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Front Immunol 2019 25;10:39. Epub 2019 Jan 25.

Institute of Biodiversity, Animal Health and Comparative Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.

Trypanosomiasis has been recognized as a scourge in sub-Saharan Africa for centuries. The disease, caused by protozoan parasites of the genus, is a major cause of mortality and morbidity in animals and man. Human African trypanosomiasis (HAT), or sleeping sickness, results from infections with or with accounting for over 95% of infections. Read More

Front Pharmacol 2018 18;9:1559. Epub 2019 Jan 18.

Department of Immunology of Infectious Diseases, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland.

Lymphoid interstitial pneumonia (LIP) is a rare lymphoproliferative disease. LIP in common variable immunodeficiency (CVID) was observed in a patient during immunomodulatory therapy after progression of the disease (i.e. Read More

Stress 2019 Jan 24:1-12. Epub 2019 Jan 24.

a Texas A&M AgriLife Research , Texas A&M University System , Overton , TX , USA.

The objective of this study was to assess the influence of prenatal stress (PNS) on innate immune responses to an endotoxin challenge in weaned bull calves. Altered innate immune response to lipopolysaccharide (LPS), as characterized by changes in a range of variables was hypothesized in PNS bull calves. Brahman cows (n = 96; 48 stressed by transportation at five stages of gestation and 48 Controls) produced 85 calves, from which 16 uncastrated male (bull) calves from each PNS and Control treatment were selected for an LPS challenge period. Read More

Allergy Asthma Clin Immunol 2019 17;15. Epub 2019 Jan 17.

3Department of Medicine, Western University, London, ON Canada.

Background: Omalizumab is a humanized monoclonal antibody widely used for treatment of persistent allergic asthma and antihistamine-refractory chronic urticaria. Immediate adverse events to omalizumab are well characterized. Delayed anaphylactoid and serum sickness-like reactions have also been described; however, their relationship to the drug remains uncertain, and the frequency is unknown. Read More

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2018 Dec;34(12):1125-1129

Institute of Animal Quarantine, Chinese Academy of Inspection and Quarantine, Beijing 100176, China. *Corresponding author, E-mail:

Objective To prepare the monoclonal antibody (mAb) against the African horsefever virus (AHSV) VP7 protein and to identify it. Methods mAbs were prepared by using baculovirus expressed VP7 protein in BALB/c mice, and the effect of mAb was detected by ELISA, indirect immunofluorescence assay (IFA), and AHSV positive serum blockade. Results Four mAb strains were selected, including 20A8, 28B3, 30G8 and 47E6, among which 47E6 had the best blocking effect. Read More

Pharmaceuticals (Basel) 2019 Jan 8;12(1). Epub 2019 Jan 8.

Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Faculty of Science, Universities 99, 3584 CG Utrecht, The Netherlands.

Juvenile idiopathic arthritis (JIA) represents joint inflammation with an unknown cause that starts before the age of 16, resulting in stiff and painful joints. In addition, JIA patients often report symptoms of sickness behavior. Recent animal studies suggest that proinflammatory cytokines produce sickness behavior by increasing the activity of indoleamine-2,3-dioxygenase (IDO) and guanosinetriphosphate⁻cyclohydrolase-1 (GTP⁻CH1). Read More

Chembiochem 2019 Jan 3. Epub 2019 Jan 3.

GERMANY.

Humans have evolved a natural immunity against Trypanosoma brucei infections, which is executed by two serum (lipo)protein complexes known as trypanolytic factors (TLF). Active TLF-ingredient is the primate-specific apolipoprotein L1 (ApoL1). The protein has a pore-forming activity that kills parasites by lysosomal and mitochondrial membrane fenestration. Read More

J Educ Health Promot 2018 27;7:147. Epub 2018 Nov 27.

Clinical Education Research Center, Zeinabieh Hospital, Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

Introduction: Hepatic sickness is a serious problem for human health. The researchers are interested in using medicinal plants including barberry to cure many of these sicknesses. In this study, the effect of hydroalcoholic extract of leaf on hepatic protection was assessed in rats. Read More

Fish Shellfish Immunol 2019 Mar 24;86:942-946. Epub 2018 Dec 24.

