33,312 results match your criteria Septic Shock


Postoperative Complications and Impact of Diabetes Mellitus Severity on Revision Total Knee Arthroplasty.

J Knee Surg 2019 Jan 16. Epub 2019 Jan 16.

Department of Orthopedic Surgery, Hospital for Special Surgery, New York, New York.

Total knee arthroplasty (TKA) is a common and effective treatment of knee osteoarthritis. As the amount of TKAs performed increases, so does the number of TKA failures and subsequent revisions. Diabetes mellitus (DM) has been shown to increase complications following orthopaedic procedures. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/s-0038-1677542DOI Listing
January 2019
1 Read

Evidence-Based Study Design for Hospital-Acquired Bacterial Pneumonia and Ventilator-Associated Bacterial Pneumonia.

J Infect Dis 2019 Jan 11. Epub 2019 Jan 11.

Foundation for the National Institutes of Health, North Bethesda, Maryland.

Background: The US Food and Drug Administration solicited evidence-based recommendations to improve guidance for studies of hospital-acquired bacterial pneumonia (HABP) and ventilator-associated bacterial pneumonia (VABP).

Methods: We analyzed 7 HABP/VABP datasets to explore novel noninferiority study endpoints and designs, focusing on alternatives to all-cause mortality (ACM).

Results: ACM at day 28 differed for ventilated HABP (27. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/infdis/jiy578DOI Listing
January 2019

Temocillin plasma and pancreatic tissue concentrations in a critically ill patient with septic shock.

J Antimicrob Chemother 2019 Jan 14. Epub 2019 Jan 14.

Department of Critical Care Medicine, Cliniques universitaires Saint-Luc, Université catholique de Louvain, Brussels, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/jac/dky565DOI Listing
January 2019

Occult child abuse presenting as pneumatosis intestinalis and portomesenteric venous gas - a case report.

BMC Pediatr 2019 Jan 15;19(1):21. Epub 2019 Jan 15.

Department of Pediatric Emergency Medicine, Children's Hospital, China Medical University, Taichung, Taiwan.

Background: Pneumatosis intestinalis and portomesenteric venous gas are usually caused by necrotizing enterocolitis; however they can occur secondary to abusive abdominal trauma with bone fractures and bruising. It is difficult to recognize initially if there is no bruising on the skin or bone fractures.

Case Presentation: We report a 1-year-old child with no obvious history of trauma who presented with conscious disturbance. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12887-018-1382-6DOI Listing
January 2019

Effect of Levocarnitine vs Placebo as an Adjunctive Treatment for Septic Shock: The Rapid Administration of Carnitine in Sepsis (RACE) Randomized Clinical Trial.

JAMA Netw Open 2018 Dec 7;1(8):e186076. Epub 2018 Dec 7.

Berry Consultants, Austin, Texas.

Importance: Sepsis induces profound metabolic derangements, while exogenous levocarnitine mitigates metabolic dysfunction by enhancing glucose and lactate oxidation and increasing fatty acid shuttling. Previous trials in sepsis suggest beneficial effects of levocarnitine on patient-centered outcomes.

Objectives: To test the hypothesis that levocarnitine reduces cumulative organ failure in patients with septic shock at 48 hours and, if present, to estimate the probability that the most efficacious dose will decrease 28-day mortality in a pivotal phase 3 clinical trial. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/jamanetworkopen.2018.6076DOI Listing
December 2018

Role of Thiamin in Health and Disease.

Nutr Clin Pract 2019 Jan 15. Epub 2019 Jan 15.

Internal Medicine Department, Medical School, São Paulo State University (Unesp), Botucatu, São Paulo, Brazil.

Thiamin is a hydrosoluble vitamin that plays a role in several biological processes, mainly in glucose metabolism. There are several risk factors for developing thiamin deficiency, such as malnutrition, refeeding syndrome, gastrointestinal surgery, and alcoholism. Recently, the role of thiamin in critically ill patients has gained prominence, and the prevalence of thiamin deficiency was found to be increased in patients with severe burns, major surgery, septic shock, end-stage renal disease, and heart failure. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ncp.10234DOI Listing
January 2019

Vasoactive Agent Use in Septic Shock: Beyond First-Line Recommendations.

Pharmacotherapy 2019 Jan 15. Epub 2019 Jan 15.

Department of Pharmacy, Shirley Ryan Ability Lab, Chicago, Illinois, USA.

Septic shock is a life-threatening disorder associated with high mortality rates requiring rapid identification and intervention. Vasoactive agents are often required to maintain goal hemodynamics and preserve tissue perfusion. However, guidance regarding the proper administration of adjunct agents for the management of septic shock is limited in patients who are refractory to norepinephrine. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/phar.2220DOI Listing
January 2019

Effect of Shenfu injection on lipopolysaccharide (LPS)-induced septic shock in rabbits.

