4,844 results match your criteria Shock[Journal]


Complement Deposition on the Surface of RBC After Trauma Serves A Biomarker of Moderate Trauma Severity: A Prospective Study.

Shock 2019 Apr 12. Epub 2019 Apr 12.

Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

Background: Activation of the complement system and complement deposition on red blood cells (RBCs) contribute to organ damage in trauma. We conducted a prospective study in subjects with traumatic injuries to determine the pattern of complement deposition on RBC and whether they are associated with clinical outcomes.

Method: A total of 124 trauma patients and 42 healthy controls were enrolled in this prospective study. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001348DOI Listing

Trauma-Induced Long-Term Alterations of Human T Cells and Monocytes-Results of an Explorative, Cross-Sectional Study.

Shock 2019 Apr 14. Epub 2019 Apr 14.

Department of Anesthesiology, Operative Intensive Care Medicine and Pain Therapy, University Hospital of Giessen and Marburg, Giessen, Germany.

Background: Major trauma leads to complex immune reactions, known to result in a transient immunodeficiency. The long-term consequences of severe trauma on immune function and regulation as well as its clinical impact remain unclear.

Methods: Six months (ranging from -12 to +5 days) after a major trauma event, 12 former trauma patients (ISS ≥ 16) and 12 healthy volunteers were enrolled. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001358DOI Listing

Cholecystokinin Modulates the Mucosal Inflammatory Response and Prevents the Lipopolysaccharide-Induced Intestinal Epithelial Barrier Dysfunction.

Shock 2019 Apr 14. Epub 2019 Apr 14.

Department of Physiology, Ribeirão Preto Medical School. University of São Paulo. Ribeirão Preto, São Paulo, Brazil.

The intestinal mucosa plays a critical role in the organism, acting as an interface between the lamina propria and the harmful antigens in the lumen. Sepsis is associated with primary injury to the intestinal mucosa, which in turn induces bacterial translocation and hyperpermeability. Cholecystokinin (CCK) is a peptide synthesized by several cell types, whose immunomodulatory activity has been reported in experimental models of inflammation. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001355DOI Listing

The Prognostic Value of Prehospital Blood Lactate Levels to Predict Early Mortality in Acute Cardiovascular Disease.

Shock 2019 Apr 14. Epub 2019 Apr 14.

Instituto de Ciencias del Corazón (ICICOR). Hospital Clínico Universitario. Valladolid (Spain).

Introduction: The knowledge of the prognostic value of prehospital lactate (PLA) is limited. Our objective was to evaluate the predictive capacity of PLA to predict early mortality (within 48 hours) from the index event in acute cardiovascular disease (ACVD).

Methods: Prospective, longitudinal, multicenter, observational study in patients attended by advanced life support units, transferred to the emergency department of their reference hospital and diagnosed with ACVD. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001356DOI Listing

LPS-induced Hypotension in Pregnancy: The Effect of Progesterone Supplementation.

Shock 2019 Apr 14. Epub 2019 Apr 14.

Imperial College Parturition Research Group, Chelsea and Westminster Hospital, 369 Fulham Road, London, SW10 9NH, UK.

Our previous work has shown that pregnancy exacerbates the hypotensive response to both infection and LPS. The high levels of progesterone (P4) associated with pregnancy have been suggested to be responsible for the pregnancy-induced changes in the cardiovascular response to infection. Here, we test the hypothesis that P4 supplementation exacerbates the hypotensive response of the maternal cardiovascular to LPS. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001343DOI Listing
April 2019
1 Read

Selenium and Selenoprotein P Deficiency Correlates with Complications and Adverse Outcome After Major Trauma.

Shock 2019 Apr 12. Epub 2019 Apr 12.

Department of Trauma Surgery, University Hospital Munich, Ludwig-Maximilians-University, Munich, Germany.

Background: A declining selenium (Se) status constitutes a characteristic of critical illness and may affect disease course and survival. The dynamics of trauma-induced changes in biomarkers of Se status are poorly characterized, and an association with multiple organ failure (MOF) and mortality can be hypothesized. It was the aim of this study to investigate Se and selenoprotein P (SELENOP) concentrations in major trauma patients during the early posttraumatic period. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001344DOI Listing

Tudca Ameliorates Liver Injury Via Activation of SIRT1-FXR Signaling in a Rat Hemorrhagic Shock Model.

