704 results match your criteria Shared Psychotic Disorder


Shared Obsessive-Compulsive Disorder: An Italian Case Report.

J Nerv Ment Dis 2019 Apr;207(4):311-313

Department of Neuroscience and Mental Health, Clinical Psychopharmacology Unit, Fondazione IRCCS Ospedale Maggiore Policlinico.

Shared obsessive-compulsive disorder (S-OCD) has seldom been reported in the literature, whereas shared psychotic disorder has been described since the end of 19th century. The aim of this report was to describe a case of S-OCD in a married couple. A 38-year-old OCD patient, after several pharmacological trials, eventually improved when a combination of escitalopram and risperidone was prescribed. Read More

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http://dx.doi.org/10.1097/NMD.0000000000000967DOI Listing
April 2019
1 Read

Comparison of automatic visual attention in schizophrenia, bipolar disorder, and major depression: Evidence from P1 event-related component.

Psychiatry Clin Neurosci 2019 Mar 18. Epub 2019 Mar 18.

Department of General Psychology, University of Padua, Padua, Italy.

Aim: The ability to discern commonalities and differences in the neurobiology of functional psychoses represents a key element to unmasking shared vulnerability across different psychiatric conditions. The present study sought to compare the automatic visual attention mechanisms in three psychiatric disorders considered to distribute along the continuum of psychosis severity: schizophrenia (SCZ), bipolar disorder (BD), and major depressive disorder (MDD). To this end, the visual P1 event-related potential component, a cortical correlate of automatic visual attention, was measured during an ecological task based on visual word pair presentation. Read More

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http://dx.doi.org/10.1111/pcn.12840DOI Listing
March 2019
2 Reads

Performing Together: Monozygotic Twin Comedians/Twin research: Mirror-Image Cleft Lip and Palate; Dental Caries; Noninvasive Prenatal testing; Capgras Syndrome with Folie à Deux/In the News: Athletic Twins; Transgendered Twins; Crib-Sharing; Common Careers.

Authors:
Nancy L Segal

Twin Res Hum Genet 2019 02 11;22(1):70-74. Epub 2019 Feb 11.

Department of Psychology,California State University,Fullerton, CA,USA.

Twin studies have shown that our sense of humor has an underlying genetic component, but less investigation of the origins of stand-up comedy has been undertaken. This article briefly reviews twin research findings on humor, then describes the working partnership and social affiliation of a pair of monozygotic male twins who perform together as stand-up comedians. The abilities, personalities and temperaments of these twins suggest future avenues for research in this interesting area. Read More

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http://dx.doi.org/10.1017/thg.2018.74DOI Listing
February 2019

Neuroanatomical deficits shared by youth with autism spectrum disorders and psychotic disorders.

Hum Brain Mapp 2019 Apr 19;40(5):1643-1653. Epub 2018 Dec 19.

Department of Child and Adolescent Psychiatry, Hospital General Universitario Gregorio Marañón, Madrid, Spain.

Autism spectrum disorders (ASD) and early-onset psychosis (EOP) are neurodevelopmental disorders that share genetic, clinical and cognitive facets; it is unclear if these disorders also share spatially overlapping cortical thickness (CT) and surface area (SA) abnormalities. MRI scans of 30 ASD, 29 patients with early-onset first-episode psychosis (EO-FEP) and 26 typically developing controls (TD) (age range 10-18 years) were analyzed by the FreeSurfer suite to calculate vertex-wise estimates of CT, SA, and cortical volume. Two publicly available datasets of ASD and EOP (age range 7-18 years and 5-17 years, respectively) were used for replication analysis. Read More

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http://dx.doi.org/10.1002/hbm.24475DOI Listing
April 2019
5 Reads

Clinical, neurocognitive and demographic factors associated with functional impairment in the Australian Brain and Mind Youth Cohort Study (2008-2016).

BMJ Open 2018 Dec 18;8(12):e022659. Epub 2018 Dec 18.

Brain and Mind Centre, University of Sydney, Sydney, New South Wales, Australia.

Objectives: We sought to determine the unique and shared contributions of clinical, neurocognitive and demographic factors to functional impairment in a large, transdiagnostic, clinical cohort of adolescents and young adults.

Design: Cross-sectional baseline data from a prospective, cohort study.

Setting: Help-seeking youth referred from outpatient services were recruited to the (2008-2016) in Sydney, Australia. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-022659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303611PMC
December 2018
4 Reads

The metabolic basis of psychosis in bipolar disorder: A positron emission tomography study.

Bipolar Disord 2019 Mar 1;21(2):151-158. Epub 2018 Dec 1.

Department of Neurosciences and Mental Health, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy.

Objectives: Psychotic symptoms are a common feature in bipolar disorder (BD), especially during manic phases, and are associated with a more severe course of illness. However, not all bipolar subjects experience psychosis during the course of their illness, and this difference often guides assessment and pharmacological treatment. The aim of the present study is to elucidate, for the first time, the FDG uptake dysfunctions associated with psychosis in BD patients with and without a history of past psychotic symptoms, through a positron emission tomography (PET) approach. Read More

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http://dx.doi.org/10.1111/bdi.12710DOI Listing
March 2019
3 Reads

Increased Risk for Neurodevelopmental Disorders in Children With Orofacial Clefts.

