4,817 results match your criteria Shock[Journal]


Early Peritoneal Dialysis Ameliorates Blast Lung Injury by Alleviating Pulmonary Edema and Inflammation.

Shock 2019 Feb 6. Epub 2019 Feb 6.

Department of Nephrology, Daping Hospital, Research Institute of Surgery, Army University, Chongqing, China.

Background: Blast lung injury is a high-energy trauma with high mortality for explosion victims. A treatment for blast lung injury is still lacking. The aim of this study was to observe the efficacy and mechanism of peritoneal dialysis combined with glucocorticoids (GC) in the treatment of blast lung injury in rats. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001325DOI Listing
February 2019
3 Reads

Effect of Pravastatin Pretreatment and Hypercapnia on Intestinal Microvascular Oxygenation and Blood Flow During Sepsis.

Shock 2019 Feb 1. Epub 2019 Feb 1.

Department of Anesthesiology, University Hospital Duesseldorf, Moorenstrasse 5, 40225 Duesseldorf, Germany.

Introduction: In septic patients, adequate microvascular oxygenation (μHBO2) of the intestine is vital for their outcome. Recent studies suggest that statins can ameliorate septic microcirculation in a variety of tissues. However, the effect on intestinal microvascular oxygenation and blood flow is largely unknown. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001323DOI Listing
February 2019
2 Reads

High Central Venous-To-Arterial CO2 Difference is Associated With Poor Outcomes in Patients After Cardiac Surgery: A Propensity Score Analysis.

Shock 2019 Feb 1. Epub 2019 Feb 1.

Department of Cardio-Thoracic Surgery, Drum Tower Hospital Clinical Medical College of Nanjing Medical University, Nanjing, Jiangsu, China.

Purpose: In contrast to arterial lactate, previous studies have proposed central venous-to-arterial CO2 difference (P (v-a)CO2) as a more useful guide for categorizing patients at risk of developing septic shock. It is worthwhile studying P (v-a)CO2 in determining whether it could serve as a useful predictor for poor postoperative outcomes in patients undergoing cardiac surgery. We investigated the ability of P(v-a)CO2 to predict poor outcomes of patients with postoperative cardiogenic shock. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001324DOI Listing
February 2019
4 Reads

CCR5-Positive Inflammatory Monocytes are Crucial for Control of Sepsis.

Shock 2018 Dec 7. Epub 2018 Dec 7.

Department of Pharmacology and.

Neutrophils and inflammatory monocytes control sepsis by migration to the site of infection via their chemokine receptors. CCR5 is a chemokine receptor that is not expressed on neutrophils and inflammatory monocytes under homeostatic conditions. However, it has been demonstrated that CCR5 can become expressed on these cells during different models of inflammation. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001301DOI Listing
December 2018

Different Bactericidal and Inflammatory Activities of Human and Mouse Blood.

Shock 2018 Dec 7. Epub 2018 Dec 7.

Department of Pediatrics, Infectious Disease Unit, Massachusetts General Hospital, Shriners Hospital for Crippled Children, and Harvard Medical School, Boston, Massachusetts.

We performed side-by-side experiments to compare the behavior of four strains of Escherichia coli and one strain of Pseudomonas aeruginosa in fresh human and mouse blood. Bacteria multiplied in mouse whole blood and plasma but were killed in human whole blood and plasma. The percentage of granulocytes associated with fluorescence-labeled heat-killed E. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001302DOI Listing
December 2018
5 Reads

Burn-Induced Microglia Activation is Associated with Motor Neuron Degeneration and Muscle Wasting in Mice.

Shock 2018 Dec 6. Epub 2018 Dec 6.

Department of Anesthesiology, Critical Care and Pain Medicine, Massachusetts General Hospital, Shriners Hospital for Children, Boston and Harvard Medical School, Boston, MA, USA.

Introduction: Burn injury (BI) leads to both systemic and neuro-inflammation and is associated with muscle wasting and weakness, which increase morbidity and mortality. Disuse atrophy is concomitantly present in BI patients. Most studies have focused on muscle with little attention to role of central nervous system (CNS) in the neuromuscular changes. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001300DOI Listing
December 2018

Lipopolysaccharide Stress Induces Cryptic Exon Splice Variants of The Human Glucocorticoid Receptor.

