Search Our Scientific Publications & Authors

Biomark Med 2022 Jun 13. Epub 2022 Jun 13.

Department of Pharmacology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, India.

Lp-PLA2 is an enzyme encoded by the gene located at chromosome 6p12-21, which is included in different signal transduction pathways. The potential of serum levels of Lp-PLA2 as a marker of inflammation quantifying cardio-metabolic risk, renal impairment and oxidative stress has been explored in earlier studies. It has also been used in chronic obstructive pulmonary disease, hepatic disease, metabolic conditions and exercise tolerance. Read More

Antioxidants (Basel) 2022 May 20;11(5). Epub 2022 May 20.

Department of Physiotherapy and Health Sciences, Faculty of Dietetics, Gdańsk College of Health, Pelplińska 7 Str., 80-335 Gdańsk, Poland.

Heat shock proteins (HSPs) have protective effects against oxidative stress and decompression sickness. Nitric oxide may reduce bubble formation during decompression and its activity is regulated by HSPs. A simulated dive can cause the HSP response. Read More

Front Endocrinol (Lausanne) 2022 9;13:871009. Epub 2022 May 9.

Department of Internal Medicine and Oncological Chemotherapy, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Katowice, Poland.

Objective: Management of Graves' orbitopathy remains a challenge. Our previous case report has shown promising results for rabbit antithymocyte globulin (rATG) in the treatment of Graves' orbitopathy.

Design: We present the response of 7 individuals with active moderate-to-severe steroid-resistant Graves' orbitopathy to rATG, representing preliminary results from a prospective single-center study. Read More

CEN Case Rep 2022 May 20. Epub 2022 May 20.

Department of Pediatrics, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama, Yufu, Oita, 879-5593, Japan.

Rituximab (RTX) has been used to treat B cell lineage lymphoma/leukemia or autoimmune or autoinflammatory disorders. RTX therapy has been extensively applied to cases of frequently relapsing nephrotic syndrome (FRNS) and steroid-dependent nephrotic syndrome. Rituximab-induced serum sickness (RISS) has been recognized as a rare severe type-3 hypersensitivity reaction in patients treated with RTX. Read More

Nutrients 2022 May 9;14(9). Epub 2022 May 9.

Department of Obstetrics and Gynecology, Graduate School of Medicine, Hokkaido University, Sapporo 060-8638, Japan.

Among the physiological changes occurring during pregnancy, the benefits of morning sickness, which is likely mediated by human chorionic gonadotropin (HCG) and induces serum ketone production, are unclear. We investigated the relationship between serum levels of ketone bodies and HCG in the first, second, and third trimesters and neonatal body shape (i.e. Read More

Front Immunol 2022 19;13:863177. Epub 2022 Apr 19.

Department of Pediatrics, Division of Hematology/Oncology, University of Michigan, Ann Arbor, MI, United States.

Management of refractory immune thrombocytopenia frequently involves rituximab, a chimeric anti-CD20 monoclonal antibody, to target B cells and induce remission in most patients. However, neutralizing antibodies to rituximab that nullify therapeutic response and may lead to serum sickness have been rarely reported. Here, we present a case of a young adult woman with Evans syndrome treated with rituximab, complicated by the development of serum sickness, acute respiratory distress syndrome, and platelet refractoriness presumed secondary to neutralizing antibodies to rituximab. Read More

High Alt Med Biol 2022 Apr 27. Epub 2022 Apr 27.

Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Uber, Amy, and Claire Twark. Symptom overlap of acute mountain sickness and lithium toxicity: a case report. 00:000-000, 2022. Read More

Br J Haematol 2022 Apr 17. Epub 2022 Apr 17.

Department of Haematology, University College Hospitals London NHS Foundation Trust, London, UK.

Rituximab, an anti-CD20 monoclonal antibody, can be used to treat immune thrombotic thrombocytopenic purpura (iTTP) during acute presentation or disease relapse. Undesirable side-effects include severe hypersensitivity reactions, particularly anaphylaxis and rituximab-induced serum sickness, with a minority not maintaining a response to treatment. Alternative humanised anti-CD20 treatments, obinutuzumab and ofatumumab, have been used. Read More

Front Vet Sci 2022 24;9:829060. Epub 2022 Mar 24.

Adaptation Physiology Group, Department of Animal Sciences, Wageningen University & Research, Wageningen, Netherlands.

