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    1 OF 244

    Role of mitral valve repair in active infective endocarditis: long term results.
    J Cardiothorac Surg 2017 May 18;12(1):29. Epub 2017 May 18.
    Cardiochirurgia, AOU Careggi Firenze, Florence, Italy.
    Background: Although mitral valve repair is at present the technique of choice in mitral regurgitation (MR) due to degenerative valve disease, long term results in patients with active mitral infective endocarditis (IE) are still under evaluation.

    Methods: In the study were included 34 consecutive patients (22 males; mean age, 60 years; range 32-84 years) referred to our institution between January 1, 2005 to December 31, 2011 who were treated with valve repair for mitral valve (MV) active infective endocarditis. Eighteen patients underwent isolated MV repair. Read More

    Aeromedical Evacuation Using Extra Corporeal Life Support After Resuscitated Cardiac Arrest.
    Aerosp Med Hum Perform 2017 Apr;88(4):431-433
    Medic'Air International, Bagnolet, France.
    Background: Extra corporeal life support (ECLS) is presently first line therapy for refractory cardiogenic shock. Mobile circulatory support teams implant ECLS or extra corporeal membrane oxygenation (ECMO) in patients in the hospital without circulatory support. These patients are then transported to specialized centers. Read More

    Impact and Management of Left Ventricular Function on the Prognosis of Takotsubo Syndrome.
    Eur J Clin Invest 2017 May 18. Epub 2017 May 18.
    First Department of Medicine, Faculty of Medicine, University Medical Centre Mannheim (UMM), University of Heidelberg, Mannheim, Germany.
    Aims: Early research has proposed that patients with Takotsubo syndrome (TTS) could have a higher mortality rate than the general population. Our study was conducted to determine the short- and long-term outcome of TTS patients associated with a significantly compromised left ventricular function on hospital admission.

    Methods And Results: Our institutional database constituted a collective of 112 patients diagnosed with TTS between 2003 and 2015. Read More

    Cardiogenic Shock, Acute Severe Mitral Regurgitation and Complete Heart Block After Cavo-Tricuspid Isthmus Atrial Flutter Ablation.
    Cardiol Res 2017 Apr 3;8(2):63-67. Epub 2017 May 3.
    Wright State University Boonshoft School of Medicine, Dayton, OH, USA.
    Radiofrequency (RF) ablation is the first-line management of cavo-tricuspid isthmus dependent atrial flutter. It has been performed with 95% success rate. Adverse events are very rare. Read More

    Veno-arterial extracorporeal membrane oxygenation as cardiogenic shock therapy support in adult patients after heart surgery.
    Kardiochir Torakochirurgia Pol 2017 Mar 31;14(1):32-36. Epub 2017 Mar 31.
    Department of Anesthesiology and Intensive Therapy, Jagiellonian University Medical College, John Paul II Hospital, Kraków, Poland.
    Introduction: The authors present their personal experience in qualifying and treating adult patients using veno-arterial (VA) extracorporeal membrane oxygenation (ECMO) in postcardiotomy cardiogenic shock.

    Aim: The aim of this study was to analyze the results of VA ECMO in patients with postcardiotomy cardiogenic shock. An analysis of the risk factors of postoperative mortality was also performed. Read More

    Gender-based Assessment of Survival in Trauma-hemorrhagic Shock: A Retrospective Analysis of Indian Population.
    Indian J Crit Care Med 2017 Apr;21(4):218-223
    Department of Emergency Medicine, All India Institute of Medical Sciences, New Delhi, India.
    Introduction: Trauma-hemorrhagic shock (THS) is a leading cause of death. Female rats and women experience better outcomes in terms of survival after major trauma as compared to males. There are limited data in Indian population. Read More

    ST-segment elevation myocardial infarction could be the primary presentation of acute aortic dissection.
    Am J Emerg Med 2017 May 11. Epub 2017 May 11.
    Department of Cardiology, The Second Xiangya Hospital of Central South University, Changsha, China. Electronic address:
    Background: Stanford type A aortic dissection (TAAD) may lead to coronary artery occlusion and malfunction. However, TAAD manifesting as acute ST-segment elevation myocardial infarction (STEMI) has not been studied. In the present study, we reported 8 TAAD cases with STEMI as the primary presentation, and analyzed their clinical characteristics and outcome. Read More