Universidad de Málaga, Departamento de Microbiología, 29071, Málaga, Spain. Electronic address:

The pathogenic bacteria Photobacterium damselae subsp. piscicida affects the development of Solea senegalensis culture. Vaccines made with inactivated cells have produced a relative protection against the sickness, however the administration of subcellular and purified antigens as vaccine could increase the effectiveness of the immune response. Read More

J Drugs Dermatol 2018 Dec;17(12):1338-1339

Rituximab is a chimeric anti-CD20 monoclonal antibody that is very effective in treating patients with pemphigus vulgaris. Though infrequent, the development of human anti-chimeric antibodies in patients receiving rituximab results in loss of efficacy. Ofatumumab is a second-generation fully-human anti-CD20 monoclonal antibody currently used to treat chronic lymphocytic leukemia. Read More

Diving Hyperb Med 2018 Dec;48(4):259-261

Department of Pulmonary Medicine, Kameda Medical Centre, Kamogawa, Chiba, Japan.

Immersion pulmonary oedema (IPE) is particularly associated with an excessive reaction to exercise and/or cold stress. IPE usually resolves without recompression therapy within a day or two. Herein we report a diver diagnosed with IPE, in whom symptoms persisted for five days. Read More

Dermatol Ther 2018 Dec 4:e12798. Epub 2018 Dec 4.

Department of Dermatology, Sexually Transmitted Diseases and Clinical Immunology, The University of Warmia and Mazury, Olsztyn, Poland.

Background: Platelet rich plasma procedure (PRP) is considered to be one of the safest aesthetic procedures. Adverse reactions after PRP administration are extreme rare.

Purpose: We present the patient with serum sickness disease (SSD) after PRP procedure. Read More

Brain Behav Immun 2019 Feb 23;76:215-222. Epub 2018 Nov 23.

INRA, Nutrition and Integrative Neurobiology (NutriNeuro), UMR 1286, 33076 Bordeaux, France; University of Bordeaux, Nutrition and Integrative Neurobiology (NutriNeuro), UMR 1286, 33076 Bordeaux, France. Electronic address:

Obesity is a major public health burden associated with neuropsychiatric comorbidities leading to social and occupational impairment. Given the growing prevalence of both obesity and mental disorders worldwide, understanding the risk factors of obesity-related neuropsychiatric comorbidities is crucial to develop preventive strategies and individualized treatments. Recent findings suggest that adiposity-driven inflammation contributes to neuropsychiatric comorbidities in obesity. Read More

J Proteomics 2018 Nov 7. Epub 2018 Nov 7.

Institute of Neuroepidemiology and Tropical Neurology, School of Medicine, CNRS FR 3503 GEIST, University of Limoges, INSERM UMR 1094 Tropical Neuroepidemiology, Limoges, France. Electronic address:

Human African trypanosomiasis (HAT) is a neglected tropical disease that is endemic in sub-Saharan Africa. Control of the disease has been recently improved by better screening and treatment strategies, and the disease is on the WHO list of possible elimination. However, some physiopathological aspects of the disease transmission and progression remain unclear. Read More

Evid Based Complement Alternat Med 2018 8;2018:4812639. Epub 2018 Oct 8.

Guangdong Pharmaceutical University, Guangzhou, Guangdong 510006, China.

Longhu Rendan (LHRD), a Chinese traditional compound medicine, has a remarkable treatment effect on motion sickness for about half a century. However, the role of LHRD in atherosclerosis treatment is still unclear. In this study, LHRD treatment significantly diminished total cholesterol (TC), triglyceride (TG), and low-density lipoprotein cholesterol (LDL-C) levels in apolipoprotein E gene-knockout (ApoE) mice fed with high fat and high cholesterol diet (western diet). Read More

J Pharm Biomed Anal 2019 Feb 28;164:41-46. Epub 2018 Sep 28.

University of Minnesota, Department of Pharmaceutics, College of Pharmacy, Minneapolis, MN United States. Electronic address:

Scopolamine is an anticholinergic alkaloid that is widely used in the form of a transdermal system to manage nausea associated with motion sickness. Currently available methods to quantify scopolamine require large sample volumes and involve cumbersome sample preparation. In this work, a simple method for the rapid separation and sensitive quantification of scopolamine in human serum was developed. Read More

J Clin Rheumatol 2018 Oct 23. Epub 2018 Oct 23.

Department of Internal Medicine University of Texas at Austin Austin, TX Division of Rheumatology University of Washington Seattle, WA.

High Alt Med Biol 2018 Dec 24;19(4):373-381. Epub 2018 Oct 24.

