4,790 results match your criteria Shock[Journal]


What's New in Shock, January 2019?

Authors:
Mark G Clemens

Shock 2019 Jan;51(1):1-3

Department of Biological Sciences, University of North Carolina at Charlotte, Charlotte, North Carolina.

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January 2019

Herpes Virus Entry Mediator (HVEM) Expression Promotes Inflammation/ Organ Injury in Response to Experimental Indirect-Acute Lung Injury.

Shock 2018 May 4. Epub 2018 May 4.

Div. of Surgical Research/Department of Surgery, Lifespan-Rhode Island Hospital and Brown University, Providence, RI, USA.

Therapeutic interventions to treat acute lung injury (ALI) remain largely limited to lung-protective strategies, as a real molecular pathophysiologically driven therapeutic intervention has yet to become available. While we have previously documented the expression of HVEM on leukocytes of septic mice and critically ill patients, its functional role in shock/sepsis-induced ALI has not yet been studied. Inasmuch; a murine model of indirect ALI (iALI) was induced by hemorrhagic shock (HEM) followed by cecal ligation and puncture (CLP), septic challenge and HVEM-siRNA or PBS was administrated by intra-tracheal instillation 2 hours after hemorrhage to determine the role of HVEM in the development of experimental iALI. Read More

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Partial Deletion of Tie2 Affects Microvascular Endothelial Responses to Critical Illness in a Vascular Bed and Organ-Specific Way.

Shock 2018 Jul 30. Epub 2018 Jul 30.

Department of Pathology and Medical Biology, Medical Biology section.

Tie2 is a tyrosine kinase receptor that is mainly expressed by endothelial cells. In animal models mimicking critical illness, Tie2 levels in organs are temporarily reduced. Functional consequences of these reduced Tie2 levels on microvascular endothelial behaviour are unknown. Read More

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July 2018
5 Reads

Modulation of Peroxynitrite Reduces Norepinephrine Requirements in Ovine MRSA Septic Shock.

Shock 2018 Nov 28. Epub 2018 Nov 28.

Department of Anesthesiology, University of Texas Medical Branch, Galveston, Texas.

Vascular hypo-responsiveness to vasopressors during septic shock is a challenging problem. This study is to test the hypothesis that reactive nitrogen species (RNS), such as peroxynitrite, are major contributing factors to vascular hypo-responsiveness in septic shock. We hypothesized that adjunct therapy with peroxynitrite decomposition catalyst (PDC) would reduce norepinephrine requirements in sepsis resuscitation. Read More

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November 2018
3 Reads

Pharmacological Inhibition of Pten Restores Remote Ischemic Postconditioning Cardioprotection in Hypercholesterolemic Mice: Potential Role of PTEN/AKT/GSK3β Signals.

Shock 2018 Nov 28. Epub 2018 Nov 28.

Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, China.

Although remote ischemic postconditioning (RIPC) was shown to confer cardioprotection against myocardial ischemia/reperfusion (I/R) injury in normal animals, whether RIPC-induced cardioprotection are altered in the presence of hypercholesterolemia, a comorbidity with acute myocardial infarction (AMI) patients, has yet to be determined. Normal or 2% cholesterol chow was fed to male C57BL/6J mice for 12 weeks to induce hypercholesterolemia, then normal or hypercholesterolemic murine hearts were exposed to AMI by coronary artery ligation. RIPC was induced by four episodes of 5 min femoral artery occlusion followed by 5 min reperfusion immediately after myocardial reperfusion in mice. Read More

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November 2018
1 Read

Modulation of Endoplasmic Reticulum Stress Influences Ischemia-Reperfusion Injury After Hemorrhagic Shock.

Shock 2018 Nov 28. Epub 2018 Nov 28.

Department of Trauma Surgery, University of Heidelberg, Heidelberg, Germany.

Background: Impaired function of the endoplasmic reticulum (ER) results in ER stress, an accumulation of proteins in the ER lumen. ER stress is a major contributor to inflammatory diseases and is part of the pathomechanism of ischemia-reperfusion injury (IRI). Since severe traumatic injury is often accompanied by remote organ damage and immune cell dysfunction, we investigated the influence of ER stress modulation on the systemic inflammatory response and liver damage after hemorrhagic shock and reperfusion (HS/R). Read More

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November 2018

"Trans-Esophageal Doppler Assessment of Acute Hemodynamic Changes Due to Prone Positioning in Acute Respiratory Distress Syndrome Patients".

