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    The impact of anti-drug antibodies on drug concentrations and clinical outcomes in rheumatoid arthritis patients treated with adalimumab, etanercept, or infliximab: Results from a multinational, real-world clinical practice, non-interventional study.
    PLoS One 2017 27;12(4):e0175207. Epub 2017 Apr 27.
    Pfizer, Collegeville, Pennsylvania, United States of America.
    Objective: To assess the incidence of anti-drug antibodies (ADA) in patients with rheumatoid arthritis (RA) treated with the TNF inhibitors etanercept (ETN), adalimumab (ADL), or infliximab (IFX), and determine the potential relationship with trough drug concentration, efficacy, and patient-reported outcomes.

    Methods: This multi-national, non-interventional, cross-sectional study (NCT01981473) enrolled adult patients with RA treated continuously for 6-24 months with ETN, ADL, or IFX. ADA and trough drug concentrations were measured by independent assays ≤2 days before the next scheduled dose. Read More

    Opsoclonus myoclonus ataxia associated with West Nile virus infection: A dramatic presentation with benign prognosis?
    J Neurol Sci 2017 May 27;376:38-41. Epub 2017 Feb 27.
    Department of Neurology, Meir Medical Center, Kfar-Saba, Israel; Sackler Faculty of Medicine; Sagol School of Neuroscience, Tel Aviv University, Israel. Electronic address:
    Opsoclonus myoclonus and ataxia is a combination of severe neurological signs associated with several pathologic agents and conditions. Only few cases of opsoclonus have been related to West Nile virus infection. We report on a 61-year-old woman and on a 55-year-old man who had history of recent fever, who were hospitalized because of acute severe truncal ataxia, opsoclonus and tremor with minimal myoclonic jerks. Read More

    Evidence of African horse sickness virus infection of Equus zebra hartmannae in the south-western Khomas Region, Namibia.
    Transbound Emerg Dis 2017 Apr 12. Epub 2017 Apr 12.
    Unit for Environmental Sciences and Management, North-West University, Potchefstroom, South Africa.
    Equine mortalities suspected to be due to African horse sickness (AHS) were reported from the arid Khomas Region, Namibia, in 2008. The area was previously considered a localized AHS-free area. Hartmann's mountain zebra (Equus zebra hartmannae), a potential but unconfirmed reservoir host of African horse sickness virus (AHSV), occurs in the region. Read More

    Plasma cytokine profiling to predict susceptibility to acute mountain sickness.
    Eur Cytokine Netw 2016 Nov;27(4):90-96
    Key Laboratory of the plateau of environmental damage control, Lanzhou General Hospital of Lanzhou Military Command, Lanzhou, China.
    Extensive studies have been performed on acute mountain sickness (AMS), but biomarkers predicting AMS are lacking. Presently, the mainstay methods to identify AMS biomarkers include proteomic and genetic methods at high altitudes or in hypoxic simulated chambers. In the present study, we compared plasma cytokine profiles between AMS-susceptible individuals and AMS-resistant individuals at low altitude by cytokine array analysis. Read More

    Time Course of Endothelial Dysfunction Induced by Decompression Bubbles in Rats.
    Front Physiol 2017 23;8:181. Epub 2017 Mar 23.
    Department of Diving and Hyperbaric Medicine, Faculty of Naval Medicine, Second Military Medical University Shanghai, China.
    Decompression stress can cause endothelial injury, leading to systematic inflammation and prothrombotic phenomena. Our previous work found that endothelial injury following decompression correlated positively with bubble formation. This study aimed to investigate the time course of endothelial injury and the relationship with bubble amounts. Read More

    Effectiveness of conservative interventions for sickness and pain behaviors induced by a high repetition high force upper extremity task.
    BMC Neurosci 2017 Mar 29;18(1):36. Epub 2017 Mar 29.
    Department of Anatomy and Cell Biology, Temple University School of Medicine, 3500 North Broad St., Philadelphia, PA, 19140, USA.
    Background: Systemic inflammation is known to induce sickness behaviors, including decreased social interaction and pain. We have reported increased serum inflammatory cytokines in a rat model of repetitive strain injury (rats perform an upper extremity reaching task for prolonged periods). Here, we sought to determine if sickness behaviors are induced in this model and the effectiveness of conservative treatments. Read More

