11,995 results match your criteria Severe Acute Respiratory Syndrome SARS


Kaempferol reduces K63-linked polyubiquitination to inhibit nuclear factor-κB and inflammatory responses in acute lung injury in mice.

Toxicol Lett 2019 Feb 12. Epub 2019 Feb 12.

Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China; The Second Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China. Electronic address:

Acute lung injury (ALI) and its severe form, acute respiratory distress syndrome (ARDS), pose a major clinical challenge. The major driving force in this syndrome is pulmonary inflammation. Recent studies have shown that the naturally occurring flavonoid kaempferol (KPF) reduces endotoxin-induced inflammatory responses in mice. Read More

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http://dx.doi.org/10.1016/j.toxlet.2019.02.005DOI Listing
February 2019

Distinct Metabolic Endotype Mirroring Acute Respiratory Distress Syndrome (ARDS) Subphenotype and its Heterogeneous Biology.

Sci Rep 2019 Feb 14;9(1):2108. Epub 2019 Feb 14.

Centre of Biomedical Research, SGPGIMS Campus, Raebarelly Road, Lucknow, 226014, India.

Predisposing aetiologies in Acute Respiratory Distress Syndrome (ARDS), perpetuates to heterogeneous clinical course hampering therapeutic response. Therefore, physiological variables need to be identified by stratifying ARDS subphenotypes and endotype, to target ARDS heterogeneity. The present study is stimulated by the fact that the ARDS heterogeneity arises from diverse pathophysiological changes leading to distinct ARDS endotypes characterized by perturbed biological mechanism which can be exploited in terms of metabolic profile by metabolomics. Read More

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http://dx.doi.org/10.1038/s41598-019-39017-4DOI Listing
February 2019

Retrospective study of pneumonia due to Panton-Valentine leukocidin-producing Staphylococcus aureus in Reunion.

Med Mal Infect 2019 Feb 11. Epub 2019 Feb 11.

Centre René Labusquière, (Institut de Médecine tropicale), Université Victor Segalen, 33000 Bordeaux, France; Service de réanimation polyvalente, centre hospitalier universitaire, site Felix Guyon, allée des Topazes, CS11021, 97400 Saint-Denis, Reunion.

Objective: Panton-Valentine leukocidin-producing Staphylococcus aureus necrotizing pneumonia is an unusual cause of community-acquired pneumonia, although associated with a high case fatality. This infection mainly affects young individuals, without any history, and is most often preceded by flu-like symptoms.

Method: We focused on patients presenting with Staphylococcus aureus necrotizing pneumonia in Reunion (Indian Ocean) admitted to the emergency department. Read More

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http://dx.doi.org/10.1016/j.medmal.2019.01.010DOI Listing
February 2019

Minimal Change in Cardiac Index With Increasing PEEP in Pediatric Acute Respiratory Distress Syndrome.

Front Pediatr 2019 29;7. Epub 2019 Jan 29.

Department of Anesthesiology Critical Care Medicine, Children's Hospital Los Angeles, Keck School of Medicine of University of Southern California, Los Angeles, CA, United States.

To determine if increasing positive end expiratory pressure (PEEP) leads to a change in cardiac index in children with Pediatric Acute Respiratory Distress Syndrome ranging from mild to severe. Prospective interventional study. Multidisciplinary Pediatric Intensive Care Unit in a University teaching hospital. Read More

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https://www.frontiersin.org/article/10.3389/fped.2019.00009/
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http://dx.doi.org/10.3389/fped.2019.00009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361833PMC
January 2019
1 Read

Severe Acute Respiratory Syndrome Coronavirus Viroporin 3a Activates the NLRP3 Inflammasome.

Front Microbiol 2019 29;10:50. Epub 2019 Jan 29.

Division of Viral Infection, Department of Infectious Disease Control, International Research Center for Infectious Diseases, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.

Nod-like receptor family, pyrin domain-containing 3 (NLRP3) regulates the secretion of proinflammatory cytokines interleukin 1 beta (IL-1β) and IL-18. We previously showed that influenza virus M2 or encephalomyocarditis virus (EMCV) 2B proteins stimulate IL-1β secretion following activation of the NLRP3 inflammasome. However, the mechanism by which severe acute respiratory syndrome coronavirus (SARS-CoV) activates the NLRP3 inflammasome remains unknown. Read More

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http://dx.doi.org/10.3389/fmicb.2019.00050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361828PMC
January 2019
3.941 Impact Factor

PES Pathogens in Severe Community-Acquired Pneumonia.

Microorganisms 2019 Feb 12;7(2). Epub 2019 Feb 12.

Department of Pneumology, Hospital Clinic of Barcelona-Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona (UB)-SGR 911-Ciber de Enfermedades Respiratorias (Ciberes), 08036 Barcelona, Spain.