    Impact of chronic obstructive pulmonary disease on in-hospital morbidity and mortality in patients with ST-segment elevation myocardial infarction treated by primary percutaneous coronary intervention.
    Int J Cardiol 2017 May 11. Epub 2017 May 11.
    University of Medicine and Pharmacy of Tîrgu Mureș, 540139 Tîrgu Mureș, Romania. Electronic address:
    Background: Patients with chronic obstructive pulmonary disease (COPD) presenting with ST-segment elevation myocardial infarction (STEMI) are less likely to beneficiate of primary percutaneous coronary intervention (pPCI), and have poorer prognosis. We aimed to evaluate the impact of COPD on the in-hospital outcomes of pPCI-treated STEMI patients.

    Methods: Data were collected from 418 STEMI patients treated by pPCI. Read More

    A Critical Note on Treatment of a Severe Diltiazem Intoxication; High-Dose Calcium and Glucagon Infusions.
    Basic Clin Pharmacol Toxicol 2017 May 15. Epub 2017 May 15.
    Department of Pharmacy, Franciscus Gasthuis hospital, Rotterdam, The Netherlands.
    The morbidity and mortality of a severe calcium channel blocker intoxication is high due to serious toxic cardiac effects. Its treatment is supported by low-quality evidence from heterogeneous literature. We describe a case of a severe diltiazem intoxication and critically appraise the efficacy and role of high-dose calcium and glucagon infusions. Read More

    First-Line Support by Intra-Aortic Balloon Pump in Non-Ischaemic Cardiogenic Shock in the Era of Modern Ventricular Assist Devices.
    Cardiology 2017 May 13;138(1):1-8. Epub 2017 May 13.
    Objectives: Little is known about circulatory support in cardiogenic shock (CS) from other causes than the acute coronary syndrome or after cardiotomy. We evaluated the effects of first-line intra-aortic balloon pump (IABP) support in this subpopulation of CS patients.

    Methods: A retrospective study was performed in 27 patients with CS from end-stage cardiomyopathy supported firstly by IABP in the years 2011-2016. Read More

    A 0h/1h protocol for safe early discharge of chest pain patients.
    Acad Emerg Med 2017 May 13. Epub 2017 May 13.
    Lund University, Skåne University Hospital, Department of Internal and Emergency Medicine, Lund, Sweden.
    Objectives: Guidelines recommend a 0h/1h high-sensitivity cardiac troponin T (hs-cTnT) diagnostic strategy in acute chest pain patients. There is however little data on the performance of this strategy when combined with clinical risk stratification. We aimed to evaluate the diagnostic accuracy of an accelerated diagnostic protocol (ADP) using the 0h/1h hs-cTnT strategy together with an adapted Thrombolysis In Myocardial Infarction (TIMI) score and ECG for ruling out major adverse cardiac events (MACE) within 30 days. Read More

    Percutaneous Mechanical Circulatory Support Devices in Cardiogenic Shock.
    Circ Cardiovasc Interv 2017 May;10(5)
    From the Duke Clinical Research Institute, Durham, NC.
    Despite a high rate of early revascularization and use of intra-aortic balloon pump counterpulsation therapy, the prognosis of patients with cardiogenic shock has remained poor. In the hopes of improving outcomes, clinicians are increasingly turning to percutaneous left and right mechanical circulatory support devices. Until recently, the evidence base for these devices had consisted only of observational data, meta-analyses, and small feasibility trials. Read More

    Early versus Late Percutaneous Revascularization in Patients Hospitalized with Non ST-Segment Elevation Myocardial Infarction: The Atherosclerosis Risk in Communities (ARIC) Surveillance Study.
    Catheter Cardiovasc Interv 2017 May 12. Epub 2017 May 12.
    Division of Cardiology, University of North Carolina at Chapel Hill, Chapel Hill, NC.
    Background: Current guidelines recommend early invasive intervention (<24 hours) for high risk patients with non-ST-segment elevation myocardial infarction (NSTEMI). A delayed invasive strategy (24-72 hours) is considered reasonable for low risk patients. The real-world effectiveness of this strategy is unknown. Read More

