749 results match your criteria Shared Psychotic Disorder


A meta-review of literature reviews assessing the capacity of patients with severe mental disorders to make decisions about their healthcare.

BMC Psychiatry 2020 Jun 30;20(1):339. Epub 2020 Jun 30.

Department of Psychiatry, Parc Sanitari Sant Joan de Déu, Barcelona, Spain.

Background: Determining the mental capacity of psychiatric patients for making healthcare related decisions is crucial in clinical practice. This meta-review of review articles comprehensively examines the current evidence on the capacity of patients with a mental illness to make medical care decisions.

Methods: Systematic review of review articles following PRISMA recommendations. Read More

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http://dx.doi.org/10.1186/s12888-020-02756-0DOI Listing

Copy number variants in siblings of Mexican origin concordant for schizophrenia or bipolar disorder.

Psychiatry Res 2020 May 17;291:113018. Epub 2020 May 17.

Laboratorio de Genómica de Enfermedades Psiquiátricas y Neurodegenerativas, Instituto Nacional de Medicina Genómica, CDMX, México; Grupo de Estudios Médicos y Familiares Carracci, CDMX, México. Electronic address:

Schizophrenia (SCZ) and bipolar disorder (BD) cause similar symptomatology. A correlation between these disorders has been found. We aimed to explore shared CNVs between SCZ and BD, in 35 sibpairs diagnosed with SCZ and 21 sibpairs diagnosed with BD. Read More

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http://dx.doi.org/10.1016/j.psychres.2020.113018DOI Listing
May 2020
2.467 Impact Factor

Validity and utility of Hierarchical Taxonomy of Psychopathology (HiTOP): I. Psychosis superspectrum.

World Psychiatry 2020 Jun;19(2):151-172

Department of Psychology, University of Notre Dame, South Bend, IN, USA.

The Hierarchical Taxonomy of Psychopathology (HiTOP) is a scientific effort to address shortcomings of traditional mental disorder diagnoses, which suffer from arbitrary boundaries between psychopathology and normality, frequent disorder co-occurrence, heterogeneity within disorders, and diagnostic instability. This paper synthesizes evidence on the validity and utility of the thought disorder and detachment spectra of HiTOP. These spectra are composed of symptoms and maladaptive traits currently subsumed within schizophrenia, other psychotic disorders, and schizotypal, paranoid and schizoid personality disorders. Read More

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http://dx.doi.org/10.1002/wps.20730DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214958PMC

A case of delusional parasitosis presented as shared psychotic disorder treated successfully with aripiprazole.

Authors:
Derya Canlı

Indian J Psychiatry 2020 Mar-Apr;62(2):219-220. Epub 2020 Mar 17.

Department of Psychiatry, Amasya University Sabuncuoglu Serefeddin Education and Research Hospital, Amasya, Turkey. E-mail:

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http://dx.doi.org/10.4103/psychiatry.IndianJPsychiatry_285_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7197836PMC

Prevalence of and recovery from common mental disorder including psychotic experiences in the UK Primary Care Improving Access to Psychological Therapies (IAPT) Programme.

J Affect Disord 2020 Jul 3;272:84-90. Epub 2020 May 3.

Department of Psychiatry, University of Cambridge, Cambridge, CB2 0SZ, UK; National Institute for Health Research (NIHR) Applied Research Collaboration (ARC) East of England, Douglas House, Trumpinton Road, Cambridge, CB2 8AH, UK; Cambrigeshire and Peterborough NHS Foundation Trust, Elizabeth House, Fulbourn Hospital, Cambridge, CB21 5EF, UK; Norwich Medical School, University of East Anglia, Norwich, NR4 7TJ. Electronic address:

Background: Psychotic experiences (PE) may co-occur with common mental disorders (CMD), such as depression and anxiety. However, we know very little about the prevalence of and recovery from PE in primary mental health care settings, such as the Improving Access to Psychological Therapies (IAPT) services in the UK National Health Service (NHS), where most CMD are treated.

Methods: We used the Community Assessment of Psychic Experiences - Positive 15-item Scale (CAPE-P15) to determine the prevalence of PE in patients receiving treatment from IAPT services. Read More

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http://dx.doi.org/10.1016/j.jad.2020.04.015DOI Listing

'Come share my world' of 'madness': a systematic review of clinical, diagnostic and therapeutic aspects of .

Int Rev Psychiatry 2020 May 4:1-12. Epub 2020 May 4.

Department of Psychiatry, University of Perugia, Perugia, Italy.

