2,475 results match your criteria Serum Sickness


Functional recombinant single-chain variable fragment antibody against venom.

Exp Ther Med 2019 May 6;17(5):3768-3774. Epub 2019 Mar 6.

Department of Emergency, Southwest Hospital of the Third Military Medical University, Chongqing 400038, P.R. China.

bites are conventionally treated with animal-derived antivenom, the use of which is limited due to allergic reactions and serum sickness. Thus in the present study, the genes of humanized antibodies produced in response to venom were extracted from lymphocytes from patients bitten by . A single-chain variable fragment (scFv) library against venom was constructed using a T7 phage display system. Read More

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http://www.spandidos-publications.com/10.3892/etm.2019.7348
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http://dx.doi.org/10.3892/etm.2019.7348DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447787PMC
May 2019
1 Read
0.941 Impact Factor

Effects of leaf extract on lipopolysaccharide -induced neuroinflammation in rats: A behavioral and H NMR-based metabolomics study.

Avicenna J Phytomed 2019 Mar-Apr;9(2):164-186

Laboratory of Natural Products, Institute of Bioscience, Universiti Putra Malaysia, Serdang, Selangor, Malaysia.

Objective: This research revealed the biochemical outcomes of metabolic dysregulation in serum associated with physiological sickness behavior following lipopolysaccharide (LPS)-induced neuroinflammation in rats, and treatment with (CN). Verification of H NMR analysis of the CN aqueous extract proved the existence of bioactive phytochemical constituents' in extract.

Materials And Methods: Twenty-five rats were subjected to unilateral stereotaxic injection of 10 µL LPS (1 mg/mL), while another ten rats were injected with phosphate-buffered saline (PBS, 10 µL) as control. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448548PMC
April 2019
1 Read

Intermittent normobaric hypoxia facilitates high altitude acclimatization by curtailing hypoxia-induced inflammation and dyslipidemia.

Pflugers Arch 2019 Apr 13. Epub 2019 Apr 13.

Defence Research and Development Organisation, Defence Institute of Physiology and Allied Sciences (DIPAS), Lucknow Road, Timarpur, New Delhi, 110054, India.

Intermittent hypoxic training (IHT) is a discrete cost-effective method for improving athletic performance and high altitude acclimatization. Unfortunately, IHT protocols widely vary in terms of hypoxia severity, duration, and number of cycles affecting physiological outcomes. In the present study, we evaluated the efficacy of a moderate normobaric IHT protocol (12% FiO for 4 h, 4 days) on acclimatization to high altitude (3250 m). Read More

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http://dx.doi.org/10.1007/s00424-019-02273-4DOI Listing

Neuroinflammation induced by lipopolysaccharide causes cognitive impairment in mice.

Sci Rep 2019 Apr 8;9(1):5790. Epub 2019 Apr 8.

Department of Pathophysiology, Key Laboratory of State Administration of Traditional Chinese Medicine of the People's Republic of China, School of Medicine, Jinan University, Guangzhou, Guangdong, China.

In this study, we investigated lipopolysaccharide (LPS)-induced cognitive impairment and neuroinflammation in C57BL/6J mice by using behavioral tests, immunofluorescence, enzyme-linked immunosorbent assay (ELISA) and Western blot. We found that LPS treatment leads to sickness behavior and cognitive impairment in mice as shown in the Morris water maze and passive avoidance test, and these effects were accompanied by microglia activation (labeled by ionized calcium binding adaptor molecule-1, IBA-1) and neuronal cell loss (labeled by microtubule-associated protein 2, MAP-2) in the hippocampus. The levels of interleukin-4 (IL-4) and interleukin-10 (IL-10) in the serum and brain homogenates were reduced by the LPS treatment, while the levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), prostaglandin E2 (PGE) and nitric oxide (NO) were increased. Read More

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http://www.nature.com/articles/s41598-019-42286-8
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http://dx.doi.org/10.1038/s41598-019-42286-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453933PMC
April 2019
4 Reads

Snake Eyes: Coral Snake Neurotoxicity Associated With Ocular Absorption of Venom and Successful Treatment With Exotic Antivenom.

J Emerg Med 2019 Mar 14. Epub 2019 Mar 14.

Department of Emergency Medicine, Baylor Scott and White Medical Center - Temple, Texas A&M Health Science Center College of Medicine, Temple, Texas.

Background: Coral snake bites from Micrurus fulvius and Micrurus tener account for < 1% of all snake bites in North America. Coral snake envenomation may cause significant neurotoxicity, including respiratory insufficiency, and its onset may be delayed up to 13 h.

Case Report: We present a unique patient encounter of M. Read More

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http://dx.doi.org/10.1016/j.jemermed.2019.01.019DOI Listing
March 2019
1 Read

Association of chronic inflammation and perceived stress with abnormal functional connectivity in brain areas involved with interoception in hepatitis C patients.

