59,489 results match your criteria Sheng li ke xue jin zhan [Progress in physiology][Journal]


Incorporating non-biological factors into the TNM staging system for better prognostication and decision-making in testicular cancer.

World J Urol 2018 Dec 15. Epub 2018 Dec 15.

Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.

Background: We combined county-level socioeconomic status (SES), marital status and insurance status to introduce NBF-stage, which were further incorporated into the American Joint Committee on Cancer (AJCC) TNM staging system to generate an integrated staging system for better prognostication and decision-making for testicular cancer patients.

Methods: 15,324 eligible patients diagnosed with primary testicular cancer between January 1, 2007 and December 31, 2015 were strictly selected from the Surveillance, Epidemiology, and End Results (SEER) database. Independent survival predictors were determined based on Cox proportional hazards model. Read More

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December 2018

Molecular characterization and juvenile hormone-regulated transcription of the vitellogenin receptor in the cabbage beetle Colaphellus bowringi.

Comp Biochem Physiol A Mol Integr Physiol 2018 Dec 13. Epub 2018 Dec 13.

Hubei Insect Resources Utilization and Sustainable Pest Management Key Laboratory, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan 430070, China. Electronic address:

The vitellogenin receptor (VgR) is highly expressed in the ovaries where it is responsible for vitellogenin (Vg) deposition during oogenesis in insects. Therefore, identifying the VgR of insect pests, and understanding the mechanism regulating its expression, could lead to the development of pest management strategies based on disrupting reproduction. We cloned and identified VgR in the cabbage beetle, Colaphellus bowringi, which is a serious pest of cruciferous vegetables in Asia. Read More

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December 2018

Corrigendum to "Comparative analysis of novel autoantibody isotypes against citrullinatedinter-alpha-trypsin inhibitor heavy chain 3 (ITIH3) 542-556 peptide in serum from Taiwanese females with rheumatoid arthritis, primary Sjögren's syndrome and secondary Sjögren's syndrome in rheumatoid arthritis" [J Proteomics 141: (2016) 1-11].

J Proteomics 2018 Dec 12. Epub 2018 Dec 12.

School of Medical Laboratory Science and Biotechnology, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan; PhD Program for Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University and Academia Sinica, Taipei 11031, Taiwan. Electronic address:

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December 2018

Glycated Hemoglobin and Outcomes of Heart Failure (from Get With the Guidelines-Heart Failure).

Am J Cardiol 2018 Dec 3. Epub 2018 Dec 3.

Division of Cardiology, Ahmanson-UCLA Cardiomyopathy Center, University of California, Los Angeles, California. Electronic address:

Glycated hemoglobin (HbA) is a risk factor for new onset heart failure (HF). There is however a paucity of data evaluating its association with outcomes in patients with established HF. We assessed the relation of HbA with outcomes among hospitalized HF patients. Read More

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December 2018

Caffeine-stimulated muscle IL-6 mediates alleviation of non-alcoholic fatty liver disease.

Biochim Biophys Acta Mol Cell Biol Lipids 2018 Dec 12. Epub 2018 Dec 12.

Key Laboratory of Pu-erh Tea Science, the Ministry of Education, Yunnan Agricultural University, Kunming 650201, China; State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Kunming, China; Pu'erh Tea Research Institute, Pu'erh, China. Electronic address:

Caffeine intake is associated with a reduced risk developing non-alcoholic fatty liver disease (NAFLD), but the underlying molecular mechanisms remain to be fully elucidated. We report here that caffeine markedly improved high fat diet-induced NAFLD in mice resulting in a 10-fold increase in circulating IL-6 levels, leading to STAT3 activation in the liver. Interestingly, the expression of IL-6 mRNA was not increased in the liver, but increased substantially in the muscles of caffeine-treated mice. Read More

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December 2018
2 Reads

Extracorporeal shock wave lithotripsy is safe and effective for geriatric patients with chronic pancreatitis.

J Gastroenterol Hepatol 2018 Dec 14. Epub 2018 Dec 14.

Department of Gastroenterology, The Second Military Medical University, Shanghai, China.