J Ethnopharmacol 2019 Jan 11. Epub 2019 Jan 11.

National Key Research Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, PR China; Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Peking University, Beijing 100191, PR China. Electronic address:

Ethnopharmacological Relevance: Shenfu injection is a popular Chinese herbal formula that has been widely used in the treatment of shock in China.

Aim Of The Study: To investigate the effect of Shenfu injection on lipopolysaccharide (LPS)-induced septic shock in rabbits.

Materials And Methods: We established a septic shock model in rabbits by administering an intravenous injection of 0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jep.2019.01.008DOI Listing
January 2019

Comparison of International Pediatric Sepsis Consensus Conference Versus Sepsis-3 Definitions for Children Presenting With Septic Shock to a Tertiary Care Center in India: A Retrospective Study.

Pediatr Crit Care Med 2019 Jan 11. Epub 2019 Jan 11.

All authors: Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.

Objectives: To evaluate the proportion of children fulfilling "Sepsis-3" definition and International Pediatric Sepsis Consensus Conference definition among children diagnosed to have septic shock and compare the mortality risk between the two groups.

Design: Retrospective chart review.

Setting: PICU of a tertiary care teaching hospital from 2014 to 2017. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/PCC.0000000000001864DOI Listing
January 2019

Risk factors for treatment failure in patients receiving betalactam/betalactamase inhibitor combinations for Enterobacteriaceae bloodstream infection: a retrospective single center cohort study.

Int J Antimicrob Agents 2019 Jan 9. Epub 2019 Jan 9.

Infectious Diseases Unit, Department of Medical and Surgical Sciences, Policlinico Sant'Orsola Malpighi, University of Bologna.

Objectives: To investigate the risk factors for treatment failure in patients receiving in vitro active therapy with betalactam/betalactamase inhibitor (BL/BLI) for Enterobacteriaceae bloodstream infection (E-BSI).

Methods: Retrospective single-centre study of patients diagnosed with E-BSI at our centre over 4-year period.

Exclusion Criteria: age <18 years, clinical data not available, polymicrobial BSI, failure to receive in vitro active therapy, death within 72 hours from drawing index blood cultures. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijantimicag.2019.01.005DOI Listing
January 2019

The Modified 5-item Frailty Index (mFI-5) - a concise and useful tool for assessing the impact of frailty on post-operative morbidity following elective posterior lumbar fusions (PLF).

World Neurosurg 2019 Jan 10. Epub 2019 Jan 10.

Department of Orthopaedics, The Ohio State University Wexner Medical Center. Electronic address: https://spine.osu.edu/about/our-team.

Background: The modified 5-item frailty index (mFI-5) is a concise co-morbidity based risk stratification tool that has been shown to predict the occurrence of adverse outcomes following various orthopaedic surgeries.

Methods: The 2012-2016 American College of Surgeons - National Surgical Quality Improvement Program (ACS-NSQIP) dataset was used to identify patients undergoing an elective 1-to-2 level posterior lumbar fusion for degenerative lumbar pathology. The mFI-5 score was calculated on the basis of the presence of the five co-morbidities - congestive heart failure within 30 days prior to surgery, insulin-dependent or non-insulin dependent diabetes mellitus, chronic obstructive pulmonary disease or pneumonia, partially dependent or totally dependent functional health status at time of surgery and hypertension requiring medication. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S18788750193003
Publisher Site
http://dx.doi.org/10.1016/j.wneu.2018.12.168DOI Listing
January 2019
1 Read

[Adams-Oliver syndrome and cutis marmorata telangiectatica congenita].

Ann Dermatol Venereol 2019 Jan 9. Epub 2019 Jan 9.

Service de néonatologie et réanimation néonatale, CHU Hassan II, Fès, Maroc.

Adams-Oliver syndrome (AOS) is a congenital condition characterized by congenital aplasia cutis and transverse limb defects. Herein we report a case of an infant with severe intra-uterine growth restriction presenting AOS associated with cutis marmorata telangiectatica but with no other organ complications. The outcome was complicated by hemorrhagic and septic shock, which resulted in the death of the infant in a setting of multiorgan failure. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.annder.2018.11.009DOI Listing
January 2019

Pre-hospital mechanical ventilation in septic shock patients.

Am J Emerg Med 2019 Jan 7. Epub 2019 Jan 7.

Department of Anesthesia & Intensive Care Unit, SAMU, Hôpital Necker - Enfants Malades, 149 rue de Sèvres, University Paris Descartes, 75015 Paris, France.

Background: Mechanical ventilation can cause deleterious effects on the lung and thus alter patient's prognosis. The aim of this study was to describe the characteristics of prehospital mechanical ventilation in patients with septic shock requiring mechanical ventilation in the prehospital setting.

