16,226 results match your criteria Shock Hemorrhagic


Diffuse alveolar hemorrhage: how relevant is etiology?

Sarcoidosis Vasc Diffuse Lung Dis 2019 1;36(1):47-52. Epub 2019 May 1.

Pulmonology Department, Centro Hospitalar de Trás-os-Montes e Alto Douro.

Background: Diffuse Alveolar Hemorrhage (DAH) is a rare and potentially life-threatening clinical syndrome whose early recognition is essential.

Objectives: Characterization of patients with DAH and comparison of presentation and evolution of the disease according to etiology.

Methods: We retrospectively reviewed the clinical records of patients admitted to our hospital over a 7-year period with DAH. Read More

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http://dx.doi.org/10.36141/svdld.v36i1.7160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247111PMC

The compensatory reserve: potential for accurate individualized goal-directed whole blood resuscitation.

Transfusion 2020 Jun 1. Epub 2020 Jun 1.

Battlefield Health & Trauma Center for Human Integrative Physiology, United States Army Institute of Surgical Research, JBSA Fort Sam Houston, Texas.

Hemorrhagic shock can be mitigated by timely and accurate resuscitation designed to restore adequate delivery of oxygen (DO ). Current doctrine of using systolic blood pressure (SBP) as a guide for resuscitation can be associated with increased morbidity. The compensatory reserve measurement (CRM) is a novel vital sign based on the recognition that the sum of all mechanisms that contribute to the compensatory response to hemorrhage reside in features of the arterial pulse waveform. Read More

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http://dx.doi.org/10.1111/trf.15632DOI Listing

The use of low-titer group O whole blood is independently associated with improved survival compared to component therapy in adults with severe traumatic hemorrhage.

Transfusion 2020 Jun 1. Epub 2020 Jun 1.

Division of Critical Care Medicine, Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri.

Background: There is a resurgence in the use of low-titer group O whole blood (LTOWB) for hemorrhagic shock. We hypothesized the use of LTOWB compared to component therapy (CT) would be independently associated with improved 24-hour mortality.

Study Design And Methods: In this prospective observational study, trauma patients 18 years of age or older with massive transfusion protocol activations were included from August 17, 2018, to May 14, 2019. Read More

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http://dx.doi.org/10.1111/trf.15696DOI Listing

Early experience with transfusing low titer group O whole blood in the pre-hospital setting in Israel.

Transfusion 2020 Jun 1. Epub 2020 Jun 1.

Surgeon General's HQ, Israel Defense Force, Ramat Gan, Israel.

Background: The Israeli Defense Force Medical Corps (IDF-MC) recently implemented the use of low titer group O whole blood (LTOWB) in the airborne combat search and rescue unit (CSAR) for both military and civilian patients during transport to definitive care. LTOWB is preferentially used by the CSAR instead of red blood cell units and freeze-dried plasma (FDP) for patients with signs of hemorrhagic shock. Ten percent of group O donors were eligible to donate LTOWB as they had anti-A and -B IgM titers of <50. Read More

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http://dx.doi.org/10.1111/trf.15602DOI Listing

From battlefront to homefront: creation of a civilian walking blood bank.

Transfusion 2020 Jun 1. Epub 2020 Jun 1.

Department of Surgery, UT Health San Antonio, San Antonio, Texas.

Hemorrhagic shock remains the leading cause of preventable death on the battlefield, despite major advances in trauma care. Early initiation of balanced resuscitation has been shown to decrease mortality in the hemorrhaging patient. To address transfusion limitations in austere environments or in the event of multiple casualties, walking blood banks have been used in the combat setting with great success. Read More

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http://dx.doi.org/10.1111/trf.15694DOI Listing

The Compensatory Reserve Index Responds to Acute Hemodynamic Changes in Patients with Congenital Heart Disease: A Proof of Concept Study.

Pediatr Cardiol 2020 May 30. Epub 2020 May 30.

Division of Cardiology, Department of Pediatrics, Children's Hospital Colorado, University of Colorado School of Medicine, 13123 East 16th Avenue, B100, Aurora, CO, 80045, USA.

Patients with congenital heart disease (CHD) who undergo cardiac procedures may become hemodynamically unstable. Predictive algorithms that utilize dense physiologic data may be useful. The compensatory reserve index (CRI) trends beat-to-beat progression from normovolemia (CRI = 1) to decompensation (CRI = 0) in hemorrhagic shock by continuously analyzing unique sets of features in the changing pulse photoplethysmogram (PPG) waveform. Read More

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http://dx.doi.org/10.1007/s00246-020-02374-3DOI Listing

HEMOSTATIC POTENTIAL OF COLD-STORED NON-LEUKOREDUCED WHOLE BLOOD OVER TIME: AN ASSESSMENT OF PLATELET FUNCTION AND THROMBIN GENERATION FOR OPTIMAL SHELF-LIFE.

