21,136 results match your criteria Septic Arthritis


Sjogren's syndrome: An update on disease pathogenesis, clinical manifestations and treatment.

Clin Immunol 2019 Apr 22. Epub 2019 Apr 22.

Division of Allergy, Immunology and Rheumatology, SUNY at Buffalo School of Medicine, 100 High Street, Buffalo, NY 14203, USA. Electronic address:

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http://dx.doi.org/10.1016/j.clim.2019.04.009DOI Listing

Activation of Mast Cells Mediates Inflammatory Response in Psoriasis: Potential New Therapeutic Approach with IL-37.

Dermatol Ther 2019 Apr 22:e12943. Epub 2019 Apr 22.

Department of Microbiology and Infectious Diseases, Aristotle University of Thessaloniki, Macedonia, Greece.

Psoriasis (PS) is an autoimmune disorder characterized by chronic inflammatory skin immune-mediated disease which occurs in 2-4% of the worldwide population. PS is associated with an increased risk of cardiovascular disease and depression, and 30% of PS patients are affected with psoriatic arthritis. PS presents excessive keratinocyte proliferation, abnormal differentiation, and elevated mast cell (MC) number. Read More

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http://dx.doi.org/10.1111/dth.12943DOI Listing

Risk factors associated with revision for prosthetic joint infection following knee replacement: an observational cohort study from England and Wales.

Lancet Infect Dis 2019 Apr 17. Epub 2019 Apr 17.

Musculoskeletal Research Unit, Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK; National Institute for Health Research Bristol Biomedical Research Centre, University Hospitals Bristol NHS Foundation Trust and University of Bristol, Bristol, UK. Electronic address:

Background: Prosthetic joint infection is a devastating complication of knee replacement. The risk of developing a prosthetic joint infection is affected by patient, surgical, and health-care system factors. Existing evidence is limited by heterogeneity in populations studied, short follow-up, inadequate power, and does not differentiate early prosthetic joint infection, most likely related to the intervention, from late infection, more likely to occur due to haematogenous bacterial spread. Read More

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http://dx.doi.org/10.1016/S1473-3099(18)30755-2DOI Listing

Association Between Homocysteine Serum Level and Bone Mineral Density in Patients With Rheumatoid Arthritis.

J Clin Densitom 2019 Mar 28. Epub 2019 Mar 28.

Systemic Autoimmune Diseases Unit, Department of Internal Medicine, Hospital Universitario San Cecilio, Granada, Spain.

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http://dx.doi.org/10.1016/j.jocd.2019.03.008DOI Listing

Borrelia burgdorferi basic membrane protein A initiates proinflammatory chemokine storm in THP 1-derived macrophages via the receptors TLR1 and TLR2.

Biomed Pharmacother 2019 Apr 16;115:108874. Epub 2019 Apr 16.

Department of Biochemistry and Molecular Biology, Kunming Medical University, Kunming 650500, China.

Lyme disease, reffered to as Lyme borreliosis, is a tick-borne zoonotic disease caused by Borrelia burgdorferi spirochetes. Lyme arthritis, the most common, serious and harmful manifestation during the late stages of Lyme disease, is closely associated with the Borrelia burgdorferi basic membrane protein A (BmpA). Chemokines are also reported to have an important role in Lyme arthritis. Read More

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http://dx.doi.org/10.1016/j.biopha.2019.108874DOI Listing
April 2019
2 Reads

Evaluation of pneumococcal and tetanus vaccine responses in patients with rheumatoid arthritis receiving baricitinib: results from a long-term extension trial substudy.

Arthritis Res Ther 2019 Apr 18;21(1):102. Epub 2019 Apr 18.

Eli Lilly and Company, Indianapolis, IN, USA.

Background: Clinical guidelines recommend pneumococcal and tetanus vaccinations in patients with rheumatoid arthritis (RA). Baricitinib is an oral, selective Janus kinase (JAK) 1/JAK 2 inhibitor and is approved for the treatment of moderately to severely active RA in adults in over 50 countries including European countries, the USA, and Japan. This substudy evaluated pneumococcal conjugate and tetanus toxoid vaccine (TTV) responses in patients with RA receiving baricitinib. Read More

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http://dx.doi.org/10.1186/s13075-019-1883-1DOI Listing

Invasive Salmonella infections among children in Bintulu, Sarawak, Malaysian Borneo: a 6-year retrospective review.

BMC Infect Dis 2019 Apr 18;19(1):330. Epub 2019 Apr 18.

Institute of Health and Community Medicine, Universiti Malaysia Sarawak, Kota Samarahan, Sarawak, Malaysia.

Background: Invasive Salmonella infections result in significant morbidity and mortality in developing countries. In Asia, typhoid and paratyphoid fever are reported to be the major invasive Salmonella infections, while invasive non-typhoidal Salmonella (iNTS) infections are believed to be uncommon. Data from Sarawak, in Malaysian Borneo, are limited. Read More

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https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
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http://dx.doi.org/10.1186/s12879-019-3963-xDOI Listing
April 2019
1 Read
2.613 Impact Factor

Tofacitinib for the treatment of rheumatoid arthritis: an update.