, also known as shared psychotic disorder, shows intrinsic differences when compared to other psychiatric disorders. Literature about this condition is scanty and findings about its clinical correlates are not univocal. The present systematic review aimed at critically summarizing the existing evidence about , also focussing on psychopathological, diagnostic and treatment features. Read More

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http://dx.doi.org/10.1080/09540261.2020.1756754DOI Listing

Brain structural correlates of familial risk for mental illness: a meta-analysis of voxel-based morphometry studies in relatives of patients with psychotic or mood disorders.

Neuropsychopharmacology 2020 Jul 30;45(8):1369-1379. Epub 2020 Apr 30.

Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, 45219, USA.

Schizophrenia (SCZ), bipolar disorder (BD), and major depressive disorder (MDD) are heritable psychiatric disorders with partially overlapping genetic liability. Shared and disorder-specific neurobiological abnormalities associated with familial risk for developing mental illnesses are largely unknown. We performed a meta-analysis of structural brain imaging studies in relatives of patients with SCZ, BD, and MDD to identify overlapping and discrete brain structural correlates of familial risk for mental disorders. Read More

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http://dx.doi.org/10.1038/s41386-020-0687-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297956PMC
July 2020
7.048 Impact Factor

Role of rs454214 in Personality mediated Depression and Subjective Well-being.

Sci Rep 2020 Mar 30;10(1):5702. Epub 2020 Mar 30.

Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai, 200030, China.

Happiness and depression are interlinked and both heritable, while personality, as an important predictor of them, shares the genetic basis with them. We conjecture that genetic factors of depression can affect both depressive symptoms (DS) and subjective well-being (SWB), while personality traits play important roles in mediating this process. In this study, 878 Han Chinese college freshmen and 384 Han Chinese patients with the major depressive disorder (MDD) were included. Read More

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http://dx.doi.org/10.1038/s41598-020-62486-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105480PMC
March 2020
5.078 Impact Factor

World/self ambivalence: A shared mechanism in different subsets of psychotic experiences? Linking symptoms with resting-state fMRI.

Psychiatry Res Neuroimaging 2020 05 18;299:111068. Epub 2020 Mar 18.

University of Pavia, Department of Brain and Behavioral Sciences. Via Bassi 21, 27100, Pavia, Italy.

The psychosis spectrum comprises heterogeneous disorders characterized by both world-related and self-related symptoms. How these symptoms may arise with similar features in spite of the different aetiologies is yet an unsolved question. In behavior narrative review, we compare three conditions characterized by psychotic experiences (schizophrenia, substance-use disorder and sensory-deprivation) searching for links between their phenomenological features and the mechanisms underlying their onset. Read More

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http://dx.doi.org/10.1016/j.pscychresns.2020.111068DOI Listing

Genetic overlap between psychotic experiences in the community across age and with psychiatric disorders.

Transl Psychiatry 2020 Mar 9;10(1):86. Epub 2020 Mar 9.

Centre for Brain and Cognitive Development, Department of Psychological Sciences, Birkbeck, University of London, London, UK.

This study explores the degree to which genetic influences on psychotic experiences are stable across adolescence and adulthood, and their overlap with psychiatric disorders. Genome-wide association results were obtained for adolescent psychotic experiences and negative symptom traits (N = 6297-10,098), schizotypy (N = 3967-4057) and positive psychotic experiences in adulthood (N = 116,787-117,794), schizophrenia (N = 150,064), bipolar disorder (N = 41,653), and depression (N = 173,005). Linkage disequilibrium score regression was used to estimate genetic correlations. Read More

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http://dx.doi.org/10.1038/s41398-020-0765-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062754PMC

Psychiatric comorbidity among women with endometriosis: nationwide cohort study in Sweden.

Am J Obstet Gynecol 2020 Feb 26. Epub 2020 Feb 26.

Department of Global Public Health, Stockholm, Sweden; Center for Epidemiology and Community Medicine, Region Stockholm, Stockholm, Sweden.

Background: Endometriosis is a common gynecologic condition affecting women of reproductive age. It has been linked with greater rates of depression and anxiety in small, cross-sectional, and clinical studies. Other studies have reported that women with endometriosis have increased risk of bipolar disorder. Read More

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http://dx.doi.org/10.1016/j.ajog.2020.02.033DOI Listing
February 2020

Opioid use and schizophrenia.

Curr Opin Psychiatry 2020 May;33(3):219-224

Department of Veterans Affairs (VA) Boston Healthcare System, Brockton Division.

Purpose Of Review: To summarize the current literature regarding comorbid schizophrenia and opioid use disorder (OUD).

Recent Findings: Epidemiological evidence is unclear on whether patients with schizophrenia have a higher rate of OUD. Patients with OUD have been shown to have a higher risk of developing schizophrenia. Read More

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http://dx.doi.org/10.1097/YCO.0000000000000593DOI Listing

Women's Perception of Spousal Psychotic Disorders: A Qualitative Study.