J Trauma Acute Care Surg 2020 May 26. Epub 2020 May 26.

The Center for Translational Injury Research.

Objectives: Cold-stored low-titer whole blood (WB) is becoming increasingly used as the preferred product for initial hemorrhagic shock resuscitation. The purpose of this study was to identify whether the current 21-day shelf-life is the optimal duration for storage of WB, maintaining hemostatic efficacy.

Methods: Five units of fresh low-titer group O WB (non-leukoreduced) were acquired from our regional blood center. Read More

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http://dx.doi.org/10.1097/TA.0000000000002799DOI Listing

Obesity and impaired barrier function after shock: A biometic in vitro model using microfluidics.

J Trauma Acute Care Surg 2020 May 26. Epub 2020 May 26.

Background: Impaired microvascular perfusion in the obese patient has been linked to chronic adverse health consequences. The impact on acute illnesses including trauma, sepsis and hemorrhagic shock (HS) are uncertain. Studies have shown that endothelial glycocalyx and vascular endothelial derangements are causally linked to perfusion abnormalities. Read More

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http://dx.doi.org/10.1097/TA.0000000000002804DOI Listing

Limiting Blood Loss in Orthopaedic Trauma: Strategies and Effects.

Injury 2020 May 11. Epub 2020 May 11.

FRCSC, University of Calgary, Calgary, AB, Canada.

Trauma is a major cause of mortality globally, with post-traumatic hemorrhage being the leading cause of death amongst trauma patients. In this paper, the authors review the underlying pathophysiology of trauma-related hemorrhagic shock, specifically the factors which contribute to the development of the acute coagulopathy of trauma shock (ACoTS). We then review the best available evidence for treatment strategies in the pre-hospital setting, as well as the in-hospital setting. Read More

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http://dx.doi.org/10.1016/j.injury.2020.04.040DOI Listing

The Beneficial Effect of HES on Vascular Permeability and Its Relationship With Endothelial Glycocalyx and Intercellular Junction After Hemorrhagic Shock.

Front Pharmacol 2020 8;11:597. Epub 2020 May 8.

State Key Laboratory of Trauma, Burns and Combined Injury, Shock and Transfusion Department, Research Institute of Surgery, Daping Hospital, Army Medical University, Chongqing, China.

Background: Vascular leakage is a common complication of hemorrhagic shock. Endothelial glycocalyx plays a crucial role in the protection of vascular endothelial barrier function. Hydroxyethyl starch (HES) is a commonly used resuscitation fluid for hemorrhagic shock. Read More

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http://dx.doi.org/10.3389/fphar.2020.00597DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227604PMC

An extracellular cold-inducible RNA-binding protein-derived small peptide targeting triggering receptor expressed on myeloid cells-1 attenuates hemorrhagic shock.

J Trauma Acute Care Surg 2020 Jun;88(6):809-815

From the Center for Immunology and Inflammation, The Feinstein Institutes for Medical Research (S.D.G., M.A., J.C., N-L.D., J.L., W.R., P.W.), Manhasset; Department of Surgery (S.D.G., N-L.D., P.W.), Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead; and Elmezzi Graduate School of Molecular Medicine (M.A., J.C., N-L.D., P.W.), Manhasset, New York.

Background: Extracellular cold-inducible RNA-binding protein (eCIRP) is a damage-associated molecular pattern, which is released into the circulation after hemorrhagic shock (HS). Recently, we discovered that triggering receptor expressed on myeloid cells-1 (TREM-1) serves as a new receptor of eCIRP to exaggerate inflammation. Here, we hypothesize that by inhibiting the interaction between eCIRP and TREM-1 with the use of a novel short peptide derived from human eCIRP known as M3, we can inhibit the inflammatory response and acute lung injury in HS. Read More

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http://dx.doi.org/10.1097/TA.0000000000002664DOI Listing

Establishment of Murine Infection Models with Biological Clones of Dengue Viruses Derived from a Single Clinical Viral Isolate.

Virol Sin 2020 May 25. Epub 2020 May 25.

CAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, 200031, Shanghai, China.

Dengue virus (DENV) is a single-stranded RNA virus transmitted by mosquitoes in tropical and subtropical regions. It causes dengue fever, dengue hemorrhagic fever and dengue shock syndrome in patients. Each year, 390 million people are estimated to be infected by four serotypes of dengue virus, creating a great burden on global public health and local economy. Read More

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http://dx.doi.org/10.1007/s12250-020-00229-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246292PMC

A Review on the Progress and Prospects of Dengue Drug Discovery Targeting NS5 RNA- Dependent RNA Polymerase.