    Establishment and evaluation of an experimental rat model for high-altitude intestinal barrier injury.
    Exp Ther Med 2017 Feb 29;13(2):475-482. Epub 2016 Dec 29.
    Respiratory Department, Chengdu Military General Hospital, Chengdu, Sichuan 610083, P.R. China.
    In the present study an experimental high-altitude intestinal barrier injury rat model was established by simulating an acute hypoxia environment, to provide an experimental basis to assess the pathogenesis, prevention and treatment of altitude sickness. A total of 70 healthy male Sprague-Dawley rats were divided into two groups: Control group (group C) and a high-altitude hypoxia group (group H). Following 2 days adaptation, the rats in group H were exposed to a simulated 4,000-m, high-altitude hypoxia environment for 3 days to establish the experimental model. Read More

    Dynamics of African horse sickness virus nucleic acid and antibody in horses following immunization with a commercial polyvalent live attenuated vaccine.
    Vaccine 2017 Apr 22;35(18):2504-2510. Epub 2017 Mar 22.
    Equine Research Centre, Faculty of Veterinary Science, University of Pretoria, Onderstepoort, South Africa.
    African horse sickness (AHS) is a fatal disease of equids relevant to the global equine industry. Detection of AHS virus (AHSV) during outbreaks has become more rapid and efficient with the advent of group specific reverse transcriptase quantitative polymerase chain reaction (GS RT-qPCR) assays to detect AHSV nucleic acid. Use of GS RT-qPCR together with recently described type specific (TS RT-qPCR) assays cannot only expedite diagnosis of AHS but also facilitate further evaluation of the dynamics of AHSV infection in the equine host. Read More

    Alterations in amino acid status in cats with feline dysautonomia.
    PLoS One 2017 23;12(3):e0174346. Epub 2017 Mar 23.
    Royal (Dick) School of Veterinary Studies and The Roslin Institute, University of Edinburgh, Roslin, Midlothian, United Kingdom.
    Feline dysautonomia (FD) is a multiple system neuropathy of unknown aetiology. An apparently identical disease occurs in horses (equine grass sickness, EGS), dogs, rabbits, hares, sheep, alpacas and llamas. Horses with acute EGS have a marked reduction in plasma concentrations of the sulphur amino acids (SAA) cyst(e)ine and methionine, which may reflect exposure to a neurotoxic xenobiotic. Read More

    Neuroimmune mechanisms of behavioral alterations in a syngeneic murine model of human papilloma virus-related head and neck cancer.
    Psychoneuroendocrinology 2017 May 11;79:59-66. Epub 2017 Feb 11.
    Department of Symptom Research, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 384, Houston, TX 77030, USA.
    Patients with cancer often experience a high symptom burden prior to the start of treatment. As disease- and treatment-related neurotoxicities appear to be additive, targeting disease-related symptoms may attenuate overall symptom burden for cancer patients and improve the tolerability of treatment. It has been hypothesized that disease-related symptoms are a consequence of tumor-induced inflammation. Read More

    Divergent effects of brain interleukin-1ß in mediating fever, lethargy, anorexia and conditioned fear memory.
    Behav Brain Res 2017 May 14;324:155-163. Epub 2017 Feb 14.
    Brain Function Research Group, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, 7 York Road, Parktown, Johannesburg, South Africa. Electronic address:
    The influence of brain interleukin-1 (IL-1ß) on memory processes includes both detrimental and beneficial effects. To further explore the dynamics of brain IL-1ß in mediating learning and memory during acute sickness, we injected species-homologous rat IL-1ß (100ng/5μl) or vehicle (0.1% bovine serum albumin, 5μl) directly into the cisterna magna (i. Read More

    Role of Antioxidants in Horse Serum-mediated Vasculitis in Swine: Potential Relevance to Early Treatment in Mitigation of Coronary Arteritis in Kawasaki Disease.
    Pediatr Neonatol 2016 Dec 18. Epub 2016 Dec 18.
    Division of Pediatric Cardiology, Department of Pediatrics, National Taiwan University Children's Hospital, National Taiwan University, Taipei, Taiwan.
    Background: Horse serum-induced immune complex coronary vasculitis in swine is the first experimental model to mimic most of the pictures of Kawasaki disease. Immune complex mechanism has been implicated as one of the possible mechanisms in the pathogenesis of vasculitis in Kawasaki disease. Antioxidants have a significant role in the reduction of cardiovascular diseases in both human and animal studies. Read More

    Association of fatigue and depression with circulating levels of proinflammatory cytokines and epidermal growth factor receptor ligands: a correlative study of a placebo-controlled fatigue trial.
    Cancer Manag Res 2017 31;9:1-10. Epub 2017 Jan 31.
    The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
    Context: The biology of fatigue and depression in cancer patients is poorly understood. Hypotheses regarding cytokines and growth factors related to sickness behavior and disruption of circadian signaling have been proposed.

