1,029 results match your criteria Septic Arthritis Pediatrics

Influence of Genetics, Immunity and the Microbiome on the Prognosis of Inflammatory Bowel Disease (IBD Prognosis Study): the protocol for a Copenhagen IBD Inception Cohort Study.

BMJ Open 2022 Jun 27;12(6):e055779. Epub 2022 Jun 27.

Department of Periodontology, Malmö Universitet, Malmo, Sweden.

Introduction: Inflammatory bowel diseases (IBD), encompassing Crohn's disease and ulcerative colitis, are chronic, inflammatory diseases of the gastrointestinal tract. We have initiated a Danish population-based inception cohort study aiming to investigate the underlying mechanisms for the heterogeneous course of IBD, including need for, and response to, treatment.

Methods And Analysis: IBD Prognosis Study is a prospective, population-based inception cohort study of unselected, newly diagnosed adult, adolescent and paediatric patients with IBD within the uptake area of Hvidovre University Hospital and Herlev University Hospital, Denmark, which covers approximately 1 050 000 inhabitants (~20% of the Danish population). Read More

View Article and Full-Text PDF

Systemic Juvenile Idiopathic Arthritis in two children; case report on clinical course, challenges in diagnosis and the role of FDG-PET/CT-scan.

Clin Case Rep 2022 Jun 13;10(6):e05900. Epub 2022 Jun 13.

Department of Paediatrics Dijklander Hospital Hoorn Hoorn The Netherlands.

Systemic juvenile idiopathic arthritis (sJIA, also called Still's disease) is a rare childhood auto-inflammatory disease with significant morbidity. This case report illustrates the clinical course and highlights diagnostic challenges. FDG-PET/CT imaging may be beneficial in the diagnostic process for some cases, in order to achieve rapid diagnosis and early treatment. Read More

View Article and Full-Text PDF

EULAR/PRES recommendations for vaccination of paediatric patients with autoimmune inflammatory rheumatic diseases: update 2021.

Ann Rheum Dis 2022 Jun 20. Epub 2022 Jun 20.

RITA, European Reference Networks, Brussels, Belgium.

Objectives: Recent insights supporting the safety of live-attenuated vaccines and novel studies on the immunogenicity of vaccinations in the era of biological disease-modifying antirheumatic drugs in paediatric patients with autoimmune/inflammatory rheumatic diseases (pedAIIRD) necessitated updating the EULAR recommendations.

Methods: Recommendations were developed using the EULAR standard operating procedures. Two international expert committees were formed to update the vaccination recommendations for both paediatric and adult patients with AIIRD. Read More

View Article and Full-Text PDF

Risk of hepatitis B virus reactivation following treatment with abatacept: A retrospective study of international pharmacovigilance databases.

EClinicalMedicine 2022 Jun 5;48:101425. Epub 2022 May 5.

Department of Infectious Diseases, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

Background: Abatacept is a selective T-cell costimulation modulator approved for the treatment of rheumatoid arthritis, juvenile idiopathic arthritis, and psoriatic arthritis. Reports were recently published on hepatitis B virus reactivation (HBVr) in patients who were treated with abatacept. However, the literature is limited to case reports and series, and no study has investigated the relationship between HBVr and abatacept using extensive population-based databases. Read More

View Article and Full-Text PDF

Pediatric Reactive Arthritis Due to Infection.

Clin Pediatr (Phila) 2022 Jun 8:99228221098977. Epub 2022 Jun 8.

Department of Pediatrics, Children's Hospital Los Angeles, Los Angeles, CA, USA.

View Article and Full-Text PDF

Toward a Better Understanding of the Atypical Features of Chronic Graft-Versus-Host Disease: A Report from the 2020 National Institutes of Health Consensus Project Task Force.

Transplant Cell Ther 2022 May 31. Epub 2022 May 31.

Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany.

Alloreactive and autoimmune responses after allogeneic hematopoietic cell transplantation can occur in nonclassical chronic graft-versus-host disease (chronic GVHD) tissues and organ systems or manifest in atypical ways in classical organs commonly affected by chronic GVHD. The National Institutes of Health (NIH) consensus projects were developed to improve understanding and classification of the clinical features and diagnostic criteria for chronic GVHD. Although still speculative whether atypical manifestations are entirely due to chronic GVHD, these manifestations remain poorly captured by the current NIH consensus project criteria. Read More

View Article and Full-Text PDF

Bilateral hip septic arthritis caused by nontyphoidal Salmonella group D in a 16-year-old girl with COVID-19: A case report.

