20,921 results match your criteria Septic Arthritis


Innate Immune Modulation by GM-CSF and IL-3 in Health and Disease.

Int J Mol Sci 2019 Feb 15;20(4). Epub 2019 Feb 15.

Department of Translational Medical Sciences and Center for Basic and Clinical Immunology Research (CISI), University of Naples Federico II, 80131 Naples, Italy.

Granulocyte-macrophage colony-stimulating factor (GM-CSF) and inteleukin-3 (IL-3) have long been known as mediators of emergency myelopoiesis, but recent evidence has highlighted their critical role in modulating innate immune effector functions in mice and humans. This new wealth of knowledge has uncovered novel aspects of the pathogenesis of a range of disorders, including infectious, neoplastic, autoimmune, allergic and cardiovascular diseases. Consequently, GM-CSF and IL-3 are now being investigated as therapeutic targets for some of these disorders, and some phase I/II clinical trials are already showing promising results. Read More

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http://dx.doi.org/10.3390/ijms20040834DOI Listing
February 2019

IL33/ST2 Axis in Diabetic Kidney Disease: A Literature Review.

Medicina (Kaunas) 2019 Feb 14;55(2). Epub 2019 Feb 14.

School and Operative Unit of Allergy and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Messina, Via Consolare Valeria, 98125 Messina, Italy.

Interleukin-33 (IL-33) is a cytokine belonging to the IL-1 family, playing a role in inflammatory, infectious and autoimmune diseases and expressed in the cellular nucleus in several tissues. High levels of IL-33 are expressed in epithelial barrier tissues and endothelial barriers. ST2 is a receptor for IL-33, expressed selectively on a subset of Th2 cells, mediating some of their functions. Read More

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http://dx.doi.org/10.3390/medicina55020050DOI Listing
February 2019

Neutrophil-derived lactoferrin induces the inflammatory responses of rheumatoid arthritis synovial fibroblasts via Toll-like receptor 4.

Clin Exp Rheumatol 2019 Feb 11. Epub 2019 Feb 11.

Department of Rheumatology, Infectious Diseases, and Laboratory Medicine, Faculty of Medicine, University of Miyazaki, Japan.

Objectives: Damage-associated molecular patterns (DAMPs) are proposed to drive aberrant stimulation of Toll-like receptors (TLRs) in rheumatoid arthritis (RA) inflamed joints. In the current study we investigated the role of the neutrophil-derived lactoferrin (LTF), as an endogenous ligand for TLR4 in the inflammatory response of RA synovial fibroblasts (RASFs).

Methods: RASFs were stimulated with LTF, and the expressions of inflammatory cytokines in RASFs were measured. Read More

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February 2019

Predictive value of ex-vivo drug-inhibited cytokine production for clinical response to biologic DMARD therapy in rheumatoid arthritis.

Clin Exp Rheumatol 2019 Feb 7. Epub 2019 Feb 7.

Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands.

Objectives: To investigate ex-vivo drug-inhibited cytokine production before the start of a biological DMARD (bDMARD) as predictor of treatment response in rheumatoid arthritis (RA).

Methods: In a prospective RA cohort study [BIO-TOP], blood samples were obtained from patients before the start of a bDMARD (abatacept, adalimumab, etanercept, rituximab or tocilizumab). Peripheral blood mononuclear cells were pre-incubated for 1 hour with the therapeutic in-vivo concentration of the bDMARD and stimulated for 24 hours with heat-killed Candida albicans or Pam3Cys. Read More

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February 2019

Calm in the midst of cytokine storm: a collaborative approach to the diagnosis and treatment of hemophagocytic lymphohistiocytosis and macrophage activation syndrome.

Pediatr Rheumatol Online J 2019 Feb 14;17(1). Epub 2019 Feb 14.

Division of Immunolgy, Boston Children's Hospital, Boston, MA, USA.

Background: Hemophagocytic lymphohistiocytosis (HLH) and macrophage activation syndrome (MAS) were historically thought to be distinct entities, often managed in isolation. In fact, these conditions are closely related. A collaborative approach, which incorporates expertise from subspecialties that previously treated HLH/MAS independently, is needed. Read More

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http://dx.doi.org/10.1186/s12969-019-0309-6DOI Listing
February 2019

Relative risk of tuberculosis in patients with rheumatic diseases managed with anti-tumour necrosis factor-alpha therapy: A nationwide cohort study.

J Clin Pharm Ther 2019 Feb 14. Epub 2019 Feb 14.

Turkish Medicines and Medical Devices Agency, Ministry of Health, Ankara, Turkey.

