729 results match your criteria Septic Arthritis Pediatrics


Invasive Salmonella infections among children in Bintulu, Sarawak, Malaysian Borneo: a 6-year retrospective review.

BMC Infect Dis 2019 Apr 18;19(1):330. Epub 2019 Apr 18.

Institute of Health and Community Medicine, Universiti Malaysia Sarawak, Kota Samarahan, Sarawak, Malaysia.

Background: Invasive Salmonella infections result in significant morbidity and mortality in developing countries. In Asia, typhoid and paratyphoid fever are reported to be the major invasive Salmonella infections, while invasive non-typhoidal Salmonella (iNTS) infections are believed to be uncommon. Data from Sarawak, in Malaysian Borneo, are limited. Read More

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https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
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http://dx.doi.org/10.1186/s12879-019-3963-xDOI Listing
April 2019
1 Read

Clinical features and characteristics of uveitis associated with juvenile idiopathic arthritis in Japan: first report of the pediatric rheumatology association of Japan (PRAJ).

Pediatr Rheumatol Online J 2019 Apr 11;17(1):15. Epub 2019 Apr 11.

Department of Lifetime Clinical Immunology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.

Background: Although there are many reports on Juvenile Idiopathic arthritis-associated uveitis (JIA-U) from various countries, especially from Europe and North America, there are few reports from Asia. Our aim was to investigate the epidemiology, characteristics and predictors of JIA-U in Japan.

Methods: Data were retrospectively collected on 726 patients with JIA from medical records as of April 2016 at 15 medical centers specialized in pediatric rheumatic diseases. Read More

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http://dx.doi.org/10.1186/s12969-019-0318-5DOI Listing
April 2019
1 Read

Clinical and Immunological Phenotype of Patients With Primary Immunodeficiency Due to Damaging Mutations in .

Front Immunol 2019 19;10:297. Epub 2019 Mar 19.

Faculty of Medicine, Center for Chronic Immunodeficiency (CCI), Medical Center, University of Freiburg, Freiburg, Germany.

Non-canonical NF-κB-pathway signaling is integral in immunoregulation. Heterozygous mutations in have recently been established as a molecular cause of common variable immunodeficiency (CVID) and DAVID-syndrome, a rare condition combining deficiency of anterior pituitary hormone with CVID. Here, we investigate 15 previously unreported patients with primary immunodeficiency (PID) from eleven unrelated families with heterozygous -mutations including eight patients with the common p. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00297DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435015PMC
March 2019
12 Reads

X-linked agammaglobulinemia (XLA):Phenotype, diagnosis, and therapeutic challenges around the world.

World Allergy Organ J 2019 22;12(3):100018. Epub 2019 Mar 22.

Division of Allergy Immunology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.

Background: X-linked agammaglobulinemia is an inherited immunodeficiency recognized since 1952. In spite of seven decades of experience, there is still a limited understanding of regional differences in presentation and complications. This study was designed by the Primary Immunodeficiencies Committee of the World Allergy Organization to better understand regional needs, challenges and unique patient features. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S19394551193010
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http://dx.doi.org/10.1016/j.waojou.2019.100018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439403PMC
March 2019
3 Reads

Immunopathogenic Mechanisms and Novel Immune-Modulated Therapies in Rheumatoid Arthritis.

Int J Mol Sci 2019 Mar 16;20(6). Epub 2019 Mar 16.

Department of Microbiology and Immunology, National Defense Medical Center, No. 161, Section 6, MinChuan East Road, Neihu, Taipei City 114, Taiwan.

Rheumatoid arthritis (RA) is a chronic, inflammatory autoimmune disease of unknown etiology. It is characterized by the presence of rheumatoid factor and anticitrullinated peptide antibodies. The orchestra of the inflammatory process among various immune cells, cytokines, chemokines, proteases, matrix metalloproteinases (MMPs), and reactive oxidative stress play critical immunopathologic roles in the inflammatory cascade of the joint environment, leading to clinical impairment and RA. Read More

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http://dx.doi.org/10.3390/ijms20061332DOI Listing
March 2019
1 Read

Clostridium septicum arthritis in a young infant: A case report.

Anaerobe 2019 Mar 11;57:32-34. Epub 2019 Mar 11.

Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Septic arthritis is one of the most serious conditions leading to grave consequences in all age groups, with a number of cases seen in infancy and childhood. Although septic arthritis in neonates is a known clinical entity, it is a diagnostic dilemma for the paediatricians. Of the reported causes of bacterial arthritis, anaerobic bacteria account for only 1%. Read More

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http://dx.doi.org/10.1016/j.anaerobe.2019.03.009DOI Listing
March 2019
3 Reads

Galectin-9 and CXCL10 as biomarkers for disease activity in juvenile dermatomyositis: a longitudinal cohort study and multi-cohort validation.

