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Int Immunopharmacol 2020 Jul 1;86:106749. Epub 2020 Jul 1.

Department of Pharmacy, Wuxi People's Hospital Attached to Nanjing Medical University, Wuxi 214023, Jiangsu, China. Electronic address:

In December 2019, a novel coronavirus pneumonia (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) suddenly broke out in China and rapidly spread all over the world. Recently, a cell surface protein, known as angiotensin-converting enzyme II (ACE2), has been identified to be involved in receptor-mediated endocytosis for SARS-CoV-2 entry to the cells. Many studies have reported the clinical characteristics of COVID-19: sudden deterioration of disease around 1-2 weeks after onset; much lower level of lymphocytes, especially natural killer (NK) cells in peripheral blood; extremely high pro-inflammatory cytokines and C reactive protein (CRP). Read More

Environ Pollut 2020 Jul 2;266(Pt 1):115161. Epub 2020 Jul 2.

China CDC Key Laboratory of Environment and Population Health National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing, 100021, China; Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu, 211166, China. Electronic address:

As the number of Coronavirus Disease (2019) (COVID-19) cases increase globally, countries are taking more aggressive preventive measures against this pandemic. Transmission routes of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) include droplet and contact transmissions. There are also evidence of transmission through aerosol generating procedures (AGP) in specific circumstances and settings. Read More

Am J Infect Control 2020 Jul 6. Epub 2020 Jul 6.

University of British Columbia, School of Population and Public Health, 2206 E Mall, Vancouver, British Columbia, V6T 1Z3, Canada; Vancouver Coastal Health, 601 W Broadway, Vancouver, British Columbia, V5Z 4C2, Canada. Electronic address:

We conducted environmental sampling at long-term care facilities to determine the extent of surface contamination with SARS-CoV-2 virus. Medical equipment used throughout the facility was determined to be contaminated. Read More

Cell 2020 Jun 28. Epub 2020 Jun 28.

QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address:

The causative agent of the coronavirus disease 2019 (COVID-19) pandemic, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected millions and killed hundreds of thousands of people worldwide, highlighting an urgent need to develop antiviral therapies. Here we present a quantitative mass spectrometry-based phosphoproteomics survey of SARS-CoV-2 infection in Vero E6 cells, revealing dramatic rewiring of phosphorylation on host and viral proteins. SARS-CoV-2 infection promoted casein kinase II (CK2) and p38 MAPK activation, production of diverse cytokines, and shutdown of mitotic kinases, resulting in cell cycle arrest. Read More

Crit Rev Clin Lab Sci 2020 Jul 9:1-24. Epub 2020 Jul 9.

Department of Experimental Medicine, University of Tor Vergata, Rome, Italy.

In December 2019, an outbreak of pneumonia of unknown origin was reported in Wuhan, Hubei Province, China. Pneumonia cases were epidemiologically linked to the Huanan Seafood Wholesale Market. Inoculation of respiratory samples into human airway epithelial cells, Vero E6 and Huh7 cell lines, led to the isolation of a novel respiratory virus whose genome analysis showed it to be a novel coronavirus related to SARS-CoV, and therefore named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Read More

J Pediatric Infect Dis Soc 2020 Jul 9. Epub 2020 Jul 9.

Division of Infectious Diseases, Department of Pediatrics, Boston Children's Hospital, Boston, Massachusetts.

Most severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections in pediatric patients are mild or asymptomatic. However, infants have emerged at higher risk of hospitalization and severe outcomes in pediatric coronavirus disease 2019 (COVID-19). We report a case series of four full term neonates hospitalized with fever and found to have SARS-CoV-2 infection with a spectrum of illness severities. Read More

PLoS One 2020 9;15(7):e0235437. Epub 2020 Jul 9.

Infectious Diseases Department, Centro Hospitalar Universitário São João, Porto, Portugal.

Background: Acute respiratory distress syndrome (ARDS) is a severe complication of malaria that remains largely unstudied. We aim to describe the development of ARDS associated with severe P. falciparum malaria, its management and impact on clinical outcome. Read More

Rev Med Virol 2020 Jul 9:e2136. Epub 2020 Jul 9.

Garden OB/GYN, Mercy Medical Center, New York, New York, USA.

SARS-CoV-2 has caused a pandemic which is putting strain on the health-care system and global economy. There is much pressure to develop both preventative and curative therapies for SARS-CoV-2 as there is no evidence to support therapies to improve outcomes in patients with SARS-CoV-2. Medications that inhibit certain steps of virus life cycle that are currently used to treat other illnesses such as Malaria, Ebola, HIV and Hepatitis C are being studied for use against SARS-CoV-2. Read More

J Med Virol 2020 Jul 9. Epub 2020 Jul 9.

