfusion Injury After Hemorrhagic Shock.

Shock 2018 Nov 28. Epub 2018 Nov 28.

Department of Trauma Surgery, University of Heidelberg, Heidelberg, Germany.

Background: Impaired function of the endoplasmic reticulum (ER) results in ER stress, an accumulation of proteins in the ER lumen. ER stress is a major contributor to inflammatory diseases and is part of the pathomechanism of ischemia-reperfusion injury (IRI). Since severe traumatic injury is often accompanied by remote organ damage and immune cell dysfunction, we investigated the influence of ER stress modulation on the systemic inflammatory response and liver damage after hemorrhagic shock and reperfusion (HS/R). Read More

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http://dx.doi.org/10.1097/SHK.0000000000001298DOI Listing
November 2018

[Complications of intracameral cefuroxime in cataract surgery].

Vestn Oftalmol 2018 ;134(5):104-110

Volga District Medical Centre, Federal Medical and Biological Agency, 2 Nizhnevolgskaya Naberegnaya, Nizhny Novgorod, Russian Federation, 603001.

Intracameral injection of cefuroxime during phacoemulsification is considered effective in preventing endophthalmitis. Its widespread usage has led to the accumulation of data on local and systemic adverse reactions. The analysis of complications of cataract surgery with cefuroxime injections described in literature has allowed identifying a few different clusters of toxic and allergic reactions to intracameral cefuroxime for the first time. Read More

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http://dx.doi.org/10.17116/oftalma2018134051104DOI Listing
January 2018
1 Read

Tranexamic acid decreases rodent hemorrhagic shock-induced inflammation with mixed end-organ effects.

PLoS One 2018 29;13(11):e0208249. Epub 2018 Nov 29.

Department of Regenerative Medicine, Naval Medical Research Center, Silver Spring, Maryland, United States of America.

Beyond its anti-fibrinolytic mechanism, tranexamic acid has been suggested to have anti-inflammatory properties which may contribute to the survival benefit it provides to trauma patients. The objective of this study was to assess possible immunomodulatory effects of tranexamic acid as well as potential amelioration of end-organ injury in a rodent hemorrhagic shock model. Controlled hemorrhagic shock was induced in adult Sprague Dawley rats to a mean arterial pressure of 30 mmHg. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0208249PLOS
November 2018
5 Reads

Urushiol-functionalized mesoporous silica nanoparticles and their self-assembly into a Janus membrane as a highly efficient hemostatic material.

Nanoscale 2018 Dec;10(48):22818-22829

College of Chemistry and Materials Science, Fujian Normal University, Fuzhou 350007, People's Republic of China.

Quick hemostasis plays a very important role in preventing hemorrhagic shock and death by controlling blood loss from trauma in civil and military accidents. An ideal quick hemostat should have tissue-adhesive functional groups, clotting factor activating components, and a plasma non-permeable hydrophobic layer. Inspired by the adhesive behavior of mussels, a novel efficient hemostat of urushiol-functionalized mesoporous silica nanoparticles (MSN@U) with a core-shell structure was synthesized and their hemostatic performance was evaluated for the first time. Read More

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http://dx.doi.org/10.1039/c8nr05882bDOI Listing
December 2018
1 Read

Unexpected postpneumonectomy exertion-induced acute right heart failure.

Tumori 2018 Nov 28:300891618812682. Epub 2018 Nov 28.

4 Department of Anesthesia, Intensive Care and Palliative Care, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.

Introduction:: Thoracic surgery can have serious side effects. Accurate preoperative evaluation to assess which patients with anatomically resectable disease are suitable candidates for surgery is mandatory.

Case Description:: A 58-year-old man, scheduled for left pneumonectomy for lung cancer, passed all the preoperative examinations suggested by guidelines and underwent the surgery. Read More

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http://dx.doi.org/10.1177/0300891618812682DOI Listing
November 2018
3 Reads

Hypocoagulability and Platelet Dysfunction Are Exacerbated by Synthetic Colloids in a Canine Hemorrhagic Shock Model.

