35,862 results match your criteria Septic Shock


Clinical characteristics of patients with severe sepsis and septic shock in relation to bacterial virulence of beta-hemolytic and .

Acute Med Surg 2020 Jan-Dec;7(1):e513. Epub 2020 May 31.

Division of Acute and Critical Care Medicine Hokkaido University Graduate School of Medicine Sapporo Japan.

Aim: Combined detailed analysis of patient characteristics and treatment as well as bacterial virulence factors, which all play a central role in the cause of infections leading to severe illness, has not been reported. We aimed to describe the patient characteristics (Charlson comorbidity index [CCI]), treatment (3-h bundle), and outcomes in relation to bacterial virulence of and beta-hemolytic (BHS).

Methods: This sepsis primary study is part of the larger Focused Outcomes Research in Emergency Care in Acute Respiratory Distress Syndrome, Sepsis and Trauma (FORECAST) study, a multicenter, prospective cohort study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ams2.513DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262430PMC

Use of hemoadsorption in sepsis-associated ECMO-dependent severe ARDS: A case series.

J Intensive Care Soc 2020 May 8;21(2):183-190. Epub 2019 Jan 8.

Department of Intensive Care Medicine, University Hospital Hamburg, Hamburg, Germany.

Introduction: Acute respiratory distress syndrome in the context of severe sepsis and septic shock represents a serious clinical disorder. A recent case series in patients with septic shock and renal failure receiving hemoadsorption treatment showed rapid hemodynamic stabilization and increased survival, particularly in pneumonia patients and in those where therapy was started early. We hypothesized that patients suffering from pneumonia and refractory acute respiratory distress syndrome to the extent that they required extracorporeal membrane oxygenation support could possibly demonstrate the most pronounced benefit from the treatment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1751143718818992DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238480PMC

Vasopressin in Patients with Septic Shock and Dynamic Left Ventricular Outflow Tract Obstruction.

Cardiovasc Drugs Ther 2020 Jun 2. Epub 2020 Jun 2.

Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, Unit of Anaesthesia and Intensive Care Fondazione Policlinico San Matteo, IRCCS, University of Pavia, Pavia, Italy.

Purpose: Left ventricular outflow tract obstruction (LVOTO) is a relatively uncommon but severe condition that may lead to hemodynamic impairment. It can be elicited by morphological (left ventricular hypertrophy, sigmoid septum, prominent papillary muscle, prolonged anterior mitral valve leaflet) and functional (hypovolemia, low afterload, hypercontractility, catecholamines) factors. We sought to determine the incidence of the most severe form of LVOTO in septic shock patients and describe the therapeutic effects of vasopressin. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10557-020-06998-8DOI Listing

Combined Timed Surgery and Conservative Management of Primary Necrotizing Fasciitis of the Breast: A Case Report.

Am J Case Rep 2020 Jun 3;21:e922688. Epub 2020 Jun 3.

Department of Public Health, Sector of Plastic Surgery, University of Naples "Federico II", Naples, Italy.

BACKGROUND Necrotizing fasciitis is a life-threatening infection that involves the deep fascia and the surrounding tissue, but rarely involves the female breast. The most common treatment for necrotizing fasciitis of the breast is total mastectomy. However, the use of negative pressure wound therapy (NPWT), after surgical debridement, is reported to promote the more rapid development of granulation tissue, before reconstructive surgery. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12659/AJCR.922688DOI Listing

Anticholinergic drug exposure at intensive care unit admission affects the occurrence of delirium. A prospective cohort study.

Eur J Intern Med 2020 May 30. Epub 2020 May 30.

Department of Intensive Care Medicine and UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands. Electronic address:

Background: Anticholinergic drugs may increase the risk of delirium in non-critically ill patients, but it is unclear whether exposure to these drugs is also a risk factor for Intensive Care Unit (ICU) delirium. In this study the hypothesis was tested that anticholinergic drug exposure at ICU admission increases the risk to develop delirium during ICU stay, particularly in patients with advanced age and severe sepsis.

Methods: A prospective cohort study was performed in the mixed 32-bed medical-surgical ICU of the University Medical Center Utrecht, the Netherlands in the period from January 2011 till June 2013. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejim.2020.04.062DOI Listing

Urine cell cycle arrest biomarkers distinguish poorly between transient and persistent AKI in early septic shock: a prospective, multicenter study.