Department of Medicine, Texas Tech University Health Sciences Center, El Paso, Texas, USA.

Background: Respiratory failure in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection appears related to cytokine release syndrome (CRS) that often results in mechanical ventilation (MV). We investigated the role of tocilizumab (TCZ) on interleukin-6 (IL-6) trends and MV in SARS-CoV-2 patients.

Methods: In this longitudinal observational study, 112 patients were evaluated from 2/1/2020 - 5/31/2020. Read More

J Med Virol 2020 Jul 9. Epub 2020 Jul 9.

Department of Infectious Disease, Beijing YouAn Hospital, Capital Medical University, Beijing, China.

Aim: To investigate the factors associated with the duration of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA shedding in patients with coronavirus disease 2019 (COVID-19).

Methods: A retrospective cohort of COVID-19 patients admitted to a designated hospital in Beijing was analyzed to study the factors affecting the duration of viral shedding.

Results: The median duration of viral shedding was 11 days (IQR, 8-14. Read More

J Med Virol 2020 Jul 9. Epub 2020 Jul 9.

Metabolic Diseases Unit, Department of Clinical and Experimental Medicine, "Magna Graecia" University, Viale Europa, 88100, Catanzaro, Italy.

Objective: In this study, we aimed to highlight the common early-stage clinical and laboratory variables independently related to the acute phase duration in patients with uncomplicated coronavirus disease (COVID-19) pneumonia.

Methods: In hospitalized patients, the acute phase disease duration was followed using the Brescia-COVID respiratory severity scale (BCRSS). Noninvasive ventilation was administered based on clinical judgment. Read More

A A Pract 2020 Jun;14(8):e01269

From the Departments of *Anesthesiology and Critical Care †Trauma and Emergency (Anesthesiology), All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.

Tracheal stenosis is an uncommon but severe problem after long-term intubation. Here, we report a patient who came from a containment zone of coronavirus disease 2019 (COVID-19) and presented with complaints of breathlessness and cough. She was suspected to have an infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Read More

J Clin Hypertens (Greenwich) 2020 Jul 9. Epub 2020 Jul 9.

Department of Hypertension, Centre for Epidemiological Studies and Clinical Trials, The Shanghai Institute of Hypertension, Shanghai Key Laboratory of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

There are several risk factors for worse outcomes in patients with coronavirus 2019 disease (COVID-19). Patients with hypertension appear to have a poor prognosis, but there is no direct evidence that hypertension increases the risk of new infection or adverse outcomes independent of age and other risk factors. There is also concern about use of renin-angiotensin system (RAS) inhibitors due to a key role of angiotensin-converting enzyme 2 receptors in the entry of the SARS-CoV-2 virus into cells. Read More

Clin Sci (Lond) 2020 Jul 9. Epub 2020 Jul 9.

Peking University Third Hospital, Beijing, China.

Acute respiratory distress syndrome (ARDS) is a severe condition with high morbidity and mortality and few interventions. The role of sympathetic stress in the pathogenesis of ARDS has attracted recent research attention. Blockade of alpha-2- or alpha2A-adrenoceptor (α2A-AR) has been shown to attenuate lung injury induced by lipopolysaccharide in rats. Read More

Perfusion 2020 Jul 9:267659120939757. Epub 2020 Jul 9.

Division of Critical Care Medicine, Department of Pediatrics, Steven and Alexandra Cohen Children's Medical Center, Northwell Health, New Hyde Park, NY, USA.

Background: The SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) coronavirus has emerged as a highly contagious respiratory pathogen causing severe acute lung injury. Extracorporeal membrane oxygenation is a standard tool for the management of life-threatening acute respiratory distress syndrome, but the use of this resource-intensive therapy has come into question due to strained medical systems and limited proven treatments for COVID-19.

Case Summary: A 16-year-old female with obesity presented with fever, myalgias, cough, and tachypnea and was diagnosed with COVID-19. Read More

J Biomol Struct Dyn 2020 Jul 8:1-15. Epub 2020 Jul 8.

School of Chemical Sciences, SRTM University, Nanded, Maharashtra, India.

