119,811 results match your criteria Shared Psychotic Disorder


What's going on at the entrance? A characterisation of the social interface in ant nests.

Behav Processes 2018 Dec 8. Epub 2018 Dec 8.

Unit of Social Ecology, Université libre de Bruxelles, CP231, Bd du Triomphe, 1050, Brussels, Belgium.

Nest entrances are key locations where information about environmental opportunities and constraints are shared between foragers and inner-nest workers. However, despite its functional value, we still lack a detailed characterisation of the interface between the nest and the environment. Here, we identified the social interface in the ant Myrmica rubra as being the population of ants that faced the nest entrance and that received significantly more contacts from returning foragers than other nearby ants. Read More

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December 2018
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Hla in colombia wayu from guajira peninsula amerindians: pacific ocean relationships.

Hum Immunol 2018 Dec 8. Epub 2018 Dec 8.

Departmentof Medicina, Ciencias de la Salud, Universidad del Norte, Barranquilla, Colombia.

Wayu Amerindians live around Guajira Peninsula shared by Colombia and Venezuela. Wayu from Colombia South have been studied for their HLA profile and these data put in context with both genetic and cultural relatedness to Pacific Islanders. HLA-A*24 and HLA-B*35 (most likely HLA-A*24:02 and HLA-B*35:05) and HLA-DRB1*04:03 and HLA-DQB1*03:02 are shared both by Wayu and other Amerindians and Pacific Islanders in specific high frequency. Read More

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December 2018

Hospital pharmacy technicians practice and perceptions in France and Quebec, Canada.

Int J Pharm Pract 2018 Dec 11. Epub 2018 Dec 11.

Unité de Recherche en Pratique Pharmaceutique, CHU Sainte-Justine, Montréal, QC, Canada.

Objectives: To describe practice and perceptions of hospital pharmacy technicians (HPTs) in France and in Quebec, Canada. The secondary objective was to compare both work settings to identify differences.

Methods: Cross-sectional online survey in December 2016 and February 2017. Read More

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December 2018

The role of sleeping sites in the predator-prey dynamics of leopards and olive baboons.

Am J Primatol 2018 Dec;80(12):e22932

Department of Anthropology, University of California, Davis, California.

Predation is widely recognized as an important selective pressure on prey animals such as baboons (Papio spp.), which face high leopard (Panthera pardus) predation risk, particularly at night. Baboons regularly sleep on cliff faces and in trees at night, ostensibly to avoid such predators. Read More

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December 2018

Trust, Money, and Power: Life Cycle Dynamics in Alliances Between Management Partners and Accountable Care Organizations.

Milbank Q 2018 Dec;96(4):755-781

Gillings School of Public Health, University of North Carolina at Chapel Hill.

Policy Points Accountable care organizations (ACOs) form alliances with management partners to access financial, technical, and managerial support. Alliances between ACOs and management partners are subject to destabilizing tension around decision-making authority, distribution of shared savings, and conflicting goals and values. Management partners may serve either as trainers, ultimately breaking off from the ACO, or as central drivers of the ACO. Read More

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December 2018

Extreme adaptation in caves.

Anat Rec (Hoboken) 2018 Dec 11. Epub 2018 Dec 11.

Department of Biological Sciences, The University of Alabama in Huntsville, 301 Sparkman Drive, Huntsville, AL 35899.

Cave adaptation leads to unique anatomical specializations in many taxonomic groups. As the role of vision is reduced or disappears in a subterranean environment, other specializations arise to allow the organism to successfully detect and interact with their environment. A suite of unique, convergent phenotypes associated with subterranean adaptation has emerged (termed troglomorphy), with reduction or loss of pigmentation and eyes being the most conspicuous. Read More

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December 2018

Talking about trauma in therapy: Perspectives from young people with post-traumatic stress symptoms and first episode psychosis.

Early Interv Psychiatry 2018 Dec 9. Epub 2018 Dec 9.

Orygen, The National Centre of Excellence in Youth Mental Health, Parkville, Victoria, Australia.

Aim: Despite recommendations from national guidelines, individuals with first episode psychosis (FEP) are currently unlikely to have the effects of their traumatic experiences assessed and treated within psychosis treatment. This may be due to the mismatch between the objectives of trauma-specific treatments (directly targeting post-traumatic stress symptoms by talking about the trauma) and trauma-informed care (limiting practices that may retraumatise clients). We aimed to gain an understanding of what it was like for young people to talk about trauma in FEP treatment, and how their experiences related to the broad conceptualisations of trauma-informed and trauma-specific treatment approaches. Read More

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December 2018

The Nomological Network of a Behavioral Distress Tolerance Task in Veterans.