Crit Care 2020 Jun 1;24(1):280. Epub 2020 Jun 1.

BoReal Study Group, Medical Intensive Care Unit and EA7517, Amiens University Hospital, F-80054, Amiens, France.

Background: The urine biomarkers tissue inhibitor of metalloproteinases-2 (TIMP-2) and insulin-like growth factor-binding protein 7 (IGFBP7) have been validated for predicting and stratifying AKI. In this study, we analyzed the utility of these biomarkers for distinguishing between transient and persistent AKI in the early phase of septic shock.

Methods: We performed a prospective, multicenter study in 11 French ICUs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13054-020-02984-6DOI Listing

[A meta-analysis to evaluate the effects of corticosteroids on the outcomes of patients with septic shock].

Authors:
Q Li J F Xie L Liu

Zhonghua Nei Ke Za Zhi 2020 Jun;59(6):451-459

Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, China.

To evaluate the effect of corticosteroids on the prognosis of patients with septic shock. In order to compare administration of corticosteroids with placebo or standard supportive care in adults with septic shock, clinical randomized controlled trials (RCT) were searched and selected, according to inclusion and exclusion criteria. A systemic assessment and meta-analysis was performed using RevMan 5. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3760/cma.j.cn112138-20190802-00536DOI Listing

Virulence Potential of a Multidrug-Resistant Strain Belonging to the Emerging Clonal Group ST101-B1 Isolated from Bloodstream Infection.

Microorganisms 2020 May 30;8(6). Epub 2020 May 30.

Disciplina de Microbiologia, Departamento de Microbiologia, Imunologia e Parasitologia-DMIP, Universidade Federal de São Paulo-Escola Paulista de Medicina (UNIFESP-EPM), São Paulo-SP 04023-062, Brazil.

Escherichia coli EC121 is a multidrug-resistant (MDR) strain isolated from a bloodstream infection of an inpatient with persistent gastroenteritis and T-zone lymphoma that died due to septic shock. Despite causing an extraintestinal infection, previous studies showed that it did not have the usual characteristics of an extraintestinal pathogenic Instead, it belonged to phylogenetic group B1 and harbored few known virulence genes. To evaluate the pathogenic potential of strain EC121, an extensive genome sequencing and in vitro characterization of various pathogenicity-associated properties were performed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/microorganisms8060827DOI Listing

The development an artificial intelligence algorithm for early sepsis diagnosis in the intensive care unit.

Int J Med Inform 2020 May 21;141:104176. Epub 2020 May 21.

Division of General Surgery, Department of Surgery, Taipei Medical University Hospital, Taipei, Taiwan; Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.

Background: Severe sepsis and septic shock are still the leading causes of death in Intensive Care Units (ICUs), and timely diagnosis is crucial for treatment outcomes. The progression of electronic medical records (EMR) offers the possibility of storing a large quantity of clinical data that can facilitate the development of artificial intelligence (AI) in medicine. However, several difficulties, such as poor structure and heterogenicity of the raw EMR data, are encountered when introducing AI with ICU data. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijmedinf.2020.104176DOI Listing

Effects of a single dose of vitamin D in septic children: a randomized, double-blinded, controlled trial.

J Int Med Res 2020 Jun;48(6):300060520926890

Department of Pediatrics, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, Henan, China.

Objective: To assess the effects of a single dose of vitamin D on 25-hydroxyvitamin D (25OHD) levels and clinical outcomes in children with vitamin D deficiency (VDD) and sepsis.

Methods: In this randomized, controlled trial, eligible children with VDD and sepsis were assigned to receive one dose of 150,000 IU of cholecalciferol or placebo. Serum concentrations of 25OHD, angiotensin-II (Ang-II), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) were assessed at baseline and 8 days after treatment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0300060520926890DOI Listing

Vitamin C, Hydrocortisone, and Thiamine for Septic Shock-In Reply.

JAMA 2020 Jun;323(21):2204-2205

Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/jama.2020.5850DOI Listing

Vitamin C, Hydrocortisone, and Thiamine for Septic Shock.

