838 results match your criteria Shared Psychotic Disorder

Syntactic complexity of spoken language in the diagnosis of schizophrenia: A probabilistic Bayes network model.

Schizophr Res 2022 Jun 22. Epub 2022 Jun 22.

Robarts Research Institute, Western University, London, Ontario, Canada; Lawson Health Research Institute, London, Ontario, Canada; Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, Quebec, Canada; Department of Psychiatry, Schulich School of Medicine and Dentistry, Western University, London, Canada; Department of Medical Biophysics, Western University, London, Canada.

In the clinical linguistics of schizophrenia, syntactic complexity has received much attention. In this study, we address whether syntactic complexity deteriorates within the six months following the first episode of psychosis in those who develop a diagnosis of schizophrenia. We collected data from a cohort of twenty-six first-episode psychosis and 12 healthy control subjects using the Thought and Language Index interview in response to three pictures from the Thematic Apperception Test at first assessment and after six months (the time of consensus diagnosis). Read More

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Multimodal data fusion of cortical-subcortical morphology and functional network connectivity in psychotic spectrum disorder.

Neuroimage Clin 2022 May 23;35:103056. Epub 2022 May 23.

Tri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS) - Georgia State University, Georgia Institute of Technology, and Emory University, Atlanta, GA, USA; The Mind Research Network, Lovelace Biomedical and Environmental Research Institute, Albuquerque, USA; Department of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, USA; Department of Computer Science, Georgia State University, Atlanta, USA; Department of Psychology, Georgia State University, Atlanta, USA.

Multiple authors have noted overlapping symptoms and alterations across clinical, anatomical, and functional brain features in schizophrenia (SZ), schizoaffective disorder (SZA), and bipolar disorder (BPI). However, regarding brain features, few studies have approached this line of inquiry using analytical techniques optimally designed to extract the shared features across anatomical and functional information in a simultaneous manner. Univariate studies of anatomical or functional alterations across these disorders can be limited and run the risk of omitting small but potentially crucial overlapping or joint neuroanatomical (e. Read More

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Hierarchical Symptom Components in Early Psychosis.

Schizophr Bull 2022 Jun;48(4):893-901

Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Background And Hypothesis: Quantitative models of psychopathology can empirically guide subclassification of heterogeneous clinical presentations such as psychosis; they are particularly well-equipped to capture the nuanced symptomatology observed in first-episode psychosis. As well, components may be better aligned with biological variables. The current study sought to confirm and extend knowledge of the hierarchical structure of psychosis symptoms in first-episode psychosis. Read More

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Delusions of a Magic Man Shared by Codependent Twin Sisters.

Case Rep Psychiatry 2022 13;2022:9126521. Epub 2022 May 13.

Department of Psychiatry, St. John's Episcopal Hospital, 327 Beach 19th street, Far Rockaway, NY 11691, USA.

Folie à deux has been called double insanity or shared psychotic disorder. In this report, we describe the case of twin sisters who presented with identical delusions. Both sisters reported a "magic man" lived in their bodies and made them weak. Read More

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Anti-saccade as a Tool to Evaluate Neurocognitive Impairment in Alcohol Use Disorder.

Front Psychiatry 2022 27;13:823848. Epub 2022 Apr 27.

Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

It has been widely shown that chronic alcohol use leads to cognitive dysfunctions, especially inhibitory control. In an extension of the traditional approach, this research field has benefited from the emergence of innovative measures, among which is an anti-saccade, allowing direct and sensitive measure of the eye movements indexing attention bias to alcohol-related cues and the capability of inhibiting the reflexive saccades to the cues. During the past decade, there are numerous reports showing that drinkers make more unwanted reflexive saccades and longer latency in the anti-saccade task. Read More

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The Autism-Psychosis Continuum Conundrum: Exploring the Role of the Endocannabinoid System.

Int J Environ Res Public Health 2022 05 5;19(9). Epub 2022 May 5.

Unit of Psychiatry, Department of Medicine (DAME), University of Udine, 33100 Udine, Italy.

Evidence indicates shared physiopathological mechanisms between autism and psychosis. In this regard, the endocannabinoid system has been suggested to modulate neural circuits during the early stage of neurodevelopment, with implications for both autism and psychosis. Nevertheless, such potential common markers of disease have been investigated in both autism and psychosis spectrum disorders, without considering the conundrum of differentiating the two groups of conditions in terms of diagnosis and treatment. Read More

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Shared Psychotic Disorder in Old Age: Syndrome of Folie à Deux.