Shock 2018 Nov 20. Epub 2018 Nov 20.

Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGIMS), Lucknow, India.

Background: Effect of prone positioning on acute hemodynamic changes (within 10 minutes) in acute respiratory distress syndrome (ARDS) has not been studied.

Methods: In this prospective observational study, hemodynamic assessment by trans-esophageal Doppler (TED) was done with the primary aim to measure early changes in cardiac index (CI), if any, after prone positioning in moderate to severe ARDS patients. A subgroup analysis was also done based on the response to passive leg raise (PLR). Read More

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November 2018
5 Reads

What's New in Shock, March 2019?

Shock 2018 Nov 20. Epub 2018 Nov 20.

Pulmonary, Critical Care, Allergy, and Sleep Medicine, Medical University of South Carolina, Charleston, South Carolina.

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November 2018
1 Read

Hemorrhage Attenuates Neutrophil Recruitment in Response to Secondary Respiratory Infection by Pseudomonas Aeruginosa.

Shock 2018 Nov 20. Epub 2018 Nov 20.

Division of Surgical Research, Department of Surgery, Rhode Island Hospital, Providence, RI 02903.

Neutrophil recruitment into the lung airspaces plays an important role in the containment and clearance of bacteria. Hemorrhagic shock, a complication of traumatic injury, induces immune dysfunction that compromises host defense and frequently leads to secondary infection. The objective of the current study was to determine whether prior hemorrhage impacts neutrophil recruitment in response to secondary Pseudomonas aeruginosa. Read More

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November 2018
4 Reads

Dexmedetomidine Attenuates Acute Lung Injury Induced by Heatstroke and Improve Outcome.

Shock 2018 Nov 20. Epub 2018 Nov 20.

The Institute of Antibody Engineering, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515, P. R. China.

Introduction: Dexmedetomidine (DEX) has been demonstrated to inhibit inflammatory response and protect against multiorgan injury in various scenarios. The objectives of the present study was to ascertain whether DEX is able to attenuate acute lung injury (ALI) under heatstroke (HS), and to explore the underlying mechanism.

Methods: Male C57BL/6 mice were exposed to ambient temperature of 39. Read More

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November 2018
3 Reads

Comment From the Editorial Office on "Is Triple Self-Plagiarism "OK" if Only Made Transparent?"

Authors:
Mark G Clemens

Shock 2019 Jan;51(1):142

Center for Biomedical Science and Engineering, University of North Carolina at Charlotte, Charlotte, North Carolina.

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January 2019

Is Triple Self-Plagiarism "OK" If Only Made Transparent?

Authors:
Volker R Jacobs

Shock 2019 Jan;51(1):139

Department of Gynecology and Obstetrics (OB/GYN), Paracelsus Medical University (PMU), Salzburg, Austria.

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January 2019

The Response to the Letter to the Editor Titled: "Is Triple Self-plagiarism "OK" If Only Made Transparent?" by Volker R Jacobs, MD, MBA.

Shock 2019 Jan;51(1):140-141

Ludwig Boltzmann Institute for Experimental and Clinical Traumatology in the AUVA Research Center, Vienna, Austria University of California School of Medicine, San Francisco, California Institute of Clinical and Experimental Trauma-Immunology, University Hospital of Ulm, Ulm, Germany Center for Inflammation Research, VIB, University Ghent, Ghent, Belgium Boston University School of Medicine, Boston, Massachusetts The William Harvey Research Institute, Barts and London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom Division of Critical Care Medicine, Cincinnati Children's Hospital Medical Center, College of Medicine, University of Cincinnati, Cincinnati, Ohio.

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January 2019
1 Read

A Novel Perfusion System for Damage Control of Hyperkalemia in Swine.

Shock 2018 Dec;50(6):677-683

Clinical Investigation Facility, David Grant USAF Medical Center, Travis Air Force Base, California.

