229,479 results match your criteria Shock Distributive


Let's Call It Lung Shock - Or Do We Use the Right Wording?

Respiration 2018 Dec 12:1-2. Epub 2018 Dec 12.

Department of Thoracic Medicine and Surgery, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA.

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December 2018

Crystalloids vs. colloids for fluid resuscitation in the Intensive Care Unit: A systematic review and meta-analysis.

J Crit Care 2018 Nov 30;50:144-154. Epub 2018 Nov 30.

Meridian HealthComms, Plumley Moor Road, Plumley, UK. Electronic address:

Purpose: Guidelines recommend crystalloids for fluid resuscitation in sepsis/shock and switching to albumin in cases where crystalloids are insufficient. We evaluated hemodynamic response to crystalloids/colloids in critically ill adults.

Materials And Methods: The primary research question was: "Are crystalloids sufficient for volume replacement in severe indications (intensive care unit [ICU]/critical illness)?" Randomized, controlled trials (RCTs) were identified using PubMed and EMBASE, and screened against predefined inclusion/exclusion criteria. Read More

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November 2018

Hemodynamic response to β-blockers in severe sepsis and septic shock: A review of current literature.

J Crit Care 2018 Dec 5;50:138-143. Epub 2018 Dec 5.

Department of Critical Care Medicine (707), Radboud university medical center, PO Box 9101, 6500 HB Nijmegen, the Netherlands.

The administration of β-blockers in patients with sepsis is a trending topic in intensive care medicine since the landmark study by Morelli and colleagues, showing a striking decrease in 28-day mortality compared to standard care. While the available evidence suggests that the use of β-blockers in septic shock is safe, the effects on hemodynamics are controversial. In this paper, we review the effect of β-blockade in septic shock on hemodynamics from animal models to critically ill patients. Read More

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December 2018

Evaluating the impact of meloxicam oral suspension administered at parturition on subsequent production, health, and culling in dairy cows: A randomized clinical field trial.

PLoS One 2018 12;13(12):e0209236. Epub 2018 Dec 12.

Solvet Animal Health, Calgary, Alberta, Canada.

Parturition is a painful event experienced by cows at the onset of lactation. This pain could lead to a reduced feed intake, altered metabolic and immunological status, and a host of other diseases that could seriously limit her productive herd lifespan. The objective of the current study was to assess the effect of administration of a single dose of oral meloxicam, a non-steroidal anti-inflammatory drug (NSAID), on the production and health status of cows during their lactation. Read More

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December 2018

[Vibrio cholerae NO-O1/NO-O139 bacteremia in a cirrhotic patient. First case report in Peru and literatura review].

Rev Gastroenterol Peru 2018 Jul-Sep;38(3):301-305

Servicio de Enfermedades Infecciosas y Tropicales, Hospital Nacional Dos de Mayo. Lima, Perú; Facultad de Medicina, Universidad Nacional Mayor de San Marcos. Lima, Perú.

Non-O1, non-O139 Vibrio cholerae (NOVC) strains are an uncommon cause of gastroenteritis. However, they have been recently associated with severe extraintestinal infections in immunocompromised hosts. Among them, bacteremia in cirrhotic patients is noteworthy. Read More

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December 2018

Monitoring haemodynamic response to fluid-challenge in ICU: Comparison of pressure recording analytical method and oesophageal Doppler.

Eur J Anaesthesiol 2018 Dec 11. Epub 2018 Dec 11.

From the Department of Anaesthesia, Burn, and Critical Care, Saint-Louis Lariboisière University Hospital (RB, FD, MR, JS, AM, BGC), Department of Anaesthesia and Critical Care, European Hospital Georges-Pompidou, APHP (AN, DD, RP), Paris Diderot University, Sorbonne Paris Cité (AM, BGC), Inserm U942 (AM), Paris Descartes University, Sorbonne Paris Cité (RP), Inserm U1153 (RP) and Inserm U1160, Paris, France (BGC).

Background: The ability of the pressure recording analytical method (PRAM) in tracking change in cardiac output (ΔCO) after a fluid challenge in ICU needs to be evaluated with the most contemporary comparison methods recommended by experts.

Objective: Our objective was to report the trending ability of PRAM in tracking ΔCO after a fluid challenge in ICU and to compare this with oesophageal Doppler monitoring (ODM).

Design: Prospective, observational study. Read More

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December 2018

Molecular Mechanism of the Cell Membrane Pore Formation Induced by Bubble Stable Cavitation.