    Percutaneous left atrial decompression in adults with refractory cardiogenic shock supported with veno-arterial extracorporeal membrane oxygenation.
    J Card Surg 2017 May 11. Epub 2017 May 11.
    Division of Cardiology, Peter Munk Cardiac Centre, University Health Network, Toronto, Ontario.
    Background And Aim Of The Study: Left ventricular (LV) distention, a recognized complication in patients supported with veno-arterial extracorporeal membrane oxygenation (VA-ECMO) for refractory cardiogenic shock, can lead to pulmonary edema, increased myocardial oxygen consumption, and LV thrombus formation. Atrial septostomy was examined as a management strategy for LV distension.

    Methods: Of 72 patients supported with VA-ECMO, seven patients underwent atrial septostomy through a trans-septal approach. Read More

    Atrial Septostomy for Left Atrial Decompression During Extracorporeal Membrane Oxygenation by Inoue Balloon Catheter.
    Circ J 2017 May 11. Epub 2017 May 11.
    Division of Cardiovascular Medicine, Department of Medicine, China Medical University Hospital.
    Background: Refractory pulmonary edema is an infrequent but serious complication in patients receiving venoarterial extracorporeal membrane oxygenation (VA-ECMO) for myocardial failure. Left atrial (LA) decompression in this setting is important. Although a few methods have been reported, the experience is mostly limited to children. Read More

    A Survival Case of Fulminant Right-Side Dominant Eosinophilic Myocarditis.
    Int Heart J 2017 May 12. Epub 2017 May 12.
    Department of Cardiology and Nephrology, Mie University Graduate School of Medicine.
    A 59-year-old Japanese woman was admitted to a nearby hospital with dyspnea and general malaise. Transthoracic echocardiography revealed right ventricular (RV) dilatation with severely reduced systolic function and leftward shift of the intraventricular septum. She was initially diagnosed with acute right heart failure, and fell into cardiogenic shock requiring an intra-aortic balloon pump and inotropic agents. Read More

    Prognostic Factors for In-Hospital and Long-Term Survival in Patients with Acute ST-Segment Elevation Myocardial Infarction after Percutaneous Coronary Intervention.
    Tohoku J Exp Med 2017 05;242(1):27-35
    Department of Cardiology, The First Affiliated Hospital of Anhui Medical University.
    Acute ST segment elevation myocardial infarction (STEMI) is one of the causes of death and disability in patients with cardiovascular diseases. This study aimed to investigate the prognostic factors of in-hospital and long-term survival in patients with acute STEMI undergoing percutaneous coronary intervention (PCI). Patients with STEMI undergoing PCI were divided into the death group (n = 54) and the survival group (n = 306) based on the outcomes during hospitalization. Read More

    Morbidity and Mortality Associated With Balloon Aortic Valvuloplasty: A National Perspective.
    Circ Cardiovasc Interv 2017 May;10(5)
    From the Department of Cardiovascular Diseases (M.A., C.J.Z., M.S., R.A.N., M.F.E., V.T.N., G.S.S., R.G., D.R.H., C.S.R.) and Division of Cardiac Surgery, Department of Surgery (K.L.G.), Mayo Clinic College of Medicine, Rochester, MN; and Division of Cardiovascular Diseases, Department of Medicine, Temple University School of Medicine, Philadelphia, PA (R.B.).
    Background: The introduction of transcatheter aortic valve replacement (TAVR) led to renewed interest in balloon aortic valvuloplasty (BAV). We sought to assess contemporary trends in BAV utilization and their outcomes.