Arthritis Rheumatol 2019 Mar 12. Epub 2019 Mar 12.

Laboratory of translational immunology, University Medical Centre Utrecht, Utrecht, The Netherlands.

Objective: Objective evaluation of disease activity is challenging in patients with juvenile dermatomyositis (JDM) due to lack of biomarkers, but crucial to avoid both under- and overtreatment. Recently, we identified two proteins that highly correlate with JDM disease activity: galectin-9 and CXCL10. Here, we validate galectin-9 and CXCL10 as biomarkers for disease activity, assess disease-specificity and investigate their potency to predict flares. Read More

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http://dx.doi.org/10.1002/art.40881DOI Listing
March 2019
2 Reads

Calm in the midst of cytokine storm: a collaborative approach to the diagnosis and treatment of hemophagocytic lymphohistiocytosis and macrophage activation syndrome.

Pediatr Rheumatol Online J 2019 Feb 14;17(1). Epub 2019 Feb 14.

Division of Immunolgy, Boston Children's Hospital, Boston, MA, USA.

Background: Hemophagocytic lymphohistiocytosis (HLH) and macrophage activation syndrome (MAS) were historically thought to be distinct entities, often managed in isolation. In fact, these conditions are closely related. A collaborative approach, which incorporates expertise from subspecialties that previously treated HLH/MAS independently, is needed. Read More

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https://ped-rheum.biomedcentral.com/articles/10.1186/s12969-
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http://dx.doi.org/10.1186/s12969-019-0309-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376762PMC
February 2019
7 Reads

Pyogenic sacroiliitis in children: don't forget the very young.

Eur J Pediatr 2019 Apr 7;178(4):575-579. Epub 2019 Feb 7.

Department of Pediatrics, Mount Scopus Hadassah-Hebrew University Medical Center, 91120, Jerusalem, Israel.

Pyogenic sacroiliitis (PS) is rare with less than 100 pediatric cases reported in the medical literature. To better characterize PS in the pediatric population, we investigated a series of children presenting with PS. Retrospective data analysis was done at an academic tertiary center between the years of 2000 and 2017. Read More

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http://dx.doi.org/10.1007/s00431-019-03333-8DOI Listing
April 2019
2 Reads

Dengue and Zika Virus Cross-Reactive Human Monoclonal Antibodies Protect against Spondweni Virus Infection and Pathogenesis in Mice.

Cell Rep 2019 Feb;26(6):1585-1597.e4

Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA; Department of Pathology & Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA; Department of Molecular Microbiology, Washington University School of Medicine, Saint Louis, MO 63110, USA; The Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, Saint Louis, MO 63110, USA. Electronic address:

Spondweni virus (SPOV) is the flavivirus that is most closely related to Zika virus (ZIKV). Although SPOV causes sporadic human infections in Africa, recently it was found in Culex mosquitoes in Haiti. To investigate the pathogenic spectrum of SPOV, we developed infection models in mice. Read More

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http://dx.doi.org/10.1016/j.celrep.2019.01.052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420780PMC
February 2019
9 Reads

The effects of TNF-alpha inhibitor therapy on the incidence of infection in JIA children: a meta-analysis.

Pediatr Rheumatol Online J 2019 Jan 18;17(1). Epub 2019 Jan 18.

Department of Paediatrics, Medical School, University of Pécs, 7. József Attila street, Pécs, 7623, Hungary.

Background: Juvenile Idiopathic arthritis (JIA) is the most common chronic rheumatic disease in childhood. The diagnosis is based on the underlying symptoms of arthritis with an exclusion of other diseases Biologic agents are increasingly used on the side of disease-modifying anti-rheumatic drugs (DMARD) in JIA treatment.

Main Body: The aim of this meta-analysis was to investigate the observed infections in JIA children during tumor necrosis factor (TNF)-alpha inhibitor therapy. Read More

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http://dx.doi.org/10.1186/s12969-019-0305-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339290PMC
January 2019
7 Reads

Answer to November 2018 Photo Quiz.

J Clin Microbiol 2018 Nov 25;56(11). Epub 2018 Oct 25.

Department of Pediatrics, Centre Hospitalier Universitaire Sainte-Justine, Université de Montréal, Montréal, Québec, Canada

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http://dx.doi.org/10.1128/JCM.01294-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204679PMC
November 2018
2 Reads

Photo Quiz: A 5-Year-Old Boy with an Unusual Arthritis of the Right Knee.

J Clin Microbiol 2018 Nov 25;56(11). Epub 2018 Oct 25.