J Phys Chem B 2018 Dec 12. Epub 2018 Dec 12.

Microbubbles in combination with ultrasound provides a new and promising way to deliver drugs to living cells. It has been believed that the stable vibration or the collapse of the bubbles under the ultrasound are the two main mechanisms that induce the formation of pores in the cell membrane, through which drugs may get inside the cell cytoplasm. The bubble collapse hypothesis is not only intuitively clear because released shock waves easily penetrate and create pores in the membrane, but also confirmed by both experiment and theory. Read More

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December 2018

Lower Body Negative Pressure: Physiological Effects, Applications, and Implementation.

Physiol Rev 2019 Jan;99(1):807-851

Physiology Section, Otto Loewi Research Center for Vascular Biology, Immunology and Inflammation, Medical University of Graz , Graz , Austria ; Department of Biomedical Physiology and Kinesiology, Simon Fraser University , Burnaby, British Columbia , Canada ; Battlefield Health & Trauma Center for Human Integrative Physiology, Combat Casualty Care Research Program, US Army Institute of Surgical Research, JBSA Fort Sam Houston, Texas.

This review presents lower body negative pressure (LBNP) as a unique tool to investigate the physiology of integrated systemic compensatory responses to altered hemodynamic patterns during conditions of central hypovolemia in humans. An early review published in Physiological Reviews over 40 yr ago (Wolthuis et al. Physiol Rev 54: 566-595, 1974) focused on the use of LBNP as a tool to study effects of central hypovolemia, while more than a decade ago a review appeared that focused on LBNP as a model of hemorrhagic shock (Cooke et al. Read More

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January 2019

Predictors, Burden, and the Impact of Arrhythmia on Patients Admitted for Acute Myocarditis.

Am J Cardiol 2019 Jan 27;123(1):139-144. Epub 2018 Sep 27.

Division of Cardiology, Wayne State University/Detroit Medical Center, Detroit, Michigan.

A significant proportion of patients with acute myocarditis experience sudden cardiac death presumably due to cardiac arrhythmia. In this study, we explore the burden, the predictors of arrhythmia in acute myocarditis and the association between arrhythmias and adverse in-hospital outcomes. After evaluating the frequency of various tachyarrhythmias and bradyarrhythmia in myocarditis population, we built a logistic model to determine the independent predictors of arrhythmias in myocarditis and a 1:1 propensity-matched analysis to examine the impact of arrhythmias. Read More

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January 2019

Management of Acute Gallstone Cholangitis after Roux-en-Y Gastric Bypass with Laparoscopic Transgastric Endoscopic Retrograde Cholangiopancreatography.

Obes Surg 2018 Dec 11. Epub 2018 Dec 11.

Service de Chirurgie Générale et Endocrinienne, CHU Lille, Hôpital Huriez, Rue Michel Polonowski, 59000, Lille, France.

Background: The incidence of biliary lithiasis is increased after bariatric surgery due to rapid weight loss [1]. Trans-oral endoscopic management in cases of common bile duct gallstone complication is not possible in patients with Roux-en-Y gastric bypass (RYGB) due to the modified anatomy. Access to the biliary tree after RYGB with a classical direct surgical approach of common bile duct and choledocoscopy can be used, but may be complicated in situations of acute cholangitis because of the fragility of common duct, or in cases of previous cholecystectomy. Read More

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December 2018

The nucleolar transcriptome regulates Piwi shuttling between the nucleolus and the nucleoplasm.

Chromosome Res 2018 Dec 12. Epub 2018 Dec 12.

Department of Molecular Genetics of the Cell, Institute of Molecular Genetics, Russian Academy of Sciences, 2 Kurchatov Sq., Moscow, Russian Federation, 123182.

The nucleolus contains a lot of proteins unrelated to ribosome biogenesis. Some of these proteins shuttle between the nucleolus and the nucleoplasm regulating the cell cycle and stress response. The piRNA binding protein Piwi is involved in silencing of transposable elements (TEs) in the Drosophila gonads. Read More

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December 2018

Mitochondrial DNA D-Loop Diversity of the Helmeted Guinea Fowls in Kenya and Its Implications on HSP70 Gene Functional Polymorphism.

Biomed Res Int 2018 13;2018:7314038. Epub 2018 Nov 13.

Institute for Biotechnology Research (IBR), Jomo Kenyatta University of Agriculture and Technology (JKUAT), P.O. Box 62000, City Square 00200, Nairobi, Kenya.

