17,355 results match your criteria Shock Hemorrhagic


Club cell protein (CC)16 as potential lung injury marker in a porcine 72 h polytrauma model.

Eur J Trauma Emerg Surg 2022 May 21. Epub 2022 May 21.

Experimental Radiology, Department of Radiology and Nuclear Medicine, Otto-von-Guericke University, 39120, Magdeburg, Germany.

Background: Polytrauma and respiratory tract damage after thoracic trauma cause about 25% of mortality among severely injured patients. Thoracic trauma can lead to the development of severe lung complications such as acute respiratory distress syndrome, and is, therefore, of great interest for monitoring in intensive care units (ICU). In recent years, club cell protein (CC)16 with its antioxidant properties has proven to be a potential outcome-related marker. Read More

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Acute abdomen with Hemorrhagic shock while cruising on a private sailboat in the Atlantic Ocean.

J Travel Med 2022 May 19. Epub 2022 May 19.

Infectious Diseases consultant, Hirslanden Clinic Cecil and University Hospital of Lausanne, Switzerland.

This case report demonstrates that even in austere and remote environment (nearly the middle of the Atlantic Ocean), a severe medical case can be handled, but luck was probably part of the positive outcome. Read More

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"Zooming" in strategies and outcomes for trauma cases with Injury Severity Score (ISS) ≥16: promise or passé?

Rev Assoc Med Bras (1992) 2022 May 13. Epub 2022 May 13.

Giresun University, Faculty of Medicine, Division of Endocrine Surgery - Giresun, Turkey.

Objective: Rescuing severe trauma cases is extremely demanding. The present study purposed to analyze the efficiency of trauma management at Emergency Centre, University Clinical Centre of Serbia, Belgrade, included outcome within 28 days.

Methods: This retrospective study involved 131 intensive care unit trauma cases with total Injury Severity Score ≥16, in terms of administrating the two strategies: (i) definitive surgical repair and (ii) damage control laparotomy. Read More

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Valproic Acid During Hypotensive Resuscitation In Pigs With Trauma And Hemorrhagic Shock Does Not Improve Survival.

J Trauma Acute Care Surg 2022 May 21. Epub 2022 May 21.

U.S. Army Institute of Surgical Research, JBSA - Fort Sam Houston, TX 78234.

Background: Valproic acid (VPA) has been extensively used for treatment of anxiety and seizure. Recent studies have shown that VPA has cellular protective effects in preclinical models following severe hemorrhage. This study investigated the effects of VPA on coagulation and survival in pigs after traumatic hemorrhage and hypotensive resuscitation. Read More

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Endovascular Perfusion Augmentation for Critical Care Decreases Vasopressor Requirements while Maintaining Renal Perfusion.

Shock 2022 May;57(5):740-748

Department of Vascular/Endovascular Surgery, Wake Forest Baptist Medical Center, Winston-Salem, North Carolina.

Background: Ischemia reperfusion injury causes a profound hyperdynamic distributive shock. Endovascular perfusion augmentation for critical care (EPACC) has emerged as a hemodynamic adjunct to vasopressors and crystalloid. The objective of this study was to examine varying levels of mechanical support for the treatment of ischemiareperfusion injury in swine. Read More

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Paradoxical venous air embolism detected with point-of-care ultrasound: a case report.

Ultrasound J 2022 May 18;14(1):19. Epub 2022 May 18.

Cuidado Crítico, Hospital Universitario Nacional de Colombia, Bogotá D.C, Colombia.

Venous air embolism (VAE) is an uncommon event consistent in the entrainment of air from any communication between the environment and the venous vasculature that could occur during central venous catheter (CVC) manipulation, and might trigger circulatory shock within minutes depending on the amount of air embolized. We present a case of a critical care patient who presented sudden clinical hemodynamic deterioration after the removal of central venous catheter. Hemodynamic evaluation with point-of-care ultrasound (POCUS) showed bubbles in both right and left heart cavities wherewith air embolism facilitated by heart septal defect was suspected. Read More

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Hemorrhagic shock due to colonic arteriovenous malformation in late pregnancy: a case report.

Int J Emerg Med 2022 May 17;15(1):20. Epub 2022 May 17.