1 Department of Infectious Disease, Kunming General Hospital of Chengdu Military Command, Kunming, China.

Objective: Clinical studies have shown that oral vitamin C supplementation can reduce serum uric acid levels in multiple populations and may also improve acute mountain sickness. However, it is unclear whether this protocol can improve high-altitude hyperuricemia. Therefore, we aimed to evaluate the role of vitamin C supplementation on high-altitude hyperuricemia. Read More

Dermatol Ther 2019 Jan 20;32(1):e12774. Epub 2018 Nov 20.

Assistance Publique- Hôpitaux de Paris, Département de Dermatologie, Hôpital Saint-Louis, Paris, France.

Non-peristomal postoperative pyoderma gangrenosum (PPG) is a rare subtype of pyoderma gangrenosum that occurs in the early postoperative period at surgical incisions, most commonly after breast surgery. Early diagnosis and treatment is essential to prevent severe scaring. TNF-alpha inhibitor infliximab was reported to be efficient in treatment of PPG refractory to systemic corticosteroids. Read More

Neurotoxicology 2019 01 16;70:26-32. Epub 2018 Oct 16.

Health Effects Laboratory Division, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV, USA. Electronic address:

Gulf War Illness (GWI) is a chronic multi-symptom disorder experienced by as many as a third of the veterans of the 1991 Gulf War; the constellation of "sickness behavior" symptoms observed in ill veterans is suggestive of a neuroimmune involvement. Various chemical exposures and conditions in theater have been implicated in the etiology of the illness. Previously, we found that GW-related organophosphates (OPs), such as the sarin surrogate, DFP, and chlorpyrifos, cause neuroinflammation. Read More

J Biochem Mol Toxicol 2018 Dec 1;32(12):e22224. Epub 2018 Oct 1.

Centre of Advanced Studies in Crystallography and Biophysics, University of Madras, Guindy Campus, Chennai, Tamil Nadu, India.

Classical antivenom therapy is unable to shield complications of viper bite and has limitations such as anaphylaxis and serum sickness. Snake venom metalloproteinases are responsible for local tissue damage and hemorrhage at the bitten site in viper envenomation, and this has led to a persistent search for metalloproteinase inhibitors. Here, we report the inhibitory effects of ascorbic acid against metalloproteinase from Echis carinatus venom both in-silico and in-vitro. Read More

J Cachexia Sarcopenia Muscle 2018 Dec 30;9(6):1109-1120. Epub 2018 Sep 30.

Department of Health Sciences, Boston University, Boston, MA, 02215, USA.

Background: Cancer cachexia is a metabolic wasting syndrome that is strongly associated with a poor prognosis. The initiating factors causing fat and muscle loss are largely unknown. Previously, we found that leukaemia inhibitory factor (LIF) secreted by C26 colon carcinoma cells was responsible for atrophy in treated myotubes. Read More

eNeuro 2018 Jul-Aug;5(4). Epub 2018 Aug 29.

Department of Physiology, University of Saskatchewan, Saskatoon S7N 5E5, Saskatchewan, Canada.

Influenza during pregnancy is associated with the development of psychopathology in the offspring. We sought to determine whether maternal cytokines produced following administration of viral mimetic polyinosinic-polycytidylic acid (polyI:C) to pregnant rats were predictive of behavioral abnormalities in the adult offspring. Timed-pregnant Sprague Dawley rats received a single intravenous injection of 4-mg/kg polyI:C or saline on gestational day (GD)15. Read More

Mult Scler Relat Disord 2018 Nov 11;26:52-54. Epub 2018 Sep 11.

Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI), University of Genoa, Italy; Ospedale Policlinico San Martino IRCCS, Genoa, Italy; Center of Excellence for Biomedical Research (CEBR), University of Genoa, Genoa, Italy.