Resilience, the capacity of animals to be minimally affected by a disturbance or to rapidly bounce back to the state before the challenge, may be improved by enrichment, but negatively impacted by a high allostatic load from stressful management procedures in pigs. We investigated the combined effects of diverging environmental conditions from weaning and repeated mixing to create high allostatic load on resilience of pigs. Pigs were either exposed to barren housing conditions (B) from weaning onwards or provided with sawdust, extra toys, regular access to a "play arena" and daily positive human contact (E). Read More

Curr Mol Pharmacol 2022 Mar 24. Epub 2022 Mar 24.

Department of Immunology, Bu-Ali Research Institute, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Background: Due to their plasticity, macrophages exert critical effects on both promoting and suppressing inflammatory processes. Pathologic inflammatory conditions are frequently correlated with dynamic alterations in macrophage activation, with classically activated M1 cells associated with promoting and sustaining inflammation and M2 cells implicated in resolution or smoldering chronic inflammation. Inflammation deputes a common feature from various chronic diseases and direct involvement in the insurgence and development of these conditions. Read More

Toxins (Basel) 2022 02 24;14(3). Epub 2022 Feb 24.

Evolutionary Venomics Lab, Centre for Ecological Sciences, Indian Institute of Science, Bangalore 560012, Karnataka, India.

Snake envenoming afflicts the Indian subcontinent with the highest rates of mortality (47,000) and morbidity globally. The only effective treatment for snakebites is the administration of antivenom, which is produced by the hyperimmunisation of equines. Commercial Indian antivenoms, however, have been shown to exhibit a poor preclinical performance in neutralising venom, as a result of inter- and intrapopulation snake venom variation. Read More

Antibodies (Basel) 2022 Feb 25;11(1). Epub 2022 Feb 25.

Kolling Institute of Medical Research, Royal North Shore Hospital of Sydney, Sydney, NSW 2065, Australia.

Identification of new disease-associated biomarkers; specific targeting of such markers by monoclonal antibodies (mAbs); and application of advances in recombinant technology, including the production of humanized and fully human antibodies, has enabled many improved treatment outcomes and successful new biological treatments of some diseases previously neglected or with poor prognoses. Of the 110 mAbs preparations currently approved by the FDA and/or EMA, 46 (including 13 antibody-drug conjugates) recognizing 29 different targets are indicated for the treatment of cancers, and 66, recognizing 48 different targets, are indicated for non-cancer disorders. Despite their specific targeting with the expected accompanying reduced collateral damage for normal healthy non-involved cells, mAbs, may cause types I (anaphylaxis, urticaria), II (e. Read More

Int Immunopharmacol 2022 Jun 14;107:108675. Epub 2022 Mar 14.

Beijing Institute of Basic Medical Sciences, Beijing 100850, China; Co-Innovation Center of Neuroregeneration, Nantong University, Nantong 226019, China; College of Life Sciences, Anhui Medical University, Hefei 230032, China; School of Pharmaceutical Sciences, University of South China, Hengyang 421001, China. Electronic address:

Background: Neuroinflammation caused by peripheral lipopolysaccharides (LPS) under hypoxia is a key contributor to the development of high altitude cerebral edema (HACE). Our previous studies have shown that gypenosides and their bioactive compounds prevent hypoxia-induced neural injuries in vitro and in vivo. However, their effect on neuroinflammation-related HACE remains to be illustrated. Read More

Front Cardiovasc Med 2022 25;9:832136. Epub 2022 Feb 25.

Department of Cardiology, The Sixth Medical Center of Chinese PLA General Hospital, Beijing, China.

Objective: Acute exposure to hypobaric hypoxia can trigger acute mountain sickness (AMS), while the exact mechanism has not been fully revealed. The role of genetic factors in the susceptibility of various high-altitude diseases has also gained much interest. Previous studies have provided evidence for the link between AMS and certain nuclear genes or mitochondrial haplogroup. Read More

Cureus 2022 Feb 4;14(2):e21910. Epub 2022 Feb 4.

Medical School, Universidad Internacional del Ecuador, Quito, ECU.

Snake bites (ophidism) constitute a public health problem in tropical and subtropical countries, due to their lethality, and the lack of access to prompt treatment in these regions. Catastrophic consequences follow the injection of the venom due to its proteolytic, procoagulant, hemorrhagic, nephrotoxic, vasculotoxic, and myonecrotizing properties, which can lead to severe complications if not managed promptly and adequately. In this report, we present the case of a 26-year-old male patient who suffered a snake bite (Bothrops asper) on the back of his right foot. Read More

J Vet Emerg Crit Care (San Antonio) 2022 Mar 2. Epub 2022 Mar 2.

