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Am J Cardiol 2022 May 18. Epub 2022 May 18.

Harrington Heart and Vascular Institute, Case Western Reserve University, Cleveland, Ohio. Electronic address:

The optimal timing of postinfarction ventricular septal defect (PI-VSD) repair is subject to debate. Patients with ventricular septal defect (VSD) and ST-elevation myocardial infarction (STEMI) were queried using appropriate International Classification of Diseases, Ninth and Tenth Revision Clinical Modification codes from the National Inpatient Sample (2003 to 2018). VSD repair was identified using appropriate International Classification of Diseases, Ninth and Tenth Revision Procedure Coding System codes. Read More

Eur Heart J Acute Cardiovasc Care 2022 May 20. Epub 2022 May 20.

Hospital Rudolfstiftung, Vienna, Austria.

Aims: To determine the current state of the use of reperfusion and adjunctive therapies and in-hospital outcomes in European Society of Cardiology (ESC) member and affiliated countries for patients with ST-segment elevation myocardial infarction (STEMI) complicated by cardiogenic shock (CS).

Methods And Results: ESC EurObservational Research Programme prospective international cohort study of admissions with STEMI within 24 h of symptom onset (196 centres; 26 ESC member and 3 affiliated countries). Of 11 462 patients enrolled, 448 (3. Read More

J Surg Case Rep 2022 May 17;2022(5):rjac131. Epub 2022 May 17.

Department of Surgery, Trauma and Vascular Surgery, Hamad Medical Corporation, Qatar.

Thyroid storm (TS) is a rare but life-threatening complication of hyperthyroidism in which multiorgan failure (MOF) is the most common cause of death. Early diagnosis and treatment of TS are challenging. We presented two cases with refractory TS complicated with arrhythmia, cardiac arrest, cardiogenic shock and MOF and were not responding to medical treatment, therapeutic plasma exchange or continuous renal replacement therapy. Read More

Cureus 2022 Apr 16;14(4):e24188. Epub 2022 Apr 16.

Division of Infectious Diseases and Geographic Medicine, University of Texas Southwestern Medical Center, Dallas, USA.

We report the fiftieth case in the literature of species peritoneal dialysis (PD)-related peritonitis and the third reported case of bacteremia associated with PD-related peritonitis. Our review provides the most up-to-date collection of all fifty reported cases of PD-related peritonitis caused by  species. A 77-year-old Caucasian male with a past medical history significant for new-onset left-ventricular systolic heart failure, severe mitral valve regurgitation, and end-stage renal disease on PD for six months presented to the emergency department with a one-week cloudy peritoneal effluent and intermittent abdominal pain. Read More

J Cardiol 2022 May 16. Epub 2022 May 16.

Department of Cardiology and Nephrology, Mie University Graduate School of Medicine, Tsu, Japan.

Background: Although serum uric acid (UA) is considered as a risk factor for cardiovascular disease, few data exist regarding the relationship between hyperuricemia, coronary blood flow, and subsequent outcome in patients with acute myocardial infarction (AMI). The purpose of our study is to assess whether hyperuricemia is associated with suboptimal coronary flow and increased risk of mortality in patients with AMI after percutaneous coronary intervention (PCI).

Methods: Using the Rural AMI registry data, 989 consecutive patients with AMI who underwent emergent PCI and had UA measurement at admission were analyzed. Read More

JACC Cardiovasc Interv 2022 May;15(10):1074-1084

King's College Hospital NHS Foundation Trust, London, United Kingdom; School of Cardiovascular Medicine & Sciences, British Heart Foundation Centre of Excellence, King's College London, London, United Kingdom.

Objectives: The purpose of this study was to evaluate the impact of performing immediate coronary angiography (CAG) after out-of-hospital cardiac arrest (OHCA) with stratification of predicted neurologic injury and cardiogenic shock on arrival to a center.

Background: The role of immediate CAG for patients with OHCA is unclear, which may in part be explained by the majority of patients dying of hypoxic brain injury.

Methods: Between May 2012 and July 2020, patients from 5 European centers were included in the EUCAR (European Cardiac Arrest Registry). Read More

Cardiovasc Pathol 2022 May 16:107435. Epub 2022 May 16.