What Is Known And Objective: Anti-tumour necrosis factor-alpha (anti-TNF-α) therapy is known to raise the risk of granulomatous infections, leading to development of risk management strategies at national or global level. This study aimed to determine the relative risk (RR) of tuberculosis (TB) due to anti-TNF-α usage in patients with rheumatologic diseases (RDs) in a nationwide basis.

Method: This retrospective cohort study included patients with rheumatoid arthritis (RA), ankylosing spondylitis, juvenile idiopathic arthritis or psoriatic arthritis (PsA) that treated with or without anti-TNF-α agents, as registered in the national prescription information system between years 2013 and 2015. Read More

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http://dx.doi.org/10.1111/jcpt.12814DOI Listing
February 2019

The Incidence of Pin Tract Infections and Septic Arthritis in Percutaneous Distal Femur Pinning.

J Pediatr Orthop 2019 Feb 11. Epub 2019 Feb 11.

Children's Orthopaedic Center, Children's Hospital Los Angeles, Los Angeles, CA.

Background: Retrograde percutaneous pinning often involves intra-articular pin placement. Classic teaching has cautioned about the risk of septic arthritis with intra-articular pins, although an incidence has not been reported for this complication. The purpose of this study was to determine the incidence of pin tract infections and septic arthritis following retrograde percutaneous pinning of the distal femur. Read More

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http://dx.doi.org/10.1097/BPO.0000000000001346DOI Listing
February 2019
2 Reads

Effects of Antibiotics on α-Toxin Levels during Staphylococcus aureus Culture: Implications for the Protection of Chondrocytes in a Model of Septic Arthritis.

Cartilage 2019 Feb 14:1947603519828433. Epub 2019 Feb 14.

1 Centre for Integrative Physiology, Deanery of Biomedical Sciences, University of Edinburgh, Edinburgh, Scotland, UK.

Objective: Septic arthritis results from joint infection by Staphylococcus aureus, which produces potent α-toxin causing cell death, potentially leading to permanent cartilage damage. Treatment is by joint irrigation and antibiotics, although it is unclear if, following treatment with antibiotics which cause bacterial lysis, there is release of additional stored α-toxin.

Design: A rabbit erythrocyte hemolysis assay was optimised to assess biologically-active α-toxin from cultured S. Read More

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http://dx.doi.org/10.1177/1947603519828433DOI Listing
February 2019

The Timing of Corticosteroid Injections After Arthroscopic Shoulder Procedures Affects Postoperative Infection Risk.

Am J Sports Med 2019 Feb 13:363546518825348. Epub 2019 Feb 13.

Department of Orthopaedic Surgery, University of Virginia, Charlottesville, Virginia, USA.

Background:: Corticosteroid injections are sometimes used in the postoperative period after shoulder arthroscopy; however, a well-defined safety profile has not been established.

Purpose:: To examine the association between the timing of postoperative corticosteroid injections and rates of infection after shoulder arthroscopy.

Study Design:: Cohort study; Level of evidence, 3. Read More

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http://dx.doi.org/10.1177/0363546518825348DOI Listing
February 2019

Seronegative Bilateral Symmetrical Inflammatory Polyarthritis: Think Twice Before Starting Immunosuppression.

Eur J Case Rep Intern Med 2018 28;5(8):000895. Epub 2018 Aug 28.

Department of Medicine (Rheumatology), Hamad Medical Corporation, Doha, Qatar.

The most common cause of bilateral symmetrical polyarthritis in the small joints is rheumatoid arthritis. However, if seronegative arthritis is involved, it could be the case that other underlying causes need to be diagnosed. This is particularly important for those coming from or living in developing countries where infectious causes should always be considered. Read More

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http://dx.doi.org/10.12890/2018_000895DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346836PMC

Tuberculous Arthritis of the Ankle.

Eur J Case Rep Intern Med 2018 26;5(6):000870. Epub 2018 Jun 26.

Department of Internal and Emergency Medicine, Catholic University of the Sacred Heart School of Medicine, Rome, Italy.

Tuberculosis (TB) is an infectious disease caused by the s complex (MTBC). Pulmonary TB is the most common form of presentation, but extrapulmonary tuberculosis (EPTB) contributes significantly to morbidity and mortality. Rarely, patients with EPTB develop a form of ankle or foot arthritis. Read More

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http://dx.doi.org/10.12890/2018_000870DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346884PMC

Native Joint Septic Arthritis due to Clostridium tarantellae.

Anaerobe 2019 Feb 9. Epub 2019 Feb 9.

Laboratory of Microbiology, Department of Infectious Agents, Saint Louis - Lariboisiere - Fernand Widal University Hospital, APHP, Paris, France; IAME, UMR 1137, INSERM, Paris Diderot University, Sorbonne Paris Cité, Paris, France.

