60,752 results match your criteria Septic Arthritis


Direct Effect of Septic Plasma in Human Cell Lines Viability.

Blood Purif 2018 Dec 6:1-7. Epub 2018 Dec 6.

Department of Nephrology, Dialysis and Transplant, San Bortolo Hospital, Vicenza, Italy.

Background: Sepsis is a life-threatening condition often associated with a high incidence of multiple organs injury. Several papers suggested the immune response by itself, with the production of humoral inflammatory mediators, is crucial in determining organ injury. However, little is known of how sepsis directly induces organ injury at the cellular levels. Read More

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December 2018
1 Read

Urine Catecholamines in Children with Severe Enterovirus A71 infection: Comparison with Paediatric Septic Shock.

Biomarkers 2018 Dec 6:1-15. Epub 2018 Dec 6.

a Children's Medical Center , Taichung Veterans General Hospital , Taichung , Taiwan.

Purpose: Hypercatecholaminemia-related heart failure has been proposed as the main cause of enterovirus A71-related (EV-A71) early mortality. The purpose of this study was to measure urine catecholamine concentrations in severe EV-A71-infected children.

Methods: A total of 35 children, aged 2. Read More

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December 2018

Septic Arthritis of the Hip-Risk Factors Associated With Secondary Surgery.

J Am Acad Orthop Surg 2018 Dec 4. Epub 2018 Dec 4.

From the Department of Orthopaedics (Dr. R. F. Murphy, Dr. Plumblee, Dr. Barfield, and Dr. Dow), Medical University of South Carolina, Charleston SC, Children's Orthopaedics of Atlanta, Atlanta, GA (Dr. J. S. Murphy, Mr. Fuerstenau), the Department of Orthopaedics and Biomedical Engineering, University of Tennessee-Campbell Clinic, Memphis, TN (Dr. Spence and Dr. Kelly), and Shriner's Hospital for Children, Springfield, MA (Dr. Mooney).

Introduction: Septic arthritis of the hip (SAH) is a common condition encountered by pediatric orthopaedic surgeons and is treated with arthrotomy and irrigation. Depending on the response to initial treatment, some patients require surgical treatment beyond the index procedure. The purpose of this study was to investigate risk factors for repeat surgical intervention after initial arthrotomy for presumed SAH. Read More

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December 2018
2 Reads

Apixaban-Associated Spontaneous Splenic Rupture-A Case Report.

Ir Med J 2018 08 13;111(7):792. Epub 2018 Aug 13.

University Hospital Galway, Ireland

Introduction A 62-year-old lady presented to The Emergency Department (ED) with one-day history of dizziness, vomiting and feeling weak. ECG showed new onset Atrial Fibrillation. Four days ago, she was referred to the Cardiology team where she underwent PCI and was discharged on Apixaban and Plavix. Read More

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Impact of Intravenous Fluid Challenge Infusion Time on Macrocirculation and Endothelial Glycocalyx in Surgical and Critically Ill Patients.

Biomed Res Int 2018 1;2018:8925345. Epub 2018 Nov 1.

Dpt. of Anesthesiology and Intensive Care Medicine, Faculty of Medicine in Plzen, Charles University, Plzen, Czech Republic.

The fluid challenge (FC) is a well-established test of preload reserve. Only limited data exist in regard to the FC efficacy based on infusion time. Slow administration may be associated with lack of effect based on fluid redistribution and external conditions changes. Read More

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November 2018

Prolonged length of stay in the emergency department and increased risk of hospital mortality in patients with sepsis requiring ICU admission.

Emerg Med J 2018 Dec 5. Epub 2018 Dec 5.

Department of Internal Medicine, Mercer University School of Medicine, Macon, Georgia, USA.