Front Vet Sci 2018 13;5:279. Epub 2018 Nov 13.

School of Veterinary and Life Sciences, College of Veterinary Medicine, Murdoch University Perth, WA, Australia.

Hemorrhagic shock and volume replacement can alter coagulation. Synthetic colloids, hydroxyethyl starch (HES), and gelatin, may enhance hypocoagulability. Our primary objective was to describe the effect of four fluid products on coagulation in canine hemorrhagic shock. Read More

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http://dx.doi.org/10.3389/fvets.2018.00279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243100PMC
November 2018

Levels of circulating microparticles in septic shock and sepsis-related complications: a case-control study.

Minerva Anestesiol 2018 Nov 22. Epub 2018 Nov 22.

Thrombotic and Hemorrhagic Diseases Unit, Department of Medicine DIMED, University of Padua, Padua, Italy -

Background: Microparticles (MP) have been largely studied as potential biomarkers in septic shock (SS) though their biological and clinical relevance is still unclear. This casecontrol study describes the trend of various MP subtypes during SS to evaluate their possible association with severity of illness and sepsisrelated complications (disseminated intravascular coagulation [DIC] and acute kidney injury [AKI]).

Methods: Forty patients admitted to the Intensive Care Unit with SS and forty matched healthy volunteers were recruited. Read More

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http://dx.doi.org/10.23736/S0375-9393.18.12782-9DOI Listing
November 2018
1 Read

Prostasin impairs epithelial growth factor receptor activation to suppress dengue virus propagation.

J Infect Dis 2018 Nov 23. Epub 2018 Nov 23.

Department of Biotechnology, College of Life Science, Kaohsiung Medical University, Kaohsiung, Taiwan.

Background: Dengue virus (DENV), a common and widely spread arbovirus, causes life-threatening diseases, such as dengue hemorrhagic fever or dengue shock syndrome. There is currently no effective therapeutic or preventive treatment for DENV infection.

Methods: Next-generation sequencing analysis revealed that prostasin expression was decreased upon DENV infection. Read More

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https://academic.oup.com/jid/advance-article/doi/10.1093/inf
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http://dx.doi.org/10.1093/infdis/jiy677DOI Listing
November 2018
14 Reads

Hemorrhage Attenuates Neutrophil Recruitment in Response to Secondary Respiratory Infection by Pseudomonas Aeruginosa.

Shock 2018 Nov 20. Epub 2018 Nov 20.

Division of Surgical Research, Department of Surgery, Rhode Island Hospital, Providence, RI 02903.

Neutrophil recruitment into the lung airspaces plays an important role in the containment and clearance of bacteria. Hemorrhagic shock, a complication of traumatic injury, induces immune dysfunction that compromises host defense and frequently leads to secondary infection. The objective of the current study was to determine whether prior hemorrhage impacts neutrophil recruitment in response to secondary Pseudomonas aeruginosa. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001288DOI Listing
November 2018
4 Reads

Management of Diabetic Ketoacidosis with Dengue Hemorrhagic Fever.

Cureus 2018 Sep 19;10(9):e3336. Epub 2018 Sep 19.

Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, THA.

Viral hemorrhagic fever is one of the most important emerging infectious diseases. Some viral hemorrhagic fevers include dengue, hantavirus, Ebola infection, and yellow fever. Dengue virus infection results in a wide spectrum of clinical diseases, including dengue hemorrhagic fever, characterized by the transient period of plasma leakage and hemorrhagic tendency. Read More

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https://www.cureus.com/articles/13041-management-of-diabetic
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http://dx.doi.org/10.7759/cureus.3336DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6248865PMC
September 2018
8 Reads

Habu coagulotoxicity: Clinical implications of the functional diversification of Protobothrops snake venoms upon blood clotting factors.

Toxicol In Vitro 2018 Nov 22;55:62-74. Epub 2018 Nov 22.