Iran J Psychiatry 2019 Oct;14(4):317-324

School of Nursing, Iranian Research Center on Healthy Aging, Sabzevar University of Medical Sciences, Sabzevar, Iran.

Mental disorders are often accompanied by serious problems in personal and social communication, including marital problems. In this regard, women whose spouses have mental disorders are less likely to express their mental experiences and emotions due to the cultural barriers of the community. This study aimed to identify and explain the shared mental experiences of women whose spouses suffered from psychotic disorders. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7007512PMC
October 2019

Depression in Dementia or Dementia in Depression? Systematic Review of Studies and Hypotheses.

Curr Alzheimer Res 2020 ;17(1):16-28

Department of Old Age Psychiatry and Psychotic Disorders, Medical University of Lodz, Lodz, Poland.

The majority of research works to date suggest that Major Depressive Disorder (MDD) is a risk factor for dementia and may predispose to cognitive decline in both early and late onset variants. The presence of depression may not, however, reflect the cause, rather, an effect: it may be a response to cognitive impairment or alters the threshold at which cognitive impairment might manifest or be detected. An alternative hypothesis is that depression may be part of a prodrome to Alzheimer's Disease (AD), suggesting a neurobiological association rather than one of psychological response alone. Read More

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http://dx.doi.org/10.2174/1567205017666200217104114DOI Listing
January 2020

Multimodal imaging in a family with Cockayne syndrome with a novel pathogenic mutation in the ERCC8 gene, and significant phenotypic variability.

Doc Ophthalmol 2020 Feb 11. Epub 2020 Feb 11.

Loma Linda University Eye Institute, Loma Linda, CA, USA.

Background: Cockayne syndrome is a rare autosomal recessive neurodegenerative disorder caused by mutations of either the ERCC6/CSB or ERCC8/CSA genes. Here, we describe two sisters with Cockayne syndrome caused by compound heterozygous mutations in the ERCC8 gene using multimodal imaging. Significant ophthalmic and systemic phenotypic variability is discussed. Read More

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http://dx.doi.org/10.1007/s10633-020-09754-3DOI Listing
February 2020

Attention Deficit/Hyperactivity Disorder and risk for non-affective psychotic disorder: The role of ADHD medication and comorbidity, and sibling comparison.

Schizophr Res 2020 Apr 27;218:124-130. Epub 2020 Jan 27.

Department of Public Health Sciences, Division Public Health Epidemiology, Karolinska Institutet, Stockholm, Sweden; Center for Epidemiology and Community Medicine, Stockholm County Council, Stockholm, Sweden.

Attention Deficit/Hyperactivity Disorder (ADHD) is the most common psychiatric disorder in childhood. It is unclear whether ADHD increases the risk of non-affective psychotic disorder (NAPD). The study included a matched cohort, drawn from all born in Sweden 1987-1991 (n = 548,852). Read More

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http://dx.doi.org/10.1016/j.schres.2020.01.021DOI Listing

Psychiatric advance directives for people living with schizophrenia, bipolar I disorders, or schizoaffective disorders: Study protocol for a randomized controlled trial - DAiP study.

BMC Psychiatry 2019 12 27;19(1):422. Epub 2019 Dec 27.

School of medicine - La Timone Medical Campus, EA 3279: CEReSS - Health Service Research and Quality of Life Center, Aix-Marseille University, 27 Boulevard Jean Moulin, F-13005, Marseille Cedex 5, France.

Background: Compulsory admission to psychiatric hospital is rising despite serious ethical concerns. Among measures to reduce compulsory admissions, Psychiatric Advance Directives (PAD) are the most promising, with intensive PAD (i.e. Read More

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http://dx.doi.org/10.1186/s12888-019-2416-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6935101PMC
December 2019

Exploring the Relationship of Transdiagnostic Mood and Psychosis Symptom Domains with Motor Dysfunction.

Neuropsychobiology 2019 Dec 18:1-12. Epub 2019 Dec 18.

Department of Psychiatry, University of Minnesota, Minneapolis, Minnesota, USA.

Background: A number of motor abnormalities have been reported in psychotic disorders, including dyskinesia and psychomotor slowing. There is also evidence for many of the same motor abnormalities in biological first-degree relatives and accruing evidence for motor abnormalities in bipolar disorder. In addition to motor dysfunction, there are also shared symptom domains amongst these populations. Read More

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http://dx.doi.org/10.1159/000503928DOI Listing
December 2019

Identifying common genome-wide risk genes for major psychiatric traits.

Hum Genet 2020 Feb 7;139(2):185-198. Epub 2019 Dec 7.

Department of Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, 210029, China.