JAMA 2020 Jun;323(21):2203-2204

Department of Medicine, Eastern Virginia Medical School, Norfolk.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/jama.2020.5844DOI Listing

Delta Lactate (Three-hour Lactate Minus Initial Lactate) Prediction of In-hospital Death in Sepsis Patients.

Cureus 2020 Apr 27;12(4):e7863. Epub 2020 Apr 27.

Emergency Medicine, Envision Physician Services, Nashville, USA.

This study examines the relationship between serial serum lactate levels and in-hospital mortality in an adult cohort of emergency department patients with severe sepsis or septic shock. Of the 164 patients in the cohort, 130 also got three-hour lactate in addition to the initial one. The median initial lactate was 3. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7759/cureus.7863DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255083PMC

Successful outcomes of endoscopic lithotripsy in completely bedridden patients with symptomatic urinary calculi.

Sci Rep 2020 Jun 1;10(1):8839. Epub 2020 Jun 1.

Department of Urology, Kidney Stone Center, Tokyo Metropolitan Ohtsuka Hospital, 2-8-1 Minami-Ohtsuka, Toshima-ku, Tokyo, Japan.

Due to the aging population, the number of completely bedridden individuals is expected to increase, and such individuals are at high risk of developing urinary calculi. This retrospective study included 32 consecutive bedridden patients, who had undergone endoscopic lithotripsy between 2010 and 2019, and aimed to identify the treatment outcomes of endoscopic lithotripsy for bedridden patients. A total of 45 endoscopic lithotripsies were performed to treat stones (median cumulative diameter, 24 mm). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-020-65807-2DOI Listing

Vitamin C in Health and Disease: A Companion Animal Focus.

Top Companion Anim Med 2020 Jun 8;39:100432. Epub 2020 Apr 8.

Departments of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus OH, USA. Electronic address:

Vitamin C is synthesized in the liver in most species, including dogs and cats, and is widely distributed through body tissues. Vitamin C has an important physiologic role in numerous metabolic functions including tissue growth and maintenance, amelioration of oxidative stress, and immune regulation. It is also a co-factor in the production of important substances such as catecholamines and vasopressin. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tcam.2020.100432DOI Listing

Biomarker combination and SOFA score for the prediction of mortality in sepsis and septic shock: A prospective observational study according to the Sepsis-3 definitions.

Medicine (Baltimore) 2020 May;99(22):e20495

Medical Science Research Center, Korea University Ansan Hospital, Ansan, Republic of Korea.

Biomarkers are valuable tools for the prediction of mortality in patients with sepsis. However, the use of a single biomarker to predict patient outcomes is challenging owing to the complexity and redundancy of the immune response to infections.We aimed to conduct a prospective observational analysis to investigate the prognostic value of pentraxin 3, interleukin 6, procalcitonin, and lactate combined in predicting the 28-day mortality rate in patients with sepsis or septic shock (n = 160; sepsis, 78; sepsis shock, 82). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000020495DOI Listing

rs12980275 Polymorphism Predicts Septic Shock-Related Death in Patients Undergoing Major Surgery: A Retrospective Study.

Front Med (Lausanne) 2020 14;7:186. Epub 2020 May 14.

Unidad de Infección Viral e Inmunidad, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Spain.

Interferon lambda 3 (IFNL3, previously called IL-28B) is a cytokine with effects against viral and bacterial pathogens. We aimed to analyze the rs12980275 SNP in patients who underwent major surgery, in order to establish its relationship with susceptibility to septic shock and septic shock-related death in these patients. We performed a case-control study on 376 patients to establish the association between rs12980275 SNP and the susceptibility to develop septic shock. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fmed.2020.00186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239994PMC

The Role of Glucocorticoid Receptor and Oxytocin Receptor in the Septic Heart in a Clinically Relevant, Resuscitated Porcine Model With Underlying Atherosclerosis.

Front Endocrinol (Lausanne) 2020 14;11:299. Epub 2020 May 14.

Ulm University Medical Center, Institute for Anesthesiological Pathophysiology and Process Engineering, Ulm, Germany.