Background & Aims: Pancreatic extracorporeal shock wave lithotripsy (P-ESWL) is first-line treatment for chronic pancreatitis (CP) patients with pancreatic stones. However, the performance of P-EWSL in geriatric patients remains unclear. We aimed to evaluate the safety and efficacy of P-ESWL for them. Read More

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December 2018

Effects of sartans and low-dose statins on cerebral white matter hyperintensities and cognitive function in older patients with hypertension: a randomized, double-blind and placebo-controlled clinical trial.

Hypertens Res 2018 Dec 14. Epub 2018 Dec 14.

Cardio-Cerebrovascular Control and Research Center, Institute of Basic Medicine, Shandong Academy of Medical Sciences, Jinan, Shandong, 250062, China.

Cerebral white matter hyperintensities (WMHs) and cognitive impairment are common in elderly hypertensive patients, and more needs to be learned about their prevention and treatment. Our aim was to investigate the effect of low-dose statins on WMH and cognitive function in elderly patients undergoing antihypertensive treatment. A total of 732 elderly hypertensive patients taking hydrochlorothiazide as their baseline medication were randomized using a 2 × 2 factorial design with antihypertensive (telmisartan vs. Read More

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December 2018

Enhanced photocatalytic simultaneous removals of Cr(VI) and bisphenol A over Co(II)-modified TiO2.

Langmuir 2018 Dec 14. Epub 2018 Dec 14.

To enhance the electron-hole separation and boost the practical performance of commercial titania (Degussa P25) under natural solar light, in this work, P25 was modified with Co(II) species (CoP25) through post-treatment with decomposition of Co-EDTA precursors in a wet chemical anchoring process. With appropriate Co(II) loading amount as molecular cocatalyst, the resulted CoP25-4 showed significantly improved photocatalytic performance for Cr(VI) reduction and bisphenol A (BPA) oxidation under UV-light irradiation. The co-existence of Cr(VI) and BPA promoted mutually the degradation of both pollutants. Read More

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December 2018

Enhanced stability and optical absorption in the perovskite-based compounds MA$_{1-x}$Cs$_x$PbI$_{3-y}$Br$_y$.

Chemphyschem 2018 Dec 12. Epub 2018 Dec 12.

Southwest University, School of Physical Science and Technology, Tian Sheng Lu 2#, 400715, Chongqing, CHINA.

Organometal halide perovskites have been outstanding from enormous amount of functional materials thanks to their highly cost-effective processability and prominent light harvesting capacity. Unfortunately, poor long-term stability seriously hinders their further development. The recent experimental observations suggest that Cesium is a promising candidate to enhance the stability of MAPbI$_3$. Read More

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December 2018

MicroRNA-7b attenuates ischemia/reperfusion-induced H9C2 cardiomyocyte apoptosis via the hypoxia inducible factor-1/p-p38 pathway.

J Cell Biochem 2018 Dec 11. Epub 2018 Dec 11.

Department of Cardiology, Zhongda Hospital, Medical School of Southeast University, Nanjing, China.

Objective: MicroRNAs (miRNAs) have been shown to play crucial roles in the occurrence, development, and treatment of many cardiovascular diseases. Coronary heart disease (CAD)-related miRNAs are still a growing research area. miR-7b was reported to be downregulated in acute myocardial infarction (AMI) myocardium tissues. Read More

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December 2018

Alterations in muscle activation patterns during robot-assisted bilateral training: A pilot study.

Proc Inst Mech Eng H 2018 Dec 14:954411918819115. Epub 2018 Dec 14.

2 Department of Exercise Sciences, The University of Auckland, Auckland, New Zealand.

Robot-assisted bilateral training is being developed as a new rehabilitation approach for stroke patients. However, there is still a lack of understanding of muscle functions when performing robot-assisted synchronous movements. The aim of this work is to explore the muscle activation patterns and the voluntary effort of participants during different robot-assisted bilateral training protocols. Read More

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December 2018

Training Augmented Intelligent Capabilities for Pharmacovigilance: Applying Deep-learning Approaches to Individual Case Safety Report Processing.

Pharmaceut Med 2018 13;32(6):391-401. Epub 2018 Oct 13.

1Celgene Corporation, 86 Morris Avenue, Summit, NJ 07901 USA.