Brain Behav Immun 2019 Mar 11. Epub 2019 Mar 11.

Department of Psychiatry and Psychology, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigacion Biomédica en Red de Salud Mental (CIBERSAM), Barcelona, Spain; Department of Medicine, Faculty of Medicine, and Institute of Neuroscience, University of Barcelona (UB), Barcelona, Spain. Electronic address:

Background: Sickness behavioral changes elicited by inflammation may become prolonged and dysfunctional in patients with chronic disease, such as chronic hepatitis C (CHC). Neuroimaging studies show that the basal ganglia and insula are sensitive to systemic inflammation.

Aim: To elucidate the clinical and neurobiological aspects of prolonged illnesses in patients with CHC. Read More

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http://dx.doi.org/10.1016/j.bbi.2019.03.008DOI Listing
March 2019
1 Read

Diagnosing bluetongue virus in domestic ruminants: current perspectives.

Vet Med (Auckl) 2019 14;10:17-27. Epub 2019 Feb 14.

Centro de Investigación en Sanidad Animal (CISA-INIA), Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, Valdeolmos, Madrid, Spain,

This review provides an overview of current and potential new diagnostic techniques against bluetongue virus (BTV), an transmitted by arthropods that affects ruminants. Bluetongue is a disease currently notifiable to the World Organization for Animal Health (OIE), causing great economic losses due to decreased trade associated with bluetongue outbreaks and high mortality and morbidity. BTV cross-reacts with many antigenically related viruses including viruses that causes African Horse sickness and epizootic haemorrhagic disease of deer. Read More

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http://dx.doi.org/10.2147/VMRR.S163804DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385761PMC
February 2019
1 Read

Dendritic cell-based immunization induces Coccidioides Ag2/PRA-specific immune response.

Vaccine 2019 Mar 20;37(12):1685-1691. Epub 2019 Feb 20.

Department of Pharmaceutical Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.

Valley Fever, or coccidioidomycosis, is caused by a soil-borne, highly virulent fungal pathogen, Coccidioides spp. Infection with Coccidioides can be life-threatening. Since an effective treatment is not available and the T cell-mediated immune response is protective, vaccine development is of interest. Read More

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http://dx.doi.org/10.1016/j.vaccine.2019.01.034DOI Listing

Dietary Iron Deficiency Impaired Peripheral Immunity but Did Not Alter Brain Microglia in PRRSV-Infected Neonatal Piglets.

Front Immunol 2018 4;9:3150. Epub 2019 Feb 4.

Division of Nutritional Sciences, University of Illinois at Urbana-Champaign, Urbana, IL, United States.

During the postnatal period the developing brain is vulnerable to insults including nutrient insufficiency and infection that may lead to disrupted development and cognitive dysfunction. Since iron deficiency (ID) often presents with immunodeficiency, the objective of this study was to investigate peripheral viremia and inflammation as well as brain microglial phenotype and function when ID and respiratory infection occur simultaneously in a neonatal piglet model. On postnatal day 2 (PD 2) male and female piglets were assigned to one of four treatments and fed either control or ID milk replacer. Read More

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http://dx.doi.org/10.3389/fimmu.2018.03150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369153PMC
February 2019
6 Reads

Clinical and Neuropathogenetic Aspects of Human African Trypanosomiasis.

Front Immunol 2019 25;10:39. Epub 2019 Jan 25.

Institute of Biodiversity, Animal Health and Comparative Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.

Trypanosomiasis has been recognized as a scourge in sub-Saharan Africa for centuries. The disease, caused by protozoan parasites of the genus, is a major cause of mortality and morbidity in animals and man. Human African trypanosomiasis (HAT), or sleeping sickness, results from infections with or with accounting for over 95% of infections. Read More

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https://www.frontiersin.org/article/10.3389/fimmu.2019.00039
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http://dx.doi.org/10.3389/fimmu.2019.00039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355679PMC
January 2019
16 Reads

Lymphoid Interstitial Pneumonia in Common Variable Immune Deficiency - Case Report With Disease Monitoring in Various Therapeutic Options: Pleiotropic Effects of Rituximab Regimens.

Front Pharmacol 2018 18;9:1559. Epub 2019 Jan 18.

Department of Immunology of Infectious Diseases, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland.

Lymphoid interstitial pneumonia (LIP) is a rare lymphoproliferative disease. LIP in common variable immunodeficiency (CVID) was observed in a patient during immunomodulatory therapy after progression of the disease (i.e. Read More

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http://dx.doi.org/10.3389/fphar.2018.01559DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346143PMC
January 2019
3 Reads

Influence of prenatal transportation stress on innate immune response to an endotoxin challenge in weaned Brahman bull calves.

Stress 2019 Mar 24;22(2):236-247. Epub 2019 Jan 24.

a Texas A&M AgriLife Research , Texas A&M University System , Overton , TX , USA.

