64,785 results match your criteria Sharp Force Injuries


Developing a Process for Returning Medically Actionable Genomic Variants to Latino Patients in a Federally Qualified Health Center.

Public Health Genomics 2018 Dec 6:1-8. Epub 2018 Dec 6.

Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA.

Aim: To develop a process for returning medically actionable genomic variants to Latino patients receiving care in a Federally Qualified Health Center.

Methods: Prior to recruitment, researchers met with primary care providers to (1) orient clinicians to the project, (2) establish a process for returning actionable and nonactionable results to participants and providers through the electronic health record, and (3) develop a process for offering clinical decision support for follow-up education and care. A Community Advisory Board was engaged to provide input on recruitment strategies and materials for conveying results to participants. Read More

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December 2018
2 Reads

The impact of dam flushing event on dissolved trace elements concentrations: Coupling integrative passive sampling and discrete monitoring.

Sci Total Environ 2018 Nov 22;656:433-446. Epub 2018 Nov 22.

Irstea, UR RiverLy, centre de Lyon-Villeurbanne, 5 rue de la Doua, CS 20244, F-69625, Villeurbanne Cedex, France.

Sediments accumulation in reservoirs induces water storage capacities reduction and flood risks increases rendering dam flushing or dredging events compulsory for security reasons. Short transient events like dam flushing monitoring is still a great challenge because the suspended sediments and contaminants concentrations increases could occur over only few hours/days and cover tens of kilometres. Since 1942, 21 dam flushing events have been performed on the Upper Rhône River (from Lake Geneva in Switzerland to Lyon in France) in order to evacuate accumulated sediments behind the Verbois dam (Switzerland). Read More

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November 2018

Conducting the Neural Symphony of Memory Replay.

Neuron 2018 Dec;100(5):1016-1019

Neuroscience Program, Department of Psychology and Volen National Center for Complex Systems, Brandeis University, Waltham, MA, 02453, USA. Electronic address:

Hippocampal sharp-wave ripple oscillations and sequence replay events are important for memory. Ramirez-Villegas et al. present a model that dissects cellular mechanisms of SWR generation in the CA3-CA1 circuit, and explains the network features of slow-gamma coordination and sequence replay. Read More

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December 2018

Nanocone-based plasmonic metamaterials.

Nanotechnology 2019 Feb;30(5):055301

Department of Physics and London Centre for Nanotechnology, King's College London, Strand, London, WC2R 2LS, United Kingdom.

Metamaterials and metasurfaces provide unprecedented opportunities for designing light-matter interactions. Optical properties of hyperbolic metamaterials with meta-atoms based on plasmonic nanorods, important in nonlinear optics, sensing and spontaneous emission control, can be tuned by varying geometrical sizes and arrangement of the meta-atoms. At the same time the role of the shape of the meta-atoms forming the array has not been studied. Read More

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February 2019

Bladder hematoma: a complication from an oocyte retrieval procedure.

JBRA Assist Reprod 2018 Dec 6. Epub 2018 Dec 6.

Fertipraxis-Centro de Reprodução Humana- RJ, Brazil.

Introduction: More than one million fertilization cycles are performed every year. The incidence of serious complications associated with transvaginal oocyte pick-up is low, but the procedure is not risk-free. Risks are inherent to procedures in which thin needles and sharp instruments are introduced into the vaginal wall and ovarian capsule to access the ovaries. Read More

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December 2018
2 Reads

Temporarily quadrupling the dose of inhaled steroid to prevent asthma exacerbations: FAST.

Health Technol Assess 2018 Dec;22(70):1-82

Respiratory Medicine, Nottingham NIHR Biomedical Research Centre, University of Nottingham, Nottingham, UK.

Background: Asthma exacerbations affect the quality of life of patients with asthma and have a major effect on the overall costs of asthma care. An asthma self-management plan that advises the temporary quadrupling of inhaled corticosteroid dose may prevent asthma exacerbations, but this needs to be confirmed before being adopted widely.

Objectives: To compare the clinical effectiveness and cost-effectiveness of an asthma self-management plan that advises patients to temporarily quadruple the dose of inhaled corticosteroid when asthma control starts to deteriorate with a standard self-management plan. Read More

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December 2018

Alpinia calcarata: potential source for the fabrication of bioactive silver nanoparticles.