Introduction: Regulations are increasing the scope of activities that fall under the remit of drug safety. Currently, individual case safety report (ICSR) collection and collation is done manually, requiring pharmacovigilance professionals to perform many transactional activities before data are available for assessment and aggregated analyses. For a biopharmaceutical company to meet its responsibilities to patients and regulatory bodies regarding the safe use and distribution of its products, improved business processes must be implemented to drive the industry forward in the best interest of patients globally. Read More

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October 2018

Using the health belief model to predict those seeking treatment for Hypoactive Sexual Desire Disorder among premenopausal women.

Taiwan J Obstet Gynecol 2018 Dec;57(6):791-795

Graduate School of Human Sexuality, Shu-Te University, Kaohsiung, Taiwan. Electronic address:

Objective: Hypoactive Sexual Desire Disorder (HSDD) was the most common subtype of female sexual dysfunction; however, little was known about why Chinese women with HSDD were willing to seek medical help. This study aimed to identify predictive factors of seeking treatment for HSDD.

Materials And Methods: 260 outpatient premenopausal women who met the DSM-IV-TR criteria for HSDD for at least 6 months were recruited. Read More

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December 2018

Advanced glycation end products of bovine serum albumin affect the cell growth of human umbilical vein endothelial cells via modulation of MEG3/miR-93/p21 pathway.

Acta Biochim Biophys Sin (Shanghai) 2018 Dec 13. Epub 2018 Dec 13.

Department of Cardiac Surgery, Ruijin Hospital, Shanghai, China.

Advanced glycation end products of BSA (AGE-BSA) contribute to the pathogenesis of diabetic vascular diseases. However, the roles and underlying mechanisms of AGE-BSA in diabetic vascular diseases remain largely unclear. Long non-coding RNAs (lncRNAs) are widely identified and known as gene regulators. Read More

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December 2018
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The Middle Road Less Taken: Electronic-Structure-Inspired Design of Hybrid Photocatalytic Platforms for Solar Fuel Generation.

Acc Chem Res 2018 Dec 13. Epub 2018 Dec 13.

Departments of Chemistry and Materials Science and Engineering , Texas A&M University , College Station , Texas 77842-3012 , United States.

The development of efficient solar energy conversion to augment other renewable energy approaches is one of the grand challenges of our time. Water splitting, or the disproportionation of HO into energy-dense fuels, H and O, is undoubtedly a promising strategy. Solar water splitting involves the concerted transfer of four electrons and four protons, which requires the synergistic operation of solar light harvesting, charge separation, mass and charge transport, and redox catalysis processes. Read More

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December 2018

Comparison of methods to identify modules in noisy or incomplete brain networks.

Brain Connect 2018 Dec 13. Epub 2018 Dec 13.

University of Helsinki, Helsinki Institute for Life Science , PO Box 56 , Helsinki, Finland , FIN-00014 ;

Community structure, or "modularity", is a fundamentally important aspect in the organisation of structural and functional brain networks, but their identification with community detection methods is confounded by noisy or missing connections. While several methods have been used to account for missing data, the performance of these methods has not been compared quantitatively so far. In this study, we compared four different approaches to account for missing connections when identifying modules in binary and weighted networks using both Louvain and Infomap community detection algorithms. Read More

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December 2018

Length-independent charge transport of well-separated single-crystal TiO long nanowire arrays.

Chem Sci 2018 Oct 6;9(37):7400-7404. Epub 2018 Aug 6.

College of Chemistry , Chemical Engineering and Materials Science , Soochow University , Suzhou 215123 , China . Email:

Long, well-separated single crystal TiO nanowire (NW) arrays with rapid charge transport properties hold great promise in photoelectrochemical and energy storage devices. Synthesis variations to increase the NWs length generally result in the widening of the NWs and fusion at their roots which, in turn, increases the structural disorder and slows charge transport. As such, well-separated single-crystal TiO NW arrays with rapid charge transport properties have been limited to lengths of about 3-4 μm. Read More

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October 2018
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Correction: design, synthesis and evaluation of cinnamic acid ester derivatives as mushroom tyrosinase inhibitors.

Medchemcomm 2018 May 10;9(5):897. Epub 2018 May 10.