Shock 2019 Jan 21. Epub 2019 Jan 21.

Shriners Hospitals for Children Northern California and Department of Surgery, University of California, Davis, Sacramento, CA 95817, USA.

Glucocorticoids are widely used in the treatment of numerous inflammatory conditions, including sepsis. Unfortunately, patient response to glucocorticoid therapy can be inconsistent. Variations in the human glucocorticoid receptor (hGR) may contribute to the differential patient response. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001318DOI Listing
January 2019

N-Acetylcysteine Ameliorates Gentamicin-Induced Nephrotoxicity by Enhancing Autophagy and Reducing Oxidative Damage in Miniature Pigs.

Shock 2019 Jan 14. Epub 2019 Jan 14.

Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Diseases, Beijing, China.

The clinical use of gentamicin over prolonged periods is limited because of dose- and time-dependent nephrotoxicity, in which intracellular oxidative stress and heightened inflammation have been implicated. Macroautophagy/autophagy is an essential and highly conserved self-digestion pathway that plays important roles in the maintenance of cellular function and viability under stress. The aim of this study was to determine changes in autophagy in response to the antioxidant N-acetylcysteine (NAC), via its effects on oxidative stress, inflammation, apoptosis, and renal function, following treatment with gentamicin in mini pigs. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001319DOI Listing
January 2019
3 Reads

Advanced Age Impairs Intestinal Antimicrobial Peptide Response and Worsens Fecal Microbiome Dysbiosis Following Burn Injury in Mice.

Shock 2019 Jan 18. Epub 2019 Jan 18.

Department of Surgery, Division of GI, Trauma and Endocrine Surgery, and Burn Research Program, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO 80045.

Maintenance of the commensal bacteria that comprise the gut microbiome is essential to both gut and systemic health. Traumatic injury, such as burn, elicits a number of changes in the gut, including a shift in the composition of the microbiome (dysbiosis), increased gut leakiness, and bacterial translocation into the lymphatic system and bloodstream. These effects are believed to contribute to devastating secondary complications following burn, including pneumonia, acute respiratory distress syndrome, multi-organ failure, and septic shock. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001321DOI Listing
January 2019
12 Reads
3.045 Impact Factor

Adenoviral βARKct Cardiac Gene Transfer Ameliorates Post-resuscitation Myocardial Injury in a Porcine Model of Cardiac Arrest.

Shock 2019 Jan 17. Epub 2019 Jan 17.

Department of Emergency, Shandong Provincial Hospital affiliated to Shandong University, Jinan, China.

Objective: To determine whether the inhibition of the G protein-coupled receptor kinase 2 by adenoviral βARKct cardiac gene transfer can ameliorate post-resuscitation myocardial injury in pigs with cardiac arrest (CA) and explore the mechanism of myocardial protection.

Methods: Male landrace domestic pigs were randomized into the sham group (Anesthetized and instrumented, but ventricular fibrillation was not induced) (n = 4), control group (ventricular fibrillation 8 min, n = 8) and βARKct group (ventricular fibrillation 8 min, n = 8). Hemodynamic parameters were monitored continuously. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001320DOI Listing
January 2019
6 Reads

Mitochondrial DNA: Innocent in Plasma, but Guilty in Urine?

Shock 2019 Feb;51(2):267

Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1097/SHK.0000000000001143DOI Listing
February 2019

Mitochondrial DNA: Innocent in Plasma, but Guilty in Urine?

Shock 2019 Feb;51(2):266

Department of Intensive Care Medicine, Radboud University Medical Center, Nijmegen, The Netherlands Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1097/SHK.0000000000001142DOI Listing
February 2019

What's New in Shock, February 2019?

Authors:
Lyle L Moldawer

Shock 2019 Feb;51(2):143-146

Sepsis and Critical Illness Research Center, Department of Surgery, University of Florida College of Medicine, Gainesville, Florida.

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http://dx.doi.org/10.1097/SHK.0000000000001292DOI Listing
February 2019

Mitochondrial Function in the Kidney and Heart, but not the Brain, is Mainly Altered in an Experimental Model of Endotoxaemia.

Shock 2019 Jan 9. Epub 2019 Jan 9.

Latvian Institute of Organic Synthesis, Aizkraukles Str. 21, Riga, LV-1006, Latvia.