The sharp spurt in positive cases of novel coronavirus-19 (SARS-CoV-2) worldwide has created a big threat to human. In view to expedite new drug leads for COVID-19, Main Proteases (M) of novel Coronavirus (SARS-CoV-2) has emerged as a crucial target for this virus. Nitric oxide (NO) inhibits the replication cycle of SARS-CoV. Read More

J Biomol Struct Dyn 2020 Jul 8:1-13. Epub 2020 Jul 8.

Chemistry of Medicinal Plants Department, National Research Centre, El-Tahrir St, Dokki, Giza, Egypt.

In December 2019, a COVID-19 epidemic was discovered in Wuhan, China, and since has disseminated around the world impacting human health for millions. Herein, drug discovery approaches have been utilized to identify potential natural products (NPs) as Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) main protease (M) inhibitors. The MolPort database that contains over 100,000 NPs was screened and filtered using molecular docking techniques. Read More

Scand J Gastroenterol 2020 Jul 9:1-3. Epub 2020 Jul 9.

Department of Gastroenterology, Mater Misericordiae University Hospital, Dublin, Ireland.

Background: Radical changes to clinical and endoscopy practice have been rapidly introduced following the spread of severe acute respiratory syndrome coronavirus 2 (SARS-COV-2). Urgent endoscopies are, however, intended to proceed as normal with additional personal protective procedures. A perceived reduction in hospital attendances may suggest a number of urgently indicated endoscopic retrograde cholangio-pancreatographies (ERCPs) are being missed. Read More

Drug Dev Ind Pharm 2020 Jul 8:1-9. Epub 2020 Jul 8.

School of Basic Medical Science, Guangzhou University of Chinese Medicine, Guangzhou, China.

Purpose: Huashi Baidu formula (HSBDF) was developed to treat the patients with severe COVID-19 in China. The purpose of this study was to explore its active compounds and demonstrate its mechanisms against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) through network pharmacology and molecular docking.

Methods: All the components of HSBDF were retrieved from the pharmacology database of TCM system. Read More

J Cell Physiol 2020 Jul 9. Epub 2020 Jul 9.

Department of Virology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.

Since the outbreak of severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) in December 2019 in China, there has been an upsurge in the number of deaths and infected individuals throughout the world, thereby leading to the World Health Organization declaration of a pandemic. Since no specific therapy is currently available for the same, the present study was aimed to explore the SARS-CoV-2 genome for the identification of immunogenic regions using immunoinformatics approach. A series of computational tools were applied in a systematic way to identify the epitopes that could be utilized in vaccine development. Read More

Neurol Sci 2020 Jul 9. Epub 2020 Jul 9.

Division of Neurosurgery, Department of Biotechnology and Life Sciences, University of Insubria, Via Guicciardini, 9, 21100, Varese, Italy.

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the infectious agent responsible for coronavirus disease 2019 (COVID-19). Respiratory and gastrointestinal manifestations of SARS-CoV-2 are well described, less defined is the clinical neurological spectrum of COVID-19. We reported a case of COVID-19 patient with acute monophasic Guillain-Barré syndrome (GBS), and a literature review on the SARS-CoV-2 and GBS etiological correlation. Read More

Infect Dis Ther 2020 Jul 8. Epub 2020 Jul 8.

Labor Prof. Dr. G. Enders MVZ GbR, Stuttgart, Germany.

Introduction: As of 22 June 2020, Severe Acute Respiratory Syndrome (SARS)-coronavirus (CoV)-2 has infected more than 8.95 million people worldwide, causing > 468,000 deaths. The virus is transmitted through respiratory droplets and physical contact from contaminated surfaces to the mucosa. Read More

Virol Sin 2020 Jul 8. Epub 2020 Jul 8.

Center for Translational Medicine, Wuhan Jinyintan Hospital, Wuhan, 430023, China.

Virchows Arch 2020 Jul 9. Epub 2020 Jul 9.

Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova Medical School, Via A. Gabelli 61, 35121, Padova, Italy.

Since its initial recognition in December 2019, Coronavirus disease 19 (COVID-19) has quickly spread to a pandemic infectious disease. The causative agent has been recognized as a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), primarily affecting the respiratory tract. To date, no vaccines are available nor any specific treatment. Read More

Acta Neurochir (Wien) 2020 Jul 8. Epub 2020 Jul 8.

Department of Neurosurgery, Fondazione Policlinico Universitario Agostino Gemelli, Rome, Italy.

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 or Covid-19), which began as an epidemic in China and spread globally as a pandemic, has necessitated resource management to meet emergency needs of Covid-19 patients and other emergent cases. We have conducted a survey to analyze caseload and measures to adapt indications for a perception of crisis.