Interventional Radiology Center, Teikyo University Chiba Medical Center, 3426-3 Anesaki, Ichihara, Chiba, 299-0111, Japan.

Background: Intestinal arteriovenous malformations are difficult to detect because they often present asymptomatically. However, pregnancy increases the hemorrhagic risk of intestinal arteriovenous malformations. This can lead to massive bleeding and hemodynamic instability, threatening the lives of both the mother and fetus. Read More

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Clinicopathological alteration of symptoms with serotype among dengue infected pediatric patients.

J Med Virol 2022 May 16. Epub 2022 May 16.

ndian Council of Medical Research-National Institute of Cholera and Enteric Diseases, P-33, Scheme XM, CIT Road, Beliaghata, Kolkata, 700010, West Bengal, India.

Dengue fever is a self-limiting, acute febrile illness caused by an arbovirus. This infection may be asymptomatic or symptomatic with its potential life-threatening form as DHF/DSS. Severe dengue cases occur typically in children due to overproduction of pro-inflammatory and anti-inflammatory cytokines (called cytokines storm) as well as increased microvascular permeability in them. Read More

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[Predictive value of machine learning for in-hospital mortality for trauma-induced acute respiratory distress syndrome patients: an analysis using the data from MIMIC III].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2022 Mar;34(3):260-264

Department of Respiratory and Critical Care Medicine, the Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China. Corresponding author: Wang Daoxin, Email:

Objective: To investigate the value of machine learning methods for predicting in-hospital mortality in trauma patients with acute respiratory distress syndrome (ARDS).

Methods: A retrospective non-intervention case-control study was performed. Trauma patients with ARDS met the Berlin definition were extracted from the the Medical Information Mart for Intensive Care III (MIMIC III) database. Read More

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Local Mucosal CO but Not O Insufflation Improves Gastric and Oral Microcirculatory Oxygenation in a Canine Model of Mild Hemorrhagic Shock.

Front Med (Lausanne) 2022 28;9:867298. Epub 2022 Apr 28.

Department of Anesthesiology, Duesseldorf University Hospital, Duesseldorf, Germany.

Introduction: Acute hemorrhage results in perfusion deficit and regional hypoxia. Since failure of intestinal integrity seem to be the linking element between hemorrhage, delayed multi organ failure, and mortality, it is crucial to maintain intestinal microcirculation in acute hemorrhage. During critical bleeding physicians increase FiO to raise total blood oxygen content. Read More

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Effects of Sodium Thiosulfate During Resuscitation From Trauma-and-Hemorrhage in Cystathionine-γ-Lyase Knockout Mice With Diabetes Type 1.

Front Med (Lausanne) 2022 29;9:878823. Epub 2022 Apr 29.

Institut für Anästhesiologische Pathophysiologie und Verfahrensentwicklung, Universitätsklinikum Ulm, Ulm, Germany.

Background: Sodium thiosulfate (STS) is a recognized drug with antioxidant and HS releasing properties. We recently showed that STS attenuated organ dysfunction and injury during resuscitation from trauma-and-hemorrhage in CSE-ko mice, confirming its previously described organ-protective and anti-inflammatory properties. The role of HS in diabetes mellitus type 1 (DMT1) is controversial: genetic DMT1 impairs HS biosynthesis, which has been referred to contribute to endothelial dysfunction and cardiomyopathy. Read More

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TLR2/TLR4-Enhanced TIPE2 Expression Is Involved in Post-Hemorrhagic Shock Mesenteric Lymph-Induced Activation of CD4+T Cells.

Front Immunol 2022 29;13:838618. Epub 2022 Apr 29.

Institute of Microcirculation, Hebei North University, Zhangjiakou, China.

Purpose: Post hemorrhagic shock mesenteric lymph (PHSML) return contributes to CD4 T cell dysfunction, which leads to immune dysfunction and uncontrolled inflammatory response. Tumor necrosis factor α induced protein 8 like-2 (TIPE2) is one of the essential proteins to maintain the immune homeostasis. This study investigated the role of TIPE2 in regulation of CD4 T lymphocyte function in interaction of PHSML and TLR2/TLR4. Read More

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Mast Cells Drive Systemic Inflammation and Compromised Bone Repair After Trauma.

Front Immunol 2022 26;13:883707. Epub 2022 Apr 26.