Clostridium is a diverse genus including more than 200 species involved in varied clinical presentations in infectious diseases. Septic arthritis caused by Clostridium sp. are however uncommon. Read More

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http://dx.doi.org/10.1016/j.anaerobe.2019.02.004DOI Listing
February 2019
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IFN-γ-dependent nitric oxide suppresses Brucella-induced arthritis by inhibition of inflammasome activation.

J Leukoc Biol 2019 Feb 12. Epub 2019 Feb 12.

Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Missouri, Columbia, Missouri, USA.

Brucellosis, caused by the intracellular bacterial pathogen Brucella, is a globally important zoonotic disease for which arthritis is the most common focal complication in humans. Wild-type mice infected systemically with Brucella typically do not exhibit arthritis, but mice lacking IFN-γ develop arthritis regardless of the route of Brucella infection. Here, we investigated mechanisms by which IFN-γ suppresses Brucella-induced arthritis. Read More

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http://dx.doi.org/10.1002/JLB.4MIA1018-409RDOI Listing
February 2019

Inhibition of IL-1β signaling by anakinra shows a critical role for bone loss in experimental arthritogenic alphavirus infections.

Arthritis Rheumatol 2019 Feb 12. Epub 2019 Feb 12.

Institute for Glycomics, Griffith University, Gold Coast Campus, QLD, Australia.

Objective: Arthritogenic alphaviruses, such as Ross River virus (RRV), chikungunya virus (CHIKV), Sindbis virus (SINV), Barmah Forest virus, o'nyong-nyong virus and Mayaro virus cause sporadic and sometimes large outbreaks worldwide. These viruses particularly affect joints of the extremities and can lead to debilitating and potentially chronic polyarthritis/polyarthralgia. The host's innate immune response plays a crucial role in inducing pro-inflammatory host factors, leading to tissue destruction and bone loss in the joints. Read More

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http://doi.wiley.com/10.1002/art.40856
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http://dx.doi.org/10.1002/art.40856DOI Listing
February 2019
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Extensive transmission of microbes along the gastrointestinal tract.

Elife 2019 Feb 12;8. Epub 2019 Feb 12.

Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.

The gastrointestinal tract is abundantly colonized by microbes, yet the translocation of oral species to the intestine is considered a rare aberrant event, and a hallmark of disease. By studying salivary and fecal microbial strain populations of 310 species in 470 individuals from five countries, we found that transmission to, and subsequent colonization of, the large intestine by oral microbes is common and extensive among healthy individuals. We found evidence for a vast majority of oral species to be transferable, with increased levels of transmission in colorectal cancer and rheumatoid arthritis patients and, more generally, for species described as opportunistic pathogens. Read More

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http://dx.doi.org/10.7554/eLife.42693DOI Listing
February 2019

Combined Blockade of TNF-α and IL-17A Alleviates Progression of Collagen-Induced Arthritis without Causing Serious Infections in Mice.

J Immunol 2019 Feb 11. Epub 2019 Feb 11.

Immunology Discovery, Janssen Research and Development, LLC, Spring House, PA 19477;

The cytokines TNF-α and IL-17A are elevated in a variety of autoimmune diseases, including rheumatoid arthritis. Both cytokines are targets of several biologic drugs used in the clinic, but unfortunately many patients are refractory to these therapies. IL-17A and TNF-α are known to mediate signaling synergistically to drive expression of inflammatory genes. Read More

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http://dx.doi.org/10.4049/jimmunol.1801436DOI Listing
February 2019
1 Read

Timing of Abatacept Before Elective Arthroplasty and Risk of Post-operative Outcomes.

Arthritis Care Res (Hoboken) 2019 Feb 11. Epub 2019 Feb 11.

University of Alabama at Birmingham, Division of Clinical Immunology and Rheumatology.

Objectives: Guidelines recommend holding biologic therapies before hip and knee arthroplasty, yet evidence to inform optimal timing is limited. We aimed to determine whether holding abatacept infusions is associated with lower risk of adverse post-operative outcomes.

Methods: This retrospective cohort study using U. Read More

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http://doi.wiley.com/10.1002/acr.23843
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http://dx.doi.org/10.1002/acr.23843DOI Listing
February 2019
3 Reads

Psoas Abscess with Septic Arthritis of the Hip in a Patient with Chronic Back Pain.

Am J Med Case Rep 2018 10;6(11):224-225. Epub 2018 Dec 10.

Department of Internal Medicine, State University of New York, Downstate Medical Center, Brooklyn, New York, United States-11203.