    Methods And Results: The Nationwide Inpatient Sample was used to identify patients who underwent BAV between 2004 and 2013. Read More

    Evolution of Australian Percutaneous Coronary Intervention (from the Melbourne Interventional Group [MIG] Registry).
    Am J Cardiol 2017 Apr 12. Epub 2017 Apr 12.
    Department of Cardiology, Royal Melbourne Hospital, Melbourne, Australia; Department of Medicine, University of Melbourne, Melbourne, Australia; Centre of Cardiovascular Research and Education in Therapeutics (CCRET), Monash University, Melbourne, Australia. Electronic address:
    Percutaneous coronary intervention (PCI) continues to evolve with shifting patient demographics, treatments, and outcomes. We sought to document the specific changes observed over a 9-year period in a contemporary Australian PCI cohort. The Melbourne Interventional Group is an established multicenter PCI registry in Melbourne, Australia. Read More

    Effects of Low-Dose Recombinant Human Brain Natriuretic Peptide on Anterior Myocardial Infarction Complicated by Cardiogenic Shock.
    Braz J Cardiovasc Surg 2017 Mar-Apr;32(2):96-103
    Heart Center, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, P.R. China.
    Introduction:: The mortality due to cardiogenic shock complicating acute myocardial infarction (AMI) is high even in patients with early revascularization. Infusion of low dose recombinant human brain natriuretic peptide (rhBNP) at the time of AMI is well tolerated and could improve cardiac function.

    Objective:: The objective of this study was to evaluate the hemodynamic effects of rhBNP in AMI patients revascularized by emergency percutaneous coronary intervention (PCI) who developed cardiogenic shock. Read More

    Increasing Levels of Positive End-expiratory Pressure Improve the Left Ventricular Strain.
    J Thorac Imaging 2017 May 9. Epub 2017 May 9.
    *Intensive Care Medicine, University of Jaén †Statistical Support, Almería ‡Department of Medicine, University of Granada, Spain.
    Purpose: The goal of this study was to evaluate possible changes in the left myocardial performance of patients with cardiogenic shock (CS) during ascending levels of positive end-expiratory pressure (PEEP) using speckle-tracking echocardiography.

    Materials And Methods: This was an interventional clinical study performed on CS patients under mechanical ventilation. These patients underwent echocardiography after 15 to 30 minutes of progressive increases in PEEP (ZEEP, PEEP 5, PEEP 10, PEEP 15 cm H2O). Read More

    Trends in sex differences in clinical characteristics, treatment strategies, and mortality in patients with ST-elevation myocardial infarction in Poland from 2005 to 2011.
    Coron Artery Dis 2017 May 5. Epub 2017 May 5.
    a2nd Cardiology Clinic bDepartment of Interventional Cardiology, Swietokrzyskie Cardiology Center cInstitute of Medical Sciences dInstitute of Nursing and Obstetrics, The Faculty of Medicine and Health Sciences, The Jan Kochanowski University, Kielce e3rd Department of Cardiology, School of Medicine with the Division of Dentistry in Zabrze, Silesian Centre for Heart Diseases, Medical University of Silesia in Katowice, Zabrze, Poland.
    Introduction: During the last decade, there has been an increased awareness of sex differences in the clinical characteristics, management, and mortality in myocardial infarction. Many previous studies have found that women with ST-elevation myocardial infarction (STEMI) have a poorer baseline risk profile, are less intensively treated, and have worse outcomes.

    Objective: To evaluate whether sex disparities in STEMI have changed in recent years. Read More

    Use of Intra-Aortic Counterpulsation in Cardiogenic Shock Post Liver Transplantation.
    Clin Transplant 2017 May 10. Epub 2017 May 10.
    Department of Surgery, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH, 44106, USA.
    Left ventricular dysfunction resulting in cardiogenic shock occurs infrequently following organ reperfusion in liver transplantation. The etiology of the cardiogenic shock is often multifactorial and difficult to manage due to the complex nature of the procedure and the patient's baseline physiology. Traditionally, this hemodynamic instability is managed medically using inotropic agents and vasopressor support. Read More

    Intra-aortic balloon pump in cardiogenic shock: state of the art.
    Rev Col Bras Cir 2017 Jan-Feb;44(1):102-106
    - Heart Institute, Clinics Hospital, School of Medicine, University of São Paulo, Surgical Laboratory of Cardiovascular Research, Sao Paulo, Sao Paulo State, Brazil.
    The clinical definition of cardiogenic shock is that of a low cardiac output and evidence of tissue hypoxia in the presence of adequate blood volume. Cardiogenic shock is the main cause of death related to acute myocardial infarction (AMI), with a mortality rate of 45-70% in the absence of aggressive and highly specialized technical care. The intra-aortic balloon pump (IABP) is one of the most widely used mechanical assisting devices. Read More