The objective of this study was to assess the influence of prenatal stress (PNS) on innate immune responses to an endotoxin challenge in weaned bull calves. Altered innate immune response to lipopolysaccharide (LPS), as characterized by changes in a range of variables was hypothesized in PNS bull calves. Brahman cows (n = 96; 48 stressed by transportation at five stages of gestation and 48 Controls) produced 85 calves, from which 16 uncastrated male (bull) calves from each PNS and Control treatment were selected for an LPS challenge period. Read More

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http://dx.doi.org/10.1080/10253890.2018.1523895DOI Listing
March 2019
2 Reads

Dermatomyositis associated with omalizumab therapy for severe asthma: a case report.

Allergy Asthma Clin Immunol 2019 17;15. Epub 2019 Jan 17.

3Department of Medicine, Western University, London, ON Canada.

Background: Omalizumab is a humanized monoclonal antibody widely used for treatment of persistent allergic asthma and antihistamine-refractory chronic urticaria. Immediate adverse events to omalizumab are well characterized. Delayed anaphylactoid and serum sickness-like reactions have also been described; however, their relationship to the drug remains uncertain, and the frequency is unknown. Read More

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http://dx.doi.org/10.1186/s13223-019-0319-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337756PMC
January 2019
2 Reads

[Preparation and identification of monoclonal antibodies against African horse sickness virus VP7].

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2018 Dec;34(12):1125-1129

Institute of Animal Quarantine, Chinese Academy of Inspection and Quarantine, Beijing 100176, China. *Corresponding author, E-mail:

Objective To prepare the monoclonal antibody (mAb) against the African horsefever virus (AHSV) VP7 protein and to identify it. Methods mAbs were prepared by using baculovirus expressed VP7 protein in BALB/c mice, and the effect of mAb was detected by ELISA, indirect immunofluorescence assay (IFA), and AHSV positive serum blockade. Results Four mAb strains were selected, including 20A8, 28B3, 30G8 and 47E6, among which 47E6 had the best blocking effect. Read More

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December 2018
6 Reads

Juvenile Arthritis Patients Suffering from Chronic Inflammation Have Increased Activity of Both IDO and GTP-CH1 Pathways But Decreased BH4 Efficacy: Implications for Well-Being, Including Fatigue, Cognitive Impairment, Anxiety, and Depression.

Pharmaceuticals (Basel) 2019 Jan 8;12(1). Epub 2019 Jan 8.

Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Faculty of Science, Universities 99, 3584 CG Utrecht, The Netherlands.

Juvenile idiopathic arthritis (JIA) represents joint inflammation with an unknown cause that starts before the age of 16, resulting in stiff and painful joints. In addition, JIA patients often report symptoms of sickness behavior. Recent animal studies suggest that proinflammatory cytokines produce sickness behavior by increasing the activity of indoleamine-2,3-dioxygenase (IDO) and guanosinetriphosphate⁻cyclohydrolase-1 (GTP⁻CH1). Read More

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http://dx.doi.org/10.3390/ph12010009DOI Listing
January 2019
3 Reads

[Effect of Ronghuang Granule on serum FGF23, FGFRs and Klotho in non-dialysis patients with CKD-MBD and kidney deficiency and damp-heat syndrome].

Nan Fang Yi Ke Da Xue Xue Bao 2018 Dec;38(12):1427-1432

First Affiliated Hospital, Anhui University of Chinese Medicine, Heifei 230000, China.

Objective: To observe the effect of Ronghuang granule on serum fibroblast growth factor 23 (FGF23), fibroblast growth factor receptor (FGFRs) and Klotho protein levels in non-dialysis patients with chronic kidney disease-mineral and bone disorder (CKD-MBD) and kidney deficiency and damp heat syndrome.

Methods: Seventy non-dialysis CKD-MBD patients with kidney deficiency and dampness-heat syndrome were randomized into control group (=35) and treatment group (=35). All the patients were given routine treatment combined with traditional Chinese medicine retention enema, and the patients in the treatment group received additional Ronghuang granule treatment (3 times a day). Read More

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http://dx.doi.org/10.12122/j.issn.1673-4254.2018.12.05DOI Listing
December 2018
4 Reads

Bioinspired Design of Lysolytic Triterpenoid-Peptide Conjugates that Kill African Trypanosomes.

Chembiochem 2019 Jan 3. Epub 2019 Jan 3.

Molecular Genetics, Darmstadt University of Technology, Schnittspahnstrasse 10, 64287, Darmstadt, Germany.

Humans have evolved a natural immunity against Trypanosoma brucei infections, which is executed by two serum (lipo)protein complexes known as trypanolytic factors (TLF). The active TLF ingredient is the primate-specific apolipoprotein L1 (APOL1). The protein has a pore-forming activity that kills parasites by lysosomal and mitochondrial membrane fenestration. Read More

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http://dx.doi.org/10.1002/cbic.201800674DOI Listing
January 2019
3 Reads

Hepatoprotective effects of leaf extract on carbon tetrachloride-induced hepatotoxicity in rats.