Psoas abscess is a rare clinical entity that requires early diagnosis and timely intervention to avoid serious complications of the disease. We report a case of psoas abscess that presented initially as low back pain then complicated with septic arthritis. We discuss the clinical diagnosis, intervention and follow up of the case along with review of the literature. Read More

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http://dx.doi.org/10.12691/ajmcr-6-11-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368174PMC
December 2018
1 Read

Effect of circadian rhythm, age, training, and acute lameness on serum concentrations of cartilage oligomeric matrix protein (COMP) neo-epitope in horses.

Equine Vet J 2019 Feb 10. Epub 2019 Feb 10.

Division of Pathology, Pharmacology and Toxicology, Department of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences, Uppsala, Sweden.

Background: Molecular serum markers that can identify early reversible osteoarthritis (OA) in horses are lacking.

Objectives: We studied serum concentrations of a novel cartilage oligomeric matrix protein (COMP) neo-epitope in horses subjected to short-term exercise and with acute lameness. The effects of circadian rhythm and age were also evaluated. Read More

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http://dx.doi.org/10.1111/evj.13082DOI Listing
February 2019
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Inflammatory arthritis and Mycobacterium Tuberculosis infection: a diagnostic and management challenge for Knee arthroplasty in endemic areas.

J Pak Med Assoc 2019 02;69(Suppl 1)(1):S101-S107

Department of Surgery, Section of Orthopaedics, The Aga Khan University, Karachi Pakistan.

Tuberculosis continues to be one of the most challenging health problems more prevalent in developing countries. Pakistan ranks 5th in tuberculosis prevalence among the high-burden countries. Prosthetic joint infection of the knee by acid fast bacilli is a rare and distressing complication, occurring in nearly 1% of primary joint arthroplasties requiring prolonged medical treatment and multiple surgeries. Read More

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February 2019
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Chronic hepatitis B viral infection among RA patients-a cross-sectional control study.

Clin Rheumatol 2019 Feb 8. Epub 2019 Feb 8.

Department of Medicine 'B', Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, 52621, Tel-Hashomer, Israel.

Background And Objectives: Rheumatoid arthritis (RA) is the most common inflammatory joint disorder presenting also with extra-articular manifestations. As many other autoimmune diseases, it has been suggested that infectious diseases might contribute to its emergence. Hepatitis viruses were suggested by several reports as a trigger of RA onset. Read More

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http://link.springer.com/10.1007/s10067-019-04448-x
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http://dx.doi.org/10.1007/s10067-019-04448-xDOI Listing
February 2019
4 Reads

Pyogenic sacroiliitis in children: don't forget the very young.

Eur J Pediatr 2019 Feb 7. Epub 2019 Feb 7.

Department of Pediatrics, Mount Scopus Hadassah-Hebrew University Medical Center, 91120, Jerusalem, Israel.

Pyogenic sacroiliitis (PS) is rare with less than 100 pediatric cases reported in the medical literature. To better characterize PS in the pediatric population, we investigated a series of children presenting with PS. Retrospective data analysis was done at an academic tertiary center between the years of 2000 and 2017. Read More

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http://dx.doi.org/10.1007/s00431-019-03333-8DOI Listing
February 2019
2 Reads

Increased Staphylococcus aureus Nasal Carriage Rates in Rheumatoid Arthritis Patients on Biologic Therapy.

J Arthroplasty 2019 Jan 17. Epub 2019 Jan 17.

Department of Medicine, Hospital for Special Surgery, Weill-Cornell Medical School, New York, NY.

Background: Rheumatoid arthritis patients are at increased risk for periprosthetic joint infection after arthroplasty. The reason is multifactorial. Nasal colonization with Staphylococcus aureus is a modifiable risk factor; carriage rates in RA patients are unknown. Read More

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http://dx.doi.org/10.1016/j.arth.2019.01.025DOI Listing
January 2019
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A case report of severe recurrent varicella in an ankylosing spondylitis patient treated with adalimumab - a new side effect after 15 years of usage.

BMC Infect Dis 2019 Feb 7;19(1):127. Epub 2019 Feb 7.

University Hospital for Infectious Diseases "Dr. Fran Mihaljević", Mirogojska 8, 10000, Zagreb, Croatia.