Shock 2019 Apr 14. Epub 2019 Apr 14.

Department of Emergency, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Objective: To investigate the changes of bile acids in the liver during hemorrhagic shock (HS) and their potential to attenuate liver injury via activation of SIRT1 (sirtuin 1)-FXR (farnesoid X receptor) signaling.

Methods: A Sprague-Dawley (SD) rat HS model was established, while HepG2 cells were hypoxically cultured to simulate HS in vitro. Liver bile acids (BA) were profiled with ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). Read More

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http://dx.doi.org/10.1097/SHK.0000000000001351DOI Listing

The Effects of Pharmacological Hypothermia Induced by Neurotensin Receptor Agonist ABS 201 on Outcomes of CPR.

Shock 2019 May;51(5):667-673

Weil Institute of Emergency and Critical Care Research, Virginia Commonwealth University, Richmond, Virginia.

Neurotensin is an endogenous tridecapeptide that binds to neurotensin receptors in the brain, which induce hypothermia. The aim of this study was to investigate whether the receptor agonist ABS 201 could induce therapeutic hypothermia and improve postresuscitation outcomes in a ventricular fibrillation cardiac arrest (VFCA) rat model. VF was electrically induced in 12 rats. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001178DOI Listing
May 2019
1 Read

What's New in Shock, May 2019?

Shock 2019 May;51(5):535-537

Department of General Surgery, University of Michigan, Ann Arbor, Michigan.

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http://dx.doi.org/10.1097/SHK.0000000000001322DOI Listing

Serum Lactate and A Relative Change in Lactate as Predictors of Mortality in Patients with Cardiogenic Shock - Results from The Cardshock Study.

Shock 2019 Apr 5. Epub 2019 Apr 5.

University Hospital Copenhagen, Department of Cardiology, Rigshospitalet, Denmark.

Introduction: Cardiogenic shock complicating acute myocardial infarction has a very high mortality. Our present study focuses on serial measurement of lactate during admission due to cardiogenic shock and the prognostic effect of lactate and a relative change in lactate in patients after admission and the institution of intensive care treatment.

Methods And Results: This is a secondary analysis of the CardShock study. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001353DOI Listing
April 2019
1 Read

Acute Inflammation in Traumatic Brain Injury and Polytrauma Patients Using Network Analysis.

Shock 2019 Mar 28. Epub 2019 Mar 28.

Department of Surgery, Center for Translational Injury Research, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, Texas.

Introduction: Traumatic brain injury (TBI) is associated with secondary injury to the central nervous system (CNS) via inflammatory mechanisms. The combination of polytrauma and TBI further exacerbates the inflammatory response to injury; however, combined injury phenomena have not been thoroughly studied. In this study, we examined the inflammatory differences between patients with TBI versus patients with polytrauma, but no TBI (polytrauma). Read More

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http://dx.doi.org/10.1097/SHK.0000000000001349DOI Listing
March 2019
3 Reads

A Reply to "Carriage Before the Horse", a Letter to the Editor in Reference to "TEG Lysis Shutdown Represents Coagulopathy In Bleeding Trauma Patients: Analysis of the PROPPR Cohort" (2019; 51 (3): 273: 283).

Shock 2019 Mar 14. Epub 2019 Mar 14.

Department of Surgery, The University of Texas Health Science Center at Houston, Houston, TX Department of Surgery, The University of Texas Health Science Center at Houston, Houston, TX Department of Emergency Medicine, The University of Washington, Seattle, WA.

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http://dx.doi.org/10.1097/SHK.0000000000001346DOI Listing
March 2019
1 Read

Selenoprotein P in Myocardial Infarction with Cardiogenic Shock.

Shock 2019 Mar 14. Epub 2019 Mar 14.

Heart Center Leipzig at University of Leipzig, Department of Internal Medicine/Cardiology, Leipzig, Germany.