Background And Objectives: Delayed patient admission to the intensive care unit (ICU) from the ED is common in China. Patients with severe sepsis or septic shock requiring ICU admission are in need of specialised monitoring and tailored treatment. Delayed admission to the ICU might be associated with adverse clinical outcomes for patients with sepsis. Read More

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December 2018
1.776 Impact Factor

Masquelet technique to treat a septic nonunion after nailing of a femoral open fracture.

Injury 2018 Nov 22. Epub 2018 Nov 22.

Orthopaedics and Trauma Unit, Emergency Department, Ospedale Policlinico San Martino, Largo R. Benzi 10-16132, Genoa, Italy.

Septic nonunion is one of the most serious complications after an open fracture because both the infection and the bone defect need to be dealt with. Treatment is always protracted and expensive, and the result is uncertain. In the 1980s, Masquelet first described the technique of the induced membrane and autologous bone grafting to manage critical bone defects. Read More

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November 2018
3 Reads

Modified Masquelet's technique with nail and allograft: A case report.

Injury 2018 Nov 28. Epub 2018 Nov 28.

Department of Traumatology, IRCCS Humanitas Research Hospital, Milano, Italy.

The large bone defect treatment is a challenge issue in modern orthopaedic trauma surgery. One of the most used technique is the Masquelet's technique. In this case report we used a modified Masquelet technique to fill a six centimeters bone gap in the proximal femur. Read More

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November 2018
3 Reads

Lipoxin A4 receptor agonist BML-111 induces autophagy in alveolar macrophages and protects from acute lung injury by activating MAPK signaling.

Respir Res 2018 Dec 5;19(1):243. Epub 2018 Dec 5.

Emergency and Intensive Care Center, The Third Xiangya Hospital of Central South University, 138 Tongzipo Road, Changsha, 410013, Hunan Province, PR, China.

Background: Acute lung injury (ALI) is a life-threatening lung disease where alveolar macrophages (AMs) play a central role both in the early phase to initiate inflammatory responses and in the late phase to promote tissue repair. In this study, we examined whether BML-111, a lipoxin A4 receptor agonist, could alter the phenotypes of AM and thus present prophylactic benefits for ALI.

Methods: In vitro, isolated AMs were treated with lipopolysaccharide (LPS) to induce ALI. Read More

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December 2018

Targeting protein translation to prevent septic kidney injury.

Authors:
Sarah C Huen

J Clin Invest 2018 Dec 3. Epub 2018 Dec 3.

The development of acute kidney injury (AKI) in patients with sepsis causes significant morbidity and mortality. The pathogenesis of AKI in sepsis is incompletely understood. In this issue of the JCI, Hato et al. Read More

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December 2018

Duration of Exposure to Antipseudomonal β-Lactam Antibiotics in the Critically Ill and Development of New Resistance.

Pharmacotherapy 2018 Dec 3. Epub 2018 Dec 3.

Department of Pharmacy Practice, St. Louis College of Pharmacy, St. Louis, MO, USA.

Study Objective: Minimizing the duration of broad-spectrum antimicrobial exposure in the critically ill is a commonly used strategy aimed at preventing resistance. Our objective was to correlate the duration of exposure to antipseudomonal β-lactam antibiotics with the development of new resistance in critically ill patients.

Design: Single-center, retrospective cohort study. Read More

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December 2018

Intestinal microbiota mediates the susceptibility to polymicrobial sepsis-induced liver injury by granisetron generation in mice.

Hepatology 2018 Dec 1. Epub 2018 Dec 1.

Department of Intensive Care Unit, Zhujiang Hospital, Southern Medical University, Guangzhou, China.

Sepsis-induced liver injury is recognized as a key problem in intensive care units (ICUs). The gut microbiota has been touted as an important mediator of liver disease development; however, the precise roles of gut microbiota in regulating sepsis-induced liver injury are unknown. Here, we aimed to investigate the role of the gut microbiota in sepsis-induced liver injury and the underlying mechanism. Read More

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December 2018
11.055 Impact Factor

Catecholamine Vasopressor Support Sparing Strategies in Vasodilatory Shock.