J Am Acad Child Adolesc Psychiatry 2018 Nov 18;57(11):876-883. Epub 2018 Sep 18.

Uppsala University, Sweden.

Objective: Children with orofacial clefts (OFC) may have an increased risk of poor mental health. This study aimed to investigate the risk of psychiatric diagnoses in individuals with OFC, stratified by cleft type.

Method: A nationwide register-based cohort of all individuals born with nonsyndromic OFC in Sweden between 1973 and 2012 (n = 7,842) was compared to a matched cohort (n = 78,409) as well as to their unaffected siblings (n = 9,637). Read More

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http://dx.doi.org/10.1016/j.jaac.2018.06.024DOI Listing
November 2018
10 Reads

Peripheral blood E2F1 mRNA in depression and following electroconvulsive therapy.

Prog Neuropsychopharmacol Biol Psychiatry 2019 03 24;89:380-385. Epub 2018 Oct 24.

Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland; Department of Psychiatry, Trinity College Dublin, St Patrick's University Hospital, Dublin 8, Ireland. Electronic address:

The E2F transcription factors are a group of proteins that bind to the promotor region of the adenovirus E2 gene. E2F1, the first family member to be cloned, is linked to functions including cell proliferation and apoptosis, DNA repair, cell senescence and metabolism. We recently performed a deep sequencing study of micro-RNA changes in whole blood following ECT. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02785846183058
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http://dx.doi.org/10.1016/j.pnpbp.2018.10.011DOI Listing
March 2019
3 Reads

Genetic Predisposition vs Individual-Specific Processes in the Association Between Psychotic-like Experiences and Cannabis Use.

JAMA Psychiatry 2019 Jan;76(1):87-94

Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri.

Importance: Previous research indicates that cannabis use is associated with psychotic-like experiences (PLEs). However, it is unclear whether this association results from predispositional (ie, shared genetic) factors or individual-specific factors (eg, causal processes, such as cannabis use leading to PLEs).

Objectives: To estimate genetic and environmental correlations between cannabis use and PLEs, and to examine PLEs in twin and nontwin sibling pairs discordant for exposure to cannabis use to disentangle predispositional from individual-specific effects. Read More

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http://dx.doi.org/10.1001/jamapsychiatry.2018.2546DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400636PMC
January 2019
5 Reads

Shared psychotic disorder in children and young people: a systematic review.

Eur Child Adolesc Psychiatry 2018 Oct 17. Epub 2018 Oct 17.

Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.

This study aimed at searching the literature and reassessing the concept of shared psychotic disorder (SPD) in young people under 18 taking into account genetic vulnerability, social circumstances and family situation to have a better understanding of this condition. Published case reports from 1980 through to March 2017, which included children and adolescents meeting DSM-III/IV/IV-TR or ICD 10 criteria of SPD, were identified. Sociodemographic and clinical variables were collected and analysed; a post hoc analysis comparing inductors and induced was also conducted. Read More

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http://link.springer.com/10.1007/s00787-018-1236-7
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http://dx.doi.org/10.1007/s00787-018-1236-7DOI Listing
October 2018
15 Reads

Next-generation sequencing analysis of multiplex families with atypical psychosis.

Transl Psychiatry 2018 10 15;8(1):221. Epub 2018 Oct 15.

Department of Neuropsychiatry, Osaka Medical College, Osaka, Japan.

Atypical psychosis (similar to acute and transient psychotic disorder, brief psychotic disorder) is highly heritable, but the causal genes remain unidentified. We conducted whole-genome sequencing on multiplex Japanese families with atypical psychosis. The patient group of interest shows acute psychotic features including hallucinations, delusions, and catatonic symptoms while they often show good prognosis after the onset. Read More

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http://www.nature.com/articles/s41398-018-0272-x
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http://dx.doi.org/10.1038/s41398-018-0272-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6189064PMC
October 2018
21 Reads

Contrasting mental health correlates of physical and sexual abuse-related shame.

J Child Adolesc Ment Health 2018 Aug;30(2):87-97

a School of Social Work , Memorial University of Newfoundland , Saint John's , Canada.

Objective: This study represents an initial attempt to contrast behavioural and mental health correlates of shame as a result of physical abuse (PA) and sexual abuse (SA). Because they are distinctive forms of injury, it is possible that corollary shame from these injuries follows unique trajectories and ultimately results in different health challenges.

Method: Self-report data from a survey on the health of youth receiving protective services for reasons of PA and SA was used. Read More

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http://dx.doi.org/10.2989/17280583.2018.1485569DOI Listing
August 2018
3 Reads

A case of Capgras syndrome and folie à duex in monozygotic twins.

Neurocase 2018 Jun 24;24(3):175-179. Epub 2018 Aug 24.

a Psychiatric Centre Copenhagen , Copenhagen University Hospital , Copenhagen , Denmark.

Both Capgras syndrome and folie à deux (insanity of two) are rare and fascinating psychopathological syndromes. Their etiology and the nosological position remain unclear. We present a case of substance-induced Capgras syndrome emerging as folie à deux (insanity of two) in monozygotic twins with strongly overlapping life histories. Read More

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https://www.tandfonline.com/doi/full/10.1080/13554794.2018.1
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http://dx.doi.org/10.1080/13554794.2018.1512633DOI Listing
June 2018
21 Reads

Longitudinal associations between psychotic experiences and disordered eating behaviours in adolescence: a UK population-based study.