Introduction: The standard of care for refractory hyperkalemia is renal replacement therapy (RRT). However, traditional RRT requires specialized equipment, trained personnel, and large amounts of dialysate. It is therefore poorly suited for austere environments. Read More

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December 2018
4 Reads

What's New in Shock, December 2018?

Authors:
Mark G Clemens

Shock 2018 Dec;50(6):613-615

University of North Carolina at Charlotte, Charlotte, North Carolina.

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December 2018

Do Sepsis-3 criteria facilitate earlier recognition of sepsis and septic shock? A retrospective cohort study.

Shock 2018 May 8. Epub 2018 May 8.

Department of Anesthesiology, University Hospital of Greifswald, Germany.

Background: New Sepsis-3 criteria are supposed to "facilitate earlier recognition…of patients with sepsis". To test this, we performed novel and direct comparisons of Sepsis-1 vs. Sepsis-3 criteria with respect to time differences of sepsis onset. Read More

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May 2018
1 Read

Cardiac Effects of Hyperoxia During Resuscitation from Hemorrhagic Shock in Swine.

Shock 2018 Nov 6. Epub 2018 Nov 6.

Institut fu[Combining Diaeresis]r Ana[Combining Diaeresis]sthesiologische Pathophysiologie und Verfahrensentwicklung, Universita[Combining Diaeresis]tsklinikum Ulm, Ulm, Germany.

Hyperoxia (ventilation with FIO2 = 1.0) has vasoconstrictor properties, in particular in the coronary vascular bed, and, hence, may promote cardiac dysfunction. However, we previously showed that hyperoxia attenuated myocardial injury during resuscitation from hemorrhage in swine with coronary artery disease. Read More

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November 2018
7 Reads

MIR-190B Alleviates Cell Autophagy and Burn-Induced Skeletal Muscle Wasting via Modulating PHLPP1/AKT/FOXO3A Signaling Pathway.

Shock 2018 Nov 6. Epub 2018 Nov 6.

Burn Institute, the First Affiliated Hospital of PLA General Hospital, Beijing, 100048 China.

Introduction: Cell autophagy is an important material recycling process and is involved in regulating many vital activities under both physiological and pathological conditions. However, the mechanism of autophagy regulating burn-induced skeletal muscle wasting still needs to be elucidated.

Methods: The rat burn model with 30% total body surface area and L6 cell line were used in this study. Read More

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November 2018
3 Reads

The Effect of Nutrition on Early Stress-Induced Hyperglycemia, Serum Insulin Levels, and Exogenous Insulin Administration in Critically Ill Patients with Septic Shock: A Prospective Observational Study.

Shock 2018 Nov 6. Epub 2018 Nov 6.

Gelderse Vallei Hospital, Department of Intensive Care Medicine, Willy Brandtlaan 10, 6716 RP, Ede, the Netherlands.

Background: Stress-induced hyperglycemia is common among septic shock patients. Nutritional support influences glucose homeostasis but this effect has never been studied in septic shock. We aimed to determine the course of hyperglycemia and serum insulin levels in critically ill septic shock patients and to address the effects of caloric intake on glycemia, insulin levels, and exogenous insulin requirements. Read More

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November 2018
4 Reads

Plasma Renin Concentration is Associated with Hemodynamic Deficiency and Adverse Renal Outcome in Septic Shock.

Shock 2018 Nov 6. Epub 2018 Nov 6.

From Department of Anesthesiology and Intensive Care, C.H.U. Dijon, France.

Background: In septic shock, both systemic vasodilatation and glomerular arteriole dilatation are responsible for the drop in glomerular filtration observed in early acute kidney injury. Angiotensin II has been showed to act on both mechanisms. Our objective was to evaluate the impact of renin angiotensin system activation, on hemodynamic deficiency and renal outcome in patient with septic shock and to assess whether urinary sodium could be a reliable test for high plasma renin concentration screening. Read More

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November 2018
1 Read

Effect of Coagulation Factor Concentrates on Markers of Endothelial Cell Damage in Experimental Hemorrhagic Shock.

Shock 2018 Nov 6. Epub 2018 Nov 6.

Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, AUVA Trauma Research Center, Vienna.

Background: Plasma-based resuscitation showed protective effects on the endothelial glycocalyx compared to crystalloid resuscitation. There is paucity of data regarding the effect of coagulation factor concentrates (CFC) on the glycocalyx in hemorrhagic shock (HS). We hypothesized that colloid-based resuscitation supplemented with CFCs offers a therapeutic value to treat endothelial damage following HS. Read More

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November 2018
5 Reads

Cirrhotic Patients Admitted to the ICU with Septic Shock: Factors Predicting Short and Long-Term Outcome.

Shock 2018 Nov 1. Epub 2018 Nov 1.

Service de Réanimation Médicale, Hospices Civils de Lyon, Hôpital Edouard Herriot, Lyon, France.

Cirrhotic patients with septic shock have a poor prognosis in ICU compared to general population of critically ill patients. Little is known about long-term outcome in these patients. We performed a retrospective analysis of a prospective cohort of cirrhotic patients with septic shock. Read More

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November 2018
4 Reads

Incidence, Patient Characteristics, Mode of Drug Delivery, and Outcomes of Septic Shock Patients Treated with Vasopressors in the Arise Trial.

Shock 2018 Oct 30. Epub 2018 Oct 30.

Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.

Introduction: To describe the utilization of vasopressors (VP) in patients enrolled in the Australasian Resuscitation In Sepsis Evaluation (ARISE) trial, and to explore the association between time to VP and 90-day mortality.

Methods: The primary exposure variable was VP use after arrival in the emergency department (ED). Vasoactive agents considered as VP included: norepinephrine, epinephrine, metaraminol, or vasopressin. Read More

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October 2018
3 Reads

Acute Lung Injury in Critically Ill Patients: Actin-Scavenger Gelsolin Signals Prolonged Respiratory Failure.

Shock 2018 Oct 18. Epub 2018 Oct 18.

Department of Internal Medicine, Herlev and Gentofte University Hospital, Hellerup, Denmark.

Background: Gelsolin is an actin-scavenger controlling the tissue damage from actin in the blood. Gelsolin levels in circulation drops when tissue damage and corresponding actin release is pronounced due to catabolic conditions. The purpose of this study was to determine if low plasma gelsolin independently predicts a reduced chance of weaning from ventilator-demanding respiratory failure in critically ill patients within 28 days from admission. Read More

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October 2018
1 Read
3.045 Impact Factor

Sphingosine-1-Phosphate Reduces Hemorrhagic Shock and Resuscitation-Induced Microvascular Leakage by Protecting Endothelial Mitochondrial Integrity.

Shock 2018 Oct 18. Epub 2018 Oct 18.

Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL.

Excessive microvascular permeability is a serious complication following hemorrhagic shock and resuscitation (HSR). S1P has been shown to ameliorate microvascular leakage in a model of combined alcohol intoxication and hemorrhagic shock and resuscitation (HSR). In the current study, we tested the hypothesis that S1P reduces HSR-induced microvascular leakage by preserving endothelial cell junctional structure and the endothelial glycocalyx through protection of mitochondrial function. Read More

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October 2018
1 Read

Military Supplement: Assessment of Coagulation Homeostasis in Blunt, Penetrating, and Thermal Trauma: Guidance for a Multi-Center Systems Biology Approach.

Shock 2018 Oct 18. Epub 2018 Oct 18.

US Army Institute of Surgical Research.

Introduction: Provisioning care for traumatically injured patients makes conducting research very proximal to injury difficult. These studies also inherently have regulatory barriers to overcome. Here we outline a protocol for acute-phase enrollment of traumatically injured patients into a prospective observational clinical trial with precise and comprehensive sample acquisition in support of a systems biology approach to a research study. Read More

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October 2018

Complex Feed-Forward and Feed-Back Mechanisms Underlie the Relationship Between Traumatic Brain Injury and the Gut-Microbiota-Brain Axis.

Shock 2018 Oct 17. Epub 2018 Oct 17.

Division of Trauma and Emergency Surgery, Department of Surgery, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.