Int J Surg Case Rep 2022 Jun 17;95:107202. Epub 2022 May 17.

Central Laboratory, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Introduction And Importance: Nontyphoidal Salmonella infection can lead to gastroenteritis, enteric fever, and bacteremia. However, joint infections due to this bacterium are rare, and usually associated with immunosuppressive disorders.

Case Presentation: A 16-year-old girl, with a recent history of acute lymphocytic leukemia (ALL) presented with bacteremia, and bilateral hip pain after COVID-19 symptoms. Read More

View Article and Full-Text PDF

Association between forkhead box P3 expression level and gender of Iranian juvenile idiopathic arthritis patients.

Reumatologia 2022 28;60(1):26-34. Epub 2022 Feb 28.

Pediatric Infectious Research Center, Mofid Children's Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Objectives: Juvenile idiopathic arthritis (JIA) is a childhood autoimmune rheumatoid disease. Past studies have confirmed that JIA is a complex disease, which means that genes and environmental factors affect the aetiology of the disease. In this study, we analysed the expression of interleukin 32, forkhead box P3 (FOXP3), methyl-CpG binding domain protein 1 (MBD1), and methyl-CpG-binding protein 2 (MECP2) in peripheral blood mononuclear cells of children with JIA in comparison with the expression of those in healthy children. Read More

View Article and Full-Text PDF
February 2022

A Clinical Prediction Rule for Bacterial Musculoskeletal Infections in Children with Monoarthritis in Lyme Endemic Regions.

Ann Emerg Med 2022 May 25. Epub 2022 May 25.

Division of Emergency Medicine, Boston Children's Hospital and Harvard Medical School, Boston, MA.

Study Objective: Children with a bacterial musculoskeletal infection (MSKI) require prompt identification and treatment. In Lyme disease endemic areas, children with an MSKI can present similarly to those with Lyme arthritis. Our goal was to derive a clinical prediction rule to accurately identify children at a low risk for an MSKI. Read More

View Article and Full-Text PDF

Identifying predictors for source culture positivity in children with acute musculoskeletal infections.

Diagnosis (Berl) 2022 May 30. Epub 2022 May 30.

Department of Pediatrics, Section of Infectious Diseases, University of Colorado, Aurora, CO, USA.

Objectives: Identifying the causative bacterial pathogen for children with acute hematogenous musculoskeletal infections (MSKIs) allows for improved care. The purpose of our study was to determine if clinical markers could predict which patients will have a causative pathogen found on source culture alone, thus being highest yield to undergo operative diagnostic procedures.

Methods: A single-center, retrospective cohort study was performed. Read More

View Article and Full-Text PDF

Osteoarticular Infections in Pediatric Hospitals in Europe: A Prospective Cohort Study From the EUCLIDS Consortium.

Front Pediatr 2022 4;10:744182. Epub 2022 May 4.

Department of Pediatrics and Adolescent Medicine, Division of General Pediatrics, Medical University of Graz, Graz, Austria.

Background: Pediatric osteoarticular infections (POAIs) are serious diseases requiring early diagnosis and treatment.

Methods: In this prospective multicenter cohort study, children with POAIs were selected from the European Union Childhood Life-threatening Infectious Diseases Study (EUCLIDS) database to analyze their demographic, clinical, and microbiological data.

Results: A cohort of 380 patients with POAIs, 203 with osteomyelitis (OM), 158 with septic arthritis (SA), and 19 with both OM and SA, was analyzed. Read More

View Article and Full-Text PDF

ACR Appropriateness Criteria® Osteomyelitis or Septic Arthritis-Child (Excluding Axial Skeleton).

J Am Coll Radiol 2022 05;19(5S):S121-S136

Specialty Chair, Department of Medical Imaging, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois.

Imaging plays an integral role in the evaluation of suspected musculoskeletal infections in children, not only in the accurate identification of infection such as osteomyelitis or septic arthritis, but also in guiding management. Various diagnostic modalities serve different purposes in the assessment of suspected pediatric musculoskeletal infections. The purpose of this document is to provide imaging guidance in the most frequently encountered clinical scenarios in which osteomyelitis and/or septic arthritis are suspected, outside of the axial skeleton. Read More

View Article and Full-Text PDF

Neutrophil phenotypes and functions in cancer: A consensus statement.