Department of Pediatrics, Centre Hospitalier Universitaire Sainte-Justine, Université de Montréal, Montréal, Québec, Canada

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http://dx.doi.org/10.1128/JCM.01262-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204687PMC
November 2018
2 Reads

The phytosphingosine-CD300b interaction promotes zymosan-induced, nitric oxide-dependent neutrophil recruitment.

Sci Signal 2019 Jan 15;12(564). Epub 2019 Jan 15.

Division of Cellular Therapy/Division of Stem Cell Signaling, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.

Zymosan is a glucan that is a component of the yeast cell wall. Here, we determined the mechanisms underlying the zymosan-induced accumulation of neutrophils in mice. Loss of the receptor CD300b reduced the number of neutrophils recruited to dorsal air pouches in response to zymosan, but not in response to lipopolysaccharide (LPS), a bacterial membrane component recognized by Toll-like receptor 4 (TLR4). Read More

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http://stke.sciencemag.org/lookup/doi/10.1126/scisignal.aar5
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http://dx.doi.org/10.1126/scisignal.aar5514DOI Listing
January 2019
10 Reads

Prepatellar septic bursitis in an 8-year-old boy.

BMJ Case Rep 2019 Jan 14;12(1). Epub 2019 Jan 14.

Department of Pediatrics, Asahi General Hospital, Asahi, Chiba, Japan.

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http://dx.doi.org/10.1136/bcr-2018-228564DOI Listing
January 2019
5 Reads

Systemic levels of anti-PAD4 autoantibodies correlate with airway obstruction in cystic fibrosis.

J Cyst Fibros 2019 Jan 10. Epub 2019 Jan 10.

Department of Infectious Diseases, College of Veterinary Medicine, The University of Georgia, Athens, GA, USA. Electronic address:

Cystic fibrosis (CF) airway disease is characterized by the long-term presence of neutrophil granulocytes. Formation of neutrophil extracellular traps (NETs) and/or autoantibodies directed against extracellular components of NETs are possible contributors to neutrophil-mediated lung damage in CF. The goal of this study was to measure their levels in CF adults compared to healthy controls and subjects with rheumatologic diseases known to develop NET-related autoantibodies and pathologies, rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15691993183097
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http://dx.doi.org/10.1016/j.jcf.2018.12.010DOI Listing
January 2019
9 Reads

Is primary meningococcal arthritis in children more frequent than we expect? Two pediatric case reports revealed by molecular test.

BMC Infect Dis 2018 Dec 27;18(1):703. Epub 2018 Dec 27.

Immunology Division, Section of Pediatrics, Department of Health Sciences, University of Florence and Meyer Children's University Hospital, Florence, Italy.

Background: Primary meningococcal arthritis is a rare infectious disease that occurs in less than 3% of meningococcal infections and is characterized by arthritis without meningitis, fever, rash, or hemodynamic instability Barahona [Case Rep Orthop 4696014:2017 ]. There are no validated clinical criteria that can be used for the diagnosis. We present two pediatric cases of atypical presentation of meningococcal disease revealed by molecular tests. Read More

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https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
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http://dx.doi.org/10.1186/s12879-018-3602-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307139PMC
December 2018
15 Reads

Epidemiological profile of non-infectious uveitis from the rheumatologist's perspective: a survey from two tertiary referral centres in Italy.

Clin Exp Rheumatol 2018 Nov-Dec;36(6 Suppl 115):68-73. Epub 2018 Dec 12.

Research Centre of Systemic Autoinflammatory Diseases and Behçet's Disease and Rheumatology-Ophthalmology Collaborative Uveitis Centre, Department of Medical Sciences, Surgery and Neurosciences, University of Siena, Italy.

Objectives: To describe the epidemiology of non-infectious uveitis (NIU) in two tertiary referral rheumatology units in Central and Southern Italy.

Methods: Two hundred and seventy-eight consecutive NIU patients (417 eyes) evaluated between January 2016 and January 2017 were enrolled. Collected data were analysed in accordance with the primary anatomic site of inflammation, clinical course, and laterality. Read More

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March 2019
10 Reads

Participation in a single-blinded pediatric therapeutic strategy study for juvenile idiopathic arthritis: are parents and patient-participants in equipoise?

BMC Med Ethics 2018 12 20;19(1):96. Epub 2018 Dec 20.

Department of Medical Ethics and Health Law, Leiden University Medical Center, Leiden, the Netherlands.

Background: Genuine uncertainty on superiority of one intervention over the other is called equipoise. Physician-investigators in randomized controlled trials (RCT) need equipoise at least in studies with more than minimal risks. Ideally, this equipoise is also present in patient-participants. Read More

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http://dx.doi.org/10.1186/s12910-018-0336-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302476PMC
December 2018
5 Reads

Acute severe monarthritis: a rare manifestation of scrub typhus.