We analyzed variations in 90 mitochondrial DNA (mtDNA) D-loop and heat shock protein 70 (HSP70) gene sequences from four populations of domesticated helmeted Guinea fowls (70 individuals) and 1 population of wild helmeted Guinea fowls (20 individuals) in Kenya in order to get information about their origin, genetic diversity, and traits associated with heat stress. 90 sequences were assigned to 25 distinct mtDNA and 4 HSP70 haplotypes. Most mtDNA haplotypes of the domesticated helmeted Guinea fowls were grouped into two main haplogroups, HgA and HgB. Read More

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November 2018

Changes in Transcriptome of IP32953 Grown at 3 and 28°C Detected by RNA Sequencing Shed Light on Cold Adaptation.

Front Cell Infect Microbiol 2018 27;8:416. Epub 2018 Nov 27.

Department of Food Hygiene and Environmental Health, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland.

is a bacterium that not only survives, but also thrives, proliferates, and remains infective at cold-storage temperatures, making it an adept foodborne pathogen. We analyzed the differences in gene expression between IP32953 grown at 3 and 28°C to investigate which genes were significantly more expressed at low temperature at different phases of growth. We isolated and sequenced the RNA from six distinct corresponding growth points at both temperatures to also outline the expression patterns of the differentially expressed genes. Read More

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November 2018

Management of Acquired Hemophilia A in Elderly Patients.

Case Rep Hematol 2018 13;2018:6757345. Epub 2018 Nov 13.

Division of Hematology, Takasago-Seibu Hospital, Takasago 676-0812, Japan.

This report describes six elderly patients with acquired hemophilia A (AHA), including four individuals aged ≥90 years. Bleeding symptoms were subcutaneous or intramuscular hemorrhage (=4), hematuria (=1), and hemorrhagic shock after tooth extraction (=1). Factor VIII (FVIII) activity ranged from <1. Read More

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November 2018

Antibodies to and reproductive health issues in women with SLE: a case-control study.

Lupus Sci Med 2018 21;5(1):e000293. Epub 2018 Nov 21.

Department of Immunology and Allergy, Lausanne University Hospital, Lausanne, Switzerland.

Background: SLE is an autoimmune condition affecting predominantly women. Little is known regarding infection in women with SLE, which may drive autoimmunity and contribute to obstetrical and vascular complications.

Methods: This single-centre, case-control study set primary endpoint in the comparative seropositivity rate to major outer membrane protein (MOMP) and chlamydial heat-shock protein-60 (cHSP60) in age-matched subjects. Read More

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November 2018

Approach of minimal invasive monitoring and initial treatment of the septic patient in emergency medicine.

Open Access Emerg Med 2018 20;10:183-191. Epub 2018 Nov 20.

Emergency Medicine, Universidad del Rosario, Bogotá, Colombia.

Sepsis and septic shock constitute a complex disease condition that requires the engagement of several medical specialties. A great number of patients with this disease are constantly admitted to the emergency department, which warrants the need for emergency physicians to lead in the recognition and early management of septic patients. Timely and appropriate interventions may help reduce mortality in a disease with an unacceptably high mortality rate. Read More

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November 2018

Write a Scientific Paper (WASP): An overview of differences in styles between the sciences and the humanities.

Authors:
Victor Grech

Early Hum Dev 2018 Dec 8. Epub 2018 Dec 8.

University of Malta, Msida, Malta; Mater Dei Hospital, Msida, Malta. Electronic address:

Researchers who cross a discipline may experience culture shock at the different worlds of science and medicine. This paper outlines the differences in concepts and philosophies and in presentation styles. The acute difficulties when attempting to read or write works in different disciplines are also addressed, as well as the differences in perceptions and values when approaching written works in unfamiliar branches of academia. Read More

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December 2018

Frequency of Takotsubo Cardiomyopathy in Adult Patients Receiving Chemotherapy (from a 5-Year Nationwide Inpatient Study).

Am J Cardiol 2018 Nov 24. Epub 2018 Nov 24.

Department of Cardiology, Atlanta VA Medical Center, Decatur, Georgia; Department of Cardiology, Emory University School of Medicine, Atlanta, Georgia. Electronic address:

Takotsubo cardiomyopathy (TC) develops in patients who are under significant emotional, psychosocial, or sudden biochemical stress. However, the added burden of TC on the patients receiving chemotherapy has never been studied. We aimed to describe the additional clinical and economic burden, along with the potential predictors of TC and related in-hospital mortality in patients receiving chemotherapy using the largest inpatient cohort. Read More

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November 2018

Evidence for a protective role for the rs805305 single nucleotide polymorphism of dimethylarginine dimethylaminohydrolase 2 (DDAH2) in septic shock through the regulation of DDAH activity.