    Objectives: We prospectively examined proinflammatory cytokines (e. Read More

    Anti-Gal and anti-Neu5Gc responses in nonimmunosuppressed patients following treatment with rabbit anti-thymocyte polyclonal IgGs.
    Transplantation 2017 Feb 14. Epub 2017 Feb 14.
    1INSERM UMR 1064, Center for Research in Transplantation and Immunology, Nantes, France 2Société d'Accélération du Transfert de Technologies Ouest Valorisation, Rennes, France 3Xenothera, Nantes, France 4Biomarker Discovery Research, Immune Tolerance Network, Bethesda, MD, USA 5Institut de Transplantation-Urologie-Néphrologie (ITUN), Centre Hospitalier Universitaire de Nantes, France 6University of Nantes, France 7Clinical Trials Group, Immune Tolerance Network, San Francisco, CA, USA 8Division of Pediatric Endocrinology and Diabetes, University of California San Francisco, San Francisco, CA, USA.
    Background: Polyclonal anti-human thymocyte rabbit IgGs (anti-thymocyte globulin, ATG) are popular immunosuppressive drugs used to prevent or treat organ or bone-marrow allograft rejection, graft versus host disease, and autoimmune diseases. However, animal-derived glycoproteins are also strongly immunogenic and rabbit ATG induces serum sickness disease in almost all patients without additional immunosuppressive drugs, as seen in the START trial of ATG therapy in new-onset type 1 diabetes.

    Methods: Using ELISA, we analyzed serial sera from the START study to decipher the various anti-ATG specificities developed by the patients in this study: anti-total ATG, but also anti-galactose-α1-3-galactose (Gal) and anti-Neu5Gc antibodies, 2 xeno-carbohydrate epitopes present on rabbit IgG glycans and lacking in humans. Read More

    Endothelia-Targeting Protection by Escin in Decompression Sickness Rats.
    Sci Rep 2017 Jan 23;7:41288. Epub 2017 Jan 23.
    Department of Diving and Hyperbaric Medicine, Faculty of Naval Medicine, the Second Military Medical University, Shanghai, China.
    Endothelial dysfunction is involved in the pathogenesis of decompression sickness (DCS) and contributes substantively to subsequent inflammatory responses. Escin, the main active compound in horse chestnut seed extract, is well known for its endothelial protection and anti-inflammatory properties. This study aimed to investigate the potential protection of escin against DCS in rats. Read More

    Evaluation of antivenom therapy for Vipera palaestinae bites in children: experience of two large, tertiary care pediatric hospitals.
    Clin Toxicol (Phila) 2017 Apr 20;55(4):235-240. Epub 2017 Jan 20.
    a Division of Pediatric Emergency Medicine, Department of Pediatrics , Dana-Dwek Children Hospital, Sackler School of Medicine, University of Tel Aviv , Tel Aviv, Israel.
    Background: Antivenom has been successfully used to treat systemic and progressive, local manifestations of envenomation inflicted by Vipera (V.) palaestinae, the most common venomous snake in Israel. The objective of this study was to evaluate the fixed dose V. Read More

    In utero exposure to LPS alters the postnatal acute-phase response in beef heifers.
    Innate Immun 2017 Jan 21;23(1):97-108. Epub 2016 Nov 21.
    2 University of Florida, Range Cattle Research and Education Center, Ona, FL, USA.
    The potential effect of prenatal LPS exposure on the postnatal acute phase response (APR) to an LPS challenge in heifers was determined. Pregnant crossbred cows were separated into prenatal immune stimulation (PIS) and saline groups (Control). From these treatments, heifer calves were identified at weaning to subsequently receive an exogenous LPS challenge. Read More

    Serum sickness-like drug reaction: two cases with a neutrophilic urticarial pattern.
    J Cutan Pathol 2017 Feb 15;44(2):177-182. Epub 2016 Dec 15.
    Department of Dermatology, University of Minnesota, Minneapolis, MN, USA.
    The diagnosis of serum sickness-like reaction (SSLR) is typically based on clinical findings. Histopathologic examination is often deferred, as these eruptions commonly present in young children, and often to primary care providers. A PubMed literature search revealed only five existing cases of SSLR which describe cutaneous histopathologic features. Read More