Major psychiatric traits are genetically inter-correlated with one another, but it not well known which genes play pleiotropic effects across different traits. We curated and compared genes identified from large-scale genome-wide association studies for seven psychiatric traits, including depression, bipolar disorder, schizophrenia, autism spectrum disorder, attention-deficit/hyperactivity disorder, anxiety and neuroticism. We then explored biological functions of the top pleiotropic genes. Read More

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http://dx.doi.org/10.1007/s00439-019-02096-4DOI Listing
February 2020
4.824 Impact Factor

Shared Psychotic Disorder (Folie À Deux): A Rare Case with Dissociative Trance Disorder That Can Be Induced.

Open Access Maced J Med Sci 2019 Aug 20;7(16):2701-2704. Epub 2019 Aug 20.

Department of Psychiatry, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia.

Background: Shared psychotic disorder was first introduced in the 19th century in France with the name Folie à deux. Since then, the concept of Folie à deux has been developed and produces several subtypes in France. In DSM, this disorder is called Shared Psychotic Disorder, and in ICD-10, it is called Induced Delusional Disorder. Read More

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http://dx.doi.org/10.3889/oamjms.2019.821DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6876800PMC

Structural brain morphometry associated with theory of mind in bipolar disorder and schizophrenia.

Psych J 2020 Apr 26;9(2):234-246. Epub 2019 Nov 26.

School of Psychiatry, University of New South Wales, Sydney, Australia.

Schizophrenia (SZ) and bipolar I disorder (BD) share common functional and structural brain abnormalities, as well as various degrees of social cognitive deficits, suggesting shared brain mechanisms. This study examined the relationship between social cognitive skills and structural brain integrity in 60 cases with SZ, 65 cases with psychotic BD, and 61 healthy controls (HCs). All participants underwent structural MRI and completed The Awareness of Social Inference Test (TASIT). Read More

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http://dx.doi.org/10.1002/pchj.322DOI Listing

Comparative genetic architectures of schizophrenia in East Asian and European populations.

Nat Genet 2019 12 18;51(12):1670-1678. Epub 2019 Nov 18.

Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.

Schizophrenia is a debilitating psychiatric disorder with approximately 1% lifetime risk globally. Large-scale schizophrenia genetic studies have reported primarily on European ancestry samples, potentially missing important biological insights. Here, we report the largest study to date of East Asian participants (22,778 schizophrenia cases and 35,362 controls), identifying 21 genome-wide-significant associations in 19 genetic loci. Read More

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http://dx.doi.org/10.1038/s41588-019-0512-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6885121PMC
December 2019
29.352 Impact Factor

A case series of shared delusional infestation: folie à deux revisited.

Clin Exp Dermatol 2020 Jun 20;45(4):414-416. Epub 2019 Dec 20.

Dermatology Department, Solihull Hospital, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.

Delusional infestation describes the unshakeable belief that one's skin is infected or infested with an external organism or inanimate material, in the absence of supportive medical evidence. It is one of the most challenging psychodermatological conditions to manage, given the rigidity of patients' physically focused health beliefs, and the competing need to introduce antipsychotic therapy to bring about resolution. This is rendered exponentially more complex when partners or family members are similarly afflicted. Read More

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http://dx.doi.org/10.1111/ced.14138DOI Listing

The psychopharmacology of epilepsy.

Authors:
Melissa Maguire

Handb Clin Neurol 2019 ;165:207-227

Department of Neurology, Leeds General Infirmary, Leeds, United Kingdom. Electronic address:

Epilepsy affects 1% of the world's population and is defined as two or more unprovoked seizures. Psychiatric conditions (depression, psychosis, anxiety, and attention deficit hyperactivity disorder (ADHD)) may coexist and are linked to negative seizure outcomes and poorer quality of life. There is an increasing body of evidence to suggest a bidirectional relationship between epilepsy and psychiatric disorders, which may imply shared pathophysiologic mechanisms. Read More

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http://dx.doi.org/10.1016/B978-0-444-64012-3.00012-5DOI Listing

Auditory sensory gating in young adolescents with early-onset psychosis: a comparison with attention deficit/hyperactivity disorder.

Neuropsychopharmacology 2020 03 24;45(4):649-655. Epub 2019 Oct 24.

Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS) and Center for Neuropsychiatric Schizophrenia Research (CNSR), Mental Health Centre Glostrup, Glostrup, Denmark.

Numerous studies have demonstrated impaired sensory gating in schizophrenia and this impairment has been proposed as a candidate biomarker for the disorder. The typical age of onset for schizophrenia is early adulthood, however a sizable group of patients present with psychotic symptoms before the age of 18, commonly referred to as early-onset psychosis (EOP). How an earlier onset influences sensory gating is currently unknown. Read More

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http://dx.doi.org/10.1038/s41386-019-0555-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7021818PMC
March 2020
1 Read

Association of Genetic Liability to Psychotic Experiences With Neuropsychotic Disorders and Traits.