Background: Reperfusion strategies in acute myocardial infarction (AMI) may result in ischemia reperfusion injury characterized by increased oxidative stress, inflammation and ultimately death of myocardial tissue which may be of particular importance in infarct-related cardiogenic shock (CS). Many anti-oxidative and immune regulatory processes depend on selenium which in large proportions is bound to circulating selenoprotein P (SelP). Individual SelP patterns may therefore be associated with inflammatory response and possibly mortality in patients with CS post AMI. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001342DOI Listing
March 2019
2 Reads

Delta Neutrophil Index for the Prediction of the Development of Sepsis-Induced Acute Kidney Injury in the Emergency Department.

Shock 2019 Mar 14. Epub 2019 Mar 14.

Department of Emergency Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.

Background And Purpose: The early prediction of acute kidney injury (AKI) in sepsis and provision of timely treatment may improve outcomes. We investigated the efficacy of the delta neutrophil index (DNI)-which reflects the fraction of immature granulocytes-in predicting sepsis-induced AKI and 30-day mortality in cases of severe sepsis or septic shock.

Methods: This retrospective, observational cohort study was performed with patients prospectively integrated in a critical pathway of early-goal-directed therapy /SEPSIS. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001299DOI Listing
March 2019
3 Reads

Effects of End-Tidal Carbon Dioxide-Guided Fluid Resuscitation on Outcomes in a Cecal Ligation and Puncture Induced Rat Model of Sepsis.

Shock 2019 Apr;51(4):519-525

Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.

Cecal ligation and puncture (CLP) was used to cause severe sepsis in male Sprague-Dawley rats. There are four groups in this study: sham (n = 5), CLP (n = 10), end-tidal carbon dioxide (ETCO2) (n = 10), and mean arterial pressure (MAP) (n = 10). In ETCO2 group, fluid resuscitation (FR) began when ETCO2 at most 25 mmHg. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001179DOI Listing
April 2019
2 Reads

What'S New in Shock, April 2019?

Shock 2019 Apr;51(4):407-409

Departments of Surgery and Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida.

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http://dx.doi.org/10.1097/SHK.0000000000001305DOI Listing
April 2019
1 Read

TEG Lysis Shutdown Represents Coagulopathy in Bleeding Trauma Patients: Analysis of the PROPPR Cohort.

Shock 2019 Mar 5. Epub 2019 Mar 5.

University of Colorado, Aurora, CO United States.

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http://dx.doi.org/10.1097/SHK.0000000000001341DOI Listing

Administration of Candida Albicans to Dextran Sulfate Solution Treated Mice Causes Intestinal Dysbiosis, Emergence and Dissemination of Intestinal Pseudomonas Aeruginosa and Lethal Sepsis.

Shock 2019 Feb 28. Epub 2019 Feb 28.

Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

The influence of gut fungi in chronic colitis was investigated by repeated oral administration of Candida albicans in a 3% dextran sulfate solution (DSS) induced-colitis mouse model. Candida administration in the DSS (DSS+Candida) model enhanced the mortality rate and induced bacteremia (without candidemia) resulting from a gut perm-selectivity defect despite similar diarrheal severity in mice treated with DSS alone. The dominant fecal bacteria in DSS+Candida and DSS alone mice were Pseudomonas spp. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001339DOI Listing
February 2019
1 Read
3.045 Impact Factor

Inhibition of Aerobic Glycolysis Promotes Neutrophil to Influx to The Infectious Site via CXCR2 In Sepsis.

Shock 2019 Feb 27. Epub 2019 Feb 27.

Key Laboratory Of Sepsis Translational Medicine Of Hunan, Department of Pathophysiology, Xiangya School of Medicine, Central South University, Changsha, Hunan, 410078, China.

Recent evidences suggest that metabolic reprogramming plays an important role in the regulation of innate inflammatory response, however, the specific mechanism is unclear. In this study, we found that glycolytic inhibitor 2-deoxyglucose (2-DG) significantly improved the survival rate in cecal ligation and puncture (CLP)-induced septic mice. 2-DG-treated mice developed increased neutrophil migration to the infectious site and more efficient bacterial clearance than untreated mice. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001334DOI Listing
February 2019
7 Reads

Fatty Acid-Saturated Albumin Reduces High Mortality and Fluid Requirements In A Rat Model of Hemorrhagic Shock Plus Tourniquet and Hypotensive Resuscitation.