Institute of Orthopedic Research and Biomechanics, Trauma Research Center Ulm (ZTF), Ulm University Medical Center, Ulm, Germany.

There is evidence that mast cells contribute to inflammation induced by hemorrhagic shock, severe tissue injury or sepsis. Mast cells are highly responsive to alarm signals generated after trauma, and release many inflammatory mediators including interleukin-6, a key mediator of posttraumatic inflammation. An overwhelming posttraumatic inflammation causes compromised bone healing; however, the underlying cellular and molecular mechanisms are poorly understood. Read More

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Endotracheal intubation in trauma patients with isolated shock: universally recommended but rarely performed.

Eur J Trauma Emerg Surg 2022 May 12. Epub 2022 May 12.

Department of Trauma and Orthopedic Surgery, Cologne-Merheim Medical Centre (CMMC), University of Witten/Herdecke, Ostmerheimerstr.200, 51109, Cologne, Germany.

Purpose: The indication for pre-hospital endotracheal intubation (ETI) must be well considered as it is associated with several risks and complications. The current guidelines recommend, among other things, ETI in case of shock (systolic blood pressure < 90 mmHg). This study aims to investigate whether isolated hypotension without loss of consciousness is a useful criterion for ETI. Read More

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Combat Casualty Relevant Dismounted Complex Blast Injury Model In Swine.

J Trauma Acute Care Surg 2022 May 12. Epub 2022 May 12.

Department of Vascular Surgery, University of Maryland School of Medicine, Baltimore, MD, United States.

Introduction: Improvised explosive devices (IEDs) have resulted in a unique polytrauma injury pattern termed Dismounted Complex Blast Injury (DCBI), which is frequent in the modern military theater. DCBI is characterized by extremity amputations, junctional vascular injury, and blast traumatic brain injury (bTBI). We developed a combat casualty relevant DCBI swine model, which combines hemorrhagic shock (HS) and tissue injury (TI) with a bTBI, to study interventions in this unique and devastating military injury pattern. Read More

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Percutaneous delivery of self-propelling thrombin-containing powder increases survival from non-compressible truncal hemorrhage in a swine model of coagulopathy and hypothermia.

J Trauma Acute Care Surg 2022 May 21. Epub 2022 May 21.

Department of Surgery, St. Michael's Hospital and University of Toronto, 30 Bond Street, Toronto, ON, Canada, M5B 1W8.

Background: Non-compressible truncal hemorrhage (NCTH) remains a leading cause of preventable death on the battlefield. Definitively managing severe NCTH requires surgery within the first hour after injury, which is difficult when evacuating casualties from remote and austere environments. During delays to surgery, hemostatic interventions that are performed prehospital can prevent coagulopathy and hemorrhagic shock and increase the likelihood that casualties survive to receive definitive care. Read More

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THE PHYSIOLOGY OF AORTIC FLOW AND PRESSURES DURING PARTIAL RESUSCITATIVE ENDOVASCULAR BALLOON OCCLUSION OF THE AORTA (pREBOA) IN A SWINE MODEL OF HEMORRHAGIC SHOCK.

J Trauma Acute Care Surg 2022 May 12. Epub 2022 May 12.

Background: Partial resuscitative endovascular balloon occlusion of the aorta (REBOA) has shown promise as a method to extend REBOA, but there lacks a standard definition of the technique. The purpose of this study was to investigate the relationships between distal and proximal mean arterial blood pressure (MAP) and distal aortic flow past a REBOA catheter. We hypothesize that a relationship between distal aortic flow and distal MAP in Zone 1 partial REBOA (pREBOA) is conserved and that there is no apparent relationship between aortic flow and proximal MAP. Read More

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Resuscitative endovascular balloon occlusion of the aorta in Canada: a context-specific position paper from the Canadian Collaborative for Urgent Care Surgery (CANUCS).

Can J Surg 2022 May-Jun;65(3):E310-E316. Epub 2022 May 11.