Pharmacotherapy 2018 Dec 1. Epub 2018 Dec 1.

Department of Pharmacy Practice, University of Pittsburgh School of Pharmacy, Pittsburgh, PA.

Shock syndromes are associated with unacceptably high rates of mortality in critically ill patients despite advances in therapeutic options. Vasodilatory shock is the most common type encountered in the intensive care unit. It is manifested by cardiovascular failure, peripheral vasodilatation, and arterial hypotension leading to tissue hypoperfusion and organ failure. Read More

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December 2018

Female mice exhibit less renal mitochondrial injury but greater mortality using a comorbid model of experimental sepsis.

Intern Med Rev (Wash D C) 2018 Oct;4(10)

Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR 72205.

Given the inherent heterogeneity of the septic patient population and possible comorbid conditions, it is not surprising that the influence of gender on incidence and outcomes are still unclear. The goal of this study was to use a clinically relevant murine model of sepsis, cecal ligation and puncture (CLP) in CD1 mice, with and without uniphrectomy as a comorbid condition to investigate possible gender differences in renal mitochondrial function and dynamics. High resolution respirometry on fresh kidney biopsies was used to measure renal respiratory complex activities. Read More

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October 2018

Elastic stable chest repair and its hybrid variants in 86 patients with pectus excavatum.

J Thorac Dis 2018 Oct;10(10):5736-5746

Department of Pediatric Surgery, University Hospital Erlangen, Erlangen, Germany.

Background: Complex and mature funnel chest deformities are traditionally managed with open surgical procedures. Elastic stable chest repair (ESCR) has been used successfully and safely for relapse corrections. Does pure plate osteosynthesis in ESCR allow comparable corrective potency and implant safety as hybrid methods with metal bars?

Methods: Data from 86 patients with open funnel chest correction between 2011 and 2015 were analyzed in this retrospective study. Read More

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October 2018
1 Read

Circulating histone H3 levels are increased in septic mice in a neutrophil-dependent manner: preclinical evaluation of a novel sandwich ELISA for histone H3.

J Intensive Care 2018 26;6:79. Epub 2018 Nov 26.

1Department of Systems Biology in Thromboregulation, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.

Background: Nuclear histone proteins are released into the extracellular space during sepsis and act as major mediators of death. However, circulating histone levels have not been precisely quantified.

Methods: We developed a novel enzyme-linked immunosorbent assay (ELISA) for detection of circulating histone H3 levels and evaluated its performance. Read More

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November 2018

Is early goal-directed therapy associated with a higher risk of adverse events?

J Intensive Care 2018 26;6:78. Epub 2018 Nov 26.

Intensive Care Unit, Okba Ben Nafee Hospital, 45 street, el-Asafra, Alexandria, 21539 Egypt.

The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 suggested against the use of the early goal-directed therapy (EGDT) in patients with septic shock. This recommendation was based on the three large-scale trials (ProCESS, ARISE, and ProMISe). Although the three trials showed no difference in mortality between EGDT and usual care, the guidelines determined that the potential harms presented by EGDT likely outweigh its potential benefits. Read More

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November 2018
2 Reads

[Intra-abdominal infections. Update and recommendations].

Medicina (B Aires) 2018 ;78(6):417-426

Hospital Prof. Alejandro Posadas, El Palomar, Buenos Aires, Argentina.

Intra-abdominal infections represent a group of intra and retroperitoneal processes, ranging from localized infections to complicated ones, sepsis and septic shock, associated with a significant mortality rate. They are the third most commonly identified cause of sepsis and the second cause of death in the intensive care unit. Although antimicrobial therapy must be started as soon as possible, especially in critically ill patients, the source control procedure is highly relevant. Read More

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January 2018

Long-term results after open repair of inflammatory infrarenal aortic aneurysms.

J Vasc Surg 2018 Jun 28. Epub 2018 Jun 28.