Curr Pharm Des 2020 May 23. Epub 2020 May 23.

Department of Chemistry, School of Science, GITAM (Deemed to be University), Hyderabad 502329, Telangana. India.

Dengue virus (DENV) infection threatens the health and wellbeing of almost 100 million people in the world. Vectored by mosquitoes, DENV may cause severe disease in human hosts called Dengue hemorrhagic fever (DHF)/Dengue shock syndrome (DSS), which are not preventable by any known drug. In the absence of a universally-accepted vaccine, a drug capable of inhibiting DENV multiplication is an urgent and unmet clinical need. Read More

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http://dx.doi.org/10.2174/1381612826666200523174753DOI Listing

Perfusion Index Measurement in Predicting Hypovolemic Shock in Trauma Patients.

J Emerg Med 2020 May 18. Epub 2020 May 18.

Department of Biostatistics, Eskisehir Osmangazi University Faculty of Medicine, Meselik, Eskisehir, Turkey.

Background: Perfusion index (PI) derived from pulse oximeter shows the ratio of the pulsatile blood flow to the nonpulsatile blood flow or static blood in peripheral tissue.

Objectives: The aim of this study was to investigate the relationship between PI and blood transfusion necessity in 24 h and stage of hemorrhagic shock, as well as the utility of PI according to laboratory and clinical parameters, and determining the major risk of hemorrhage.

Methods: PI was measured with a pulse oximeter in 338 patients (235 males, average age 41. Read More

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http://dx.doi.org/10.1016/j.jemermed.2020.04.010DOI Listing

Fibrinogen Activates PAK1/Cofilin Signaling Pathway to Protect Endothelial Barrier Integrity.

Shock 2020 May 18. Epub 2020 May 18.

Shock Trauma Center, University of Maryland School of Medicine, Baltimore, MD.

Introduction: We recently demonstrated that fibrinogen stabilizes syndecan-1 on the endothelial cell (EC) surface and contributes to EC barrier protection, though the intra-cellular signaling pathway remains unclear. P21 (Rac1) activated kinase 1 (PAK1) is a protein kinase involved in intracellular signaling leading to actin cytoskeleton rearrangement and plays an important role in maintaining endothelial barrier integrity. We therefore hypothesized that fibrinogen binding to syndecan-1 activated the PAK1 pathway. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001564DOI Listing

Cardiac Variation of Internal Jugular Vein as a Marker of Volume Change in Hemorrhagic Shock.

Shock 2020 May 18. Epub 2020 May 18.

Department of Acute Medicine, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

Background: Fluid resuscitation, which is critical to counter acute hemorrhagic shock, requires prompt and accurate intravascular volume estimation for optimal fluid administration. This study aimed to evaluate whether cardiac variation of internal jugular vein (IJV), evaluated by ultrasonography, could detect hypovolemic status and predict response to fluid resuscitation.

Methods: Patients undergoing autologous blood transfusion for elective surgery who were prospectively enrolled at the study blood donation center between August 2014 and January 2015. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001548DOI Listing

Prehospital Plasma Transfusion and Survival in Trauma Patients With Hemorrhagic Shock.

JAMA Surg 2020 May 20. Epub 2020 May 20.

SAMU de Paris, Service d'Anesthésie Réanimation, Centre Hospitalier Universitaire Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, and Université Paris Descartes, Paris, France.

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http://dx.doi.org/10.1001/jamasurg.2020.1131DOI Listing

Ruptured Hepatic Artery Aneurysm.

Cureus 2020 Apr 17;12(4):e7715. Epub 2020 Apr 17.

Emergency Medicine, Envision Physician Services, Nashville, USA.

Aneurysmal ruptures are a life-threatening pathology, and while the aorta is the principal location, any aneurysmal rupture can be fatal. Most result from chronic diseases, such as hypertension, diabetes, and vasculitis. Nevertheless, a rupture can result in acute decompensation and must be recognized and addressed quickly to limit morbidity and mortality. Read More

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http://dx.doi.org/10.7759/cureus.7715DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7233937PMC

Mitochondrial-Derived Vesicles Protect Cardiomyocytes Against Hypoxic Damage.

Front Cell Dev Biol 2020 17;8:214. Epub 2020 Apr 17.

State Key Laboratory of Trauma, Burns and Combined Injury, Department 2, Research Institute of Surgery, Daping Hospital, Army Medical University, Chongqing, China.