Authors:
Kunihiro Yamaoka

Expert Rev Clin Immunol 2019 Apr 18. Epub 2019 Apr 18.

a Department of Rheumatology and Infectious Diseases , Kitasato University School of Medicine , 1-15-1 Kitasato, Minami-ku, Sagamihara , Kanagawa , 252-0374 Japan.

Introduction: Tofacitinib selectively inhibits the Janus kinases, intracellular tyrosine kinases that are activated by cytokines involved in the pathophysiology of rheumatoid arthritis. Areas covered: Clinical trials of tofacitinib have revealed an anti-rheumatic effect of monotherapy and combination therapy with methotrexate (MTX). Post-hoc analysis of those clinical trials and real-world experiences will be reviewed to explore tofacitinib's efficacy and safety. Read More

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https://www.tandfonline.com/doi/full/10.1080/1744666X.2019.1
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http://dx.doi.org/10.1080/1744666X.2019.1607298DOI Listing
April 2019
2 Reads

Two weeks versus four weeks of antibiotic therapy after surgical drainage for native joint bacterial arthritis: a prospective, randomised, non-inferiority trial.

Ann Rheum Dis 2019 Apr 16. Epub 2019 Apr 16.

Service of Infectious Diseases, Hopitaux Universitaires de Geneve, Geneva, Switzerland

Objective: The optimal duration of postsurgical antibiotic therapy for adult native joint bacterial arthritis remains unknown.

Methods: We conducted a prospective, unblinded, randomised, non-inferiority study comparing either 2 or 4 weeks of antibiotic therapy after surgical drainage of native joint bacterial arthritis in adults. Excluded were implant-related infections, episodes without surgical lavage and episodes with a follow-up of less than 2 months. Read More

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http://dx.doi.org/10.1136/annrheumdis-2019-215116DOI Listing
April 2019
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Value of serum procalcitonin for the diagnosis of bacterial septic arthritis in daily practice in rheumatology.

Clin Rheumatol 2019 Apr 16. Epub 2019 Apr 16.

CHRU Jean Minjoz, Service de Rhumatologie, 3 Boulevard Alexandre Fleming, 25000, Besancon, France.

Introduction/objectives: Septic arthritis is a diagnostic and therapeutic emergency because of a high morbidity and mortality. Nevertheless, the etiologic diagnosis is often difficult. The aim of our study was to determine if serum procalcitonin was a discriminatory biomarker in case of arthritis of undetermined etiology. Read More

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http://dx.doi.org/10.1007/s10067-019-04542-0DOI Listing
April 2019
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Osteosarcoma of the Proximal Femur Mimicking Septic Arthritis of the Hip: A diagnostic dilemma.

Sultan Qaboos Univ Med J 2018 Nov 28;18(4):e545-e548. Epub 2019 Mar 28.

Department of Orthopaedics, Armed Forces Hospital, Salalah, Oman.

Septic arthritis is a surgical emergency requiring prompt drainage of the accumulation of pus in the joint. We report an eight-year-old boy who was referred to the Armed Forces Hospital, Salalah, Oman, in 2016 with limping and pain in his right hip along with an abduction deformity. He was initially diagnosed with synovitis and underwent conservative management. Read More

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https://journals.squ.edu.om/index.php/squmj/article/view/300
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http://dx.doi.org/10.18295/squmj.2018.18.04.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443267PMC
November 2018
2 Reads

Comparison of efficacy and complications between two types of staging arthroplasty in treating chronic septic hip arthritis: A retrospective clinical study.

Exp Ther Med 2019 May 22;17(5):4123-4131. Epub 2019 Mar 22.

Department of Orthopedic Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian 350005, P.R. China.

Septic hip arthritis is a rare but serious disease, which is often persistent, able to transform into a chronic infection, and difficult to cure. The present study aimed to compare the midterm outcomes between the staging of a total hip arthroplasty via the Girdlestone surgery (a resection of the head and neck) and the Girdlestone combined with a cement spacer in treating chronic septic hip arthritis, as well as to compare the postsurgery efficacy and complications between the two groups. A total of 13 patients (14 total hip joints) were enrolled and retrospectively analyzed. Read More

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http://dx.doi.org/10.3892/etm.2019.7430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447925PMC

Report on the 2018 Cancer, Autoimmunity, and Immunology Conference.

J Immunol 2019 Apr 15. Epub 2019 Apr 15.

Cancer Therapy Evaluation Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892

With the increased use of cancer immunotherapy, a number of immune-related adverse events (irAEs) are being identified. These irAEs can be compared with known autoimmune disorders in similar tissues, with important similarities and differences. Understanding the etiology of irAEs may bring to light concepts applicable to immune responses in cancer, autoimmunity, and infectious disease. Read More

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http://www.jimmunol.org/lookup/doi/10.4049/jimmunol.1900264
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http://dx.doi.org/10.4049/jimmunol.1900264DOI Listing
April 2019
2 Reads

A systematic review and meta-analysis of infection risk with small molecule JAK inhibitors in rheumatoid arthritis.