The pathophysiology of sepsis-induced myocardial dysfunction is not resolved to date and comprises inflammation, barrier dysfunction and oxidative stress. Disease-associated reduction of tissue cystathionine-γ-lyase (CSE) expression, an endogenous HS-producing enzyme, is associated with oxidative stress, barrier dysfunction and organ injury. CSE-mediated cardio-protection has been suggested to be related the upregulation of oxytocin receptor (OTR). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fendo.2020.00299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239997PMC

Near-fatal poisoning after ricin injection.

Clin Toxicol (Phila) 2020 Jun 1:1-11. Epub 2020 Jun 1.

Campinas Poison Control Center, School of Medical Sciences, University of Campinas (UNICAMP), Campinas, Brazil.

To report a near-fatal poisoning after intentional injection of ricin from a castor bean () extract. A 21 year-old man self-injected ∼3 mL of a castor bean extract intramuscularly and subcutaneously in the left antecubital fossa. Upon admission to our ED (1 h post-exposure; day 1, D1) he was awake and alert, but complained of mild local pain and showed slight local edema and erythema. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/15563650.2020.1771358DOI Listing

Continuous renal replacement therapy in cytokine release syndrome following immunotherapy or cellular therapies?

J Immunother Cancer 2020 May;8(1)

Research Center for Functional Genomics and Translational Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj Napoca, Romania

Recently, an increasing number of novel drugs were approved in oncology and hematology. Nevertheless, pharmacology progress comes with a variety of side effects, of which cytokine release syndrome (CRS) is a potential complication of some immunotherapies that can lead to multiorgan failure if not diagnosed and treated accordingly. CRS generally occurs with therapies that lead to highly activated T cells, like chimeric antigen receptor T cells or in the case of bispecific T-cell engaging antibodies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/jitc-2020-000742DOI Listing

Colistimethate sodium and acute kidney injury: Incidence, risk factors, outcome and prognosis of renal function.

Nefrologia 2020 May 27. Epub 2020 May 27.

Department of Nephrology, Hospital Universitario Ramón y Cajal, Madrid, Spain; Instituto Ramón y Cajal de Investigación Sanitaria (IRyCis), RedinRenISCIII (ERC 10 RD12/0021/0020), Madrid, Spain.

Background: Colistimethate sodium (CMS) treatment has increased over the last years, being acute kidney injury (AKI) its main drug-related adverse event. Therefore, this study aimed to evaluate the incidence and risk factors associated with AKI, as well as identifying the factors that determine renal function (RF) outcomes at six months after discharge.

Materials And Methods: This retrospective study included adult septic patients receiving intravenous CMS for at least 48h (January 2007-December 2014). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nefro.2020.04.007DOI Listing

Nangibotide in patients with septic shock: a Phase 2a randomized controlled clinical trial.

Intensive Care Med 2020 May 28. Epub 2020 May 28.

Department of Critical Care Medicine, St Luc University Hospital, Université Catholique de Louvain, Brussels, Belgium.

Purpose: Nangibotide is a specific TREM-1 inhibitor that tempered deleterious host-pathogens interactions, restored vascular function, and improved survival, in animal septic shock models. This study evaluated the safety and pharmacokinetics of nangibotide and its effects on clinical and pharmacodynamic parameters in septic shock patients.

Methods: This was a multicenter randomized, double-blind, two-stage study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00134-020-06109-zDOI Listing

Serum Procalcitonin Level Is Associated with Positive Blood Cultures, In-hospital Mortality, and Septic Shock in Emergency Department Sepsis Patients.

Cureus 2020 Apr 24;12(4):e7812. Epub 2020 Apr 24.

Emergency Medicine, Envision Physician Services, Nashville, USA.

This study examines the accuracy of initial and subsequent serum procalcitonin (PCT) levels in predicting positive blood cultures, in-hospital mortality, and development of septic shock in emergency department (ED) patients with severe sepsis. This study includes all patients who presented to our ED with an admission diagnosis of severe sepsis over a period of nine months. The median initial PCT was 0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7759/cureus.7812DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249749PMC

Severe Multiorgan Failure Following Yellow Fever Vaccination.

Vaccines (Basel) 2020 May 26;8(2). Epub 2020 May 26.

Center for Infectious Diseases, Virology, University Hospital of Heidelberg, 69120 Heidelberg, Germany.