Department of Vascular and Endovascular Surgery, University Hospital Heidelberg, Heidelberg, Germany.

Objective: The objective of this study was to investigate the long-term outcome after open repair of inflammatory infrarenal aortic aneurysms.

Methods: A total of 62 patients (mean age, 68.9 ± 8. Read More

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June 2018
1 Read

Inter-rater Agreement for Abstraction of the Early Management Bundle, Severe Sepsis/Septic Shock (SEP-1) Quality Measure in a Multi-Hospital Health System.

Jt Comm J Qual Patient Saf 2018 Nov 29. Epub 2018 Nov 29.

is Staff Physician and Quality Officer, Medical ICU, Respiratory Institute, Cleveland Clinic.

Background: The Early Management Bundle, Severe Sepsis/Septic Shock (SEP-1) quality measure is complex to abstract, which may lead to discrepancies between abstractors. This study was designed to evaluate inter-rater agreement between abstractors at individual hospitals in a health system and a lead abstractor on abstraction elements and measure compliance for SEP-1.

Methods: Patient cases qualifying for abstraction for SEP-1 over a four-month period in 2016 were initially abstracted at a local hospital and then centrally by a lead abstractor. Read More

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November 2018

The toll of complicated endocarditis and septic sequela: Old wives' tales and dogma.

J Thorac Cardiovasc Surg 2018 Nov 3. Epub 2018 Nov 3.

Department of Surgery, University of Kentucky, Lexington, Ky. Electronic address:

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November 2018

Impact of an Acinetobacter baumannii outbreak on kidney events in a burn unit: A targeted machine learning analysis.

Am J Infect Control 2018 Nov 29. Epub 2018 Nov 29.

AP-HP, GH St-Louis-Lariboisière, Department of Anesthesiology and Critical Care and Burn Unit, Paris, France; Université Paris Diderot, Paris, France; UMR INSERM 942, Institut National de la Santé et de la Recherche Médicale (INSERM), Paris, France; F-CRIN, INICRCT Network, Paris, France.. Electronic address:

Background: Multidrug-resistant (MDR) bacteria outbreaks represent a major threat in intensive care units. Patients may then be exposed to drug-related direct toxicity during such outbreaks. The objective of this study was to explore the impact of an outbreak of imipenem-resistant Acinetobacter baumannii (IR-AB) on renal outcomes. Read More

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November 2018
1 Read

Sodium tanshinone IIA sulfonate attenuates cardiac dysfunction and improves survival of rats with cecal ligation and puncture-induced sepsis.

Chin J Nat Med 2018 Nov;16(11):846-855

State Key Laboratory of Pharmaceutical Biotechnology, Medical School, Nanjing University, Nanjing 210093, China. Electronic address:

Cardiac dysfunction, a common consequence of sepsis, is the major contribution to morbidity and mortality in patients. Sodium tanshinone IIA sulfonate (STS) is a water-soluble derivative of Tanshinone IIA (TA), a main active component of Salvia miltiorrhiza Bunge, which has been widely used in China for the treatment of cardiovascular and cerebral system diseases. In the present study, the effect of STS on sepsis-induced cardiac dysfunction was investigated and its effect on survival rate of rats with sepsis was also evaluated. Read More

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November 2018

Factors associated with mortality in severe community-acquired pneumonia: A multicenter cohort study.

J Crit Care 2018 Nov 22;50:82-86. Epub 2018 Nov 22.

Programa de Pós-Graduação em Clínica Médica, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.; Postgraduate Program, Instituto D'Or de Pesquisa e Ensino, Rio de Janeiro, Brazil.

Objective: Describe characteristics and outcomes of CAP admitted to public ICUs in Brazil.

Methods: Retrospective cohort study in 4 Tertiary Public Hospitals in Rio de Janeiro, Brazil during 2016. Patients admitted to ICUs with a diagnosis of community-acquired pneumonia were included. Read More

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November 2018

Quantitative Measure of Intestinal Permeability Using Blue Food Coloring.