Rheumatology (Oxford) 2019 Apr 14. Epub 2019 Apr 14.

Centre for Rheumatic Disease, Kings College London.

Objectives: To evaluate the risk of serious infection (SI) and herpes zoster (HZ) in rheumatoid arthritis patients receiving JAK inhibitors.

Methods: We conducted a systematic literature review and meta-analysis of phase II and III randomized controlled trials of tofacitinib (5 mg bid), baricitinib (4 mg od) and upadacitinib (15 mg od). Patient-exposure years were calculated. Read More

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http://dx.doi.org/10.1093/rheumatology/kez087DOI Listing
April 2019
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Forkhead box o3a suppresses lipopolysaccharide-stimulated proliferation and inflammation in fibroblast-like synoviocytes through regulating tripartite motif-containing protein 3.

J Cell Physiol 2019 Apr 13. Epub 2019 Apr 13.

Department of Rheumatology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, P. R. China.

Fibroblast-like synoviocytes (FLS), synovial tissue-specific cells, are key effector cells during the pathogenesis of rheumatoid arthritis (RA). Our previous study has shown that tripartite motif-containing protein 3 (TRIM3) overexpression inhibits the proliferation and cytokine secretion of RA FLS. Experiments with gene knockout mice have suggested the important roles of forkhead box o3a (Foxo3a) in RA pathogenesis. Read More

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http://dx.doi.org/10.1002/jcp.28615DOI Listing

Clinical characteristics of patients with polymicrobial septic arthritis.

Eur J Clin Microbiol Infect Dis 2019 Apr 13. Epub 2019 Apr 13.

Azrieli Faculty of Medicine, Bar-ilan University, Ramat Gan, Israel.

Little is known about the incidence, risk factors, clinical characteristics, and outcomes of patients with polymicrobial SA (PMSA). We aimed to determine the unique characteristics of patients with PMSA by comparing them to patients with monomicrobial SA (MMSA). We conducted a retrospective cohort study of patients 18 years and older admitted to a single tertiary care medical center, between 1998 and 2015, with surgically treated culture-positive SA affecting one or more joints. Read More

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http://dx.doi.org/10.1007/s10096-019-03557-4DOI Listing
April 2019
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Infections in arthroscopy.

Eur Rev Med Pharmacol Sci 2019 Apr;23(2 Suppl):279-287

UOC Ortopedia e Traumatologia, Dipartimento di Geriatria, Neuroscienze ed Ortopedia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

Infection is a rare complication of arthroscopic procedures, with an overall incidence estimated in less than 1%. However, the actual prevalence may be higher as many cases may go unreported. Despite low incidence, early diagnosis is of outmost importance in order to avoid devastating consequences, such as arthrofibrosis. Read More

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http://dx.doi.org/10.26355/eurrev_201904_17502DOI Listing

Managing of musculoskeletal infections in children.

Eur Rev Med Pharmacol Sci 2019 Apr;23(2 Suppl):179-186

Department of Orthopaedics and Traumatology, Institute of Scientific Research, Children's Hospital Bambino Gesù, Rome, Italy.

Objective: Epidemiological features of musculoskeletal infections are in continuous evolution. The incidence of emerging causative pathogen is arising. Nevertheless, up to 50% of osteoarticular infections shows negative cultures. Read More

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http://dx.doi.org/10.26355/eurrev_201904_17488DOI Listing
April 2019
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Acute osteomyelitis and septic arthritis in children: a systematic review of systematic reviews.

Eur Rev Med Pharmacol Sci 2019 Apr;23(2 Suppl):145-158

Orthopaedics and Traumatology, Polytechnic University of Marche, Ancona, Italy.

Objective: Septic arthritis and osteomyelitis are rare in children, but they are difficult to treat and are associated with a high rate of sequelae. This paper addresses the main clinical issues related to septic arthritis and osteomyelitis by means of a systematic review of systematic reviews.

Materials And Methods: The major electronic databases were searched for systematic reviews/meta-analyses septic arthritis and osteomyelitis. Read More

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http://dx.doi.org/10.26355/eurrev_201904_17484DOI Listing
April 2019
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Arthrodesis of the ankle joint in septic osteoarthritis: six years long term outcomes in authors' personal experience.

Eur Rev Med Pharmacol Sci 2019 Apr;23(2 Suppl):139-144

Department of Biomedical and Dental Sciences and Morphofunctional Imaging; School of Orthopaedics and Traumatology; University of Messina, Messina, Italy.

Objective: Our goal was to evaluate the long-term clinical outcome of ankle arthrodesis, obtained by an extramedullary internal fixation with or without bone-grafting in the treatment of ankle' septic arthritis.