    Daily transient discontinuation of extracorporeal LVAD to prevent thromboembolism of mechanical aortic valve prosthesis.
    J Artif Organs 2017 May 9. Epub 2017 May 9.
    Department of Cardiovascular Surgery, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami Ku, Sagamihara, Kanagawa Prefecture, 252-0374, Japan.
    Patients with mechanical aortic valves are generally contraindicated for left ventricular assist device (LVAD) insertion because the prosthetic valve often becomes fixed in closed position. A 41-year-old woman with mechanical aortic valve prosthesis experienced sudden chest pain and developed cardiogenic shock. A paracorporeal pulsatile LVAD and a monopivot centrifugal pump as a right VAD (RVAD) were implanted. Read More

    Reversible Myocardial Injury and Intraventricular Thrombus Associated with Aluminium Phosphide Poisoning.
    Case Rep Cardiol 2017 9;2017:6287015. Epub 2017 Apr 9.
    Department of Cardiology B, Ibn Sina Hospital, Mohammed V University, Rabat, Morocco.
    Aluminium phosphide (ALP) is widely used as a fumigant pesticide. In case of ALP poisoning, it is responsible for myocardial dysfunction, related to toxic myocarditis, and hemodynamic disorders. We report a case of a 28-year-old female who had intentionally ingested ALP and was admitted with cardiogenic shock. Read More

    Clinical Characteristics and Current Interventions in Shock Patients in Chinese Emergency Departments: A Multicenter Prospective Cohort Study.
    Chin Med J (Engl) 2017 May;130(10):1146-1154
    Emergency Department, Peking Union Medical College Hospital, Beijing 100730, China.
    Background: Shock is a life-threatening condition in emergency departments (EDs) and is associated with a high mortality; however, its clinical characteristics and current interventions in China are seldom reported. This study investigated the clinical characteristics and current interventions of shock patients in Chinese EDs.

    Methods: This multicenter prospective cohort study was conducted in the EDs of 33 academic hospitals in 16 Chinese provinces. Read More

    Advanced Age as a Predictor of Survival and Weaning in Venoarterial Extracorporeal Oxygenation: A Retrospective Observational Study.
    Biomed Res Int 2017 6;2017:3505784. Epub 2017 Apr 6.
    Department of Thoracic and Cardiovascular Surgery, School of Medicine, Kangwon National University, Chuncheon-si, Gangwon-do, Republic of Korea.
    Background. In most reports on ECMO treatment, advanced age is classified as a contraindication to VA ECMO. We attempted to investigate whether advanced age would be a main risk factor deciding VA ECMO application and performing VA ECMO support. Read More

    Development of high-grade daptomycin resistance in Corynebacterium striatum while on therapy.
    Antimicrob Agents Chemother 2017 May 8. Epub 2017 May 8.
    Division of Infectious Diseases, Mayo Clinic, 200 First Street SW, Rochester MN 55905.
    We report of a 62-year-old male with ischemic cardiomyopathy complicated by cardiogenic shock who underwent placement of a left-ventricular assist device (HeartMate II LVAD) in July 2013 as destination therapy.…. Read More

    Update on the risk stratification of acute symptomatic pulmonary thromboembolism.
    Rev Clin Esp 2017 May 2. Epub 2017 May 2.
    Servicio de Medicina Interna, Hospital Universitario Germans Trias i Pujol, Badalona, Barcelona, España.
    Early mortality in patients with pulmonary thromboembolism (PTE) varies from 2% in normotensive patients to 30% in patients with cardiogenic shock. The current risk stratification for symptomatic PTE includes 4 patient groups, and the recommended therapeutic strategies are based on this stratification. Patients who have haemodynamic instability are considered at high risk. Read More