J Trauma Stress 2018 Dec 11. Epub 2018 Dec 11.

Department of Psychiatry, Virginia Commonwealth University, Richmond, Virginia, USA.

There is a relative lack of research on distress tolerance (DT) in veteran samples. The aims of the study were to (a) evaluate convergent and discriminant validity of a behavioral measure of DT compared to theoretically similar (i.e. Read More

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December 2018

Biological links in periodontitis and rheumatoid arthritis: Discovery via text-mining PubMed abstracts.

J Periodontal Res 2018 Dec 10. Epub 2018 Dec 10.

Faculty of Dentistry, The University of Hong Kong, Sai Yin Pun, Hong Kong.

Background And Objective: Primary research concerning molecular pathways that link rheumatoid arthritis with periodontitis is limited. Biomedical literature data mining can offer insights into putative linkage mechanisms toward hypothesis development, based on information discovery. The aim of this study was to explore potential Periodontitis-Rheumatoid Arthritis biological links by analysing "overlapping" genes reported in biomedical abstracts. Read More

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December 2018

Infants who die in shared sleeping situations differ from those who die while sleeping alone.

Acta Paediatr 2018 Dec 10. Epub 2018 Dec 10.

Discipline of Anatomy and Pathology, Adelaide Medical School, The University of Adelaide, Adelaide, Australia.

Aim: To determine whether there are differences between infants who are sharing a sleeping surface with others, compared to those who die alone.

Methods: A literature review was undertaken of pubmed and google scholar databases using search terms: sudden infant death syndrome, SIDS, cosleeping and overlaying.

Results: Statistically significant differences were found between the two groups in the sex ratios, and in staining of brain sections for β-amyloid precursor protein (β-APP), glial fibrillary acidic protein (GFAP) and terminal deoxynucleotidyl transferase-mediated dUTP nick-end labelling (TUNEL). Read More

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December 2018

Insulin-like peptides of the legume pod borer, Maruca vitrata, and their mediation effects on hemolymph trehalose level, larval development, and adult reproduction.

Arch Insect Biochem Physiol 2018 Dec 10:e21524. Epub 2018 Dec 10.

Department of Plant Medicals, Andong National University, Andong, Korea.

Insulin-like peptides (ILPs) of insects mediate various physiological processes including hemolymph sugar level, immature growth, female reproduction, and lifespan. In target cells of ILPs, insulin/insulin-like growth factor signaling (IIS) is highly conserved in animals. IIS in the legume pod borer, Maruca vitrata (Lepidoptera: Crambidae), is known to be involved in maintaining hemolymph trehalose levels and promoting larval growth. Read More

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December 2018

Identification of Key Genes and Pathways in Diabetic Nephropathy by Bioinformatics Analysis.

J Diabetes Investig 2018 Dec 9. Epub 2018 Dec 9.

Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Chinese PLA Medical School, 28 Fuxing Road, Beijing, 100853, China.

Aims: The aim of the study is to identify candidate differentially expressed genes (DEGs) and pathways using bioinformatics analysis and improve our understanding of the cause and potential molecular events of diabetic nephropathy (DN).

Materials And Methods: Two cohort profile datasets (GSE30528 and GSE33744) were integrated and used for deep analysis. We sorted DEGs and analyzed differential pathway enrichment. Read More

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December 2018

The Nature of the Shared Environment.

Behav Genet 2018 Dec 8. Epub 2018 Dec 8.

Center for Primary Health Care Research, Lund University, Malmö, Sweden.

While a standard part of twin modeling, the magnitude of shared environment (c) is rarely examined by comparing estimates obtained using other methods. To clarify these effects on familial resemblance, we estimated c for 20 diverse phenotypes in: (i) monozygotic and dizygotic twins, (ii) all step-siblings, and (iii) reared together and apart half-siblings, ascertained from the Swedish general population. The mean c estimates (± 95% CIs) differed across methods and were higher from twins (0. Read More

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December 2018

The contribution of parent-to-offspring transmission of telomeres to the heritability of telomere length in humans.