Significant impairments in mitochondrial function are associated with the development of multi-organ failure in sepsis/endotoxaemia, but the data on the dynamics of simultaneous mitochondrial impairment in multiple organs are limited. The aim of this study was to evaluate the changes in heart, brain and kidney mitochondrial function in an experimental model of lipopolysaccharide (LPS)-induced endotoxaemia.Samples were collected 4 and 24 h after single injection of LPS (10 mg/kg) in mice. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001315DOI Listing
January 2019
1 Read

Comparison Between Continuous and Intermittent Administration of Hydrocortisone During Septic Shock: A Randomized Controlled Clinical Trial.

Shock 2019 Jan 7. Epub 2019 Jan 7.

Intensive Care Unit, University Hospital Taher Sfar Mahdia 5100, Tunisia.

Objectives: the best modality of administration of hydrocortisone during septic shock has been poorly evaluated and the guidelines remain unclear in this respect. This study aimed to compare bolus of hydrocortisone to a continuous infusion during septic shock.

Design: randomized controlled, open-label trial. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001316DOI Listing
January 2019
2 Reads
3.045 Impact Factor

The Contribution of The Omentum to the Outcome From Sepsis: An Experimental Animal Study.

Shock 2018 Dec 21. Epub 2018 Dec 21.

Division of Trauma, Critical Care, Burns and Acute Injury, Department of Surgery, School of Medicine, University of California, La Jolla, CA 92093, USA.

The omentum is a large mesenchymal fibro-fatty tissue with remarkable healing capability. It is also rich in immune cells, including macrophages, and lymphocytes, within particular structures named milky spots. Clinical observations indicate a high incidence of peritonitis after removal of the omentum suggesting that it may play a role in sepsis. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001311DOI Listing
December 2018
5 Reads

The Role of Macrophage Migration Inhibitory Factor in Remote Ischemic Conditioning Induced Hepatoprotection in A Rodent Model of Liver Transplantation.

Shock 2018 Dec 21. Epub 2018 Dec 21.

Department of Surgery and Transplantation, RWTH-Aachen University, Aachen, Germany.

Background: Macrophage migration inhibitory factor (MIF) is an important stress-regulating mediator of acute ischemia/reperfusion (I/R) injury and ischemic conditioning. The present study aimed to investigate whether MIF is involved in the effects of remote ischemic conditioning (RIC) in a rat model of orthotopic liver transplantation (OLT).

Methods: OLTs were performed in male Lewis rats (245-340 g). Read More

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http://dx.doi.org/10.1097/SHK.0000000000001307DOI Listing
December 2018
2 Reads

Protein Compositions Changes Of Circulating Microparticles In Patients With Valvular Heart Disease Subjected To Cardiac Surgery Contribute To Systemic Inflammatory Response and Disorder of Coagulation.

Shock 2018 Dec 21. Epub 2018 Dec 21.

Division of Cardiac Surgery, The First Affiliated Hospital of Sun Yat-sen University.

We recently demonstrated that circulating microparticles(MPs) from patients with valvular heart diseases (VHD) subjected to cardiac surgery impaired endothelial function and vasodilation. However, it is unknown whether or not the protein composition of these circulating MPs actually changes in response to the disease and the surgery. Circulating MPs were isolated from age-matched control subjects (n = 50) and patients (n = 50) with VHD before and 72 h after cardiac surgery. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001309DOI Listing
December 2018
1 Read
3.045 Impact Factor

Methane-Rich Saline Protects Against Sepsis-Induced Liver Damage by Regulating The PPAR-γ/NF-κB Signaling Pathway.

Shock 2018 Dec 21. Epub 2018 Dec 21.

Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an Shaanxi 710061, People's Republic of China.

Sepsis, a life-threatening organ dysfunction due to a dysregulated response to infection, is a common complication of major surgery. Previous studies have showed that methane possesses protective properties. This study aims to investigate the protective effect of methane-rich saline (MRS) on sepsis-induced liver injury. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001310DOI Listing
December 2018
3 Reads

Histone Deacetylase Inhibitors: A Novel Strategy In Trauma And Sepsis.

Shock 2018 Dec 21. Epub 2018 Dec 21.

Department of Surgery, University of Michigan, Ann Arbor, MI, USA.