J Educ Health Promot 2018 27;7:147. Epub 2018 Nov 27.

Clinical Education Research Center, Zeinabieh Hospital, Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

Introduction: Hepatic sickness is a serious problem for human health. The researchers are interested in using medicinal plants including barberry to cure many of these sicknesses. In this study, the effect of hydroalcoholic extract of leaf on hepatic protection was assessed in rats. Read More

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http://dx.doi.org/10.4103/jehp.jehp_48_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282695PMC
November 2018
13 Reads

Detection of specific immune response in sole (Solea senegalensis) against Photobacterium damselae subsp. piscicida antigens.

Fish Shellfish Immunol 2019 Mar 24;86:942-946. Epub 2018 Dec 24.

Universidad de Málaga, Departamento de Microbiología, 29071, Málaga, Spain. Electronic address:

The pathogenic bacteria Photobacterium damselae subsp. piscicida affects the development of Solea senegalensis culture. Vaccines made with inactivated cells have produced a relative protection against the sickness, however the administration of subcellular and purified antigens as vaccine could increase the effectiveness of the immune response. Read More

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http://dx.doi.org/10.1016/j.fsi.2018.12.050DOI Listing
March 2019
3 Reads

Successful Treatment of Pemphigus Vulgaris With Ofatumumab

J Drugs Dermatol 2018 12;17(12):1338-1339

Rituximab is a chimeric anti-CD20 monoclonal antibody that is very effective in treating patients with pemphigus vulgaris. Though infrequent, the development of human anti-chimeric antibodies in patients receiving rituximab results in loss of efficacy. Ofatumumab is a second-generation fully-human anti-CD20 monoclonal antibody currently used to treat chronic lymphocytic leukemia. Read More

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December 2018
6 Reads

A diver with immersion pulmonary oedema and prolonged respiratory symptoms.

Diving Hyperb Med 2018 Dec;48(4):259-261

Department of Pulmonary Medicine, Kameda Medical Centre, Kamogawa, Chiba, Japan.

Immersion pulmonary oedema (IPE) is particularly associated with an excessive reaction to exercise and/or cold stress. IPE usually resolves without recompression therapy within a day or two. Herein we report a diver diagnosed with IPE, in whom symptoms persisted for five days. Read More

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http://dx.doi.org/10.28920/dhm48.4.259-261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355313PMC
December 2018
20 Reads

Serum sickness disease in a patient with alopecia areata and Meniere' disease after PRP procedure.

Dermatol Ther 2019 03 8;32(2):e12798. Epub 2019 Jan 8.

Department of Dermatology, Sexually Transmitted Diseases and Clinical Immunology, The University of Warmia and Mazury, Olsztyn, Poland.

Background: Platelet rich plasma procedure (PRP) is considered to be one of the safest aesthetic procedures. Adverse reactions after PRP administration are extreme rare.

Purpose: We present the patient with serum sickness disease (SSD) after PRP procedure. Read More

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http://dx.doi.org/10.1111/dth.12798DOI Listing
March 2019
17 Reads

History of major depression is associated with neuropsychiatric symptoms but not systemic inflammation in a cross-sectional study in obese patients.

Brain Behav Immun 2019 Feb 23;76:215-222. Epub 2018 Nov 23.

INRA, Nutrition and Integrative Neurobiology (NutriNeuro), UMR 1286, 33076 Bordeaux, France; University of Bordeaux, Nutrition and Integrative Neurobiology (NutriNeuro), UMR 1286, 33076 Bordeaux, France. Electronic address:

Obesity is a major public health burden associated with neuropsychiatric comorbidities leading to social and occupational impairment. Given the growing prevalence of both obesity and mental disorders worldwide, understanding the risk factors of obesity-related neuropsychiatric comorbidities is crucial to develop preventive strategies and individualized treatments. Recent findings suggest that adiposity-driven inflammation contributes to neuropsychiatric comorbidities in obesity. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08891591183030
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http://dx.doi.org/10.1016/j.bbi.2018.11.312DOI Listing
February 2019
13 Reads

Proteome characterization in various biological fluids of Trypanosoma brucei gambiense-infected subjects.

J Proteomics 2019 Mar 7;196:150-161. Epub 2018 Nov 7.

Institute of Neuroepidemiology and Tropical Neurology, School of Medicine, CNRS FR 3503 GEIST, University of Limoges, INSERM UMR 1094 Tropical Neuroepidemiology, Limoges, France. Electronic address:

Human African trypanosomiasis (HAT) is a neglected tropical disease that is endemic in sub-Saharan Africa. Control of the disease has been recently improved by better screening and treatment strategies, and the disease is on the WHO list of possible elimination. However, some physiopathological aspects of the disease transmission and progression remain unclear. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18743919183039
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http://dx.doi.org/10.1016/j.jprot.2018.11.005DOI Listing
March 2019
16 Reads

Protective Effects of Chinese Traditional Medicine Longhu Rendan against Atherosclerosis via Negative Regulation of LOX-1.