Background: Alemtuzumab is a monoclonal antibody approved for relapsing-remitting multiple sclerosis (RRMS). The only report of Serum Sickness (SS) in a MS patient occurred during treatment with natalizumab. Non-protein drugs, such as some antibiotics, may induce "SS-like" reactions (SSLR), whose clinical and laboratory features may partially overlap with the traditional SS. Read More

Diving Hyperb Med 2018 Sep;48(3):197

Corresponding author: The Israel Naval Medical Institute, Israel Defence Forces Medical Corps, Haifa, Israel; Eliachar Research Laboratory, Western Galilee Medical Centre, Nahariya, Israel, 12 Klil-Hakhoresh, Rakefet, D.N. Misgav 2017500, Israel,

In a study of the effect of a fatty diet on decompression bubbles, based on the responses to a questionnaire regarding daily food consumption, the approximate fat intake for each diver was calculated, taking into account the maximum recommended intake for a person doing his type of work. Following hyperbaric exposure, divers were divided into two groups: 'bubblers' (a minimum of the second level on the Kisman-Masurel scale) and 'non-bubblers'. Bubblers had higher fat consumption than non-bubblers (146 ± 39% versus 92 ± 18%). Read More

Int J Dev Neurosci 2018 Dec 27;71:94-104. Epub 2018 Aug 27.

School of Psychology, Faculty of Social Sciences, University of Ottawa, Canada. Electronic address:

Puberty is a critical developmental period that is characterized by significant brain development. Exposure to stress during this time can alter brain functioning setting the stage for long-lasting behavioural outcomes. The objective of this study was to investigate age and sex differences in the peripheral and central immune responses, along with sickness behaviour, following immune stress. Read More

Rev Sci Tech 2017 Dec;36(3):889-898

African horse sickness virus (AHSV) is one of the most devastating viral diseases of the family Equidae. Infection with AHSV threatens not only the Saudi equine industry but also the equine industry worldwide. This is due to the high morbidity and mortality rates among the infected population of up to 100%. Read More

Eur J Oral Implantol 2018 ;11 Suppl 1:S37-S46

Aim: To describe general observations of immunological reactions to foreign materials and to realize that CP titanium gives rise to a foreign body reaction with subsequent bone embedment when placed as oral implants. To analyse the possibility of titanium allergy.

Materials And Methods: The present paper is of a narrative review type. Read More

Medicine (Baltimore) 2018 Aug;97(32):e11788

Department of Transfusion Medicine.

Background: Acute mountain sickness (AMS) is common in high-altitude travelers, and may lead to life-threatening high-altitude cerebral edema (HACE) or high-altitude pulmonary edema (HAPE). The inhaled drugs have a much lower peak serum concentrations and a shorter half-life period than oral drugs, which give them a special character, greater local effects in the lung. Meanwhile, short-term administration of inhaled drugs results in almost no adverse reactions. Read More

Transbound Emerg Dis 2019 Jan 2;66(1):83-90. Epub 2018 Aug 2.

The Pirbright Institute, Pirbright, UK.

The laboratory diagnosis of African horse sickness (AHS) is important for: (a) demonstrating freedom from infection in a population, animals or products for trade (b) assessing the efficiency of eradication policies; (c) laboratory confirmation of clinical diagnosis; (d) estimating the prevalence of AHS infection; and (e) assessing postvaccination immune status of individual animals or populations. Although serological techniques play a secondary role in the confirmation of clinical cases, their use is very important for all the other purposes due to their high throughput, ease of use and good cost-benefit ratio. The main objective of this study was to support the validation of AHS VP7 Blocking ELISA up to the Stage 3 of the World Animal Health Organization (OIE) assay validation pathway. Read More

Drug Res (Stuttg) 2018 Jul 31. Epub 2018 Jul 31.

Department of Pharmacology & Therapeutics, College of Medicine, University of Ibadan, Ibadan, Nigeria.

Purpose: L. leaves has been traditionally used for management of febrile illnesses and symptoms typified of sickness behavior. In this work we investigated the modulatory effect of flavonoid-rich fraction of leaves (EAFO) on sickness behavior, inflammatory and oxidative stress responses in LPS-challenged mice. Read More

Br J Dermatol 2018 Jul 12. Epub 2018 Jul 12.

Department of Dermatology, University Hospital Zealand, Sygehusvej 5, 4000, Roskilde, Denmark.

Background: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease characterized by recurrent inflamed nodules. No pathognomonic test is available for HS; hence the diagnosis is based on three clinical criteria.

Objectives: To estimate the cross-sectional prevalence and characterize patients with HS in the Danish Blood Donor Study cohort. Read More

Chem Sci 2018 Jun 10;9(22):4942-4949. Epub 2018 May 10.

College of Chemistry, Chemical Engineering and Materials Science , Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong , Key Laboratory of Molecular and Nano Probes , Ministry of Education , Shandong Provincial Key Laboratory of Clean Production of Fine Chemicals , Shandong Normal University , Jinan 250014 , China . Email: ; ; Tel: +86 0531 86186033.