School of Chemical and Environmental Engineering , Wuyi University , Jiangmen 529020 , China . Email:

[This corrects the article DOI: 10.1039/C8MD00099A.]. Read More

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Correlation of IL-1 and HB-EGF with endometrial receptivity.

Exp Ther Med 2018 Dec 9;16(6):5130-5136. Epub 2018 Oct 9.

Department of Clinical Laboratory, Yantai Yuhuangding Hospital, Yantai, Shandong 264000, P.R. China.

Fluctuations of interleukin-1β (IL-1β) and heparin-binding epidermal growth factor (HB-EGF) in endometrial receptivity were detected. Seventy-two patients receiving fertilization-embryo transfer (IVF-ET) for the first time in Yantaishan Hospital from July 2015 to September 2015 due to infertility were selected. The serum and follicular fluid of patients in ovulation-promoting cycle were collected; the levels of IL-1β and HB-EGF in serum and follicular fluid were detected via enzyme-linked immunosorbent assay (ELISA), and the levels of serum estradiol (E2), progesterone (P), follicle stimulating hormone (FSH) and luteinizing hormone (LH) were detected. Read More

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December 2018

Network analysis of differentially expressed smoking-associated mRNAs, lncRNAs and miRNAs reveals key regulators in smoking-associated lung cancer.

Exp Ther Med 2018 Dec 23;16(6):4991-5002. Epub 2018 Oct 23.

Department of Radiation Oncology, Zhejiang Key Laboratory of Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310000, P.R. China.

Lung cancer is the leading cause of cancer-associated mortality worldwide. Smoking is one of the most significant etiological contributors to lung cancer development. However, the molecular mechanisms underlying smoking-induced induction and progression of lung cancer have remained to be fully elucidated. Read More

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December 2018

[Research progress on environmental factors mediating apoptosis through MAPKsignaling pathway].

Authors:
L Sun X Li

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2018 Oct;36(10):796-800

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October 2018

[Research progress in the role and applications of microRNA in pulmonary fibrosis].

Authors:
J Y Wang Q Jia G C Yu

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2018 Oct;36(10):792-795

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October 2018

[Research progress on the effects of occupational noise exposure on cardiovascular systen].

Authors:
Y Fang J L Luo

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2018 Oct;36(10):789-792

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October 2018

[Applied study of Singapore occupational semi-quantitative risk assessment technique in occupational health risk assessment in a chair furniture manufacturing enterprise].

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2018 Oct;36(10):784-788

The Center for Disease Control and Prevention of Huzhou, Huzhou 313000, China.

To assess the occupational health risk level of a small-scale furniture manufacturer, and to explore the applicability of the Singapore-developed semi-quantitative occupational risk assessment model for chemical exposure (Singapore model) in small-scale furniture manufacturers, and to provide a basis for the continuous occupational health management of manufacturers. A small-scale furniture manufacturer was selected as the study subject; an on-site occupational hygiene investigation was performed on the above manufacturer during April to June in 2017, and a risk assessment was carried out using the Singapore model. The assessment results of the Singapore model indicated that risk levels of occupational exposure to harmful chemicals for the key positions in the workplace were inconsistent between the actual exposure level method and the exposure index method except for the following: high risk for formaldehyde exposure (risk level: 3. Read More

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October 2018

[Exposure analysis of accupational hazards in a chip production enterprise].

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2018 Oct;36(10):783-784

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October 2018

[High-dose mercury poisoning caused by intravenous injection: one case report].

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2018 Oct;36(10):780-782

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October 2018

[Determination of ethylenediamine in the air of workplace by Ion chromatography].

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2018 Oct;36(10):776-778

Provincial Center for Disease Control and Prevention, Nanjing 210009, China.

To establish a method to detect the concentrations of ethylenediamine in the air of workplace by Ion chromatography. Ethylenediamine in the air of workplace adsorpted by Silicone tube, then ultrasonic desorped by Sulfuric acid solution (0.1 mol/L) , the desorption solution qualitative and quantitative determination by Ion chromatography. Read More

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October 2018

[A study on the status and problem countermeasures of key occupational disease monitoring in Shandong, China, from 2015 to 2017].

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2018 Oct;36(10):769-773

Shandong Academy of Occupational Health and Occupational Medicine, Shandong Academy of Medical Sciences, Jinan 250062, China.