Hum Genet 2018 Dec 10. Epub 2018 Dec 10.

Department of Public Health Sciences, University of Chicago, Chicago, IL, 60615, USA.

Leukocyte telomere length (LTL) is a heritable trait with two potential sources of heritability (h): inherited variation in non-telomeric regions (e.g., SNPs that influence telomere maintenance) and variability in the lengths of telomeres in gametes that produce offspring zygotes (i. Read More

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December 2018

Social media for dissemination and public engagement in neurosurgery-the example of Brainbook.

Acta Neurochir (Wien) 2018 Dec 10. Epub 2018 Dec 10.

Department of Neurosurgery, The Royal London Hospital, London, UK.

Background: Public engagement has become one of the most effective tools in gaining feedback and perspectives from members of the public, involving patients with decisions, and inspiring young people to carry the medical profession forwards. Brainbook is a multi-platform, social media-based resource that was created specifically to enhance public engagement in neurosurgery and results from one of its case discussions will be reported in this paper.

Methods: A Brainbook case was created in collaboration with the NIHR Global Health Research Group on Neurotrauma and presented over 3 days (23-25 February 2018). Read More

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December 2018

"Do You Know What I Know?": How Communication Norms and Recipient Design Shape the Content and Effectiveness of Patient Handoffs.

J Gen Intern Med 2018 Dec 10. Epub 2018 Dec 10.

VA HSR&D Center for Health Information and Communication, Roudebush VAMC, Indianapolis, USA.

Background: Poor communication during end-of-shift transfers of care (handoffs) is associated with safety risks and patient harm. Despite the common perception that handoffs are largely a one-way transfer of information, researchers have documented that they are complex interactions, guided by implicit social norms and mental frameworks.

Objectives: We investigated communication strategies that resident physicians report deploying to tailor information during face-to-face handoffs that are often based on their implicit inferences about the perceived information needs and potential harm to patients. Read More

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December 2018

How Biomedical HIV Prevention Trials Incorporate Behavioral and Social Sciences Research: A Typology of Approaches.

AIDS Behav 2018 Dec 10. Epub 2018 Dec 10.

Department of Social Medicine, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.

In the field of biomedical HIV prevention, researchers have meaningfully incorporated behavioral and social sciences research (BSSR) into numerous clinical trials, though the timing and degree of integration have been highly variable. The literature offers few frameworks that systematically characterize these collaborations. To fill this gap, we developed a typology of BSSR approaches within biomedical HIV prevention research. Read More

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December 2018

Klebsiella pneumoniae causing urinary tract infections in companion animals and humans: population structure, antimicrobial resistance and virulence genes.

J Antimicrob Chemother 2018 Dec 10. Epub 2018 Dec 10.

CIISA - Center for Interdisciplinary Research in Animal Health, Faculty of Veterinary Medicine, University of Lisbon, Lisbon, Portugal.

Objectives: To characterize the population structure, antimicrobial resistance and virulence genes of Klebsiella spp. isolated from dogs, cats and humans with urinary tract infections (UTIs).

Methods: Klebsiella spp. Read More

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December 2018

A glossary of user-centered design strategies for implementation experts.

Transl Behav Med 2018 Dec 7. Epub 2018 Dec 7.

Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA.

User-centered design (UCD), a discipline that seeks to ground the design of an innovation in information about the people who will ultimately use that innovation, has great potential to improve the translation of evidence-based practices from behavioral medicine research for implementation in health care settings. UCD is a diverse, innovative field that remains highly variable in terms of language and approaches. Ultimately, we produced a glossary of UCD-related strategies specifically for experts in implementation research and practice, with the goal of promoting interdisciplinary collaboration in implementation efforts. Read More

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December 2018

Diversity and Phylogenetic Analyses Reveal Horizontal Transmission of Endosymbionts Between Whiteflies and Their Parasitoids.

J Econ Entomol 2018 Dec 10. Epub 2018 Dec 10.

Department of Entomology, Nanjing Agricultural University, Nanjing, China.

Endosymbionts are widely distributed among insects via intraspecific vertical transmission and interspecific horizontal transmission. Parasitoids have attracted considerable interest due to their possible role in the horizontal transmission of endosymbionts. Horizontal transmission of endosymbionts between whiteflies via parasitoids has been revealed in the laboratory. Read More

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December 2018

Sibling Recurrence Risk and Cross-aggregation of Attention-Deficit/Hyperactivity Disorder and Autism Spectrum Disorder.