Methods: Patients with septic shock subjected to pre-hospital intubation and mechanical ventilation by a mobile intensive care unit were consecutively included and retrospectively analysed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ajem.2018.12.047DOI Listing
January 2019

Miliary pattern MRSA sepsis following clandestine intravenous infusion.

Forensic Sci Med Pathol 2019 Jan 12. Epub 2019 Jan 12.

Office of the Medical Examiner, Greenville County, South Carolina, Pathology Associates of Greenville and the Greenville Health System University Medical Center, Greenville, SC, USA.

Intravascular devices aid in drug administration and fluid replacement for hospitalized patients and are thus an integral part of modern medical care; however, poor aseptic technique and improper manipulation of infusion devices increase the risk of infections secondary to catheterization that can progress to sepsis and septic shock. We report the case of a woman who presented with altered mental status after receiving normal saline through an intravenous catheter placed by a medically untrained individual. Less than 24 h following her initial presentation to emergency medical services the patient became unresponsive to multiple vasopressors and broad-spectrum antibiotics and succumbed to septic shock. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12024-018-0077-5DOI Listing
January 2019

Successful Pharmacotherapy for Multiple Acute Decompensation Events in a Cirrhotic Patient with Acute-on-chronic Liver Failure: A Case Report.

J Transl Int Med 2018 Dec 31;6(4):189-193. Epub 2018 Dec 31.

Department of Gastroenterology, General Hospital of Shenyang Military Area, Shenyang 110840, Liaoning Province, China.

Acute-on-chronic liver failure (ACLF) is a potentially lethal syndrome, which is characterized by an acute deterioration of liver function in patients with chronic liver diseases. The present paper reported that an alcoholic cirrhotic patient with ACLF developed septic shock, hydrothorax, ascites, hepatic encephalopathy, acute kidney injury, and acute upper gastrointestinal bleeding at the same hospitalization and was successfully rescued by pharmacotherapy alone without any invasive intervention. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2478/jtim-2018-0035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326027PMC
December 2018

Hydrocortisone, Vitamin C and thiamine for the treatment of sepsis and septic shock following cardiac surgery.

Indian J Anaesth 2018 Dec;62(12):934-939

Department of Cardiac Anesthesia, U.N. Mehta Institute of Cardiology and Research Center, Ahmadabad, Gujarat, India.

Background And Aims: The effect of vitamin C on vasopressor requirement in critically ill patients have been evaluated previously. We aimed to evaluate the effect of vitamin C, hydrocortisone and thiamine on vasopressor requirement and mortality in post-operative adult cardiac surgical patients with septic shock.

Methods: About 24 patients with septic shock were randomised into Group 1 (receiving matching placebo per day for 4 days) and Group 2 (receiving 6 g vitamin C, 400 mg thiamine and 200 mg hydrocortisone per day for 4 days). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/ija.IJA_361_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299773PMC
December 2018

A Nationwide Comparison Between Sepsis-2 and Sepsis-3 Definition in Japan.

J Intensive Care Med 2019 Jan 13:885066618823151. Epub 2019 Jan 13.

1 Department of Emergency Medicine, Asahikawa Medical University, Asahikawa, Japan.

Background:: Currently, it remains controversial whether the Sepsis-3 definition provides the most appropriate criteria for clinical use. The purpose of this study was to compare between the Sepsis-2 and Sepsis-3 definitions using Japan's nationwide registry.

Methods:: Data were obtained from a multicenter registry conducted at 42 intensive care units (ICUs) throughout Japan, in which patients received treatment for severe sepsis or septic shock between January 2011 and December 2013. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0885066618823151DOI Listing
January 2019
1 Read

Septic shock due to Candida famata (Debaryomyces hansenii) candidemia in an ICU immunocompetent trauma-patient.

J Infect Public Health 2019 Jan 8. Epub 2019 Jan 8.

Department of Intensive Care, University Hospital of Thessaly Biopolis, Larissa, Greece.

Sepsis related to Candida famata (C. famata) fungemia is extremely rare in immunocompetent patients. Moreover, septic shock has not been reported due to this yeast. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jiph.2018.12.015DOI Listing
January 2019
3 Reads

A Review of Early Warning Systems for Prompt Detection of Patients at Risk for Clinical Decline.

J Trauma Acute Care Surg 2019 Jan 10. Epub 2019 Jan 10.

Rutgers-Robert Wood Johnson Medical School, New Brunswick, NJ.