To analyze the completion status, monitoring results, and existing problems of key occupational disease monitoring in Shandong, China, from 2015 to 2017, and to provide reference materials for improving monitoring quality and carrying out occupational disease prevention and control. The monitoring situation including project coverage, data collection, monitoring results, and monitoring quality of key occupational diseases in Shandong from 2015 to 2017 were described and comparatively analyzed. In the past three years, the uncoverage rate of monitored counties (38. Read More

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October 2018

[Effect of multifunctional nursing single on reducing occupational back pain of nurses].

Authors:
S Q Ji Y Yuan P Chen

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2018 Oct;36(10):767-769

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October 2018

[Investigation of neck and shoulder pain among workers in an automobile plant].

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2018 Oct;36(10):764-767

Hubei Province Key Laboratory of Occupational Hazard Identification and Control, School of Public Health, Wuhan University of Science and Technology, Wuhan 430065, China.

To investigate the prevalence and risk factors of neck and shoulder pain (NSP) among automobile manufacturing workers and to provide a theoretical basis for prevention of NSP. From November 5 to November 19, 2017, a total 446 works who had worked for more than one year were recruited from an automobile plant by cluster sampling method. Chi square test and unconditional logistic regression were used to exam the relation between influencing factors and NSP. Read More

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October 2018

[Analysis of radiation workers health status in a city].

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2018 Oct;36(10):761-764

Hangzhou Hospital for the preverntion and Treatment of Occupational Diseases, Hangzhou 310014, China.

To investigate the health status of radiation workers in a city and provide evidence for the health management of radiation workers. To investigate the health status of radiation workers in a city and provide evidence for the health management of radiation workers. The majority of radiation workers are engaged in diagnostic radiology, male is more than female. Read More

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October 2018

[Analysis on chromosome aberration rate, micronucleus cell rate and related factors of 3021 radiation workers in Changzhou].

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2018 Oct;36(10):759-761

Changzhou Center for Disease Control and Prevention, Changzhou 213022, China.

To investigate the chromosomal aberration rate, micronucleus cell rate and the related factors of radiation workers in Changzhou, provide evidence for the occupational health and safety of radiation workers. Descriptive analysis of the chromosomal aberration rate, micronucleus cell rate and the related factors of 3021 radiation workers who conducted occupational health examination in the Changzhou Center for Disease Control and prevention in 2017, multivariate logistic regression was used to analyze the data. The abnormal rate of chromosome aberration and micronucleus cells of 3021radiation workers in Changzhou were 1. Read More

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October 2018

[Occupational characteristics and clinical manifestations of 245 cases of occupational brucellosis].

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2018 Oct;36(10):755-758

HulunBuir People's Hospital, Department of Brucellosis, HulunBuir Clinical Medical College, Inner Mongolia University for Nationalitie, HulunBuir 021008, China.

To analyse epidemiological, clinical characteristics and laboratory examination results of 245 occupational brucellosis form 2008 to 2018, which providing theoretical basis for prevention and control of occupational brucellosis. Based on the China Center for Disease Control and Prevention Information System, a database of occupational brucellosis cases in HunlunBuir from January 2008 to July 2018 was established. The Epidemiological characteristics, Clinical manifestation, laboratory examination of 245 occupational brucellosis and 359 without occupational brucellosis were comparatively analyzed about the same period. Read More

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October 2018

[The correlation between job satisfaction and emotional labor surface performance of nurses in emergency department].

Authors:
H H Yin W J Wang

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2018 Oct;36(10):752-754

Qilu Hospital of Shandong University, Jinan 250012, China.

To investigate the relationship between job satisfaction and emotional labor surface performance of nurses in emergency department of Shandong province, and to provide realistic basis for the nursing management to develop targeted improvement measures. The general situation questionnaire and emotional labor scale were used to investigate 276 emergency department nurses in 10 comprehensive hospitals in Shandong province. The internal satisfaction and external satisfaction scores of the nurses in the emergency department were respectively (3. Read More

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October 2018

[Preliminary study on the evaluation of pneumoconiosis].