Department of Cardiology, Saiseikai Senri Hospital 1-1-6 Tsukumodai, Suita, Osaka 565-0862, Japan.

Myocardial injury has been reported as a complication of COVID-19. Although several mechanisms have been proposed as its cause, they are mostly based on autopsy studies, We report a 49-year-old male with COVID-19-associated myocardial injury presented like fulminant myocarditis. We performed endomyocadial biopsy on day 2 and we confirmed the presence of microthrombosis histologically. Read More

Semin Thorac Cardiovasc Surg 2022 May 16. Epub 2022 May 16.

Department of Cardiac Surgery, Michigan Medicine, Ann Arbor, Michigan. Electronic address:

With increasing specialization within the field of cardiac surgery and a positive relationship between case volume and surgical outcomes in many areas, the concept of dedicated aortic surgeons performing acute type A aortic dissection (ATAAD) repair was investigated. From 1996 to 2014, 436 patients underwent open surgical repair of an ATAAD and were subsequently divided based on surgeon subspecialization, aortic-surgeon (AS, n=401) vs. non-aortic-surgeon (NAS, n=35). Read More

Curr Neurol Neurosci Rep 2022 May 19. Epub 2022 May 19.

Department of Neurology and Rehabilitation, University of Illinois at Chicago College of Medicine, 912 S. Wood Street, M/C 796, Chicago, IL, 172C60612, USA.

Purpose Of Review: The present review discusses the neurological complications associated with myocarditis of different etiologies.

Recent Findings: Myocarditis can be idiopathic or caused by different conditions, including toxins, infections, or inflammatory diseases. Clinical findings are variable and range from mild self-limited shortness of breath or chest pain to hemodynamic instability which may result in cardiogenic shock and death. Read More

Expert Rev Cardiovasc Ther 2022 May 19. Epub 2022 May 19.

Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua Medical School, Padua, Italy.

Introduction: Acute myocardial infarction (AMI) complicated by cardiogenic shock (CS) is a life-threatening condition frequently encounter in patients with multivessel coronary artery disease (MVD).

Areas Covered: Despite prompt revascularization, in particular percutaneous coronary intervention (PCI), and therapeutic and technological advances, the mortality rate for CS related to AMI remain unacceptably high. Differently form hemodynamically stable setting, a culprit lesion-only (CLO) revascularization strategy is currently suggested in AMI-CS patients, based on the results of a recent randomized evidence burdened by several limitations and conflicting results from non-randomized studies. Read More

Eur J Cardiothorac Surg 2022 May 19. Epub 2022 May 19.

Division of Cardiac Surgery, Heart Centre Siegburg-Wuppertal, University Witten-Herdecke, Germany.

Background: Extensive infective endocarditis stays a serious life-threatening disease with high mortality and morbidity. The aim of this study is to analyze our experience with our modified surgical technique for extensive infective endocarditis during the last 4 years.

Methods: Between March 2017 and February 2021, all patients with extensive infective endocarditis required our modified technique consisting of a radical surgical resection of all infected cardiac tissues, the replacement of infected valves, and a reconstruction of the intervalvular fibrous body, the aortic root and the left ventricular outflow tract with modified elephant trunk were included in this study. Read More

Glob Heart 2022 29;17(1):23. Epub 2022 Mar 29.

Cardiovascular department, Tanta University, EG.

Background: Stress hyperglycemia is a common finding during acute myocardial infarction and associated with poor prognosis. To reduce the occurrence of no-reflow, prognostic factors must be identified before primary percutaneous coronary intervention (PPCI). Our objective was to investigate the impact of stress hyperglycemia in non-diabetic and diabetic patients on no-reflow phenomenon after PPCI. Read More

Clin Med (Lond) 2022 May;22(3):266-270

Guy's and St Thomas' NHS Foundation Trust, London, UK.