Trauma remains a leading cause of morbidity and mortality among all age groups in the United States. Hemorrhagic shock and traumatic brain injury (TBI) are major causes of preventable death in trauma. Initial treatment involves fluid resuscitation to improve the intravascular volume. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001308DOI Listing
December 2018
1 Read

Hypoxia-Inducible Factor (HIF)-1α Promotes Inflammation and Injury Following Aspiration-Induced Lung Injury in Mice.

Shock 2018 Dec 24. Epub 2018 Dec 24.

Department of Surgery, University of Michigan, Ann Arbor, Michigan.

Acid aspiration-induced lung injury is a common disease in the intensive care unit (ICU) and acute respiratory distress syndrome (ARDS). Hypoxia-inducible factor (HIF)-1α is a major transcription factor responsible for regulating the cellular response to changes in oxygen tension. A clear understanding of the function of HIF-1α in lung inflammatory response is currently lacking. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001312DOI Listing
December 2018

Does Fenoldopam Protect Kidney in Cardiac Surgery? A Systemic Review and Meta-Analysis With Trial Sequential Analysis.

Shock 2018 Dec 26. Epub 2018 Dec 26.

Department of Critical Care Medicine, Zhongnan Hospital, Wuhan University, Wuhan 430071, Hubei Province, China.

Purpose: To assess the benefits and harms of fenoldopam for nephroprotective effects in adult patients undergoing cardiac surgery.

Methods: We conducted a systematic review with meta-analysis of randomized controlled trials (RCTs) comparing fenoldopam with placebo in cardiac surgery. Trials were systematically searched from Pubmed, EMBASE, CENTRAL and CNKI databases, up to July 30, 2018. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001313DOI Listing
December 2018

Function is Dissociated From Activation-Related Immunophenotype on Phagocytes From Patients With Sirs/Sepsis Syndrome.

Shock 2018 Dec 26. Epub 2018 Dec 26.

Unidad de Investigación Médica en Inmunoquímica. Centro Médico Nacional "Siglo XXI". Instituto Mexicano del Seguro Social. Cuauhtémoc Av. 330. Zip code 06720. Mexico City. Mexico.

Sepsis is a life-threatening condition associated with failure of at least one organ in the presence of infection. Along with SIRS, the acute systemic inflammatory syndrome without documented infection, sepsis represents a main health problem in intensive care units around the world. Hypercytokinemia and overexpression of activation-markers on leukocytes are frequently reported in SIRS/sepsis. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001314DOI Listing
December 2018
2 Reads

Effects of Landiolol in Lipopolysaccharide-Induced Acute Kidney Injury in Rats and In Vitro.

Shock 2018 Dec 18. Epub 2018 Dec 18.

Department of Anesthesiology and Intensive Care, Kagoshima University Hospital.

The mechanisms by which landiolol, an ultra-short-acting, selective β-1 blocker, could improve septic acute kidney injury (AKI) and how inflammation might affect mitochondrial function and cause the renal injury were examined. Male Wistar rats (250-300 g) were randomly allocated to three groups: a sham control group (n = 8); a lipopolysaccharide (LPS) group (n = 8); and an LPS + landiolol group (n = 8). LPS was administered intravenously at the start of the experiments; the LPS + landiolol group rats received LPS and continuous intravenous landiolol. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001306DOI Listing
December 2018
2 Reads

Systematic Identification and Analysis of Expression Profiles of mRNAs and IncRNAs in Macrophage Inflammatory Response.

Shock 2018 Nov 29. Epub 2018 Nov 29.

Guangdong Provincial Key Laboratory of Proteomics and State Key Laboratory of Organ Failure Research, Southern Medical University, Guangzhou 510515, China.

Long non-coding RNAs (lncRNAs), once thought to be transcriptional noise, have been recently shown to regulate a variety of biological processes. However, their roles in the inflammatory response are largely unexplored. In this study, we performed high-throughput sequencing to identify the profiles of mRNA and lncRNA transcriptomes in response to LPS stimulation, followed by a comprehensive bioinformatics analysis. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001181DOI Listing
November 2018
3.045 Impact Factor

Gut Barrier Dysfunction Induced by Aggressive Fluid Resuscitation in Severe Acute Pancreatitis is Alleviated by Necroptosis Inhibition in Rats.