Venom Evolution Lab, School of Biological Sciences, University of Queensland, St Lucia, QLD 4072, Australia. Electronic address:

Venom can affect any part of the body reachable via the bloodstream. Toxins which specifically act upon the coagulation cascade do so either by anticoagulant or procoagulant mechanisms. Here we investigated the coagulotoxic effects of six species within the medically important pit viper genus Protobothrops (Habu) from the Chinese mainland and Japanese islands, a genus known to produce hemorrhagic shock in envenomed patients. Read More

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http://dx.doi.org/10.1016/j.tiv.2018.11.008DOI Listing
November 2018

Hyperlipidemia, statin use and dengue severity.

Sci Rep 2018 Nov 21;8(1):17147. Epub 2018 Nov 21.

Communicable Diseases Centre, Institute of Infectious Disease and Epidemiology, Tan Tock Seng Hospital, Singapore, 308433, Singapore.

Multiple in vitro and mice model studies suggest statins may attenuate dengue severity. However, little is known about statin use and dengue severity in adult dengue patients with hyperlipidemia. We conducted a retrospective cohort study from 2004-2008 and 2012-2013 in Tan Tock Seng Hospital, Singapore on adult dengue patients with hyperlipidemia, comparing those with and without statin usage at hospitalization in terms of primary outcome of dengue hemorrhagic fever (DHF) or shock syndrome (DSS), and severe dengue (SD). Read More

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http://dx.doi.org/10.1038/s41598-018-35334-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249290PMC
November 2018
4 Reads

Cerebral Blood Flow in Polytrauma: Transcranial Doppler Analysis in a Nonhuman Primate Shock Model.

J Surg Res 2018 Dec 5;232:146-153. Epub 2018 Jul 5.

Naval Medical Research Unit San Antonio, San Antonio, Texas. Electronic address:

Background: In combat-related trauma, resuscitation goals are to attenuate tissue hypoxia and maintain circulation. During hemorrhagic shock, compensatory and autoregulatory mechanisms are activated to preserve cerebral blood flow. Transcranial Doppler (TCD) ultrasonography may be an ideal noninvasive modality to monitor cerebral hemodynamics. Read More

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http://dx.doi.org/10.1016/j.jss.2018.05.062DOI Listing
December 2018
2 Reads

Traumatic brain injury is associated with increased syndecan-1 shedding in severely injured patients.

Scand J Trauma Resusc Emerg Med 2018 Nov 21;26(1):102. Epub 2018 Nov 21.

Center for Translational Injury Research (CeTIR), Department of Surgery, McGovern Medical School, University of Texas Health Science Center, 6431 Fannin, MSB 5.204, Houston, TX, 77030, USA.

Introduction: Head injury and exsanguination are the leading causes of death in trauma patients. Hemorrhagic shock triggers systemic endothelial glycocalyx breakdown, potentially leading to traumatic endotheliopathy (EoT). Levels of syndecan-1, a main glycocalyx component, have been used to assess the integrity of the glycocalyx. Read More

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http://dx.doi.org/10.1186/s13049-018-0565-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249764PMC
November 2018
3 Reads

Outcomes and risk factors of transfusion-associated circulatory overload: a case control study.

Transfusion 2018 Nov 20. Epub 2018 Nov 20.

Division Anesthésie Réanimation, Urgences Douleur, Centre Hospitalier Universitaire de Nîmes, Nîmes, France.

Background: Transfusion-associated circulatory overload (TACO) is a growing concern in clinical practice.

Study Design And Methods: A case control study was performed at the Nîmes University Hospital, France. TACO cases occurring after RBC transfusion reported from January 1, 2014, to May 31, 2017, were included as cases. Read More

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http://dx.doi.org/10.1111/trf.15040DOI Listing
November 2018
3 Reads

[Management and pregnancy outcomes of heterotopic pregnancy].

Zhonghua Fu Chan Ke Za Zhi 2018 Nov;53(11):768-775

Department of Obstetrics, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China.

To investigate the clinical features, diagnosis and treatments of heterotopic pregnancy (HP) and demonstrate the outcomes of HP after the surgical treatment of ectopic pregnancies. A retrospective analysis was performed on 144 cases of HP in Womens Hospital, School of Medicine, Zhejiang University from January 2003 to December 2016. (1) Clinical features of HP:the average age of patients was (30. Read More

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November 2018
4 Reads

Glycocalyx Degradation Is Independent of Vascular Barrier Permeability Increase in Nontraumatic Hemorrhagic Shock in Rats.