Early Warning Scores (EWS) are a composite evaluation of a patient's basic physiology, changes of which are the first indicators of clinical decline and are used to prompt further patient assessment and when indicated intervention. These are sometimes referred to as "track and triggers systems" with tracking meant to denote periodic observation of physiology and trigger being a predetermined response criteria. This review article examines the most widely used EWS, with special attention paid to those used in military and trauma populationsThe earliest EWS is the Modified Early Earning Score (MEWS). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/TA.0000000000002197DOI Listing
January 2019
1 Read

Norepinephrine in septic shock.

Intensive Care Med 2019 Jan 10. Epub 2019 Jan 10.

Departmento de Medicina Intensiva, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00134-018-5499-8DOI Listing
January 2019
1 Read

Comparison of Survival Prediction with Single versus Combination Use of Microcirculation End Point Resuscitation in Sepsis and Septic Shock.

Acta Med Indones 2018 Oct;50(4):275-282

Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National Hospital, Jakarta, Indonesia.

Background: lactate clearance and central venous oxygen saturation (ScvO2) are two methods for determining tissue oxygenation adequacy. There is a controversy regarding method better associates with and predicts sepsis and septic shock patients' mortality. This study address the association of achieving one or two targets of microcirculatory resuscitation endpoints and early mortality in sepsis and septic shock. Read More

View Article

Download full-text PDF

Source
October 2018
1 Read

[Bacteria that eat human lurking in the Ariake Sea- infection].

Rinsho Biseibutshu Jinsoku Shindan Kenkyukai Shi 2018 Dec;28(2):49-57

Shida Hospital.

There are currently 76 species of bacteria in the genus , which is a halophilic gram-negative bacillus, 12 of which are pathogenic in humans. It is usually known as a foodborn infectious bacterium related to gastrointestinal tract. develops muscle tissue necrosis of limb and septic shock in 1 to 3 days when infected in patients with liver injury or immune function deterioration and many die from multiple organ dysfunction. Read More

View Article

Download full-text PDF

Source
December 2018
1 Read

Comparison Between Continuous and Intermittent Administration of Hydrocortisone During Septic Shock: A Randomized Controlled Clinical Trial.

Shock 2019 Jan 7. Epub 2019 Jan 7.

Intensive Care Unit, University Hospital Taher Sfar Mahdia 5100, Tunisia.

Objectives: the best modality of administration of hydrocortisone during septic shock has been poorly evaluated and the guidelines remain unclear in this respect. This study aimed to compare bolus of hydrocortisone to a continuous infusion during septic shock.

Design: randomized controlled, open-label trial. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/SHK.0000000000001316DOI Listing
January 2019
1 Read

Predictors of in-hospital mortality in very eldery patients presenting with acute coronary syndrome: A single-center study.

Turk Kardiyol Dern Ars 2019 Jan;47(1):38-44

Department of Cardiology, Pamukkale University Hospitals, Denizli, Turkey.

Objective: Acute coronary syndrome (ACS) has become more frequent in the elderly population due to increased life expectancy. The aim of this trial was to determine clinical and laboratory factors related to in-hospital mortality in patients over 80 years of age who presented with ACS.

Methods: A total 171 patients (86 men, median age 83 years) who were over 80 years of age and were hospitalized due to a diagnosis of ACS were enrolled in this study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5543/tkda.2018.68792DOI Listing
January 2019
2 Reads

Successful Treatment of Refractory Massive Pulmonary Embolism with Repeated Administration of Systemic Thrombolysis.

Tanaffos 2018 Feb;17(2):127-131

Division of Pulmonary, Critical Care, and Sleep Medicine, Icahn School of Medicine at Mount Sinai, New York, USA.

Background: We report a case series of two patients in the intensive care unit with massive pulmonary embolism and obstructive shock who had resolution of shock after repeated administration of alteplase.

Case Summaries: Both patients were initially dosed 10 mg of alteplase followed by infusion of 90 mg over 2 hours, but remained in obstructive shock requiring significant inotropic and vasopressor support. Both patients were deemed poor candidates for embolectomy. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320563PMC
February 2018
1 Read

Immune parameters and outcomes during Ebola virus disease.

JCI Insight 2019 Jan 10;4(1). Epub 2019 Jan 10.

Unité de Biologie des Infections Virales Emergentes, Institut Pasteur, Centre International de Recherche en Infectiologie, Université Lyon I, INSERM, CNRS, ENS Lyon, Lyon, France.

Background: The West African Ebola virus epidemic from 2014-2016 highlighted the lack of knowledge about the pathogenicity of the virus and the factors responsible for outcome. A performant and rapid diagnosis is of crucial importance, as is overcoming the difficulty of providing high-quality patient management during such an extensive outbreak. Here, we propose to study the role of the immune mediators during Ebola virus disease and to define some molecules of importance in the outcome. Read More

View Article

Download full-text PDF

Source
https://insight.jci.org/articles/view/125106
Publisher Site
http://dx.doi.org/10.1172/jci.insight.125106DOI Listing
January 2019
3 Reads

Microvascular Thrombosis and Ischaemic Limb Losses in Critically Ill Patients.