Shock 2019 Feb 27. Epub 2019 Feb 27.

US Army Institute of Surgical Research, JBSA Fort Sam Houston, San Antonio, Texas.

Military pre-hospital care for hemorrhage is often characterized by use of tourniquets (TQ) and permissive hypotensive resuscitation (PHR) with crystalloids or colloids, but these treatments have not been previously combined in an animal model. Although albumin resuscitation solutions have been tested, the potential effects of non-esterified fatty acids (NEFAs) bound to albumin have not been evaluated in vivo, and few studies have investigated concentrated albumin solutions to reduce fluid requirements. We created a militarily relevant rat model of trauma and hemorrhagic shock (T/HS) (27 ml/kg hemorrhage) with TQ and PHR. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001338DOI Listing
February 2019
1 Read
3.045 Impact Factor

Heparin-Binding Protein As A Prognostic Biomarker of Sepsis and Disease Severity at The Emergency Department.

Shock 2019 Feb 19. Epub 2019 Feb 19.

Division of Infection Medicine, Department of Clinical Sciences, Lund, Lund University, Sweden.

Objective: Rapid and early detection of patients at risk to develop sepsis remains demanding. Heparin-binding protein (HBP) has previously demonstrated good prognostic properties in detecting organ dysfunction among patients with suspected infections. This study aimed to evaluate the plasma-levels of HBP as a prognostic biomarker for infection-induced organ dysfunction among patients seeking medical attention at the emergency department. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001332DOI Listing
February 2019

Predictive Factors of Duration of Continuous Renal Replacement Therapy in Acute Kidney Injury Survivors.

Shock 2019 Feb 19. Epub 2019 Feb 19.

Division of Nephrology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.

The factors influencing continuous renal replacement therapy (CRRT) duration for critically ill patients with acute kidney injury (AKI) are unclear. Therefore, we investigated the clinical factors that could influence the duration of CRRT for AKI survivors. In this retrospective observational study, the medical records of all hospital survivors who required CRRT for AKI in intensive care units were analyzed. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001328DOI Listing
February 2019
1 Read

Mechanical Circulatory Support in Refractory Vasodilatory Septic Shock: A Randomized Controlled Porcine Study.

Shock 2019 Feb 15. Epub 2019 Feb 15.

First Medical Department, Faculty of Medicine in Pilsen, Charles University, Teaching Hospital Pilsen, Czech Republic.

As controversy persists regarding the benefits of mechanical circulatory support in septic shock with a predominantly vasoplegic phenotype, preclinical studies may provide a useful alternative to fill the actual knowledge gap. Here, we investigated the physiologic responses to venoarterial extracorporeal membrane oxygenation therapy (VA-ECMO) in a clinically relevant porcine peritonitis-induced model of refractory vasodilatory septic shock. In 12 anesthetized, mechanically ventilated and instrumented domestic pigs, septic shock was induced by intraperitoneally inoculating autologous feces. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001329DOI Listing
February 2019
3 Reads

Sparstolonin B: A Unique Anti-Inflammatory Agent.

Shock 2019 Feb 15. Epub 2019 Feb 15.

Department of Surgery, SUNY Upstate Medical University, Syracuse, NY, 13210, USA.

Toll-like receptors are transmembrane proteins which sense and transmit infectious and inflammatory responses to the cells expressing them. Therapeutic strategies for the blockade of excessive Toll-like receptor signaling are being actively pursued for several diseases. Recently, Sparstolonin B, isolated from Chinese herb, which suppresses selectively Toll-like receptors has been studied in various inflammatory models. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001326DOI Listing
February 2019
1 Read

Left Sided Ventricular-Arterial Coupling and Volume Responsiveness in Septic Shock Patients.

Shock 2019 Feb 15. Epub 2019 Feb 15.

Department of Critical Care Medicine, Center Hospital of Huludao, Huludao, People's Republic of China.