    Trends in the management and outcomes of patients admitted with acute coronary syndrome complicated by cardiogenic shock over the past decade: Real world data from the acute coronary syndrome Israeli survey (ACSIS).
    Oncotarget 2017 Apr 17. Epub 2017 Apr 17.
    Department of Cardiology, Assaf Harofeh Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Zerifin, Israel.
    Registries and other cohorts have demonstrated that early revascularization improve the survival of patients presenting with Cardiogenic Shock (CS) completing Aute coronary syndrome (ACS). Our aim was to describe the change in the clinical characteristics of these patients and their management and their outcome. The study population comprised 224 patients who were admitted with ACS complicated by cardiogenic shock who were enrolled in the prospective biannual Acute Coronary Syndrome Israeli Surveys (ACSIS) between 2000 and 2013 (1. Read More

    Impact of Collateral Circulation on Survival in ST-Segment Elevation Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Intervention With a Concomitant Chronic Total Occlusion.
    JACC Cardiovasc Interv 2017 May;10(9):906-914
    Department of Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands. Electronic address:
    Objectives: This study sought to compare long-term clinical outcome in ST-segment elevation myocardial infarction (STEMI) patients with a concomitant chronic total occlusion (CTO) with well-developed versus poorly developed collaterals toward the CTO.

    Background: In STEMI patients, presence of a CTO is associated with increased morbidity and mortality. CTOs are often (partially) perfused by collateral vessels. Read More

    Short-term mechanical circulatory support as a bridge to durable left ventricular assist device implantation in refractory cardiogenic shock: a systematic review and meta-analysis.
    Eur J Cardiothorac Surg 2017 May 3. Epub 2017 May 3.
    Department of Cardiology, Thoraxcenter, Erasmus Medical Center, Rotterdam, Netherlands.
    Summary: Short-term mechanical circulatory support (MCS) is increasingly used as a bridge to decision in patients with refractory cardiogenic shock. Subsequently, these patients might be bridged to durable MCS either as a bridge to candidacy/transplantation, or as destination therapy. The aim of this study was to review support duration and clinical outcome of short-term MCS in cardiogenic shock, and to analyse application of this technology as a bridge to long-term cardiac support (left ventricular assist device, LVAD) from 2006 till June 2016. Read More

    Angioinvasive Aspergillus-associated Stroke in an Immunocompetent Host Following Cardiac Surgery and ECMO.
    Neurologist 2017 May;22(3):92-94
    Cedars-Sinai Medical Center, Los Angeles, CA.
    Introduction: Invasive cerebral aspergillosis is an uncommon cause of stroke among immunocompetent patients and has not been reported in association with cardiac surgery or extracorporeal membrane oxygenation (ECMO). We report the case of an immunocompetent host who developed aspergillus-associated stroke following coronary artery bypass graft (CABG) and ECMO.

    Case Report: A 59-year-old woman developed cardiogenic shock after 3-vessel-CABG requiring intra-aortic balloon pump placement and subsequent veno-arterial ECMO. Read More

    Extracorporeal Membrane Oxygenation for Acute Decompensated Heart Failure.
    Crit Care Med 2017 May 3. Epub 2017 May 3.
    1Service de Réanimation, Institut de Cardiologie, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, Paris, France. 2Sorbonne Universités, UPMC Université Paris 06, INSERM, UMRS_1166-ICAN Institute of Cardiometabolism and Nutrition, Paris, France. 3Service de Chirurgie Thoracique et Cardiovasculaire, Institut de Cardiologie, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, Paris, France.
    Objective: Long-term outcomes of patients treated with venoarterial-extracorporeal membrane oxygenation for acute decompensated heart failure (i.e., cardiogenic shock complicating chronic cardiomyopathy) have not yet been reported. Read More

    Recurrence of non-cardiogenic pulmonary edema and sustained hypotension shock in cystic pheochromocytoma.
    J Zhejiang Univ Sci B 2017 May;18(5):449-452
    Department of Cardiology, Zhejiang Provincial Hospital of Traditional Chinese Medicine, Hangzhou 310006, China.
    Pheochromocytoma is a rare neuroendocrine tumor which derives from chromaffin cells of the adrenal gland or relevant to sympathetic nerves and ganglia. The clinical features of pheochromocytoma are various. Paroxysmal episodes of serious hypertension, headache, palpitation, and diaphoresis are the typical manifestations (Bravo, 2004). Read More