Worldwide, there is growing concern about the burden of pneumonia. Severe community-acquired pneumonia (CAP) is frequently complicated by pulmonary and extra-pulmonary complications, including sepsis, septic shock, acute respiratory distress syndrome, and acute cardiac events, resulting in significantly increased intensive care admission rates and mortality rates. (Pneumococcus) remains the most common causative pathogen in CAP. Read More

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http://www.mdpi.com/2076-2607/7/2/49
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http://dx.doi.org/10.3390/microorganisms7020049DOI Listing
February 2019
1 Read

MicroRNA‑223 attenuates LPS‑induced inflammation in an acute lung injury model via the NLRP3 inflammasome and TLR4/NF‑κB signaling pathway via RHOB.

Int J Mol Med 2019 Jan 23. Epub 2019 Jan 23.

Department of Anesthesiology, Liaocheng People's Hospital, Liaocheng, Shandong 252000, P.R. China.

Acute lung injury (ALI) and the more severe acute respiratory distress syndrome are common and complex inflammatory lung diseases. MicroRNAs (miRs) have emerged as novel gene regulatory molecules, serving a crucial role in a variety of complex diseases, including ALI. In the present study, the anti‑inflammatory action of miR‑223 on inflammation in ALI was demonstrated and the possible mechanism was further examined. Read More

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http://www.spandidos-publications.com/10.3892/ijmm.2019.4075
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http://dx.doi.org/10.3892/ijmm.2019.4075DOI Listing
January 2019
2 Reads

Prognostic values of the Berlin definition criteria, blood lactate level, and fibroproliferative changes on high-resolution computed tomography in ARDS patients.

BMC Pulm Med 2019 Feb 11;19(1):37. Epub 2019 Feb 11.

Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, 160-8582, Japan.

Background: In the Berlin definition, acute respiratory distress syndrome (ARDS) is stratified into three stages according to oxygenation severity at the onset. The relevance between ARDS severity and prognosis varies among published reports and has not been verified, especially in Asian patients.

Methods: In this study, we examined the associations between the Berlin definition criteria and prognosis and clinical parameters, including high-resolution computed tomography (HRCT) scores of fibroproliferative changes of the lungs. Read More

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http://dx.doi.org/10.1186/s12890-019-0803-0DOI Listing
February 2019

Effects of Stepwise Lung Recruitment Maneuvers in Patients with Early Acute Respiratory Distress Syndrome: A Prospective, Randomized, Controlled Trial.

J Clin Med 2019 Feb 10;8(2). Epub 2019 Feb 10.

School of Medicine, College of Medicine, Fu Jen Catholic University, Xinzhuang Dist., New Taipei City 24205, Taiwan (R.O.C).

Since the clinical benefit of lung recruitment maneuvers (LRMs) is still conflicting, we performed this prospective, randomized, controlled study to investigate whether LRMs should be used in the routine management of acute respiratory distress syndrome (ARDS). This trial was conducted in four intensive care units (ICUs) to compare application of a modified stepwise LRMs with solely lung-protective ventilation in patients with moderate to severe ARDS within 72 h from the onset. The primary outcome was 28-day mortality, and the secondary outcomes were ventilator-free days and ICU-free days. Read More

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http://www.mdpi.com/2077-0383/8/2/231
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http://dx.doi.org/10.3390/jcm8020231DOI Listing
February 2019
3 Reads

Acute Manifestations of Neuromuscular Disease.

Semin Neurol 2019 Feb 11;39(1):115-124. Epub 2019 Feb 11.

Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.

Neuromuscular emergencies may be defined as disorders or exacerbation of diseases of the peripheral nervous system that are rapidly progressive and potentially life-threatening. Such disorders can affect any level of the peripheral nervous system, from the muscle to the anterior horn cell. While their clinical manifestations may vary, severe morbidity and mortality is most frequently the result of neuromuscular respiratory failure. Read More

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http://dx.doi.org/10.1055/s-0038-1676838DOI Listing
February 2019
1 Read

Life-Threatening Complications among Women with Severe Ovarian Hyperstimulation Syndrome.

Am J Obstet Gynecol 2019 Feb 8. Epub 2019 Feb 8.

Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Columbia University Medical Center, 5 Columbus Circle, PH, New York, NY 10019.

Background: Ovarian hyperstimulation syndrome (OHSS) is a potentially life-threatening clinical condition.

Objective: The objective of this study was to evaluate risk factors for life-threatening complications for patients with severe OHSS in a United States nationwide sample.

Materials And Methods: OHSS admissions from 2002-2011 from the Nationwide Inpatient Sample (NIS) were included in this study. Read More

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http://dx.doi.org/10.1016/j.ajog.2019.02.009DOI Listing
February 2019
1 Read

Mapping mononuclear phagocytes in blood, lungs, and lymph nodes of sarcoidosis patients.

J Leukoc Biol 2019 Feb 11. Epub 2019 Feb 11.

Division of Immunology and Allergy, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

Sarcoidosis is a T-cell driven inflammatory disease characterized by granuloma formation. Mononuclear phagocytes (MNPs)-macrophages, monocytes, and dendritic cells (DCs)-are likely critical in sarcoidosis as they initiate and maintain T cell activation and contribute to granuloma formation by cytokine production. Granulomas manifest primarily in lungs and lung-draining lymph nodes (LLNs) but these compartments are less studied compared to blood and bronchoalveolar lavage (BAL). Read More

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http://doi.wiley.com/10.1002/JLB.5A0718-280RR
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http://dx.doi.org/10.1002/JLB.5A0718-280RRDOI Listing
February 2019
3 Reads

Geographical structure of bat SARS-related coronaviruses.