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2018 Oct;36(10):749-752

School of Medicine and Life Sciences, University of Jinan, Shandong Academy of Medical Sciences, Jinan 250062, China.

Select the appropriate disease assessment indicators, formulate the comprehensive evaluation group of pneumoconiosis patients, and explore the role of the comprehensive evaluation grouping in the clinical evaluation of pneumoconiosis, and provide the basis for the prognosis of pneumoconiosis. Combined with clinical symptoms, pulmonary function, pneumoconiosis stage, acute exacerbation and complications, a comprehensive assessment of pneumoconiosis patients was established.138 newly diagnosed pneumoconiosis patients were divided into low risk group, middle risk group and (very) high risk group. Read More

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October 2018

[An analysis of the evaluation results of symptom checklist 90 for female medical workers].

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2018 Oct;36(10):745-748

Institute of Occupational Health, Beijing Municipal Center for Disease Prevention and Control, Beijing Research Center for Preventive Medicine, Beijing 100020, China.

To evaluate the mental health of female doctors and nurses. Investigat the psychologic status of female doctors and nurses using symptom checklist 90. And statistical software was applied to analyze results of symptom checklist 90. Read More

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October 2018

[Prevalence of dyslipidemia and risk factors among coal miners under different work conditions].

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2018 Oct;36(10):742-745

Institute of Occupation Disease Prevention and Control, Xishan Coal and Electricity (Group) Limited Company, Taiyuan 030053, China.

To understand the prevalence of dyslipidemia and risk factors among coal miners under different work conditions. The survey was conducted from April 2016 to June 2016. 759 mine workers were divided into three groups (group of the front line miner, underground auxiliary and ground) . Read More

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October 2018

[A bibliometric analysis of China's occupational health standard from 2001 to 2016].

Authors:
T Liu Y Lu Q H Zhu

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2018 Oct;36(10):738-741

National Instithue of Occupational Health and Poison Control, Chinese Center for Disease Control and Prevesion, Beijing 100050, China.

To analyze the relevant literature on China's occupational health standard from 2001 to 2016, and to provide a basis for further improving China's occupational health standard system. Wanfang Data, CNKI, VIP, PubMed, Embase, and Web of Knowledge were used to retrieve relevant literature on China's occupational health standard from 2001 to 2016. Information of the literature was collected, and type of literature, time and region, first author's affiliation, and research funding were analyzed by bibliometrics. Read More

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October 2018

[Investigation on the status of multidrug-resistant gram-negative bacteria induced by occupational exposure among medical staff in ICU].

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2018 Oct;36(10):734-737

Tianjin centers for Disease Control and Prevention, Tianjin 300011, China.

To understand the natural carriage status of multidrug resistant gram-negative bacteria in ICU medical personmel and control growp of 69 hospitals in Tianjin. From April 2007 to October 2016, 2902 samples of nasal vestibule and hand swabs were collected from 1296 ICU medical personmel and 155 non medical personmel (control group) , and 14 kinds of antimicrobial agents were used to test the sensitivity of gram-negative bacilli. 332 Gram-negative bacteria were isolated from medical personmel, of which 139 were multidrug resistant; 70 gram-negative bacteria were isolated from control group, and 20 of which were multidrug resistant. Read More

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October 2018

[Effect of biofeedback therapy on metabolic syndrome under different levels of job stress].

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2018 Oct;36(10):728-733

Department of Public Health Management, Tianjin 4th Center Hospital, Tianjin 300140, China.

To investigate the effect of biofeedback therapy on metabolic syndrome (MS) and the effect of different levels of job stress on the outcome. The physicians in tertiary hospitals who were diagnosed with MS from January to December, 2016 were divided into biofeedback group and health education group according to different intervention methods, and moderate group, medium group, and high group according to different levels of job stress. A 6month intervention was implemented from May to October, 2017. Read More

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October 2018

[The effects of resveratrol on mitochondrial biogenesis dysfunction induced by fluoride in human neuroblastoma SH-SY5Y cells].