Case Rep Psychiatry 2022 2;2022:8811140. Epub 2022 May 2.

Department of Geriatric Psychiatry, Geneva University Hospitals, Switzerland.

Background: Shared psychotic disorder is a relatively rare condition first described by Lasegue and Falret in 1877, who named the syndrome "folie à deux" (FAD). This disorder is characterized by the transference of delusional ideas from one individual to another.

Methods: We report the case of a mother and daughter who exhibited shared delusions of persecution after living in near-total isolation for 10 years. Read More

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A Clinical and Psychopathological Approach to Radicalization Among Adolescents.

Front Psychiatry 2022 25;13:788154. Epub 2022 Apr 25.

Service de Psychiatrie de l'Enfant et de l'Adolescent, Hôpital Pitié-Salpêtrière, APHP.SU, Paris, France.

Recent studies have shown higher rates of radicalization of adolescents than in the 2000s. Since 2015, radicalization prevention units have been implemented in child and adolescent psychiatry departments in France. We aimed to report on the psychopathology of adolescents who were followed up in a university department due to their "radical conduct. Read More

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Commentary: Diagnostic Challenges.

Amir Garakani

J Psychiatr Pract 2022 05 1;28(3):270-271. Epub 2022 May 1.

GARAKANI: Department of Psychiatry and Behavioral Health, Greenwich Hospital, Greenwich, CT; Department of Psychiatry, Yale University School of Medicine, New Haven, CT.

The 3 cases presented in this issue highlight diagnostic challenges in evaluating and treating patients with complicated presentations. The first case involved a man with mild neurocognitive disorder due to Alzheimer disease accompanied by depressive and anxiety symptoms and what appeared to be previously undiagnosed attention-deficit/hyperactivity disorder. The second case involved an unusual case of shared psychotic disorder involving a woman with a primary diagnosis of bipolar disorder and her husband with posttraumatic stress disorder. Read More

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Shared Psychotic Disorder Associated With Bipolar Disorder in the Primary Case in the Context of Opioid Misuse.

J Psychiatr Pract 2022 05 1;28(3):259-264. Epub 2022 May 1.

Bipolar disorder (BD) is a serious chronic mood disorder associated with high rates of co-occurring substance use disorders. Shared psychotic disorder (SPD) is a rare clinical phenomenon and has been reported in only a few cases of individuals diagnosed with BD. Furthermore, reports concerning SPD being induced by substance use or withdrawal are lacking. Read More

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Folie à Deux in the Setting of COVID-19 Quarantine.

Case Rep Psychiatry 2022 20;2022:2046436. Epub 2022 Apr 20.

Bergen Newbridge Medical Center, Department of Psychiatry, Paramus, NJ, USA.

We relay the case of a middle-aged male and his mother, an elderly female, who presented with in the context of shared delusions of persecution and somatization during the COVID-19 quarantine period. The delusions were described as electric microwave shocks being transmitted to their internal organs by neighbors, followed by somatic symptoms of palpitations, headaches, and a shock-like perception. To the best of our knowledge, there have not been any reports that describe the development of in the setting of the COVID-19 quarantine. Read More

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Immuno-metabolic profile of patients with psychotic disorders and metabolic syndrome. Results from the FACE-SZ cohort.

Brain Behav Immun Health 2022 Jul 29;22:100436. Epub 2022 Mar 29.

Univ Paris Est Créteil, INSERM U955, IMRB, Translational NeuroPsychiatry Laboratory, F-94010, Créteil, France.

Background: Metabolic syndrome (MetS) is a highly prevalent and harmful medical disorder often comorbid with psychosis where it can contribute to cardiovascular complications. As immune dysfunction is a key shared component of both MetS and schizophrenia (SZ), this study investigated the relationship between immune alterations and MetS in patients with SZ, whilst controlling the impact of confounding clinical characteristics including psychiatric symptoms and comorbidities, history of childhood maltreatment and psychotropic treatments.

Method: A total of 310 patients meeting DSM-IV criteria for SZ or schizoaffective disorders (SZA), with or without MetS, were systematically assessed and included in the FondaMental Advanced Centers of Expertise for Schizophrenia (FACE-SZ) cohort. Read More

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Growth charts of brain morphometry for preschool children.

Neuroimage 2022 07 14;255:119178. Epub 2022 Apr 14.