Traumatic brain injury (TBI) contributes to nearly one in three injury-related deaths in the United States and accounts for a substantial public health burden and cost. The current literature reports that physiologic responses in the gastrointestinal system after TBI include, but are not limited to, epithelial barrier dysfunction, microbiota changes, and immunologic transformations. Recent evidence suggests gut alterations after TBI modify the homeostasis of the bidirectional gut-microbiota-brain axis, resulting in altered immune responses in the periphery and the brain. Read More

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October 2018

Dc-Sign Expression in Intestinal Epithelial Cells Regulates Sepsis-Associated Acute Intestinal Injury via Activating ERK1/2-NF-κB/P65 Signaling.

Shock 2018 Oct 17. Epub 2018 Oct 17.

Department of Emergency, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China.

Objective: The aim of the study was to investigate the role of dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN) in intestinal epithelial cells (IECs) in regulating sepsis-induced acute intestinal injury and systemic inflammatory response.

Methods: To induce sepsis condition, Male C57BL/6 mice were exposed to cecal ligation and puncture (CLP) in vivo, whereas a normal human IECs line (FHs74Int) was stimulated with lipopolysaccharide (LPS) in vitro. DC-SIGN siRNA pretreatment was used to knock down DC-SIGN expression both in vivo and in vitro. Read More

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October 2018
1 Read

Early Initiation of Continuous Renal Replacement Therapy Induces Fast Hypothermia and Improves Post-Cardiac Arrest Syndrome in a Porcine Model.

Shock 2018 Oct 17. Epub 2018 Oct 17.

Department of Emergency Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Rapid induction of hypothermia early after resuscitation can be an effective strategy against post-cardiac arrest syndrome (PCAS). Preliminary data suggested that continuous renal replacement therapy (CRRT) might be an efficient method to rapidly induce hypothermia. In this study, we investigated the efficacy of cooling induced by CRRT and its effects on the outcomes of PCAS in a porcine model. Read More

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October 2018
7 Reads

Single Low Dose of Human Recombinant Antithrombin (Atryn®) Has no Impact on Endotoxin-induced Disseminated Intravascular Coagulation: An Experimental Randomized Open Label Controlled Study.

Shock 2018 Oct 15. Epub 2018 Oct 15.

Univ Lille, INSERM UMR 1190 Translational Research for Diabetes, F-59000 Lille, France.

Background: Antithrombin III physiological levels are decreased during septic shock, and supplementation therapy could therefore be beneficial.

Objective: We hypothesized that the use of recombinant human antithrombin could reduce Disseminated Intravascular Coagulation (DIC) occurrence.

Methods: We conducted a randomized open label controlled experimental study. Read More

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October 2018
2 Reads
3.040 Impact Factor

Sepsis Induces Adipose Tissue Browning in Nonobese Mice But Not in Obese Mice.

Shock 2018 Nov;50(5):557-564

Division of Critical Care Medicine, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio.

Severe sepsis and septic shock are the biggest cause of mortality in critically ill patients. Obesity today is one of the world's greatest health challenges. Little is known about the extent of involvement of the white adipose tissue (WAT) in sepsis and how it is being modified by obesity. Read More

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November 2018
8 Reads

What's New in Shock, November 2018?

Shock 2018 Nov;50(5):501-503

Department of Trauma and Reconstructive Surgery, RWTH University Hospital, Aachen, Germany.

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November 2018

Exploring the Protective Role and the Mechanism of Sphingosine 1 Phosphate in Endotoxic Cardiomyocytes.

Shock 2018 Oct 8. Epub 2018 Oct 8.

Department of aged ICU, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.

FTY720 is a sphingosine 1 phosphate (S1P) receptor agonist approved for the treatment of multiple sclerosis (MS), which is a chronic inflammatory autoimmune disorder. Sepsis is a complex syndrome associated with progressive endotoxemic developments, which finally leads to damage of multiple organs, including the heart. In critical patients, cardiovascular dysfunction due to sepsis is a major cause of death. Read More

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October 2018
6 Reads

A New Echocardiographic Tool for Cardiac Output Evaluation: An Experimental Study.

Shock 2018 Oct 8. Epub 2018 Oct 8.