Background: The yellow fever (YF) vaccination is recommended by the WHO for people traveling or living in endemic areas at risk for yellow fever infections in Africa and South America. Although the live attenuated yellow fever vaccine is a safe and efficient vaccine, rare serious adverse events after vaccination have been reported.

Case Presentation: We present the case of a 74-year-old male with multiorgan failure after yellow fever vaccination for a trip to Brazil. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/vaccines8020249DOI Listing

OroxylinA reverses lipopolysaccharide-induced adhesion molecule expression and endothelial barrier disruption in the rat aorta.

Toxicol Appl Pharmacol 2020 May 25;400:115070. Epub 2020 May 25.

Department of Medical Research, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan; CardioVascular Research Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan,; Department of Life Sciences, Tzu Chi University, Hualien, Taiwan; Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, IL, USA.

Vascular dysfunction plays a critical role in the pathogenesis of sepsis. We elucidated the mechanisms underlying the amelioration of lipopolysaccharide (LPS)-induced vascular inflammation by oroxylin A (OroA) post-treatment in rats. The animals were intraperitoneally injected with LPS (10 mg/kg) to induce systemic inflammation and intravenously (iv) administered OroA (15 mg/kg) 6 h after the LPS treatment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.taap.2020.115070DOI Listing

Are other effects of Dexmedetomidine playing a role in explaining norepinephrine requirements decrease in septic shock patients?

Minerva Anestesiol 2020 May 28. Epub 2020 May 28.

Anestesia e Rianimazione 1U, Department of Anesthesia, Intensive Care and Emergency, Città della Salute e della Scienza Hospital, Turin, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.23736/S0375-9393.20.14725-4DOI Listing

Sepsis is underreported in Swedish intensive care units: a retrospective observational multicentre study.

Acta Anaesthesiol Scand 2020 May 28. Epub 2020 May 28.

Department of Clinical Medicine, Anaesthesiology and Intensive Care, Lund University, SE-22185, Lund, Sweden.

Background: Sepsis is a common indication for admission to the intensive care unit (ICU). Since definitions vary across studies, comparisons of prevalence and outcomes have been challenging. We aimed to compare sepsis according to ICU discharge codes with sepsis according to Sepsis-3 criteria and to investigate the epidemiology of sepsis in the ICU. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/aas.13647DOI Listing

Roles of angiotensin II as vasopressor in vasodilatory shock.

Future Cardiol 2020 May 28. Epub 2020 May 28.

Department of Critical Care, Guy's & St. Thomas' Hospital, London SE1 7EH, UK.

Shock is an acute condition of circulatory failure resulting in life-threatening organ dysfunction, high morbidity and high mortality. Current management includes fluid and catecholamine therapy to maintain adequate mean arterial pressure and organ perfusion. Norepinephrine is recommended as first-line vasopressor, but other agents are available. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/fca-2020-0019DOI Listing

Ceftolozane/Tazobactam for Treatment of Severe ESBL-Producing Infections: A Multicenter Nationwide Clinical Experience (CEFTABUSE II Study).

Open Forum Infect Dis 2020 May 21;7(5):ofaa139. Epub 2020 Apr 21.

Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.

Background: Few data are reported in the literature about the outcome of patients with severe extended-spectrum β-lactamase-producing (ESBL-E) infections treated with ceftolozane/tazobactam (C/T), in empiric or definitive therapy.

Methods: A multicenter retrospective study was performed in Italy (June 2016-June 2019). Successful clinical outcome was defined as complete resolution of clinical signs/symptoms related to ESBL-E infection and lack of microbiological evidence of infection. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ofid/ofaa139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237821PMC

A case of fulminant sepsis caused by after a dog bite.

IDCases 2020 11;21:e00798. Epub 2020 May 11.

Department of Emergency Medicine, Medical University of Gdansk, Poland.

Many species of microorganisms of various human pathogenicity have been identified in the oral cavities of dogs and cats. One of them is , a Gram-negative bacterium of the family, with unique abilities to forage sugars from host tissues and avoid the host immune response. Although may be isolated from the oral cavities of most dogs and cats, severe human infection is very rare according to studies (0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.idcr.2020.e00798DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240167PMC

Phase I study of bintrafusp alfa, a bifunctional fusion protein targeting TGF-β and PD-L1, in patients with pretreated biliary tract cancer.