Crit Care 2018 Dec 11;22(1):336. Epub 2018 Dec 11.

Institute of Cardiovascular and Medical Sciences, University of Glasgow, University Avenue, Glasgow, G12 8QQ, UK.

Background: Dimethylarginine dimethylaminohydrolase 2 (DDAH2) regulates the synthesis of nitric oxide (NO) through the metabolism of the endogenous inhibitor of nitric oxide synthase, asymmetric dimethylarginine (ADMA). Pilot studies have associated the rs805305 SNP of DDAH2 with ADMA concentrations in sepsis. This study explored the impact of the rs805305 polymorphism on DDAH activity and outcome in septic shock. Read More

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December 2018

Effects of time delay and body temperature on measurements of central venous oxygen saturation, venous-arterial blood carbon dioxide partial pressures difference, venous-arterial blood carbon dioxide partial pressures difference/arterial-venous oxygen difference ratio and lactate.

BMC Anesthesiol 2018 Dec 11;18(1):187. Epub 2018 Dec 11.

Department of Critical Care Medicine, the Affiliated Hospital of Qingdao University, Jiangsu Road 16, Qingdao, 266000, China.

Background: Central venous oxygen saturation (ScvO), venous-arterial blood carbon dioxide partial pressures difference (Pv-aCO), venous-arterial blood carbon dioxide partial pressures difference/arterial-venous oxygen difference ratio (Pv-aCO/Ca-vO) and lactate are important parameters employed during shock resuscitation. We designed this study to confirm the effects of time delay and body temperature on measurements of these four parameters.

Methods: Arterial and central venous blood samples were simultaneously drawn by plastic syringes via indwelling intra-arterial and central venous catheters from critically ill patients. Read More

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December 2018

Regulatory motifs found in the small heat shock protein (sHSP) gene family in tomato.

BMC Genomics 2018 Dec 11;19(Suppl 8):860. Epub 2018 Dec 11.

CIFASIS - CONICET, Ocampo y Esmeralda, Rosario, S2000EZP, Argentina.

Background: In living organisms, small heat shock proteins (sHSPs) are triggered in response to stress situations. This family of proteins is large in plants and, in the case of tomato (Solanum lycopersicum), 33 genes have been identified, most of them related to heat stress response and to the ripening process. Transcriptomic and proteomic studies have revealed complex patterns of expression for these genes. Read More

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December 2018

The influence of running velocity on resultant tibial acceleration in runners.

Sports Biomech 2018 Dec 12:1-11. Epub 2018 Dec 12.

a Sports Performance Research Institute New Zealand (SPRINZ), School of Sport and Recreation , Auckland University of Technology , Auckland , New Zealand.

Tibial acceleration is a surrogate measure for impact loading and might be useful for identifying lower limb fatigue injury in runners. The resultant tibial acceleration calculated from all three axes of a triaxial accelerometer provides a single metric that is independent of the sensor orientation. The purpose of this study was to investigate the relationship between resultant tibial acceleration and running velocity, and to establish a normative database of tibial acceleration profiles. Read More

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December 2018

Shock Tube Measurement of the CH+H<=>CH+H Rate Constant.

J Phys Chem A 2018 Dec 11. Epub 2018 Dec 11.

The rate constant for the reaction CH+H⇒CH+H was studied behind reflected shock waves at temperatures between 1619 and 1948 K and pressures near 10 atm in a mixture of CH, CH, H, and argon. CH time-histories were measured using laser absorption of a CO gas laser near 10.53 microns. Read More

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December 2018

Editorial: Invisible hematoma causing shock after open-heart surgery: Localized cardiac tamponade.

Authors:
Hideaki Kanzaki

J Cardiol Cases 2014 Jun 26;9(6):243-244. Epub 2014 Mar 26.

Department of Cardiovascular Medicine, Heart Failure Division, National Cerebral and Cardiovascular Center, 5-7-1 Fujishiro-dai, Suita, Osaka 565-8565, Japan.

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Acute myocardial infarction due to spontaneous postpartum multi-vessel coronary artery dissection.

J Cardiol Cases 2014 Feb 12;9(2):80-83. Epub 2013 Dec 12.

Department of Cardiology, Imelda Hospital, Bonheiden, Belgium.