Background: Suboptimal ventricular arterial coupling (VAC) is one of the pivotal determinants of inefficient heart performance despite appropriate administration of fluids or vasopressors in shocks. Here, we investigate the performance of VAC in patients who are unresponsive to fluid administration in septic shock.

Methods: This is a retrospective observational study of septic shock patients (n = 35). Read More

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http://dx.doi.org/10.1097/SHK.0000000000001327DOI Listing
February 2019
1 Read

Letter to the Editor.

Shock 2019 Feb 14. Epub 2019 Feb 14.

Circadian clocks and metabolism team, Institute of Cellular and Integrative Neurosciences, CNRS (UPR3212), University of Strasbourg, Strasbourg, France.

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http://dx.doi.org/10.1097/SHK.0000000000001330DOI Listing
February 2019

Reply to the Letter to the Editor.

Shock 2019 Feb 14. Epub 2019 Feb 14.

Aix Marseille Univ, IRD, AP-HM, MEPHI, IHU-Méditerranée Infection, Marseille, France.

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http://dx.doi.org/10.1097/SHK.0000000000001331DOI Listing
February 2019

Early Peritoneal Dialysis Ameliorates Blast Lung Injury by Alleviating Pulmonary Edema and Inflammation.

Shock 2019 Feb 6. Epub 2019 Feb 6.

Department of Nephrology, Daping Hospital, Research Institute of Surgery, Army University, Chongqing, China.

Background: Blast lung injury is a high-energy trauma with high mortality for explosion victims. A treatment for blast lung injury is still lacking. The aim of this study was to observe the efficacy and mechanism of peritoneal dialysis combined with glucocorticoids (GC) in the treatment of blast lung injury in rats. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001325DOI Listing
February 2019
10 Reads

Effect of Pravastatin Pretreatment and Hypercapnia on Intestinal Microvascular Oxygenation and Blood Flow During Sepsis.

Shock 2019 Feb 1. Epub 2019 Feb 1.

Department of Anesthesiology, University Hospital Duesseldorf, Moorenstrasse 5, 40225 Duesseldorf, Germany.

Introduction: In septic patients, adequate microvascular oxygenation (μHBO2) of the intestine is vital for their outcome. Recent studies suggest that statins can ameliorate septic microcirculation in a variety of tissues. However, the effect on intestinal microvascular oxygenation and blood flow is largely unknown. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001323DOI Listing
February 2019
2 Reads

High Central Venous-To-Arterial CO2 Difference is Associated With Poor Outcomes in Patients After Cardiac Surgery: A Propensity Score Analysis.

Shock 2019 Feb 1. Epub 2019 Feb 1.

Department of Cardio-Thoracic Surgery, Drum Tower Hospital Clinical Medical College of Nanjing Medical University, Nanjing, Jiangsu, China.

Purpose: In contrast to arterial lactate, previous studies have proposed central venous-to-arterial CO2 difference (P (v-a)CO2) as a more useful guide for categorizing patients at risk of developing septic shock. It is worthwhile studying P (v-a)CO2 in determining whether it could serve as a useful predictor for poor postoperative outcomes in patients undergoing cardiac surgery. We investigated the ability of P(v-a)CO2 to predict poor outcomes of patients with postoperative cardiogenic shock. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001324DOI Listing
February 2019
16 Reads

CCR5-Positive Inflammatory Monocytes are Crucial for Control of Sepsis.

Shock 2018 Dec 7. Epub 2018 Dec 7.

Department of Pharmacology and.

Neutrophils and inflammatory monocytes control sepsis by migration to the site of infection via their chemokine receptors. CCR5 is a chemokine receptor that is not expressed on neutrophils and inflammatory monocytes under homeostatic conditions. However, it has been demonstrated that CCR5 can become expressed on these cells during different models of inflammation. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001301DOI Listing
December 2018
2 Reads

Different Bactericidal and Inflammatory Activities of Human and Mouse Blood.

Shock 2018 Dec 7. Epub 2018 Dec 7.