Hamostaseologie 2019 Jan 9. Epub 2019 Jan 9.

Department of Pathology and Molecular Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada.

Relatively little scientific attention has been given to the small subset of critically ill patients with circulatory shock who develop ischaemic limb losses (symmetrical peripheral gangrene [SPG]). The clinical picture consists of acral (distal extremity) tissue necrosis involving lower limbs in a largely symmetrical fashion and with detectable arterial pulses; in one-third of patients the upper extremities are also affected (potential for four-limb amputations). The laboratory picture includes thrombocytopenia, coagulopathy, and normoblastemia (circulating nucleated red blood cells). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/s-0038-1676823DOI Listing
January 2019
2 Reads

Monitoring haemodynamic response to fluid-challenge in ICU: comparison of pressure recording analytical method and oesophageal Doppler: A prospective observational study.

Eur J Anaesthesiol 2019 Feb;36(2):135-143

From the Department of Anaesthesia, Burn, and Critical Care, Saint-Louis Lariboisière University Hospital (RB, FD, MR, JS, AM, BGC), Department of Anaesthesia and Critical Care, European Hospital Georges-Pompidou, APHP (AN, DD, RP), Paris Diderot University, Sorbonne Paris Cité (AM, BGC), Inserm U942 (AM), Paris Descartes University, Sorbonne Paris Cité (RP), Inserm U1153 (RP) and Inserm U1160, Paris, France (BGC).

Background: The ability of the pressure recording analytical method (PRAM) in tracking change in cardiac output (ΔCO) after a fluid challenge in ICU needs to be evaluated with the most contemporary comparison methods recommended by experts.

Objective: Our objective was to report the trending ability of PRAM in tracking ΔCO after a fluid challenge in ICU and to compare this with oesophageal Doppler monitoring (ODM).

Design: Prospective, observational study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/EJA.0000000000000924DOI Listing
February 2019
1 Read

Vancomycin Dosing, Monitoring and Toxicity: Critical review of the clinical practice.

Clin Exp Pharmacol Physiol 2019 Jan 9. Epub 2019 Jan 9.

Botucatu School of Medicine, University São Paulo State-UNESP, Distrito de Rubiao Junior, without number, Botucatu, Sao Paulo, Brazil.

Vancomycin is an antibiotic used in the treatment of infections caused by multidrug-resistant Gram-positive bacteria, especially methicillin-resistant Staphylococcus aureus. In the last decades, vancomycin has been widely used in hospital environments due to the increasing incidence of sepsis and septic shock. Sepsis may lead to multiple organ failure; it is considered a risk factor for the development of acute kidney injury (AKI), with an overall mortality rate of around 45%, which can reach the surprising rate of 70% with the combination of AKI and sepsis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/1440-1681.13066DOI Listing
January 2019
1 Read

Evaluation of systemic inflammatory response syndrome-negative sepsis from a Chinese regional pediatric network.

BMC Pediatr 2019 Jan 8;19(1):11. Epub 2019 Jan 8.

Departments of Pediatrics and Pediatric Critical Care, Children's Hospital of Fudan University, 399 Wanyuan Road, Shanghai, 201102, China.

Background: The identification of sepsis in children varies depending on the definition used. Our purpose was to compare clinical data and outcome of atypical sepsis, manifested as having sepsis but not fulfilling the criteria of systemic inflammatory response syndrome (SIRS-negative sepsis, SNS), in children based on the modified Angus criteria with those of sepsis (S) and severe sepsis (SS) based on the international consensus criteria.

Methods: Pediatric departments in 11 regional city and county referral hospitals with emergency and intensive care settings in Huai'an serving for 843,000 children participated in a parallel multicenter prospective survey. Read More

View Article

Download full-text PDF

Source
https://bmcpediatr.biomedcentral.com/articles/10.1186/s12887
Publisher Site
http://dx.doi.org/10.1186/s12887-018-1364-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325779PMC
January 2019
4 Reads

[Sepsis Update: Evidence-Based Therapy].

Anasthesiol Intensivmed Notfallmed Schmerzther 2019 Jan 8;54(1):50-62. Epub 2019 Jan 8.

Like polytrauma, acute myocardial infarction or stroke, sepsis and septic shock are medical emergencies that require adequate early detection and immediate, targeted management. The therapy of sepsis and septic shock has developed continuously in recent years. This article provides an overview of the current evidence of sepsis and septic shock therapy and its implementation into clinical practice. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-0625-5521DOI Listing
January 2019
4 Reads

[Diagnostic Approaches in Sepsis - Part 2: Pathogen Detection].