JAMA Pediatr 2018 Dec 10. Epub 2018 Dec 10.

Department of Psychiatry, Oregon Health & Science University, Portland.

Importance: Attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) are believed to partially share genetic factors and biological influences. As the number of children with these diagnoses rises, so does the number of younger siblings at presumed risk for ADHD and ASD; reliable recurrence risk estimates within and across diagnoses may aid screening and early detection efforts and enhance understanding of potential shared causes.

Objective: To examine within-diagnosis sibling recurrence risk and sibling cross-aggregation of ADHD and ASD among later-born siblings of children with either disorder. Read More

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December 2018

Plastid genomes from diverse glaucophyte genera reveal a largely conserved gene content and limited architectural diversity.

Genome Biol Evol 2018 Dec 11. Epub 2018 Dec 11.

Department of Biology, University of New Brunswick, Canada.

Plastid genome (ptDNA) data of Glaucophyta has been limited for many years to the genus Cyanophora. Here we sequenced the ptDNAs of Gloeochaete wittrockiana, Cyanoptyche gloeocystis, Glaucocystis incrassata and Glaucocystis sp. BBH. Read More

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December 2018

Identifying the anti-inflammatory response to lipid lowering therapy. A Position Paper from the Working Group on Atherosclerosis and Vascular Biology of the European Society of Cardiology.

Cardiovasc Res 2018 Dec 6. Epub 2018 Dec 6.

Karolinska Institutet, Stockholm, Sweden.

Dysregulated lipid metabolism induces an inflammatory and immune response leading to atherosclerosis. Conversely, inflammation may alter lipid metabolism. Recent treatment strategies in secondary prevention of atherosclerosis support beneficial effects of both anti-inflammatory and lipid-lowering therapies beyond current targets. Read More

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December 2018

SURVEY ON DATA MANAGEMENT IN RADIATION PROTECTION RESEARCH.

Radiat Prot Dosimetry 2018 Dec 11. Epub 2018 Dec 11.

Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge, United Kingdom.

The importance of datasharing is of increasing concern to funding bodies and institutions. With some prescience, the radiobiology community has established datasharing infrastructures over the last two decades, including STORE; however, the utilization of these databases is disappointing. The aim of the present study was to identify the current state of datasharing amongst researchers in radiation protection, and to identify barriers to effective sharing. Read More

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December 2018

The NOTCH Pathway and Its Mutations in Mature B Cell Malignancies.

Front Oncol 2018 26;8:550. Epub 2018 Nov 26.

Italian Institute for Genomic Medicine, Turin, Italy.

The systematic application of next-generation sequencing to large cohorts of oncologic samples has opened a Pandora's box full of known and novel genetic lesions implicated in different steps of cancer development and progression. Narrowing down to B cell malignancies, many previously unrecognized genes emerged as recurrently mutated. The challenge now is to determine how the mutation in a given gene affects the biology of the disease, paving the way to functional genomics studies. Read More

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November 2018

Multi-disciplinary and shared decision-making approach in the management of organ-confined prostate cancer.

Arab J Urol 2018 Dec 6;16(4):367-377. Epub 2018 Aug 6.

Department of Urology, Aga Khan University, Karachi, Pakistan.

Decision-making in the management of organ-confined prostate cancer is complex as it is based on multi-factorial considerations. It is complicated by a multitude of issues, which are related to the patient, treatment, disease, availability of equipment(s), expertise, and physicians. Combination of all these factors play a major role in the decision-making process and provide for an interactive decision-making preferably in the multi-disciplinary team (MDT) meeting. Read More

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December 2018
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Conserved Composition of Nod Factors and Exopolysaccharides Produced by Different Phylogenetic Lineage Strains Nodulating Soybean.

Front Microbiol 2018 26;9:2852. Epub 2018 Nov 26.

Laboratoire des IMRCP, UMR5623 Université Paul Sabatier, CNRS, Toulouse, France.

The structural variation of symbiotic signals released by rhizobia determines the specificity of their interaction with legume plants. Previous studies showed that strains from different phylogenetic lineages had different symbiotic performance on certain cultivated soybeans. Whether they released similar or different symbiotic signals remained unclear. Read More

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November 2018

Whole-Genome Sequence of Sphingomonas sp. Strain FARSPH, a Novel Sf9 Insect Cell Culture Contaminant.