Department of Pediatrics, Infectious Disease Unit, Massachusetts General Hospital, Shriners Hospital for Crippled Children, and Harvard Medical School, Boston, Massachusetts.

We performed side-by-side experiments to compare the behavior of four strains of Escherichia coli and one strain of Pseudomonas aeruginosa in fresh human and mouse blood. Bacteria multiplied in mouse whole blood and plasma but were killed in human whole blood and plasma. The percentage of granulocytes associated with fluorescence-labeled heat-killed E. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001302DOI Listing
December 2018
8 Reads

Burn-Induced Microglia Activation is Associated With Motor Neuron Degeneration and Muscle Wasting in Mice.

Shock 2019 May;51(5):569-579

Department of Anesthesiology, Critical Care and Pain Medicine, Massachusetts General Hospital, Shriners Hospital for Children, Boston, Massachusetts.

Introduction: Burn injury (BI) leads to both systemic and neuro-inflammation and is associated with muscle wasting and weakness, which increase morbidity and mortality. Disuse atrophy is concomitantly present in BI patients. Most studies have focused on muscle with little attention to role of central nervous system (CNS) in the neuromuscular changes. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001300DOI Listing
May 2019
3.045 Impact Factor

Lipopolysaccharide Stress Induces Cryptic Exon Splice Variants of The Human Glucocorticoid Receptor.

Shock 2019 Jan 21. Epub 2019 Jan 21.

Shriners Hospitals for Children Northern California and Department of Surgery, University of California, Davis, Sacramento, CA 95817, USA.

Glucocorticoids are widely used in the treatment of numerous inflammatory conditions, including sepsis. Unfortunately, patient response to glucocorticoid therapy can be inconsistent. Variations in the human glucocorticoid receptor (hGR) may contribute to the differential patient response. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001318DOI Listing
January 2019

N-Acetylcysteine Ameliorates Gentamicin-Induced Nephrotoxicity by Enhancing Autophagy and Reducing Oxidative Damage in Miniature Pigs.

Shock 2019 Jan 14. Epub 2019 Jan 14.

Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Diseases, Beijing, China.

The clinical use of gentamicin over prolonged periods is limited because of dose- and time-dependent nephrotoxicity, in which intracellular oxidative stress and heightened inflammation have been implicated. Macroautophagy/autophagy is an essential and highly conserved self-digestion pathway that plays important roles in the maintenance of cellular function and viability under stress. The aim of this study was to determine changes in autophagy in response to the antioxidant N-acetylcysteine (NAC), via its effects on oxidative stress, inflammation, apoptosis, and renal function, following treatment with gentamicin in mini pigs. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001319DOI Listing
January 2019
6 Reads

Advanced Age Impairs Intestinal Antimicrobial Peptide Response and Worsens Fecal Microbiome Dysbiosis Following Burn Injury in Mice.

Shock 2019 Jan 18. Epub 2019 Jan 18.

Department of Surgery, Division of GI, Trauma and Endocrine Surgery, and Burn Research Program, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO 80045.

Maintenance of the commensal bacteria that comprise the gut microbiome is essential to both gut and systemic health. Traumatic injury, such as burn, elicits a number of changes in the gut, including a shift in the composition of the microbiome (dysbiosis), increased gut leakiness, and bacterial translocation into the lymphatic system and bloodstream. These effects are believed to contribute to devastating secondary complications following burn, including pneumonia, acute respiratory distress syndrome, multi-organ failure, and septic shock. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001321DOI Listing
January 2019
19 Reads
3.045 Impact Factor

Adenoviral βARKct Cardiac Gene Transfer Ameliorates Post-resuscitation Myocardial Injury in a Porcine Model of Cardiac Arrest.

Shock 2019 Jan 17. Epub 2019 Jan 17.

Department of Emergency, Shandong Provincial Hospital affiliated to Shandong University, Jinan, China.

Objective: To determine whether the inhibition of the G protein-coupled receptor kinase 2 by adenoviral βARKct cardiac gene transfer can ameliorate post-resuscitation myocardial injury in pigs with cardiac arrest (CA) and explore the mechanism of myocardial protection.