    Carbohydrate Supplementation Influences Serum Cytokines after Exercise under Hypoxic Conditions.
    Nutrients 2016 Nov 5;8(11). Epub 2016 Nov 5.
    Department of Bioscience, Universidade Federal de São Paulo, Santos 11060-001, Brazil.
    Introduction: Exercise performed at the hypoxia equivalent of an altitude of 4200 m is associated with elevated inflammatory mediators and changes in the Th1/Th2 response. By contrast, supplementation with carbohydrates has an anti-inflammatory effect when exercise is performed under normoxic conditions. The objective of this study was to evaluate the effect of carbohydrate supplementation on cytokines and cellular damage markers after exercise under hypoxic conditions at a simulated altitude of 4200 m. Read More

    Hypercapnic ventilatory response is decreased in a mouse model of excessive erythrocytosis.
    Am J Physiol Regul Integr Comp Physiol 2016 Nov 7;311(5):R940-R947. Epub 2016 Sep 7.
    Centre de Recherche du CHU de Québec, Pavillon St François d'Assise, Département de Pédiatrie, Faculté de Médecine, Université Laval, Québec, QC, Canada;
    The impact of cerebral erythropoietin (Epo) in the regulation of the hypercapnic ventilatory response (HcVR) is controversial. While we reported that cerebral Epo does not affect the central chemosensitivity in C57Bl6 mice receiving an intracisternal injection of sEpoR (the endogenous antagonist of Epo), a recent study in transgenic mice with constitutive high levels of human Epo in brain and circulation (Tg6) and in brain only (Tg21), showed that Epo blunts the HcVR, maybe by interacting with central and peripheral chemoreceptors. High Epo serum levels in Tg6 mice lead to excessive erythrocytosis (hematocrit ~80-90%), the main symptom of chronic mountain sickness (CMS). Read More

    Anti-thymocyte globulins in kidney transplantation: focus on current indications and long-term immunological side effects.
    Nephrol Dial Transplant 2016 Oct 25. Epub 2016 Oct 25.
    Department of Nephrology, Charité Universitätsmedizin Berlin, 10117 Berlin, Germany.
    Antithymocyte globulins (ATGs) are part of the immunosuppression arsenal currently used by clinicians to prevent or treat acute rejection in solid organ transplantation. ATG is a mixture of non-specific anti-lymphocyte immunoglobulins targeting not only T cell subsets but also several other immune and non-immune cells, rendering its precise immunoglobulin composition difficult to appreciate or to compare from one preparation to another. Furthermore, several mechanisms of action have been described. Read More

    Clemens von Pirquet: A Remarkable Life and Career.
    J Pediatric Infect Dis Soc 2016 Oct 28. Epub 2016 Oct 28.
    Virginia H. Rogers Professor of Pediatric Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611.
    From 1908 to 1929, Clemens von Pirquet was one of the world's most acclaimed pediatricians. Von Pirquet (1874-1929) trained at Vienna's Universitäts Kinderklinic under Theodor Escherich, the first Pediatric Infectious Diseases physician [ 1], and became the first Professor and Chair of Pediatrics at Johns Hopkins in 1909. He then succeeded his mentor Escherich as Professor and Chair of Pediatrics in Vienna, the most prestigious European pediatric position, when Escherich died unexpectedly in 1911. Read More

    Probable metronidazole induced serum sickness-like reaction in a paediatric patient.
    J Clin Pharm Ther 2016 Dec 24;41(6):736-738. Epub 2016 Sep 24.
    Le Bonheur Children's Hospital, Memphis, TN, USA.
    What Is Known And Objective: Metronidazole (MTZ) is a commonly prescribed antibiotic and is generally well tolerated. To our knowledge, there has been only one case report linking MTZ with serum sickness-like reaction (SSLR).