Infect Genet Evol 2019 Feb 6;69:224-229. Epub 2019 Feb 6.

CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China. Electronic address:

Bats are the natural reservoirs of severe acute respiratory syndrome coronavirus (SARS-CoV) which caused the outbreak of human SARS in 2002-2003. We introduce the genetic diversity of SARS-related coronaviruses (SARSr-CoVs) discovered in bats and provide insights on the bat origin of human SARS. We also analyze the viral geographical structure that may improve our understanding of the evolution of bat SARSr-CoVs. Read More

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http://dx.doi.org/10.1016/j.meegid.2019.02.001DOI Listing
February 2019
1 Read

HIPK1 Interference Attenuates Inflammation and Oxidative Stress of Acute Lung Injury via Autophagy.

Med Sci Monit 2019 Jan 29;25:827-835. Epub 2019 Jan 29.

Department of Obstetrics, Qingdao Municipal Hospital of Shandong Province, Qingdao, Shandong, China (mainland).

BACKGROUND Acute respiratory distress syndrome (ARDS), which is characterized by severe hypoxemia (PaO2/FIO2 ≤300 mmHg), is usually companied by uncontrolled inflammation, oxidative injury, and the damage to the alveolar-capillary barrier. Severe ARDS is usually companied with acute lung injury that worsen the patients' condition. HIPK1 is a modulator of homeodomain-containing transcription factors and regulates multiple cellular biological process associated with inflammation and anti-stress responses. Read More

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http://dx.doi.org/10.12659/MSM.912507DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362758PMC
January 2019
2 Reads

Recent Advances in Pathology: The 2019 Annual Review Issue of the Journal of Pathology.

J Pathol 2019 Feb 8. Epub 2019 Feb 8.

RECAMO, Masaryk Memorial Cancer Institute, Brno, Czech Republic.

In this Annual Review Issue of The Journal of Pathology, we present 15 invited reviews on topical aspects of pathology, ranging from the impacts of the microbiome in human disease through mechanisms of cell death and autophagy to recent advances in immunity and the uses of genomics for understanding, classifying and treating human cancers. Each of the reviews is authored by experts in their fields and our intention is to provide comprehensive updates in specific areas of pathology in which there has been considerable recent progress. Read More

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http://doi.wiley.com/10.1002/path.5255
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http://dx.doi.org/10.1002/path.5255DOI Listing
February 2019
4 Reads

Platelets inhibit apoptotic lung epithelial cell death and protect mice against infection-induced lung injury.

Blood Adv 2019 Feb;3(3):432-445

Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA.

Thrombocytopenia is associated with worse outcomes in patients with acute respiratory distress syndrome, which is most commonly caused by infection and marked by alveolar-capillary barrier disruption. However, the mechanisms by which platelets protect the lung alveolar-capillary barrier during infectious injury remain unclear. We found that natively thrombocytopenic mice deficient in the thrombopoietin receptor sustain severe lung injury marked by alveolar barrier disruption and hemorrhagic pneumonia with early mortality following acute intrapulmonary (PA) infection; barrier disruption was attenuated by platelet reconstitution. Read More

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http://dx.doi.org/10.1182/bloodadvances.2018026286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373758PMC
February 2019
2 Reads

Successful extracorporeal membrane oxygenation support for severe acute diquat and glyphosate poisoning: A case report.

Medicine (Baltimore) 2019 Feb;98(6):e14414

Department of Critical Care Medicine, Quzhou People's Hospital, Quzhou.

Rationale: Because of the lack of an antidote or effective treatment, patients with severe acute diquat and glyphosate poisoning always died within a few hours. Extracorporeal membrane pulmonary oxygenation (ECMO), as an artificial heart-lung supporting system, can be applied to support lung that is expected to recover from reversible pathological damage. However, to our knowledge, the application of ECMO for patients with diquat and glyphosate poisoning has not been reported. Read More

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http://dx.doi.org/10.1097/MD.0000000000014414DOI Listing
February 2019
1 Read

Severe acute respiratory syndrome and other emerging severe respiratory viral infections.

Respirology 2019 Feb 7. Epub 2019 Feb 7.

School of Public Health, University of Hong Kong, Hong Kong.

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http://dx.doi.org/10.1111/resp.13501DOI Listing
February 2019
1 Read

Severe thoracic trauma caused left pneumonectomy complicated by right traumatic wet lung, reversed by extracorporeal membrane oxygenation support-a case report.

BMC Pulm Med 2019 Feb 6;19(1):30. Epub 2019 Feb 6.

Critical Care Medicine Department of The First People's Hospital of Foshan, Lingnan Avenue North 81, Shiwan, Chancheng, Foshan, 528000, China.