JAMA Psychiatry 2019 Sep 25. Epub 2019 Sep 25.

MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, United Kingdom.

Importance: Psychotic experiences, such as hallucinations and delusions, are reported by approximately 5% to 10% of the general population, although only a small proportion develop psychotic disorders such as schizophrenia. Studying the genetic causes of psychotic experiences in the general population, and its association with the genetic causes of other disorders, may increase the understanding of their pathologic significance.

Objectives: To determine whether genetic liability to psychotic experiences is shared with schizophrenia and/or other neuropsychiatric disorders and traits and to identify genetic loci associated with psychotic experiences. Read More

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http://dx.doi.org/10.1001/jamapsychiatry.2019.2508DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764002PMC
September 2019
4 Reads

Clinical and genetic validity of quantitative bipolarity.

Transl Psychiatry 2019 09 16;9(1):228. Epub 2019 Sep 16.

Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, 21228, USA.

Research has yet to provide a comprehensive understanding of the genetic basis of bipolar disorder (BP). In genetic studies, defining the phenotype by diagnosis may miss risk-allele carriers without BP. The authors aimed to test whether quantitatively detected subclinical symptoms of bipolarity identifies a heritable trait that infers risk for BP. Read More

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http://dx.doi.org/10.1038/s41398-019-0561-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6746871PMC
September 2019
3 Reads

Delusions of Parasitosis: An Update.

Dermatol Ther (Heidelb) 2019 Dec 13;9(4):631-638. Epub 2019 Sep 13.

Lower Silesian Mental Health Center, Wroclaw, Poland.

Delusional parasitosis, also known as delusional infestation or Ekbom syndrome, is a relatively infrequent psychotic disorder characterized by an unwavering false belief that there is a parasitic infestation of the skin, despite the absence of any medical evidence that could support this claim. Delusional parasitosis can be categorized into primary, secondary, and organic forms. Sometimes, close relatives also experience identical delusions. Read More

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http://link.springer.com/10.1007/s13555-019-00324-3
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http://dx.doi.org/10.1007/s13555-019-00324-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6828902PMC
December 2019
6 Reads

Impact of integrated district level mental health care on clinical and social outcomes of people with severe mental illness in rural Ethiopia: an intervention cohort study.

Epidemiol Psychiatr Sci 2019 Aug 13;29:e45. Epub 2019 Aug 13.

WHO Collaborating Centre for Mental Health Research and Capacity Building, Department of Psychiatry, Addis Ababa University, College of Health Sciences, School of Medicine, Addis Ababa, Ethiopia.

Aim: There is limited evidence of the safety and impact of task-shared care for people with severe mental illnesses (SMI; psychotic disorders and bipolar disorder) in low-income countries. The aim of this study was to evaluate the safety and impact of a district-level plan for task-shared mental health care on 6 and 12-month clinical and social outcomes of people with SMI in rural southern Ethiopia.

Methods: In the Programme for Improving Mental health carE, we conducted an intervention cohort study. Read More

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https://www.cambridge.org/core/product/identifier/S204579601
Publisher Site
http://dx.doi.org/10.1017/S2045796019000398DOI Listing
August 2019
6 Reads

Transdiagnostic Multimodal Neuroimaging in Psychosis: Structural, Resting-State, and Task Magnetic Resonance Imaging Correlates of Cognitive Control.

Biol Psychiatry Cogn Neurosci Neuroimaging 2019 10 20;4(10):870-880. Epub 2019 May 20.

Department of Psychiatry, Washington University in St. Louis, St. Louis, Missouri.

Background: Disorders with psychotic features, including schizophrenia and some bipolar disorders, are associated with impairments in regulation of goal-directed behavior, termed cognitive control. Cognitive control-related neural alterations have been studied in psychosis. However, studies are typically unimodal, and relationships across modalities of brain function and structure remain unclear. Read More

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http://dx.doi.org/10.1016/j.bpsc.2019.05.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6842450PMC
October 2019
8 Reads

The relationship between nicotine and psychosis.

Ther Adv Psychopharmacol 2019 1;9:2045125319859969. Epub 2019 Jul 1.

Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, Kings College London, London, UK.

Cigarette smoking is strongly associated with psychotic disorders such as schizophrenia. For several decades it was assumed that the relationship could be explained by reverse causation; that smoking was secondary to the illness itself, either through self-medication or a process of institutionalization, or was entirely explained by confounding by cannabis use or social factors. However, studies have exposed that such hypotheses cannot fully explain the association, and more recently a bidirectional relationship has been proposed wherein cigarette smoking may be causally related to risk of psychosis, possibly a shared genetic liability to smoking and psychosis. Read More

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http://dx.doi.org/10.1177/2045125319859969DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6604123PMC
July 2019
4 Reads

Association of Genetic Risk for Rheumatoid Arthritis With Cognitive and Psychiatric Phenotypes Across Childhood and Adolescence.