    Case Summary: We report a probable case of SSLR following the administration of MTZ in a paediatric patient. Read More

    Development of a Microsphere-based Immunoassay for Serological Detection of African Horse Sickness Virus and Comparison with Other Diagnostic Techniques.
    Transbound Emerg Dis 2016 Dec 19;63(6):e270-e277. Epub 2015 Feb 19.
    VISAVET Health Surveillance Centre, Universidad Complutense de Madrid, Madrid, Spain.
    African horse sickness (AHS) is a viral disease that causes high morbidity and mortality rates in susceptible Equidae and therefore significant economic losses. More rapid, sensitive and specific assays are required by diagnostic laboratories to support effective surveillance programmes. A novel microsphere-based immunoassay (Luminex assay) in which beads are coated with recombinant AHS virus (AHSV) structural protein 7 (VP7) has been developed for serological detection of antibodies against VP7 of any AHSV serotype. Read More

    Serum sickness-like reaction after the treatment of cellulitis with amoxicillin/clavulanate.
    BMJ Case Rep 2016 Oct 18;2016. Epub 2016 Oct 18.
    Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
    Serum sickness-like reaction is a rare disease presentation. We describe a case of a man aged 58 years who presented with acute-onset polyarthralgia, intense pruritus of hands and feet, fever to 39.5°C and leucocytosis to 17. Read More

    The Protocol of Choice for Treatment of Snake Bite.
    Adv Med 2016 21;2016:7579069. Epub 2016 Sep 21.
    Toxicological Research Center, Department of Clinical Toxicology, Loghman-Hakim Hospital, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Department of Internal Medicine, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
    The aim of the current study is to compare three different methods of treatment of snake bite to determine the most efficient one. To unify the protocol of snake bite treatment in our center, we retrospectively reviewed files of the snake-bitten patients who had been referred to us between 2010 and 2014. They were contacted for follow-up using phone calls. Read More

    Reversible Brain Abnormalities in People Without Signs of Mountain Sickness During High-Altitude Exposure.
    Sci Rep 2016 Sep 16;6:33596. Epub 2016 Sep 16.
    Department of Physiology, Medical College of Xiamen University, Xiamen 361102, Fujian, China.
    A large proportion of lowlanders ascending to high-altitude (HA) show no signs of mountain sickness. Whether their brains have indeed suffered from HA environment and the persistent sequelae after return to lowland remain unknown. Thirty-one sea-level college students, who had a 30-day teaching on Qinghai-Tibet plateau underwent MRI scans before, during, and two months after HA exposure. Read More

    Development and evaluation of a new lateral flow assay for simultaneous detection of antibodies against African Horse Sickness and Equine Infectious Anemia viruses.
    J Virol Methods 2016 Nov 9;237:127-131. Epub 2016 Sep 9.
    Inmunología y Genética Aplicada S.A. (INGENASA), Madrid, Spain. Electronic address:
    African horse sickness (AHS) and equine infectious anemia (EIA) are both notifiable equid specific diseases that may present similar clinical signs. Considering the increased global movement of horses and equine products over the past decades, together with the socio-economic impact of previous AHS and EIA outbreaks, there is a clear demand for an early discrimination and a strict control of their transmission between enzootic and AHS/EIA-free regions. Currently, the individual control and prevention of AHS or EIA relies on a series of measures, including the restriction of animal movements, vector control, and the use of several laboratory techniques for viral identification, amongst others. Read More

    Inhibitory effects of Saussurea involucrata (Kar. et Kir.) Sch. -Bip. on adjuvant arthritis in rats.
    J Ethnopharmacol 2016 Dec 8;194:228-235. Epub 2016 Sep 8.
    Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China. Electronic address:
    Ethnopharmacological Relevance: Saussurea involucrate (Kar. et Kir.) Sch. Read More

    Caffeic acid attenuates lipopolysaccharide-induced sickness behaviour and neuroinflammation in mice.
    Neurosci Lett 2016 Oct 3;632:218-23. Epub 2016 Sep 3.
    Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal 576104, India; Menzies Health Institute Queensland, Griffith University, Gold Coast, Australia; School of Pharmacy, Griffith University, Gold Coast, Australia. Electronic address:
    Accumulating data links inflammation, oxidative stress and immune system in the pathophysiology of major depressive disorders. Sickness behaviour is a set of behavioural changes that develop during infection, eventually leading to decrease in mobility and depressed behaviour. Lipopolysaccharide (LPS) induces a depression-like state in animals that mimics sickness behaviour. Read More

    Fatigue in patients with erythema migrans.
    Diagn Microbiol Infect Dis 2016 Nov 27;86(3):322-326. Epub 2016 Jul 27.
    Baystate Medical Center, Springfield, MA 01199.
    Fatigue is a common symptom in patients with Lyme disease. The purpose of this study was to characterize fatigue in untreated adult patients presenting with erythema migrans. Selected variables were assessed to determine if any correlated with the presence or severity of fatigue. Read More