Shock 2018 Dec 13. Epub 2018 Dec 13.

Department of Anesthesiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

Fluid resuscitation is the first-line antishock treatment in severe acute pancreatitis (SAP). Currently, although mentions of complications related to aggressive fluid resuscitation are very frequent, a lack of proper handling of complications remains. One of the most important complications is intestinal barrier injury, including intestinal ischemia-reperfusion injury following aggressive fluid resuscitation. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001304DOI Listing
December 2018
1 Read

Activation of AMP-Activated Protein Kinase by A769662 Ameliorates Sepsis-Induced Acute Lung Injury in Adult Mice.

Shock 2018 Dec 13. Epub 2018 Dec 13.

Division of Critical Care Medicine, Cincinnati Children's Hospital Medical Center and.

A serious consequence of sepsis is acute lung injury, whose severity is particularly impacted by the age of the patient. AMP-activated protein kinase (AMPK) is a crucial regulator of cellular metabolism, which controls mitochondrial biogenesis and autophagy. Here, we investigated the effect of pharmacological activation of AMPK with A769662 on lung injury by using a model that would preferably mimic the clinical condition of adult patients. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001303DOI Listing
December 2018

What's New in Shock, January 2019?

Authors:
Mark G Clemens

Shock 2019 Jan;51(1):1-3

Department of Biological Sciences, University of North Carolina at Charlotte, Charlotte, North Carolina.

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http://dx.doi.org/10.1097/SHK.0000000000001268DOI Listing
January 2019

Herpes Virus Entry Mediator (HVEM) Expression Promotes Inflammation/ Organ Injury in Response to Experimental Indirect-Acute Lung Injury.

Shock 2018 May 4. Epub 2018 May 4.

Div. of Surgical Research/Department of Surgery, Lifespan-Rhode Island Hospital and Brown University, Providence, RI, USA.

Therapeutic interventions to treat acute lung injury (ALI) remain largely limited to lung-protective strategies, as a real molecular pathophysiologically driven therapeutic intervention has yet to become available. While we have previously documented the expression of HVEM on leukocytes of septic mice and critically ill patients, its functional role in shock/sepsis-induced ALI has not yet been studied. Inasmuch; a murine model of indirect ALI (iALI) was induced by hemorrhagic shock (HEM) followed by cecal ligation and puncture (CLP), septic challenge and HVEM-siRNA or PBS was administrated by intra-tracheal instillation 2 hours after hemorrhage to determine the role of HVEM in the development of experimental iALI. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292778PMC
May 2018
1 Read

Partial Deletion of Tie2 Affects Microvascular Endothelial Responses to Critical Illness in a Vascular Bed and Organ-Specific Way.

Shock 2018 Jul 30. Epub 2018 Jul 30.

Department of Pathology and Medical Biology, Medical Biology section.

Tie2 is a tyrosine kinase receptor that is mainly expressed by endothelial cells. In animal models mimicking critical illness, Tie2 levels in organs are temporarily reduced. Functional consequences of these reduced Tie2 levels on microvascular endothelial behaviour are unknown. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001226DOI Listing
July 2018
10 Reads

Modulation of Peroxynitrite Reduces Norepinephrine Requirements in Ovine MRSA Septic Shock.

Shock 2018 Nov 28. Epub 2018 Nov 28.

Department of Anesthesiology, University of Texas Medical Branch, Galveston, Texas.

Vascular hypo-responsiveness to vasopressors during septic shock is a challenging problem. This study is to test the hypothesis that reactive nitrogen species (RNS), such as peroxynitrite, are major contributing factors to vascular hypo-responsiveness in septic shock. We hypothesized that adjunct therapy with peroxynitrite decomposition catalyst (PDC) would reduce norepinephrine requirements in sepsis resuscitation. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001297DOI Listing
November 2018
7 Reads

Pharmacological Inhibition of Pten Restores Remote Ischemic Postconditioning Cardioprotection in Hypercholesterolemic Mice: Potential Role of PTEN/AKT/GSK3β Signals.

Shock 2018 Nov 28. Epub 2018 Nov 28.

Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, China.