Patients And Methods: All patients treated with arthrodesis by extramedullary internal fixation for septic arthritis of the ankle joint between January 2011 and December 2016 in the same hospital were included in our retrospective study. Patients were followed-up for a minimum of two years. Read More

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http://dx.doi.org/10.26355/eurrev_201904_17483DOI Listing
April 2019
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Post-arthroscopic septic arthritis of the knee. Analysis of the outcome after treatment in a case series and systematic literature review.

Eur Rev Med Pharmacol Sci 2019 Apr;23(2 Suppl):76-85

Department of Infectious Diseases, D. Cotugno Hospital, AORN Dei Colli, Naples, Italy.

Objective: The aim of this study was to review the characteristics of patients with septic arthritis after ACL reconstruction comparing our results with those deriving from the literature review.

Patients And Methods: Patients with suspected post arthroscopic septic arthritis of the knee occurring within 6 months after surgery were evaluated to be included in the investigation. Septic arthritis was defined by i) clinical evidence; ii) laboratory investigations; iii) synovial fluid leukocyte count of more than 2,5 x 104/μL or positive cultures obtained by synovial fluid aspirate. Read More

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http://dx.doi.org/10.26355/eurrev_201904_17477DOI Listing
April 2019
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Staged surgical management of the sequelae of neonatal septic hip arthritis: a case report and review of the literature.

Eur Rev Med Pharmacol Sci 2019 Apr;23(2 Suppl):6-11

Department of Orthopaedics and Paediatric Orthopaedics, and Department of Medical Informatics and Biostatistics; University of Medicine and Pharmacy, Cluj-Napoca, Romania.

Total necrosis of the femoral head is a common sequelae after septic hip arthritis in infancy. Septic hip dislocation may develop, with severe functional consequences on the growing child: limping and limb length discrepancy. We present our staged surgical treatment of Choi's type IV A sequelae of septic hip arthritis in a 2-year old boy. Read More

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http://www.europeanreview.org/article/17468
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http://dx.doi.org/10.26355/eurrev_201904_17468DOI Listing
April 2019
6 Reads

Clinical features and characteristics of uveitis associated with juvenile idiopathic arthritis in Japan: first report of the pediatric rheumatology association of Japan (PRAJ).

Pediatr Rheumatol Online J 2019 Apr 11;17(1):15. Epub 2019 Apr 11.

Department of Lifetime Clinical Immunology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.

Background: Although there are many reports on Juvenile Idiopathic arthritis-associated uveitis (JIA-U) from various countries, especially from Europe and North America, there are few reports from Asia. Our aim was to investigate the epidemiology, characteristics and predictors of JIA-U in Japan.

Methods: Data were retrospectively collected on 726 patients with JIA from medical records as of April 2016 at 15 medical centers specialized in pediatric rheumatic diseases. Read More

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http://dx.doi.org/10.1186/s12969-019-0318-5DOI Listing
April 2019
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Septic arthritis following femoral neck fracture: A case report.

Int J Surg Case Rep 2019 Apr 4;57:167-169. Epub 2019 Apr 4.

Department of Orthopedics, Faculty of Medicine, Prince of Songkla University, Songkhla, 90110, Thailand. Electronic address:

Introduction: Femoral neck fracture is common in the elderly, especially in the era of aging populations. Septic arthritis of the hip after femoral neck fracture is a rare complication. There are limited reports on this complication especially in patients without a severe medical condition and there is no consensus on the method of treatment of this complication. Read More

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http://dx.doi.org/10.1016/j.ijscr.2019.03.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460221PMC
April 2019
1 Read

Techniques for Continuous Irrigation of Septic Joints of the Hand.

Tech Hand Up Extrem Surg 2019 Apr 9. Epub 2019 Apr 9.

Department of Hand and Reconstructive Microsurgery, Singapore General Hospital, Singapore.

Septic arthritis of the small joints of the hand usually occurs secondary to bacterial inoculation through penetrating injury to the joint, or direct spread of infection from paronychia, felon, or pyogenic flexor tenosynovitis. Surgical treatment involves drainage and irrigation and may involve debridement if there is an open wound. We describe a method of continuous irrigation of septic joints of the hand postoperatively in the ward setting using an intravenous cannula placed within the joint and connected to an intravenous giving set with delivery of physiological fluid using a pump driver. Read More

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http://dx.doi.org/10.1097/BTH.0000000000000241DOI Listing
April 2019
2 Reads

[Update on the use of steroids in infectious diseases].

Rev Med Suisse 2019 Apr;15(646):792-796

Service des maladies infectieuses, HUG, 1211 Genève 14.

It is well established in daily clinical practice, on the basis of randomized studies, to add corticosteroïds to the antibiotherapy in cases of S. pneumoniae H. influenzae meningitis, tuberculous meningitis and Pneumocystis jiroveci pneumonia in HIV patients. Read More

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April 2019
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Predicting Periarticular Infection in Children With Septic Arthritis of the Hip: Regionally Derived Criteria May Not Apply to All Populations.