Methods: We constructed a questionnaire to survey a snapshot of neurosurgical activity, resources, and indications during 1 week with usual activity in December 2019 and 1 week during SARS-CoV-2 pandemic in March 2020. Read More

Eur J Cardiothorac Surg 2020 Jul 9. Epub 2020 Jul 9.

Department of Thoracic Surgery, IEO, European Institute of Oncology IRCCS, Milan, Italy.

Clin Infect Dis 2020 Jul 9. Epub 2020 Jul 9.

State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia is a newly recognized disease, and its diagnosis is primarily confirmed by routine RT-PCR detection of SARS-CoV-2. However, we report a confirmed case of SARS-CoV-2 pneumonia with routine RT-PCR negative. This case has been finally diagnosed by Nanopore sequencing combined with antibody of SARS-CoV-2. Read More

Cureus 2020 Jul 3;12(7):e8996. Epub 2020 Jul 3.

Pulmonary and Critical Care Medicine, Pulmonary Research Institute of Southeastern Michigan, Farmington Hills, USA.

No spontaneous air leak case series have been described in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) patient population thus far. We described seven spontaneous air leak cases we found in our coronavirus disease 2019 (COVID-19) positive 976-patient cohort. Five out of seven patients eventually required mechanical ventilation, and one of these patients died. Read More

Cureus 2020 Jul 1;12(7):e8956. Epub 2020 Jul 1.

Pulmonary Medicine, Rutgers Robert Wood Johnson Medical School/Saint Peter's University Hospital, New Brunswick, USA.

Coronavirus disease 2019 has rapidly enveloped the world in a pandemic after emerging in Wuhan, China, in December 2019. We describe a 49-year-old man presenting with fever, cough, dyspnea, and myalgia diagnosed with coronavirus disease 2019 along with rhabdomyolysis and acute kidney injury. The creatine phosphokinase was elevated to 23,800 U/L before trending down to normal levels. Read More

Cureus 2020 Jun 5;12(6):e8452. Epub 2020 Jun 5.

Critical Care Medicine, Cleveland Clinic, Cleveland, USA.

Coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) is the underlying cause of a global crisis that the entire world is facing. It is a highly contagious viral infection, which is why social distancing seems to be effective. Its ability to survive on various surfaces and aerosolize necessitates very meticulous precautions, including airborne isolation for severely ill patients requiring mechanical ventilation. Read More

Cureus 2020 Jun 4;12(6):e8439. Epub 2020 Jun 4.

Internal Medicine, California Institute of Behavioral Neurosciences and Psychology, Fairfield, USA.

A whole new pathogen, to which humans have virtually no pre-existing immunity, has caused fear all over the world. Severe acute respiratory syndrome coronavirus (SARS CoV-2) is one of the types of human novel-coronavirus of the family coronavirus. The nature of transmission of the virus makes it one of the most infectious pathogenic diseases that has ever existed. Read More

Cureus 2020 Jun 3;12(6):e8429. Epub 2020 Jun 3.

Internal Medicine, Abington Hospital, Jefferson Health, Abington, USA.

Acute renal failure remains a significant concern in all patients with the coronavirus disease 2019 (COVID-19) infection. Management is particularly challenging in critically ill patients requiring intensive care unit (ICU) level of care. Supportive care in the form of accurate volume correction and avoiding nephrotoxic agents are the chief cornerstone of the management of these patients. Read More

Cureus 2020 Jun 3;12(6):e8426. Epub 2020 Jun 3.

Interventional Cardiology, State University of New York (SUNY) Upstate Medical University, Syracuse, USA.

In December 2019, an outbreak of pneumonia caused by a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), occurred in Wuhan, Hubei province, China, and it has spread rapidly across the world, causing the coronavirus disease 2019 (COVID-19) pandemic. Although SARS-CoV-2 infection predominantly results in pulmonary issues, accumulating evidence suggests the increased frequency of a variety of cardiovascular complications in patients with COVID-19. Acute cardiac injury, defined as elevated cardiac troponin levels, is the most reported cardiac abnormality in COVID-19 and strongly associated with mortality. Read More

Theranostics 2020 1;10(16):7150-7162. Epub 2020 Jun 1.

National Center for Clinical Laboratories, Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, People's Republic of China.

In December 2019, a new coronavirus disease (COVID-19) outbreak occurred in Wuhan, China. Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), which is the seventh coronavirus known to infect humans, is highly contagious and has rapidly expanded worldwide since its discovery. Quantitative nucleic acid testing has become the gold standard for diagnosis and guiding clinical decisions regarding the use of antiviral therapy. Read More

Tob Induc Dis 2020 3;18:58. Epub 2020 Jul 3.