Spontaneous coronary artery dissection is a rare cause of myocardial infarction in young, otherwise healthy people. We present a case report of a 37-year-old woman, without cardiovascular risk factors, who survived a major acute myocardial infarction due to multi-vessel spontaneous coronary artery dissection which was complicated by cardiogenic shock in the third week postpartum. She fully recovered with medical therapy in combination with angioplasty. Read More

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February 2014

Anaphylactic shock associated with intravenous amiodarone.

J Cardiol Cases 2014 Feb 12;9(2):61-62. Epub 2013 Dec 12.

Department of Cardiology, Siyami Ersek Cardiovascular and Thoracic Surgery Center, Istanbul, Turkey.

A 64-year-old woman was admitted to our emergency department with shortness of breath and palpitation which started 2 h before her admission. She had a history of rheumatic mitral valve disease and was on drug treatment with warfarin and metoprolol. The patient was orthopneic, blood pressure was 108/68 mmHg with an irregular pulse with a heart rate of 158 beats per minute, and respiratory rate was 23 times per minute. Read More

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February 2014
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Post-operative simultaneous very late two-vessel drug eluting stent thrombosis with sparing of bare metal stent in a Jehovah's witness after clopidogrel withdrawal.

J Cardiol Cases 2014 Feb 13;9(2):57-60. Epub 2013 Dec 13.

Department of Surgery/Anesthesiology, University of South Florida, Tampa, FL, USA.

Very late stent thrombosis is a feared complication after drug-eluting stent (DES) implantation. Several factors related to the patient, generation and type of the deployed stent, procedure, and premature antiplatelet withdrawal are known to contribute to this complication. Herein, we describe a case of a Jehovah's witness patient who developed simultaneous two-vessel 1st generation DES thrombosis 5. Read More

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February 2014

Delayed post-operative cardiac tamponade manifesting as cardiogenic shock.

J Cardiol Cases 2013 Dec 2;8(6):195-197. Epub 2013 Nov 2.

Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN, USA.

We describe the case of a 32-year-old woman with a history of cardiac surgery two weeks previously who presented with an upper gastrointestinal bleed. She also had symptoms of syncope and abdominal pain, as well as elevated liver enzymes. She had cool, clammy extremities, bilateral lower extremity edema, and oliguria. Read More

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December 2013

Stress-induced cardiomyopathy accompanied by heat stroke.

J Cardiol Cases 2015 Jul 1;12(1):16-19. Epub 2015 May 1.

Department of Cardiology, Takeda General Hospital, Kyoto, Japan.

Heat stroke is a severe illness characterized by a core temperature >40 °C (104 °F) and central nervous system abnormalities, such as delirium, convulsions, or coma, resulting from exposure to environmental heat or strenuous physical experience. We describe a case with high body temperature and coma, who also presented with wide QRS tachycardia and shock. He was initially treated for heat stroke and wide QRS tachycardia. Read More

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Transcatheter mitral paravalvular leakage closure: A beautiful last resort.

J Cardiol Cases 2014 Oct 23;10(4):147-149. Epub 2014 Jul 23.

Department of Cardiology, St. Antonius Hospital, Nieuwegein, The Netherlands.

We describe a case of a 54-year-old patient with rheumatic heart valve disease who was treated with double valve replacement (both aortic and mitral) twice. Two months after the second operation she developed a severe mitral paravalvular leakage (PVL) leading to cardiogenic shock for which she was hospitalized in the intensive care unit. Multiple weaning efforts proved to be unsuccessful because of persistent hemodynamic instability caused by the severe PVL. Read More

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October 2014

Impella 2.5 in a patient with left main coronary artery occlusion.

J Cardiol Cases 2013 May 5;7(5):e142-e144. Epub 2013 Mar 5.

Department of Cardiac Surgery, Deutsches Herzzentrum Berlin (DHZB, German Heart Institute Berlin), Berlin, Germany.

Short-term assist devices have been indicated in many clinical settings mostly as a bridge to the next step. In this article, we report a case of cardiogenic shock due to acute occlusion of left main coronary artery who was scheduled to be transferred from Iran to Germany for the next treatment (permanent assist device implantation). Impella 2. Read More

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Kounis-Zavras syndrome presenting with ventricular arrhythmias and cardiogenic shock.

J Cardiol Cases 2013 Mar 5;7(3):e74-e77. Epub 2012 Dec 5.

Cardiovascular Institute, Azienda Ospedaliero-Universitaria S. Anna di Ferrara, Ferrara, Italy.