Human T-lymphotropic virus type II (HTLV-II) is an important type-C retrovirus, closely related to a variety of human diseases. Here, we demonstrate for the first time the controllable fabrication of bio-bar codes for dendritically amplified sensing of low-abundant HTLV-II DNA by the integration of terminal deoxynucleotidyl transferase (TdT)-catalyzed template-free polymerization extension with bio-bar-code amplification (BCA). HTLV-II DNA hybridizes with magnetic microparticle (MMP)-modified capture probe 1, forming a stable DNA duplex with a protruding 3'-hydroxylated sequence which may function as a primer to initiate the TdT-catalyzed first-step polymerization extension for the generation of a poly-thymidine (T) sequence. Read More

J Cell Biochem 2018 Nov 22;119(10):8336-8345. Epub 2018 Jun 22.

The Third Hospital of Heilongjiang Province, Beian, P.R. China.

Minimal hepatic encephalopathy (MHE), a complex neuropsychological complication of cirrhosis, is characterized by delayed reaction time and the inhibition of abnormal response. This network meta-analysis (NMA) was adopted to compare the efficacy of five drugs including lactulose, probiotics, rifaximin, acetyl-L-carnitine (ALC), and L-Ornithine L-aspartate (LOLA) in the treatment of MHE. The Cochrane Library, PubMed, and Embase databases were searched for any existing entail on these five drugs from the inception to February 2018, including Randomized controlled trials (RCTs). Read More

J Pediatr Gastroenterol Nutr 2018 Nov;67(5):616-621

Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Northwestern Feinberg School of Medicine, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL.

Objective: Fatigue is common among patients with inflammatory bowel disease (IBD). Proinflammatory cytokines are elevated in chronic inflammation and can induce "sickness behaviors," such as fatigue. Chronic inflammatory states also lead to growth hormone resistance, demonstrated by low levels of insulin-like growth factor (IGF-1) and elevated growth hormone. Read More

High Alt Med Biol 2018 Sep 21;19(3):221-231. Epub 2018 May 21.

1 Laboratorio de Fisiología Comparada, Departamento de Ciencias Biológicas y Fisiológicas, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia. Lima , Perú.

Corante, Noemí, Cecilia Anza-Ramírez, Rómulo Figueroa-Mujíca, José Luis Macarlupú, Gustavo Vizcardo-Galindo, Grzegorz Bilo, Gianfranco Parati, Jorge L. Gamboa, Fabiola León-Velarde, and Francisco C. Villafuerte. Read More

Int Urol Nephrol 2018 Jul 4;50(7):1329-1339. Epub 2018 May 4.

West China Nursing School/West China Hospital, Sichuan University, Chengdu, 610061, Sichuan, China.

Purpose: The purpose of the study was to investigate the major factors affecting fatigue symptoms and to examine the relationships between fatigue symptoms and subjective and objective indicators in patients on hemodialysis (HD).

Methods: Patients on HD who met the inclusion criteria were chosen from two grade A tertiary general hospitals by convenience sampling and cross-sectional survey methods.

Results: A total of 511 patients were included in the study. Read More

Res Vet Sci 2018 Jun 14;118:419-422. Epub 2018 Apr 14.

U.S. Meat Animal Research Center, U.S. Department of Agriculture, Clay Center, NE 68933, United States.

White snakeroot (Ageratina altissima) contains the putative toxin tremetone and can produce a disease called "trembles" or "milk sickness". However the toxicity of tremetone has not been demonstrated in vivo. It has been reported that the plant is less toxic after drying and grinding. Read More

Ned Tijdschr Geneeskd 2018;162:D2251

Westfriesgasthuis, afd. Kindergeneeskunde en Neonatologie, Hoorn.

Background: Urticaria multiforme is a rare clinical variant of urticaria that occurs specifically in children.

Case Description: A boy aged 11 months was presented at the Emergency Department with acute onset of itching urticarial skin weals and acral oedema. This picture is consistent with the diagnosis of urticaria multiforme. Read More

High Alt Med Biol 2018 06 2;19(2):170-177. Epub 2018 Apr 2.