Methods: Male landrace domestic pigs were randomized into the sham group (Anesthetized and instrumented, but ventricular fibrillation was not induced) (n = 4), control group (ventricular fibrillation 8 min, n = 8) and βARKct group (ventricular fibrillation 8 min, n = 8). Hemodynamic parameters were monitored continuously. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001320DOI Listing
January 2019
8 Reads

Mitochondrial DNA: Innocent in Plasma, but Guilty in Urine?

Shock 2019 Feb;51(2):267

Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1097/SHK.0000000000001143DOI Listing
February 2019

Mitochondrial DNA: Innocent in Plasma, but Guilty in Urine?

Shock 2019 Feb;51(2):266

Department of Intensive Care Medicine, Radboud University Medical Center, Nijmegen, The Netherlands Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1097/SHK.0000000000001142DOI Listing
February 2019

What's New in Shock, February 2019?

Authors:
Lyle L Moldawer

Shock 2019 Feb;51(2):143-146

Sepsis and Critical Illness Research Center, Department of Surgery, University of Florida College of Medicine, Gainesville, Florida.

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http://dx.doi.org/10.1097/SHK.0000000000001292DOI Listing
February 2019
1 Read

Mitochondrial Function in the Kidney and Heart, but not the Brain, is Mainly Altered in an Experimental Model of Endotoxaemia.

Shock 2019 Jan 9. Epub 2019 Jan 9.

Latvian Institute of Organic Synthesis, Aizkraukles Str. 21, Riga, LV-1006, Latvia.

Significant impairments in mitochondrial function are associated with the development of multi-organ failure in sepsis/endotoxaemia, but the data on the dynamics of simultaneous mitochondrial impairment in multiple organs are limited. The aim of this study was to evaluate the changes in heart, brain and kidney mitochondrial function in an experimental model of lipopolysaccharide (LPS)-induced endotoxaemia.Samples were collected 4 and 24 h after single injection of LPS (10 mg/kg) in mice. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001315DOI Listing
January 2019
2 Reads

Comparison Between Continuous and Intermittent Administration of Hydrocortisone During Septic Shock: A Randomized Controlled Clinical Trial.

Shock 2019 Jan 7. Epub 2019 Jan 7.

Intensive Care Unit, University Hospital Taher Sfar Mahdia 5100, Tunisia.

Objectives: the best modality of administration of hydrocortisone during septic shock has been poorly evaluated and the guidelines remain unclear in this respect. This study aimed to compare bolus of hydrocortisone to a continuous infusion during septic shock.

Design: randomized controlled, open-label trial. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001316DOI Listing
January 2019
5 Reads
3.045 Impact Factor

The Contribution of The Omentum to the Outcome From Sepsis: An Experimental Animal Study.

Shock 2018 Dec 21. Epub 2018 Dec 21.

Division of Trauma, Critical Care, Burns and Acute Injury, Department of Surgery, School of Medicine, University of California, La Jolla, CA 92093, USA.

The omentum is a large mesenchymal fibro-fatty tissue with remarkable healing capability. It is also rich in immune cells, including macrophages, and lymphocytes, within particular structures named milky spots. Clinical observations indicate a high incidence of peritonitis after removal of the omentum suggesting that it may play a role in sepsis. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001311DOI Listing
December 2018
15 Reads

The Role of Macrophage Migration Inhibitory Factor in Remote Ischemic Conditioning Induced Hepatoprotection in A Rodent Model of Liver Transplantation.

Shock 2018 Dec 21. Epub 2018 Dec 21.

Department of Surgery and Transplantation, RWTH-Aachen University, Aachen, Germany.

Background: Macrophage migration inhibitory factor (MIF) is an important stress-regulating mediator of acute ischemia/reperfusion (I/R) injury and ischemic conditioning. The present study aimed to investigate whether MIF is involved in the effects of remote ischemic conditioning (RIC) in a rat model of orthotopic liver transplantation (OLT).

Methods: OLTs were performed in male Lewis rats (245-340 g). Read More

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http://dx.doi.org/10.1097/SHK.0000000000001307DOI Listing
December 2018
2 Reads

Protein Compositions Changes Of Circulating Microparticles In Patients With Valvular Heart Disease Subjected To Cardiac Surgery Contribute To Systemic Inflammatory Response and Disorder of Coagulation.