Evid Based Complement Alternat Med 2018 8;2018:4812639. Epub 2018 Oct 8.

Guangdong Pharmaceutical University, Guangzhou, Guangdong 510006, China.

Longhu Rendan (LHRD), a Chinese traditional compound medicine, has a remarkable treatment effect on motion sickness for about half a century. However, the role of LHRD in atherosclerosis treatment is still unclear. In this study, LHRD treatment significantly diminished total cholesterol (TC), triglyceride (TG), and low-density lipoprotein cholesterol (LDL-C) levels in apolipoprotein E gene-knockout (ApoE) mice fed with high fat and high cholesterol diet (western diet). Read More

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https://www.hindawi.com/journals/ecam/2018/4812639/
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http://dx.doi.org/10.1155/2018/4812639DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196979PMC
October 2018
8 Reads

Development and validation of a sensitive LC-MS/MS method for the estimation of scopolamine in human serum.

J Pharm Biomed Anal 2019 Feb 28;164:41-46. Epub 2018 Sep 28.

University of Minnesota, Department of Pharmaceutics, College of Pharmacy, Minneapolis, MN United States. Electronic address:

Scopolamine is an anticholinergic alkaloid that is widely used in the form of a transdermal system to manage nausea associated with motion sickness. Currently available methods to quantify scopolamine require large sample volumes and involve cumbersome sample preparation. In this work, a simple method for the rapid separation and sensitive quantification of scopolamine in human serum was developed. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07317085183109
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http://dx.doi.org/10.1016/j.jpba.2018.09.051DOI Listing
February 2019
13 Reads
2.980 Impact Factor

Avoiding a Rash Diagnosis: Rituximab-Induced Serum Sickness.

J Clin Rheumatol 2018 Oct 23. Epub 2018 Oct 23.

Department of Internal Medicine University of Texas at Austin Austin, TX Division of Rheumatology University of Washington Seattle, WA.

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http://dx.doi.org/10.1097/RHU.0000000000000918DOI Listing
October 2018
17 Reads

Effect of Oral Vitamin C Supplementation on High-Altitude Hyperuricemia in Young Men Initially Migrating to High Altitude: A Pilot Study.

High Alt Med Biol 2018 Dec 24;19(4):373-381. Epub 2018 Oct 24.

1 Department of Infectious Disease, Kunming General Hospital of Chengdu Military Command, Kunming, China.

Objective: Clinical studies have shown that oral vitamin C supplementation can reduce serum uric acid levels in multiple populations and may also improve acute mountain sickness. However, it is unclear whether this protocol can improve high-altitude hyperuricemia. Therefore, we aimed to evaluate the role of vitamin C supplementation on high-altitude hyperuricemia. Read More

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http://dx.doi.org/10.1089/ham.2018.0058DOI Listing
December 2018
3 Reads

Efficacy and safety of etanercept for postoperative pyoderma gangrenosum after infliximab serum sickness.

Dermatol Ther 2019 01 20;32(1):e12774. Epub 2018 Nov 20.

Assistance Publique- Hôpitaux de Paris, Département de Dermatologie, Hôpital Saint-Louis, Paris, France.

Non-peristomal postoperative pyoderma gangrenosum (PPG) is a rare subtype of pyoderma gangrenosum that occurs in the early postoperative period at surgical incisions, most commonly after breast surgery. Early diagnosis and treatment is essential to prevent severe scaring. TNF-alpha inhibitor infliximab was reported to be efficient in treatment of PPG refractory to systemic corticosteroids. Read More

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http://dx.doi.org/10.1111/dth.12774DOI Listing
January 2019
5 Reads

Corticosterone and pyridostigmine/DEET exposure attenuate peripheral cytokine expression: Supporting a dominant role for neuroinflammation in a mouse model of Gulf War Illness.

Neurotoxicology 2019 01 16;70:26-32. Epub 2018 Oct 16.

Health Effects Laboratory Division, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV, USA. Electronic address:

Gulf War Illness (GWI) is a chronic multi-symptom disorder experienced by as many as a third of the veterans of the 1991 Gulf War; the constellation of "sickness behavior" symptoms observed in ill veterans is suggestive of a neuroimmune involvement. Various chemical exposures and conditions in theater have been implicated in the etiology of the illness. Previously, we found that GW-related organophosphates (OPs), such as the sarin surrogate, DFP, and chlorpyrifos, cause neuroinflammation. Read More

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http://dx.doi.org/10.1016/j.neuro.2018.10.006DOI Listing
January 2019
5 Reads
3.380 Impact Factor

Inhibitory effects of ascorbic acid toward snake venom metalloproteinase (SVMP) from Indian Echis carinatus venom: Insights from molecular modeling and binding studies.