Lancet Child Adolesc Health 2018 08 22;2(8):591-599. Epub 2018 Jun 22.

Division of Psychiatry, University College London, London, UK.

Background: Psychotic experiences might represent non-specific markers of poor mental health in adolescence. However, only a few predominantly cross-sectional studies have tested their association with disordered eating behaviours in adolescent and adult populations. The aim of this study was to explore the association between psychotic experiences at age 13 years, and disordered eating behaviours and body-mass index (BMI) at age 18 years. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S23524642183018
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http://dx.doi.org/10.1016/S2352-4642(18)30180-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054050PMC
August 2018
8 Reads

Use of schizophrenia and bipolar disorder polygenic risk scores to identify psychotic disorders.

Br J Psychiatry 2018 Sep;213(3):535-541

Division of Psychiatry and Institute of Cognitive Neuroscience,University College London and Institute of Psychiatry, Psychology and Neuroscience, King's College London and South London and Maudsley NHS Foundation Trust,UK.

Background: There is increasing evidence for shared genetic susceptibility between schizophrenia and bipolar disorder. Although genetic variants only convey subtle increases in risk individually, their combination into a polygenic risk score constitutes a strong disease predictor.AimsTo investigate whether schizophrenia and bipolar disorder polygenic risk scores can distinguish people with broadly defined psychosis and their unaffected relatives from controls. Read More

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http://dx.doi.org/10.1192/bjp.2018.89DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130805PMC
September 2018
6 Reads
7.991 Impact Factor

Delusional Parasitosis: Diagnosis and Treatment.

Isr Med Assoc J 2018 Jul;20(7):456-460

Department of Psychiatry, Hadassah-Hebrew University Medical Center, Ein Kerem Campus, Jerusalem, Israel.

Background: Delusional parasitosis (DP) is a somatic type of delusional disorder, usually mono-symptomatic, in which the patients are convinced they are being infested with animal parasites while no objective evidence exists to support this belief. The complaints are usually about skin infestation, but involvement of the gastrointestinal tract has also been described. Numerous samples are brought for examination from skin, clothes, and environmental sources, while a detailed description of the "parasite" is given. Read More

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July 2018
6 Reads

Investigating the genetic architecture of general and specific psychopathology in adolescence.

Transl Psychiatry 2018 08 8;8(1):145. Epub 2018 Aug 8.

Centre for Academic Mental Health, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.

Whilst associations between polygenic risk scores (PRSs) for schizophrenia and various phenotypic outcomes have been reported, an understanding of developmental pathways can only be gained by modelling comorbidity across psychopathology. We examine how genetic risk for schizophrenia relates to adolescent psychosis-related and internalizing psychopathology using a latent modelling approach, and compare this to genetic risk for other psychiatric disorders, to gain a more comprehensive understanding of the developmental pathways at this age. PRSs for schizophrenia, major depressive disorder, neuroticism and bipolar disorder were generated for individuals in the Avon Longitudinal Study of Parents and Children (ALSPAC) birth cohort. Read More

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http://dx.doi.org/10.1038/s41398-018-0204-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6082910PMC
August 2018
11 Reads

Brain and Behavior: Commentary on Two Cases Involving the Effect of Structural Brain Lesions on Psychiatric Disorders.

Authors:
David A Kahn

J Psychiatr Pract 2018 May;24(3):206-208

KAHN: Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY.

In this issue of the journal, 2 case reports are presented that illustrate explicit influences of structural brain lesions on psychiatric symptoms. In both cases, the patients had preexisting, classically diagnosed psychiatric disorders-schizophrenia in the first case and bipolar I disorder in the second case. In the first case, a 61-year-old woman with chronic paranoid schizophrenia experienced a marked reduction in psychotic symptoms after bilateral frontal strokes. Read More

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http://dx.doi.org/10.1097/PRA.0000000000000302DOI Listing
May 2018
7 Reads

Understanding the lived experience of cognitive remediation in schizophrenia: A qualitative comparison with an active control.

Psychiatr Rehabil J 2018 Dec 16;41(4):302-311. Epub 2018 Jul 16.

School of Psychological Sciences.

Objective: Cognitive remediation (CR) is a promising method of improving cognitive functioning in people with schizophrenia. Nevertheless, the lived experience of participation, and whether this differs from computer game (CG) playing control conditions, remains poorly understood. This study aimed to qualitatively compare the experience of participating in these 2 interventions. Read More

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http://dx.doi.org/10.1037/prj0000309DOI Listing
December 2018
4 Reads

Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes.

Authors:

Cell 2018 06;173(7):1705-1715.e16

Schizophrenia and bipolar disorder are two distinct diagnoses that share symptomology. Understanding the genetic factors contributing to the shared and disorder-specific symptoms will be crucial for improving diagnosis and treatment. In genetic data consisting of 53,555 cases (20,129 bipolar disorder [BD], 33,426 schizophrenia [SCZ]) and 54,065 controls, we identified 114 genome-wide significant loci implicating synaptic and neuronal pathways shared between disorders. Read More

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http://dx.doi.org/10.1016/j.cell.2018.05.046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432650PMC
June 2018
27 Reads

A Contagious Disorder: Folie à Deux and Dementia.