Background: Tumor necrosis factor-α (TNF-α) antagonists, most of which are monoclonal antibodies, became a widespread treatment for autoimmune diseases such as rheumatoid arthritis, ankylosing spondylitis, inflammatory bowel diseases, psoriasis, psoriatic arthritis, hidradenitis suppurativa and uveitis. Their use is based on the blockage of TNF-α, which plays an important role in granulomas formation, development of phagosomes, activation and differentiation of macrophages, immune response against viral pathogens. The multiple adverse effects of TNF-α inhibition have been identified, including a two-to four-fold increased risk of active tuberculosis and other granulomatous conditions and an increased occurrence of some other serious bacterial, fungal and certain viral infections. Read More

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https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
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http://dx.doi.org/10.1186/s12879-019-3768-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367735PMC
February 2019
2 Reads

Outcomes among 196 patients with non-infectious proximal aortitis.

Arthritis Rheumatol 2019 Feb 7. Epub 2019 Feb 7.

Division of Rheumatic and Immunologic Diseases, Center for Vasculitis Care and Research, Cleveland Clinic Foundation, Cleveland, Ohio, USA.

Objective: Non-infectious aortitis may occur in the context of a recognized systemic disease or as a topographically-limited lesion without systemic features, termed clinically-isolated aortitis (CIA). From a large population of patients in a single center dedicated to aortic diseases, we have sought to better define and stress the limitations of this diagnostic category, and suggest recommendations for care.

Methods: Records of patients undergoing thoracic aortic surgery (1996-2012) at the Cleveland Clinic were reviewed to identify 196 with histopathology-proven aortitis. Read More

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http://dx.doi.org/10.1002/art.40855DOI Listing
February 2019
3 Reads

Knee Arthritis in Children: When Can It Be Safely Treated With Needle Joint Aspiration? A Large Children's Tertiary Hospital Study.

J Pediatr Orthop 2019 Mar;39(3):130-135

Department of Paediatric Orthopaedic Surgery, Maternal and Child Hospital, Sant Joan de Déu of Barcelona.

Background: Early joint decompression associated to antibiotic therapy is the most important procedure to reduce joint damage in septic knee arthritis in children. Several joint decompression methods have been described such as arthrotomy with open debriding, arthroscopic drainage or needle joint aspiration. The aim of the present study was to determinate which patients with acute septic knee arthritis could be safely treated with needle joint aspiration. Read More

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http://dx.doi.org/10.1097/BPO.0000000000000883DOI Listing
March 2019
1 Read

New-onset non-infectious pulmonary manifestations among patients with systemic lupus erythematosus in Sweden.

Arthritis Res Ther 2019 Feb 6;21(1):48. Epub 2019 Feb 6.

Division of Clinical Epidemiology, Department of Medicine Solna, Karolinska Institutet, Stanford School of Medicine, Stockholm, Sweden.

Objective: The objective was to estimate the incidence of lung disease among patients with systemic lupus erythematosus (SLE).

Methods: Using Swedish register data, we identified patients with SLE and pulmonary diagnoses from the National Patient Register through ICD codes. We matched patients with SLE with individuals from the general population. Read More

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http://dx.doi.org/10.1186/s13075-018-1804-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366020PMC
February 2019
1 Read

Romidepsin suppresses monosodium urate crystal-induced cytokine production through upregulation of suppressor of cytokine signaling 1 expression.

Arthritis Res Ther 2019 Feb 6;21(1):50. Epub 2019 Feb 6.

Department of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.

Background: Acute gouty arthritis currently is the most common form of inflammatory arthritis in developed countries. Treatment is still suboptimal. Dosage of urate-lowering therapy is often too low to reach target urate levels, and adherence to therapy is poor. Read More

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http://dx.doi.org/10.1186/s13075-019-1834-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366029PMC
February 2019
1 Read

Microbiome dysbiosis is associated with disease duration and increased inflammatory gene expression in systemic sclerosis skin.

Arthritis Res Ther 2019 Feb 6;21(1):49. Epub 2019 Feb 6.

Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.

Background: Infectious agents have long been postulated to be disease triggers for systemic sclerosis (SSc), but a definitive link has not been found. Metagenomic analyses of high-throughput data allows for the unbiased identification of potential microbiome pathogens in skin biopsies of SSc patients and allows insight into the relationship with host gene expression.

Methods: We examined skin biopsies from a diverse cohort of 23 SSc patients (including lesional forearm and non-lesional back samples) by RNA-seq. Read More

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http://dx.doi.org/10.1186/s13075-019-1816-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366065PMC
February 2019
1 Read
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Dengue and Zika Virus Cross-Reactive Human Monoclonal Antibodies Protect against Spondweni Virus Infection and Pathogenesis in Mice.