Microbiol Resour Announc 2018 Nov 1;7(17). Epub 2018 Nov 1.

Laboratorios de Investigación y Desarrollo, FARVET, Chincha Alta, Ica, Peru.

Here, we report the whole-genome sequence of Sphingomonas sp. strain FARSPH, isolated from an insect cell line as a contaminant. FARSPH shared high identity with Sphingomonas melonis and Sphingomonas aquatilis strains. Read More

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November 2018

Interactive calculator for operating characteristics of phase I cancer clinical trials using standard 3+3 designs.

Contemp Clin Trials Commun 2018 Dec 7;12:145-153. Epub 2018 Nov 7.

Department of Biostatistics and Bioinformatics, Emory University, Atlanta, GA, United States.

Among various Phase I clinical trial designs, rule-based standard 3 + 3 designs are the most widely utilized for their simplicity and robustness. It is necessary to define crucial operating characteristics of a Phase I clinical trial before it starts. Based on the assumed probability of dose limiting toxicity (DLT) at each tested dose level, Lin and Shih elaborated formulas to calculate the five key operating characteristics of Phase I clinical trials using the two subtypes of standard 3 + 3 designs (with vs without dose de-escalation): probability of each dose level being chosen as the maximum tolerated dose (MTD); expected number of patients treated at each dose level; expected number of patients experiencing DLT at each dose level; target toxicity level (TTL) (expected probability of DLT at MTD); expected total number of patients experiencing DLT. Read More

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December 2018

Three May Be Better Than Two: A Proposal for Metformin Addition to PI3K/Akt Inhibitor-antiandrogen Combination in Castration-resistant Prostate Cancer.

Cureus 2018 Oct 2;10(10):e3403. Epub 2018 Oct 2.

Endocrinology, Colonel Chaabani Hospital, El Menia, DZA.

Prostate cancer is a prevalent malignant disease. Castration-resistant prostate cancer (CRPC) is a poor prognosis form that develops upon resistance to first-line androgen deprivation therapy. Intensive research is ongoing to find efficient therapeutics for this refractory state. Read More

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October 2018

Analyses of long non-coding RNA and mRNA profiling in the spleen of diarrheic piglets caused by type C.

PeerJ 2018 30;6:e5997. Epub 2018 Nov 30.

College of Animal Science and Technology, Gansu Agricultural University, Lanzhou, Gansu, China.

Background: () type C is the most common bacteria causing piglet diarrheal disease and it greatly affects the economy of the global pig industry. The spleen is an important immune organ in mammals; it plays an irreplaceable role in resisting and eradicating pathogenic microorganisms. Based on different immune capacity in piglets, individuals display the resistance and susceptibility to diarrhea caused by type C. Read More

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November 2018

GoFish: A versatile nested PCR strategy for environmental DNA assays for marine vertebrates.

PLoS One 2018 11;13(12):e0198717. Epub 2018 Dec 11.

Laboratory of Genetically Encoded Small Molecules, The Rockefeller University, New York, NY, United States of America.

Here we describe GoFish, a strategy for single-species environmental DNA (eDNA) presence/absence assays using nested PCR. The assays amplify a mitochondrial 12S rDNA segment with vertebrate metabarcoding primers, followed by nested PCR with M13-tailed, species-specific primers. Sanger sequencing confirms positives detected by gel electrophoresis. Read More

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December 2018

Epstein-Barr virus infection and variants of Epstein-Barr nuclear antigen-1 in synovial tissues of rheumatoid arthritis.

PLoS One 2018 11;13(12):e0208957. Epub 2018 Dec 11.

Department of Internal Medicine, Toho University Graduate School of Medicine, Tokyo, Japan.

Objective: The objective of the present study was to investigate Epstein-Barr virus (EBV) infection as an environmental factor for the development of rheumatoid arthritis (RA).

Methods: Synovial tissues were collected during surgery from 128 RA and 98 osteoarthritis (OA) patients. DNA was extracted from synovial tissues. Read More

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December 2018

Novel cancer therapies and their association with diabetes.

J Mol Endocrinol 2019 Feb;62(2):R187-R199

Division of Endocrinology, Metabolism and Nutrition, Duke University School of Medicine, Durham, North Carolina, USA.