Am J Alzheimers Dis Other Demen 2018 11 17;33(7):415-422. Epub 2018 May 17.

2 Department of Psychiatry, Versilia Hospital, Lucca, Italy.

Background: Folie à deux is a clinical condition that was first described in 19th century. It is a psychotic disorder in which two closely associated individuals share a similar delusional system.

Objectives: The aim of this article is to review the nosological significance of folie à deux and to explore the disorder among patients with dementia. Read More

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http://dx.doi.org/10.1177/1533317518772060DOI Listing
November 2018
9 Reads
1.426 Impact Factor

A data-driven investigation of relationships between bipolar psychotic symptoms and schizophrenia genome-wide significant genetic loci.

Am J Med Genet B Neuropsychiatr Genet 2018 06 19;177(4):468-475. Epub 2018 Apr 19.

MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University Institute of Psychological Medicine and Clinical Neurosciences, Cardiff, United Kingdom.

The etiologies of bipolar disorder (BD) and schizophrenia include a large number of common risk alleles, many of which are shared across the disorders. BD is clinically heterogeneous and it has been postulated that the pattern of symptoms is in part determined by the particular risk alleles carried, and in particular, that risk alleles also confer liability to schizophrenia influence psychotic symptoms in those with BD. To investigate links between psychotic symptoms in BD and schizophrenia risk alleles we employed a data-driven approach in a genotyped and deeply phenotyped sample of subjects with BD. Read More

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http://doi.wiley.com/10.1002/ajmg.b.32635
Publisher Site
http://dx.doi.org/10.1002/ajmg.b.32635DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001555PMC
June 2018
16 Reads

A Twin Study of Normative Personality and DSM-IV Personality Disorder Criterion Counts: Evidence for Separate Genetic Influences.

Am J Psychiatry 2018 Jul 21;175(7):649-656. Epub 2018 Mar 21.

From the Department of Psychology and the Institute of Clinical Medicine, University of Oslo, Oslo; the Division of Mental Health, Norwegian Institute of Public Health, Oslo; the Virginia Institute for Psychiatric and Behavioral Genetics, the Department of Psychiatry, and the Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond; and the Department of Psychology, University of Minnesota, Minneapolis.

Objective: Both normative personality and DSM-IV personality disorders have been found to be heritable. However, there is limited knowledge about the extent to which the genetic and environmental influences underlying DSM personality disorders are shared with those of normative personality. The aims of this study were to assess the phenotypic similarity between normative and pathological personality and to investigate the extent to which genetic and environmental influences underlying individual differences in normative personality account for symptom variance across DSM-IV personality disorders. Read More

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http://dx.doi.org/10.1176/appi.ajp.2017.17050493DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028291PMC
July 2018
17 Reads

C4A mRNA expression in PBMCs predicts the presence and severity of delusions in schizophrenia and bipolar disorder with psychosis.

Schizophr Res 2018 Feb 12. Epub 2018 Feb 12.

The Psychiatric Institute, University of Illinois at Chicago, 1601 W. Taylor St., Chicago, IL, USA, 60612; Jesse Brown Veterans Affairs Medical Center, 820 South Damen Avenue (M/C 151), Chicago, IL, USA, 60612. Electronic address:

Altered immune function is an established finding in psychotic disorders such as schizophrenia and bipolar disorder with psychosis, though its role in their development and progression remains to be understood. Evidence suggests altered JAK-STAT1 pathway activity in peripheral blood cells from participants with schizophrenia compared to controls. Activation of this pathway leads to increased expression of complement component 4A (C4A), which has recently been implicated in schizophrenia. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09209964183003
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http://dx.doi.org/10.1016/j.schres.2018.01.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6087677PMC
February 2018
18 Reads

Bifactor Modeling of the Positive and Negative Syndrome Scale: Generalized Psychosis Spans Schizoaffective, Bipolar, and Schizophrenia Diagnoses.

Schizophr Bull 2018 10;44(6):1204-1216

Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA.

Objective: Common genetic variation spans schizophrenia, schizoaffective and bipolar disorders, but historically, these syndromes have been distinguished categorically. A symptom dimension shared across these syndromes, if such a general factor exists, might provide a clearer target for understanding and treating mental illnesses that share core biological bases.

Method: We tested the hypothesis that a bifactor model of the Positive and Negative Syndrome Scale (PANSS), containing 1 general factor and 5 specific factors (positive, negative, disorganized, excited, anxiety), explains the cross-diagnostic structure of symptoms better than the traditional 5-factor model, and examined the extent to which a general factor reflects the overall severity of symptoms spanning diagnoses in 5094 total patients with a diagnosis of schizophrenia, schizoaffective, and bipolar disorder. Read More

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https://academic.oup.com/schizophreniabulletin/article/44/6/
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http://dx.doi.org/10.1093/schbul/sbx163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192503PMC
October 2018
14 Reads

Patients with chronic bipolar disorder exhibit widespread increases in extracellular free water.