J Immunother Cancer 2020 May;8(1)

Department of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital East, Kashiwa, Japan

Background: Patients with biliary tract cancer (BTC) have poor prognosis with few treatment options. Bintrafusp alfa, a first-in-class bifunctional fusion protein composed of the extracellular domain of the transforming growth factor (TGF)-βRII receptor (a TGF-β 'trap') fused to a human IgG1 antibody blocking programmed death ligand 1 (PD-L1), has shown clinical efficacy in multiple solid tumors.

Methods: In this phase I, open-label trial expansion cohort, Asian patients with BTC whose disease progressed after first-line chemotherapy received bintrafusp alfa 1200 mg every 2 weeks until disease progression, unacceptable toxicity, or withdrawal. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/jitc-2020-000564DOI Listing

Septic shock with methicillin-sensitive Staphylococcus aureus secondary to continuous subcutaneous insulin infusion by external pump.

Diabetes Metab 2020 May 24. Epub 2020 May 24.

Diabetology, Endocrinology and Nutrition Department, Paris Saint-Joseph Hospital, 75014 Paris, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.diabet.2020.05.007DOI Listing

A case report of iatrogenic gas gangrene post colonoscopy successfully treated with conservative management- is surgery always necessary?

BMC Gastroenterol 2020 May 27;20(1):163. Epub 2020 May 27.

The Mater Hospital, Townsville, Australia.

Background: Colonoscopy is a routine procedure in diagnosis and treatment of colonic disease. While generally regarded as a safe procedure, potentially fatal complications can occur. Gas gangrene is one such complication, with very high mortality. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12876-020-01314-yDOI Listing

Role of DVET in severe neonatal sepsis in an era of high antibiotic resistance: a retrospective observational study.

J Matern Fetal Neonatal Med 2020 May 27:1-6. Epub 2020 May 27.

Department of Neonatology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India.

Sepsis is a significant cause of mortality and morbidity in the NICU despite the potent armamentarium of antibiotics. Recently, there has been a considerable increase in antimicrobial resistance even to high-end 3rd line antibiotics. Thus, there is a need to look into adjunctive therapies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/14767058.2020.1771303DOI Listing

Novel Role of Endothelial Derived Exosomal HSPA12B in Regulating Macrophage Inflammatory Responses in Polymicrobial Sepsis.

Front Immunol 2020 7;11:825. Epub 2020 May 7.

Department of Surgery, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN, United States.

Endothelial cell dysfunction contributes to sepsis induced initiate immune response and the infiltration of immune cells into organs, resulting in organ injury. Heat shock protein A12B (HSPA12B) is predominantly expressed in endothelial cells. The present study investigated whether endothelial HSPA12B could regulate macrophage pro-inflammatory response during sepsis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fimmu.2020.00825DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221167PMC

Effect of early enteral nutrition on outcomes of trauma patients requiring intensive care.

Chin J Traumatol 2020 Apr 21. Epub 2020 Apr 21.

Department of Emergency and Critical Care, First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China. Electronic address:

Purpose: To investigate the effect of early enteral nutrition on outcomes of trauma patients in the intensive care unit (ICU).

Methods: Clinical data of trauma patients in the ICU of Daping Hospital, China from January 2012 to December 2017 was retrospectively analyzed, including patient age, gender, injury mechanism, injury severity score (ISS), nutritional treatment, postoperative complications (wound infection, abdominal abscess, anastomotic rupture, pneumonia), mortality, and adverse events (nausea, vomiting, abdominal distention). Only adult trauma patients who developed bloodstream infection after surgery for damage control were included. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cjtee.2020.04.006DOI Listing

COVID-19 patients exhibit less pronounced immune suppression compared with bacterial septic shock patients.

Crit Care 2020 May 26;24(1):263. Epub 2020 May 26.

Department of Intensive Care Medicine, Radboud University Medical Center, Internal Mail 710, PO Box 9101, 6500 HB, Nijmegen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13054-020-02896-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250249PMC

The utility of red cell distribution width to predict mortality of septic patients in a tertiary hospital of Nepal.