Caractéristiques Féminines des Dysfonctions des Interfaces Vasculaires, Univ Montpellier, Department of Emergency Medicine, Timone University Hospital, Marseille, France.

Background: The correlation between cardiac output (CO) evaluated by echocardiography and CO measured by thermodilution (COth) varies according to different studies. A new transthoracic echocardiography (TTE) tool allows automatic calculation of the subaortic velocity time index (VTIauto) and CO (COauto). The main objective was to evaluate the correlation between COth and COauto in an anesthetized, ventilated piglet hemorrhagic shock (HS) model. Read More

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October 2018
4 Reads

Effect of Long-Term Polytrauma on Ventilator-Induced Diaphragmatic Dysfunction in a Piglet Model.

Shock 2018 Oct 8. Epub 2018 Oct 8.

Department of Intensive and Intermediate Care, Medical Faculty, RWTH Aachen University, Aachen, Germany.

Introduction: Mechanical ventilation is known to activate oxidative stress and proteolytic pathways in the diaphragm. Trauma by inducing inflammation and activating proteolytic pathways may potentiate the effects of mechanical ventilation on the diaphragm. In a blunt chest trauma with concomitant injuries we tested the hypothesis that trauma via inflammation further activates the proteolytic pathways and worsens atrophy in the diaphragm. Read More

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October 2018
3 Reads

Distinct Dynamics of Stem and Progenitor Cells in Blood of Polytraumatized Patients.

Shock 2018 Oct 4. Epub 2018 Oct 4.

Institute of Molecular Medicine, Ulm University, Ulm 89081, Germany.

Endogenously mobilized stem and progenitor cells (SPCs) or exogenously provided SPCs are thought to be beneficial for trauma therapy. However, still little is known about the synchronized dynamics of the number of SPCs in blood after severe injury and parameters like cytokine profiles that correlate with these numbers. We determined the number of hematopoietic stem cells, common myeloid progenitors, granulocyte-macrophage progenitors and mesenchymal stem/stromal cells in peripheral blood (PB) 0-3 h, 8 h, 24 h, 48 h and 120 h after polytrauma in individual patients (injury severity score ≥ 21). Read More

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October 2018
4 Reads

Remote Intestinal Injury Early After Experimental Polytrauma and Hemorrhagic Shock.

Shock 2018 Oct 4. Epub 2018 Oct 4.

Institute of Clinical and Experimental Trauma Immunology, University Hospital of Ulm, Germany.

Dysfunction of the gut-blood barrier plays an important role in many diseases, such as inflammatory bowel disease, hemorrhagic shock (HS) or burn injury. However, little is known about gut barrier dysfunction after hemodynamically instable polytrauma (PT). Therefore, we aimed to evaluate the effects of PT and HS on remote intestinal damage and barrier dysfunction, especially regarding the role of Zonula occludens protein 1 (ZO-1) as an important tight junction protein. Read More

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October 2018
2 Reads

Early Differential Value of Plasma Presepsin on Infection of Trauma Patients.

Shock 2018 Oct 4. Epub 2018 Oct 4.

Department of Emergency, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China Beijing Key Laboratory of Cardiopulmonary Cerebral Resuscitation, Beijing, China.

Objective: Early differential diagnosis of an infection in a trauma patient is likely to have a significant influence on the prognosis. In the present study, we evaluated the early differential value of plasma presepsin, procalcitonin (PCT), C-reactive protein (CRP), and white blood cells (WBCs) on infection in trauma patients.

Methods: Trauma patients were divided into noninfected (n = 89) and infected trauma groups (n = 68); healthy adult volunteers (n = 60) and patients having sterile surgery (n = 60) were enrolled as the controls. Read More

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October 2018
5 Reads

Whole Exome Sequencing of Adult and Pediatric Cohorts of the Rare Vascular Disorder Systemic Capillary Leak Syndrome.

Shock 2018 Oct 4. Epub 2018 Oct 4.

Molecular Signal Transduction Section, Laboratory of Allergic Diseases, National Institute of Health, Institute of Allergy and Infectious Disease.