From the Department of Surgery, University of Alberta, Edmonton, Alta. (Bradley, Widder, Kim); the Department of Surgery, Western University, London, Ont. (Leeper, Parry, Vogt); the Department of Surgery, University of Ottawa, Ottawa, Ont. (Roberts, Lampron); the Department of Surgery, University of Calgary, Calgary, Alta. (Ball, Kirkpatrick); the Department of Surgery, University of Toronto, Toronto, Ont. (Beckett, Neto Rezende, Ahmed, Gomez); the Department of Surgery, McMaster University, Hamilton, Ont. (Engels, Nenshi, Rice); the Department of Surgery, University of British Columbia, Vancouver, BC (Joos, Hameed), the Departments of Surgery and of Critical Care Medicine, McGill University, Montréal, Que. (Khwaja); the Department of Surgery, Dalhousie University, Halifax, NS (Minor); the Department of Surgery, University of Manitoba, Winnipeg, Man. (Gillman); the Department of Surgery, Medical College of Wisconsin, Milwaukee, Wis. (Murphy).

Resuscitative endovascular balloon occlusion of the aorta (REBOA) is a well-described intervention for noncompressible torso hemorrhage. Several Canadian centres have included REBOA in their hemorrhagic shock protocols. However, REBOA has known complications and equipoise regarding its use persists. Read More

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Determination of risk factors associated with surgical site infection in patients undergoing preperitoneal pelvic packing for unstable pelvic fracture.

Acute Crit Care 2022 Apr 22. Epub 2022 Apr 22.

Department of Surgery, Yonsei University Wonju College of Medicine, Wonju, Korea.

Background: Several recent studies have shown that preperitoneal pelvic packing (PPP) effectively produces hemostasis in patients with unstable pelvic fractures. However, few studies have examined the rate of surgical site infections (SSIs) in patients undergoing PPP following an unstable pelvic fracture. The purpose of the present study was to evaluate factors associated with SSI in such patients. Read More

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Primitive Myxoid Mesenchymal Tumor of Infancy With Fatal Hemorrhage In Utero: A Case Report and Literature Review.

J Pediatr Hematol Oncol 2022 May 3. Epub 2022 May 3.

Departments of Pediatrics.

Primitive myxoid mesenchymal tumor of infancy (PMMTI) is a rare soft tissue sarcoma in childhood. We present the case of a newborn male who experienced a severe hemorrhage in utero from the tumor on the scalp. He died at the age of 24 hours owing to hemorrhagic shock. Read More

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Quantitative Evaluation of Small Intestinal Hemorrhage Using Energy Spectrum CT Iodine-Water Map.

Comput Math Methods Med 2022 28;2022:9234579. Epub 2022 Apr 28.

Radiographic Imaging Center, The Third Affiliated Hospital of Qiqihar Medical University, Qiqihar, 161000 Heilongjiang, China.

The objective of this research is to analyze the quantitative evaluation of human small intestinal bleeding by observing and analyzing animal experiments of small intestinal hemorrhage in rabbit models for the convenience of understanding the role of energy spectrum CT iodine-water diagram in animal experimental research of quantitative evaluation of small intestinal bleeding in rabbit models. Compared with the energy spectrum of iodine-water graph of a rabbit CT model, the present study studied the quantitative evaluation of small intestinal bleeding by using a rabbit model instead of human. According to the method mentioned above and the analysis of experimental data, the role of energy spectrum CT iodine-water map and the quantitative evaluation of human small intestinal bleeding have been understood. Read More

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Sevoflurane Improves Hemorrhagic Shock and Resuscitation-Induced Cognitive Impairments and Mitochondrial Dysfunctions through SIRT1-Mediated Autophagy.

Oxid Med Cell Longev 2022 11;2022:9771743. Epub 2022 Mar 11.

Department of Anesthesiology, The Second Affiliated Hospital of Anhui Medical University, Hefei City, Anhui Province, China.

Cerebral ischemia reperfusion injury (IRI) induced by hemorrhagic shock and reperfusion (HSR) is the main cause of death following trauma. Previous studies indicated the neuroprotective effect of sevoflurane postconditioning (SP) in cerebral IRI. However, the mechanisms still remain elusive. Read More

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Hemothorax as an Occult Cause of Hypotension After Transseptal Puncture.

Am J Case Rep 2022 May 9;23:e936188. Epub 2022 May 9.

Department of Anesthesiology, Ghent University Hospital, Ghent, Belgium.