J Pediatr Orthop 2019 May/Jun;39(5):268-274

The Children's Hospital of Philadelphia, Philadelphia, PA.

Background: The management of septic arthritis of the hip in children can be complicated by the presence of additional coexisting periarticular infections (PAIs). Criteria predicting the presence of PAI have recently been proposed by Rosenfeld and colleagues with the goal of using magnetic resonance imaging (MRI) efficiently in the workup of septic arthritis. The purpose of this study was to determine the applicability of recently published predictive criteria for PAI (developed in the Southwestern United States using a variety of joints) to septic arthritis of the hip treated at a large Northeastern tertiary care center. Read More

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http://dx.doi.org/10.1097/BPO.0000000000000934DOI Listing
April 2019
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Discrepancies between self-reported tick bites and evidence of tick-borne disease exposure among nomadic Mongolian herders.

Zoonoses Public Health 2019 Apr 10. Epub 2019 Apr 10.

Division of Infectious Disease, Duke Global Health Institute, Duke University, Durham, North Carolina.

Twenty-six per cent of Mongolians live pastoral lifestyles, increasing their likelihood of exposure to ticks and placing them at a higher risk for contracting tick-borne diseases (TBDs). Anaplasma spp. and Rickettsia spp. Read More

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http://dx.doi.org/10.1111/zph.12579DOI Listing
April 2019
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Epithelial tissue cut-out following needle insertion into a joint: a potential complication during arthroscopy.

ANZ J Surg 2019 Apr 9. Epub 2019 Apr 9.

Bendigo Health, Bendigo, Victoria, Australia.

Background: Knee arthroscopy is a common orthopaedic procedure and often involves insertion of a needle through skin into a joint. This needle insertion can create epithelial tissue cut-outs possibly containing commensal bacteria that can be flushed into the joint, and potentially lead to post-arthroscopy septic arthritis. This study aims to assess the frequency of epithelial tissue cut-out creation on insertion of different needle sizes at different angles to the skin. Read More

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http://dx.doi.org/10.1111/ans.15131DOI Listing

Brief report: the disability of chronic chikungunya arthritis.

Clin Rheumatol 2019 Apr 8. Epub 2019 Apr 8.

Section of Rheumatology, Allergy and Clinical Immunology, Yale University School of Medicine, New Haven, CT, USA.

In 50% of patients, chikungunya fever (CHIKF) is followed by arthritic pain that is often chronic, painful, and disabling. To better define the spectrum of pain and disability in chronic CHIK arthritis (CCA), we evaluated 35 consecutive CCA patients seen in a Brazilian rheumatology clinic, using a pain Visual Analog Scale and the Health Assessment Questionnaire Disability Index. In our patients, pain and disability levels were of the same magnitude as are seen in other serious rheumatic diseases. Read More

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http://dx.doi.org/10.1007/s10067-019-04529-xDOI Listing
April 2019
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Use of an offset head center acetabular shell in difficult primary total hip arthroplasties.

Ann Transl Med 2019 Feb;7(4):75

Department of Orthopaedic Surgery, Cleveland Clinic, Cleveland, OH, USA.

Several conditions may predispose patients to development of antero-lateral acetabular bone deficiency, including developmental dysplasia of the hip, osteonecrosis, or septic arthritis, among others. This may compromise the ability to gain acetabular component stability and impair reliable fixation. Large acetabular shells have often been used to achieve adequate fixation in scenarios of severe bone loss, however, these techniques have been shown to elevate the center of rotation (COR) of the hip and alter hip biomechanics. Read More

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http://dx.doi.org/10.21037/atm.2018.09.11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409236PMC
February 2019
2 Reads

Bilateral Destructive Hip Disease from Untreated Juvenile Idiopathic Arthritis.

Case Rep Orthop 2019 6;2019:4593129. Epub 2019 Mar 6.

Department of Orthopaedic Surgery, University of California at Davis, 4860 Y Street, Suite 3800, Sacramento, CA 95829, USA.

We report a novel case of a pediatric patient with bilateral hip destruction from untreated Juvenile idiopathic arthritis (JIA). She was presented at the age of 9 with hip pain associated with bilateral acetabular dysplasia and a dislocated left femoral head. Only 1. Read More

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http://dx.doi.org/10.1155/2019/4593129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431357PMC
March 2019
1 Read

Microbiological Diagnosis of Skeletal System Infections in Children.

Authors:
Pablo Yagupsky

Curr Pediatr Rev 2019 Apr 8. Epub 2019 Apr 8.

Clinical Microbiology Laboratory, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva 84101. Israel.

Background: If not timely diagnosed and adequately treated, skeletal system infections in children may result in severe and permanent disability. Prompt identification of the etiology of the disease and determination of its antibiotic susceptibility is crucial for the successful management of septic arthritis, osteomyelitis, and spondylodiscitis. However, the bacteriological diagnosis of these infections has been traditionally limited by the low yield of conventional cultures and, on average, one-third of cases of pediatric joint and bone infections remained unconfirmed. Read More

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http://dx.doi.org/10.2174/1573396315666190408114653DOI Listing
April 2019
2 Reads

Sustained Delivery of Analgesic and Antimicrobial Agents to Knee Joint by Direct Injections of Electrosprayed Multipharmaceutical-Loaded Nano/Microparticles.