JAMA Netw Open 2019 06 5;2(6):e196118. Epub 2019 Jun 5.

Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, United Kingdom.

Importance: The association of rheumatoid arthritis (RA) with cognitive and psychiatric phenotypes has been recognized. However, it is not known whether these phenotypes are a consequence of disease-related factors, such as pain, or reflect shared etiological factors.

Objective: To investigate whether genomic risk for RA is associated with cognitive and psychiatric symptoms in children and adolescents. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2019.6118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593640PMC
June 2019
12 Reads

[Folie à deux, symptoms sharing us a relationship modality: a case report].

Pan Afr Med J 2019 28;32:47. Epub 2019 Jan 28.

Service de Psychiatrie, Centre Hospitalier Universitaire Hassan II, Fès, Maroc.

Shared Psychotic Disorder or Folie à deux is a rare and controversial entity that raises phenomenological, nosographic and psychopathological issues. It questions the nature of dilusion and its occurrence outside the psychotic structure and also the issue of symptoms contagion in psychiatry. We offer a semiological analysis of an intrafamilial case of Folie à deux, a case with the clinical specificity of sharing not only delusional symptoms but also non-delusional psychotic elements. Read More

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http://dx.doi.org/10.11604/pamj.2019.32.47.8378DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6522158PMC
June 2019
13 Reads

Testing the expanded continuum hypothesis of schizophrenia and bipolar disorder. Neural and psychological evidence for shared and distinct mechanisms.

Neuroimage Clin 2019 4;23:101854. Epub 2019 May 4.

Department of Psychology and Cognitive Science (DiPSCo), University of Trento, Rovereto, Italy. Electronic address:

Despite the traditional view of Schizophrenia (SZ) and Bipolar disorder (BD) as separate diagnostic categories, the validity of such a categorical approach is challenging. In recent years, the hypothesis of a continuum between Schizophrenia (SZ) and Bipolar disorder (BD), postulating a common pathophysiologic mechanism, has been proposed. Although appealing, this unifying hypothesis may be too simplistic when looking at cognitive and affective differences these patients display. Read More

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http://dx.doi.org/10.1016/j.nicl.2019.101854DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6529770PMC
March 2020
10 Reads

Extreme Overvalued Belief and the Legacy of Carl Wernicke.

J Am Acad Psychiatry Law 2019 Jun 13;47(2):180-187. Epub 2019 May 13.

Dr. Rahman is Associate Professor of Psychiatry, Washington University in St. Louis, School of Medicine. Dr. Meloy is Clinical Professor, Department of Psychiatry, University of California, San Diego, School of Medicine. Dr. Bauer is Resident Psychiatrist, Washington University in St. Louis, Missouri.

Individuals with extreme overvalued beliefs often carry out abhorrent and inexplicable acts of violence. They hold odd and bizarre beliefs that are shared by others in their culture or subculture. This creates a dilemma for the forensic psychiatrist because the definition of delusion may not be adequate. Read More

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http://dx.doi.org/10.29158/JAAPL.003847-19DOI Listing
June 2019
37 Reads

[Depression in women - the victims of domestic violence (forensic psychiatry aspects)].

Zh Nevrol Psikhiatr Im S S Korsakova 2019 ;119(1. Vyp. 2):34-38

Serbsky National Medical Research Centre for Psychiatry and Narcology Ministry of Health of RF, Moscow, Russia.

Aim: To study the development of depressive disorders in women, the victims of domestic violence, who committed aggressive acts.

Material And Methods: Patients (n=12) were divided into two groups depending on acute depressive reaction in response to violence from husbands, which resulted in criminal acts. The first group included 4 women who killed their children and the second group included 8 women who killed their husbands. Read More

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http://dx.doi.org/10.17116/jnevro20191191234DOI Listing
August 2019
19 Reads

Mutations From Whole Exome Sequencing in Neurodevelopmental and Psychiatric Disorders: From Discovery to Application.

Front Genet 2019 3;10:258. Epub 2019 Apr 3.

Shanghai Mental Health Center, School of Biomedical Engineering, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Neurodevelopmental and psychiatric disorders are a highly disabling and heterogeneous group of developmental and mental disorders, resulting from complex interactions of genetic and environmental risk factors. The nature of multifactorial traits and the presence of comorbidity and polygenicity in these disorders present challenges in both disease risk identification and clinical diagnoses. The genetic component has been firmly established, but the identification of all the causative variants remains elusive. Read More

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https://www.frontiersin.org/article/10.3389/fgene.2019.00258
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http://dx.doi.org/10.3389/fgene.2019.00258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456656PMC
April 2019
20 Reads

Shared Obsessive-Compulsive Disorder: An Italian Case Report.