BMJ Case Rep 2018 Dec 3;11(1). Epub 2018 Dec 3.

Paediatrics, Kasturba Medical College, Manipal, Karnataka, India.

Scrub typhus caused by is an important cause for fever of unknown origin in endemic areas including India. The vasculitis associated with the disease leads to a variety of clinical manifestations. However, the joint involvement is quite rare and not reported in children. Read More

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http://dx.doi.org/10.1136/bcr-2018-227002DOI Listing
December 2018
6 Reads

Infectious and Noninfectious Acute Pericarditis in Children: An 11-Year Experience.

Int J Pediatr 2018 8;2018:5450697. Epub 2018 Nov 8.

Division of Infectious Diseases, Children's Hospital of Michigan, Detroit, MI, USA.

Objective: The study was undertaken to determine the etiology, review management, and outcome in children diagnosed with acute pericarditis during 11 years at tertiary pediatric institution.

Methods: Retrospective chart review of children diagnosed between 2004 and 2014. Patients with postsurgical pericardial effusions were excluded. Read More

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https://www.hindawi.com/journals/ijpedi/2018/5450697/
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http://dx.doi.org/10.1155/2018/5450697DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250032PMC
November 2018
23 Reads

Timing of infliximab and adalimumab initiation despite methotrexate in children with chronic non-infectious anterior uveitis.

Eye (Lond) 2019 Apr 28;33(4):629-639. Epub 2018 Nov 28.

Division of Rheumatology, Cincinnati Children's Hospital Medical Center and Department of Pediatrics, University of Cincinnati, Cincinnati, OH, USA.

Aims: Methotrexate (MTX) is standard treatment in pediatric chronic anterior uveitis (CAU). Addition of tumor necrosis factor-α inhibitors (TNFi) is often needed. We describe the timing and risk factors for TNFi use in children with CAU on MTX. Read More

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http://dx.doi.org/10.1038/s41433-018-0283-0DOI Listing
April 2019
2 Reads

Risks associated with use of TNF inhibitors in children with rheumatic diseases.

Expert Rev Clin Immunol 2018 Nov 19:1-10. Epub 2018 Nov 19.

e Department of Neurosciences, Psychology, Drug Research and Child Health, Rheumatology Unit, Meyer Children's Hospital , University of Florence , Florence , Italy.

Introduction: Tumor necrosis factor alpha (TNF-α) is a pro-inflammatory cytokine involved in the pathogenesis of many inflammatory diseases. Several drugs blocking TNF-α are employed in clinical practice in pediatrics. Given their action on the immune system, TNF-α inhibitors have raised concerns on their safety profile since their introduction. Read More

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http://dx.doi.org/10.1080/1744666X.2019.1550359DOI Listing
November 2018
17 Reads

Adalimumab versus adalimumab and methotrexate for the treatment of juvenile idiopathic arthritis: long-term data from the German BIKER registry.

Scand J Rheumatol 2019 Mar 9;48(2):95-104. Epub 2018 Nov 9.

a Department of Paediatrics , Centre for Paediatric Rheumatology, Asklepios Clinic Sankt Augustin , Sankt Augustin , Germany.

Objective: Adalimumab (ADA) has become a valuable treatment option for juvenile idiopathic arthritis (JIA). The importance of combination with methotrexate (MTX) is unclear.

Method: Data from the German Biologics in Paediatric Rheumatology (BIKER) registry are reported. Read More

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https://www.tandfonline.com/doi/full/10.1080/03009742.2018.1
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http://dx.doi.org/10.1080/03009742.2018.1488182DOI Listing
March 2019
14 Reads

ACR Appropriateness Criteria Acutely Limping Child Up To Age 5.

J Am Coll Radiol 2018 Nov;15(11S):S252-S262

Specialty Chair, Riley Hospital for Children Indiana University, Indianapolis, Indiana.

Imaging plays in important role in the evaluation of the acutely limping child. The decision-making process about initial imaging must consider the level of suspicion for infection and whether symptoms can be localized. The appropriateness of specific imaging examinations in the acutely limping child to age 5 years is discussed with attention in each clinical scenario to the role of radiography, ultrasound, nuclear medicine, computed tomography, and magnetic resonance imaging. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15461440183117
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http://dx.doi.org/10.1016/j.jacr.2018.09.030DOI Listing
November 2018
20 Reads

Generation of functional murine CD11c age-associated B cells in the absence of B cell T-bet expression.

Eur J Immunol 2019 Jan 5;49(1):170-178. Epub 2018 Nov 5.

Center for Immunity and Immunotherapy, Seattle Children's Research Institute, Seattle, WA, USA.