Anasthesiol Intensivmed Notfallmed Schmerzther 2019 Jan 8;54(1):38-48. Epub 2019 Jan 8.

Despite the dissemination of innovative, molecular biology-based and commercially available devices for pathogen detection, culture-based methods with susceptibility testing remain the key principles for guiding antimicrobial treatment of patients suffering from sepsis or septic shock on the ICU. Culture-based methods are able to facilitate pathogen detection from a diversity of specimen (respiratory secretion, intraoperatively obtained smears, aspirates, and so forth). However, the latency from obtainment of the specimen up to pathogen detection with susceptibility testing is a major disadvantage of culture-based methods in critical illness. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-0756-4651DOI Listing
January 2019

[Diagnostic Approaches in Sepsis - Part 1: General Diagnostic Principles, Focus Identification and Source Control].

Anasthesiol Intensivmed Notfallmed Schmerzther 2019 Jan 8;54(1):22-36. Epub 2019 Jan 8.

Sepsis and septic shock represent medical emergencies with persistently high mortality rates. According to the lately revised Surviving Sepsis Campaign (SSC) guidelines, focus identification/pathogen detection and the initial administration of broad-spectrum antibiotics are to be secluded within one hour after recognition of the symptoms of sepsis. However, there is dispute concerning the so called hour-1 bundle. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-0625-5507DOI Listing
January 2019
4 Reads

[Sepsis with intravascular hemolysis caused by Clostridium perfringens].

Lakartidningen 2019 Jan 7;116. Epub 2019 Jan 7.

Region Halland - Infektionskliniken Halmstad, Sweden Region Halland - Infektionskliniken Halmstad, Sweden.

Clostridium perfringens is a gram-positive anaerobic rod commonly found in our natural environment as well as in human intestinal and vaginal microflora. Due to its production of several toxins it may cause numerous infections of varying degrees of severity. Bacteremia, albeit uncommon, is potentially lethal owing to the disruption of red blood cells leading to hemolysis and septic shock in which mortality is very high. Read More

View Article

Download full-text PDF

Source
January 2019

Hepatic portal venous gas related to appendicitis.

J Surg Case Rep 2018 Dec 26;2018(12):rjy333. Epub 2018 Dec 26.

Department of Surgery, National Defense Medical College, 3-2 Namiki, Tokorozawa, Japan.

Background: Hepatic portal venous gas (HPVG) is rare with high mortality. There are few reports on HPVG's association with appendicitis. Here we report a case of HPVG associated with appendicitis. Read More

View Article

Download full-text PDF

Source
https://academic.oup.com/jscr/article/doi/10.1093/jscr/rjy33
Publisher Site
http://dx.doi.org/10.1093/jscr/rjy333DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305834PMC
December 2018
6 Reads

Regulation of soluble CD127 protein release and corresponding transcripts expression in T lymphocytes from septic shock patients.

Intensive Care Med Exp 2019 Jan 8;7(1). Epub 2019 Jan 8.

EA 7426 « Pathophysiology of injury-induced immunosuppression (PI3) » Lyon 1 University / Hospices Civils de Lyon / bioMérieux, 5 place d'Arsonval, 69437, Lyon Cedex 03, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40635-018-0220-3DOI Listing
January 2019

Preoperative Estimated Glomerular Filtration Rate Is a Marker for Postoperative Complications Following Revision Total Knee Arthroplasty.

J Arthroplasty 2018 Dec 8. Epub 2018 Dec 8.

Department of Orthopedics, Complex Joint Reconstruction Center, Hospital for Special Surgery, New York, NY.

Background: Revision total knee arthroplasty (TKA) is an increasingly common procedure, but complication rates are higher than for primary TKA. A requirement for dialysis has been shown to predict postoperative complications in this patient population, but the impact of less severe, but clinically significant, renal impairment has not been addressed.

Methods: A retrospective cohort study was conducted using the American College of Surgeons National Quality Improvement Program Database. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S08835403183118
Publisher Site
http://dx.doi.org/10.1016/j.arth.2018.12.005DOI Listing
December 2018
1 Read

Fournier's Gangrene With Septic Shock and Multiple Organ Dysfunction Syndrome.

Int J Low Extrem Wounds 2019 Jan 8:1534734618818685. Epub 2019 Jan 8.

1 Ruijin Hospital, Shanghai Jiaotong University, Shanghai, People's Republic of China.

Fournier's gangrene is a rare, rapidly progressing, and life-threatening infection associated with necrotizing fasciitis in the perineal, genital, and/or lower abdominal regions. Septic shock and multiple organ dysfunction syndrome due to the condition are even rarer events. We describe the case of a 58-year-old man who visited the emergency department with severely painful swelling in the scrotal, perianal, and lower abdominal regions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1534734618818685DOI Listing
January 2019

First successful hemoadsorption using CytoSorb® in a septic pediatric patient in Kazakhstan: A case report.