Anesth Analg 2018 Nov 16. Epub 2018 Nov 16.

From the Department of Translational Physiology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.

Background: Glycocalyx shedding after traumatic hemorrhagic or septic shock, as well as different resuscitation fluids, has been causally linked to increased vascular barrier permeability (VBP) resulting in tissue edema. In nontraumatic hemorrhagic shock (NTHS), it remains questionable whether glycocalyx degradation in itself results in an alteration of VBP. The composition of fluids can also have a modulatory effect on glycocalyx shedding and VBP. Read More

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http://dx.doi.org/10.1213/ANE.0000000000003918DOI Listing
November 2018
4 Reads

Thromboelastographic analysis of novel polyethylene glycol based low volume resuscitation solutions.

PLoS One 2018 15;13(11):e0207147. Epub 2018 Nov 15.

Department of Surgery, Division of Acute Care Surgery, Virginia Commonwealth University School of Medicine, Richmond, Virginia, United States of America.

Background: Low volume resuscitation (LVR) in shock prevents deleterious effects of crystalloid loading in pre-hospital settings. Polyethylene glycol 20,000 (PEG-20k) based LVR solutions are 20-fold more effective at maintaining perfusion and survival in shock compared to conventional crystalloids. The aim of this study was to determine coagulation and platelet function of whole blood treated with 10% PEG-20k. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0207147PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237338PMC
November 2018
3 Reads
3.234 Impact Factor

[Comparison of two schemes of daily arousal and comfort analgesia and sedation in patients on mechanical ventilation in intensive care unit].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2018 Oct;30(10):950-952

Department of Intensive Care Unit, Pingxiang People's Hospital, Pingxiang 337000, Jiangxi, China. Corresponding author: Guo Kun, Email:

Objective: To explore the efficacy of comfort analgesia and sedation in patients with mechanical ventilation in intensive care unit (ICU).

Methods: Eighty patients with mechanical ventilation admitted to ICU of Pingxiang People's Hospital from June 2017 to May 2018 were enrolled, and they were randomly divided into control group and observation group by random number table method, with 40 patients in each group. The control group was given a daily analgesic and sedation regimen with critical-care pain observation tool (CPOT) 0-3 and Richmond agitation-sedation scale (RASS) maintained at -3 to -4. Read More

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http://dx.doi.org/10.3760/cma.j.issn.2095-4352.2018.010.009DOI Listing
October 2018
1 Read

A Novel Method of Damage Control for Multiple Discontinuous Intestinal Injuries with Hemorrhagic Shock: A Controlled Experiment.

J Invest Surg 2018 Nov 15:1-10. Epub 2018 Nov 15.

a Department of General Surgery , Fuzhou General Hospital of the Chinese People's Liberation Army , Fuzhou , Fujian , China.

Aim: In this study, we examined the effects of branched silicon tube (BST) and temporary closed circle (TCC) in a Beagle dog model of multiple transection of small intestine and discontinuities suspected intestinal necrosis with hemorrhagic shock.

Materials And Methods: Ten male Beagle dogs were randomly divided into two groups. Hemorrhagic shock was induced by bleeding. Read More

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http://dx.doi.org/10.1080/08941939.2018.1527418DOI Listing
November 2018
6 Reads

Tranexamic Acid in Civilian Trauma Care in the California Prehospital Antifibrinolytic Therapy Study.

West J Emerg Med 2018 Nov 10;19(6):977-986. Epub 2018 Sep 10.

Arrowhead Regional Medical Center, Department of Emergency Medicine, Colton, California.