J Biochem Mol Toxicol 2018 Dec 1;32(12):e22224. Epub 2018 Oct 1.

Centre of Advanced Studies in Crystallography and Biophysics, University of Madras, Guindy Campus, Chennai, Tamil Nadu, India.

Classical antivenom therapy is unable to shield complications of viper bite and has limitations such as anaphylaxis and serum sickness. Snake venom metalloproteinases are responsible for local tissue damage and hemorrhage at the bitten site in viper envenomation, and this has led to a persistent search for metalloproteinase inhibitors. Here, we report the inhibitory effects of ascorbic acid against metalloproteinase from Echis carinatus venom both in-silico and in-vitro. Read More

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http://dx.doi.org/10.1002/jbt.22224DOI Listing
December 2018
7 Reads

Tumour-derived leukaemia inhibitory factor is a major driver of cancer cachexia and morbidity in C26 tumour-bearing mice.

J Cachexia Sarcopenia Muscle 2018 Dec 30;9(6):1109-1120. Epub 2018 Sep 30.

Department of Health Sciences, Boston University, Boston, MA, 02215, USA.

Background: Cancer cachexia is a metabolic wasting syndrome that is strongly associated with a poor prognosis. The initiating factors causing fat and muscle loss are largely unknown. Previously, we found that leukaemia inhibitory factor (LIF) secreted by C26 colon carcinoma cells was responsible for atrophy in treated myotubes. Read More

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http://dx.doi.org/10.1002/jcsm.12346DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240747PMC
December 2018
3 Reads

The potential usefulness of serum biomarkers in high-altitude medicine.

Authors:
B Basnyat

J Travel Med 2018 01;25(1)

Oxford University Clinical Research Unit-Patan Academy of Health Sciences, Lalitpur, Nepal. Center for Tropical Medicine and Global Health, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1093/jtm/tay083DOI Listing
January 2018
1 Read

Prospective Analysis of the Effects of Maternal Immune Activation on Rat Cytokines during Pregnancy and Behavior of the Male Offspring Relevant to Schizophrenia.

eNeuro 2018 Jul-Aug;5(4). Epub 2018 Aug 29.

Department of Physiology, University of Saskatchewan, Saskatoon S7N 5E5, Saskatchewan, Canada.

Influenza during pregnancy is associated with the development of psychopathology in the offspring. We sought to determine whether maternal cytokines produced following administration of viral mimetic polyinosinic-polycytidylic acid (polyI:C) to pregnant rats were predictive of behavioral abnormalities in the adult offspring. Timed-pregnant Sprague Dawley rats received a single intravenous injection of 4-mg/kg polyI:C or saline on gestational day (GD)15. Read More

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http://eneuro.org/lookup/doi/10.1523/ENEURO.0249-18.2018
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http://dx.doi.org/10.1523/ENEURO.0249-18.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6140112PMC
March 2019
6 Reads

Serum sickness (Like Reaction) in a patient treated with alemtuzumab for multiple sclerosis: A case report.

Mult Scler Relat Disord 2018 Nov 11;26:52-54. Epub 2018 Sep 11.

Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI), University of Genoa, Italy; Ospedale Policlinico San Martino IRCCS, Genoa, Italy; Center of Excellence for Biomedical Research (CEBR), University of Genoa, Genoa, Italy.

Background: Alemtuzumab is a monoclonal antibody approved for relapsing-remitting multiple sclerosis (RRMS). The only report of Serum Sickness (SS) in a MS patient occurred during treatment with natalizumab. Non-protein drugs, such as some antibiotics, may induce "SS-like" reactions (SSLR), whose clinical and laboratory features may partially overlap with the traditional SS. Read More

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http://dx.doi.org/10.1016/j.msard.2018.09.006DOI Listing
November 2018
3 Reads

Fatty diet, active hydrophobic spots, and decompression sickness.

Authors:
Ran Arieli

Diving Hyperb Med 2018 Sep;48(3):197

Corresponding author: The Israel Naval Medical Institute, Israel Defence Forces Medical Corps, Haifa, Israel; Eliachar Research Laboratory, Western Galilee Medical Centre, Nahariya, Israel, 12 Klil-Hakhoresh, Rakefet, D.N. Misgav 2017500, Israel,

In a study of the effect of a fatty diet on decompression bubbles, based on the responses to a questionnaire regarding daily food consumption, the approximate fat intake for each diver was calculated, taking into account the maximum recommended intake for a person doing his type of work. Following hyperbaric exposure, divers were divided into two groups: 'bubblers' (a minimum of the second level on the Kisman-Masurel scale) and 'non-bubblers'. Bubblers had higher fat consumption than non-bubblers (146 ± 39% versus 92 ± 18%). Read More

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http://www.dhmjournal.com/index.php/journals
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http://dx.doi.org/10.28920/dhm48.3.197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205865PMC
September 2018
7 Reads

Sex differences in the peripheral and central immune responses following lipopolysaccharide treatment in pubertal and adult CD-1 mice.