Laboratory of Psychological Health and Imaging, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Key laboratory of Psychotic disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Brain Science and Technology Research Center, Shanghai Jiao Tong University, Shanghai, China; Institute of Psychological and Behavioral Sciences, Shanghai Jiao Tong University, Shanghai, China. Electronic address:

Brain development from 1 to 6 years of age anchors a wide range of functional capabilities and carries early signs of neurodevelopmental disorders. However, quantitative models for depicting brain morphology changes and making individualized inferences are lacking, preventing the identification of early brain atypicality during this period. With a sample size of 285, we characterized the age dependence of the cortical thickness and subcortical volume in neurologically normal children and constructed quantitative growth charts of all brain regions for preschool children. Read More

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Folie à Deux During Self-Quarantine in the COVID-19 Pandemic: a Case Report.

T Kawasaki

East Asian Arch Psychiatry 2022 Mar;32(1):22-23

Miyazato Hospital, Nago, Okinawa, Japan.

Folie à deux is also known as psychosis of association or shared paranoid disorder. We describe a mother and her two daughters who experienced shared delusions and hallucinations during self-quarantine in COVID-19 pandemic. The mother was later diagnosed with schizophrenia and prescribed brexpiprazole, whereas her two daughters were diagnosed with psychosis of association affected by their mother. Read More

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Different patterns of white matter microstructural alterations between psychotic and non-psychotic bipolar disorder.

PLoS One 2022 18;17(3):e0265671. Epub 2022 Mar 18.

Department of Psychiatry, Chonnam National University Medical School, Gwangju, Republic of Korea.

This study aimed to investigate alterations in white matter (WM) microstructure in patients with psychotic and non-psychotic bipolar disorder (PBD and NPBD, respectively). We used 3T-magnetic resonance imaging to examine 29 PBD, 23 NPBD, and 65 healthy control (HC) subjects. Using tract-based spatial statistics for diffusion tensor imaging data, we compared fractional anisotropy (FA) and mean diffusion (MD) pairwise among the PBD, NPBD, and HC groups. Read More

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Experiences of shared decision making among patients with psychotic disorders in Norway: a qualitative study.

BMC Psychiatry 2022 03 17;22(1):192. Epub 2022 Mar 17.

Norwegian National Advisory Unit on Concurrent Substance Abuse and Mental Health Disorders, Innlandet Hospital Trust, P.B 104, 2381, Brumunddal, Norway.

Background: Shared decision making (SDM) is a process where the patient and the health professional collaborate to make decisions based on both the patient's preferences and the best available evidence. Patients with psychotic disorders are less involved in making decisions than they would like. More knowledge of these patients' experiences of SDM may improve implementation. Read More

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Structural connectivity associated with familial risk for mental illness: A meta-analysis of diffusion tensor imaging studies in relatives of patients with severe mental disorders.

Hum Brain Mapp 2022 06 14;43(9):2936-2950. Epub 2022 Mar 14.

Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.

Schizophrenia (SCZ), bipolar disorder (BD), and major depressive disorder (MDD) are heritable conditions with overlapping genetic liability. Transdiagnostic and disorder-specific brain changes associated with familial risk for developing these disorders remain poorly understood. We carried out a meta-analysis of diffusion tensor imaging (DTI) studies to investigate white matter microstructure abnormalities in relatives that might correspond to shared and discrete biomarkers of familial risk for psychotic or mood disorders. Read More

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Genome-wide identification of the shared genetic basis of cannabis and cigarette smoking and schizophrenia implicates NCAM1 and neuronal abnormality.

Psychiatry Res 2022 04 17;310:114453. Epub 2022 Feb 17.

Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China; Shanghai Key Laboratory of Psychotic Disorders, Shanghai, China; CAS Center for Excellence in Brain Science and Intelligence Technology (CEBSIT), Chinese Academy of Sciences, Shanghai, China. Electronic address:

Objectives: Confirming the existence and composition of the shared genetic basis of Schizophrenia and cannabis and cigarette smoking has critical values for the clinical prevention and intervention of psychosis.