Int J Artif Organs 2019 Jan 7:391398818819953. Epub 2019 Jan 7.

1 National Research Center for Maternal and Child Health, Astana, Kazakhstan.

Purpose:: For the first time in Kazakhstan, we have used a combined extracorporeal support, by including the CytoSorb system in a continuous veno-venous hemofiltration system in an 8-month-old patient with a body weight of 5600 g.

Results:: The CytoSorb therapy session resulted in a reduction of inflammation markers IL-6, S100, procalcitonin, and C-reactive protein. Simultaneously, the level of transaminases, creatine kinase, and troponin were normalized, by the end of the session patient hemodynamics were stable and there was no need for vasopressors, acid-base balance was maintained, and the patient was weaned from mechanical ventilation to spontaneous breathing. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0391398818819953DOI Listing
January 2019
2 Reads

Quick Sepsis-related Organ Failure Assessment Versus Systemic Inflammatory Response Syndrome Criteria for Predicting Organ Dysfunction and Mortality.

Cureus 2018 Oct 29;10(10):e3511. Epub 2018 Oct 29.

Emergency Medicine, University of Central Florida College of Medicine, Orlando, USA.

The International Consensus Definition for Sepsis and Septic Shock Task Force has recently developed new methods to determine whether a patient is at risk for end organ failure after he has been suspected to have sepsis. One of the newest measures developed is a quick Sequential (Sepsis-related) Organ Failure Assessment (qSOFA), and it is used to identify patients who are at risk of sepsis outside the intensive care unit. The systemic inflammatory response syndrome (SIRS) score has previously been the standard for determining a patient's sepsis risk and prognosis for future mortality. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7759/cureus.3511DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314391PMC
October 2018
2 Reads

Chemically synthesized Secoisolariciresinol diglucoside (LGM2605) improves mitochondrial function in cardiac myocytes and alleviates septic cardiomyopathy.

J Mol Cell Cardiol 2019 Jan 3;127:232-245. Epub 2019 Jan 3.

Center for Translational Medicine and Department of Pharmacology, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA. Electronic address:

Sepsis is the overwhelming systemic immune response to infection, which can result in multiple organ dysfunction and septic shock. Myocardial dysfunction during sepsis is associated with advanced disease and significantly increased in-hospital mortality. Our group has shown that energetic failure and excess reactive oxygen species (ROS) generation constitute major components of myocardial dysfunction in sepsis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.yjmcc.2018.12.016DOI Listing
January 2019

Suppression of plasminogen activator inhibitor-1 (PAI-1) activity by crocin ameliorates lipopolysaccharide-induced thrombosis in rats.

Food Chem Toxicol 2019 Jan 2;125:190-197. Epub 2019 Jan 2.

School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Greece.

The imbalance between clot formation and fibrinolysis is mainly attributed to increased levels of plasminogen activator inhibitor type 1 (PAI-1), an inhibitor of fibrinolysis closely involved in inflammatory responses such as septic shock. This increase is mediated by many factors, including reactive oxygen species (ROS). The present study was designed to evaluate the prophylactic effect of crocin, a potent natural antioxidant, on PAI-1 in the rat model of endotoxic shock. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.fct.2019.01.001DOI Listing
January 2019
1 Read

Nutrient pattern analysis in critically ill patients using Omics technology (NAChO) - Study protocol for a prospective observational study.

Medicine (Baltimore) 2019 Jan;98(1):e13937

Department of Intensive Care Medicine, Inselspital, Bern University Hospital, University of Bern, Switzerland.

Introduction: Intensive care unit-acquired weakness (ICU-AW) is often observed in critically ill patients with prolonged intensive care unit (ICU) stay. We hypothesized that evolving metabolic abnormalities during prolonged ICU stay are reflected by changing nutrient patterns in blood, urine and skeletal muscle, and that these patterns differ in patients with/without ICU-AW and between patients with/without sepsis.

Methods: In a prospective single-center observational trial, we aim to recruit 100 critically ill patients (ICU length of stay ≥ 5 days) with severe sepsis/septic shock ("sepsis group", n = 50) or severe head trauma/intracerebral hemorrhage ("CNS group", n = 50). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000013937DOI Listing
January 2019
2 Reads

Management of persistent pulmonary hypertension in newborns with ECMO support: a single center's experience.

World J Pediatr 2019 Jan 3. Epub 2019 Jan 3.

Heart Institute, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, 310000, China.

Background: To summarize the experience of management of persistent pulmonary hypertension of the newborn (PPHN) with extracorporeal membrane oxygenation (ECMO) support.