Bipolar Disord 2018 09 11;20(6):523-530. Epub 2017 Dec 11.

Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Objectives: Bipolar disorder (BP) is a debilitating psychiatric disease that is not well understood. Previous diffusion magnetic resonance imaging (dMRI) studies of BP patients found prominent microstructural white matter (WM) abnormalities of reduced fractional anisotropy (FA). Because FA is a nonspecific measure, relating these abnormalities to a specific pathology is difficult. Read More

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http://dx.doi.org/10.1111/bdi.12588DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420814PMC
September 2018
31 Reads

Common variants at 2q11.2, 8q21.3, and 11q13.2 are associated with major mood disorders.

Transl Psychiatry 2017 12 11;7(12):1273. Epub 2017 Dec 11.

Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China.

Bipolar disorder (BPD) and major depressive disorder (MDD) are primary major mood disorders. Recent studies suggest that they share certain psychopathological features and common risk genes, but unraveling the full genetic architecture underlying the risk of major mood disorders remains an important scientific task. The public genome-wide association study (GWAS) data sets offer the opportunity to examine this topic by utilizing large amounts of combined genetic data, which should ultimately allow a better understanding of the onset and development of these illnesses. Read More

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http://dx.doi.org/10.1038/s41398-017-0019-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802692PMC
December 2017
65 Reads

Decisional conflict in mental health care: a cross-sectional study.

Soc Psychiatry Psychiatr Epidemiol 2018 02 6;53(2):161-169. Epub 2017 Dec 6.

GGZ inGeest, A.J. Ernststraat 1187, 1081, HL, Amsterdam, The Netherlands.

Purpose: Decisional conflict refers to the degree to which patients are engaged in and feel comfortable about important clinical decisions. Until now, the concept has received little attention in mental health care. We investigate the level of decisional conflict in mental health care and whether this is influenced by socio-demographics, treatment setting, diagnoses, and locus of control. Read More

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http://dx.doi.org/10.1007/s00127-017-1467-9DOI Listing
February 2018
11 Reads

De Clérambault Syndrome, Othello Syndrome, Folie à Deux and Variants.

Front Neurol Neurosci 2018 17;42:44-50. Epub 2017 Nov 17.

Non-bizarre delusion, defined as a false belief possible although highly unlikely, is the main manifestation of delusional disorders, previously known as paranoia. Based on the predominant delusional themes, 5 main subtypes may be described - erotomanic, grandiose, jealous, persecutory, and somatic. We present here 2 main delusional disorders, the De Clérambault syndrome and the Othello syndrome, and another closely related to the previous ones - Folie à deux. Read More

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https://www.karger.com/Article/FullText/475685
Publisher Site
http://dx.doi.org/10.1159/000475685DOI Listing
July 2018
12 Reads

Association of Obsessive-Compulsive Disorder With Objective Indicators of Educational Attainment: A Nationwide Register-Based Sibling Control Study.

JAMA Psychiatry 2018 Jan;75(1):47-55

Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.

Importance: To our knowledge, the association of obsessive-compulsive disorder (OCD) and academic performance has not been objectively quantified.

Objective: To investigate the association of OCD with objectively measured educational outcomes in a nationwide cohort, adjusting for covariates and unmeasured factors shared between siblings.

Design, Setting, And Participants: This population-based birth cohort study included 2 115 554 individuals who were born in Sweden between January 1, 1976, and December 31, 1998, and followed up through December 31, 2013. Read More

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http://dx.doi.org/10.1001/jamapsychiatry.2017.3523DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833536PMC
January 2018
25 Reads

Stress-Dependent Association Between Polygenic Risk for Schizophrenia and Schizotypal Traits in Young Army Recruits.

Schizophr Bull 2018 02;44(2):338-347

Department of Psychiatry, National and Kapodistrian University of Athens School of Medicine, Eginition Hospital, Athens, Greece.

Schizotypal personality traits may increase proneness to psychosis and likely index familial vulnerability to schizophrenia (SZ), implying shared genetic determinants with SZ. Here, we sought to investigate the contribution of common genetic risk variation for SZ on self-reported schizotypy in 2 ethnically homogeneous cohorts of healthy young males during compulsory military service, enrolled in the Athens Study of Proneness and Incidence of Schizophrenia (ASPIS, N = 875) and the Learning on Genetics of Schizophrenia Spectrum study (LOGOS, N = 690). A follow-up psychometric assessment was performed in a sub-sample of the ASPIS (N = 121), 18 months later at military service completion. Read More

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http://dx.doi.org/10.1093/schbul/sbx074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814832PMC
February 2018
14 Reads

Folie à deux by Proxy in a Father, after Physical Abuse by a Mentally Ill Daughter.

Authors:
J L Tay Z Li

East Asian Arch Psychiatry 2017 Sep;27(3):121-4

Institute of Mental Health, Buangkok Green Medical Park, 10 Buangkok View, Singapore 539747.

This is the first case report in a country predominated by Chinese that describes the physical abuse of a recipient by the inducer in shared delusional disorder. The report describes a 42-year-old patient who physically abused her father until he submitted to her delusions. Subsequently and for years, both sustained persecutory delusions against their neighbours. Read More

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September 2017
7 Reads

Psychotic patients who used cannabis frequently before illness onset have higher genetic predisposition to schizophrenia than those who did not.