Objective: Systemic capillary leak syndrome (SCLS) is a rare disorder that presents with episodes of hypovolemic shock. The extent to which genetic abnormalities contribute to SCLS is unknown. We identified pediatric and adult cohorts with characteristic clinical courses. Read More

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October 2018
1 Read

Plasma Angiopoietin-2/-1 Ratio is Elevated and Angiopoietin-2 Levels Correlate with Plasma Syndecan-1 Following Pediatric Trauma.

Shock 2018 Oct 4. Epub 2018 Oct 4.

Division of Trauma and Acute Care Surgery, Department of Surgery, University of Alabama at Birmingham.

Background: Angiopoietin-1 (Agpt-1) and Agpt-2 are cytokine regulators of vascular endothelial integrity. Elevated plasma Agpt-2 levels and ratios of Agpt-2:Agpt-1 are associated with adverse outcomes in adult trauma and pediatric sepsis populations. However, the behavior of the angiopoietins after pediatric trauma has not been characterized, and their relationship to endothelial glycocalyx damage, indicated by plasma syndecan-1 (Syn-1) levels, has not been established. Read More

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October 2018

Endoplasmic Reticulum Stress-Induced NLRP1 Inflammasome Activation Contributes to Myocardial Ischemia/Reperfusion Injury.

Shock 2018 Oct 3. Epub 2018 Oct 3.

Department of Cardiovascular, Weihai Municipal Hospital, Weihai 264200, Shandong, China.

Studies have shown that Nod-like receptor protein (NLRP) 3 inflammasome activation contributes to myocardial ischemia/reperfusion (I/R) injury. However, the role and mechanism of NLRP1 inflammasome in myocardial I/R injury remains unknown. Endoplasmic reticulum (ER) stress is involved in the development of myocardial I/R injury. Read More

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October 2018
1 Read

Circulating Monocyte Counts and its Impact on Outcomes in Patients with Severe Sepsis Including Septic Shock.

Shock 2018 Oct 3. Epub 2018 Oct 3.

Department of Emergency Medicine, Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, South Korea.

This study was performed to evaluate the association of monocyte counts with mortality, the rate of bacteremia and organ dysfunction and to evaluate whether the change in monocyte counts from the premorbid state to sepsis would differ between survivors and non-survivors in patients with severe sepsis including septic shock. A retrospective analysis of patients with severe sepsis including septic shock was performed. Monocyte counts were categorized into < 250, 250 - 500, 500 - 750 and ≥ 750 cells/μL; in addition, 28-day mortality, the rate of bacteremia and organ dysfunction were compared between the groups. Read More

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October 2018
1 Read

The Role of Mitochondrial DNA in the Development of Ischemia Reperfusion Injury.

Shock 2019 Jan;51(1):52-59

Department of Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.

Ischemia/reperfusion (I/R) injury is a common occurrence resulting from acute mesenteric ischemia, traumatic or septic shock, burns, and surgical procedures that can lead to multiple organ failure and high mortality in critically ill patients. Mitochondria are often considered the cellular power factory via their capacity for ATP generation. Recently, mitochondria have been further identified as vital regulators of cell death, inflammation, and oxidative stress, all of which can aggravate I/R injury. Read More

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January 2019
2 Reads

Enhancing Autophagy Protects Against Sepsis-Induced Neuromuscular Dysfunction Associated with Qualitative Changes to Acetylcholine Receptors.

Shock 2018 Oct 3. Epub 2018 Oct 3.

Department of Anesthesiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Sepsis-induced myopathy is a heavy burden for patients during respiratory failure as well as after discharge, which could be characterized with qualitative changes to nAChR in a rat model of sepsis, regulated by NRG-1. Autophagy is an innate immune defense mechanism against microbial challenges. We found neuromuscular dysfunction in anterior tibial muscle of male Sprague-Dawley rats 24 h after cecal ligation and puncture (CLP). Read More

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October 2018
2 Reads

Lactate is a Prognostic Factor in Patients Admitted with Suspected ST-Elevation Myocardial Infarction.

Shock 2018 Oct 3. Epub 2018 Oct 3.

Department of Cardiology, The Heart Centre, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.