J Surg Res 2019 Jan 27;233:20-25. Epub 2018 Jul 27.

Dumont-UCLA Transplant Center, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California. Electronic address:

Background: Loss of intestinal barrier integrity plays a fundamental role in the pathogenesis of various gastrointestinal diseases and is implicated in the onset of sepsis and multiple organ failure. An array of methods to assess different aspects of intestinal barrier function suffers from lack of sensitivity, prolonged periods of specimen collection, or high expense. We have developed a technique to measure the concentration of the food dye FD&C Blue #1 from blood and sought to assess its utility in measuring intestinal barrier function in humans. Read More

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January 2019

Right ventricle in severe sepsis and septic shock.

J Crit Care 2018 Nov 23. Epub 2018 Nov 23.

Muğla University, Faculty of Medicine, Department of Cardiology, Turkey.

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November 2018

RV/LV ratio in severe sepsis and septic shock: Response to Letter to the Editor.

J Crit Care 2018 Nov 22. Epub 2018 Nov 22.

Division of Cardiovascular Medicine, Department of Medicine, University of Utah, Salt Lake City, UT, United States.

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November 2018

Evaluation of sepsis induced cardiac dysfunction as a predictor of mortality.

Cardiovasc Ultrasound 2018 Nov 30;16(1):31. Epub 2018 Nov 30.

MICU, St John's Medical College, Kormangala, Bangalore, 560034, India.

Background: Sepsis is characterized by life threatening organ dysfunction with dysregulated immune response. Cardiac dysfunction seen in sepsis is unique as it is reversible within 7-10 days. Initial study by Parker et al. Read More

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November 2018

[Multicenter investigation of extracorporeal membrane oxygenation application in pediatric intensive care unit in China].

Zhonghua Er Ke Za Zhi 2018 Dec;56(12):929-932

Department of Pediatric Emergency Medicine, Children's Hospital of Fudan University, Shanghai 201102, China.

To survey the conduction and evaluate the effectiveness of extracorporeal membrane oxygenation (ECMO) therapy in pediatric intensive care unit (PICU) in China mainland. In a questionnaire-based survey, we retrospectively reviewed the application of ECMO in children's hospital and general hospital in China mainland to summarize and analyze the categories of diseases and prognosis of children treated with ECMO therapy. By December 31, 2017, a total of 23 hospitals using ECMO, including 22 tertiary referral hospitals and 1 secondary hospital, among which 16 were children's hospitals and 7 were general hospitals. Read More

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December 2018
3 Reads

[A multicenter clinical study on 1 138 cases of invasive pneumococcal disease in children from 2012 to 2017].

Zhonghua Er Ke Za Zhi 2018 Dec;56(12):915-922

Zunyi Medical University, Zunyi 563003, China.

To explore the clinical features, the serotype distribution and drug resistance of the isolates in patient with invasive pneumococcal disease (IPD). By retrieving the laboratory information system in 18 children's hospitals from 2012 to 2017, the children with IPD were enrolled. (Spn) must be isolated from the sterile sites (blood, cerebrospinal fluid, hydrothorax and joint effusion etc. Read More

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December 2018
4 Reads

Impact of Electronic Physician Order-Set on Antibiotic Ordering Time in Septic Patients in the Emergency Department.

Appl Clin Inform 2018 Oct 5;9(4):869-874. Epub 2018 Dec 5.

UPMC St. Margaret, Pittsburgh, Pennsylvania, United States.

Background:  Sepsis is a serious medical condition that can lead to organ dysfunction and death. Research shows that each hour delay in antibiotic administration increases mortality. The Surviving Sepsis Campaign Bundles created standards to assist in the timely treatment of patients with suspected sepsis to improve outcomes and reduce mortality. Read More

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October 2018
1 Read

Management of Sepsis in Patients with Cirrhosis: current evidence and practical approach.