Psychol Med 2018 Jan 2;48(1):43-49. Epub 2017 Oct 2.

NORMENT,KG Jebsen Centre for Psychosis Research,Institute of Clinical Medicine,University of Oslo,and Division of Mental Health and Addiction,Oslo University Hospital,Oslo,Norway.

Background: Schizophrenia (SZ) and bipolar disorder (BD) are heritable, polygenic disorders with shared clinical and genetic components, suggesting a psychosis continuum. Cannabis use is a well-documented environmental risk factor in psychotic disorders. In the current study, we investigated the relationship between SZ genetic load and cannabis use before illness onset in SZ and BD spectrums. Read More

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http://dx.doi.org/10.1017/S0033291717001209DOI Listing
January 2018
4 Reads

A study in the general population about sadness to disentangle the continuum from well-being to depressive disorders.

J Affect Disord 2018 01 21;226:66-71. Epub 2017 Sep 21.

University Paris 7 Denis Diderot, Faculty of Medicine, Paris, France; Fondation FondaMental, Créteil, France; Inserm, U1144, Paris F-75006, France; AP-HP, GH Saint-Louis - Lariboisière - F. Widal, Pôle de Psychiatrie et de Médecine Addictologique, 75475 Paris cedex 10, France; Université Paris Descartes, UMR-S 1144, Paris F-75006, France.

Objective: Sadness is both a common experience in general population and one of the main criteria of major depressive disorder (MDD). We tested the hypothesis of a depressive continuum using sadness as an intermediate experience between well-being and disorder.

Methods: A French cross-sectional Mental Health survey in General Population interviewed 38,694 individuals. Read More

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http://dx.doi.org/10.1016/j.jad.2017.08.085DOI Listing
January 2018
40 Reads

A polygenic risk score analysis of psychosis endophenotypes across brain functional, structural, and cognitive domains.

Am J Med Genet B Neuropsychiatr Genet 2018 Jan 29;177(1):21-34. Epub 2017 Aug 29.

Division of Psychiatry, University College London, London, UK.

This large multi-center study investigates the relationships between genetic risk for schizophrenia and bipolar disorder, and multi-modal endophenotypes for psychosis. The sample included 4,242 individuals; 1,087 patients with psychosis, 822 unaffected first-degree relatives of patients, and 2,333 controls. Endophenotypes included the P300 event-related potential (N = 515), lateral ventricular volume (N = 798), and the cognitive measures block design (N = 3,089), digit span (N = 1,437), and the Ray Auditory Verbal Learning Task (N = 2,406). Read More

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http://dx.doi.org/10.1002/ajmg.b.32581DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5763362PMC
January 2018
78 Reads

Delusional sharing: a history focus-on and case report of folie à deux.

Riv Psichiatr 2017 Jul-Aug;52(4):168-171

Department of Medicine, Section of Psychiatry, University of Perugia, Italy.

Folie à deux (FAD) is a clinical condition that was first described by Lasègue and Falret in 19th century. They reported a rare condition where two or more people shared delusional ideas from a person to another. Nowadays a trace of this historical diagnosis and its theoretical framework, could be found on ICD-10 where FAD is translated in “Shared Psychotic Disorder”. Read More

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http://dx.doi.org/10.1708/2737.27910DOI Listing
June 2018
11 Reads

The Folie à Trois.

Authors:
T Mitin A Choudhury

Int J Radiat Oncol Biol Phys 2017 09 7;99(1). Epub 2017 Aug 7.

The Christie NHS Foundation Trust and Manchester Academic Health Sciences Centre, University of Manchester, Manchester, United Kingdom.

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http://dx.doi.org/10.1016/j.ijrobp.2017.05.046DOI Listing
September 2017
4 Reads

The Personal Antipsychotic Choice Index.

Pharmacopsychiatry 2018 May 15;51(3):89-99. Epub 2017 Aug 15.

Department Early Psychosis, Academical Medical Centre of the University of Amsterdam, Amterdam, the Netherlands.

Introduction: We present an online decision aid to involve patients with a psychotic disorder in shared decision-making concerning the selection of antipsychotic medication.

Method: Patients selected effectiveness and adverse effects criteria from the Subject's Response to Antipsychotics-34 questionnaire. Numerical data from meta-analyses, clinical trial data, receptor affinities and expert opinions were used to rank antipsychotics on each criterion. Read More

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http://dx.doi.org/10.1055/s-0043-116854DOI Listing
May 2018
16 Reads

Folie à deux and Delusional Parasitosis.

Asian J Psychiatr 2017 Aug 4;28:152-153. Epub 2017 May 4.

Mental Health Strategy, Department of Psychiatry, Flinders University, Bedford Park, Australia; SA Health, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.ajp.2017.04.027DOI Listing
August 2017
7 Reads

Seeking to understand lived experiences of personal recovery in personality disorder in community and forensic settings - a qualitative methods investigation.

BMC Psychiatry 2017 08 1;17(1):282. Epub 2017 Aug 1.

University of Manchester, Manchester, UK.