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2018 Oct;36(10):721-727

Department of Occupational and Environmental Health, School of Public Health, MOE Key Lab of Environment and Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

To explore the role of mitochondrial biogenesis and the neuroprotective mechanism of resveratrol in fluoride neurotoxicity. SH-SY5Y cells in exponential phase were treated with different concentrations (20, 40, 60 mg/L) of sodium fluoride (NaF) for 24 h. Co-treatment with 60 mg/L NaF, 20 μmol/L resveratrol (RSV) was administrated in the resveratrol intervene trial. Read More

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October 2018

EGCG Reduces Obesity and White Adipose Tissue Gain Partly Through AMPK Activation in Mice.

Front Pharmacol 2018 22;9:1366. Epub 2018 Nov 22.

Key Laboratory of Puer Tea Science, Ministry of Education, Yunnan Agricultural University, Kunming, China.

(-)-Epigallocatechin-3-gallate (EGCG), which is the most abundant catechin in green tea, has many potential health benefits, including decreased weight gain and/or adipose tissue weight. Suggested mechanisms for body weight reduction by EGCG include: (1) a decrease in calorie intake and (2) activation of AMPK in liver, skeletal muscle, and white adipose tissue. However, only one study supports the AMPK hypothesis. Read More

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November 2018

Recent Advances in Herbal Medicines for Digestive System Malignancies.

Front Pharmacol 2018 20;9:1249. Epub 2018 Nov 20.

Jilin Provincial Key Laboratory on Molecular and Chemical Genetic, The Second Hospital of Jilin University, Changchun, China.

Herbal medicines, as an important part of traditional Chinese medicine (TCM), have been used to treat digestive system malignancies (DSM) for many years, and have gradually gained recognition worldwide. The role of herbal medicines in the comprehensive treatment of DSM is being improved from adjuvant treatment of the autologous immune function in cancer patients, to the treatment of both the symptoms and disease, direct inhibition of tumor cell growth and proliferation, and induction of tumor cell autophagy and apoptosis. Their specific mechanisms in these treatments are also being explored. Read More

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November 2018

Prediction of finger kinematics from discharge timings of motor units: implications for intuitive control of myoelectric prostheses.

J Neural Eng 2018 Nov 29. Epub 2018 Nov 29.

School of Mechanical Engineering, Shanghai Jiao Tong University, Shanghai, CHINA.

<i>Objective</i>. The aim of the study was to characterize the accuracy in the identification of motor unit discharges during natural movements using high-density electromyography (EMG) signals and to investigate their correlation with finger kinematics. <i>Approach</i>. Read More

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November 2018

Leucine regulates slow-twitch muscle fibers expression and mitochondrial function by Sirt1/AMPK signaling in porcine skeletal muscle satellite cells.

Anim Sci J 2018 Dec 6. Epub 2018 Dec 6.

Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu, Sichuan, PR China.

A previous study demonstrated that leucine upregulates the slow myosin heavy chain mRNA expression in C2C12 cells. However, the role of leucine in slow-twitch muscle fibers expression and mitochondrial function of porcine skeletal muscle satellite cells as well as its mechanism remain unclear. In this study, porcine skeletal muscle satellite cells cultured in differentiation medium were treated with 2 mM leucine for 3 days. Read More

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December 2018

CRISPR/Cas9-mediated PD-1 disruption enhances human mesothelin-targeted CAR T cell effector functions.

Cancer Immunol Immunother 2018 Dec 6. Epub 2018 Dec 6.

Sheng Yushou Center of Cell Biology and Immunology, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 800 Dongchuan Road, Minghang, Shanghai, 200240, China.

The interaction between programmed cell death protein 1 (PD-1) on activated T cells and its ligands on a target tumour may limit the capacity of chimeric antigen receptor (CAR) T cells to eradicate solid tumours. PD-1 blockade could potentially enhance CAR T cell function. Here, we show that mesothelin is overexpressed in human triple-negative breast cancer cells and can be targeted by CAR T cells. Read More

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December 2018

A CREB1/miR-433 reciprocal feedback loop modulates proliferation and metastasis in colorectal cancer.

Aging (Albany NY) 2018 Dec 6. Epub 2018 Dec 6.

Department of General Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

Increasing evidence has indicated the prognostic value of miR-433 across a series of malignancy types. However, the underlying mechanisms involved in cancer progression haven't been sufficiently elucidated. In the present work, we found that miR-433 was downregulated in CRC tissues and cell lines. Read More

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December 2018