Over the last decade, there has been a shift in the focus of cancer therapy from conventional cytotoxic drugs to therapies more specifically directed to cancer cells. These novel therapies include immunotherapy, targeted therapy and precision medicine, each developed in great part with a goal of limiting collateral destruction of normal tissues, while enhancing tumor destruction. Although this approach is sound in theory, even new, specific therapies have some undesirable, 'off target effects', in great part due to molecular pathways shared by neoplastic and normal cells. Read More

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February 2019

Patient-Reported Outcomes Over 5 Years After Whole- or Partial-Breast Radiotherapy: Longitudinal Analysis of the IMPORT LOW (CRUK/06/003) Phase III Randomized Controlled Trial.

J Clin Oncol 2018 Dec 11:JCO1800982. Epub 2018 Dec 11.

Indrani S. Bhattacharya, Joanne S. Haviland, Anna M. Kirby, Penelope Hopwood, John R. Yarnold, and Judith M. Bliss, The Institute of Cancer Research; Anna M. Kirby, Royal Marsden National Health Service Foundation Trust, London; Cliona C. Kirwan, University of Manchester and University Hospital of South Manchester, Manchester; and Charlotte E. Coles, Cambridge University, Cambridge, United Kingdom.

Purpose: IMPORT LOW demonstrated noninferiority of partial-breast and reduced-dose radiotherapy versus whole-breast radiotherapy for local relapse and similar or reduced toxicity at 5 years. Comprehensive patient-reported outcome measures collected at serial time points are now reported.

Patients And Methods: IMPORT LOW recruited women with low-risk breast cancer after breast-conserving surgery. Read More

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December 2018

Shared Adversity Increases Team Creativity Through Fostering Supportive Interaction.

Front Psychol 2018 23;9:2309. Epub 2018 Nov 23.

School of Psychology, University of Queensland, St Lucia, QLD, Australia.

In the current era, building more innovative teams is key to organizational success, yet there is little consensus on how best to achieve this. Common wisdom suggests that positive reinforcement through shared positive rewards builds social support within teams, and in turn facilitates innovation. Research on basic group processes, cultural rituals, and the evolution of pro-group behavior has, however, revealed that sharing adverse experiences is an alternative path to promoting group bonding. Read More

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November 2018

Comparison of gene expression in liver regeneration and hepatocellular carcinoma formation.

Cancer Manag Res 2018 15;10:5691-5708. Epub 2018 Nov 15.

College of Life Science, Henan Normal University, Xinxiang, Henan 453007, China,

Background: Liver -cell proliferation occurs in hepatocellular carcinoma (HCC) and liver regeneration (LR). The development and progression of HCC and LR have many similar molecular pathways with very different results. In simple terms, LR is a controllable process of organ recovery and function reconstruction, whereas liver cancer is uncontrollable. Read More

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November 2018

Perceptions of heart failure symptoms, disease severity, treatment decision-making, and side effects by patients and cardiologists: a multinational survey in a cardiology setting.

Ther Clin Risk Manag 2018 16;14:2265-2272. Epub 2018 Nov 16.

Real World Research, Adelphi Real World, Bollington, UK,

Purpose: Explore the extent to which heart failure (HF) symptoms and side effects of HF treatment experienced by patients are recognized by cardiologists, and concordance between patient-cardiologist perceptions of HF severity and patients' contributions to treatment decision-making.

Methods: A multinational, cross-sectional survey of cardiologists and patients with HF was conducted. Patient-record forms (PRFs) were completed by cardiologists for consecutive consulting patients with HF, who completed a patient self-completion questionnaire (PSC). Read More

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November 2018

Activation of ERK/CREB/BDNF pathway involved in abnormal behavior of neonatally Borna virus-infected rats.

Neuropsychiatr Dis Treat 2018 15;14:3121-3132. Epub 2018 Nov 15.

Department of Neurology, Yongchuan Hospital of Chongqing Medical University, Chongqing 402460, China,

Background: Neuropsychiatric disorders are devastating illnesses worldwide; however, the potential involvement of viruses in the pathophysiological mechanisms of psychiatric diseases have not been clearly elucidated. Borna disease virus (BDV) is a neurotropic, noncytopathic RNA virus.

Materials And Methods: In this study, we infected neonatal rats intracranially with BDV Hu-H1 and Strain V within 24 hours of birth. Read More

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November 2018

Identification and characterization of a novel infectious bursal disease virus from outbreaks in Maharashtra Province of India.