Methods: To achieve this goal, we leveraged Genome-Wide summary statistics of Schizophrenia (n = 99,934), cigarette smoking (n = 518,633) and cannabis usage (n = 162,082). We applied Causal Analysis Using Summary Effect Estimates (CAUSE) and genomic structural equation modeling (GenomicSEM) to quantify the contribution of a common genetic factor of cannabis and cigarette smoking and schizophrenia (referred to as SCZ_SMO), then identified genome-wide loci that made up SCZ_SMO. Read More

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The Role of Attitudes Toward Medication and Treatment Adherence in the Clinical Response to LAIs: Findings From the STAR Network Depot Study.

Front Psychiatry 2021 16;12:784366. Epub 2021 Dec 16.

World Health Organization (WHO) Collaborating Centre for Research and Training in Mental Health and Service Evaluation, Department of Neuroscience, Biomedicine and Movement Sciences, Section of Psychiatry, University of Verona, Verona, Italy.

Long-acting injectable (LAI) antipsychotics are efficacious in managing psychotic symptoms in people affected by severe mental disorders, such as schizophrenia and bipolar disorder. The present study aimed to investigate whether attitude toward treatment and treatment adherence represent predictors of symptoms changes over time. The STAR Network "Depot Study" was a naturalistic, multicenter, observational, prospective study that enrolled people initiating a LAI without restrictions on diagnosis, clinical severity or setting. Read More

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December 2021

Partial Agonists and Dual Disorders: Focus on Dual Schizophrenia.

Front Psychiatry 2021 16;12:769623. Epub 2021 Dec 16.

Hospital Universitario Gregorio Marañon, Madrid, Spain.

Dual disorder is a term applied to patients with an addictive disorder and other mental disorder. Epidemiological studies have established that dual disorders are an expectation rather than an exception. They are difficult to diagnose and treat and constitute a huge burden for both patients and their relatives and society. Read More

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December 2021

Familial clustering of psychiatric disorders and low IQ.

Psychol Med 2021 Dec 16:1-7. Epub 2021 Dec 16.

Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Background: Although the ICD and DSM differentiate between different psychiatric disorders, these often share symptoms, risk factors, and treatments. This was a population-based, case-control, sibling study examining familial clustering of all psychiatric disorders and low IQ, using data from the Israel Draft-Board Registry on all Jewish adolescents assessed between 1998 and 2014.

Methods: We identified all cases with autism spectrum disorder (ASD, N = 2128), severe intellectual disability (ID, N = 9572), attention-deficit hyperactive disorder (ADHD) (N = 3272), psychotic (N = 7902), mood (N = 9704), anxiety (N = 10 606), personality (N = 24 816), or substance/alcohol abuse (N = 791) disorders, and low IQ (⩾2 SDs below the population mean, N = 31 186). Read More

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December 2021

Structural covariance networks in schizophrenia: A systematic review Part I.

Schizophr Res 2022 02 11;240:1-21. Epub 2021 Dec 11.

Department of Statistics, University of Pittsburgh, 1826 Wesley W. Posvar Hall, Pittsburgh, PA 15260, United States of America.

Background: Schizophrenia is proposed as a disorder of dysconnectivity. However, examination of complexities of dysconnectivity has been challenging. Structural covariance networks (SCN) provide important insights into the nature of dysconnectivity. Read More

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February 2022

Family History of Psychiatric Disorders and Clinical Factors Associated With a Schizophrenia Diagnosis.

Inquiry 2021 Jan-Dec;58:469580211060797

Medical Doctor, Hospitalization Services, 428841Psychiatric Hospital Fray Bernardino Álvarez, Mexico City, Mexico.

Background: Schizophrenia (SCH) and bipolar disorder (BD) have both shared and unique genetic risk factors and clinical characteristics. The aim of the present study was to identify potential risk factors significantly associated with SCH, relative to a BD reference group.

Methods: Data were obtained from medical records of patients that entered a major Mexico City hospital during 2009-2010 presenting psychotic symptoms (n = 1132; 830 cases of SCH, 302 cases of BD; 714 men and 418 women). Read More

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January 2022

The addiction risk factor: A unitary genetic vulnerability characterizes substance use disorders and their associations with common correlates.

Neuropsychopharmacology 2021 Nov 8. Epub 2021 Nov 8.

Washington University School of Medicine, Department of Psychiatry, Saint Louis, MO, USA.