Age-associated B cells (ABC), a novel subset of activated B cells defined by CD11b and CD11c expression, have been linked with both protective anti-viral responses and the pathogenesis of systemic autoimmunity. Expression of the T 1 lineage transcription factor T-bet has been identified as a defining feature of ABC biology, with B cell-intrinsic expression of this transcription factor proposed to be required for ABC formation. In contrast to this model, we report that Tbx21 (encoding T-bet)-deficient B cells upregulate CD11b and CD11c surface expression in vitro in response to integrated TLR and cytokine signals. Read More

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http://dx.doi.org/10.1002/eji.201847641DOI Listing
January 2019
12 Reads

Staphylococcus aureus osteoarticular infections in children: an 8-year review of molecular microbiology, antibiotic resistance and clinical characteristics.

J Med Microbiol 2018 Dec 23;67(12):1753-1760. Epub 2018 Oct 23.

4​First Department of Pediatrics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.

Purpose: To investigate the clinical, phenotypic and genotypic characteristics of Staphylococcus aureus strains causing osteoarticular infections in a large paediatric series.

Methodology: Medical records of children who were hospitalized with the diagnosis of community-associated S. aureus (CA-SA) osteomyelitis and/or septic arthritis in the two major tertiary paediatric hospitals of Athens during an 8-year period (2007-2015) were reviewed, and S. Read More

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http://dx.doi.org/10.1099/jmm.0.000859DOI Listing
December 2018
16 Reads

Sepsis and Pleural Empyema Caused by after Influenza A Virus Infection.

Case Rep Pediatr 2018 23;2018:4509847. Epub 2018 Sep 23.

Department of Pediatrics, Ehime University Graduate School of Medicine, Ehime, Toon, Japan.

(also referred to as group A streptococci, GAS) causes severe invasive diseases such as bacteremia, necrotizing fasciitis, pneumonia, osteomyelitis, septic arthritis, and toxic shock syndrome in children. However, there are only a few reports on pleural empyema caused by GAS in children. Here, we report the case of a 4-year-old boy who presented with pleural empyema due to GAS after influenza A virus infection. Read More

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http://dx.doi.org/10.1155/2018/4509847DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6174774PMC
September 2018
3 Reads

Discovery of tear biomarkers in children with chronic non-infectious anterior uveitis: a pilot study.

J Ophthalmic Inflamm Infect 2018 Oct 16;8(1):17. Epub 2018 Oct 16.

UCLA Stein Eye Institute and David Geffen School of Medicine at University of California, 100 Stein Plaza, Los Angeles, CA, 90095-7000, USA.

Background: Biomarkers in easily obtained specimens that accurately predict uveitis in children with juvenile idiopathic arthritis (JIA) are needed. Aqueous humor has been studied for biomarkers, but is not routinely available. We evaluated tears from children with chronic anterior uveitis (CAU) for biomarkers reported in aqueous humor. Read More

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http://dx.doi.org/10.1186/s12348-018-0156-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191408PMC
October 2018
2 Reads

Identification of a Structural Element in HIV-1 Gag Required for Virus Particle Assembly and Maturation.

MBio 2018 10 16;9(5). Epub 2018 Oct 16.

Virus-Cell Interaction Section, HIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, USA

Late in the HIV-1 replication cycle, the viral structural protein Gag is targeted to virus assembly sites at the plasma membrane of infected cells. The capsid (CA) domain of Gag plays a critical role in the formation of the hexameric Gag lattice in the immature virion, and, during particle release, CA is cleaved from the Gag precursor by the viral protease and forms the conical core of the mature virion. A highly conserved Pro-Pro-Ile-Pro (PPIP) motif (CA residues 122 to 125) [PPIP(122-125)] in a loop connecting CA helices 6 and 7 resides at a 3-fold axis formed by neighboring hexamers in the immature Gag lattice. Read More

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http://mbio.asm.org/lookup/doi/10.1128/mBio.01567-18
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http://dx.doi.org/10.1128/mBio.01567-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191540PMC
October 2018
18 Reads

Genetic correlations among psychiatric and immune-related phenotypes based on genome-wide association data.

Am J Med Genet B Neuropsychiatr Genet 2018 Oct 16;177(7):641-657. Epub 2018 Oct 16.

Psychiatric Genetic Epidemiology & Neurobiology Laboratory (PsychGENe Lab), Departments of Psychiatry and Behavioral Sciences & Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, New York.