Myocardial ischemia is a condition with insufficient oxygen supporting the heart tissues, which may result from myocardial infarction or trauma-induced hemorrhagic shock. In order to develop better preventive and therapeutic strategies for myocardial ischemic damage, it is important that we understand the mechanisms underlying this type of injury. Mitochondrial-derived vesicles (MDVs) have been proposed as a novel player in maintaining mitochondrial quality control. Read More

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http://dx.doi.org/10.3389/fcell.2020.00214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212461PMC

Endovascular treatment of a ruptured pararenal abdominal aortic aneurysm in a COVID-19 patient: suggestions and case report.

Ann Vasc Surg 2020 May 15. Epub 2020 May 15.

Vascular Surgery, Department of Clinical-Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy; Vascular Surgery, Department of Surgical Sciences, Teaching Hospital Policlinico S. Matteo, Pavia, Italy.

The aim of this report is to discuss emergent repair for complex aortic diseases in patients affected by novel coronavirus pneumonia (COVID-19), describing a case of ruptured pararenal aortic aneurysm. A COVID-19, eighty-years-old man was admitted for ruptured aneurysm of the pararenal aorta and hemorrhagic shock. Endovascular repair was chosen and a proximal extension of the previous abdominal endograft was performed with parallel stents in the right renal artery and the superior mesenteric artery. Read More

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http://dx.doi.org/10.1016/j.avsg.2020.05.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227555PMC

A novel anti-NS2BNS3pro antibody-based indirect ELISA test for the diagnosis of dengue virus infections.

J Med Virol 2020 May 17. Epub 2020 May 17.

Department of Biotechnology and Bioinformatics, School of Life Sciences, University of Hyderabad, Hyderabad, Telangana State, India.

Dengue virus reportedly circulates as four genetically distinct serotypes for which there is no widely accepted vaccine or drug at present. Morbidity and mortality caused by this virus are alarming for the possible increased threat to human health. A Suitable diagnostic test is the prerequisite for designing and developing control measures. Read More

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http://dx.doi.org/10.1002/jmv.26024DOI Listing

A Coupled Mathematical Model of the Intracellular Replication of Dengue Virus and the Host Cell Immune Response to Infection.

Front Microbiol 2020 29;11:725. Epub 2020 Apr 29.

Center for Functional Genomics of Microbes, Institute of Bioinformatics, University Medicine Greifswald, Greifswald, Germany.

Dengue virus (DV) is a positive-strand RNA virus of the genus. It is one of the most prevalent mosquito-borne viruses, infecting globally 390 million individuals per year. The clinical spectrum of DV infection ranges from an asymptomatic course to severe complications such as dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS), the latter because of severe plasma leakage. Read More

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http://dx.doi.org/10.3389/fmicb.2020.00725DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200986PMC

Contemporary resuscitation of hemorrhagic shock: What will the future hold?

Am J Surg 2020 May 11. Epub 2020 May 11.

University of Maryland School of Medicine, Baltimore, MD, USA. Electronic address:

Resuscitation of the critically ill patient with fluid and blood products is one of the most widespread interventions in medicine. This is especially relevant for trauma patients, as hemorrhagic shock remains the most common cause of preventable death after injury. Consequently, the study of the ideal resuscitative product for patients in shock has become an area of great scientific interest and investigation. Read More

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http://dx.doi.org/10.1016/j.amjsurg.2020.05.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7211588PMC

Renoprotective potential of exogen erythropoietin on experimental ruptured abdominal aortic aneurysm model: An animal study.

Iran J Basic Med Sci 2020 Feb;23(2):271-276

Department of Biochemistry, Faculty of Medicine, Karadeniz Technical University, 61080 Trabzon, Turkey.

Objectives: The aim of this study is to investigate the renoprotective effect of erythropoietin (EPO) on hypovolemic shock and ischemia/reperfusion (IR) injury on kidneys as end-organs in an experimentally-created ruptured abdominal aortic aneurysm (rAAA) model.

Materials And Methods: Thirty anesthetized Sprague-Dawley male rats were randomized to sham ((Sh n:6) (Sh+EPO n:6)) or shock and I/R groups ((S/IR n:9) (S/IR+EPO n:9)). Additional surgical procedure except aortic exploration was not performed on Sh and Sh+EPO groups. Read More

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http://dx.doi.org/10.22038/IJBMS.2019.36215.8626DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7211356PMC
February 2020

Resuscitation with macromolecular superoxide dismutase/catalase mimetic polynitroxylated PEGylated hemoglobin offers neuroprotection in guinea pigs after traumatic brain injury combined with hemorrhage shock.

BMC Neurosci 2020 May 13;21(1):22. Epub 2020 May 13.

Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, 600 North Wolfe Street, Blalock 1404, Baltimore, MD, USA.