Nano Converg 2018 Dec 6;5(1):37. Epub 2018 Dec 6.

Department of Botany, Bioresource Tech Laboratory, Guru Ghasidas Vishwavidyalaya, Bilaspur, Chhattisgarh, 495009, India.

In the present study silver nanoparticles fabricated by using leaf extract of Alpinia calcarata. We have also studied the effect of various experimental parameters viz., metal ion concentration, pH and incubation period on nanoparticle biosynthesis. Read More

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December 2018
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Tailoring Fano lineshapes using plasmonic nanobars for highly sensitive sensing and directional emission.

Phys Chem Chem Phys 2018 Dec 6. Epub 2018 Dec 6.

Guangdong Provincial Key Laboratory of Nanophotonic Functional Materials and Devices, School of Information and Optoelectronic Science and Engineering, South China Normal University, Guangzhou 510006, China.

Plasmonic oligomers are one class of the most promising nanoclusters for generating Fano resonances. This study reveals that a nanobar-based heptamer concurrently sustains triple polarization-dependent Fano resonances, in sharp contrast to traditional nanodisk or nanosphere-based counterparts. Benefiting from the enhanced near field and reduced spectral linewidth, the gold heptamer exhibits a high refractive index sensitivity (940 nm per RIU) together with a figure of merit (FoM) value as large as 20. Read More

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December 2018

Creutzfeldt-Jakob Disease Presenting as Nonconvulsive Status Epilepticus.

Case Rep Neurol Med 2018 4;2018:3092018. Epub 2018 Nov 4.

Department of Neurology and Neurosurgery, University of Tartu, Estonia.

Creutzfeldt-Jakob disease is a rare, rapidly progressive spongiform encephalopathy in humans. EEG plays an important role in diagnosing this disease. In some patients, epileptic activity and encephalopathy from various aetiologies may share morphological features on EEG. Read More

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November 2018
2 Reads

Comparative Analysis of vlhA Promoters.

Front Genet 2018 21;9:569. Epub 2018 Nov 21.

Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Russia.

is an intracellular parasite affecting respiratory tract of poultry that belongs to class Mollicutes. features numerous variable lipoprotein hemagglutinin genes (vlhA) that play a role in immune escape. The vlhA promoters have a set of distinct properties in comparison to promoters of the other genes. Read More

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November 2018
1 Read

Histological chorioamnionitis and developmental outcomes in very preterm infants.

J Perinatol 2018 Dec 5. Epub 2018 Dec 5.

Division of Obstetrics and Gynaecology, University of Western Australia, Perth, WA, Australia.

Objective: To characterize the association of histological chorioamnionitis (HCA) with neurodevelopmental outcomes in children born at <30 weeks gestation.

Study Design: This retrospective cohort study included infants born 2006-2012 in whom placental histopathology, neonatal outcomes, and Bayley-III assessment at age 2 years were available. We assessed the association of HCA exposure with cognitive, language, and motor delay with logistic regression models adjusted for gestational age, sex, small for gestational age and brain injury. Read More

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December 2018
1 Read

-mediated knock-out of DNAJC14 verifies this chaperone as a pivotal host factor for RNA replication of Pestiviruses.

J Virol 2018 Dec 5. Epub 2018 Dec 5.

University of Luebeck, Institute of Virology and Cell Biology, Luebeck, Germany

Pestiviruses like bovine viral diarrhea virus (BVDV) are a thread to livestock. For pestiviruses cytopathogenic (cp) and non-cytopathogenic (noncp) strains are distinguished in cell culture. The noncp biotype of BVDV is capable of establishing persistent infections which is a major problem in disease control. Read More

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December 2018
2 Reads

Socio-economic and age variations in response to supermarket-led checkout food policies: a repeated measures analysis.

Int J Behav Nutr Phys Act 2018 Dec 5;15(1):125. Epub 2018 Dec 5.

MRC Epidemiology Unit & Centre for Diet and Activity Research, University of Cambridge, Cambridge, UK.

Background: Dietary inequalities between population groups are common with older and more affluent individuals tending to have healthier diets. Differential responses to health interventions may exacerbate inequalities. Changing what foods are displayed at supermarket checkouts is one intervention that has the potential to change diets. Read More

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December 2018
1 Read

Simultaneous chloroplast, mitochondria isolation and mitochondrial protein preparation for two-dimensional electrophoresis analysis of Ice plant leaves under well watered and water-deficit stressed treatments.