Cell Rep 2019 Feb;26(6):1585-1597.e4

Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA; Department of Pathology & Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA; Department of Molecular Microbiology, Washington University School of Medicine, Saint Louis, MO 63110, USA; The Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, Saint Louis, MO 63110, USA. Electronic address:

Spondweni virus (SPOV) is the flavivirus that is most closely related to Zika virus (ZIKV). Although SPOV causes sporadic human infections in Africa, recently it was found in Culex mosquitoes in Haiti. To investigate the pathogenic spectrum of SPOV, we developed infection models in mice. Read More

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http://dx.doi.org/10.1016/j.celrep.2019.01.052DOI Listing
February 2019
2 Reads

[Septic arthritis of the knee by Staphylococcus warneri].

Acta Ortop Mex 2018 Sep-Oct;32(5):287-290

Servicio de Cirugía Ortopédica y Traumatología, Unidad de Sépticos. Hospital Universitario «Germans Trias i Pujol». Barcelona, España.

Septic arthritis usually occurs as an acute joint process that can cause a rapid destruction of the cartilage, if the necessary therapeutic measures were not taken. Rarely, Staphylococcus warneri may be the cause of this pathology although due to its diagnostic difficulty we can make mistakes in its treatment. We present the case of a patient with septic arthritis of the knee by this germ and we intend to remark what are the diagnostic measures and recommendations to consider for this osteoarticular infection. Read More

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February 2019

Survival Rate on a 10-Year Follow-Up of Total Wrist Replacement Implants: A 23-Patient Case Series.

J Wrist Surg 2019 Feb 7;8(1):24-29. Epub 2018 Aug 7.

Department of Hand Surgery, SOS main, CCOM, University Hospital of Strasbourg, FMTS, University of Strasbourg, Illkirch, France.

 According to current literature, the estimated average survival rate for Remotion, the total wrist implants, is above 90% on an 8-year follow-up. We examined our series of Remotion to calculate its survival rate on a 10-year follow-up.  A total of 23 cases of total wrist implants were reviewed. Read More

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http://dx.doi.org/10.1055/s-0038-1668152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358454PMC
February 2019
2 Reads

Feline bartonellosis key issues and possible vectors

Ann Parasitol 2018 ;64(4):309-315

Department of Epizootiology and Clinic of Infectious Diseases, Faculty of Veterinary Medicine, University of Life Sciences, ul. Głęboka 30, 20-612 Lublin, Poland

Bartonellosis is a disease caused by Bartonella spp. microorganisms which belong to the Rickettsiales order. This disease is a zoonosis, B. Read More

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January 2018
2 Reads

[Rare erosive arthritis and dermatitis syndrome in Whipple's disease].

Z Rheumatol 2019 Feb 4. Epub 2019 Feb 4.

Rheumatologie, Immunologie, Nephrologie, AK Altona, Paul-Ehrlich-Str. 1, 22763, Hamburg, Deutschland.

Whipple's disease is a rare infectious disease, which can affect various organ systems. Arthritis is a common symptom and therefore the infection is often misdiagnosed as seronegative rheumatoid arthritis. In rare cases an infection with Tropheryma whipplei can also cause skin lesions, such as subcutaneous nodules, erythema nodosum or vasculitis. Read More

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http://dx.doi.org/10.1007/s00393-019-0602-2DOI Listing
February 2019
3 Reads

Unmet need in rheumatology: reports from the Targeted Therapies meeting 2018.

Ann Rheum Dis 2019 Feb 2. Epub 2019 Feb 2.

Swedish Medical Center, University of Washington, Seattle, Washington, USA.

To develop a comprehensive listing of the greatest unmet scientific and clinical needs in rheumatology. The 20th annual international Targeted Therapies meeting brought more than 100 leading basic scientists and clinical researchers in rheumatology, immunology, epidemiology, molecular biology and other specialties. During the meeting, breakout sessions were convened, consisting of five disease-specific groups with 20-30 experts assigned to each group based on expertise. Read More

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http://dx.doi.org/10.1136/annrheumdis-2018-214280DOI Listing
February 2019
5 Reads

Moraxella nonliquefaciens septic arthritis in a hematopoietic stem cell transplant patient a case report and review of the literature.

J Infect Public Health 2019 Jan 30. Epub 2019 Jan 30.

Division of Infectious Diseases, Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon. Electronic address:

Background: Septic arthritis is a common rheumatologic condition with myriad microbiological causative agents. Moraxella is one of the very rare causes of septic arthritis. We hereby present the third case of Moraxella nonliquefaciens septic arthritis and the first case in a hematopoietic stem cell transplant patient (HSCT) along with a brief review of the literature. Read More

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http://dx.doi.org/10.1016/j.jiph.2019.01.059DOI Listing
January 2019
1 Read

Can C-Reactive Protein Be Used to Predict Acute Septic Arthritis in the Adult Population?