Although remote ischemic postconditioning (RIPC) was shown to confer cardioprotection against myocardial ischemia/reperfusion (I/R) injury in normal animals, whether RIPC-induced cardioprotection are altered in the presence of hypercholesterolemia, a comorbidity with acute myocardial infarction (AMI) patients, has yet to be determined. Normal or 2% cholesterol chow was fed to male C57BL/6J mice for 12 weeks to induce hypercholesterolemia, then normal or hypercholesterolemic murine hearts were exposed to AMI by coronary artery ligation. RIPC was induced by four episodes of 5 min femoral artery occlusion followed by 5 min reperfusion immediately after myocardial reperfusion in mice. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001296DOI Listing
November 2018
1 Read

Modulation of Endoplasmic Reticulum Stress Influences Ischemia-Reperfusion Injury After Hemorrhagic Shock.

Shock 2018 Nov 28. Epub 2018 Nov 28.

Department of Trauma Surgery, University of Heidelberg, Heidelberg, Germany.

Background: Impaired function of the endoplasmic reticulum (ER) results in ER stress, an accumulation of proteins in the ER lumen. ER stress is a major contributor to inflammatory diseases and is part of the pathomechanism of ischemia-reperfusion injury (IRI). Since severe traumatic injury is often accompanied by remote organ damage and immune cell dysfunction, we investigated the influence of ER stress modulation on the systemic inflammatory response and liver damage after hemorrhagic shock and reperfusion (HS/R). Read More

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http://dx.doi.org/10.1097/SHK.0000000000001298DOI Listing
November 2018

"Trans-Esophageal Doppler Assessment of Acute Hemodynamic Changes Due to Prone Positioning in Acute Respiratory Distress Syndrome Patients".

Shock 2018 Nov 20. Epub 2018 Nov 20.

Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGIMS), Lucknow, India.

Background: Effect of prone positioning on acute hemodynamic changes (within 10 minutes) in acute respiratory distress syndrome (ARDS) has not been studied.

Methods: In this prospective observational study, hemodynamic assessment by trans-esophageal Doppler (TED) was done with the primary aim to measure early changes in cardiac index (CI), if any, after prone positioning in moderate to severe ARDS patients. A subgroup analysis was also done based on the response to passive leg raise (PLR). Read More

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http://Insights.ovid.com/crossref?an=00024382-900000000-9771
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http://dx.doi.org/10.1097/SHK.0000000000001290DOI Listing
November 2018
11 Reads

What's New in Shock, March 2019?

Shock 2019 Mar;51(3):269-272

Department of Pulmonary, Critical Care, Allergy, and Sleep Medicine, Medical University of South Carolina, Charleston, South Carolina.

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http://dx.doi.org/10.1097/SHK.0000000000001291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375744PMC
March 2019
1 Read

Hemorrhage Attenuates Neutrophil Recruitment in Response to Secondary Respiratory Infection by Pseudomonas Aeruginosa.

Shock 2018 Nov 20. Epub 2018 Nov 20.

Division of Surgical Research, Department of Surgery, Rhode Island Hospital, Providence, RI 02903.

Neutrophil recruitment into the lung airspaces plays an important role in the containment and clearance of bacteria. Hemorrhagic shock, a complication of traumatic injury, induces immune dysfunction that compromises host defense and frequently leads to secondary infection. The objective of the current study was to determine whether prior hemorrhage impacts neutrophil recruitment in response to secondary Pseudomonas aeruginosa. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001288DOI Listing
November 2018
9 Reads

Dexmedetomidine Attenuates Acute Lung Injury Induced by Heatstroke and Improve Outcome.

Shock 2018 Nov 20. Epub 2018 Nov 20.

The Institute of Antibody Engineering, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515, P. R. China.

Introduction: Dexmedetomidine (DEX) has been demonstrated to inhibit inflammatory response and protect against multiorgan injury in various scenarios. The objectives of the present study was to ascertain whether DEX is able to attenuate acute lung injury (ALI) under heatstroke (HS), and to explore the underlying mechanism.

Methods: Male C57BL/6 mice were exposed to ambient temperature of 39. Read More

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http://Insights.ovid.com/crossref?an=00024382-900000000-9771
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http://dx.doi.org/10.1097/SHK.0000000000001289DOI Listing
November 2018
9 Reads

Comment From the Editorial Office on "Is Triple Self-Plagiarism "OK" if Only Made Transparent?"