    Prevalence of hemolysis and metabolic acidosis in patients with circulatory failure supported with extracorporeal life support: a marker for survival?
    Eur J Heart Fail 2017 May;19 Suppl 2:110-116
    Department of Internal Medicine II, University Hospital Regensburg, Franz-Josef-Strauss-Allee 11, 93042, Regensburg, Germany.
    Aims: Elevated levels of plasma free hemoglobin (fHb) indicate red blood cell (RBC) damage. The aim of this study was to analyze the prevalence of hemolysis and metabolic acidosis in patients on extracorporeal life support (ECLS) and to investigate whether it is a marker for outcome.

    Methods And Results: This retrospective analysis included 215 adult patients with cardiac failure treated with ECLS. Read More

    Modalities and Effects of Left Ventricle Unloading on Extracorporeal Life support: a Review of the Current Literature.
    Eur J Heart Fail 2017 May;19 Suppl 2:84-91
    Department of Cardiothoracic Surgery, Maastricht University Medical Center +, Maastricht, The Netherlands.
    Introduction/aim: Veno-arterial extracorporeal membrane oxygenation (V-A ECMO) support is increasingly used in refractory cardiogenic shock and cardiac arrest, but is characterized by a rise in afterload of the left ventricle (LV) which may ultimately either further impair or delay cardiac contractility improvement. The aim of this study was to provide a comprehensive overview regarding the different LV venting techniques and results currently available in the literature.

    Methods: A systematic literature search was performed in the PubMed database: 207 articles published between 1993 and 2016 were included. Read More

    A rationale for early extracorporeal membrane oxygenation in patients with postinfarction ventricular septal rupture complicated by cardiogenic shock.
    Eur J Heart Fail 2017 May;19 Suppl 2:97-103
    2nd Department of Medicine - Department of Cardiovascular Medicine, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic.
    Aims: Ventricular septal rupture (VSR) became a rare mechanical complication of myocardial infarction in the era of percutaneous coronary interventions but is associated with extreme mortality in patients who present with cardiogenic shock (CS). Promising outcomes have been reported with the use of circulatory support allowing haemodynamic stabilization, followed by delayed repair. Therefore, we analysed our experience with an early use of Veno-Arterial Extracorporeal Membrane Oxygenation (V-A ECMO) for postinfarction VSR. Read More

    Extra corporeal membrane oxygenation in the therapy of cardiogenic shock (ECMO-CS): rationale and design of the multicenter randomized trial.
    Eur J Heart Fail 2017 May;19 Suppl 2:124-127
    2nd Department of Medicine - Department of Cardiovascular Medicine, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic.
    Aims: Extracorporeal membrane oxygenation (ECMO) in veno-arterial configuration represents an increasingly used method for circulatory support. ECMO in cardiogenic shock offers rapid improvement of circulatory status and significant increase in tissue perfusion. Current evidence on the use of ECMO in cardiogenic shock remains insufficient. Read More

    Isolated left ventricular failure is a predictor of poor outcome in patients receiving veno-arterial extracorporeal membrane oxygenation.
    Eur J Heart Fail 2017 May;19 Suppl 2:104-109
    Department of Intensive Care Medicine, Erasmus Medical Center, Rotterdam, the Netherlands.
    Aims: We investigated survival according to the nature of heart failure (isolated left, vs isolated right, vs biventricular heart failure) in patients undergoing extracorporeal membrane oxygenation (ECMO) for refractory cardiogenic shock of different causes.

    Methods And Results: This single-center study included 132 patients with acute myocardial infarction (20%), acute on chronic heart failure (14%), post cardiotomy (17%), cardiac allograft failure (8%), pulmonary embolism (16%), and acute nonischemic heart failure (25%). Ventricular function was a priori assessed by transthoracic echocardiography (isolated left (26%), isolated right (22%), or biventricular heart failure (52%)). Read More

    The ICM research agenda on extracorporeal life support.
    Intensive Care Med 2017 May 3. Epub 2017 May 3.
    Réanimation des Détresses Respiratoires et Infections Sévères, CHU Nord, UMR CNRS 7278, Aix-Marseille Université, Marseille, France.
    Purpose: This study aimed to concisely describe the current standards of care, major recent advances, common beliefs that have been contradicted by recent trials, areas of uncertainty, and clinical studies that need to be performed over the next decade and their expected outcomes with regard to extracorporeal membrane oxygenation (ECMO).