Substance use disorders commonly co-occur with one another and with other psychiatric disorders. They share common features including high impulsivity, negative affect, and lower executive function. We tested whether a common genetic factor undergirds liability to problematic alcohol use (PAU), problematic tobacco use (PTU), cannabis use disorder (CUD), and opioid use disorder (OUD) by applying genomic structural equation modeling to genome-wide association study summary statistics for individuals of European ancestry (Total N = 1,019,521; substance-specific Ns range: 82,707-435,563) while adjusting for the genetics of substance use (Ns = 184,765-632,802). Read More

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November 2021

Common and differential connectivity profiles of deep brain stimulation and capsulotomy in refractory obsessive-compulsive disorder.

Mol Psychiatry 2022 Feb 26;27(2):1020-1030. Epub 2021 Oct 26.

School of Psychological and Cognitive Sciences; Beijing Key Laboratory of Behavior and Mental Health; IDG/McGovern Institute for Brain Research; Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China.

Neurosurgical interventions including deep brain stimulation (DBS) and capsulotomy have been demonstrated effective for refractory obsessive-compulsive disorder (OCD), although treatment-shared/-specific network mechanisms remain largely unclear. We retrospectively analyzed resting-state fMRI data from three cohorts: a cross-sectional dataset of 186 subjects (104 OCD and 82 healthy controls), and two longitudinal datasets of refractory patients receiving ventral capsule/ventral striatum DBS (14 OCD) and anterior capsulotomy (27 OCD). We developed a machine learning model predictive of OCD symptoms (indexed by the Yale-Brown Obsessive Compulsive Scale, Y-BOCS) based on functional connectivity profiles and used graphic measures of network communication to characterize treatment-induced profile changes. Read More

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February 2022

Impact of Comorbid Alcohol Use Disorder on Health-Related Quality of Life Among Patients With Depressive Symptoms.

Front Psychiatry 2021 8;12:688136. Epub 2021 Oct 8.

Department of Psychiatry, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.

In psychiatric clinical practice, comorbidity of depression and alcohol use disorder (AUD) is common. Both disorders have a negative impact on health-related quality of life (HRQoL) in general population. However, research on the impact of comorbid AUD on HRQoL among clinically depressed patients is limited. Read More

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October 2021

The roots of paternal depression: Experienced and nonexperienced trauma or Folie a Deux?

Dev Psychobiol 2021 11;63(7):e22197

Department of Psychology and the Gonda Brain Research Center, Bar Ilan University, Ramat Gan, Israel.

The transition to fatherhood may be challenged with anxiety and trepidation. A high prevalence has been found for paternal depression and it is reactive to maternal depression. This review aims to address potential sources of paternal depression, which may have adverse consequences on child development. Read More

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November 2021

Folie a Deux: Shared Psychotic Disorder in a Medical Unit.

Case Rep Psychiatry 2021 25;2021:5520101. Epub 2021 Sep 25.

Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY 11549, USA.

Introduction: A shared psychotic disorder is a system of delusions shared by two or more individuals. Shared psychotic disorders typically develop in pairs or groups with a close relationship who are socially isolated. The function and affect of those inflicted with shared psychotic disorders usually remain intact. Read More

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September 2021

Shared Decision Making With Young People at Ultra High Risk of Psychotic Disorder.

Front Psychiatry 2021 16;12:683775. Epub 2021 Sep 16.

North East London Foundation NHS Trust, London, United Kingdom.

While the majority of young people who meet the criteria for being considered at increased risk of psychosis do not go on to develop a psychotic disorder, young people are currently being identified and treated in early intervention services. Ethical concerns have been raised concerning the decision about whether or not to provide treatment, and if so, what type of treatment. This study sought to support young people themselves to make these decisions with support from their clinician through a shared decision-making approach, facilitated by an online decision aid. Read More

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September 2021

Shared decision making in a semi-secluded chronic psychiatric ward: The reflective lifeworld experiences of patients with schizophrenia or schizoaffective disorders and nursing staff.

Arch Psychiatr Nurs 2021 10 12;35(5):519-525. Epub 2021 Jul 12.

Dimence Group, Center for Mental Health Care, SCBS Bipolar Disorders, Deventer, the Netherlands; Saxion University of Applied Sciences, Deventer, the Netherlands. Electronic address:

Background: Shared decision making (SDM) enhances recovery-oriented mental healthcare, but literature predominately focuses on doctor-patient collaboration leaving the role of mental health nurses (MHN's) underexposed.

Aim: This study describes the experiences of patients with schizophrenia or schizoaffective disorder with SDM in a semi-secluded psychiatric facility, and the attitudes toward SDM by MHN's.

Method: A hermeneutic phenomenological design. Read More

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October 2021