Introduction: Hemorrhage is one of the leading causes of death in trauma victims. Historically, paramedics have not had access to medications that specifically target the reversal of trauma-induced coagulopathies. The California Prehospital Antifibrinolytic Therapy (Cal-PAT) study seeks to evaluate the safety and efficacy of tranexamic acid (TXA) use in the civilian prehospital setting in cases of traumatic hemorrhagic shock. Read More

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https://escholarship.org/uc/item/9f99j268
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http://dx.doi.org/10.5811/westjem.2018.8.39336DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225940PMC
November 2018
4 Reads

Assessing hemorrhagic shock: Feasibility of using an ultracompact photoacoustic microscope.

J Biophotonics 2018 Nov 12:e201800348. Epub 2018 Nov 12.

Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, China.

Hemorrhagic shock, as an important clinical issue, is regarding as a critical disease with a high mortality rate. Unfortunately, existing clinical technologies are inaccessible to assess the hemorrhagic shock via hemodynamics in microcirculation. Here, we propose an ultracompact photoacoustic microscope to assess hemorrhagic shock using a rat model and demonstrate its clinical feasibility by visualizing buccal microcirculation of healthy volunteers. Read More

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http://doi.wiley.com/10.1002/jbio.201800348
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http://dx.doi.org/10.1002/jbio.201800348DOI Listing
November 2018
2 Reads
4.450 Impact Factor

ERK and miRNA-1 target Cx43 expression and phosphorylation to modulate the vascular protective effect of angiotensin II.

Life Sci 2019 Jan 9;216:59-66. Epub 2018 Nov 9.

State Key Laboratory of Trauma, Burns and Combined Injury, Second Department of Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing 400042, China. Electronic address:

Aims And Methods: We previously reported that angiotensin II (AngII) restores the vascular reactivity diminished by hemorrhagic shock. In this study, we investigated whether the beneficial effects of AngII are related to regulation of gap junctions (GJs) and connexin43 (Cx43), and the implication of MAPK signaling and microRNA (miR-1) in this process.

Key Findings: Our results show that after hemorrhagic shock or hypoxia, the blockade of GJs or knockdown of Cx43 inhibits the AngII-induced increase in vascular reactivity of superior mesenteric arteries and the contractile response of vascular smooth muscle cells (VSMCs). Read More

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http://dx.doi.org/10.1016/j.lfs.2018.11.019DOI Listing
January 2019
1 Read

Care of the Severely Injured Orthopedic Trauma Patient: Considerations for Initial Management, Operative Timing, and Ongoing Resuscitation.

Adv Anesth 2018 Dec 27;36(1):1-22. Epub 2018 Sep 27.

Department of Anesthesiology, University of Maryland School of Medicine, R Adams Cowley Shock Trauma Center, 22 South Greene Street, Suite T1R77, Baltimore, MD 21201, USA. Electronic address:

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http://dx.doi.org/10.1016/j.aan.2018.07.001DOI Listing
December 2018

Alcohol Binge Reduces Systemic Leukocyte Activation and Pulmonary PMN Infiltration After Blunt Chest Trauma and Hemorrhagic Shock.

Inflammation 2018 Nov 9. Epub 2018 Nov 9.

Department of Trauma, Hand and Reconstructive Surgery, University Hospital Frankfurt, Goethe-University, 60590, Frankfurt, Germany.

Blunt chest (thoracic) trauma (TxT) and hemorrhagic shock (HS)-induced local and systemic inflammation with increased neutrophil activity often result in an impaired organ function. Next to increasing the trauma risk, binge drinking causes anti-inflammatory effects due to immunomodulatory properties of alcohol (ethanol, EtOH). The impact of clinically relevant acute binge drinking scenario on local and systemic inflammatory changes, notably regarding the activity and longevity of leukocytes, has been analyzed in a combinatory trauma model of TxT + H/R. Read More

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http://link.springer.com/10.1007/s10753-018-0927-z
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http://dx.doi.org/10.1007/s10753-018-0927-zDOI Listing
November 2018
3 Reads

Whatever happened to the Shwartzman phenomenon?

Innate Immun 2018 Nov;24(8):466-479

3 The Infectious Disease Division, Rhode Island Hospital and the Alpert Medical School of Brown University, Providence, USA.