Polymers (Basel) 2018 Aug 9;10(8). Epub 2018 Aug 9.

Department of Orthopedic Surgery, Chang Gung Memorial Hospital-Linkou, Tao-Yuan 33305, Taiwan.

In this study, we developed biodegradable lidocaine⁻/vancomycin⁻/ceftazidime⁻eluting poly(d,l⁻lactide⁻⁻glycolide) (PLGA) nano/microparticulate carriers using an electrospraying process, and we evaluated the release behaviors of the carriers in knee joints. To prepare the particles, predetermined weight percentages of PLGA, vancomycin, ceftazidime, and lidocaine were dissolved in solvents. The PLGA/antibiotic/lidocaine solutions were then fed into a syringe for electrospraying. Read More

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http://dx.doi.org/10.3390/polym10080890DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403761PMC
August 2018
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Outcomes of paediatric septic arthritis of the hip and knee at 1-20 years in an Australian urban centre.

ANZ J Surg 2019 Apr 8. Epub 2019 Apr 8.

The Bone and Joint Institute, Royal Newcastle Centre, Newcastle, New South Wales, Australia.

Background: Septic arthritis in children is a joint threatening condition with potentially severe consequences; however, long-term outcome data is lacking. This study aims to determine 1-20-year outcomes following septic arthritis of hip and knee joints in children in an Australian population.

Methods: All paediatric patients with septic arthritis of the hip or knee from 1995 to 2015 treated at our Australian institution were retrospectively assessed. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/ans.15139
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http://dx.doi.org/10.1111/ans.15139DOI Listing
April 2019
3 Reads

How Streptococcus suis serotype 2 attempts to avoid attack by host immune defenses.

J Microbiol Immunol Infect 2019 Mar 27. Epub 2019 Mar 27.

College of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology, Xinxiang, China; Postdoctoral Research Base, Henan Institute of Science and Technology, Xinxiang, China. Electronic address:

Streptococcus suis (S. suis) type 2 (SS2) is an important zoonotic pathogen that causes swine streptococcosis, a widespread infectious disease that occurs in pig production areas worldwide and causes serious economic losses in the pork industry. Hosts recognize pathogen-associated molecular patterns (PAMPs) through pattern recognition receptors (PRRs) to activate both innate and acquired immune responses. Read More

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http://dx.doi.org/10.1016/j.jmii.2019.03.003DOI Listing
March 2019
3 Reads

Plasmacytoid dendritic cells respond to Epstein-Barr virus infection with a distinct type I interferon subtype profile.

Blood Adv 2019 Apr;3(7):1129-1144

Viral Immunobiology, Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland.

Infectious mononucleosis, caused by infection with the human gamma-herpesvirus Epstein-Barr virus (EBV), manifests with one of the strongest CD8 T-cell responses described in humans. The resulting T-cell memory response controls EBV infection asymptomatically in the vast majority of persistently infected individuals. Whether and how dendritic cells (DCs) contribute to the priming of this near-perfect immune control remains unclear. Read More

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http://dx.doi.org/10.1182/bloodadvances.2018025536DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457222PMC
April 2019
3 Reads

Remission Of Non-Infectious Anterior Scleritis: Incidence And Predictive Factors.

Am J Ophthalmol 2019 Apr 2. Epub 2019 Apr 2.

Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, MD; Department of Epidemiology, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD.

Purpose: To assess how often non-infectious anterior scleritis remits and identify predictive factors.

Methods: Our retrospective cohort study at four ocular inflammation subspecialty centers collected data for each affected eye/patient at every visit from center inception (1978, 1978, 1984, 2005) until 2010. Remission was defined as inactivity of disease off all suppressive medications at all visits spanning at least three consecutive months or at all visits up to the last visit (to avoid censoring patients stopping follow-up after remission). Read More

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http://dx.doi.org/10.1016/j.ajo.2019.03.024DOI Listing
April 2019
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Pediatric Septic Arthritis of the Knee: Predictors of Septic Hip Do Not Apply.

J Pediatr Orthop 2019 Apr 3. Epub 2019 Apr 3.

Washington University School of Medicine, Pediatric and Adolescent Orthopedic Surgery Washington University Orthopaedics, St. Louis, MO.

Background: The early diagnosis of pediatric septic arthritis is paramount to the prevention of long-term sequela. The purpose of this study is to investigate if the commonly used criteria developed by Kocher and colleagues for hip septic arthritis can be used for screening children with suspected septic knee.

Methods: We retrospectively reviewed the charts of patients under the age of 19, between June 2002 to June 2017, who presented to a major tertiary-care children's hospital with septic knee. Read More

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http://dx.doi.org/10.1097/BPO.0000000000001377DOI Listing

Invasive Meningococcal Disease: What We Should Know, Before It Comes Back.