Hepatology 2018 Dec 5. Epub 2018 Dec 5.

Division of Gastroenterology and Hepatology.

Sepsis in patients with cirrhosis is associated with high mortality. An impaired immune response accounts for the increased infection risk observed in these patients. Hemodynamic and systemic changes suggestive of sepsis may be seen in patients with cirrhosis in the absence of infection, therefore diagnosis and treatment of sepsis may be delayed. Read More

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December 2018

Klotho deficiency aggravates sepsis-related multiple organ dysfunction.

Am J Physiol Renal Physiol 2018 Dec 5. Epub 2018 Dec 5.

Internal Medicine - Nephrology, University of Sao Paulo School of Medicine, Brazil.

Sepsis-induced organ failure is characterized by a massive inflammatory response and oxidative stress. Acute kidney injury (AKI) occurs in approximately half of patients in septic shock, and the mortality associated with sepsis-induced AKI is unacceptably high. Klotho is a protein expressed by renal cells and has anti-senescence properties. Read More

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December 2018

Melatonin and cortisol exhibit different circadian rhythm profiles during septic shock depending on timing of onset: a prospective observational study.

Ann Intensive Care 2018 Dec 4;8(1):118. Epub 2018 Dec 4.

Intensive Care Unit, Alexandroupolis University Hospital, Democritus University of Thrace, 68100, Dragana, Alexandroupolis, Greece.

Background: Septic shock has been found to disrupt circadian rhythms. Moreover, timing of onset has been associated with different circadian profiles in experimental studies.

Results: In this prospective study, we enrolled 26 patients divided into two groups: Group A (N = 15) included subjects who had septic shock at the time of ICU admission and Group B (N = 11) included patients who developed septic shock during ICU admission. Read More

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December 2018

[Prognostic value of difference between peripheral venous and arterial partial pressure of carbon dioxide in patients with septic shock: a pilot study].

Nan Fang Yi Ke Da Xue Xue Bao 2018 Nov;38(11):1312-1317

Department of Critical Care Medicine, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, China.

Objective: To evaluate the prognostic value of the difference between peripheral venous and arterial partial pressure of carbon dioxide in patients with septic shock following early resuscitation.

Methods: This prospective study was conducted among the patients with septic shock treated in our department during the period from May, 2017 to May, 2018. Peripheral venous, peripheral arterial and central venous blood samples were collected simultaneously and analyzed immediately at bedside after 6-h bundle treatment. Read More

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November 2018

Unsolved issues in the treatment of spontaneous peritonitis in patients with cirrhosis: nosocomial versus community-acquired infections and the role of fungi.

Rev Recent Clin Trials 2018 Dec 3. Epub 2018 Dec 3.

Department of Clinical Medicine and Surgery, Section of Infectious Diseases, University of Naples Federico II, 80131, Naples. Italy.

Introduction: Historically, spontaneous bacterial peritonitis (SBP) has represented one of the most frequent and relevant infectious complications of advanced liver disease, and this is still valid today. Nevertheless, in recent years the role of fungi as causative pathogens of primary peritonitis in patients with cirrhosis has become not negligible. Another issue is linked with the traditional distinction, instrumental in therapeutic choice, between community-acquired and nosocomial forms, according to the onset. Read More

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December 2018

Pilloin, A Flavonoid Isolated from , Exhibits Anti-Inflammatory Activity In Vitro and In Vivo.

Molecules 2018 Dec 2;23(12). Epub 2018 Dec 2.

Institute of Traditional Medicine, National Yang-Ming University, Taipei 11221, Taiwan.

Flavonoids, widely present in medicinal plants and fruits, are known to exhibit multiple pharmacological activities. In this study, we isolated a flavonoid compound, pilloin, from and investigated its anti-inflammatory activity in bacterial lipopolysaccharide-induced RAW 264.7 macrophages and septic mice. Read More

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December 2018

Douleurs proctologiques aiguës. Une urgence à éliminer, la suppuration anale.