    [Second case of serum sickness-like reaction to claritrhomycin].
    Presse Med 2016 Nov 16;45(11):1056-1057. Epub 2016 Aug 16.
    CHU, université de Toulouse, faculté de médecine, service de médecine interne, place du Docteur Baylac TSA 40031, 31059 Toulouse cedex 9, France; Centre de recherches en cancérologie de Toulouse (CRCT), Institut national de la santé et de la recherche médicale (Inserm), UMR1037, 31000 Toulouse, France; Société de médecine chirurgie pharmacie, 31000 Toulouse, France.

    Immunosuppressive Therapy: Exploring an Underutilized Treatment Option for Myelodysplastic Syndrome.
    Clin Lymphoma Myeloma Leuk 2016 Aug;16 Suppl:S44-8
    H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.
    Background: Immunosuppressive therapy (IST) in low risk myelodysplastic syndrome (MDS) is known to achieve hematologic improvement but remains an underutilized treatment option. We report our experience using antithymocyte globulin (ATG) and cyclosporine A (CSA) to explore clinical predictive response factors.

    Patients And Methods: Patients treated with IST identified in the Moffitt Cancer Center MDS database were analyzed using baseline data, IST details, and response rates. Read More

    Renal disease in patients infected with hepatitis B virus.
    Trop Gastroenterol 2015 Oct-Dec;36(4):220-8
    Infection with hepatitis B virus (HBV) can result in hepatic diseases which may include an asymptomatic non-replicative carrier state, immunotolerant phase characterized by high DNA levels without significant hepatic injury, immune-reactive phase characterized by occurrence of chronic hepatitis and fibrosis in the liver, or complications like cirrhosis or hepatocellular carcinoma. Extrahepatic manifestations may also accompany HBV infection. These may include serum sickness syndrome, polyarthralgia, polyarthritis, dermatologic manifestations like pitted keratolysis, urticaria, purpura, oral lichen planus or Gianotti-Crosti syndrome-a childhood papular eruption. Read More

    Age and sex differences in immune response following LPS treatment in mice.
    Brain Behav Immun 2016 Nov 6;58:327-337. Epub 2016 Aug 6.
    School of Psychology, Faculty of Social Sciences, University of Ottawa, Canada. Electronic address:
    Puberty is an important developmental event that is marked by the reorganizing and remodeling of the brain. Exposure to stress during this critical period of development can have enduring effects on both reproductive and non-reproductive behaviors. The purpose of this study was to investigate age and sex differences in immune response by examining sickness behavior, body temperature changes, and serum cytokine levels following an immune challenge. Read More

    Systematic Analysis of the Cytokine and Anhedonia Response to Peripheral Lipopolysaccharide Administration in Rats.
    Biomed Res Int 2016 18;2016:9085273. Epub 2016 Jul 18.
    Neuroscience, Janssen Research & Development, Division of Janssen Pharmaceutica NV, Turnhoutseweg 30, 2340 Beerse, Belgium.
    Inflammatory processes may cause depression in subsets of vulnerable individuals. Inflammation-associated behavioral changes are commonly modelled in rodents by administration of bacterial lipopolysaccharide (LPS). However, the time frame in which immune activation and depressive-like behavior occur is not very clear. Read More

    Hypersensitivity and immunologic reactions to biologics: opportunities for the allergist.
    Ann Allergy Asthma Immunol 2016 Aug;117(2):115-20
    Department of Internal Medicine, Division of Allergy and Immunology, University of Texas Southwestern Medical Center, Dallas, Texas. Electronic address:
    Objective: There has been a great expanse in the use of biological agents during the past decade. However, there are significant differences between biologics and typical pharmaceutical drugs. This review focuses on 3 separate types of adverse reactions to biologics, namely high cytokine reactions, hypersensitivity reactions, and secondary immunodeficiency. Read More

    A Primate APOL1 Variant That Kills Trypanosoma brucei gambiense.
    PLoS Negl Trop Dis 2016 Aug 5;10(8):e0004903. Epub 2016 Aug 5.
    Wellcome Trust Centre for Molecular Parasitology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.
    Humans are protected against infection from most African trypanosomes by lipoprotein complexes present in serum that contain the trypanolytic pore-forming protein, Apolipoprotein L1 (APOL1). The human-infective trypanosomes, Trypanosoma brucei rhodesiense in East Africa and T. b. Read More