Shock 2018 Dec 21. Epub 2018 Dec 21.

Division of Cardiac Surgery, The First Affiliated Hospital of Sun Yat-sen University.

We recently demonstrated that circulating microparticles(MPs) from patients with valvular heart diseases (VHD) subjected to cardiac surgery impaired endothelial function and vasodilation. However, it is unknown whether or not the protein composition of these circulating MPs actually changes in response to the disease and the surgery. Circulating MPs were isolated from age-matched control subjects (n = 50) and patients (n = 50) with VHD before and 72 h after cardiac surgery. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001309DOI Listing
December 2018
2 Reads
3.045 Impact Factor

Methane-Rich Saline Protects Against Sepsis-Induced Liver Damage by Regulating The PPAR-γ/NF-κB Signaling Pathway.

Shock 2018 Dec 21. Epub 2018 Dec 21.

Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an Shaanxi 710061, People's Republic of China.

Sepsis, a life-threatening organ dysfunction due to a dysregulated response to infection, is a common complication of major surgery. Previous studies have showed that methane possesses protective properties. This study aims to investigate the protective effect of methane-rich saline (MRS) on sepsis-induced liver injury. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001310DOI Listing
December 2018
4 Reads

Histone Deacetylase Inhibitors: A Novel Strategy In Trauma And Sepsis.

Shock 2018 Dec 21. Epub 2018 Dec 21.

Department of Surgery, University of Michigan, Ann Arbor, MI, USA.

Trauma remains a leading cause of morbidity and mortality among all age groups in the United States. Hemorrhagic shock and traumatic brain injury (TBI) are major causes of preventable death in trauma. Initial treatment involves fluid resuscitation to improve the intravascular volume. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001308DOI Listing
December 2018
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Hypoxia-Inducible Factor (HIF)-1α Promotes Inflammation and Injury Following Aspiration-Induced Lung Injury in Mice.

Shock 2018 Dec 24. Epub 2018 Dec 24.

Department of Surgery, University of Michigan, Ann Arbor, Michigan.

Acid aspiration-induced lung injury is a common disease in the intensive care unit (ICU) and acute respiratory distress syndrome (ARDS). Hypoxia-inducible factor (HIF)-1α is a major transcription factor responsible for regulating the cellular response to changes in oxygen tension. A clear understanding of the function of HIF-1α in lung inflammatory response is currently lacking. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001312DOI Listing
December 2018
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Does Fenoldopam Protect Kidney in Cardiac Surgery? A Systemic Review and Meta-Analysis With Trial Sequential Analysis.

Shock 2018 Dec 26. Epub 2018 Dec 26.

Department of Critical Care Medicine, Zhongnan Hospital, Wuhan University, Wuhan 430071, Hubei Province, China.

Purpose: To assess the benefits and harms of fenoldopam for nephroprotective effects in adult patients undergoing cardiac surgery.

Methods: We conducted a systematic review with meta-analysis of randomized controlled trials (RCTs) comparing fenoldopam with placebo in cardiac surgery. Trials were systematically searched from Pubmed, EMBASE, CENTRAL and CNKI databases, up to July 30, 2018. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001313DOI Listing
December 2018

Function is Dissociated From Activation-Related Immunophenotype on Phagocytes From Patients With Sirs/Sepsis Syndrome.

Shock 2018 Dec 26. Epub 2018 Dec 26.

Unidad de Investigación Médica en Inmunoquímica. Centro Médico Nacional "Siglo XXI". Instituto Mexicano del Seguro Social. Cuauhtémoc Av. 330. Zip code 06720. Mexico City. Mexico.

Sepsis is a life-threatening condition associated with failure of at least one organ in the presence of infection. Along with SIRS, the acute systemic inflammatory syndrome without documented infection, sepsis represents a main health problem in intensive care units around the world. Hypercytokinemia and overexpression of activation-markers on leukocytes are frequently reported in SIRS/sepsis. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001314DOI Listing
December 2018
2 Reads