Individuals with psychiatric disorders have elevated rates of autoimmune comorbidity and altered immune signaling. It is unclear whether these altered immunological states have a shared genetic basis with those psychiatric disorders. The present study sought to use existing summary-level data from previous genome-wide association studies to determine if commonly varying single nucleotide polymorphisms are shared between psychiatric and immune-related phenotypes. Read More

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http://doi.wiley.com/10.1002/ajmg.b.32652
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http://dx.doi.org/10.1002/ajmg.b.32652DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230304PMC
October 2018
13 Reads
3.420 Impact Factor

Short individualised treatment of bone and joint infections in Danish children.

Arch Dis Child 2019 Feb 13;104(2):205-206. Epub 2018 Oct 13.

Department of Paediatrics, University Hospital Naestved, Naestved, Denmark.

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http://dx.doi.org/10.1136/archdischild-2018-315734DOI Listing
February 2019
7 Reads

Treat to target (drug-free) inactive disease in DMARD-naive juvenile idiopathic arthritis: 24-month clinical outcomes of a three-armed randomised trial.

Ann Rheum Dis 2019 Jan 11;78(1):51-59. Epub 2018 Oct 11.

Department of Paediatric Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.

Question: Which is the best strategy to achieve (drug-free) inactive disease in juvenile idiopathic arthritis (JIA)?

Methods: In a randomised, single-blinded, study in disease-modifying anti-rheumatic drug (DMARD)-naive patients with JIA, three treatment-strategies were compared: (1) sequential DMARD-monotherapy (sulfasalazine or methotrexate (MTX)), (2) combination therapy MTX + 6 weeks prednisolone and (3) combination therapy MTX +etanercept. Treatment-to-target entailed 3-monthly DMARD/biological adjustments in case of persistent disease activity, with drug tapering to nil in case of inactive disease.After 24 months, primary outcomes were time-to-inactive-disease and time-to-flare after DMARD discontinuation. Read More

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http://dx.doi.org/10.1136/annrheumdis-2018-213902DOI Listing
January 2019
6 Reads

C-Reactive Protein Predicts Risk of Venous Thromboembolism in Pediatric Musculoskeletal Infection.

J Pediatr Orthop 2019 Jan;39(1):e62-e67

Departments of Orthopaedics and Rehabilitation.

Background: The rate of venous thromboembolism in children with musculoskeletal infections (MSKIs) is markedly elevated compared with hospitalized children in general. Predictive biomarkers to identify high-risk patients are needed to prevent the significant morbidity and rare mortality associated with thrombotic complications. We hypothesize that overactivation of the acute phase response is associated with the development of pathologic thrombi and we aim to determine whether elevations in C-reactive protein (CRP) are associated with increased rates of thrombosis in pediatric patients with MSKI. Read More

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http://Insights.ovid.com/crossref?an=01241398-201901000-0002
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http://dx.doi.org/10.1097/BPO.0000000000001256DOI Listing
January 2019
6 Reads

Case 1: 14-month-old Boy with Refusal to Bear Weight.

Pediatr Rev 2018 Oct;39(10):516-518

Department of Pediatrics, University of Kentucky, Kentucky Children's Hospital, Lexington, KY.

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http://dx.doi.org/10.1542/pir.2017-0258DOI Listing
October 2018
3 Reads

Imaging findings of sterile pyogenic arthritis, pyoderma gangrenosum and acne (PAPA) syndrome: differential diagnosis and review of the literature.

Pediatr Radiol 2019 01 17;49(1):23-36. Epub 2018 Sep 17.

Department of Diagnostic Imaging, The Hospital for Sick Children, Toronto, ON, Canada.

Pyogenic arthritis, pyoderma gangrenosum and acne (PAPA) syndrome is a rare autosomal-dominant autoinflammatory disease of incomplete penetrance and variable expression. PAPA syndrome is the result of a mutation in the proline serine threonine phosphatase-interacting protein 1 (PSTPIP1/CD2BP1) gene located on chromosome 15, which results in an abnormal overproduction of the pro-inflammatory cytokine interleukin-1β (IL-1). This syndrome clinically manifests as early onset of recurrent episodes of acute aseptic inflammation of the joints, generally occurring in the first two decades of life, followed by manifestation of characteristic skin lesions in the third decade, after an obvious decline in the joint symptoms. Read More

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http://dx.doi.org/10.1007/s00247-018-4246-1DOI Listing
January 2019
1 Read

PD-1+CD8+ T cells are clonally expanding effectors in human chronic inflammation.

J Clin Invest 2018 10 2;128(10):4669-4681. Epub 2018 Aug 2.

Department of Pediatrics, Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands.

Chronic inflammatory diseases are characterized by recurrent inflammatory attacks in the tissues mediated by autoreactive T cells. Identity and functional programming of CD8+ T cells at the target site of inflammation still remain elusive. One key question is whether, in these antigen-rich environments, chronic stimulation leads to CD8+ T cell exhaustion comparable to what is observed in infectious disease contexts. Read More

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http://dx.doi.org/10.1172/JCI96107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6159979PMC
October 2018
11 Reads
13.215 Impact Factor

Postpartum Depression and Subsequent Autoimmune Diseases in Taiwan.