J Nerv Ment Dis 2019 04;207(4):311-313

Department of Neuroscience and Mental Health, Clinical Psychopharmacology Unit, Fondazione IRCCS Ospedale Maggiore Policlinico.

Shared obsessive-compulsive disorder (S-OCD) has seldom been reported in the literature, whereas shared psychotic disorder has been described since the end of 19th century. The aim of this report was to describe a case of S-OCD in a married couple. A 38-year-old OCD patient, after several pharmacological trials, eventually improved when a combination of escitalopram and risperidone was prescribed. Read More

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http://dx.doi.org/10.1097/NMD.0000000000000967DOI Listing
April 2019
7 Reads

Comparison of automatic visual attention in schizophrenia, bipolar disorder, and major depression: Evidence from P1 event-related component.

Psychiatry Clin Neurosci 2019 Jun 10;73(6):331-339. Epub 2019 Apr 10.

Department of General Psychology, University of Padua, Padua, Italy.

Aim: The ability to discern commonalities and differences in the neurobiology of functional psychoses represents a key element to unmasking shared vulnerability across different psychiatric conditions. The present study sought to compare the automatic visual attention mechanisms in three psychiatric disorders considered to distribute along the continuum of psychosis severity: schizophrenia (SCZ), bipolar disorder (BD), and major depressive disorder (MDD). To this end, the visual P1 event-related potential component, a cortical correlate of automatic visual attention, was measured during an ecological task based on visual word pair presentation. Read More

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http://dx.doi.org/10.1111/pcn.12840DOI Listing
June 2019
11 Reads

Performing Together: Monozygotic Twin Comedians/Twin research: Mirror-Image Cleft Lip and Palate; Dental Caries; Noninvasive Prenatal testing; Capgras Syndrome with Folie à Deux/In the News: Athletic Twins; Transgendered Twins; Crib-Sharing; Common Careers.

Authors:
Nancy L Segal

Twin Res Hum Genet 2019 02 11;22(1):70-74. Epub 2019 Feb 11.

Department of Psychology,California State University,Fullerton, CA,USA.

Twin studies have shown that our sense of humor has an underlying genetic component, but less investigation of the origins of stand-up comedy has been undertaken. This article briefly reviews twin research findings on humor, then describes the working partnership and social affiliation of a pair of monozygotic male twins who perform together as stand-up comedians. The abilities, personalities and temperaments of these twins suggest future avenues for research in this interesting area. Read More

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http://dx.doi.org/10.1017/thg.2018.74DOI Listing
February 2019
10 Reads

Neuroanatomical deficits shared by youth with autism spectrum disorders and psychotic disorders.

Hum Brain Mapp 2019 04 19;40(5):1643-1653. Epub 2018 Dec 19.

Department of Child and Adolescent Psychiatry, Hospital General Universitario Gregorio Marañón, Madrid, Spain.

Autism spectrum disorders (ASD) and early-onset psychosis (EOP) are neurodevelopmental disorders that share genetic, clinical and cognitive facets; it is unclear if these disorders also share spatially overlapping cortical thickness (CT) and surface area (SA) abnormalities. MRI scans of 30 ASD, 29 patients with early-onset first-episode psychosis (EO-FEP) and 26 typically developing controls (TD) (age range 10-18 years) were analyzed by the FreeSurfer suite to calculate vertex-wise estimates of CT, SA, and cortical volume. Two publicly available datasets of ASD and EOP (age range 7-18 years and 5-17 years, respectively) were used for replication analysis. Read More

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http://dx.doi.org/10.1002/hbm.24475DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6865706PMC
April 2019
15 Reads

Clinical, neurocognitive and demographic factors associated with functional impairment in the Australian Brain and Mind Youth Cohort Study (2008-2016).

BMJ Open 2018 12 18;8(12):e022659. Epub 2018 Dec 18.

Brain and Mind Centre, University of Sydney, Sydney, New South Wales, Australia.

Objectives: We sought to determine the unique and shared contributions of clinical, neurocognitive and demographic factors to functional impairment in a large, transdiagnostic, clinical cohort of adolescents and young adults.

Design: Cross-sectional baseline data from a prospective, cohort study.

Setting: Help-seeking youth referred from outpatient services were recruited to the (2008-2016) in Sydney, Australia. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-022659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303611PMC
December 2018
22 Reads

Talking about trauma in therapy: Perspectives from young people with post-traumatic stress symptoms and first episode psychosis.