Infection with SARS-CoV-2 may trigger a delayed hyper-inflammatory illness in children called paediatric multisystem inflammatory syndrome temporally associated with COVID-19 (PIMS-TS). A similar syndrome is increasingly recognised in adults termed multisystem inflammatory syndrome in adults (MIS-A) and may present acutely to medical or surgical specialties with severe symptoms, such as acute abdominal pain or cardiogenic shock. No national guidelines exist in the UK for the management of MIS-A and there is limited evidence to guide treatment plans. Read More

Shock 2022 May;57(5):617-629

Section of Interventional Cardiology, Division of Cardiovascular Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia.

Abstract: Despite advances in early revascularization, percutaneous hemodynamic support platforms, and systems of care, cardiogenic shock (CS) remains associated with a mortality rate higher than 50%. Several risk stratification models have been derived since the 1990 s to identify patients at high risk of adverse outcomes. Still, limited information is available on the differences between scoring systems and their relative applicability to both acute myocardial infarction and advanced decompensated heart failure CS. Read More

Acta Chir Belg 2022 May 18:1-5. Epub 2022 May 18.

Department of Abdominal Surgery, Grand Hôpital de Charleroi, Gilly, Belgium.

Background: Pheochromocytoma is a rare catecholamine-secreting tumor of neuroendocrine origin. It has a prevalence of <1% in adults with hypertension. In some cases, hypertension is associated with the classical triad of headache, sweating, and tachycardia. Read More

Kidney360 2022 Mar 14;3(3):569-579. Epub 2022 Jan 14.

Selzman Institute for Kidney Health, Section of Nephrology, Department of Medicine, Baylor College of Medicine, Houston, Texas.

Durable and temporary mechanical circulatory support (MCS) use is growing for a range of cardiovascular indications. Kidney dysfunction is common in people evaluated for or receiving durable or temporary MCS and portends worse outcomes. This kidney dysfunction can be due to preexisting kidney chronic kidney disease (CKD), acute kidney injury (AKI) related to acute cardiovascular disease necessitating MCS, AKI due to cardiac procedures, and acute and chronic MCS effects and complications. Read More

J Cardiol Cases 2022 May 3;25(5):312-315. Epub 2022 Jan 3.

Department of Cardiology, Tokyo Women's Medical University, 8-1, Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan.

Anomalous left coronary artery arising from the noncoronary cusp (LCANCC) is a rare congenital disorder. We herein describe a 17-year-old female patient with sudden cardiac arrest followed by refractory cardiogenic shock. LCANCC-induced acute myocardial infarction with left main coronary artery involvement was subsequently diagnosed, and the patient required a durable left ventricular assist device. Read More

Circ Cardiovasc Interv 2022 May 17;15(5):e011336. Epub 2022 May 17.

Division of Cardiology, Peter Munk Cardiac Centre, Toronto General Hospital, University Health Network, Canada (M.A., M.K., C.K., V.D.).

Background: It is unclear whether more effective forms of thrombus removal than current aspiration catheters would lead to improved outcomes. We sought to evaluate the prognostic role of residual thrombus burden (rTB), after manual thrombectomy, in patients undergoing primary percutaneous coronary intervention with routine manual thrombectomy in the TOTAL trial (Thrombectomy Versus PCI Alone).

Methods: This is a single-arm analysis of patients from the TOTAL trial who underwent routine manual aspiration thrombectomy. Read More

Circ Cardiovasc Interv 2022 May 17;15(5):e011534. Epub 2022 May 17.

Duke Clinical Research Institute, Duke University Medical Center, Durham, NC (M.Z., G.M.G., P.Z., D.M.W., S.V.R., T.Y.W.).

Background: Mechanical circulatory support (MCS) devices can be used in high-risk percutaneous coronary intervention (PCI). Our objective was to describe trends and outcomes of prophylactic MCS use in elective PCI for patients with stable coronary artery disease in the American College of Cardiology National Cardiovascular Data Registry's CathPCI registry.

Methods: Among 2 108 715 consecutive patients with stable coronary artery disease undergoing elective PCI in the CathPCI registry between 2009 and 2018, we examined patterns of prophylactic use of MCS. Read More

JAMA Netw Open 2022 May 2;5(5):e2211967. Epub 2022 May 2.

Children's Health of Orange County, Orange, California.