Background: Double lumen intubation and one-lung ventilation should be applied without delay in cases of traumatic main bronchial rupture. In most cases, when the patients' vital signs have been stabilized, the repair can be performed. However, when one-lung ventilation is complicated by traumatic wet lung, the mortality rate is likely to be much higher. Read More

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http://dx.doi.org/10.1186/s12890-019-0790-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366044PMC
February 2019
1 Read

Mechanical Ventilation and Extracorporeal Membrane Oxygena tion in Acute Respiratory Insufficiency.

Dtsch Arztebl Int 2018 12;115(50):840-847

Board of directors, Ulm University Hospital

Background: Mechanical ventilation is life-saving for patients with acute respiratory insufficiency. In a German prevalence study, 13.6% of patients in intensive care units received mechanical ventilation for more than 12 hours; 20% of these patients received mechanical ventilation as treatment for acute respiratory distress syndrome (ARDS). Read More

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http://dx.doi.org/10.3238/arztebl.2018.0840DOI Listing
December 2018
2 Reads

Impact of spontaneous breathing during mechanical ventilation in acute respiratory distress syndrome.

Curr Opin Crit Care 2019 Jan 31. Epub 2019 Jan 31.

Department of Anesthesiology and Intensive Care Medicine, Osaka University Graduate School of Medicine, Suita, Japan.

Purpose Of Review: Facilitating spontaneous breathing has been traditionally recommended during mechanical ventilation in acute respiratory distress syndrome (ARDS). However, early, short-term use of neuromuscular blockade appears to improve survival, and spontaneous effort has been shown to potentiate lung injury in animal and clinical studies. The purpose of this review is to describe the beneficial and deleterious effects of spontaneous breathing in ARDS, explain potential mechanisms for harm, and provide contemporary suggestions for clinical management. Read More

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http://dx.doi.org/10.1097/MCC.0000000000000597DOI Listing
January 2019
8 Reads

Tension pneumoperitoneum: Case report of a rare form of acute abdominal compartment syndrome.

Int J Surg Case Rep 2019 Jan 29;55:112-116. Epub 2019 Jan 29.

Department of Medicine, Universidad de Los Andes, Bogotá, Colombia.

Introduction: Tension pneumoperitoneum is a severe and rare form of pneumoperitoneum with concomitant hemodynamic instability and respiratory failure. It is a variant of abdominal compartment syndrome (ACS) causing an abrupt increase in intra-abdominal pressure.

Presentation Of Case: We present a case of pneumoperitoneum, after an endoscopic mucosal resection with the development of ACS. Read More

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http://dx.doi.org/10.1016/j.ijscr.2019.01.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360270PMC
January 2019
1 Read

Gemykibivirus genome in lower respiratory tract of elderly woman with unexplained acute respiratory distress syndrome.

Clin Infect Dis 2019 Feb 2. Epub 2019 Feb 2.

The Joint Center for Infection and Immunity: a. Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou, China; b. Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China.

We identified, for the first time, the presence of small circular single stranded Gemykibivirus (GkV) genome from the respiratory tract of an elderly woman with severe acute respiratory distress syndrome using metagenomics analysis. Our results suggest that further studies on whether GkVs infect humans and cause respiratory disease are needed. Read More

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http://dx.doi.org/10.1093/cid/ciz072DOI Listing
February 2019
1 Read

Unexpected Receptor Functional Mimicry Elucidates Activation of Coronavirus Fusion.

Cell 2019 Jan 23. Epub 2019 Jan 23.

Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA. Electronic address:

Recent outbreaks of severe acute respiratory syndrome and Middle East respiratory syndrome, along with the threat of a future coronavirus-mediated pandemic, underscore the importance of finding ways to combat these viruses. The trimeric spike transmembrane glycoprotein S mediates entry into host cells and is the major target of neutralizing antibodies. To understand the humoral immune response elicited upon natural infections with coronaviruses, we structurally characterized the SARS-CoV and MERS-CoV S glycoproteins in complex with neutralizing antibodies isolated from human survivors. Read More

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http://dx.doi.org/10.1016/j.cell.2018.12.028DOI Listing
January 2019
1 Read

Omega-3 polyunsaturated fatty acids in critically ill patients with acute respiratory distress syndrome: A systematic review and meta-analysis.

Nutrition 2018 Nov 5;61:84-92. Epub 2018 Nov 5.

Department of Critical Care, Intensive Care Unit, University Hospital, Faculty of Medicine, UDELAR, Montevideo, Uruguay.

Objective: Acute respiratory distress syndrome (ARDS) is characterized by an acute inflammatory response in the lung parenchyma leading to severe hypoxemia. Because of its anti-inflammatory and immunomodulatory properties, omega-3 polyunsaturated fatty acids (ω-3 PUFA) have been administered to ARDS patients, mostly by the enteral route, as immune-enhancing diets with eicosapentaenoic acid, γ-linolenic acid, and antioxidants. However, clinical benefits of ω-3 PUFAs in ARDS patients remain unclear because clinical trials have found conflicting results. Read More

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http://dx.doi.org/10.1016/j.nut.2018.10.026DOI Listing
November 2018
1 Read

Macrolides in Critically Ill Patients with Middle East Respiratory Syndrome.

Int J Infect Dis 2019 Jan 25. Epub 2019 Jan 25.