Open Forum Infect Dis 2019 Mar 7;6(3):ofz059. Epub 2019 Feb 7.

Infectious Diseases Service and Microbiology Service, Institut d'Investigació Biomédica de Bellvitge-Hospital Universitari de Bellvitge, Universitat de Barcelona, L'Hospitalet de Llobregat, Spain.

Background: Invasive meningococcal disease (IMD), sepsis and/or meningitis continues to be a public health problem, with mortality rates ranging from 5% to 16%. The aim of our study was to further knowledge about IMD with a large series of cases occurring over a long period of time, in a cohort with a high percentage of adult patients.

Methods: Observational cohort study of patients with IMD between 1977 hand 2013 at our hospital, comparing patients with only sepsis and those with meningitis and several degrees of sepsis. Read More

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http://dx.doi.org/10.1093/ofid/ofz059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440684PMC
March 2019
2 Reads

Benefits and Adverse Events Associated with Extended Antibiotic Use in Total Knee Arthroplasty Periprosthetic Joint Infection.

Clin Infect Dis 2019 Apr 4. Epub 2019 Apr 4.

Arthritis and Arthroplasty Design Group, The Bone and Joint Center, Magee Womens Hospital of the University of Pittsburgh Medical Center; Department of Orthopaedic Surgery, Department of Bioengineering, and Clinical and Translational Science Institute, University of Pittsburgh; Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA.

Background: Total knee arthroplasty (TKA) periprosthetic joint infection (PJI) can be managed with debridement, antibiotic therapy, and implant retention (DAIR). Oral antibiotics can be used after DAIR for an extended time-period to improve outcomes. The objective of this study was to compare DAIR failure rates and adverse events between an initial course of intravenous antibiotic therapy and the addition of extended treatment with oral antibiotics. Read More

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http://dx.doi.org/10.1093/cid/ciz261DOI Listing
April 2019
2 Reads

Native Joint Septic Arthritis: Comparison of Outcomes with Medical and Surgical Management.

South Med J 2019 Apr;112(4):238-243

From the Department of Internal Medicine, Yale University School of Medicine, New Haven, and the Department of Medicine, Section of Infectious Diseases, Veterans Affairs Healthcare Systems of Connecticut, West Haven.

Objective: To determine whether there are differences in the outcomes of native joint septic arthritis (SA) in adults, based on medical versus surgical management.

Methods: A 10-year retrospective single-center study was conducted of patients admitted to a tertiary care hospital between January 1, 2006 and December 31, 2015 with a diagnosis of SA to compare outcomes based on the management approach taken: medical (bedside closed-needle joint aspiration) versus surgical (arthrotomy/arthroscopy). Evaluated outcomes included joint recovery, time to recovery, length of stay, disposition to home versus rehabilitation unit, recurrence of SA in the same joint, and mortality. Read More

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http://dx.doi.org/10.14423/SMJ.0000000000000958DOI Listing
April 2019
4 Reads

Epidemiology, management and outcomes of large and small native joint septic arthritis in adults.

Clin Infect Dis 2019 Apr 3. Epub 2019 Apr 3.

Middlemore Hospital, Auckland, New Zealand.

Background: Native joint septic arthritis (NJSA) is poorly studied. We describe the epidemiology, treatment and outcomes of large joint (LNJSA) and small joint NJSA (SNJSA) in adults at Middlemore Hospital, Auckland, New Zealand.

Methods: A coding-based retrospective study of patients ≥16 years old admitted between 2009 and 2014. Read More

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http://dx.doi.org/10.1093/cid/ciz265DOI Listing
April 2019
3 Reads

Anti-TNF Therapy in Spondyloarthritis and Related Diseases, Impact on the Immune System and Prediction of Treatment Responses.

Front Immunol 2019 19;10:382. Epub 2019 Mar 19.

Immunoregulation Unit, Department of Immunology, Institut Pasteur, Paris, France.

Immune-mediated inflammatory diseases (IMIDs), such as spondyloarthritis (SpA), psoriasis, Crohn's disease (CD), and rheumatoid arthritis (RA) remain challenging illnesses. They often strike at a young age and cause lifelong morbidity, representing a considerable burden for the affected individuals and society. Pioneering studies have revealed the presence of a TNF-dependent proinflammatory cytokine cascade in several IMIDs, and the introduction of anti-TNF therapy 20 years ago has proven effective to reduce inflammation and clinical symptoms in RA, SpA, and other IMID, providing unprecedented clinical benefits and a valid alternative in case of failure or intolerable adverse effects of conventional disease-modifying antirheumatic drugs (DMARDs, for RA) or non-steroidal anti-inflammatory drugs (NSAIDs, for SpA). Read More

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https://www.frontiersin.org/article/10.3389/fimmu.2019.00382
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http://dx.doi.org/10.3389/fimmu.2019.00382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434926PMC
March 2019
3 Reads

Clinical and Immunological Phenotype of Patients With Primary Immunodeficiency Due to Damaging Mutations in .