Department of Small Animal Internal Medicine, The Veterinary Teaching Hospital, Koret School of Veterinary Medicine, The Hebrew University of Jerusalem, Rehovot, Israel.

Objective: To describe the successful treatment of a life-threatening type III hypersensitivity reaction suspected to have been related to human serum albumin (HSA) administration in a dog with therapeutic plasma exchange (TPE).

Case Summary: A 3-year-old neutered male mixed breed dog was suspected to have developed immune-mediated vasculitis 2 weeks after the administration of HSA (740 mg/kg) for the management of hypoalbuminemia resulting from septic peritonitis. The dog was presented with fever, edema, hypoalbuminemia (26 g/L [2. Read More

PeerJ 2022 24;10:e12977. Epub 2022 Feb 24.

Central Research Laboratory, Female Campus, King Saud University, Riyadh, Saudi Arabia.

Chronic diseases constitute a major global burden with significant impact on health systems, economies, and quality of life. Chronic diseases include a broad range of diseases that can be communicable or non-communicable. Chronic diseases are often associated with modifications of normal physiological levels of various analytes that are routinely measured in serum and other body fluids, as well as pathological findings, such as chronic inflammation, oxidative stress, and mitochondrial dysfunction. Read More

Int J Mol Sci 2022 Feb 21;23(4). Epub 2022 Feb 21.

Geriatrics Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA.

Systemic inflammation has been implicated in the progression of Alzheimer's disease (AD); however, less is understood about how existing AD pathology contributes to adverse outcomes following acute inflammatory insults. In the present study, our goal was to determine how AD-associated amyloid beta (Aβ) pathology influences the acute neuroinflammatory and behavioral responses to a moderate systemic inflammatory insult. We treated 16-18-month-old female Tg2576 (Tg) mice, which overproduce human Aβ and develop plaques, and age-matched wild-type (WT) littermate mice with an intraperitoneal injection of 0. Read More

Brain Behav Immun 2022 05 16;102:89-97. Epub 2022 Feb 16.

Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA; Department of Anesthesia, Critical Care & Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. Electronic address:

While COVID-19 research has seen an explosion in the literature, the impact of pandemic-related societal and lifestyle disruptions on brain health among the uninfected remains underexplored. However, a global increase in the prevalence of fatigue, brain fog, depression and other "sickness behavior"-like symptoms implicates a possible dysregulation in neuroimmune mechanisms even among those never infected by the virus. We compared fifty-seven 'Pre-Pandemic' and fifteen 'Pandemic' datasets from individuals originally enrolled as control subjects for various completed, or ongoing, research studies available in our records, with a confirmed negative test for SARS-CoV-2 antibodies. Read More

SAGE Open Med Case Rep 2021 31;9:2050313X21999206. Epub 2021 Mar 31.

District General Hospital, Kilinochchi, Sri Lanka.

Usually, bee sting systemic envenomation is self-limited mild allergic reaction rarely associated with systemic manifestations such as anaphylaxis, myocardial injury, encephalitis, acute kidney injury and serum sickness. Kounis syndrome also known as allergic myocardial infarction is uncommon clinical feature and reported cases are scarce in literature. Herein, we described a hypothetical case of Kounis syndrome diagnosed in a 74-year-old man initially presenting for anaphylactic reaction. Read More

J Ethnopharmacol 2022 May 4;290:115077. Epub 2022 Feb 4.

School of Life Sciences, Zhengzhou University, Zhengzhou, 450001, China. Electronic address:

Ethnopharmacological Relevance: As a common medicinal and edible plant, Zingiber officinale Roscoe (ginger) is often used for the prevention of motion sickness. However, the mechanism of its anti-motion sickness remains to be elucidated.

Aim Of The Study: To explore novel treatment for motion sickness with less side effects, anti-motion sickness effect of ginger (Zingiber officinale) extract (GE) and the possible molecular mechanisms were investigated. Read More

J Immunol Res 2022 20;2022:1737419. Epub 2022 Jan 20.

Department of Medicine, University at Buffalo, Buffalo, NY 14203, USA.

Complement factor H (FH) is a key regulator of the alternative pathway of complement, in man and mouse. Earlier, our studies revealed that the absence of FH causes the C57BL6 mouse to become susceptible to chronic serum sickness (CSS) along with an increase in the renal infiltration of macrophages compared to controls. To understand if the increased recruitment of macrophages (Ms) to the kidney was driving inflammation and propagating injury, we examined the effect of M depletion with clodronate in FH knockout mice with CSS. Read More

J Neuroimmunol 2022 03 14;364:577813. Epub 2022 Jan 14.