Int J Dev Neurosci 2018 Dec 27;71:94-104. Epub 2018 Aug 27.

School of Psychology, Faculty of Social Sciences, University of Ottawa, Canada. Electronic address:

Puberty is a critical developmental period that is characterized by significant brain development. Exposure to stress during this time can alter brain functioning setting the stage for long-lasting behavioural outcomes. The objective of this study was to investigate age and sex differences in the peripheral and central immune responses, along with sickness behaviour, following immune stress. Read More

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http://dx.doi.org/10.1016/j.ijdevneu.2018.07.012DOI Listing
December 2018
6 Reads

Molecular and serological surveillance of African horse sickness virus in eastern and central Saudi Arabia.

Rev Sci Tech 2017 Dec;36(3):889-898

African horse sickness virus (AHSV) is one of the most devastating viral diseases of the family Equidae. Infection with AHSV threatens not only the Saudi equine industry but also the equine industry worldwide. This is due to the high morbidity and mortality rates among the infected population of up to 100%. Read More

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http://dx.doi.org/10.20506/rst.36.3.2722DOI Listing
December 2017
4 Reads

Foreign body reactions, marginal bone loss and allergies in relation to titanium implants.

Eur J Oral Implantol 2018 ;11 Suppl 1:S37-S46

Aim: To describe general observations of immunological reactions to foreign materials and to realize that CP titanium gives rise to a foreign body reaction with subsequent bone embedment when placed as oral implants. To analyse the possibility of titanium allergy.

Materials And Methods: The present paper is of a narrative review type. Read More

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January 2018
17 Reads

The effects of respiratory inhaled drugs on the prevention of acute mountain sickness.

Medicine (Baltimore) 2018 Aug;97(32):e11788

Department of Transfusion Medicine.

Background: Acute mountain sickness (AMS) is common in high-altitude travelers, and may lead to life-threatening high-altitude cerebral edema (HACE) or high-altitude pulmonary edema (HAPE). The inhaled drugs have a much lower peak serum concentrations and a shorter half-life period than oral drugs, which give them a special character, greater local effects in the lung. Meanwhile, short-term administration of inhaled drugs results in almost no adverse reactions. Read More

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http://dx.doi.org/10.1097/MD.0000000000011788DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133459PMC
August 2018
16 Reads

Assessment of reproducibility of a VP7 Blocking ELISA diagnostic test for African horse sickness.

Transbound Emerg Dis 2019 Jan 2;66(1):83-90. Epub 2018 Aug 2.

The Pirbright Institute, Pirbright, UK.

The laboratory diagnosis of African horse sickness (AHS) is important for: (a) demonstrating freedom from infection in a population, animals or products for trade (b) assessing the efficiency of eradication policies; (c) laboratory confirmation of clinical diagnosis; (d) estimating the prevalence of AHS infection; and (e) assessing postvaccination immune status of individual animals or populations. Although serological techniques play a secondary role in the confirmation of clinical cases, their use is very important for all the other purposes due to their high throughput, ease of use and good cost-benefit ratio. The main objective of this study was to support the validation of AHS VP7 Blocking ELISA up to the Stage 3 of the World Animal Health Organization (OIE) assay validation pathway. Read More

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http://doi.wiley.com/10.1111/tbed.12968
Publisher Site
http://dx.doi.org/10.1111/tbed.12968DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378617PMC
January 2019
11 Reads

Flavonoid-Rich Fraction of Ocimum gratissimum Attenuates Lipopolysaccharide-Induced Sickness Behavior, Inflammatory and Oxidative Stress in Mice.

Drug Res (Stuttg) 2019 Feb 31;69(3):151-158. Epub 2018 Jul 31.

Department of Pharmacology & Therapeutics, College of Medicine, University of Ibadan, Ibadan, Nigeria.

Purpose: L. leaves has been traditionally used for management of febrile illnesses and symptoms typified of sickness behavior. In this work we investigated the modulatory effect of flavonoid-rich fraction of leaves (EAFO) on sickness behavior, inflammatory and oxidative stress responses in LPS-challenged mice. Read More

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http://dx.doi.org/10.1055/a-0654-5042DOI Listing
February 2019
4 Reads

Prevalence of patients with self-reported hidradenitis suppurativa in a cohort of Danish blood donors: a cross-sectional study.

Br J Dermatol 2019 Apr 20;180(4):774-781. Epub 2018 Sep 20.

Department of Dermatology, University Hospital Zealand, Sygehusvej 5, 4000, Roskilde, Denmark.

Background: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease characterized by recurrent inflamed nodules. No pathognomonic test is available for HS; hence the diagnosis is based on three clinical criteria.