BMC Emerg Med 2020 May 26;20(1):43. Epub 2020 May 26.

Department of General Practice and Emergency Medicine, Maharajgunj Medical Campus, Institute of Medicine, Tribhuvan University, Kathmandu, Nepal.

Background: Sepsis is a common problem encountered in the emergency room which needs to be intervened early. Predicting prognosis is always a difficult task in busy emergency rooms using present scores, which has several variables to calculate. Red cell distribution width (RDW) is an easy, cheap, and efficacious score to predict the severity and mortality of patients with sepsis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12873-020-00337-8DOI Listing

Ultrasonic Assessment of Optic Nerve Sheath Diameter in Patients at Risk of Sepsis-Associated Brain Dysfunction: A Preliminary Report.

Int J Environ Res Public Health 2020 May 22;17(10). Epub 2020 May 22.

Department of Anaesthesiology and Intensive Care, Faculty of Medical Sciences in Katowice, Medical University of Silesia, 40-752 Katowice, Poland.

Sepsis-associated brain dysfunction (SABD) with increased intracranial pressure (ICP) is a complex pathology that can lead to unfavorable outcome. Ultrasonographic measurement of optic nerve sheath diameter (ONSD) is used for non-invasive assessment of ICP. We aimed to assess the role of ONSD as a SABD screening tool. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijerph17103656DOI Listing

Albumin-to-Fibrinogen Ratio Independently Predicts 28-Day Mortality in Patients with Peritonitis-Induced Sepsis.

Mediators Inflamm 2020 6;2020:7280708. Epub 2020 May 6.

Department of Infectious Disease, Taizhou People's Hospital, Medical School of Nantong University, China.

Background: This study is aimed at investigating whether albumin-to-fibrinogen ratio (AFR) could independently predict the prognosis in patients with peritonitis-induced sepsis.

Methods: A total of 246 eligible patients who were scheduled to undergo surgical treatment for peritonitis-induced sepsis were enrolled in this study. The primary observational endpoint was 28-day hospital mortality. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2020/7280708DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225846PMC

Primary peritonitis in an adolescent boy

Orv Hetil 2020 06;161(23):977-979

Központi Radiológiai Osztály,Markusovszky Egyetemi Oktatókórház Szombathely.

Primary peritonitis is very rare in healthy children without predisposing factors. In the absence of unique factors and signs, the clinical picture does not differ from secondary peritonitis. Therefore, the diagnosis is almost always an intraoperative diagnosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1556/650.2020.31757DOI Listing

Cefepime Versus Cefepime Plus Amikacin as an Initial Antibiotic Choice for Pediatric Cancer Patients With Febrile Neutropenia in an Era of Increasing Cefepime Resistance.

Pediatr Infect Dis J 2020 May 20. Epub 2020 May 20.

Department of Pediatrics.

Background: We investigated the treatment outcomes before and after the addition of amikacin to cefepime monotherapy as an initial empirical antibiotic treatment in pediatric cancer patients with febrile neutropenia.

Methods: This was a retrospective historical cohort study. The subjects were pediatric cancer patients who visited the emergency room at the Samsung Medical Center, Seoul, Korea, due to chemotherapy-induced febrile neutropenia, between January 2011 and December 2016. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/INF.0000000000002751DOI Listing

Comparison of Single-Dose and Extended-Duration Empiric Aminoglycoside Combination Therapy in Patients With Septic Shock.

Am J Ther 2020 Jan 16. Epub 2020 Jan 16.

Background: Empiric combination antimicrobial therapy is often used in patients with decompensating septic shock. However, the optimal duration of combination therapy is unknown.

Study Question: The goal of this study was to compare the clinical effects of a single dose of an aminoglycoside to an extended duration of aminoglycosides for combination therapy in patients with septic shock without renal dysfunction. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MJT.0000000000001136DOI Listing
January 2020

Transverse colon perforation in the mediastinum after esophagectomy: a case report.

Surg Case Rep 2020 May 25;6(1):114. Epub 2020 May 25.

Division of Advanced Surgical Science and Technology, Graduate School of Medicine, University of Tohoku, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8574, Japan.