Schizophrenia Research Laboratory, Neuroscience Research Australia, Sydney, NSW 2031, Australia; School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, NSW 2052, Australia. Electronic address:

Maternal immune activation (MIA) with poly(I:C) is a preclinical paradigm for schizophrenia and autism research. Methodological variations, including poly(I:C) molecular weight, contribute to inconsistencies in behavioural and molecular outcomes. We established in Wistar rats that 4 mg/kg high molecular weight (HMW)-poly(I:C) on GD19 induces maternal sickness, smaller litters and maternal elevations of serum cytokines, including increases in monocyte chemoattractants. Read More

Neuromodulation 2021 Dec 18. Epub 2021 Dec 18.

Department of Gastroenterology, Changzheng Hospital, Naval Medical University, Shanghai, China. Electronic address:

Objectives: Motion sickness (MS) is a common physiological response to real or virtual motion. The purpose of this study was to investigate the effects of transcutaneous electrical acustimulation (TEA) on MS and the underlying mechanisms in healthy subjects.

Materials And Methods: A total of 50 healthy participants were recruited and randomly assigned into two groups to complete two separate sessions in a crossover study. Read More

Toxins (Basel) 2021 12 27;14(1). Epub 2021 Dec 27.

Clinical Research Department, Emergent BioSolutions Canada Inc., Winnipeg, MB R3T 5Y3, Canada.

Botulism is a rare, sometimes fatal paralytic illness caused by botulinum neurotoxins. BAT (Botulism Antitoxin Heptavalent (A, B, C, D, E, F, G)-(Equine)) is an equine-derived heptavalent botulinum antitoxin indicated for the treatment of symptomatic botulism in adult and pediatric patients. This review assesses the cumulative safety profile for BAT product from 2006 to 2020, using data received from clinical studies, an expanded-access program, a post-licensure registry, spontaneous and literature reports. Read More

Clin Nephrol 2022 May;97(5):298-304

Decompression sickness (DCS) occurs when divers are exposed to reduced barometric pressure during their ascent from depth. We report a case of DCS causing severe acute kidney injury (AKI) after an uneventful dive in which all decompression stops were made as instructed by a dive computer. A 26-year-old man presented with abdominal and bilateral flank pain ~ 24 hours after scuba diving to a depth of 23 m. Read More

Case Rep Med 2021 24;2021:3396373. Epub 2021 Dec 24.

Department of Emergency Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.

Reports of envenomation induced by , a medically important venomous snake in Taiwan, are rare, and species identification might not be definitive. This article reports the complete course of a definite bite. The patient in this report was one of the authors who was bitten on the right palm near the base of the index finger by The patient experienced local effects, neurological manifestations, and acute kidney injury. Read More

Sheng Li Xue Bao 2021 Dec;73(6):917-925

Department of Critical Care Medicine, Qinghai People's Hospital, Xining 810007, China.

The present study was aimed to observe the characteristics of sublingual microcirculation and the changes of humoral factors in healthy people of three different high altitude populations. Three groups of healthy subjects in Guoluo area of Qinghai province (4 100 m) were included: Tibetan group: 30 Tibetans, (45.62 ± 10. Read More

BMJ Case Rep 2021 Dec 22;14(12). Epub 2021 Dec 22.

Hematology, New York Oncology and Hematology, Albany, New York, USA.

Serum sickness (SS) is a known phenomenon; however, it is commonly missed due to vague symptoms, and is usually confounded by other aetiologies that present similarly. Obinutuzumab is a novel anti-CD20 antibody agent that has been approved for chronic lymphocytic leukaemia (CLL) treatment. At the time of approval, it was not linked to SS; however, this phenomenon has been recognised with other anti-CD20 agents like rituximab. Read More

Biomedica 2021 12 15;41(4):631-642. Epub 2021 Dec 15.

Grupo de Nutrición, Facultad de Salud, Universidad del Valle, Cali, Colombia.

We report two snakebites by Micrurus ortoni in Colombia and one by M. hemprichii in Perú. In two of the cases, we observed mild to moderate motor neurological involvement and in all patients, there was a marked sensory effect with hyperesthesia and hyperalgesia radiating from the bite site to the entire ipsilateral hemibody. Read More