South Med J 2019 Feb;112(2):108-111

From Arrowe Park Hospital, Wirral, and Hull York Medical School, York, United Kingdom.

Objectives: The objective of this study was to establish whether C-reactive protein (CRP) could be used to predict native joint septic arthritis (SA) in the adult population.

Methods: All patients who underwent native joint aspiration in accident and emergency settings between April 2012 and September 2016 were identified from laboratory microbiology records. Patients were divided into three groups for analysis: patients with SA, patients with crystal arthropathy, and patients with normal or osteo/inflammatory arthritic joints. Read More

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http://dx.doi.org/10.14423/SMJ.0000000000000927DOI Listing
February 2019
1 Read

Prolonged time between intravenous contrast administration and image acquisition results in increased synovial thickness at magnetic resonance imaging in patients with juvenile idiopathic arthritis.

Pediatr Radiol 2019 Feb 1. Epub 2019 Feb 1.

Department of Radiology and Nuclear Medicine, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105, AZ, Amsterdam, The Netherlands.

Background: Post-contrast synovial thickness measurement is necessary for scoring disease activity in juvenile idiopathic arthritis (JIA). However, the timing of post-contrast sequences varies widely among institutions. This variation in timing could influence thickness measurements. Read More

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http://dx.doi.org/10.1007/s00247-018-04332-xDOI Listing
February 2019
1 Read

The role of real-time PCR testing in the investigation of paediatric patients with community-onset osteomyelitis and septic arthritis.

Ir J Med Sci 2019 Jan 31. Epub 2019 Jan 31.

Irish Meningitis and Sepsis Reference Laboratory, Temple Street Children's University Hospital, Dublin 1, Ireland.

Background: Culture yield in osteomyelitis and septic arthritis is low, emphasising the role for molecular techniques.

Aims: The purpose of this study was to review the laboratory investigation of childhood osteomyelitis and septic arthritis.

Methods: A retrospective review was undertaken in an acute tertiary referral paediatric hospital from January 2010 to December 2016. Read More

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http://link.springer.com/10.1007/s11845-019-01973-1
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http://dx.doi.org/10.1007/s11845-019-01973-1DOI Listing
January 2019
3 Reads

Septic Arthritis Following Radiofrequency Ablation of the Genicular Nerves.

Pain Med 2019 Jan 28. Epub 2019 Jan 28.

Department of Anesthesiology, Westchester Medical Center, New York Medical College, Valhalla, NY.

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http://dx.doi.org/10.1093/pm/pny308DOI Listing
January 2019

Immune's-boosting agent: Immunomodulation potentials of propolis.

J Family Community Med 2019 Jan-Apr;26(1):57-60

Department of Physiology, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.

With a concomitant increase in immune-related diseases such as allergic diseases, Type 1 diabetes mellitus, rheumatoid arthritis, multiple sclerosis, psoriasis, inflammatory bowel disease and other immune-related responses such as immunodeficiency, various infectious, diseases, vaccines, and malignancies, it has become very important to have a well-balanced and properly functioning immune system for the maintenance of human health. Recent scientific research has strongly suggested propolis as one of the most promising immunomodulation agents. This review describes recent findings with respect to propolis and its ingredients that show potential in this respect and evaluate their potential mechanisms. Read More

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http://dx.doi.org/10.4103/jfcm.JFCM_46_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335834PMC
January 2019
3 Reads

Inflammatory arthritis and Mycobacterium Tuberculosis infection: a diagnostic and management challenge for Knee arthroplasty in endemic areas.

J Pak Med Assoc 2019 Feb;69(Suppl 1)(1):S101-S107

Infectious Disease, Department of medicine, The Aga Khan University, Karachi Pakistan.

Tuberculosis continues to be one of the most challenging health problems more prevalent in developing countries. Pakistan ranks 5th in tuberculosis prevalence among the high-burden countries. Prosthetic joint infection of the knee by acid fast bacilli is a rare and distressing complication, occurring in nearly 1% of primary joint arthroplasties requiring prolonged medical treatment and multiple surgeries. Read More

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February 2019
6 Reads

Diagnostic response to a cross-border challenge for the Swiss caprine arthritis encephalitis virus eradication program.

Schweiz Arch Tierheilkd 2019 Feb;161(2):93-104

Institute of Virology and Immunology, Bern & Mittelhäusern, Switzerland.

Introduction: Animal trading between countries with different small ruminant lentivirus infectious status is a potential danger for the reintroduction of eradicated genotypes. This was the case in 2017 with the importation of a large flock of seropositive goats into Switzerland. The handling of this case permitted us to test the preventive measures in place. Read More

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http://dx.doi.org/10.17236/sat00196DOI Listing
February 2019
1 Read

An Unusual Presentation of Hip Pain in a Patient with Known Hyper-IgE Syndrome and Multiple Calcified Pelvic Apophyses.