Protein Expr Purif 2018 Nov 30. Epub 2018 Nov 30.

Department of Biochemistry and Molecular Biology, MS 200, University of Nevada, Reno, NV, 89557, USA.

This paper presents a simultaneous isolation of pure, intact chloroplasts and mitochondria from mature leaves of Ice plant (Mesembryanthemum crystallinum) and mitochondrial protein preparation for two-dimensional electrophoresis (2DE) analysis under well watered and water -deficit stressed treatments. The washed chloroplasts and mitochondria were purified with Percoll gradients prepared using a Master flex R pump. The chloroplast and mitochondrial proteins were extracted in lysis buffer containing a protease inhibitor mix supplemented with 1 μM Leupeptin and 1 μM E64, followed by precipitation with ice-cold acetone. Read More

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November 2018

Analysis of an open source, closed-loop, realtime system for hippocampal sharp-wave ripple disruption.

J Neural Eng 2018 Dec 3;16(1):016009. Epub 2018 Dec 3.

Department of Electrical and Computer Engineering, Rice University, Houston, TX, United States of America.

Objective: The ability to modulate neural activity in a closed-loop fashion enables causal tests of hypotheses which link dynamically-changing neural circuits to specific behavioral functions. One such dynamically-changing neural circuit is the hippocampus, in which momentary sharp-wave ripple (SWR) events-≈  100 ms periods of large 150-250 Hz oscillations-have been linked to specific mnemonic functions via selective closed-loop perturbation. The limited duration of SWR means that the latency in systems used for closed-loop interaction is of significant consequence compared to other longer-lasting circuit states. Read More

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December 2018

Amisulpride for very late-onset schizophrenia-like psychosis: the ATLAS three-arm RCT.

Health Technol Assess 2018 Nov;22(67):1-62

Medical Research Council Population Health Research Unit, University of Oxford, Oxford, UK.

Background: Very late-onset (aged ≥ 60 years) schizophrenia-like psychosis (VLOSLP) occurs frequently but no placebo-controlled, randomised trials have assessed the efficacy or risks of antipsychotic treatment. Most patients are not prescribed treatment.

Objectives: The study investigated whether or not low-dose amisulpride is superior to placebo in reducing psychosis symptoms over 12 weeks and if any benefit is maintained by continuing treatment thereafter. Read More

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November 2018
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Association of baseline peptidylarginine deiminase 4 autoantibodies with favorable response to treatment escalation in rheumatoid arthritis.

Arthritis Rheumatol 2018 Dec 3. Epub 2018 Dec 3.

VA Nebraska-Western Iowa Health Care System, Omaha, NE, 68105.

Objective: To determine if the baseline presence of autoantibodies to peptidylarginine deiminase 4 (PAD4) predicts therapeutic response to biologic and conventional disease-modifying antirheumatic drugs (DMARDs) in patients with rheumatoid arthritis (RA) who failed methotrexate (MTX) monotherapy.

Methods: Baseline serum from 282 RA patients who failed MTX monotherapy were screened for the presence of anti-PAD4 antibodies by immunoprecipitation. Clinical response to either triple DMARD (MTX, sulfasalazine, and hydroxychloroquine) or MTX-etanercept combination therapy was determined at 24- and 48-weeks post-treatment initiation. Read More

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December 2018

Plant DNases are potent therapeutic agents against Echis carinatus venom-induced tissue necrosis in mice.

J Cell Biochem 2018 Dec 2. Epub 2018 Dec 2.

Department of Studies in Biochemistry, University of Mysore, Manasagangothri, Mysuru, India.

Echis carinatus envenomation leads to severe tissue necrosis at the bitten site by releasing DNA from immune cells that blocks the blood flow. An earlier report has shown that exogenous DNase 1 offers protection against such severe local tissue necrosis. Tricosanthus tricuspidata is a medicinal plant and the paste prepared from its leaves has been used extensively for the treatment of snakebite-induced tissue necrosis. Read More

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December 2018

Consultant led peer assisted learning model.

Clin Teach 2018 Dec 2. Epub 2018 Dec 2.

University of Exeter Medical School, Exeter, UK.