Background: Polynitroxylated PEGylated hemoglobin (PNPH, aka SanFlow) possesses superoxide dismutase/catalase mimetic activities that may directly protect the brain from oxidative stress. Stabilization of PNPH with bound carbon monoxide prevents methemoglobin formation during storage and permits it to serve as a carbon monoxide donor. We determined whether small volume transfusion of hyperoncotic PNPH is neuroprotective in a polytrauma model of traumatic brain injury (TBI) plus hemorrhagic shock. Read More

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http://dx.doi.org/10.1186/s12868-020-00571-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222507PMC
May 2020
2.665 Impact Factor

A Rare Case of Spontaneous Bilateral Subcapsular Renal Hematoma.

J Investig Med High Impact Case Rep 2020 Jan-Dec;8:2324709620918098

UCLA-Kern Medical, Bakersfield, CA, USA.

Spontaneous bilateral renal subcapsular hematoma is a rare condition. On literature review, only 2 case reports have elucidated possible etiologies for such a presentation; however, no definite conclusions have been made. We present a rare case of a 52-year-old female with diabetes mellitus type 2, chronic kidney disease stage 4, hypertension, hyperlipidemia, prior traumatic brain injury via motor vehicle accident, who presented to our hospital with diabetic ketoacidosis and clinical signs of pyelonephritis; subsequently, imaging demonstrated spontaneous bilateral renal subcapsular hematoma. Read More

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http://dx.doi.org/10.1177/2324709620918098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223858PMC

An unusual case of dengue shock syndrome complicated by ilio-femoral deep vein thrombosis; a case report.

BMC Infect Dis 2020 May 12;20(1):335. Epub 2020 May 12.

Physician, National Hospital of Sri Lanka, Colombo, Sri Lanka.

Background: Dengue fever is a hemorrhagic fever caused by flaviviruses. Hemorrhagic manifestations are well known to be associated with dengue fever, though the thrombotic events are only seldom reported. Underlying pathophysiology of thrombotic events is multifactorial and the management is challenging due to associated thrombocytopenia and bleeding tendency. Read More

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http://dx.doi.org/10.1186/s12879-020-05062-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216574PMC

Acute kidney injury in dengue among hospitalized children: A prospective view.

Saudi J Kidney Dis Transpl 2020 Mar-Apr;31(2):407-414

Department of Pediatrics, VMMC and Safdarjung Hospital, New Delhi, India.

Dengue viral infection (DVI) has emerged as one of the most common arthropod borne diseases and is more prevalent in the tropical countries. It has varied clinical spectrum ranging from undifferentiated fever to severe hemorrhagic fever and shock with multi-organ dysfunction. Acute kidney injury (AKI) is lesser known complication in DVI. Read More

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http://dx.doi.org/10.4103/1319-2442.284015DOI Listing

[Progress of microcirculation research in shock and sepsis from 2000 to 2019 based on knowledge visualization analysis].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2020 Mar;32(3):287-293

Department of Intensive Care Unit, the Laboratory of Cardiopulmonary Resuscitation and Critical Care Medicine, the Second Affiliated Hospital of Anhui Medical University, Hefei 230601, Anhui, China.

Objective: To explore the progress of microcirculation research in shock and sepsis from 2000 to 2019 based on knowledge visualization analysis.

Methods: The literatures related to microcirculation of shock and sepsis published in Web of Science and Wanfang databases were collected from 2000 to 2019. Then, data collected was sorted out and used to make bar charts and curves reflecting the growth trend of the literatures using Excel software. Read More

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http://dx.doi.org/10.3760/cma.j.cn121430-20200108-00116DOI Listing

Independent Predictors of Mortality for Aeromonas Necrotizing Fasciitis of Limbs: An 18-year Retrospective Study.

Sci Rep 2020 May 7;10(1):7716. Epub 2020 May 7.

Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan.

Necrotizing fasciitis (NF) of the limbs caused by Aeromonas species is an extremely rare and life-threatening skin and soft tissue infection. The purpose of this study was to evaluate the specific characteristics and the independent predictors of mortality in patients with Aeromonas NF. Sixty-eight patients were retrospectively reviewed over an 18-year period. Read More

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http://dx.doi.org/10.1038/s41598-020-64741-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205975PMC

Management of Complex Traumatic Renal Artery-Inferior Vena Cava Fistula: A Case Report and Review of the Literature.

Vasc Endovascular Surg 2020 Jul 6;54(5):449-454. Epub 2020 May 6.

Division of Trauma Surgery & Critical Care, Department of Surgical Disciplines, AIIMS, New Delhi, India.

Background: Renal artery-inferior vena cava (IVC) fistula is usually caused by penetrating injury to the back. However, it is a very rarely reported entity with only 20 cases reported in the literature. They may present acutely with hemodynamic instability or chronically as congestive heart failure. Read More

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http://dx.doi.org/10.1177/1538574420920997DOI Listing

Comparison of 10 vs 14 gauge angiocatheter for treatment of tension pneumothorax and tension induced pulseless electrical activity with hemorrhagic shock: bigger is still better.