International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC), Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia School of Medicine, Charlottesville, Virginia. Electronic address:

Objectives: Macrolides have been reported to be associated with improved outcomes in patients with viral pneumonia related to influenza and other viruses, possibly because of their immune-modulatory effects. Macrolides have frequently been used in patients with Middle East Respiratory Syndrome (MERS). This study investigated the association of macrolides with 90-day mortality and MERS coronavirus (CoV) RNA clearance in critically ill patients with MERS. Read More

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http://dx.doi.org/10.1016/j.ijid.2019.01.041DOI Listing
January 2019
4 Reads
2.330 Impact Factor

Red blood cell distribution width is an independent risk factor in the prediction of acute respiratory distress syndrome after severe burns.

Burns 2019 Jan 24. Epub 2019 Jan 24.

Department of Burns, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province 230022, PR China. Electronic address:

Background: The occurrence of acute respiratory distress syndrome (ARDS) significantly increases the mortality and morbidity of major burns; there are few laboratory markers that predict the development of ARDS in severe burns. This study was to investigate the relationship between complete blood count (CBC) parameters and the incidence of ARDS in severe burn patients.

Methods: An eight-year retrospective study was performed on 610 severe burn patients who were admitted to the First Affiliated Hospital of Anhui Medical University and Rui Jin Hospital of Shanghai Jiao Tong University from January 2008 to December 2015. Read More

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http://dx.doi.org/10.1016/j.burns.2019.01.006DOI Listing
January 2019
1 Read

From the Pharynx to the Abdomen: A Case of Primary Peritonitis.

Acta Med Port 2018 Dec 28;31(12):774-777. Epub 2018 Dec 28.

Serviço de Medicina Intensiva 1. Centro Hospitalar Universitário do Algarve. Unidade de Faro. Faro. Portugal.

Primary peritonitis usually occurs in patients with comorbidities previously diagnosed with ascites. However, a primary peritoneal infection in previously healthy patients may also ensue. There has been an increase in reported cases of primary peritonitis due to Streptococcus pyogenes affecting mostly women. Read More

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https://actamedicaportuguesa.com/revista/index.php/amp/artic
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http://dx.doi.org/10.20344/amp.10053DOI Listing
December 2018
4 Reads

Bovine-like coronaviruses in domestic and wild ruminants.

Anim Health Res Rev 2018 Dec;19(2):113-124

Department of Virology, Faculty of Veterinary Medicine,Cairo University,11221 Giza,Egypt.

Coronaviruses (CoVs) produce a wide spectrum of disease syndromes in different mammalian and avian host species. These viruses are well-recognized for their ability to change tissue tropism, to hurdle the interspecies barriers and to adapt ecological variations. It is predicted that the inherent genetic diversity of CoVs caused by accumulation of point mutations and high frequency of homologous recombination is the principal determinant of these competences. Read More

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http://dx.doi.org/10.1017/S1466252318000117DOI Listing
December 2018
10 Reads

Customs officers in relation to viral infections, tuberculosis, psittacosis and environmental health risk.

Exp Ther Med 2019 Feb 10;17(2):1149-1153. Epub 2018 Dec 10.

Department of Virology, School of Medicine, University of Crete, 71110 Heraklion, Greece.

Customs Service is a financial authority responsible for controlling the flow of importation and exportation goods in each country and for collecting the relevant taxes. Customs officers are considered as 'high-demand' and 'high-responsibility' governmental officials, which constitute members of multidisciplinary teams at the local, as well as international level and collaborate with different authorities, including medical officers. Despite limited data in the medical literature, customs officers are considered as a 'high-risk' occupational group for infections and environmental health risk. Read More

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http://dx.doi.org/10.3892/etm.2018.7077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327673PMC
February 2019
2 Reads

Neutrophil Extracellular Traps Are Elevated in Patients with Pneumonia-related Acute Respiratory Distress Syndrome.

Anesthesiology 2019 Jan 22. Epub 2019 Jan 22.

From the Medical Intensive Care Unit, DHU A-TVB, Hôpitaux Universitaires Henri Mondor, Assistance Publique-Hôpitaux de Paris, Créteil Cedex 94010, France (I.B., G.C., K.R., A.M.D., N.d.P.) Groupe de Recherche Clinique CARMAS, Faculté de Médecine de Créteil, Université Paris Est Créteil, Créteil Cedex 94010, France (I.B., G.C., K.R., A.M.D., N.d.P.) Immunology Laboratory « Autoimmunité et Hypersensibilités, » Hôpital Bichat, Assistance Publique-Hôpitaux de Paris, Paris, France (L.d.C., V.G., S.C.-M.) Pulmonology Unit, Medical Intensive Care Unit, DHU A-TVB, Hôpitaux Universitaires Henri Mondor, Assistance Publique-Hôpitaux de Paris, Créteil Cedex 94010, France (F.S., B.M.) Immunology Laboratory, Hôpitaux Universitaires Henri Mondor, Assistance Publique-Hôpitaux de Paris, Créteil Cedex 94010, France (S.H., M.S., A.B.-F.).