Background: Undergraduate medical students frequently report inadequate basic surgical skills such as suturing and knot tying. In recent years, peer assisted learning (PAL) has proven to be an effective method of teaching basic surgical skills. The consistency of the teaching and the quality of the content may be questionable in these workshops. Read More

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December 2018

OS1 functions in the allocation of nutrients between the endosperm and embryo in maize seeds.

J Integr Plant Biol 2018 Dec 1. Epub 2018 Dec 1.

State Key Laboratory of Agrobiotechnology and National Maize Improvement Center, Department of Plant Genetics and Breeding, China Agricultural University, Beijing, China.

Uncovering the genetic basis of seed development will provide useful tools for improving both crop yield and nutritional value. However, the genetic regulatory networks of maize (Zea mays) seed development remain largely unknown. The maize opaque endosperm and small germ 1 (os1) mutant has opaque endosperm and a small embryo. Read More

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December 2018
1 Read

Functional Heterogeneity of CD4 Tumor-Infiltrating Lymphocytes With a Resident Memory Phenotype in NSCLC.

Front Immunol 2018 16;9:2654. Epub 2018 Nov 16.

Sanquin Research, Department of Hematopoiesis, and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.

Resident memory T cells (T) inhabit peripheral tissues and are critical for protection against localized infections. Recently, it has become evident that CD103 T are not only important in combating secondary infections, but also for the elimination of tumor cells. In several solid cancers, intratumoral CD103CD8 tumor infiltrating lymphocytes (TILs), with T properties, are a positive prognostic marker. Read More

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November 2018

Life after : The decline of exotic suspension feeder may have significant impacts on lake ecosystems.

J Great Lakes Res 2018 Aug;44(4):650-659

United States Environmental Protection Agency, Great Lakes National Program Office, Chicago, IL, USA, , 312-886-2405,

It is well documented that the introduction of dreissenid bivalves in eutrophic lakes is usually associated with decreases in turbidity and total phosphorus concentrations in the water column, concomitant increases in water clarity, as well as other physical changes to habitat that may have cascading effects on other species in the invaded waterbody. In contrast, there is a paucity of data on the ecological ramifications of the elimination or decline of dreissenids due to pollution, bottom hypoxia, or other mechanisms. Using data collected by the U. Read More

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Herpes simplex encephalitis and pseudotumour cerebri due to ısotretinoin.

J Pak Med Assoc 2018 Dec;68(12):1833-11835

Department of Internal Medicine, Medical School, Firat University, Elazig Turkey.

Isotretinoin can have significant adverse reactions on multiple systems. We report a unique case of pseudotumour cerebri and herpes encephalitis resulting due to isotretinoin. A 19-year-old female patient was admitted to our clinic, presenting with headache, nausea, vomiting and fever since three days. Read More

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December 2018
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Unravelling the role of vacancies in lead halide perovskite through electrical switching of photoluminescence.

Nat Commun 2018 Nov 30;9(1):5113. Epub 2018 Nov 30.

Institute of Advanced Materials (INAM), Universitat Jaume I, 12006, Castello, Spain.

We address the behavior in which a bias voltage can be used to switch on and off the photoluminescence of a planar film of methylammonium lead triiodide perovskite (MAPbI) semiconductor with lateral symmetric electrodes. It is observed that a dark region advances from the positive electrode at a slow velocity of order of 10 μm s. Here we explain the existence of the sharp front by a drift of ionic vacancies limited by local saturation, that induce defects and drastically reduce the radiative recombination rate in the film. Read More

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November 2018
1 Read

Individual Genetic Variation Might Predict Acute Skin Reactions in Women Undergoing Adjuvant Breast Cancer Radiotherapy.

Anticancer Res 2018 Dec;38(12):6763-6770

Department of Oncology, Ryhov County Hospital, Jönköping, Sweden.

Adverse skin reactions during radiotherapy (RT) are common. The aim of this study was to explore whether genetic variation might be linked to acute radiation skin reactions (ARSR).

Materials And Methods: One hundred and nineteen women undergoing adjuvant RT for breast cancer were included. Read More

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December 2018

Trends in Insomnia Diagnosis and Treatment Among Medicare Beneficiaries, 2006-2013.

Am J Geriatr Psychiatry 2018 Nov 2. Epub 2018 Nov 2.

Department of Neurology (SET), Columbia University, New York.