J Trauma Acute Care Surg 2020 May 1. Epub 2020 May 1.

Navy Trauma Training Center, LAC+USC Medical Center, Los Angeles, California.

Background: Little is known regarding the effect of hemorrhagic shock on the diagnosis and treatment of tension pneumothorax (tPTX). Recently, the Tactical Combat Casualty Care (TCCC) guidelines included the 10-gauge angiocatheter (10g AC) as an acceptable alternative to the 14g AC. This study sought to compare these two devices for decompression of tPTX and rescue from tension-induced pulseless electric activity (tPEA) in the setting of a concomitant 30% estimated blood volume (EBV) hemorrhage. Read More

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http://dx.doi.org/10.1097/TA.0000000000002724DOI Listing

Incidence of Major Vascular Injuries with Extreme Lateral Interbody Fusion (XLIF).

Authors:
Nancy E Epstein

Surg Neurol Int 2020 18;11:70. Epub 2020 Apr 18.

Adjunct Clinical Professor of Neurological Surgery School of Medicine State University of N.Y. at Stony Brook.

Background: Extreme lateral interbody fusions (XLIF) and minimally invasive (MI) XLIF theoretically offer wide access to the lumbar disc space. The theoretical advantages of XLIF include; minimally disturbing surrounding structures (e.g. Read More

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http://dx.doi.org/10.25259/SNI_113_2020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193196PMC

Curcumin Attenuates Hemorrhagic Shock and Blood Replenish Resuscitation-induced Impairment of Pulmonary Barrier Function by Increasing SIRT1 and Reducing Malondialdehyde and TNF-α Contents and Neutrophil Infiltration in Lung in a Dose-Dependent Fashion.

Transplant Proc 2020 Apr 29. Epub 2020 Apr 29.

School of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan, Republic of China. Electronic address:

Objectives: Acute lung injury (ALI) is a critical complication subsequent to hemorrhage shock and resuscitation (HSR) that frequently leads to multiple organ failure. Collective evidence suggested that the activation of pulmonary nicotinamide adenine dinucleotide-dependent deacetylase sirtuin-1 (SIRT1) plays a critical role in inhibiting the production of reactive oxygen species (ROS) and tumor necrosis factor (TNF)-α, as well as the protection against ALI. Curcumin is a potent activator of SIRT1 and possesses antioxidative and anti-inflammatory effects. Read More

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http://dx.doi.org/10.1016/j.transproceed.2020.01.133DOI Listing

Resuscitative endovascular balloon occlusion of the aorta for retroperitoneal hemorrhage and shock after ipsilateral antegrade angioplasty with vascular closure device.

Ann Transl Med 2020 Mar;8(6):404

Department of Thoracic and Cardiovascular Surgery, Trauma Center, Dankook University Hospital, Cheonan-si, Republic of Korea.

Percutaneous intervention is widely used to treat peripheral vascular disease. Ipsilateral antegrade femoral arterial access for femoropopliteal disease provides a mechanical advantage with regard to wire and stent control; however, it is associated with vascular complications and significant morbidity and mortality secondary to retroperitoneal hemorrhage from a high puncture site or vascular closure device (VCD) failure. Currently, resuscitative endovascular balloon occlusion of the aorta (REBOA) is performed as damage control surgery in patients with non-compressible torso hemorrhage. Read More

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http://dx.doi.org/10.21037/atm.2020.02.47DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186633PMC

Incidence and clinical outcomes of stroke in ST-elevation myocardial infarction and cardiogenic shock.

Catheter Cardiovasc Interv 2020 Apr 30. Epub 2020 Apr 30.

Division of Cardiology, Department of Internal Medicine, Tuft University Medical Center, Boston, Massachusetts, USA.

Objective: The authors sought to evaluate 10-year national trends, incidence and clinical outcomes of stroke in CS-STEMI.

Background: Stroke is a devastating complication among patients with ST-elevation myocardial infarction (STEMI). Concomitant cardiogenic shock (CS) may further increase the risk of stroke. Read More

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http://dx.doi.org/10.1002/ccd.28919DOI Listing

Acute Hemothorax Causing Hemorrhagic Shock Following Small-bore Thoracocentesis in a Patient on Clopidogrel: A Case Report and Literature Review.

Cureus 2020 Mar 27;12(3):e7431. Epub 2020 Mar 27.

Pulmonary Medicine, Marshall University, Joan C. Edwards School of Medicine, Huntington, USA.