Objectives: To estimate the cross-sectional prevalence and characterize patients with HS in the Danish Blood Donor Study cohort. Read More

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http://dx.doi.org/10.1111/bjd.16998DOI Listing
April 2019
26 Reads

Controllable fabrication of bio-bar codes for dendritically amplified sensing of human T-lymphotropic viruses.

Chem Sci 2018 Jun 10;9(22):4942-4949. Epub 2018 May 10.

College of Chemistry, Chemical Engineering and Materials Science , Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong , Key Laboratory of Molecular and Nano Probes , Ministry of Education , Shandong Provincial Key Laboratory of Clean Production of Fine Chemicals , Shandong Normal University , Jinan 250014 , China . Email: ; ; Tel: +86 0531 86186033.

Human T-lymphotropic virus type II (HTLV-II) is an important type-C retrovirus, closely related to a variety of human diseases. Here, we demonstrate for the first time the controllable fabrication of bio-bar codes for dendritically amplified sensing of low-abundant HTLV-II DNA by the integration of terminal deoxynucleotidyl transferase (TdT)-catalyzed template-free polymerization extension with bio-bar-code amplification (BCA). HTLV-II DNA hybridizes with magnetic microparticle (MMP)-modified capture probe 1, forming a stable DNA duplex with a protruding 3'-hydroxylated sequence which may function as a primer to initiate the TdT-catalyzed first-step polymerization extension for the generation of a poly-thymidine (T) sequence. Read More

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http://dx.doi.org/10.1039/c8sc01641kDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5994793PMC
June 2018
12 Reads

Efficacy of different drugs in the treatment of minimal hepatic encephalopathy: A network meta-analysis involving 826 patients based on 10 randomized controlled trials.

J Cell Biochem 2018 Nov 22;119(10):8336-8345. Epub 2018 Jun 22.

The Third Hospital of Heilongjiang Province, Beian, P.R. China.

Minimal hepatic encephalopathy (MHE), a complex neuropsychological complication of cirrhosis, is characterized by delayed reaction time and the inhibition of abnormal response. This network meta-analysis (NMA) was adopted to compare the efficacy of five drugs including lactulose, probiotics, rifaximin, acetyl-L-carnitine (ALC), and L-Ornithine L-aspartate (LOLA) in the treatment of MHE. The Cochrane Library, PubMed, and Embase databases were searched for any existing entail on these five drugs from the inception to February 2018, including Randomized controlled trials (RCTs). Read More

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http://dx.doi.org/10.1002/jcb.26886DOI Listing
November 2018
13 Reads

Low Insulin-like Growth Factor-1 Influences Fatigue and Quality of Life in Children With Inflammatory Bowel Disease.

J Pediatr Gastroenterol Nutr 2018 Nov;67(5):616-621

Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Northwestern Feinberg School of Medicine, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL.

Objective: Fatigue is common among patients with inflammatory bowel disease (IBD). Proinflammatory cytokines are elevated in chronic inflammation and can induce "sickness behaviors," such as fatigue. Chronic inflammatory states also lead to growth hormone resistance, demonstrated by low levels of insulin-like growth factor (IGF-1) and elevated growth hormone. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002057DOI Listing
November 2018
10 Reads

Excessive Erythrocytosis and Cardiovascular Risk in Andean Highlanders.

High Alt Med Biol 2018 Sep 21;19(3):221-231. Epub 2018 May 21.

1 Laboratorio de Fisiología Comparada, Departamento de Ciencias Biológicas y Fisiológicas, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia. Lima , Perú.

Corante, Noemí, Cecilia Anza-Ramírez, Rómulo Figueroa-Mujíca, José Luis Macarlupú, Gustavo Vizcardo-Galindo, Grzegorz Bilo, Gianfranco Parati, Jorge L. Gamboa, Fabiola León-Velarde, and Francisco C. Villafuerte. Read More

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https://www.liebertpub.com/doi/10.1089/ham.2017.0123
Publisher Site
http://dx.doi.org/10.1089/ham.2017.0123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157350PMC
September 2018
12 Reads

Relationship between fatigue symptoms and subjective and objective indicators in hemodialysis patients.

Int Urol Nephrol 2018 Jul 4;50(7):1329-1339. Epub 2018 May 4.

West China Nursing School/West China Hospital, Sichuan University, Chengdu, 610061, Sichuan, China.

Purpose: The purpose of the study was to investigate the major factors affecting fatigue symptoms and to examine the relationships between fatigue symptoms and subjective and objective indicators in patients on hemodialysis (HD).

Methods: Patients on HD who met the inclusion criteria were chosen from two grade A tertiary general hospitals by convenience sampling and cross-sectional survey methods.

Results: A total of 511 patients were included in the study. Read More

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http://dx.doi.org/10.1007/s11255-018-1871-4DOI Listing
July 2018
9 Reads