Objective: Insomnia is an important clinical problem affecting the elderly. We examined trends in insomnia diagnosis and treatment among Medicare beneficiaries over an eight-year period.

Methods: This was a time-series analysis of Medicare administrative data for years 2006-2013. Read More

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November 2018

The use of anthropogenic marine debris as a nesting material by brown boobies (Sula leucogaster).

Mar Pollut Bull 2018 Dec 11;137:96-103. Epub 2018 Oct 11.

Institute for Marine and Antarctic Studies, University of Tasmania, 20 Castray Esplanade, Battery Point, Tasmania 7004, Australia; Bird Group, Department of Life Sciences, The Natural History Museum, Akeman Street, Tring, Hertfordshire HP23 6AP, United Kingdom.

Marine debris is pervasive worldwide, and affects biota negatively. We compared the characteristics of debris incorporated within brown booby (Sula leucogaster) nests throughout their pantropical distribution by assessing the type, colour and mass of debris items within nests and in beach transects at 18 sites, to determine if nests are indicators of the amount of debris in local marine environments. Debris was present in 14. Read More

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December 2018

Trajectory planning and tracking control of a ground mobile robot: A reconstruction approach towards space vehicle.

ISA Trans 2018 Nov 20. Epub 2018 Nov 20.

State Key Laboratory of Automotive Simulation and Control, Jilin University, Changchun, PR China; Department of Control Science and Engineering, Jilin University, Changchun, PR China. Electronic address:

With the development of the similarity calculation method, the orbital motion of space vehicle can be translated into a sequence of waypoints that reflect position and velocity on the ground. In this paper, a motion control system is proposed to make the mobile robot pass through the desired waypoints for reconstructing the orbital motion. First, the parameterized trajectory optimization method is applied to generate a curvature-continuous trajectory from the waypoints, the position and velocity demands are presented as the equality constraints. Read More

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November 2018

Concomitant use of levofloxacin and fluconazole leading to possible torsades de pointes.

J Oncol Pharm Pract 2018 Nov 30:1078155218815743. Epub 2018 Nov 30.

1 College of Pharmacy, University of Illinois at Chicago, Chicago, USA.

Prolongation of the corrected QT interval can lead to the deadly arrhythmia torsades de pointes. There are many risk factors for corrected QT prolongation, one being medication. The goal of this case report is to add to the limited literature surrounding the possibility of torsades de pointes when levofloxacin and fluconazole are used concomitantly. Read More

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November 2018

A simple atomic force microscope-based method for quantifying wear of sliding probes.

Rev Sci Instrum 2018 Nov;89(11):113708

Department of Mechanical Engineering and Materials Science, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA.

Sliding wear is particularly problematic for micro- and nano-scale devices and applications, and is often studied at the small scale to develop practical and fundamental insights. While many methods exist to measure and quantify the wear of a sliding atomic force microscope (AFM) probe, many of these rely on specialized equipment and/or assumptions from continuum mechanics. Here we present a methodology that enables simple, purely AFM-based measurement of wear, in cases where the AFM probe wears to a flat plateau. Read More

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November 2018

Frequency and wavelet based analyses of partial and complete measure synchronization in a system of three nonlinearly coupled oscillators.

Chaos 2018 Nov;28(11):113108

Plasma Physics Division, Saha Institute of Nuclear Physics, HBNI, 1/AF Bidhannagar, Kolkata 700064, India.

Measure Synchronization (MS) is the generalization of synchrony to Hamiltonian Systems. Partial measure synchronization (PMS) and complete measure synchronization in a system of three nonlinearly coupled one-dimensional oscillators have been investigated for different initial conditions on the basis of numerical computation. The system is governed by the classical SU(2) Yang-Mills-Higgs (YMH) Hamiltonian with three degrees of freedom. Read More

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November 2018

[Invasive Fusariosis: Report of Three Cases in Peru].

Rev Peru Med Exp Salud Publica 2018 Jul-Sep;35(3):523-526

Hospital Nacional Guillermo Almenara. Lima, Perú.

Fusarium species are a group of fungi that cause superficial infections, locally invasive and disseminated disease, which occur mainly in immunocompromised hosts, and occasionally in immunocompetent individuals. We present three cases that show three different clinical forms of Fusarium spp. disease that affected different types of patients (patients with hematological malignancy, chronic kidney disease in peritoneal dialysis and post-surgical for osteoarticular pathology), each with its own characteristics that merit discussion. Read More

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October 2017
1 Read

Combination of fixative agents and fixation times to visually differentiate the cortical from the medullary layer in bovine adrenal glands.