Clopidogrel is one of the most commonly prescribed thienopyridines used postcoronary stenting for acute coronary syndrome (ACS). There have been several concerns regarding performing small-bore thoracocentesis on patients on clopidogrel in our practice. We present an 85-year-old male with a history of diabetes, atrial fibrillation, diastolic heart failure, chronic kidney disease (CKD) stage three, who recently had a non-ST elevation myocardial infarction (NSTEMI) requiring a drug-eluting stent (DES) to the left anterior descending (LAD) artery, and was on dual anti-platelet therapy (DAPT). Read More

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http://dx.doi.org/10.7759/cureus.7431DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186085PMC

Practical Considerations for a Military Whole Blood Program.

Mil Med 2020 Apr 30. Epub 2020 Apr 30.

Vitalant, 3636 Blvd of the Allies, Pittsburgh, PA 15213.

Introduction: Prehospital care in the combat environment has always been of great importance to the U.S. military, and trauma resuscitation has remained a cornerstone. Read More

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http://dx.doi.org/10.1093/milmed/usz466DOI Listing

Intrathoracic Pressure Regulator Performance in the Setting of Hemorrhage and Acute Lung Injury.

Mil Med 2020 Apr 30. Epub 2020 Apr 30.

Department of Surgery, University of Cincinnati, 231 Albert Sabin Way ML, Cincinnati, OH 0558.

Introduction: Intrathoracic pressure regulation (ITPR) can be utilized to enhance venous return and cardiac preload by inducing negative end expiratory pressure in mechanically ventilated patients. Previous preclinical studies have shown increased mean arterial pressure (MAP) and decreased intracranial pressure (ICP) with use of an ITPR device. The aim of this study was to evaluate the hemodynamic and respiratory effects of ITPR in a porcine polytrauma model of hemorrhagic shock and acute lung injury (ALI). Read More

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http://dx.doi.org/10.1093/milmed/usz485DOI Listing

Relationship Between Initial Arterial Blood Gases and Coagulation Profiles - Analyzing the Prognosis and Outcomes in Patients with Multiple Injuries/Trauma.

Open Access Emerg Med 2020 15;12:87-92. Epub 2020 Apr 15.

Department of Accident and Emergency Medicine, Faculty of Medicine, Jordan University of Science and Technology, Irbid 22110, Jordan.

Purpose: Trauma is recognized as a significant health concern across the world. The increase in the mortality rate of multiple trauma (MT) patients serves as a major issue for health-care providers. The study investigates the relationship between the initial arterial blood gases and coagulation profiles among the multiple injured/trauma patients. Read More

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http://dx.doi.org/10.2147/OAEM.S244941DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7167264PMC

Emerging hemorrhage control and resuscitation strategies in trauma: endovascular to extracorporeal.

J Trauma Acute Care Surg 2020 Apr 16. Epub 2020 Apr 16.

Department of Surgery, F. Edward Hébert School of Medicine at the Uniformed Services University, Bethesda, MD.

This article reviews four emerging endovascular hemorrhage control and extracorporeal perfusion techniques for management of trauma patients with profound hemorrhagic shock including hemorrhage-induced traumatic cardiac arrest. These include resuscitative endovascular balloon occlusion of the aorta (REBOA), selective aortic arch perfusion (SAAP), extracorporeal life support (ECLS), and emergency preservation and resuscitation (EPR). The pre-clinical and clinical studies underpinning the use of each of these techniques are summarized. Read More

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http://dx.doi.org/10.1097/TA.0000000000002747DOI Listing

Resuscitative Endovascular Balloon of the Aorta is feasible in penetrating chest trauma with major hemorrhage: Proposal of a new institutional deployment algorithm.

J Trauma Acute Care Surg 2020 Apr 27. Epub 2020 Apr 27.

Department of Surgery Riverside University Health Systems. University of California, Riverside, Riverside CA.

Background: Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA) is an emerging option for hemorrhage control, but its use is limited in scenarios such as penetrating chest trauma. The aim of this study was to describe the use of REBOA as a resuscitative adjunct in these cases with major hemorrhage and to propose a new clinical management algorithm.

Methods: This was a prospective, observational study conducted at a single level I trauma center in Colombia. Read More

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http://dx.doi.org/10.1097/TA.0000000000002773DOI Listing

[Essential aspects during the resuscitation of intravascular volume in polytraumatized patients].

Medwave 2020 Apr 23;20(3):e7879. Epub 2020 Apr 23.

Cátedra de Anestesiología y Reanimación, Hospital General Docente Comandante Pinares, San Cristóbal, Cuba. ORCID: 0000-0002-8634-1476.