Authors:
Mark G Clemens

Shock 2019 Jan;51(1):142

Center for Biomedical Science and Engineering, University of North Carolina at Charlotte, Charlotte, North Carolina.

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http://dx.doi.org/10.1097/SHK.0000000000001295DOI Listing
January 2019

Is Triple Self-Plagiarism "OK" If Only Made Transparent?

Authors:
Volker R Jacobs

Shock 2019 Jan;51(1):139

Department of Gynecology and Obstetrics (OB/GYN), Paracelsus Medical University (PMU), Salzburg, Austria.

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http://Insights.ovid.com/crossref?an=00024382-900000000-9770
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http://dx.doi.org/10.1097/SHK.0000000000001293DOI Listing
January 2019
1 Read

The Response to the Letter to the Editor Titled: "Is Triple Self-plagiarism "OK" If Only Made Transparent?" by Volker R Jacobs, MD, MBA.

Shock 2019 Jan;51(1):140-141

Ludwig Boltzmann Institute for Experimental and Clinical Traumatology in the AUVA Research Center, Vienna, Austria University of California School of Medicine, San Francisco, California Institute of Clinical and Experimental Trauma-Immunology, University Hospital of Ulm, Ulm, Germany Center for Inflammation Research, VIB, University Ghent, Ghent, Belgium Boston University School of Medicine, Boston, Massachusetts The William Harvey Research Institute, Barts and London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom Division of Critical Care Medicine, Cincinnati Children's Hospital Medical Center, College of Medicine, University of Cincinnati, Cincinnati, Ohio.

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http://dx.doi.org/10.1097/SHK.0000000000001294DOI Listing
January 2019
1 Read

A Novel Perfusion System for Damage Control of Hyperkalemia in Swine.

Shock 2018 Dec;50(6):677-683

Clinical Investigation Facility, David Grant USAF Medical Center, Travis Air Force Base, California.

Introduction: The standard of care for refractory hyperkalemia is renal replacement therapy (RRT). However, traditional RRT requires specialized equipment, trained personnel, and large amounts of dialysate. It is therefore poorly suited for austere environments. Read More

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http://Insights.ovid.com/crossref?an=00024382-900000000-9791
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http://dx.doi.org/10.1097/SHK.0000000000001079DOI Listing
December 2018
10 Reads

What's New in Shock, December 2018?

Authors:
Mark G Clemens

Shock 2018 Dec;50(6):613-615

University of North Carolina at Charlotte, Charlotte, North Carolina.

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http://dx.doi.org/10.1097/SHK.0000000000001264DOI Listing
December 2018

Do Sepsis-3 Criteria Facilitate Earlier Recognition of Sepsis and Septic Shock? A Retrospective Cohort Study.

Shock 2019 Mar;51(3):306-311

Department of Anesthesiology, University Hospital of Greifswald, Greifswald, Germany.

Background: New Sepsis-3 criteria are supposed to "facilitate earlier recognition … of patients with sepsis." To test this, we performed novel and direct comparisons of Sepsis-1 vs. Sepsis-3 criteria with respect to time differences of sepsis onset. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001177DOI Listing
March 2019
1 Read

Cardiac Effects of Hyperoxia During Resuscitation from Hemorrhagic Shock in Swine.

Shock 2018 Nov 6. Epub 2018 Nov 6.

Institut fu[Combining Diaeresis]r Ana[Combining Diaeresis]sthesiologische Pathophysiologie und Verfahrensentwicklung, Universita[Combining Diaeresis]tsklinikum Ulm, Ulm, Germany.

Hyperoxia (ventilation with FIO2 = 1.0) has vasoconstrictor properties, in particular in the coronary vascular bed, and, hence, may promote cardiac dysfunction. However, we previously showed that hyperoxia attenuated myocardial injury during resuscitation from hemorrhage in swine with coronary artery disease. Read More

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http://Insights.ovid.com/crossref?an=00024382-900000000-9771
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http://dx.doi.org/10.1097/SHK.0000000000001283DOI Listing
November 2018
13 Reads

MIR-190B Alleviates Cell Autophagy and Burn-Induced Skeletal Muscle Wasting via Modulating PHLPP1/AKT/FOXO3A Signaling Pathway.