An Acad Bras Cienc 2018 Oct-Dec;90(4):3887-3891

Departamento de Zootecnia, Faculdade de Ciências Agrárias e Veterinárias, Universidade Estadual Paulista/UNESP, Via de acesso Paulo Donato Castelane, s/n, 14884-900 Jaboticabal, SP, Brazil.

Chronic stress exposure commonly increases adrenals weight and changes their morphology. This study aimed to compare four methods to delimitate the cortical and medullary layers of adrenals glands in Nelore bulls. Fresh adrenals did not present differentiation between layers. Read More

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May 2018
1 Read

Lower Extremity Injuries in Ice Hockey: Current Concepts.

Am J Orthop (Belle Mead NJ) 2018 Nov;47(11)

Columbia University, Center for Shoulder, Elbow and Sports Medicine, 622 W 168th Street, 11th Floor, New York, New York 10032, USA. Email:

Ice hockey is a fast-paced, collision sport requiring tremendous skill and finesse, yet ice hockey can be a harsh and violent game. It has one of the highest musculoskeletal injury rates in all of competitive sports. Razor sharp skates, aluminum sticks and boards made from high density polyethylene (HDPE), all contribute to the intrinsic hazards of the game. Read More

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November 2018
1 Read

Traumatic insemination is not the case in three Orius species (Heteroptera: Anthocoridae).

PLoS One 2018 5;13(12):e0206225. Epub 2018 Dec 5.

Division of Insect Sciences, The National Agriculture and Food Research Organization (NARO), Tsukuba, Japan.

Traumatic insemination (TI) is an extraordinary style of mating behavior wherein the female integument is pierced by the male extragenital structure to transfer the spermatozoa into the female's body through wounding. Flower bugs of the genus Orius belong to the family Anthocoridae (Heteroptera), which is referred to as the "TI family". Males possess sharp shaped extragenitalia, and females receive the extragenitalia using the copulatory tubes, which are specialized extragenital structures in Orius species. Read More

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December 2018

[THE STRUCTURE AND RISK OF CHRONIC MORBIDITY IN SOME VILLAGES OF THE UPPER IMERETI REGION OF WEST GEORGIA AND THEIR MOLECULAR AND CYTOGENETIC MARKERS].

Georgian Med News 2018 Oct(283):97-103

David the Builder University of Georgian; Tbilisi State Medical University; Beritashvili Center of Experimental Biomedicine; Sachkhere District Hospital, Georgia.

The purpose of our study was to identify the nature of the cause-effect relationship between the risks of developing of Chronic Obstructive Pulmonary Disease (COPD) and Cardio-vascular Disease (CVD) in patients residing in the villages of Chiatura district, characterized by varying degrees of environmental stress. The residents (n=400) of the Chiatura district living in the villages, Khreiti, Perevisa and Rgani were examined. The villages are characterized by different degrees of ecological tension (the villages differ both in their remoteness from sources of environmental pollution - manganese mining quarries and the scale of its extraction, which allows them to rank according to the degree of environmental tension: Khreiti - low, Perevis - medium, Rgani - high). Read More

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October 2018
2 Reads

Silicon-Mediated Selective Homo- and Hetero-Coupling of Carbon Monoxide.

J Am Chem Soc 2018 Dec 5. Epub 2018 Dec 5.

While the transformation of carbon monoxide to multicarbon compounds (fuels and organic bulk chemicals) via reductive scission of the enormously strong CO bond is dominated by transition-metals, splitting and deoxygenative reductive coupling of CO under nonmatrix conditions using silicon, the second most abundant nonmetal of the Earth's crust, is extremely scarce and mechanistically not well understood. Herein we report the selective deoxygena-tive homocoupling of carbon monoxide by divalent silicon utilizing the (LSi:)2Xant 1a (Xant = 9,9-dimethyl-xanthene-4,5-diyl; L = PhC(NtBu)2) and (LSi:)2Fc 1b (Fc = 1,1'-ferrocenyl) as four-electron reduction reagents under mild reaction conditions (RT, 1 atm), affording the corresponding disilylketenes, Xant(LSi)2(µ-O)(µ-CCO) 2a and Fc(LSi)2(µ-O)(µ-CCO) 2b, respectively. However, the dibenzofuran analogue of 1b, compound 1c, was unreactive towards CO due to the longer distance between the two SiII atoms, which demonstrated the crucial role of the Si∙∙∙Si distance on cooperative CO binding and activation. Read More

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December 2018
2 Reads

Confronting Challenges in Reducing Heart Failure 30-Day Readmissions: Lessons Learned With Implications for Evidence-Based Practice.