In this case report we describe a case of the Kounis-Zavras syndrome (coincidental occurrence of chest pain and allergic reactions accompanied by clinical and laboratory findings of cardiac ischemia). A 34-year-old woman presented to the emergency unit with severe chest pain from 2 h. She reported a medical history of asthma. Read More

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Cardiogenic shock due to takotsubo cardiomyopathy associated with serotonin syndrome.

J Cardiol Cases 2013 Jan 19;7(1):e1-e3. Epub 2012 Aug 19.

Department of Cardiology, Yokohama Rosai Hospital, 3211 Kozukue-cho, Kohoku-ku, Yokohama 222-0036, Japan.

A 65-year-old woman, with valvular heart disease, atrial fibrillation, and depression, presented to the emergency room due to dyspnea with shock state accompanied by agitation. An electrocardiogram showed ST segment elevation in leads II, III, aV, I, aV, and V. An echocardiography revealed extensive akinesis in the apex, but hyperkinesis in the base, with apical ballooning appearance. Read More

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January 2013

Intra-aortic balloon pump induced dynamic left ventricular outflow tract obstruction and cardiogenic shock after very late stent thrombosis in the left anterior descending coronary artery.

J Cardiol Cases 2012 Nov 9;6(5):e137-e140. Epub 2012 Aug 9.

Department of Cardiology and Nephrology, Mie University Graduate School of Medicine, Tsu, Japan.

An 81-year-old woman had undergone percutaneus coronary intervention to mid left anterior descending coronary artery with a drug-eluting stent for effort angina pectoris. Although she had remained asymptomatic for 3 years, she developed cardiogenic shock following acute myocardial infarction due to stent thrombosis. Her condition deteriorated despite successful revascularization and an initiation of intra-aortic balloon pump (IABP). Read More

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November 2012

Postinfarct cardiac free wall rupture detected by multidetector computed tomography.

J Cardiol Cases 2012 Jun 18;5(3):e147-e149. Epub 2012 Apr 18.

Department of Cardiovascular Surgery, Chikamori Hospital Heart Center, Kochi, Japan.

Cardiac free wall rupture after myocardial infarction is one of the life-threatening complications, which often results in sudden onset of cardiogenic shock caused by cardiac tamponade. Multidetector computed tomography (MDCT) provides valuable information in any clinical setting. There have been a few case reports on detecting cardiac rupture by means of CT. Read More

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Simultaneous stent obstruction of triple vessels with very late stent thrombosis after implantation of sirolimus-eluting stents.

J Cardiol Cases 2012 Apr 16;5(2):e87-e91. Epub 2012 Mar 16.

Department of Cardiology, Nagoya Medical Center, 4-1-1 San-no-maru, Naka-ku, Nagoya 460-0001, Japan.

A 70-year-old man presented to the emergency department at our hospital with chest pain, 24 months after sirolimus-eluting stents (SESs) were implanted in the proximal left anterior descending coronary artery (LAD), middle right coronary artery (RCA), and middle left circumflex artery (LCX), respectively. Electrocardiogram showed complete right bundle branch block and ST-segment elevation in leads II, III, and aVF. He suddenly went to ventricular tachycardia, followed by ventricular fibrillation. Read More

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Rupture of pseudoaneurysm of the pancreaticoduodenal arcade after acute aortic dissection in a patient on anticoagulant therapy.

J Cardiol Cases 2011 Apr 13;3(2):e103-e105. Epub 2011 Jan 13.

Division of Cardiology, Department of Internal Medicine, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo 181-8611, Japan.

An 81-year-old woman on anticoagulant therapy after mechanical heart valve replacement was admitted because of acute aortic dissection. Anticoagulant therapy had to be continued with heparin even after admission. Gastrointestinal hemorrhage occurred suddenly and she developed hemorrhagic shock. Read More

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Transient left ventricular dysfunction associated with severe infection.

J Cardiol Cases 2011 Apr 18;3(2):e78-e81. Epub 2011 Feb 18.

Division of Cardiology, Niigata University School of Medical and Dental Sciences, Niigata, Japan.

infection, although commonly seen as pneumonia, can also manifest systemic involvement. Here, we describe a case of sporadic infection coinciding with pneumonia, rhabdomyolysis, renal failure, and severe left ventricular dysfunction, which subsequently developed refractory septic shock. An endomyocardial biopsy revealed no findings of interstitial inflammatory infiltrates. Read More

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Subacute coronary occlusion with dissection of the sinus of Valsalva after percutaneous coronary intervention in the right coronary artery.

J Cardiol Cases 2011 Feb 14;3(1):e13-e16. Epub 2010 Dec 14.