Vet World 2018 Nov 29;11(10):1516-1525. Epub 2018 Oct 29.

Department of Veterinary Microbiology, Nagpur Veterinary College, MAFSU, Nagpur - 440 006, Maharashtra, India.

Aim: The study was undertaken to isolate infectious bursal disease virus (IBDV) from clinical cases in broiler and cockerel flocks of Maharashtra state, India, and its molecular epidemiological investigation.

Materials And Methods: The morbid bursal tissues were collected from flocks suspected for IBD. The samples were subjected for virus adaptation in primary chicken embryo fibroblast (CEF) cells followed by confirmation by reverse transcription polymerase chain reaction (RT-PCR) for partial VP sequence and phylogenetic analysis. Read More

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November 2018

Distillation of the clinical algorithm improves prognosis by multi-task deep learning in high-risk Neuroblastoma.

PLoS One 2018 7;13(12):e0208924. Epub 2018 Dec 7.

Fondazione Bruno Kessler, Trento, Italy.

We introduce the CDRP (Concatenated Diagnostic-Relapse Prognostic) architecture for multi-task deep learning that incorporates a clinical algorithm, e.g., a risk stratification schema to improve prognostic profiling. Read More

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December 2018

Investigating the common set of acoustic parameters in sexual orientation groups: A voice averaging approach.

PLoS One 2018 10;13(12):e0208686. Epub 2018 Dec 10.

Department of Social, Environmental, and Economic Psychology, University of Koblenz-Landau, Landau, Germany.

While the perception of sexual orientation in voices often relies on stereotypes, it is unclear whether speech stereotypes and accurate perceptions of sexual orientation are each based on acoustic cues common to speakers of a given group. We ask if the stereotypical belief, that members of the same sexual orientation group share similar acoustic patterns, is accurate to some degree. To address this issue, we are the first to use a novel voice morphing technique to create voice averages from voices that represent extremes of a given sexual orientation group either in terms of actual or perceived sexual orientation. Read More

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December 2018

Rapamycin-inspired macrocycles with new target specificity.

Nat Chem 2018 Dec 10. Epub 2018 Dec 10.

Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA.

Rapamycin and FK506 are macrocyclic natural products with an extraordinary mode of action, in which they form binary complexes with FK506-binding protein (FKBP) through a shared FKBP-binding domain before forming ternary complexes with their respective targets, mechanistic target of rapamycin (mTOR) and calcineurin, respectively. Inspired by this, we sought to build a rapamycin-like macromolecule library to target new cellular proteins by replacing the effector domain of rapamycin with a combinatorial library of oligopeptides. We developed a robust macrocyclization method using ring-closing metathesis and synthesized a 45,000-compound library of hybrid macrocycles (named rapafucins) using optimized FKBP-binding domains. Read More

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December 2018

Immune genes are primed for robust transcription by proximal long noncoding RNAs located in nuclear compartments.

Nat Genet 2018 Dec 10. Epub 2018 Dec 10.

Gene Expression and Biophysics Group, Division of Chemical, Systems and Synthetic Biology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.

Accumulation of trimethylation of histone H3 at lysine 4 (H3K4me3) on immune-related gene promoters underlies robust transcription during trained immunity. However, the molecular basis for this remains unknown. Here we show three-dimensional chromatin topology enables immune genes to engage in chromosomal contacts with a subset of long noncoding RNAs (lncRNAs) we have defined as immune gene-priming lncRNAs (IPLs). Read More

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December 2018

Gene-gene and gene-environment interaction data for platinum-based chemotherapy in non-small cell lung cancer.

Sci Data 2018 Dec 11;5:180284. Epub 2018 Dec 11.

Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, P. R. China.

Gene-gene (GXG) and gene-environment (GXE) interactions play important roles in pharmacogenetics study. Simultaneously incorporating multiple single nucleotide polymorphisms (SNPs) and clinical factors is needed to explore the association of their interactions with drug response and toxicity phenotypes. We genotyped 504 SNPs in a total of 490 Chinese non-small cell lung cancer (NSCLC) patients, and the correlation of GXG and GXE interactions with platinum-based chemotherapeutic efficacy and safety were analyzed. Read More

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December 2018

Regulation of germ cell development by ARI1 family ubiquitin ligases in C. elegans.

Sci Rep 2018 Dec 10;8(1):17737. Epub 2018 Dec 10.