Int J Environ Res Public Health 2018 08 20;15(8). Epub 2018 Aug 20.

Department of Obstetrics & Gynecology, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan.

Postpartum depression (PPD) is one of the most common examples of postnatal morbidity, but the subsequent risks of autoimmune diseases in patients with PPD have yet to be fully investigated. This nationwide population-based study utilized data of the National Health Insurance Research Database of Taiwan for the period from 1996 to 2013. In total, 45,451 women with primiparity were identified. Read More

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http://dx.doi.org/10.3390/ijerph15081783DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121646PMC
August 2018
14 Reads

Clinical practice guidance for juvenile idiopathic arthritis (JIA) 2018.

Mod Rheumatol 2019 Jan 29;29(1):41-59. Epub 2018 Oct 29.

k Department of Lifetime Clinical Immunology, Graduate School of Medical and Dental Sciences , Tokyo Medical and Dental University , Tokyo , Japan.

Juvenile idiopathic arthritis (JIA) is the most common disease in pediatric rheumatism. There is no specific symptom or examination finding for JIA, and the diagnosis is made by exclusion and differentiation. Because non-pediatric rheumatologists are sometimes involved in medical care, 'proposal for JIA guidance on diagnosis and treatment for primary care pediatricians and non-pediatric rheumatologists' was first published in 2007. Read More

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http://dx.doi.org/10.1080/14397595.2018.1514724DOI Listing
January 2019
28 Reads

Outcomes of non-infectious Paediatric uveitis in the era of biologic therapy.

Pediatr Rheumatol Online J 2018 Aug 6;16(1):51. Epub 2018 Aug 6.

University Hospitals Bristol NHS Foundation Trust, Bristol, UK.

Background: There is a paucity of data on the ocular outcomes in paediatric non-infectious uveitis since the introduction of the biologic agents. The purpose of this study was to outline the clinical characteristics of children with non-infectious uveitis and determine the visual outcomes and ocular complication rates in the modern era.

Methods: Children with non-infectious uveitis from January 2011 to December 2015 were identified. Read More

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http://dx.doi.org/10.1186/s12969-018-0266-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080499PMC
August 2018
21 Reads

Symptom Resolution in Pediatric Patients With Lyme Disease.

J Pediatric Infect Dis Soc 2018 Jul 30. Epub 2018 Jul 30.

Department of Pediatric Infectious Diseases, Children's National Health System, Washington, DC.

We performed a retrospective study to determine the time frame for symptom resolution in 78 pediatric patients hospitalized with laboratory-confirmed early-disseminated or late-stage Lyme disease. The vast majority of the patients improved promptly after receiving appropriate antibiotics. Patients with a longer duration of arthritis before the institution of therapy experienced a longer time to recovery. Read More

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https://academic.oup.com/jpids/advance-article/doi/10.1093/j
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http://dx.doi.org/10.1093/jpids/piy067DOI Listing
July 2018
10 Reads

Irritable Hip as the Inaugural Symptom for Neuroblastoma.

Case Rep Orthop 2018 28;2018:7428350. Epub 2018 Jun 28.

Pediatrics Department, Centro Hospitalar Tâmega e Sousa, Guilhufe, Portugal.

Case Report: A four-year-old girl presented with fever and a painful limp in the left hip. Pain characteristics and anemia detected in the blood analyses were the first warning signs that the hip process was not standard. Although the primary suspicion was of septic arthritis, a CT scan of the abdomen revealed an adrenal neuroblastoma. Read More

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http://dx.doi.org/10.1155/2018/7428350DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6046166PMC
June 2018
1 Read

EPIDEMIOLOGICAL STUDY OF OSTEOARTICULAR INFECTIONS IN CHILDREN.

Acta Ortop Bras 2018 May-Jun;26(3):201-205

. Orthopedics and Traumatology Group at the Mandaqui Hospital Complex, São Paulo, SP, Brazil.

Objective: To analyze the characteristics of patients diagnosed with pediatric osteoarticular infections treated in a level III trauma center in São Paulo, Brazil.

Methods: We retrospectively analyzed patients admitted between September 2012 and August 2014. The outcomes analyzed were: age, sex, diagnosis, etiologic agent, anatomic location, time to diagnosis, history of previous trauma and infection, laboratory tests, treatment, and complications. Read More

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http://dx.doi.org/10.1590/1413-785220182603145650DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053965PMC
July 2018
5 Reads

Systemic Juvenile Idiopathic Arthritis.