BACKGROUND Catheter ablation is an increasingly used treatment modality for arrhythmias. Periprocedural complications have a low incidence but can be life-threatening. Therefore, knowledge of possible risks during the intervention and early recognition improve patient outcomes. Read More

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Whole blood for trauma resuscitation?

Injury 2022 May;53(5):1573-1575

Faculty of Medicine, University of Queensland; Joint Health Command, Australian Defence Force; Department of Intensive Care Medicine, Royal Brisbane and Women's Hospital.

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Platelet Transfusion and Outcomes After Massive Transfusion Protocol Activation for Major Trauma: A Retrospective Cohort Study.

Anesth Analg 2022 May 7. Epub 2022 May 7.

Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington.

Background: Incorporation of massive transfusion protocols (MTPs) into acute major trauma care has reduced hemorrhagic mortality, but the threshold and timing of platelet transfusion in MTP are controversial. This study aimed to describe early (first 4 hours) platelet transfusion practice in a setting where platelet counts are available within 15 minutes and the effect of early platelet deployment on in-hospital mortality. Our hypothesis in this work was that platelet transfusion in resuscitation of severe trauma can be guided by rapid turnaround platelet counts without excess mortality. Read More

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Antibiotic-impregnated external ventricular drainage for the management of post-hemorrhagic hydrocephalus in low birth weight premature infants following intraventricular hemorrhage.

Childs Nerv Syst 2022 May 5. Epub 2022 May 5.

Department of Neurosurgery, China Medical University Hospital, North District, No.2, Yude Road, Taichung City, 404472, Taiwan, Republic of China.

Purpose: This study aims to evaluate the infection rates and catheterization duration of applying antibiotic-impregnated external ventricular drain (EVD) for the treatment of post-hemorrhagic hydrocephalus (PHH) in low birth weight infants (LBWI).

Methods: This retrospective cohort study included 13 preterm LBWI with PHH. Data were collected from the patient's medical charts and included gender, gestational age, birth weight, intraventricular hemorrhage grade, ventriculostomy-associated infection (VAI), and the duration of catheterization. Read More

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First transfusion of cold-stored low-titer group O whole blood in the French armed forces.

Transfusion 2022 May 4. Epub 2022 May 4.

École du Val-de-Grâce, French Military Medical Academy, Paris, France.

Background: Hemorrhage is the most frequent cause of preventable death in the combat setting. Therefore, early transfusion can improve survival of combat casualties. In the case of hemorrhagic shock, massive transfusion must be performed immediately with high transfusion ratios (i. Read More

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[A woman with an abdominal swelling after coughing].

Ned Tijdschr Geneeskd 2022 04 19;166. Epub 2022 Apr 19.

Dijklander Ziekenhuis, Hoorn. Afd. Chirurgie.

We present the case of a 79-year old woman with acute abdominal swelling and pain after coughing. She was in hemorrhagic shock and received blood transfusion after which hemodynamic stabilization occured. This case illustrates that a rectus sheath hematoma can be the (uncommon) cause of acute abdominal pain and shock. Read More

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Management of a patient with cardiac arrest, intestinal ischemia necrosis, multiple fractures, hemorrhagic shock, renal failure, disseminated intravascular coagulation, and thrombosis after severe abdominal crush injury: A case report.

Exp Ther Med 2022 Jun 12;23(6):386. Epub 2022 Apr 12.

Center for Disease Control and Prevention, Western Theater Command, Lanzhou, Gansu 730020, P.R. China.

Abdominal crush injury has been widely reported. However, abdominal crush injury cases involving most of the organ systems have seldom been reported. In the present case report, a 58-year-old man was hit in the abdomen by a 4-ton machine tool. Read More

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Multidisciplinary Simulation Improves Resident Confidence for Pregnant Patients Requiring Surgical Intervention.

Cureus 2022 Mar 24;14(3):e23454. Epub 2022 Mar 24.

Simulation, Riverside Methodist Hospital/OhioHealth, Columbus, USA.

Introduction: Hepatocellular adenomas are a rare but serious cause of bleeding, which is further complicated by pregnancy. Interprofessional cooperation is a key component of residency education, thus simulations designed to integrate multiple programs are mutually beneficial. This simulation details surgical and obstetric management of a pregnant patient in hemorrhagic shock from a bleeding hepatocellular adenoma. Read More

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