Shock 2018 Nov 6. Epub 2018 Nov 6.

Burn Institute, the First Affiliated Hospital of PLA General Hospital, Beijing, 100048 China.

Introduction: Cell autophagy is an important material recycling process and is involved in regulating many vital activities under both physiological and pathological conditions. However, the mechanism of autophagy regulating burn-induced skeletal muscle wasting still needs to be elucidated.

Methods: The rat burn model with 30% total body surface area and L6 cell line were used in this study. Read More

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http://Insights.ovid.com/crossref?an=00024382-900000000-9771
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http://dx.doi.org/10.1097/SHK.0000000000001284DOI Listing
November 2018
7 Reads

The Effect of Nutrition on Early Stress-Induced Hyperglycemia, Serum Insulin Levels, and Exogenous Insulin Administration in Critically Ill Patients with Septic Shock: A Prospective Observational Study.

Shock 2018 Nov 6. Epub 2018 Nov 6.

Gelderse Vallei Hospital, Department of Intensive Care Medicine, Willy Brandtlaan 10, 6716 RP, Ede, the Netherlands.

Background: Stress-induced hyperglycemia is common among septic shock patients. Nutritional support influences glucose homeostasis but this effect has never been studied in septic shock. We aimed to determine the course of hyperglycemia and serum insulin levels in critically ill septic shock patients and to address the effects of caloric intake on glycemia, insulin levels, and exogenous insulin requirements. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001287DOI Listing
November 2018
6 Reads

Plasma Renin Concentration is Associated with Hemodynamic Deficiency and Adverse Renal Outcome in Septic Shock.

Shock 2018 Nov 6. Epub 2018 Nov 6.

From Department of Anesthesiology and Intensive Care, C.H.U. Dijon, France.

Background: In septic shock, both systemic vasodilatation and glomerular arteriole dilatation are responsible for the drop in glomerular filtration observed in early acute kidney injury. Angiotensin II has been showed to act on both mechanisms. Our objective was to evaluate the impact of renin angiotensin system activation, on hemodynamic deficiency and renal outcome in patient with septic shock and to assess whether urinary sodium could be a reliable test for high plasma renin concentration screening. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001285DOI Listing
November 2018
1 Read

Effect of Coagulation Factor Concentrates on Markers of Endothelial Cell Damage in Experimental Hemorrhagic Shock.

Shock 2018 Nov 29. Epub 2018 Nov 29.

Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, AUVA Trauma Research Center, Vienna.

Background: Plasma-based resuscitation showed protective effects on the endothelial glycocalyx compared to crystalloid resuscitation. There is paucity of data regarding the effect of coagulation factor concentrates (CFC) on the glycocalyx in hemorrhagic shock (HS). We hypothesized that colloid-based resuscitation supplemented with CFCs offers a therapeutic value to treat endothelial damage following HS. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001286DOI Listing
November 2018
9 Reads

Cirrhotic Patients Admitted to the ICU with Septic Shock: Factors Predicting Short and Long-Term Outcome.

Shock 2018 Nov 1. Epub 2018 Nov 1.

Service de Réanimation Médicale, Hospices Civils de Lyon, Hôpital Edouard Herriot, Lyon, France.

Cirrhotic patients with septic shock have a poor prognosis in ICU compared to general population of critically ill patients. Little is known about long-term outcome in these patients. We performed a retrospective analysis of a prospective cohort of cirrhotic patients with septic shock. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001282DOI Listing
November 2018
6 Reads

Incidence, Patient Characteristics, Mode of Drug Delivery, and Outcomes of Septic Shock Patients Treated with Vasopressors in the Arise Trial.

Shock 2018 Oct 30. Epub 2018 Oct 30.

Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.

Introduction: To describe the utilization of vasopressors (VP) in patients enrolled in the Australasian Resuscitation In Sepsis Evaluation (ARISE) trial, and to explore the association between time to VP and 90-day mortality.

Methods: The primary exposure variable was VP use after arrival in the emergency department (ED). Vasoactive agents considered as VP included: norepinephrine, epinephrine, metaraminol, or vasopressin. Read More

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http://Insights.ovid.com/crossref?an=00024382-900000000-9772
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http://dx.doi.org/10.1097/SHK.0000000000001281DOI Listing
October 2018
9 Reads