Background: Understandings of personal recovery have emerged as an alternative framework to traditional ideas of clinical progression, or symptom remission, in clinical practice. Most research in this field has focussed on the experience of individuals suffering with psychotic disorders and little research has been conducted to explore the experience of individuals with a personality disorder diagnosis, despite the high prevalence of such difficulties. The nature of the personality disorder diagnosis, together with high prevalence rates in forensic settings, renders the understanding of recovery in these contexts particularly problematic. Read More

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http://dx.doi.org/10.1186/s12888-017-1442-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5539887PMC
August 2017
7 Reads

A comparative meta-analysis of neurocognition in first-degree relatives of patients with schizophrenia and bipolar disorder.

Authors:
E Bora

Eur Psychiatry 2017 09 5;45:121-128. Epub 2017 Jul 5.

Department of psychiatry, faculty of medicine, Dokuz Eylül university, Izmir, Turkey; Melbourne neuropsychiatry centre, department of psychiatry, university of Melbourne and Melbourne health, Carlton South, 3053 Victoria, Australia. Electronic address:

Objective: Cognitive impairment is a familial and heritable aspect of major psychoses and might be a shared vulnerability marker for schizophrenia and BP. However, it is not clear whether some aspects of cognitive deficits are uniquely associated with risk for specific diagnoses.

Methods: A novel meta-analysis of cognitive functions in first-degree relatives of probands with bipolar disorder (BP-Rel) and schizophrenia (Sch-Rel) was conducted. Read More

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http://dx.doi.org/10.1016/j.eurpsy.2017.06.003DOI Listing
September 2017
3 Reads

[A typical shared psychotic disorder: about a case].

Pan Afr Med J 2017 5;27:12. Epub 2017 May 5.

Département de Pédiatrie, Cliniques Universitaires de Lubumbashi, Faculté de Médecine, Université de Lubumbashi, Lubumbashi, RDCongo.

Shared psychotic disorder is a rare entity characterized by the transmission of delusional symptoms from one patient ("inducer") to another ("induced" partner). We here report a clinical observation of atypical shared psychotic disorder involving delusion of persecution and of grandeur in a teenager induced by two subjects (grand-father and paternal uncle) with two different types of psychiatric disorders, all of which present in the same subject (third-party). The nature of the content transmitted to the third subject was the sum of the ideas of the first two subjects. Read More

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http://dx.doi.org/10.11604/pamj.2017.27.12.9481DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5511725PMC
August 2017
5 Reads

Genetic variants of increased waist circumference in psychosis.

Psychiatr Genet 2017 12;27(6):210-218

Departments of aMolecular Medicine and Surgery, Neurogenetics Unit bNeurobiology, Care Sciences and Society, Centre for Family Medicine cClinical Neuroscience dMolecular Medicine and Surgery, Endocrine and Diabetes Unit eMedicine, Cardiovascular Medicine Unit, Karolinska Institutet fCenter for Molecular Medicine, Karolinska University Hospital Solna gDepartment of Adult Psychiatry, PRIMA Barn och Vuxenpsykiatri AB hChild and Adolescent Psychiatry Research Center, Stockholm, Sweden.

Objective: We examined whether established metabolic risk genetic variants in the population confer a risk for increased waist circumference in patients with schizophrenia spectrum disorders and also an association with schizophrenia spectrum disorders irrespective of waist circumference.

Patients And Methods: We analyzed the association in (i) a case-case model in which patients with schizophrenia spectrum disorder with increased waist circumference (≥80 cm for women and ≥94 cm for men) (n=534) were compared with patients with normal waist circumference (<80 cm for women; <94 cm for men) (n=124), and in (ii) a case-control model in which schizophrenia spectrum disorder patients with increased waist circumference or irrespective of waist circumference were compared with population-derived controls (n=494) adjusted for age, sex, fasting glucose, smoking, and family history of diabetes.

Results: Genetic variants in five genes (MIA3, MRAS, P2RX7, CAMKK2, and SMAD3) were associated with increased waist circumference in patients with schizophrenia spectrum disorder (P<0. Read More

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http://dx.doi.org/10.1097/YPG.0000000000000181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5662154PMC
December 2017
29 Reads

Depressive, anxiety and hypomanic symptoms in schizophrenia may be driven by tryptophan catabolite (TRYCAT) patterning of IgA and IgM responses directed to TRYCATs.

Prog Neuropsychopharmacol Biol Psychiatry 2018 Jan 8;80(Pt C):205-216. Epub 2017 Jul 8.

Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Department of Psychiatry, Medical University of Plovdiv, Plovdiv, Bulgaria; Department of Psychiatry, Faculty of Medicine, State University of Londrina, Londrina, Brazil; Revitalis, Waalre, The Netherlands; IMPACT Strategic Research Center, Deakin University, Geelong, Australia. Electronic address:

The aim of this study was to delineate the associations between the tryptophan catabolite (TRYCAT) pathway and affective symptoms in schizophrenia. Towards this end we measured immunoglobulin (Ig)A and IgM responses to relatively noxious TRYCATs, namely quinolinic (QA), xanthurenic (XA), picolinic (PA) acid and 3-OH-kynurenine (3HK), and generally protective TRYCATs, namely anthranilic (AA) and kynurenic (KA) acid in 80 patients with schizophrenia and 40 healthy controls. The Hamilton Rating Scale for Depression (HDRS) and anxiety (HAMA), Young Mania Rating Scale (YMRS) as well as the Positive and Negative Symptoms Scale of Schizophrenia (PANSS) were measured. Read More

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http://dx.doi.org/10.1016/j.pnpbp.2017.06.033DOI Listing
January 2018
59 Reads

Neural - hormonal responses to negative affective stimuli: Impact of dysphoric mood and sex.