What We Already Know About This Topic: Neutrophil extracellular traps are increasingly recognized as pathogenic in acute injury, but their role in sepsis-related acute respiratory distress syndrome is unknown WHAT THIS ARTICLE TELLS US THAT IS NEW:: In 35 patients with acute respiratory distress syndrome secondary to pneumonia, neutrophil extracellular traps were elevated in the blood and bronchoalveolar fluid, and associated with interleukin-8 and neutrophil levels; however, higher (vs. lower) levels of neutrophil extracellular traps were not associated with mortality or duration of mechanical ventilation BACKGROUND:: Neutrophil extracellular traps have been associated with tissue damage. Whether these are involved in the pathogenesis of human acute respiratory distress syndrome (ARDS) and could be a potential therapeutic target is unknown. Read More

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http://dx.doi.org/10.1097/ALN.0000000000002619DOI Listing
January 2019
5 Reads

What Have We Learned About Middle East Respiratory Syndrome Coronavirus Emergence in Humans? A Systematic Literature Review.

Vector Borne Zoonotic Dis 2019 Jan 24. Epub 2019 Jan 24.

1 Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York.

Background: Middle East respiratory syndrome coronavirus (MERS-CoV) was first identified in humans in 2012. A systematic literature review was conducted to synthesize current knowledge and identify critical knowledge gaps.

Materials And Methods: We conducted a systematic review on MERS-CoV using PRISMA guidelines. Read More

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https://www.liebertpub.com/doi/10.1089/vbz.2017.2191
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http://dx.doi.org/10.1089/vbz.2017.2191DOI Listing
January 2019
4 Reads

Biomarkers for Acute Respiratory Distress syndrome and prospects for personalised medicine.

J Inflamm (Lond) 2019 15;16. Epub 2019 Jan 15.

1Department of Morphology, Surgery and Experimental Medicine, Intensive Care Section, University of Ferrara, 44121 Ferrara, Italy.

Acute lung injury (ALI) affects over 10% of patients hospitalised in critical care, with acute respiratory distress syndrome (ARDS) being the most severe form of ALI and having a mortality rate in the region of 40%. There has been slow but incremental progress in identification of biomarkers that contribute to the pathophysiology of ARDS, have utility in diagnosis and monitoring, and that are potential therapeutic targets (Calfee CS, Delucchi K, Parsons PE, Thompson BT, Ware LB, Matthay MA, Thompson T, Ware LB, Matthay MA, Lancet Respir Med 2014, 2:611--620). However, a major issue is that ARDS is such a heterogeneous, multi-factorial, end-stage condition that the strategies for "lumping and splitting" are critical (Prescott HC, Calfee CS, Thompson BT, Angus DC, Liu VX, Am J Respir Crit Care Med 2016, 194:147--155). Read More

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http://dx.doi.org/10.1186/s12950-018-0202-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332898PMC
January 2019
3 Reads
2.024 Impact Factor

Human Lung Cell Pyroptosis Following Traumatic Brain Injury.

Cells 2019 Jan 18;8(1). Epub 2019 Jan 18.

Department of Physiology and Biophysics, University of Miami School of Medicine, 1600 NW 10th Ave. RMSB 5054, Miami, FL 33136, USA.

Approximately 30% of traumatic brain injured patients suffer from acute lung injury or acute respiratory distress syndrome. Our previous work revealed that extracellular vesicle (EV)-mediated inflammasome signaling plays a crucial role in the pathophysiology of traumatic brain injury (TBI)-induced lung injury. Here, serum-derived EVs from severe TBI patients were analyzed for particle size, concentration, origin, and levels of the inflammasome component, an apoptosis-associated speck-like protein containing a caspase-recruiting domain (ASC). Read More

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http://dx.doi.org/10.3390/cells8010069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356886PMC
January 2019
1 Read

Ayurveda management of Guillain-Barre syndrome: A case report.

J Ayurveda Integr Med 2019 Jan 18. Epub 2019 Jan 18.

Department of Kayachikita, Shri BMK Ayurveda Mahavidyalaya, A Constitunet Unit of KLE Academy of Higher Education & Research, Belagavi, Karnataka, India.

Guillain-Barre syndrome (GBS) is a severe acute paralytic neuropathy with rapid progression usually occurring post infections. Inspite of the active medications it is associated with severe weakness, incomplete recovery and pain. Long disease course can cause autonomic dysfunction or deterioration in general health and life threatening complications like respiratory failures. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09759476173080
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http://dx.doi.org/10.1016/j.jaim.2018.08.004DOI Listing
January 2019
4 Reads

Feasibility of an alternative, physiologic, individualized open-lung approach to high-frequency oscillatory ventilation in children.

Ann Intensive Care 2019 Jan 18;9(1). Epub 2019 Jan 18.

Department of Paediatrics, Division of Paediatric Critical Care Medicine, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Huispost CA 80, P.O. Box 30.001, 9700 RB, Groningen, The Netherlands.