J Exp Med 2022 06 6;219(6). Epub 2022 May 6.

Department of Pharmacology and Physiology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

Neutrophils are the first responders to infection and inflammation and are thus a critical component of innate immune defense. Understanding the behavior of neutrophils as they act within various inflammatory contexts has provided insights into their role in sterile and infectious diseases; however, the field of neutrophils in cancer is comparatively young. Here, we summarize key concepts and current knowledge gaps related to the diverse roles of neutrophils throughout cancer progression. Read More

View Article and Full-Text PDF

An 8-Year-Old Boy With Prolonged Fever and Subcutaneous Nodules.

Pediatrics 2022 05;149(5)

Hospital Medicine, Department of Pediatrics, Children's Hospital Los Angeles.

An 8-year-old boy with asthma presented with prolonged fever, malaise, extremity weakness, polyarthralgias, malar rash, and subcutaneous nodules. Physical examination was remarkable for a faint malar rash, flesh-colored papules on the dorsal aspect of the fingers, arthritis of multiple joints in the hands, and subcutaneous nodules. The nodules were firm, nontender, and distributed over multiple extremities and the trunk. Read More

View Article and Full-Text PDF

Development and Implementation of the AIDA International Registry for Patients With Still's Disease.

Front Med (Lausanne) 2022 7;9:878797. Epub 2022 Apr 7.

Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.

Objective: Aim of this paper is to present the design, construction, and modalities of dissemination of the AutoInflammatory Disease Alliance (AIDA) International Registry for patients with systemic juvenile idiopathic arthritis (sJIA) and adult-onset Still's disease (AOSD), which are the pediatric and adult forms of the same autoinflammatory disorder.

Methods: This Registry is a clinical, physician-driven, population- and electronic-based instrument implemented for the retrospective and prospective collection of real-world data. The collection of data is based on the Research Electronic Data Capture (REDCap) tool and is intended to obtain evidence drawn from routine patients' management. Read More

View Article and Full-Text PDF

TNF-inhibitors or bisphosphonates in chronic nonbacterial osteomyelitis? - Results of an international retrospective multicenter study.

Clin Immunol 2022 05 20;238:109018. Epub 2022 Apr 20.

Department of Rheumatology, Alder Hey Children's NHS Foundation Trust, Liverpool, United Kingdom; Department of Women's and Children's Health, Institute of Life Course and Medical Sciences, University of Liverpool, United Kingdom. Electronic address:

Chronic nonbacterial osteomyelitis (CNO) can cause significant morbidity, including bone pain and damage. In the absence of clinical trials, treatments include non-steroidal anti-inflammatory drugs, corticosteroids, TNF-inhibitors (TNFi) and/or bisphosphonates. In a retrospective chart review in the United Kingdom and Germany, we investigated response to TNFi and/or pamidronate. Read More

View Article and Full-Text PDF

A Rare Presentation of Infective Endocarditis Due to Serratia marcescens.

Cureus 2022 Mar 7;14(3):e22936. Epub 2022 Mar 7.

Department of Internal Medicine and Pediatrics, Rutgers University New Jersey Medical School, Newark, USA.

is an opportunistic organism that can commonly cause respiratory tract infections in immunocompromised individuals. It has also been shown to cause urinary tract infections and soft tissue infections. It has several virulence factors including fimbriae-like adhesions that allow for surface attachment and biofilm formation to increase the likelihood of infections in humans. Read More

View Article and Full-Text PDF

Safety of SARS-CoV-2 vaccination in patients with Behcet's syndrome and familial Mediterranean fever: a cross-sectional comparative study on the effects of M-RNA based and inactivated vaccine.

Rheumatol Int 2022 06 4;42(6):973-987. Epub 2022 Apr 4.

Division of Rheumatology, Department of Internal Medicine, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Istanbul, Turkey.

Most of the published data relate to classical forms of rheumatic diseases (RD) and information on rare inflammatory disorders such as Behçet's syndrome (BS) and familial Mediterranean fever (FMF) is limited. We studied the frequency of side effects and disease flares after COVID-19 vaccination with either Pfizer/BioNTech or Sinovac/CoronaVac in 256 patients with BS, 247 with FMF, and 601 with RD. Telephone interviews were conducted using a questionnaire survey in a cross-sectional design in patients with BS, FMF, and RD followed by a single university hospital. Read More

View Article and Full-Text PDF

Obturator pyomyositis and labium majus cellulitis: A case report and literature review.