Pediatr Clin North Am 2018 08;65(4):691-709

Department of Paediatrics, Division of Rheumatology, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada. Electronic address:

Systemic juvenile idiopathic arthritis (sJIA) is a distinctive subtype of juvenile idiopathic arthritis, characterized by fever and arthritis, often accompanied by rash, sometimes by generalized lymphadenopathy, hepatosplenomegaly, and serositis. The diagnosis requires adequate exclusion of infectious, oncologic, autoimmune, and autoinflammatory diseases. Macrophage activation syndrome, a serious and potentially fatal complication of sJIA, requires prompt evaluation and treatment. Read More

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http://dx.doi.org/10.1016/j.pcl.2018.04.005DOI Listing
August 2018
37 Reads

Kingella kingae Septic Arthritis in an Older-Than-Expected Child.

J Pediatric Infect Dis Soc 2019 Mar;8(1):83-86

Department of Children's Medical Center, University of Texas Southwestern, Dallas.

Kingella kingae typically causes musculoskeletal infection in young children between the ages of 6 months and 4 years who may be in close contact with other similarly aged children who are colonized with the organism in their oropharynx. Kingella infections have rarely been described in older individuals with chronic medical conditions or immune compromise. This is a case report of a healthy, older child who developed an invasive infection due to Kingella kingae. Read More

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http://dx.doi.org/10.1093/jpids/piy063DOI Listing
March 2019
5 Reads

Performance of TEM-PCR vs Culture for Bacterial Identification in Pediatric Musculoskeletal Infections.

Open Forum Infect Dis 2018 Jun 22;5(6):ofy119. Epub 2018 May 22.

Division of Pediatric Infectious Diseases, Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee.

Improved diagnostics are needed for children with musculoskeletal infections (MSKIs). We assessed the performance of target-enriched multiplex polymerase chain reaction (TEM-PCR) in children with MSKI. TEM-PCR was concordant with culture in pathogen identification and antibiotic susceptibility testing, while increasing the overall yield of pathogen detection. Read More

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http://dx.doi.org/10.1093/ofid/ofy119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007387PMC
June 2018
3 Reads

Kawasaki Disease in the neonate: case report and literature review.

Pediatr Rheumatol Online J 2018 Jul 3;16(1):43. Epub 2018 Jul 3.

Division of Rheumatology, Department of Pediatrics, IWK Health Centre, Dalhousie University, 5980 University Ave, Halifax, NS, B3K 6R8, Canada.

Background: Kawasaki Disease (KD), the leading cause of acquired heart disease in children in the developed world, is extremely rare in neonates. We present a case of incomplete KD in a neonate and a review of the literature on neonatal KD.

Case Presentation: A previously healthy full term 15 day old Caucasian male with an unremarkable antenatal and perinatal history, presented on Day 2 of illness with fever, rash, irritability, and poor feeding. Read More

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http://dx.doi.org/10.1186/s12969-018-0263-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6029347PMC
July 2018
4 Reads

Managing pulmonary embolism secondary to suppurative deep vein thrombophlebitis due to community-acquired in a resource-poor setting.

J Postgrad Med 2018 Jul-Sep;64(3):164-169

Department of Pediatrics, Seth G.S. Medical College and KEM Hospital, Mumbai, Maharashtra, India.

Deep vein thrombosis and pulmonary thromboembolism are rare and life threatening emergencies in children. We report an 11-year old female who presented with acute complaints of high grade fever, pain in the left thigh and inability to walk and breathlessness since 6 days. On physical examination, there was a diffuse tender swelling of the left thigh, tachypnea, tachycardia with hyperdynamic precordium and bilateral basal crepitations. Read More

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http://dx.doi.org/10.4103/jpgm.JPGM_548_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6066628PMC
June 2018
9 Reads

Clinical features of paediatric uveitis at a tertiary referral centre in São Paulo, SP, Brazil.

Br J Ophthalmol 2018 Jun 15. Epub 2018 Jun 15.

Department of Ophthalmology, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil.

Aims: To analyse the clinical features, systemic associations, treatment and visual outcomes of uveitis in children from a referral centre in São Paulo, Brazil.

Methods: Clinical records of patients under 16 years old who attended the Uveitis Service, Hospital das Clinicas, Faculdadede Medicina, Universidade de São PauloFMUSP, between April and September 2017, were reviewed retrospectively. Patients with incomplete medical records, previous ocular trauma, or less than six6 months of follow-up were excluded. Read More

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http://bjo.bmj.com/lookup/doi/10.1136/bjophthalmol-2018-3123
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http://dx.doi.org/10.1136/bjophthalmol-2018-312313DOI Listing
June 2018
11 Reads