J Affect Disord 2017 11 28;222:88-97. Epub 2017 Jun 28.

Connors Center for Women's Health and Gender Biology, Department of Medicine, Brigham and Women's Hospital; Department of Psychiatry, Harvard Medical School (HMS), Boston, MA, USA; Departments of Psychiatry and Medicine, Harvard Medical School, Boston, MA, USA. Electronic address:

Background: Maladaptive responses to negative affective stimuli are pervasive, including clinically ill and healthy people, and men and women respond differently at neural and hormonal levels. Inspired by the Research Domain Criteria initiative, we used a transdiagnostic approach to investigate the impact of sex and dysphoric mood on neural-hormonal responses to negative affective stimuli.

Methods: Participants included 99 individuals with major depressive disorder, psychosis and healthy controls. Read More

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http://dx.doi.org/10.1016/j.jad.2017.06.050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5560420PMC
November 2017
8 Reads

Similar white matter changes in schizophrenia and bipolar disorder: A tract-based spatial statistics study.

PLoS One 2017 28;12(6):e0178089. Epub 2017 Jun 28.

Department of Neurosciences and Mental Health, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy.

Several strands of evidence reported a significant overlapping, in terms of clinical symptoms, epidemiology and treatment response, between the two major psychotic disorders-Schizophrenia (SCZ) and Bipolar Disorder (BD). Nevertheless, the shared neurobiological correlates of these two disorders are far from conclusive. This study aims toward a better understanding of possible common microstructural brain alterations in SCZ and BD. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0178089PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5489157PMC
September 2017
43 Reads

Debt Counselling for Depression in Primary Care: an adaptive randomised controlled pilot trial (DeCoDer study).

Health Technol Assess 2017 06;21(35):1-164

Institute of Translational and Stratified Medicine, Plymouth University Peninsula Schools of Medicine and Dentistry, Plymouth, UK.

Background: Depression and debt are common in the UK. Debt Counselling for Depression in Primary Care: an adaptive randomised controlled pilot trial (DeCoDer) aimed to assess the clinical effectiveness and cost-effectiveness of the addition of a primary care debt counselling advice service to usual care for patients with depression and debt. However, the study was terminated early during the internal pilot trial phase because of recruitment delays. Read More

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http://dx.doi.org/10.3310/hta21350DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5502372PMC
June 2017
43 Reads
1 Citation
5.030 Impact Factor

Childhood trauma and negative memory bias as shared risk factors for psychopathology and comorbidity in a naturalistic psychiatric patient sample.

Brain Behav 2017 06 9;7(6):e00693. Epub 2017 May 9.

Department of Psychiatry Radboud University Medical Center Nijmegen The Netherlands.

Background: Both childhood trauma and negative memory bias are associated with the onset and severity level of several psychiatric disorders, such as depression and anxiety disorders. Studies on these risk factors, however, generally use homogeneous noncomorbid samples. Hence, studies in naturalistic psychiatric samples are lacking. Read More

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http://dx.doi.org/10.1002/brb3.693DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5474701PMC
June 2017
20 Reads

Communication skills training for mental health professionals working with people with severe mental illness.

Cochrane Database Syst Rev 2017 06 13;6:CD010006. Epub 2017 Jun 13.

St George's University of London Medical School, University of Nicosia, 93 Agiou Nikolaou Street, Engomi, Nicosia, Cyprus, 2408.

Background: Research evidence suggests that both mental health professionals and people with severe mental health illness such as schizophrenia or schizoaffective disorder find it difficult to communicate with each other effectively about symptoms, treatments and their side effects so that they reach a shared understanding about diagnosis, prognosis and treatment. Effective use of communication skills in mental health interactions could be associated with increased patient satisfaction and adherence to treatment.

Objectives: To review the effectiveness of communication skills training for mental health professionals who work with people with severe mental illness. Read More

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http://dx.doi.org/10.1002/14651858.CD010006.pub2DOI Listing
June 2017
8 Reads

Working memory predicts presence of auditory verbal hallucinations in schizophrenia and bipolar disorder with psychosis.

J Clin Exp Neuropsychol 2018 02 31;40(1):84-94. Epub 2017 May 31.

a Department of Psychiatry , University of Illinois at Chicago , Chicago , IL , USA.

Objective: The recent dramatic increase in research investigating auditory verbal hallucinations (AVHs) has broadened the former narrow focus on schizophrenia to incorporate additional populations that experience these symptoms. However, an understanding of potential shared mechanisms remains elusive. Based on theories suggesting a failure of top-down cognitive control, we aimed to compare the relationship between AVHs and cognition in two categorical diagnoses of psychosis, schizophrenia and psychotic bipolar disorder. Read More

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http://dx.doi.org/10.1080/13803395.2017.1321106DOI Listing
February 2018
13 Reads