SAGE Open Med Case Rep 2022 25;10:2050313X211063781. Epub 2022 Mar 25.

Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan.

Pyomyositis is a rare, subacute, deep bacterial infection of the skeletal muscle. When treatment is delayed, pyomyositis causes abscess formation and progresses to sepsis; therefore, its early diagnosis is important. However, the clinical presentation and laboratory findings of pyomyositis are not specific; hence, diagnosis often takes time. Read More

View Article and Full-Text PDF

Septic Arthritis in Pediatric Hemophilia A: A Case Report and Review of Literature.

Indian J Orthop 2022 Apr 23;56(4):705-715. Epub 2021 Nov 23.

Department of Orthopaedics, Silchar Medical College & Hospital, Ghungoor road, beside Indian Post, Silchar, 788014 Assam India.

Hemophilia A is a hereditary bleeding disorder due to coagulation factor VIII deficiency. Septic arthritis is in itself a dreaded infective condition of the joint. It is much more common in hemophilia patients than the general population and is associated with considerably higher morbidity. Read More

View Article and Full-Text PDF

Synovial signal intensity on static contrast-enhanced MRI for evaluation of disease activity in juvenile idiopathic arthritis - A look at the bright side of the knee.

Clin Imaging 2022 Jun 19;86:53-60. Epub 2022 Mar 19.

Radiology and Nuclear Medicine, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam Movement Sciences, Meibergdreef 9, 1105 AZ Amsterdam, the Netherlands.

Background: Knowledge on the role of synovial signal intensity (SI) grading on static contrast-enhanced (CE) MRI of the knee for assessment of disease activity in juvenile idiopathic arthritis (JIA) is lacking.

Objectives: To assess the value of synovial SI on static CE-MRI of the knee for evaluation of disease activity in children with JIA.

Materials And Methods: Children with clinically inactive and clinically active JIA who underwent static CE-MRI of the knee were included. Read More

View Article and Full-Text PDF

Outcomes of SARS-CoV-2 infection among children and young people with pre-existing rheumatic and musculoskeletal diseases.

Ann Rheum Dis 2022 Mar 25. Epub 2022 Mar 25.

Centre for Epidemiology Versus Arthritis, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK

Objectives: Some adults with rheumatic and musculoskeletal diseases (RMDs) are at increased risk of COVID-19-related death. Excluding post-COVID-19 multisystem inflammatory syndrome of children, children and young people (CYP) are overall less prone to severe COVID-19 and most experience a mild or asymptomatic course. However, it is unknown if CYP with RMDs are more likely to have more severe COVID-19. Read More

View Article and Full-Text PDF

Developments in diagnosis and treatment of paediatric septic arthritis.

World J Orthop 2022 Feb 18;13(2):122-130. Epub 2022 Feb 18.

Department of Orthopedic Surgery, Amphia Hospital, Breda 4818 CK, Netherlands.

Acute septic arthritis in children is an orthopaedic emergency. A delay in diagnosis and inappropriate treatment can result in devastating damage to the joint with lifelong disability as a consequence. The clinical presentation can be a diagnostic challenge, especially in young children. Read More

View Article and Full-Text PDF
February 2022

Association of Corticosteroid Treatment With Outcomes in Pediatric Patients With Bacterial Meningitis: A Systematic Review and Meta-analysis of Randomized Controlled Trials.

Clin Ther 2022 04 7;44(4):551-564. Epub 2022 Mar 7.

Department of Pharmacy, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. Electronic address:

Purpose: Controversy has arisen among the overall benefit and potential risks in the use of corticosteroids for the treatment of pediatric bacterial meningitis. This systematic review and meta-analysis aims to provide evidence of the use of corticosteroids in the treatment of bacterial meningitis in children.

Methods: Electronic databases (PubMed, Embase, Cochrane Central Register of Controlled Trials, and other databases) were searched from inception until March 9, 2021. Read More

View Article and Full-Text PDF

Bacterial and Host Determinants of Group B Streptococcal Infection of the Neonate and Infant.

Front Microbiol 2022 21;13:820365. Epub 2022 Feb 21.