Division of Cardiology, East Medical Center Higashi Municipal Hospital City of Nagoya, 1-2-23 Wakamizu, Chikusa-ku, Nagoya 464-8547, Japan.

Subacute coronary occlusion due to dissection of the right coronary sinus of Valsalva after coronary stenting at the proximal portion of the right coronary artery is described. A bail-out procedure was successfully performed by stent deployment at the ostium of the right coronary artery with its proximal edge protruding into the ascending aorta. However, the patient died of multiple organ failure due to worsened renal failure and cardiogenic shock. Read More

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February 2011

Cre-miR914-regulated RPL18 is involved with UV-B adaptation in Chlamydomonas reinhardtii.

J Plant Physiol 2018 Nov 22;232:151-159. Epub 2018 Nov 22.

Key Laboratory of Algal Biology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, 430072, China. Electronic address:

UV radiation is a serious threat to life, and algae have developed highly efficient adaptations to UV radiation through the course of evolution. To date, studies investigating the mechanisms of UV adaptation in algae have focused on physiological regulation and associated protein coding genes, with only a few reports on associated protein non-coding genes. In a previous study, we found that Cre-miR914 was significantly down-regulated in Chlamydomonas reinhardtii in response to heat shock. Read More

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November 2018

Prognostic implications of markers of the metabolic phenotype in human cutaneous melanoma.

Br J Dermatol 2018 Dec 7. Epub 2018 Dec 7.

Instituto de Investigación Hospital 12 de Octubre, Universidad Complutense de Madrid, Madrid, Spain.

Background: Reprogramming of energy metabolism to enhanced aerobic glycolysis has been defined as a hallmark of cancer.

Objective: To investigate the role of the mitochondrial proteins, β-subunit of the H -ATP synthase (β-F1-ATPase), and heat-shock protein 60 (HSP60), and the glycolytic markers, glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and pyruvate kinase M2 (PKM2), as well as the bioenergetic cellular (BEC) index, in melanoma progression.

Material And Methods: The expression of energy metabolism proteins were assessed on a set of different melanoma cells representing the natural biological history of the disease: primary cultures of melanocytes, radial (WM35) and vertical (WM278) growth phases, and poorly (C81-61-PA) and highly (C8161-HA) aggressive melanoma cells. Read More

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December 2018
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PML/RARA inhibits expression of HSP90 and its target AKT.

Br J Haematol 2018 Dec 9. Epub 2018 Dec 9.

Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy.

Essential for cell survival, the 90 kD Heat Shock Proteins (HSP90) are molecular chaperons required for conformational stabilization and trafficking of numerous client proteins. Functional HSP90 is required for the stability of AKT, a serine-threonine kinase phosphorylated in response to growth factor stimulation. AKT plays a crucial regulatory role in differentiation, cell cycle, transcription, translation, metabolism and apoptosis. Read More

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December 2018

Liberal versus conservative fluid therapy in adults and children with sepsis or septic shock.

Cochrane Database Syst Rev 2018 Dec 10;12:CD010593. Epub 2018 Dec 10.

Intensive Care Unit, Second Affiliated Hospital Medical College, Zhejiang University, 88 Jiefang Road, Hangzhou, China, 310009.

Background: Sepsis and septic shock are potentially life-threatening complications of infection that are associated with high morbidity and mortality in adults and children. Fluid therapy is regarded as a crucial intervention during initial treatment of sepsis. Whether conservative or liberal fluid therapy can improve clinical outcomes in patients with sepsis and septic shock remains unclear. Read More

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December 2018
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Pro-Inflammatory Actions of Red Blood Cell-Derived DAMPs.

Authors:
Viktória Jeney

Exp Suppl 2018 ;108:211-233

Faculty of Medicine, Department of Internal Medicine, University of Debrecen, Debrecen, Hungary.

Damage-associated molecular patterns (DAMPs) or alarmins are endogenous danger signals that are derived from damaged cells and extracellular matrix degradation, capable of triggering innate immune response to promote tissue damage repair. Hemolytic or hemorrhagic episodes are often associated with inflammation, even when infectious agents are absent, suggesting that damaged red blood cells (RBCs) release DAMPs.Hemoglobin (Hb) composes 96% of the dry weight of RBCs; therefore upon hemolysis, tremendous amounts of Hb are released into the extracellular milieu. Read More

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January 2018
2 Reads

Effects of the timing of administration of IgM- and IgA-enriched intravenous polyclonal immunoglobulins on the outcome of septic shock patients.