Background: High-frequency oscillatory ventilation (HFOV) is a common but unproven management strategy in paediatric critical care. Oscillator settings have been traditionally guided by patient age and/or weight rather than by lung mechanics, thereby potentially negating any beneficial effects. We have adopted an open-lung HFOV strategy based on a corner frequency approach using an initial incremental-decremental mean airway pressure titration manoeuvre, a high frequency (8-15 Hz), and high power to initially target a proximal pressure amplitude (∆P) of 70-90 cm HO, irrespective of age or weight. Read More

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https://annalsofintensivecare.springeropen.com/articles/10.1
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http://dx.doi.org/10.1186/s13613-019-0492-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338613PMC
January 2019
6 Reads

Vascular endothelial cadherin shedding is more severe in sepsis patients with severe acute kidney injury.

Crit Care 2019 Jan 18;23(1):18. Epub 2019 Jan 18.

Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, T1218 MCN, 1161 21st, Avenue S, Nashville, TN, 37232, USA.

Background: Vascular endothelial cadherin (VE-cadherin) is a membrane protein that is the major component of adherens junctions between endothelial cells. It is crucial for regulating vascular integrity, endothelial permeability, and angiogenesis. During inflammatory processes, VE-cadherin is shed into circulation (sVE-cadherin). Read More

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https://ccforum.biomedcentral.com/articles/10.1186/s13054-01
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http://dx.doi.org/10.1186/s13054-019-2315-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339439PMC
January 2019
5 Reads

Middle East Respiratory Syndrome Vaccine Candidates: Cautious Optimism.

Viruses 2019 Jan 17;11(1). Epub 2019 Jan 17.

Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, 77555 TX, USA.

Efforts towards developing a vaccine for Middle East respiratory syndrome coronavirus (MERS-CoV) have yielded promising results. Utilizing a variety of platforms, several vaccine approaches have shown efficacy in animal models and begun to enter clinical trials. In this review, we summarize the current progress towards a MERS-CoV vaccine and highlight potential roadblocks identified from previous attempts to generate coronavirus vaccines. Read More

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http://www.mdpi.com/1999-4915/11/1/74
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http://dx.doi.org/10.3390/v11010074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356267PMC
January 2019
7 Reads

Hypersensitivity Reactions in Serious Adverse Events Reported for Paracetamol in the EudraVigilance Database, 2007⁻2018.

Pharmacy (Basel) 2019 Jan 17;7(1). Epub 2019 Jan 17.

Department of Clinical and Environmental Allergology, Jagiellonian University Medical College, 31-531 Krakow, Poland.

Paracetamol is a popular and easily available drug which is used world-wide as analgesic, antipyretic agent. Hypersensitivity reactions to this drug involve a wide range of symptoms of various importance for patient management. The EudraVigilance (EV) database serves as a system for monitoring adverse events (AE) due to drug intake. Read More

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http://dx.doi.org/10.3390/pharmacy7010012DOI Listing
January 2019
4 Reads

Positive end-expiratory pressure titration with electrical impedance tomography and pressure-volume curve in severe acute respiratory distress syndrome.

Ann Intensive Care 2019 Jan 17;9(1). Epub 2019 Jan 17.

Institute of Technical Medicine, Furtwangen University, Villingen-Schwenningen, Germany.

Background: The study objective was to compare titration of positive end-expiratory pressure (PEEP) with electrical impedance tomography (EIT) and with ventilator-embedded pressure-volume loop in severe acute respiratory distress syndrome (ARDS).

Methods: We have designed a prospective study with historical control group. Twenty-four severe ARDS patients (arterial oxygen partial pressure to fractional inspired oxygen ratio, PaO/FiO < 100 mmHg) were included in the EIT group and examined prospectively. Read More

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http://dx.doi.org/10.1186/s13613-019-0484-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336593PMC
January 2019
1 Read

Angiopoietin-2 as a predictor of acute kidney injury in critically ill patients and association with ARDS.

Respirology 2019 Jan 17. Epub 2019 Jan 17.

Medical Sciences Postgraduate Program, Universidade de Fortaleza - UNIFOR, Fortaleza, Brazil.

Background And Objective: Angiopoietin-2 (AGPT2) has been proposed as a key mediator of organ dysfunction, mainly in acute respiratory distress syndrome (ARDS). It has also been associated with acute kidney injury (AKI). We aimed to investigate the role of AGPT2 in patients with and without ARDS. Read More

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http://doi.wiley.com/10.1111/resp.13464
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http://dx.doi.org/10.1111/resp.13464DOI Listing
January 2019
7 Reads

From SARS to MERS, Thrusting Coronaviruses into the Spotlight.

Viruses 2019 Jan 14;11(1). Epub 2019 Jan 14.

Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) & Comparative Medicine Centre, Peking Union Medical Collage (PUMC), Beijing 100021, China.

Coronaviruses (CoVs) have formerly been regarded as relatively harmless respiratory pathogens to humans. However, two outbreaks of severe respiratory tract infection, caused by the severe acute respiratory syndrome coronavirus (SARS-CoV) and the Middle East respiratory syndrome coronavirus (MERS-CoV), as a result of zoonotic CoVs crossing the species barrier, caused high pathogenicity and mortality rates in human populations. This brought CoVs global attention and highlighted the importance of controlling infectious pathogens at international borders. Read More

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http://www.mdpi.com/1999-4915/11/1/59
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http://dx.doi.org/10.3390/v11010059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357155PMC
January 2019
4 Reads
3.279 Impact Factor

Structure of interferon-stimulated gene product 15 (ISG15) from the bat species Myotis davidii and the impact of interdomain ISG15 interactions on viral protein engagement.