Front Immunol 2019 19;10:297. Epub 2019 Mar 19.

Faculty of Medicine, Center for Chronic Immunodeficiency (CCI), Medical Center, University of Freiburg, Freiburg, Germany.

Non-canonical NF-κB-pathway signaling is integral in immunoregulation. Heterozygous mutations in have recently been established as a molecular cause of common variable immunodeficiency (CVID) and DAVID-syndrome, a rare condition combining deficiency of anterior pituitary hormone with CVID. Here, we investigate 15 previously unreported patients with primary immunodeficiency (PID) from eleven unrelated families with heterozygous -mutations including eight patients with the common p. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00297DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435015PMC
March 2019
13 Reads

Clinical features and human T-cell leukemia virus type-1 (HTLV-1) proviral load in HTLV-1-positive patients with rheumatoid arthritis: Baseline data in a single center cohort study.

Mod Rheumatol 2019 Apr 2:1-23. Epub 2019 Apr 2.

a Rheumatic and Collagen Disease Center, Sasebo Chuo Hospital , Sasebo , Japan.

Objective: Recently, Human T-cell leukemia virus type-1 proviral load (HTLV-1 PVL) has been evaluated as an important predictor of adult T-cell leukemia/lymphoma (ATL) in HTLV-1 carriers. We aimed to evaluate whether HTLV-1 PVL is also important for the development of ATL among HTLV-1-positive patients with rheumatoid arthritis (RA).

Methods: We established a cohort of 82 HTLV-1-positive RA patients between 2017 - 2018. Read More

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http://dx.doi.org/10.1080/14397595.2019.1602931DOI Listing
April 2019
4 Reads

X-linked agammaglobulinemia (XLA):Phenotype, diagnosis, and therapeutic challenges around the world.

World Allergy Organ J 2019 22;12(3):100018. Epub 2019 Mar 22.

Division of Allergy Immunology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.

Background: X-linked agammaglobulinemia is an inherited immunodeficiency recognized since 1952. In spite of seven decades of experience, there is still a limited understanding of regional differences in presentation and complications. This study was designed by the Primary Immunodeficiencies Committee of the World Allergy Organization to better understand regional needs, challenges and unique patient features. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S19394551193010
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http://dx.doi.org/10.1016/j.waojou.2019.100018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439403PMC
March 2019
3 Reads

Second Case of HOIP Deficiency Expands Clinical Features and Defines Inflammatory Transcriptome Regulated by LUBAC.

Front Immunol 2019 18;10:479. Epub 2019 Mar 18.

Inflammatory Disease Section, National Human Genome Research Institute (NHGRI), NIH, Bethesda, MD, United States.

HOIP is the catalytic subunit of the linear ubiquitination chain assembly complex (LUBAC) that is essential for NF-κB signaling and thus proper innate and adaptive immunity. To date only one patient with HOIP deficiency has been reported with clinical characteristics that include autoinflammation, immunodeficiency, amylopectinosis, and systemic lymphangiectasia. We sought to identify a genetic cause of a disease for an 8 year-old girl who presented with early-onset immune deficiency and autoinflammation. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00479DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431612PMC
March 2019
3 Reads

When acute kidney injury in the intensive care unit is not acute tubular necrosis: A case report of κ-light chain crystalline tubulopathy
.

Clin Nephrol 2019 May;91(5):311-316

Introduction: This case highlights the importance of getting a thorough workup for acute kidney injury before assigning a diagnosis.

Case Presentation: A 68-year-old male was referred to our clinic after a recent outside hospitalization for septic knee arthritis and acute kidney injury requiring hemodialysis. He had chronic kidney disease presumed secondary to diabetes with baseline GFR 50 mL/min. Read More

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http://dx.doi.org/10.5414/CN109693DOI Listing
May 2019
3 Reads

[Clinical Pharmaceutical Research Based on New Proteome Analysis Based on Chromatographic Separation].

Authors:
Kaname Ohyama

Yakugaku Zasshi 2019 ;139(4):505-509

Graduate School of Biomedical Sciences, Nagasaki University.

Comprehensive identification of antigens in immune complexes (IC-antigens) is beneficial to provide insights into pathophysiology and could form the basis for novel diagnostic and treatment strategies for many immune-related diseases. Immune complexome analysis is a method for comprehensively identifying and profiling IC-antigens in biological fluids (such as serum and cerebrospinal fluid). We applied this strategy to the analysis of circulating ICs in autoimmune diseases (rheumatoid arthritis, Sjögren's syndrome, systemic scleroderma, and systemic lupus erythematosus), infectious diseases, and cancers. Read More

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https://www.jstage.jst.go.jp/article/yakushi/139/4/139_18-00
Publisher Site
http://dx.doi.org/10.1248/yakushi.18-00167DOI Listing
April 2019
6 Reads