    Methods: Narrative review based on a systematic analysis of the medical literature, national and international guidelines, and expert opinion.

    Results: The use of venovenous ECMO (VV-ECMO) is increasing in the most severe forms of acute lung injury. Read More

    Left Ventricular Mechanical Support with the Impella during Extracorporeal Membrane Oxygenation.
    J Tehran Heart Cent 2017 Jan;12(1):11-14
    Hackensack University Medical Center, Hackesack, NJ, USA.
    Background: Venoarterial extracorporeal membrane oxygenation (ECMO) provides systemic arterial support without directly unloading the left heart, which causes an elevated left ventricular (LV) pressure. The aim of the present study was to investigate the adjunctive application of the Impella device for LV unloading in patients during ECMO. Methods: This retrospective cohort study included patients who received Impella support in addition to venoarterial ECMO between April 2012 and December 2015. Read More

    Circulating bile acids predict outcome in critically ill patients.
    Ann Intensive Care 2017 Dec 2;7(1):48. Epub 2017 May 2.
    Division of Gastroenterology and Hepatology, Department Internal Medicine 3, Medical University of Vienna, Vienna, Austria.
    Background: Jaundice and cholestatic hepatic dysfunction are frequent findings in critically ill patients associated with increased mortality. Cholestasis in critically ill patients is closely associated with stimulation of pro-inflammatory cytokines resulting in impaired bile secretion and subsequent accumulation of bile acids. Aim of this study was to evaluate the clinical role of circulating bile acids in critically ill patients. Read More

    [Cardiac support and replacement systems].
    Med Klin Intensivmed Notfmed 2017 May 2. Epub 2017 May 2.
    Universitäres Herzzentrum Lübeck Medizinische Klinik II (Kardiologie, Angiologie, Intensivmedizin), Universitätsklinikum Schleswig-Holstein, Campus Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Deutschland.
    In recent years, the widespread use of partial mechanical cardiac support and even temporary complete replacement of cardiac function has been established in many intensive care units in the treatment of refractory cardiogenic shock. There is a difference between partial left-ventricular assist devices (LVAD) and the possibility of complete heart (and lung) replacement by extra corporeal life support (ECLS). Despite the use of mechanical support devices, the mortality of cardiogenic shock remains high. Read More

    Clinical phenotypes and outcome of patients hospitalized for acute heart failure: the ESC Heart Failure Long-Term Registry.
    Eur J Heart Fail 2017 Apr 30. Epub 2017 Apr 30.
    ANMCO Research Center, Florence, Italy.
    Aims: To identify differences in clinical epidemiology, in-hospital management and 1-year outcomes among patients hospitalized for acute heart failure (AHF) and enrolled in the European Society of Cardiology Heart Failure Long-Term (ESC-HF-LT) Registry, stratified by clinical profile at admission.

    Methods And Results: The ESC-HF-LT Registry is a prospective, observational study collecting hospitalization and 1-year follow-up data from 6629 AHF patients. Among AHF patients enrolled in the registry, 13. Read More

    Comparison of 30-Day and Long-Term Outcomes and Hospital Complications Among Patients Aged <75 Versus ≥75 Years With ST-Elevation Myocardial Infarction Undergoing Percutaneous Coronary Intervention.
    Am J Cardiol 2017 Apr 8. Epub 2017 Apr 8.
    Division of Cardiovascular Medicine, NYU Langone Medical Center, New York University School of Medicine, New York, New York. Electronic address:
    Our aim was to evaluate the mortality rate and occurrence of complications in patients aged <75 versus ≥75 years with ST-elevation myocardial infarction (STEMI). We studied 1,657 consecutive patients with STEMI hospitalized in the cardiac intensive care unit during 2008 to 2014. All patients underwent primary percutaneous intervention, of which 292 (18%) were aged ≥75 years. Read More

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