Acta Crystallogr D Struct Biol 2019 Jan 4;75(Pt 1):21-31. Epub 2019 Jan 4.

Pharmaceutical and Biomedical Sciences, University of Georgia, 240 West Green Street, Athens, GA 30602, USA.

Bats have long been observed to be the hosts and the origin of numerous human diseases. Bats, like all mammals, rely on a number of innate immune mechanisms to combat invading pathogens, including the interferon type I, II and III responses. Ubiquitin-like interferon-stimulated gene product 15 (ISG15) is a key modulator of these interferon responses. Read More

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http://dx.doi.org/10.1107/S2059798318015322DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333284PMC
January 2019
1 Read

ECMO in severe acute respiratory distress syndrome.

Lancet Respir Med 2019 Feb 11;7(2):106-108. Epub 2019 Jan 11.

Department of Medicine and Department of Anesthesia, Cardiovascular Research Institute, University of California, San Francisco Moffitt Hospital, 505 Parnassus Avenue, San Francisco, CA 94143, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22132600183050
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http://dx.doi.org/10.1016/S2213-2600(18)30507-1DOI Listing
February 2019
4 Reads

Venovenous extracorporeal membrane oxygenation for acute respiratory distress syndrome: a systematic review and meta-analysis.

Lancet Respir Med 2019 Feb 11;7(2):163-172. Epub 2019 Jan 11.

Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada; University Health Network and Sinai Health System, Toronto, ON Canada.

Background: Use of extracorporeal membrane oxygenation (ECMO) in adults with severe acute respiratory distress syndrome has increased in the past 10 years. However, the efficacy of venovenous ECMO in people with acute respiratory distress syndrome is uncertain according to the most recent data. We aimed to estimate the effect of venovenous ECMO on mortality from acute respiratory distress syndrome. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22132600183045
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http://dx.doi.org/10.1016/S2213-2600(18)30452-1DOI Listing
February 2019
7 Reads

Association Between Tidal Volumes Adjusted for Ideal Body Weight and Outcomes in Pediatric Acute Respiratory Distress Syndrome.

Pediatr Crit Care Med 2019 Jan 11. Epub 2019 Jan 11.

Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA.

Objectives: The impact of tidal volume on outcomes in mechanically ventilated children with pediatric acute respiratory distress syndrome remains unclear. To date, observational investigations have failed to calculate tidal volume based on standardized corrections of weight. We investigated the impact of tidal volume on mortality and probability of extubation in pediatric acute respiratory distress syndrome using ideal body weight-adjusted tidal volume. Read More

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http://dx.doi.org/10.1097/PCC.0000000000001846DOI Listing
January 2019
5 Reads

How Different is AMAN from AIDP in Childhood GBS? A Prospective Study from North India.

Indian J Pediatr 2019 Jan 12. Epub 2019 Jan 12.

Pediatric Neurology Unit, Department of Pediatrics, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India.

Objectives: To compare the clinical profile and short-term outcome of children with axonal and demyelinating subtypes of childhood Guillain Barré syndrome (GBS).

Methods: This is a prospective observational study conducted in a tertiary care teaching hospital in North India. Consecutive children with Guillain Barré syndrome were recruited to compare the clinical profile and short term outcome among the subtypes. Read More

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http://dx.doi.org/10.1007/s12098-018-2835-5DOI Listing
January 2019
1 Read
0.919 Impact Factor

Bats and Coronaviruses.

Viruses 2019 Jan 9;11(1). Epub 2019 Jan 9.

Department of Pathology and Molecular Medicine, Michael DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, ON L8S 4L8, Canada.

Bats are speculated to be reservoirs of several emerging viruses including coronaviruses (CoVs) that cause serious disease in humans and agricultural animals. These include CoVs that cause severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), porcine epidemic diarrhea (PED) and severe acute diarrhea syndrome (SADS). Bats that are naturally infected or experimentally infected do not demonstrate clinical signs of disease. Read More

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http://dx.doi.org/10.3390/v11010041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356540PMC
January 2019
1 Read

[Clinical characteristics of influenza acute respiratory distress syndrome in 2017 to 2018].

Zhonghua Jie He He Hu Xi Za Zhi 2019 Jan;42(1):9-14

Department of Respiratory and Critical Care Medicine, Beijing Chaoyang Hospital, Capital Medical University; Beijing Institute of Respiratory Medicine; Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders;Beijing Engineering Research Center for Diagnosis and Treatment of Respiratory and Critical Care Medicine (Beijing Chaoyang Hospital), Beijing 100020, China.

To describe the clinical characteristics of acute respiratory distress syndrome (ARDS) caused by severe influenza virus in our hospital. From November 2017 to February 2018, 48 patients were diagnosed with ARDS caused by influenza virus pneumonia. There characteristics, treatment, and outcomes were summarized and analyzed. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1001-0939.2019.01.005DOI Listing
January 2019
4 Reads