Early Interv Psychiatry 2019 10 9;13(5):1236-1244. Epub 2018 Dec 9.

Orygen, The National Centre of Excellence in Youth Mental Health, Parkville, Victoria, Australia.

Aim: Despite recommendations from national guidelines, individuals with first episode psychosis (FEP) are currently unlikely to have the effects of their traumatic experiences assessed and treated within psychosis treatment. This may be due to the mismatch between the objectives of trauma-specific treatments (directly targeting post-traumatic stress symptoms by talking about the trauma) and trauma-informed care (limiting practices that may retraumatise clients). We aimed to gain an understanding of what it was like for young people to talk about trauma in FEP treatment, and how their experiences related to the broad conceptualisations of trauma-informed and trauma-specific treatment approaches. Read More

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http://dx.doi.org/10.1111/eip.12761DOI Listing
October 2019
3 Reads

PET neuroimaging reveals histone deacetylase dysregulation in schizophrenia.

J Clin Invest 2019 01 10;129(1):364-372. Epub 2018 Dec 10.

Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA.

Background: Patients with schizophrenia (SCZ) experience chronic cognitive deficits. Histone deacetylases (HDACs) are enzymes that regulate cognitive circuitry; however, the role of HDACs in cognitive disorders, including SCZ, remains unknown in humans. We previously determined that HDAC2 mRNA levels were lower in dorsolateral prefrontal cortex (DLPFC) tissue from donors with SCZ compared with controls. Read More

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http://dx.doi.org/10.1172/JCI123743DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307962PMC
January 2019
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The metabolic basis of psychosis in bipolar disorder: A positron emission tomography study.

Bipolar Disord 2019 03 1;21(2):151-158. Epub 2018 Dec 1.

Department of Neurosciences and Mental Health, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy.

Objectives: Psychotic symptoms are a common feature in bipolar disorder (BD), especially during manic phases, and are associated with a more severe course of illness. However, not all bipolar subjects experience psychosis during the course of their illness, and this difference often guides assessment and pharmacological treatment. The aim of the present study is to elucidate, for the first time, the FDG uptake dysfunctions associated with psychosis in BD patients with and without a history of past psychotic symptoms, through a positron emission tomography (PET) approach. Read More

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http://dx.doi.org/10.1111/bdi.12710DOI Listing
March 2019
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Folie à deux and homicide: Literature review and study of a complex clinical case.

Int J Law Psychiatry 2018 Nov - Dec;61:30-39. Epub 2018 Oct 13.

Service de pédopsychiatrie, CHU Sainte Marguerite, 270 boulevard de Sainte Marguerite, 13274 Marseille Cedex 9, France; Faculté de medecine de Marseille, Aix-Marseille Université, France. Electronic address:

Folie à deux is a psychiatric illness involved in homicides.

Objective: To study the mechanisms leading to homicide and determine homicide risk factors in folie à deux patients through a literature review and the study of a complex clinical case.

Materials And Methods: We included articles available on PubMed, ScienceDirect or Cairn that address the forensic implications of folie à deux. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01602527183003
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http://dx.doi.org/10.1016/j.ijlp.2018.10.001DOI Listing
June 2019
13 Reads

Increased Risk for Neurodevelopmental Disorders in Children With Orofacial Clefts.

J Am Acad Child Adolesc Psychiatry 2018 11 18;57(11):876-883. Epub 2018 Sep 18.

Uppsala University, Sweden.

Objective: Children with orofacial clefts (OFC) may have an increased risk of poor mental health. This study aimed to investigate the risk of psychiatric diagnoses in individuals with OFC, stratified by cleft type.

Method: A nationwide register-based cohort of all individuals born with nonsyndromic OFC in Sweden between 1973 and 2012 (n = 7,842) was compared to a matched cohort (n = 78,409) as well as to their unaffected siblings (n = 9,637). Read More

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http://dx.doi.org/10.1016/j.jaac.2018.06.024DOI Listing
November 2018
45 Reads

Peripheral blood E2F1 mRNA in depression and following electroconvulsive therapy.

Prog Neuropsychopharmacol Biol Psychiatry 2019 03 24;89:380-385. Epub 2018 Oct 24.

Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland; Department of Psychiatry, Trinity College Dublin, St Patrick's University Hospital, Dublin 8, Ireland. Electronic address:

The E2F transcription factors are a group of proteins that bind to the promotor region of the adenovirus E2 gene. E2F1, the first family member to be cloned, is linked to functions including cell proliferation and apoptosis, DNA repair, cell senescence and metabolism. We recently performed a deep sequencing study of micro-RNA changes in whole blood following ECT. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02785846183058
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http://dx.doi.org/10.1016/j.pnpbp.2018.10.011DOI Listing
March 2019
14 Reads