Department of Global Health, University of Washington, Seattle, WA, United States.

Group B streptococci (GBS) are Gram-positive β-hemolytic bacteria that can cause serious and life-threatening infections in neonates manifesting as sepsis, pneumonia, meningitis, osteomyelitis, and/or septic arthritis. Invasive GBS infections in neonates in the first week of life are referred to as early-onset disease (EOD) and thought to be acquired by the fetus through exposure to GBS or to vaginal fluids during birth. Late-onset disease (LOD) refers to invasive GBS infections between 7 and 89 days of life. Read More

View Article and Full-Text PDF
February 2022

Multicenter analysis of neutrophil extracellular trap dysregulation in adult and pediatric COVID-19.

medRxiv 2022 Mar 3. Epub 2022 Mar 3.

Programa de Inmunogenética e Inmunología Traslacional, Instituto de Ciencias e Innovación en Medicina, Facultad de Medicina Clínica Alemana, Universidad del Desarrollo, Santiago, Chile.

Dysregulation in neutrophil extracellular trap (NET) formation and degradation may play a role in the pathogenesis and severity of COVID-19; however, its role in the pediatric manifestations of this disease including MIS-C and chilblain-like lesions (CLL), otherwise known as "COVID toes", remains unclear. Studying multinational cohorts, we found that, in CLL, NETs were significantly increased in serum and skin. There was geographic variability in the prevalence of increased NETs in MIS-C, in association with disease severity. Read More

View Article and Full-Text PDF

Genetic Susceptibility to Enteric Fever in Experimentally Challenged Human Volunteers.

Infect Immun 2022 04 7;90(4):e0038921. Epub 2022 Mar 7.

Oxford Vaccine Group, Department of Paediatrics, University of Oxfordgrid.4991.5 and the NIHR Oxford Biomedical Research Centre, Oxford, United Kingdom.

Infections with Salmonella enterica serovars Typhi and Paratyphi A cause an estimated 14 million cases of enteric fever annually. Here, the controlled nature of challenge studies is exploited to identify genetic variants associated with enteric fever susceptibility. Human challenge participants were genotyped by Illumina OmniExpress-24 BeadChip array ( = 176) and/or transcriptionally profiled by RNA sequencing ( = 174). Read More

View Article and Full-Text PDF

New Perspectives on Diagnosing Psoriatic Arthritis by Imaging Techniques.

Open Access Rheumatol 2021 22;13:343-352. Epub 2021 Dec 22.

Faculty of Medicine and Pharmacy, Clinical Department, Medical and Pharmaceutical Research Unit/Competitive, Interdisciplinary Research Integrated Platform', ReForm-UDJG, "Dunarea de Jos" University, Galati, Romania.

Psoriatic arthritis is a chronic inflammatory condition that can lead to severe functional impairment and irreversible damage. The diagnosis can be difficult in early cases where the clinical exam is often scarce. The lack of a serological biomarker can lead to a considerable delay in diagnosis. Read More

View Article and Full-Text PDF
December 2021

Infections With Enterohepatic Non- Species in X-Linked Agammaglobulinemia: Clinical Cases and Review of the Literature.

Front Cell Infect Microbiol 2021 4;11:807136. Epub 2022 Feb 4.

Immunodeficiency Research Unit, National Institute of Pediatrics, Mexico City, Mexico.

The genus is classified into two main groups according to its habitat: gastric and enterohepatic. Patients with X-linked agammaglobulinemia (XLA) appear to be associated with invasive infection with enterohepatic non-Helicobacter pylori species (NHPH), mainly and . Such infections are difficult to control and have a high potential for recurrence. Read More

View Article and Full-Text PDF

Associations of lymphocyte subpopulations with clinical phenotypes and long-term outcomes in juvenile-onset systemic lupus erythematosus.

PLoS One 2022 7;17(2):e0263536. Epub 2022 Feb 7.

Faculty of Medicine Ramathibodi Hospital, Division of Rheumatology, Department of Pediatrics, Mahidol University, Bangkok, Thailand.

Objective: Juvenile-onset systemic lupus erythematosus (JSLE) is a complex and heterogeneous immune-mediated disease. Cellular components have crucial roles in disease phenotypes and outcomes. We aimed to determine the associations of lymphocyte subsets with clinical manifestations and long-term outcomes in JSLE patients. Read More

View Article and Full-Text PDF