Chelsea and Westminster Hospital NHS Foundation Trust, London, United Kingdom.

Introduction: There has been significant speculation regarding the association between the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) pathogen, coronavirus disease (COVID-19) and smoking. We provide an overview of the available literature regarding the association between smoking, risk of SARS-CoV-2 infection, and risk of severe COVID-19 and poor clinical outcomes, with the aim of informing public health policy and practice, particularly in England.

Methods: Publications were identified utilising a systematic search approach on PUBMED and Google Scholar. Read More

Saudi Pharm J 2020 Jul 22;28(7):898-902. Epub 2020 May 22.

Regional Drug Information and Pharmacovigilance Center, Ministry of Health, Tabuk, Saudi Arabia.

Late in 2019, several cases of infection with a new strain of coronavirus were reported in China. This new strain was later officially named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by the World Health Organization (WHO). This new virus (SARS-CoV2-) mainly affects the respiratory system and causes coronavirus disease 2019 (COVID-19). Read More

Saudi Pharm J 2020 Jul 18;28(7):888-897. Epub 2020 Jun 18.

Department of Pharmacognosy, College of Pharmacy, King Saud University, P. O. Box 22452, Riyadh 11495, Saudi Arabia.

Now nCOVID-19 has a foothold in many countries, and the threat of a pandemic situation has risen. Recently a novel coronavirus (nCOVID-19) has first emerged in China, causing multiple symptoms in humans and closely related to those caused by SARS (Severe Acute Respiratory Syndrome) and MERS (Middle East Respiratory Syndrome). The nCOVID-19 has reported in Wuhan city of China has recently infected over six million people and at least 0. Read More

Indian J Clin Biochem 2020 Jul 10;35(3):274-284. Epub 2020 Jun 10.

Department of Biochemistry, MM Institute of Medical Sciences and Research, Mullana, Ambala, 133207 Haryana India.

As the time for finding a definitive and safe cure as a vaccine for novel Corona Virus Disease 2019 (Covid-19) is still far, there is need to study in depth about the other potential drugs, which can save millions of lives due to Covid-19 pandemic. Right at the center of the debate is the use of drug "Hydroxychloroquine" as a prophylaxis as well as a treatment strategy against Covid-19 in conjunction with azithromycin. In this review, we will study the cellular and molecular aspects of hydroxychloroquine, which had driven its use in Covid-19 patients, as well as its chemistry and pharmacokinetics along with clinical trials going on worldwide using hydroxychloroquine against Covid-19. Read More

Indian J Clin Biochem 2020 Jul 6;35(3):260-273. Epub 2020 Jun 6.

Department of Biochemistry, All India Institute of Medical Sciences Jodhpur, Jodhpur, India.

The novel Coronavirus Disease 2019 (COVID-19), that began in Wuhan Province, China was labelled as an International Public Health Emergency on January 30, 2020 and later was declared a pandemic by the World Health Organisation (WHO) on March 11, 2020. The causative agent, SARS-CoV-2 was the third coronavirus responsible for causing major disease outbreaks in human population after Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS) caused by SARS-CoV and MERS-CoV respectively. The patients of COVID-19 present with a clinical feature resembling mild form of viral pneumonia which in certain cases progress to a severe form characterised by adult respiratory distress syndrome (ARDS) and/or multiorgan failure leading to death. Read More

Nat Rev Neurol 2020 Jul 8. Epub 2020 Jul 8.

Department of Neurology with Institute of Translational Neurology, University of Muenster, Muenster, Germany.

The coronavirus disease 2019 (COVID-19) pandemic is concerning for patients with neuroimmunological diseases who are receiving immunotherapy. Uncertainty remains about whether immunotherapies increase the risk of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or increase the risk of severe disease and death upon infection. National and international societies have developed guidelines and statements, but consensus does not exist in several areas. Read More

Cell Death Dis 2020 Jul 8;11(7):516. Epub 2020 Jul 8.

Special Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi, India.

Coronavirus disease 2019 (COVID-19) is a severe acute respiratory syndrome caused by Coronavirus 2 (SARS-CoV-2). In the light of its rapid global spreading, on 11 March 2020, the World Health Organization has declared it a pandemic. Interestingly, the global spreading of the disease is not uniform, but has so far left some countries relatively less affected. Read More

Cell Death Dis 2020 Jul 8;11(7):512. Epub 2020 Jul 8.