1 Department of Clinical Laboratory, People's Liberation Army General Hospital , Beijing, China .

Wang, Chi, Hui Jiang, Jinyan Duan, Jingwen Chen, Qi Wang, Xiaoting Liu, and Chengbin Wang. Exploration of acute phase proteins and inflammatory cytokines in early stage diagnosis of acute mountain sickness. High Alt Med Biol. Read More

Porcine Health Manag 2018 6;4. Epub 2018 Mar 6.

1Faculty of Veterinary Medicine, University of Helsinki, Paroninkuja 20, 04920 Saarentaus, FI Finland.

Background: Infection with respiratory pathogens can influence production as well as animal welfare. There is an economical and ethical need to treat pigs that suffer from respiratory diseases. Our aim was the evaluation of the possible effects of oral NSAID medication given in feed in acute outbreaks of respiratory disease in finishing pigs. Read More

Front Physiol 2018 1;9:64. Epub 2018 Mar 1.

EA4324 ORPHY, Institut Brestois Santé Agro Matière, Université de Bretagne Occidentale, Brest, France.

Commercial divers, high altitude pilots, and astronauts are exposed to some inherent risk of decompression sickness (DCS), though the mechanisms that trigger are still unclear. It has been previously showed that diving may induce increased levels of serum angiotensin converting enzyme. The renin angiotensin aldosterone system (RAAS) is one of the most important regulators of blood pressure and fluid volume. Read More

Br J Haematol 2018 Mar 12. Epub 2018 Mar 12.

Department of Haematology, University College London Hospital, Cardiometabolic Programme-NIHR UCLH/UCL BRC, London, UK.

Brain Behav Immun 2018 05 7;70:257-267. Epub 2018 Mar 7.

Department of Psychology and Neuroscience, University of Colorado, Boulder, CO 80309, USA.

Exposure to stressors can enhance neuroinflammatory responses, and both stress and neuroinflammation are predisposing factors in the development of psychiatric disorders. Females suffer disproportionately more from several psychiatric disorders, yet stress-induced changes in neuroinflammation have primarily been studied in males. Here we tested whether exposure to inescapable tail shock sensitizes or 'primes' neuroinflammatory responses in male and female rats. Read More

Pediatr Allergy Immunol 2018 06 15;29(4):449-450. Epub 2018 Apr 15.

Division of Pulmonary, Department of Pediatrics, Allergy and Sleep Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.

Acupunct Med 2018 Jun 7;36(3):153-161. Epub 2018 Feb 7.

Department of Ship Hygiene, Faculty of Navy Medicine, Second Military Medical University, Shanghai, China.

Objective: Acupuncture has been widely used for the treatment of motion sickness (MS), but the underlying mechanisms are unclear. The aim of this research was to study the mechanism of acupuncture in the treatment of MS.

Methods: To observe the effects of acupuncture in the treatment of MS, 80 rats were randomised into five groups that were subjected to acceleration and either remained untreated (CTRL), or received restraint (REST), scopolamine (SCOP) or acupuncture at SP4 (sham) or PC6+ST36 (verum) acupuncture points. Read More

Mol Immunol 2018 03 20;95:91-98. Epub 2018 Feb 20.

Center of Cardiovascular Surgery, General Hospital of Guangzhou Military Command of PLA, Guangzhou, Guangdong 510010, PR China. Electronic address:

High altitude cerebral edema (HACE) is a severe type of acute mountain sickness (AMS) that occurs in response to a high altitude hypobaric hypoxic (HH) environment. GM1 monosialoganglioside can alleviate brain injury under adverse conditions including amyloid-β-peptide, ischemia and trauma. However, its role in HACE-induced brain damage remains poorly elucidated. Read More

Clin Kidney J 2018 Feb 10;11(1):51-53. Epub 2017 Aug 10.

Department of Nephrology, Western Health, Footscray, VIC, Australia.

We report a case of rituximab-induced serum sickness in a 50-year-old female with idiopathic membranous nephropathy. Presentation was characterized by a widespread rash 1 week after rituximab administration followed by fever and profound haemodynamic instability, mimicking sepsis. Symptoms resolved over 48 h, although adjunct antibiotics, steroids and inotropes were used. Read More

Nat Microbiol 2018 Mar 22;3(3):295-301. Epub 2018 Jan 22.

Department of Biochemistry, University of Oxford, Oxford, UK.

Only two trypanosome subspecies are able to cause human African trypanosomiasis. To establish an infection in human blood, they must overcome the innate immune system by resisting the toxic effects of trypanolytic factor 1 and trypanolytic factor 2 (refs. ). Read More