Background: While anastomotic leakage, recurrent laryngeal nerve paralysis, and pneumonia are well-known complications of esophagectomy, the incidence of hiatal hernia after esophagectomy for carcinoma has been reported to only be between 0.6 and 10%. We report a very rare case of hiatal hernia with transverse colon rupture in the mediastinum after esophagectomy in a 65-year-old woman. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40792-020-00862-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247284PMC

Evaluation of fluid responsiveness during COVID-19 pandemic: what are the remaining choices?

J Anesth 2020 May 25. Epub 2020 May 25.

Department of Anesthesia and Critical Care Medicine, Faculty of Medicine, Cairo University, 01 Elsarayah Street, Elmanyal, Cairo, 11559, Egypt.

Non-protocolized fluid administration in critically ill patients, especially those with acute respiratory distress syndrome (ARDS), is associated with poor outcomes. Therefore, fluid administration in patients with Coronavirus disease (COVID-19) should be properly guided. Choice of an index to guide fluid management during a pandemic with mass patient admissions carries an additional challenge due to the relatively limited resources. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00540-020-02801-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246295PMC

Ultrasensitive digital quantification of cytokines and bacteria predicts septic shock outcomes.

Nat Commun 2020 May 25;11(1):2607. Epub 2020 May 25.

Pritzker School of Molecular Engineering, The University of Chicago, Chicago, IL, 60637, USA.

Quantification of pathogen and host biomarkers is essential for the diagnosis, monitoring, and treatment of infectious diseases. Here, we demonstrate sensitive and rapid quantification of bacterial load and cytokines from human biological samples to generate actionable hypotheses. Our digital assay measures IL-6 and TNF-α proteins, gram-negative (GN) and gram-positive (GP) bacterial DNA, and the antibiotic-resistance gene bla with femtomolar sensitivity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41467-020-16124-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7248118PMC

Use, timing and factors associated with tracheal intubation in septic shock: a prospective multicentric observational study.

Ann Intensive Care 2020 May 24;10(1):62. Epub 2020 May 24.

Medical Intensive Care Unit, Angers University Hospital, Angers, France.

Background: No recommendation exists about the timing and setting for tracheal intubation and mechanical ventilation in septic shock.

Patients And Methods: This prospective multicenter observational study was conducted in 30 ICUs in France and Spain. All consecutive patients presenting with septic shock were eligible. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13613-020-00668-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245631PMC

A quick stone component analysis matters in postoperative fever: a propensity score matching study of 1493 retrograde intrarenal surgery.

World J Urol 2020 May 24. Epub 2020 May 24.

Department of Urology, Minimally Invasive Surgery Center, The First Affiliated Hospital of Guangzhou Medical University, Kangda Road 1, Haizhu District, Guangzhou, 510230, China.

Objective: To evaluate the role of stone components in postoperative fever following RIRS, and to investigate the role of quick stone component analysis during RIRS procedure.

Patients And Methods: 1493 patients with RIRS were retrospectively reviewed. Propensity score matching (PSM) analysis was performed as infection stones (IS) vs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00345-020-03268-yDOI Listing

Septic shock caused by Capnocytophaga canis after a cat scratch.

Eur J Clin Microbiol Infect Dis 2020 May 24. Epub 2020 May 24.

Division of Infectious Diseases, Department of Medicine, Geneva University Hospitals, University of Geneva, Geneva, Switzerland.

Capnocytophaga canis is an uncommon cause of septic shock. Only three cases have been previously reported in the literature. In this article, we describe the case of a 70-year-old male admitted to the intensive care unit for septic shock of unknown origin. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10096-020-03922-8DOI Listing

Spontaneous celiacomesenteric trunk dissection: Case report.

Int J Surg Case Rep 2020 May 21;71:128-131. Epub 2020 May 21.

Department of Radiology, Trauma and BurnCenter of Ben Arous, Tunisia.

Introduction: The celiacomesenteric trunk (CMT) is one of the most striking among the different variations of the normal vascularisation of the gastro-intestinal tract. It is often accidentally discovered during autoptical dissections, angiography or abdominal computed tomography (CT).

Case Presentation: A 27-year-old man was admitted to emergency for an acute abdominal pain. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijscr.2020.04.103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256209PMC