Department of Rheumatology and Immunology, The Third Affiliated Hospital of Southern Medical University, No. 183, Zhongshan Avenue West, Tianhe District, Guangzhou, 510630, Guangdong, China.

The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first reported in December 2019. As similar cases rapidly emerged around the world, the World Health Organization (WHO) declared a public health emergency of international concern on January 30, 2020 and pronounced the rapidly spreading coronavirus outbreak as a pandemic on March 11, 2020. The virus has reached almost all countries of the globe. Read More

Tohoku J Exp Med 2020 ;251(3):175-181

Department of Pathology, Lake Erie College of Osteopathic Medicine.

The novel coronavirus disease 2019 (COVID-19) is now officially declared as a pandemic by the World Health Organization (WHO), and most parts of the world are taking drastic measures to restrict human movements to contain the infection. Millions around the world are wondering, if there is anything that could be done, other than maintaining high personal hygiene, and be vigilant of the symptoms, to reduce the spread of the disease and chances of getting infected, or at least to lessen the burden of the disease, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The National and International health agencies, including the National Institutes of Health (NIH), the Centers for Disease Control and Prevention (CDC), and the WHO have provided clear guidelines for both preventive and treatment suggestions. Read More

Neurology 2020 Jul 8. Epub 2020 Jul 8.

Department of Neurology, Hospital Universitario 12 de Octubre, Madrid, Spain.

Objective: To report a case of a patient infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) who acutely developed a hypokinetic-rigid syndrome.

Methods: Patient data were obtained from medical records from the "Hospital Universitario 12 de Octubre" in Madrid, Spain. [I]-ioflupane dopamine transporter single-photon emission CT (DaT-SPECT) images were acquired 4 hours after a single dose of 185 MBq of I-FP-CIT. Read More

Proc Natl Acad Sci U S A 2020 Jul 8. Epub 2020 Jul 8.

Center for Drug Discovery, Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX 77030

DNA-encoded chemical libraries are collections of compounds individually coupled to unique DNA tags serving as amplifiable identification barcodes. By bridging split-and-pool combinatorial synthesis with the ligation of unique encoding DNA oligomers, million- to billion-member libraries can be synthesized for use in hundreds of healthcare target screens. Although structural diversity and desirable molecular property ranges generally guide DNA-encoded chemical library design, recent reports have highlighted the utility of focused DNA-encoded chemical libraries that are structurally biased for a class of protein targets. Read More

Gut 2020 Jul 8. Epub 2020 Jul 8.

Department of Medicine and Therapeutics, Medical Data Analytic Centre (MDAC), Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, Hong Kong

Objective: Data on serial liver biochemistries of patients infected by different human coronaviruses (HCoVs) are lacking. The impact of liver injury on adverse clinical outcomes in coronavirus disease 2019 (COVID-19) patients remains unclear.

Design: This was a retrospective cohort study using data from a territory-wide database in Hong Kong. Read More

BMJ Case Rep 2020 Jul 7;13(7). Epub 2020 Jul 7.

Loch Lomond Surgery, 75 Bank Street, Alexandria, Scotland

This is a case of a patient who presented with an urticarial rash 48 hours before developing symptoms of fever and a continuous cough. She subsequently developed angioedema of her lips and hands before testing positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Urticarial rashes occurring 48 hours before other symptoms of COVID-19 infection have been documented. Read More

Int J Gynecol Cancer 2020 Jul 7. Epub 2020 Jul 7.

Gynecology, MD Anderson Cancer Center Madrid, Madrid, Spain.

Objectives: While numerous medical facilities have been forced to suspend oncological surgery due to system overload, debate has emerged on using non-surgical options on cancer cases during the pandemic. The goal of our study was to analyze, in a retrospective cohort study, the results of gynecological cancer surgery and evaluate postoperative complications in a single center in one of the most affected areas in Europe.

Methods: We retrospectively analyzed the records of patients who were referred between March 2020 and May 2020 for primary surgical treatment of breast, endometrial, ovarian, cervical, or vulvar cancer. Read More

BMJ Open 2020 Jul 8;10(7):e039519. Epub 2020 Jul 8.

Department of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China

Introduction: The rapid worldwide spread of COVID-19 has caused a global health crisis. To date, symptomatic supportive care has been the most common treatment. It has been reported that the mechanism of COVID-19 is related to cytokine storms and subsequent immunogenic damage, especially damage to the endothelium and alveolar membrane. Read More