Importance: Identifying the associations between severe COVID-19 and individual cardiovascular conditions in pediatric patients may inform treatment.

Objective: To assess the association between previous or preexisting cardiovascular conditions and severity of COVID-19 in pediatric patients.

Design, Setting, And Participants: This retrospective cohort study used data from a large, multicenter, electronic health records database in the US. Read More

JAMA 2022 05;327(19):1928

Department of Emergency Medicine and Critical Care, Center Hospital of the National Center for Global Health and Medicine, Tokyo, Japan.

JAMA 2022 05;327(19):1927-1928

Division of Cardiothoracic Intensive Care, ASST Spedali Civili, Brescia, Italy.

JAMA 2022 05;327(19):1928-1929

Université de Lorraine, Centre d'Investigations Cliniques Plurithématique CHRU de Nancy, Nancy, France.

Artif Organs 2022 May 17. Epub 2022 May 17.

Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, China.

Objective: Cardiogenic shock (CS) often occurs in patients suffering from rapidly progressing end-stage heart failure or acute myocardial infarction. Mechanical circulatory support may be used for patients who do not respond to medication or revascularization to stabilize hemodynamics. Extracorporeal ventricular assist device (Extra-VAD) has been reported successful for patients with cardiogenic shock. Read More

Cardiol J 2022 May 17. Epub 2022 May 17.

Department of Cardiology, Hospital Universitario Ramón y Cajal, IRYCIS, CIBERCV, Madrid, Spain.

Background: Ventricular septal rupture (VSR) following acute myocardial infarction (AMI) is a dangerous condition. Surgical VSR closure is the definitive therapy, but there is controversy regarding the surgical timing and the bridging therapy between diagnosis and intervention. The objective of this study is to analyze the ideal time of surgical repair and to establish the contribution of mechanical circulatory support (MCS) devices on the prognosis. Read More

Int J Artif Organs 2022 May 16:3913988221100278. Epub 2022 May 16.

Queen Elizabeth Hospital Birmingham, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.

Background: Early assessment of response to Impella in cardiogenic shock may guide escalation of mechanical circulatory support. Therapeutic goal and response to Impella have not previously been defined. This study tested the hypothesis that targeting 3-h post- Impella cardiac power output index (CPOi)-"hemodynamic response"-in cardiogenic shock is associated with 12-h lactate clearance. Read More

Int J Cardiol 2022 May 13. Epub 2022 May 13.

Department of Cardiology, GB, Pant Institute of Postgraduate Medical Education and Research, New Delhi, India. Electronic address:

Background: Risk prediction following ST-Elevation Myocardial Infarction (STEMI) in resource limited countries is critical to identify patients at an increased risk of mortality who might benefit from intensive management.

Methods: North India ST-Elevation Myocardial Infarction (NORIN-STEMI) is an ongoing registry that has prospectively enrolled 3,635 STEMI patients. Of these, 3191 patients with first STEMI were included. Read More

Can J Cardiol 2022 May 13. Epub 2022 May 13.

Unit of Cardiac Intensive Care Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.

This case highlights the potent afterload-reducing effect of intra-aortic balloon pump (IABP) in acute heart failure with reduced ejection fraction (AHFrEF). The AHFrEF is characterized by prominent afterload sensitivity and IABP removal may precipitate pulmonary edema and cardiogenic shock even after adequate decongestion; angiotensin receptor/neprilysin inhibitor initiation during IABP support may bridge towards IABP weaning in such afterload-sensitive patients. Read More

Curr Probl Cardiol 2022 May 13:101251. Epub 2022 May 13.

New York Medical College at Westchester Medical Center, New York, NY, USA. Electronic address:

Introduction: There have been no studies focusing on how pulmonary hypertension (PH) affects inpatient outcomes in patients with hypertrophic cardiomyopathy (HCM) hospitalized for acute decompensated heart failure or cardiogenic shock. This study explores inpatient outcomes of patients with HCM, and concomitant PH compared to patients with HCM.

Methods: Based on the National Inpatient Sample (NIS) 2016-2018, patients admitted with a primary diagnosis of acute decompensated heart failure or cardiogenic shock were selected. Read More