Trauma is the leading cause of death in the first four decades of life, responsible for 3.5 million deaths a year and carrying a high economic and social impact. Hemorrhagic shock is the consequence of injuries in these patients. Read More

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http://dx.doi.org/10.5867/medwave.2020.03.7879DOI Listing

Reperfusion Repercussions: A Review of the Metabolic Derangements following Resuscitative Endovascular Balloon Occlusion of the Aorta.

J Trauma Acute Care Surg 2020 Apr 22. Epub 2020 Apr 22.

Wake Forest School of Medicine, Winston-Salem, NC Department of Surgery, Wake Forest School of Medicine, Winston-Salem, NC Department of Surgery, University of Michigan, Ann Arbor, MI Department of Surgery, Wake Forest University School of Medicine, Winston-Salem, NC Department of Surgery, Division of Emergency Medicine, University of Utah School of Medicine, Salt Lake City, UT Clinical Investigation Facility, David Grant USAF Medical Center, 101 Bodin Circle, Travis Air Force Base, CA. R Adams Cowley Shock Trauma Center, University of Maryland, Baltimore, Md Bart's Health NHS Trust, Royal London Hospital, Whitechapel, London, United Kingdom; London's Air Ambulance, The Helipad, Royal London Hospital, Whitechapel, London, United Kingdom; NHS Lothian, Department of Anaesthesia, Critical Care and Pain Medicine, Royal Infirmary of Edinburgh, Edinburgh,United Kingdom. Department of Surgery, Division of Emergency Medicine, University of Utah School of Medicine, Salt Lake City, UT.

Introduction: Current Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA) literature focuses on improving outcomes through careful patient selection, diligent catheter placement, and expeditious definitive hemorrhage control. However, the detection and treatment of post-REBOA ischemia-reperfusion injury (IRI) remains an area for potential improvement. Herein we provide a review of the metabolic derangements that we have encountered while managing post-REBOA IRI in past swine experiments. Read More

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http://dx.doi.org/10.1097/TA.0000000000002761DOI Listing

[Vascular injuries during urologic surgery].

Urologe A 2020 Apr 23. Epub 2020 Apr 23.

Klinik für Gefäßchirurgie und Endovaskuläre Chirurgie, St. Antonius Hospital gGmbH Eschweiler, Akademisches Lehrkrankenhaus der RWTH Aachen, Dechant-Deckers-Straße 8, 52249, Eschweiler, Deutschland.

This review article summarizes the epidemiology of vascular injuries during urologic surgery and discusses intraoperative strategies to control bleedings. Techniques of vascular approaches (arteries and veins) are discussed and tricks for vascular repair are explained. Generally, vascular injuries during urologic surgery are rare. Read More

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http://dx.doi.org/10.1007/s00120-020-01207-8DOI Listing

Identification of the miRNA-3185/CYP4A11 axis in cardiac tissue as a biomarker for mechanical asphyxia.

Forensic Sci Int 2020 Jun 13;311:110293. Epub 2020 Apr 13.

Department of Forensic Medicine, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China. Electronic address:

Death by mechanical asphyxia is one of the most difficult conclusions to make in forensic science, especially in corpses displaying slight or no trauma to the surface of the body. Therefore, death by mechanical asphyxia is difficult to prove in medico-legal practice. MicroRNAs (miRNAs) are a class of small, non-coding RNAs involved in the regulation of numerous physiological and pathological cellular processes. Read More

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http://dx.doi.org/10.1016/j.forsciint.2020.110293DOI Listing

Cold-stored whole blood in a Norwegian emergency helicopter service: an observational study on storage conditions and product quality.

Transfusion 2020 Apr 22. Epub 2020 Apr 22.

Department of Immunology and Transfusion Medicine, Haukeland University Hospital, Bergen, Norway.

Background: Increasing numbers of emergency medical service agencies and hospitals are developing the capability to administer blood products to patients with hemorrhagic shock. Cold-stored whole blood (WB) is the only single product available to prehospital providers who aim to deliver a balanced resuscitation strategy. However, there are no data on the safety and in vitro characteristics of prehospital stored WB. Read More

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http://dx.doi.org/10.1111/trf.15802DOI Listing

Acute compartment syndrome due to extravasation of peripheral intravenous blood transfusion.

Saudi J Anaesth 2020 Apr-Jun;14(2):221-223. Epub 2020 Mar 5.

Department of Anesthesiology and Pain Medicine, College of Medicine, Yeungnam University, Daegu, Republic of Korea.

Extravasation is an inadvertent injection or leakage of fluid and drugs in the extravascular or subcutaneous space. The extravasation by massive transfused blood results in the elevation of intra-compartmental pressures. Severely increased pressure may lead to acute compartment syndrome (ACS). Read More

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http://dx.doi.org/10.4103/sja.SJA_565_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7164454PMC