Methods: We presented three neonates with PPHN supported by ECMO in our center. Medical records and patient management notes were retrospectively reviewed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12519-018-0215-xDOI Listing
January 2019
2 Reads

Aberrant splenic artery rising from the superior mesenteric artery: a rare but important anatomical variation.

Surg Radiol Anat 2019 Jan 3. Epub 2019 Jan 3.

General, Digestive, and Endocrine Surgery, Nouvel Hôpital Civil, Université de Strasbourg, 1 Place de L'hôpital, 67100, Strasbourg, France.

Aberrant splenic artery originating from the superior mesenteric artery (SMA) is extremely rare and recognition of this anomaly is important in the pre-operative planning of complex surgery such as pancreatic surgery, liver transplantation and vascular surgery. We present the case of an 80-year-old female diagnosed as septic shock due to mesenteric ischemia and obstructive pyelonephritis. Her splenic artery was originating from the SMA and the anomaly was readily appreciated on the pre-operative CT images. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00276-018-02177-5DOI Listing
January 2019
3 Reads

Evaluation of Antibiotic Use Among Sepsis Patients in an Intensive Care Unit: A cross-sectional study at a referral hospital in Indonesia.

Sultan Qaboos Univ Med J 2018 Aug 19;18(3):e367-e373. Epub 2018 Dec 19.

Department of Pharmaceutical Installation, Dharmais Cancer Hospital, Jakarta, Indonesia.

Objectives: This study aimed to evaluate the appropriateness of antibiotic use and factors associated with outcomes among sepsis patients in an intensive care unit (ICU).

Methods: This cross-sectional study was carried out from February to May 2017 and included all adult patients with sepsis or septic shock admitted to the ICU of Dharmais Cancer Hospital, Jakarta, Indonesia. Data were collected from the patients' medical records. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18295/squmj.2018.18.03.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307646PMC
August 2018
1 Read

Pre-optimisation of patients undergoing emergency laparotomy: a review of best practice.

Anaesthesia 2019 Jan;74 Suppl 1:100-107

Anaesthetic Department, James Cook University Hospital, Middlesbrough, UK.

Although the concept of pre-operative optimisation is traditionally applied to elective surgery, there is ample opportunity to apply similar principles to patients undergoing emergency laparotomy. The key challenge is achieving meaningful improvements in a patient's condition without introducing delays to time-sensitive surgery, which may be required in a matter of hours. Optimisation can be considered in two parts: that of the patient's condition; and that of the care pathway. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/anae.14514DOI Listing
January 2019
2 Reads

[Severe and rare adverse reaction to hydrochlorothiazide].

Rev Alerg Mex 2018 Oct-Dec;65(4):442-445

Hospital Universitario Infanta Sofía, Departamento de Alergia, Madrid, España.

Background: The immune mechanism involved in the reaction to hydrochlorothiazide, which is widely used to control hypertension, is unknown. The short latency period between the take of the drug and the onset of symptoms suggests immediate hypersensitivity.

Case Report: 63-year-old woman with arterial hypertension who, on three occasions, experienced nausea, vomiting, general malaise, shivering, arthralgias, dysthermic sensation, back pain of mechanical characteristics and mild non-productive cough, as well as fever and chest tightness with increased dyspnea and desaturation of up to 88 %, after taking hydrochlorothiazide. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.29262/ram.v65i4.363DOI Listing
January 2019
4 Reads

Methane-Rich Saline Protects Against Sepsis-Induced Liver Damage by Regulating The PPAR-γ/NF-κB Signaling Pathway.

Shock 2018 Dec 21. Epub 2018 Dec 21.

Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an Shaanxi 710061, People's Republic of China.

Sepsis, a life-threatening organ dysfunction due to a dysregulated response to infection, is a common complication of major surgery. Previous studies have showed that methane possesses protective properties. This study aims to investigate the protective effect of methane-rich saline (MRS) on sepsis-induced liver injury. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/SHK.0000000000001310DOI Listing
December 2018
3 Reads

Function is Dissociated From Activation-Related Immunophenotype on Phagocytes From Patients With Sirs/Sepsis Syndrome.

Shock 2018 Dec 26. Epub 2018 Dec 26.

Unidad de Investigación Médica en Inmunoquímica. Centro Médico Nacional "Siglo XXI". Instituto Mexicano del Seguro Social. Cuauhtémoc Av. 330. Zip code 06720. Mexico City. Mexico.

Sepsis is a life-threatening condition associated with failure of at least one organ in the presence of infection. Along with SIRS, the acute systemic inflammatory syndrome without documented infection, sepsis represents a main health problem in intensive care units around the world. Hypercytokinemia and overexpression of activation-markers on leukocytes are frequently reported in SIRS/sepsis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/SHK.0000000000001314DOI Listing
December 2018
2 Reads