Worldviews Evid Based Nurs 2018 Dec 5. Epub 2018 Dec 5.

Sharp Memorial Hospital, San Diego, CA, USA.

Background: Heart failure (HF) is considered a condition in which a portion of hospital admissions are preventable if timely and appropriate outpatient care management occurs. Facility readmission rates for HF are reportable and subject to penalty. Both military and civilian healthcare systems have fiscal responsibility and are accountable for successful disease management. Read More

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December 2018

Design of a Novel Electrode of Radiofrequency Ablation for Large Tumors: In Vitro Validation and Evaluation.

J Biomech Eng 2018 Dec 5. Epub 2018 Dec 5.

Mem. ASME, Tumor Ablation Group, Biomedical Science and Technology Research Center, School of Mechatronic Engineering and Automation, Shanghai University, Shanghai 200444, China.

In the present study, a monopolar expandable electrode (MEE) in radiofrequency ablation (RFA) proposed in our previous study was validated and evaluated using the in vitro experiment and computer simulation. Two commercial RF electrodes (conventional electrode, CE and umbrella electrode, UE) was used to compare the ablation results with MEE using the in vitro egg white model (experiment and computer simulation) and in vivo liver tumor model (computer simulation) to verify the efficacy of MEE in the large tumor ablation. The sharp increase in impedance during RFA procedures was taken as the termination of RFA protocols. Read More

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December 2018
1 Read

Solution-Controlled Conformational Switching of an Anchored Wireframe DNA Nanostructure.

Small 2018 Dec 5:e1803628. Epub 2018 Dec 5.

Biomaterials, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Solnvägen 9, 171 65, Solna, Sweden.

Self-assembled DNA origami nanostructures have a high degree of programmable spatial control that enables nanoscale molecular manipulations. A surface-tethered, flexible DNA nanomesh is reported herein which spontaneously undergoes sharp, dynamic conformational transitions under physiological conditions. The transitions occur between two major macrostates: a spread state dominated by the interaction between the DNA nanomesh and the BSA/streptavidin surface and a surface-avoiding contracted state. Read More

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December 2018
1 Read

The BMP2/4 ortholog Dpp can function as an inter-organ signal that regulates developmental timing.

Life Sci Alliance 2018 Dec 19;1(6):e201800216. Epub 2018 Nov 19.

Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA.

Developmental transitions are often triggered by a neuroendocrine axis and can be contingent upon multiple organs achieving sufficient growth and maturation. How the neurodendocrine axis senses the size and maturity of peripheral organs is not known. In larvae, metamorphosis is triggered by a sharp increase in the level of the steroid hormone ecdysone, secreted by the prothoracic gland (PG). Read More

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December 2018

Sexual Behavior of Perinatally Infected Youth in Northwest Ethiopia: Implication for HIV Prevention Strategy.

AIDS Res Treat 2018 1;2018:1573845. Epub 2018 Nov 1.

Public Health Department, Medicine and Health Sciences College, Debre Markos University, Debre Markos, Ethiopia.

Background: The major mode of HIV transmission in many resource-limited settings is via heterosexual intercourse, but the primary risk factor for youth is primarily through perinatal infection. With the maturing of the HIV epidemic, youth who acquired the virus perinatally are now reaching adolescence and becoming young adults. There is a paucity of data on the sexual practices of perinatally infected youth in Ethiopia. Read More

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November 2018
3 Reads

Autoantibodies to Peptidylarginine Deiminase 2 Are Associated With Less Severe Disease in Rheumatoid Arthritis.

Front Immunol 2018 20;9:2696. Epub 2018 Nov 20.

Division of Rheumatology, The Johns Hopkins University School of Medicine, Baltimore, MD, United States.