Ann Intensive Care 2018 Dec 10;8(1):122. Epub 2018 Dec 10.

Department of Anesthesia, Resuscitation and Pain Therapy, Cattinara Hospital, University of Trieste, Strada di Fiume 447, 34149, Trieste, Italy.

Background: The administration of endovenous immunoglobulins in patients with septic shock could be beneficial and preparations enriched with IgA and IgM (ivIgGAM) seem to be more effective than those containing only IgG. In a previous study Berlot et al. demonstrated that early administration of ivIgGAM was associated with lower mortality rate. Read More

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December 2018

Impact of hemoperfusion with polymyxin B added to hemofiltration in patients with endotoxic shock: a case-control study.

Ann Intensive Care 2018 Dec 7;8(1):121. Epub 2018 Dec 7.

Critical Care Center, Parc Tauli Hospital Universitari, Institut d'Investigació i Innovació Parc Taulí I3PT, Universitat Autònoma de Barcelona, Sabadell, Spain.

Background: Septic shock is a leading cause of death in critical patients. In patients with gram-negative septic shock, hemoperfusion with polymyxin B aims to remove endotoxins from plasma. We analyzed the clinical and biological response to hemoperfusion in patients with septic shock and acute kidney injury. Read More

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December 2018

An unusual case of pulmonary fat embolism following blunt trauma.

Forensic Sci Med Pathol 2018 Dec 7. Epub 2018 Dec 7.

Institute of Forensic Medicine, University of Belgrade - School of Medicine, 31a Deligradska str, Belgrade, 11000, Serbia.

Fat embolism is markedly underdiagnosed, even though it is a well-known phenomenon following fractures of the long bones, injury to subcutaneous fat tissue, rupture of a fatty liver, surgical operations on fatty tissues, septicemia, burns and barotrauma. Forensic pathologists tend to "simplify" autopsy report conclusion in cases with multiple injuries where fat embolism and exsanguination could be considered to be the concomitant causes of death. Herein we present a case of 24-year-old male who was beaten with a metal rod by several persons. Read More

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December 2018
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Effects of crystalloids and colloids on microcirculation, central venous oxygen saturation, and central venous-to-arterial carbon dioxide gap in a rabbit model of hemorrhagic shock.

J Anesth 2018 Dec 10. Epub 2018 Dec 10.

Department of Cardiovascular Surgery, Tokyo Women's Medical University, 8-1, Kawadacho Shinjuku-ku, Tokyo, 162-8666, Japan.

Objective: The effects of hydroxyethyl starch (HES) on microcirculation, central venous oxygen saturation (ScvO), and the central venous-to-arterial carbon dioxide gap (dCO) are studied in a rabbit model of hemorrhagic shock for elucidating the advantages and drawbacks of resuscitation with HES compared with crystalloids.

Methods: An ear chamber and sublingual mucosa were used to examine blood vessels by intravital microscopy. Hemorrhagic shock was induced by removing nearly half of the blood volume. Read More

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December 2018

Impact of individualized target mean arterial pressure for septic shock resuscitation on the incidence of acute kidney injury: a retrospective cohort study.

Ann Intensive Care 2018 Dec 10;8(1):124. Epub 2018 Dec 10.

Multidisciplinary Epidemiology and Translational Research in Intensive Care (METRIC), Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.

Background: To examine the relationship between delta mean arterial pressure (ΔMAP; MAP change between pre-admission minus post-resuscitation) and acute kidney injury (AKI) among patients with septic shock. In this retrospective, single-center cohort study of adult patients pre-admission MAP is defined as the median MAP recorded from 365 to 7 days before admission. Post-resuscitation MAP was median MAP during the 7th hour after initiating resuscitation. Read More

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December 2018
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Prognostic value of sepsis-induced coagulation abnormalities: an early assessment in the emergency department.

Intern Emerg Med 2018 Dec 7. Epub 2018 Dec 7.

High-Dependency Unit, Department of Clinical and Experimental Medicine, Azienda Ospedaliero-Universitaria Careggi, Lg. Brambilla 3, 50134, Florence, Italy.

To evaluate if the assessment of coagulation abnormalities at ED admission could improve prognostic assessment of septic patients. This report utilizes a portion of the data collected in a prospective study, with the aim to identify reliable biomarkers for an early sepsis diagnosis. In the period November 2011-December 2016, we enrolled 268 patients, admitted to our High-Dependency Unit with a diagnosis severe sepsis/septic shock. Read More

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December 2018