J Orthop Case Rep 2018 Jul-Aug;8(4):89-92

Department of Trauma and Orthopaedics, Heart of England NHS Trust, UK.

Introduction: Hyper-IgE syndrome (HIES) is a relatively rare condition which, from childhood, renders patients susceptible to infection. Typically patients with HIES can develop various orthopaedic manifestations of this disease, namely scoliosis, pathological fractures, osteoporosis, and potentially septic arthritis.

Case Report: We present the case of WJ, a 44-year old patient with known HIES(since the age of 11) and a 7-week history of left hip pain. Read More

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http://dx.doi.org/10.13107/jocr.2250-0685.1176DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343551PMC
January 2019
1 Read

Pelvic Osteomyelitis in a Child - A Diagnostic Dilemma.

J Orthop Case Rep 2018 Jul-Aug;8(4):86-88

Department of Orthopaedics, Guy's Hospital, London, United Kingdom.

Introduction: Pelvic osteomyelitis presents a diagnostic challenge due to its rarity and non-specific presentation. Early advance imaging in the form of magnetic resonance imaging (MRI) is warranted if clinical suspicion is high. We present an unusual case of pubic rami osteomyelitis, presenting with clinical findings of septic arthritis treated appropriately with early imaging and intravenous antibiotics with satisfactory outcome. Read More

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http://dx.doi.org/10.13107/jocr.2250-0685.1174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343553PMC
January 2019
1 Read

Can a Septic Hip Decision Rule Aid in the Evaluation of Suspected Pediatric Musculoskeletal Infections?

J Emerg Med 2019 Jan 21. Epub 2019 Jan 21.

Children's Mercy Hospital, Kansas City, Missouri.

Background: Musculoskeletal (MSK) infections can be difficult to diagnose in acute care settings. The utility of clinical decision tools for pediatric MSK infections in an emergency department has not been well studied.

Objective: Our aim was to evaluate the performance of a septic hip clinical decision rule (CDR) in the evaluation of pediatric musculoskeletal infections. Read More

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http://dx.doi.org/10.1016/j.jemermed.2018.12.022DOI Listing
January 2019
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Use of standard diagnostic techniques to determine eradication of infection in experimental equine septic arthritis.

Can J Vet Res 2019 Jan;83(1):24-33

Department of Veterinary Pathology (Koziy, Dickinson, Rybicka, Moshynskyy, Simko), Department of Large Animal Clinical Sciences (Yoshimura, Bracamonte), and Prairie Diagnostic Services Inc. (Ngeleka), Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4.

Septic arthritis is an important disease in horses, necessitating aggressive and prolonged therapy. In order to guide therapy, reliable methods of detecting the eradication of infection are needed. Therefore, the objective of this study was to investigate detection of eradication of infection in an experimental model of equine septic arthritis using standard diagnostic techniques. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318826PMC
January 2019

Is staged management with immediate conversion of external fixation to retrograde intramedullary nailing for combat-related Gustilo Type III supracondylar femur fractures safe and reliable method?

Injury 2019 Jan 14. Epub 2019 Jan 14.

Orthopaedia and Traumatology Department, Gulhane Training and Research Hospital, Ankara, Turkey. Electronic address:

Introduction: Femur fractures due to bomb explosions and gunshots in battlefield require osseous stabilization as quickly as possible to expedite emergent conditions. İmmediate external fixation is the initial procedure as usual with planned early conversion to definitive treatment. The purpose of the current study is to determine the results of the early retrograde intramedullary nailing in combat-related injuries. Read More

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http://dx.doi.org/10.1016/j.injury.2019.01.019DOI Listing
January 2019
1 Read

Tumor Necrosis Factor and Regulatory T Cells.

Yonsei Med J 2019 Feb;60(2):126-131

Laboratory of Immunology and Infectious Diseases, Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Korea.

CD4⁺CD25⁺FoxP3⁺ regulatory T (Treg) cells play major roles in the maintenance of immune homeostasis. In this review, we comprehensively describe the relationship between tumor necrosis factor (TNF) and Treg cells, focusing on the effects of TNF on Treg cells and on TNF-producing Treg cells. Contradictory results have been reported for the effect of TNF on the suppressive activity of Treg cells. Read More

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https://synapse.koreamed.org/DOIx.php?id=10.3349/ymj.2019.60
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http://dx.doi.org/10.3349/ymj.2019.60.2.126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342721PMC
February 2019
4 Reads