Aims: The diagnosis of cardiogenic shock depends on clinical signs of poor perfusion and low blood pressure. Lactate concentration will increase with poor tissue perfusion, and it has prognostic value in cardiogenic shock patients. We sought to assess the prognostic value of lactate concentration in subjects admitted with suspected ST-elevation myocardial infarction (STEMI). Read More

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October 2018
3 Reads

Angiopoietin Level Trajectories in Toddlers with Severe Sepsis and Septic Shock and Their Effect on Capillary Endothelium.

Shock 2018 Oct 3. Epub 2018 Oct 3.

Yale University, Department of Pediatrics, New Haven, CT.

Objective: Angiopoietins are postulated diagnostic biomarkers in children and adults with severe sepsis and septic shock. The diagnostic value of angiopoietins in children less than 5 years old has not been established, nor has their effect on permeability in the capillary microvasculature. We aim to determine if levels of angiopoietin-1 or -2 (angpt-1, -2) are diagnostic for severe sepsis/shock in young children and whether they affect the permeability of cultured human dermal microvascular endothelial cells (HDMEC). Read More

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October 2018
2 Reads

Late Peaks of HMGB1 and Sepsis Outcome: Evidence for Synergy With Chronic Inflammatory Disorders.

Shock 2018 Sep 19. Epub 2018 Sep 19.

2 Department of Critical Care Medicine, National and Kapodistrian University of Athens, Medical School, Athens, Greece.

High mobility group box 1 (HMGB1) is released from macrophages as a late biomarker of sepsis. Conditions associated with pre-existing macrophage activation may modify HMGB1 expression. This study aimed to assess the impact of HMGB1 kinetics on 28-day mortality. Read More

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September 2018
5 Reads

« Immunosuppression » is Inappropriately Qualifying the Immune Status of Septic and Sirs Patients.

Shock 2018 Sep 19. Epub 2018 Sep 19.

4th Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School - Athens, Greece.

Immunosuppression is the most commonly used concept to qualify the immune status of patients with either sterile systemic inflammatory response syndrome (SIRS) or sepsis. In this review we attempt to demonstrate that the concept of immunosuppression is an oversimplification of the complex anti-inflammatory response that occurs in patients dealing with a severe sterile or infectious insult. Particularly, the immune status of leukocytes varies greatly depending on the compartment from where they are derived from. Read More

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September 2018
1 Read

Myocardial Electrical Remodeling and the Arrhythmogenic Substrate in Hemorrhagic Shock-Induced Heart: Anti-Arrhythmogenic Effect of Liposome-Encapsulated Hemoglobin (HbV) on the Myocardium.

Shock 2018 Sep 19. Epub 2018 Sep 19.

Department of Chemistry, School of Medicine, Nara Medical University.

Introduction: Prolonged low blood pressure < 40 mmHg in hemorrhagic shock (HS) causes irreversible heart dysfunction, "Shock Heart Syndrome" (SHS), which is associated with lethal arrhythmias (VT/VF) leading to a poor prognosis.

Methods: To investigate whether the liposome-encapsulated human hemoglobin oxygen carrier (HbV) is comparable in effectiveness to autologous washed red blood cells (wRBCs) for improving arrhythmogenic properties in SHS, optical mapping analysis (OMP), electrophysiological study (EPS), and pathological examinations were performed in Sprague-Dawley rat hearts obtained from rats subjected to acute HS by withdrawing 30% of total blood volume. After acute HS, the rats were immediately resuscitated by transfusing exactly the same amount of saline (SAL), 5% albumin (5%ALB), HbV, or wRBCs. Read More

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September 2018
1 Read

Sepsis Increases Muscle Proteolysis in Severely Burned Adults, But Does Not Impact Whole-Body Lipid or Carbohydrate Kinetics.

Shock 2018 Sep 19. Epub 2018 Sep 19.

Department of Surgery, University of Texas Medical Branch, Galveston, Texas.

Sepsis is a common and often fatal consequence of severe burn injury, but its exact effects on whole body and muscle metabolism in the burn patient is unclear. To address this, 13 septic and 11 nonseptic patients (age: 36.9 ± 13. Read More

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September 2018
2 Reads