Department of Molecular Biology, College of Agriculture and Natural Resources, University of Wyoming, Laramie, WY, 82071, USA.

RING-between-RING (RBR) E3 ubiquitin ligases are implicated in various developmental processes, and mutations in genes encoding RBR proteins HHARI/ARIH1 and Parkin are associated with human diseases. Here we show by phylogenetic analysis that the ARI1 family has undergone a dramatic expansion within the Caenorhabditis clade in recent history, a characteristic shared by some genes involved in germline development. We then examined the effects of deleting all ARI1 family members in the nematode Caenorhabditis elegans, which to our knowledge represents the first complete knockout of ARI1 function in a metazoan. Read More

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December 2018

Evaluation of a Quality Improvement Intervention That Eliminated Routine Use of Opioids After Cesarean Delivery.

Obstet Gynecol 2018 Dec 4. Epub 2018 Dec 4.

Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Biology, the Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, and the Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, and the Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.

Objective: To evaluate the effects of eliminating the routine use of oral opioids for postcesarean delivery analgesia on postcesarean opioid consumption.

Methods: At a tertiary care center, we implemented a quality improvement intervention among faculty practice patients undergoing cesarean delivery, which consisted of 1) eliminating routine ordering of oral opioids after cesarean delivery, 2) implementing guidelines for ordering a short course of opioids when deemed necessary, and 3) coupling opioid prescribing at discharge to patterns of opioid use in-hospital combined with shared decision-making. All patients, both before and after the intervention, were administered neuraxial opioids and scheduled acetaminophen and nonsteroidal antiinflammatory medications in the absence of contraindications. Read More

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December 2018

An Exploratory, Descriptive Study of Nurse Leaders' Personal and Work Experiences During Union Negotiations and Strike Events.

J Nurs Adm 2019 Jan;49(1):42-47

Author Affiliations: Consultant Research & Professional Development (Dr Stichler), Center of Nursing Excellence Sharp HealthCare, San Diego, California, and Coeditor, HERD Journal, Thousand Oaks, California; Senior Specialist, Nursing (Mr Pelletier), Sharp Mesa Vista Hospital, San Diego, California; Adjunct Faculty (Mr Pelletier and Dr Thomason), University of San Diego Hahn School of Nursing and Health Science, California; Core Adjunct Faculty (Mr Pelletier), National University, San Diego, California; Clinical Nurse Specialist (Dr Thomason), Sharp Memorial Hospital, San Diego, California; Adjunct Faculty (Dr Thomason), Point Loma Nazarene University School of Nursing, San Diego, California.

Objective: This study explored the experiences, perceptions and emotional state of nurse leaders during union activities to understand the impact on their personal and professional lives.

Background: Other than anecdotal stories shared during union negotiations and strike preparations, very little evidence exists in nursing and healthcare literature about nursing unions and their impact on nurse leaders and their organizational priorities.

Methods: This study used an exploratory, descriptive design with a convenience and snowball sample of Association of California Nurse Leaders members. Read More

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January 2019

Pseudomyxoma Peritonei After a Total Pancreatectomy for Intraductal Papillary Mucinous Neoplasm With Colloid Carcinoma in Lynch Syndrome.

Pancreas 2019 Jan;48(1):135-138

Radiology, St Antonius Hospital, Nieuwegein, the Netherlands.

We report a case of pseudomyxoma peritonei (PMP) arising in a 62-year-old male patient with Lynch syndrome (LS). The patient's medical history included an adenocarcinoma of the colon for which a right hemicolectomy was performed and a pancreatectomy due to an intraductal papillary mucinous neoplasm (IPMN) with invasive colloid carcinoma. It was considered that the PMP could be a metastasis of the earlier colonic or pancreatic carcinoma. Read More

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January 2019

Association of polymorphisms with neuromyelitis optica spectrum disorders in Han Chinese patients.

Neural Regen Res 2019 Feb;14(2):346-353

Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.

Variants at the GTF2I repeat domain containing 1 (GTF2IRD1)-GTF2I locus are associated with primary Sjögren's syndrome, systemic lupus erythematosus, and rheumatoid arthritis. Numerous studies have indicated that this susceptibility locus is shared by multiple autoimmune diseases. However, until now there were no studies of the correlation between GTF2IRD1-GTF2I polymorphisms and neuromyelitis optica spectrum disorders (NMOSD). Read More

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February 2019