    Cerebral vasoconstriction reactions and plasma levels of ETBR, ET-1, and eNOS in patients with chronic high altitude disease.
    Mol Med Rep 2016 Sep 27;14(3):2497-502. Epub 2016 Jul 27.
    Department of Pathology, Qinghai Provincial People's Hospital, Xining, Qinghai 810007, P.R. China.
    The aim of the present study was to examine cerebral vasoconstriction in patients with chronic high altitude disease [cerebrovascular reactivity (CVR)], and to evaluate differences in alterations of brain vascular contractile reactivity of chronic mountain sickness (CMS) patients and healthy controls. Alterations of endothelin (ET) and its receptor, as well as endothelial nitric oxide synthase (eNOS) levels in the plasma were examined to determine the cerebral reservation capacities in CMS patients. Transcranial Doppler ultrasound and carbon dioxide analysis methods were used to detect the CVR variances. Read More

    Sickness-Associated Anorexia: Mother Nature's Idea of Immunonutrition?
    Mediators Inflamm 2016 29;2016:8071539. Epub 2016 Jun 29.
    Department of Physiological Sciences, Private Bag X1, Matieland, Stellenbosch 7600, South Africa.
    During an infection, expansion of immune cells, assembly of antibodies, and the induction of a febrile response collectively place continual metabolic strain on the host. These considerations also provide a rationale for nutritional support in critically ill patients. Yet, results from clinical and preclinical studies indicate that aggressive nutritional support does not always benefit patients and may occasionally be detrimental. Read More

    Piperacillin-Tazobactam Induced Interstitial Nephritis, Hepatitis and Serum Sckness-Like Illness.
    J Ark Med Soc 2016 Jun;112(14):278-80
    Objective: To describe a patient who developed acute interstitial nephritis, hepatitis and serum sickness-like syndrome after receiving piperacillin-tazobactam (zosyn) therapy.

    Case Summary: A 30-year-old woman received a 7-day course of piperacillin-tazobactam as empiric treatment for pneumonia. The patient's kidney function worsened and she turned anuric needing dialysis. Read More

    Quantification of hypoglycin A as butyl ester.
    J Chromatogr B Analyt Technol Biomed Life Sci 2016 Sep 5;1029-1030:169-73. Epub 2016 Jul 5.
    Screening-Labor Hannover, Postbox 91 10 09, 30430 Hannover, Germany; Department of Clinical Chemistry, Hannover Medical School, Carl-Neuberg-Straße 1, 30625 Hannover, Germany.
    L-α-amino-methylenecyclopropyl propionic acid (Hypoglycin A, HGA) has been found to be the toxic compound in fruits of the Sapindaceae family causing acute intoxication when ingested as food or feed. Clinical symptoms are consistent with acquired multiple acyl-CoA dehydrogenase deficiency (MADD). Ultra performance liquid chromatography-tandem mass spectrometry was used to measure HGA after butylation. Read More

    Repeated rituximab-induced serum sickness with anaphylaxis.
    Rinsho Ketsueki 2016 Jun;57(6):771-3
    Department of Hematology, National Hospital Organization Nishigunma Hospital.
    We describe a patient who developed repeated rituximab-induced serum sickness (RISS) followed by anaphylaxis soon after the third administration of rituximab at relapse. A 65-year-old woman with Sjögren's syndrome and relapsed mucosal associated lymphoma tissue (MALT) lymphoma of the lung underwent rituximab monotherapy (375 mg/m(2)/week). Several days after the second exposure to rituximab, she developed a rash, fever, and arthralgia. Read More

    [Adverse ocular effects of vaccinations].
    Ophthalmologe 2016 Jul;113(7):615-22
    Institut für Virologie; Department für Medizinische Mikrobiologie und Hygiene, Universitätsklinikum Freiburg, Freiburg, Deutschland.
    Vaccinations are very effective measures for prevention of infections but are also associated with a long list of possible side effects. Adverse ocular effects following vaccination have been rarely reported or considered to be related to vaccinations. Conjunctivitis is a frequent sequel of various vaccinations. Read More