Peptidylarginine deiminases (PAD) 2 and 4 are key enzymes in rheumatoid arthritis (RA) pathogenesis due to their ability to generate the protein targets of anti-citrullinated protein antibodies (ACPA). Anti-PAD4 antibodies that cross-react with PAD3 (anti-PAD3/4) have been identified and are associated with severe joint and lung disease. Here, we examined whether anti-PAD2 antibodies were present in patients with RA and defined their clinical significance. Read More

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November 2018

ANNALS EXPRESS: Hematopoietic alterations in neonates with congenital diaphragmatic hernia receiving extracorporeal membrane oxygenation support.

Ann Clin Biochem 2018 Dec 4:4563218820052. Epub 2018 Dec 4.

Department of Neonatology and Pediatric Critical Care Medicine, University of Bonn Children's Hospital.

Background Extracorporeal membrane oxygenation procedure (ECMO) has been established in the therapy of respiratory insufficient infants with congenital diaphragmatic hernia (CDH). In CDH newborns, a delay in transfer to an ECMO center is associated with a sharp increase in mortality. Predictive factors for ECMO support are urgently needed. Read More

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December 2018

Exploring dry storage as an alternative biobanking strategy inspired by Nature.

Theriogenology 2018 Nov 26;126:17-27. Epub 2018 Nov 26.

Laboratory of Embryology, Faculty of Veterinary Medicine, Campus Coste San Agostino, University of Teramo, Teramo, Italy.

Biobanking is a rapidly growing industry, covering diverse fields such as human medicine, farm animal production, laboratory animals record keeping, and wildlife conservation. Presently, biobanking is done almost exclusively by cryopreservation, followed by maintenance of the samples under liquid nitrogen. Cryopreservation has satisfactory efficiency but it comes with a host of problems, and the process is highly species-specific. Read More

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November 2018

Toward high-contrast AFM-TERS imaging: nano-antenna-mediated remote-excitation on sharp-tip silver nanowire probes.

Nano Lett 2018 Dec 4. Epub 2018 Dec 4.

The tip-enhanced Raman spectroscopy (TERS) imaging technique is designed to provide correlated morphological and chemical information with a nanoscale spatial resolution by utilizing the plasmonic resonance supported by metallic nanostructures at the tip apex of a scanning probe. However, limited by the scattering cross-sections of these nanostructures, only a small fraction of the incident light can be coupled to the plasmonic resonance to generate Raman signals. The uncoupled light then directly excites background spectra with a diffraction-limited resolution, which becomes the background noise that often blurs the TERS image. Read More

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December 2018

Thermodynamics of the Air-Water Interface of Mixtures of Surfactants with Polyelectrolytes, Oligoelectrolytes and Multivalent Metal Electrolytes.

J Phys Chem B 2018 Dec 4. Epub 2018 Dec 4.

A full comparison of results from binding isotherms and surface tension (ST) measurements on polyelectrolyte (PE)-surfactant (S) mixtures, especially the polymer dependence, shows up clear distinctions between the behaviour of two representative PE-S systems, poly(sodium styrenesulfonate) (NaPSS) with dodecyltrimethylammonium bromide (CTAB) and poly(dimethyl-diallyl-ammonium chloride) (PDMDAAC) with sodium dodecylsulfate (SDS) in 100 mM NaCl. The surfactant-monomer binding constant in NaPSS-CTAB is an order of magnitude greater than that in the PDMDAAC-SDS system. This results in the ST behaviour being dominated largely by non-cooperativity in the former and by cooperativity in the latter. Read More

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December 2018
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Neuromyotonia in a horse.

J Vet Intern Med 2018 Dec 3. Epub 2018 Dec 3.

Department of Veterinary Clinical Sciences, School of Veterinary Medicine and Animal Sciences, Sao Paulo State University (Unesp), Botucatu, Sao Paulo, Brazil.

This article describes the clinical and electromyographic findings of neuromyotonia in a 19-month-old male crossbred Quarter Horse that presented with stiffness and muscle asymmetry in the hind limbs as well as sacrococcygeal, paravertebral, and gluteal myokymia. An electromyographic study showed spontaneous continuous muscle fiber activity with high-frequency discharges, fibrillations, positive sharp waves, fasciculation potentials, and complex repetitive discharges. Histological examination of the gluteal muscle showed a mixed neurogenic and myopathic pattern. Read More

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December 2018