Ninety years ago, Gregory Shwartzman first reported an unusual discovery following the intradermal injection of sterile culture filtrates from principally Gram-negative strains from bacteria into normal rabbits. If this priming dose was followed in 24 h by a second intravenous challenge (the provocative dose) from same culture filtrate, dermal necrosis at the first injection site would regularly occur. This peculiar, but highly reproducible, event fascinated the microbiologists, hematologists, and immunologists of the time, who set out to determine the mechanisms that underlie the pathogenesis of this reaction. Read More

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http://dx.doi.org/10.1177/1753425918808008DOI Listing
November 2018
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Cardiac Effects of Hyperoxia During Resuscitation from Hemorrhagic Shock in Swine.

Shock 2018 Nov 6. Epub 2018 Nov 6.

Institut fu[Combining Diaeresis]r Ana[Combining Diaeresis]sthesiologische Pathophysiologie und Verfahrensentwicklung, Universita[Combining Diaeresis]tsklinikum Ulm, Ulm, Germany.

Hyperoxia (ventilation with FIO2 = 1.0) has vasoconstrictor properties, in particular in the coronary vascular bed, and, hence, may promote cardiac dysfunction. However, we previously showed that hyperoxia attenuated myocardial injury during resuscitation from hemorrhage in swine with coronary artery disease. Read More

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http://Insights.ovid.com/crossref?an=00024382-900000000-9771
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http://dx.doi.org/10.1097/SHK.0000000000001283DOI Listing
November 2018
7 Reads

Effect of Coagulation Factor Concentrates on Markers of Endothelial Cell Damage in Experimental Hemorrhagic Shock.

Shock 2018 Nov 29. Epub 2018 Nov 29.

Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, AUVA Trauma Research Center, Vienna.

Background: Plasma-based resuscitation showed protective effects on the endothelial glycocalyx compared to crystalloid resuscitation. There is paucity of data regarding the effect of coagulation factor concentrates (CFC) on the glycocalyx in hemorrhagic shock (HS). We hypothesized that colloid-based resuscitation supplemented with CFCs offers a therapeutic value to treat endothelial damage following HS. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001286DOI Listing
November 2018
5 Reads

[Prehospital plasma transfusion in civilian trauma patients in hemorrhagic shock].

Authors:
H Lier O Grottke

Anaesthesist 2018 Dec;67(12):950-952

Klinik für Anästhesiologie, Universitätsklinikum, RWTH Aachen, Aachen, Deutschland.

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http://link.springer.com/10.1007/s00101-018-0509-3
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http://dx.doi.org/10.1007/s00101-018-0509-3DOI Listing
December 2018
3 Reads

Blood on board: The development of a prehospital blood transfusion program in a Canadian helicopter emergency medical service.

CJEM 2018 Nov 8:1-9. Epub 2018 Nov 8.

*Shock Trauma Air Rescue Society,Calgary,AB.

CLINICIAN'S CAPSULE What is known about the topic? Emerging evidence regarding prehospital blood transfusions for patients in hemorrhagic shock is positive. What did this study ask? Describe the implementation and stewardship of a prehospital blood transfusion program, as well as basic demographics and blood traceability. What did this study find? We provided blood transfusion to 274 mainly male trauma patients, and just 1. Read More

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http://dx.doi.org/10.1017/cem.2018.457DOI Listing
November 2018

Nrf2 Regulates the Hepatoprotective Effects of Remote Ischemic Conditioning in Hemorrhagic Shock.

Antioxid Redox Signal 2018 Nov 7. Epub 2018 Nov 7.

St. Michael's Hospital, Department of Surgery, Toronto, Ontario, Canada.

Aims: Remote ischemic conditioning (RIC) protects against organ ischemia/reperfusion injury in experimental and clinical settings. We have demonstrated that RIC prevents liver and lung inflammation/injury following hemorrhagic shock/resuscitation (S/R). In the current study, we used a murine model of S/R to investigate the role of Nrf2 in mediating hepatoprotection. Read More

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https://www.liebertpub.com/doi/10.1089/ars.2018.7541
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http://dx.doi.org/10.1089/ars.2018.7541DOI Listing
November 2018
7 Reads