    Neonatal Bacillus Calmette-Guérin vaccination alleviates lipopolysaccharide-induced neurobehavioral impairments and neuroinflammation in adult mice.
    Mol Med Rep 2016 Aug 23;14(2):1574-86. Epub 2016 Jun 23.
    Department of Anatomy and Neurobiology, Zhongshan School of Medicine, Sun Yat‑Sen University, Guangzhou, Guangdong 510080, P.R. China.
    The Bacillus Calmette-Guérin (BCG) vaccine is routinely administered to human neonates worldwide. BCG has recently been identified as a neuroprotective immune mediator in several neuropathological conditions, exerting neuroprotection in a mouse model of Parkinson's disease and slowing the progression of clinically isolated syndrome in patients with multiple sclerosis. The immune system is significantly involved in brain development, and several types of neonatal immune activations exert influences on the brain and behavior following a secondary immune challenge in adulthood. Read More

    Acute Radiation Syndrome Severity Score System in Mouse Total-Body Irradiation Model.
    Health Phys 2016 Aug;111(2):134-44
    *Uniformed Services University (USU), Armed Forces Radiobiology Research Institute (AFRRI), Scientific Research Department, 8901 Wisconsin Avenue, Bethesda, MD 20889-5603; †United States Army Medical Command (MEDCOM), United States Army Medical Research Institute of Chemical Defense (USAMRICD), 3100 Ricketts Point Road, Aberdeen Proving Ground, MD 21010-5400.
    Radiation accidents or terrorist attacks can result in serious consequences for the civilian population and for military personnel responding to such emergencies. The early medical management situation requires quantitative indications for early initiation of cytokine therapy in individuals exposed to life-threatening radiation doses and effective triage tools for first responders in mass-casualty radiological incidents. Previously established animal (Mus musculus, Macaca mulatta) total-body irradiation (γ-exposure) models have evaluated a panel of radiation-responsive proteins that, together with peripheral blood cell counts, create a multiparametic dose-predictive algorithm with a threshold for detection of ~1 Gy from 1 to 7 d after exposure as well as demonstrate the acute radiation syndrome severity score systems created similar to the Medical Treatment Protocols for Radiation Accident Victims developed by Fliedner and colleagues. Read More

    Diagnosis and treatment of adrenal insufficiency including adrenal crisis: a Japan Endocrine Society clinical practice guideline [Opinion].
    Endocr J 2016 Sep 24;63(9):765-784. Epub 2016 Jun 24.
    Department of Endocrinology and Diabetes Mellitus, Faculty of Medicine, Fukuoka University, Fukuoa 814-0180, Japan.
    This clinical practice guideline of the diagnosis and treatment of adrenal insufficiency (AI) including adrenal crisis was produced on behalf of the Japan Endocrine Society. This evidence-based guideline was developed by a committee including all authors, and was reviewed by a subcommittee of the Japan Endocrine Society. The Japanese version has already been published, and the essential points have been summarized in this English language version. Read More

    Understanding the mechanisms in accelerated drug reactions.
    Curr Opin Allergy Clin Immunol 2016 Aug;16(4):308-14
    aAllergy Unit bResearch Laboratory, IBIMA-Regional University Hospital of Malaga-UMA, Malaga, Spain.
    Purpose Of Review: The purpose is to understand the underlying mechanisms of accelerated allergic reactions to drugs, defined here as reactions occurring between 1 and 24 h after drug intake.

    Recent Findings: Recent publications have shown that accelerated reactions are T cell-mediated, although an IgE mechanism cannot be ruled out in some cases.

    Summary: Classification of allergic reactions to drugs is complex. Read More

    Association between Serum Interleukin-17A Level and High-Altitude Deacclimatization Syndrome.
    Mediators Inflamm 2016 14;2016:1732352. Epub 2016 Apr 14.
    Department of Laboratory Medicine, North Sichuan Medical College, Nanchong, Sichuan 637000, China; Translational Medicine Research Center, North Sichuan Medical College, Nanchong, Sichuan 637000, China.
    High-altitude deacclimatization syndrome (HADAS) is emerging as a severe public health issue that threatens the quality of life of individuals who return to lower altitude from high altitude. In this study, we measured serum levels of SOD, MDA, IL-17A, IL-10, TNF-α, and HADAS score in HADAS subjects at baseline and 50th and 100th days and to evaluate the relationship between interleukins, including IL-17A, and HADAS. Our data showed that and the serum IL-17A levels and HADAS score decreased over time in the HADAS group, and serum IL-17A levels were significantly higher in the HADAS group at baseline and 50th day compared with controls (p < 0. Read More

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