Rev Prat 2017 Feb;66(2):148-151

Service de proctologie, maison de santé protestante, Talence, France.

Anal acute pain. Anal pain is a symptom commonly reported during consultation for ano-rectal disease. It is a nonspecific symptom, associated with both emergency and chronic pathologies, and with both benign and serious conditions. Read More

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February 2017

Spondylodiscites infectieuses : à suspecter devant toute rachialgie inflammatoire.

Rev Prat 2016 Oct;66(8):893-898

Service de médecine interne et maladies infectieuses, CHRU de Tours. Université François Rabelais - Faculté de médecine de Tours-Centre de référence de prise en charge des infections ostéo-articulaires du Grand-Ouest (CRIOGO).

Vertebral osteomyelitis: to suspect ahead any inflammatory spinal pain. Infectious vertebral osteomyelitis is a rare and severe condition with potential septic, neurologic or mechanical complications and a lethality of about 10%. Clinical diagnosis is difficult and delay in management is frequent. Read More

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October 2016
2 Reads

Leptospirose.

Rev Prat 2016 Oct;66(8):886-892

Maladies infectieuses et tropicales, groupe hospitalier La Pitié-Salpêtrière, Paris, France.

Leptospirosis. Leptospirosis is the first worldwide anthropozoonosis with an incidence of 1 000 000 cases per year. It is more frequently encountered in tropical areas but also can be diagnosed in tempered places. Read More

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October 2016
1 Read

Infections ostéo-articulaires de l’adulte.

Rev Prat 2016 Nov;66(9):993-1000

Service des maladies infectieuses, centre de référence inter-régional pour la prise en charge des infections ostéo-articulaires complexes (CRIOAc) des Hospices civils de Lyon ; université Claude-Bernard Lyon 1 ; centre international de recherche en infectiologie, Inserm U1111, CNRS UMR5308, ENS de Lyon, Lyon, France.

Bone and joint infection in adults. Bone and joint infections include highly heterogeneous clinical entities, ranging from acute native septic arthritis to complex chronic orthopedic device- related infection. Their management requires a multidisciplinary approach. Read More

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November 2016
1 Read

[Finger necrosis following arterial cannulation - a case report].

Laeknabladid 2018 Dec;104(12):551-553

Department of Surgery, Faculty of Medicine, Faculty of Nursing, University of Iceland.

Arterial cannulation is a common procedure in critically ill patients, as it facilitates continuous monitoring of blood pressure, titration of inotropes, vasopressors and fluids and is also used for blood sampling. Serious complications from arterial lines are very rare, permanent ischemic damage occurs in less than 0,1% of patients. We report the case of a 60-year-old woman in septic shock caused by a perforated duodenal ulcer which was treated with emergent laparoscopic repair. Read More

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December 2018
1 Read

[S2k guidelines of the PEG on calculated parenteral initial treatment of bacterial diseases in adults : Focussed summary and supplementary information on antibiotic treatment of critically ill patients].

Anaesthesist 2018 Dec 3. Epub 2018 Dec 3.

Stabsstelle Klinische Mikrobiologie und Krankenhaushygiene, Klinikum der Universität München, Campus Großhadern, München, Deutschland.

In January 2018 the recent revision of the S2k guidelines on calculated parenteral initial treatment of bacterial diseases in adults-update 2018 (Editor: Paul Ehrlich Society for Chemotherapy, PEG) was realized. It is a helpful tool for the complex infectious disease setting in an intensive care unit. The present summary of the guidelines focuses on the topics of anti-infective agents, including new substances, pharmacokinetics and pharmacodynamics as well as on microbiology, resistance development and recommendations for calculated drug therapy in septic patients. Read More

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December 2018
2 Reads

Sepsis Induces a Long-Lasting State of Trained Immunity in Bone Marrow Monocytes.

Front Immunol 2018 19;9:2685. Epub 2018 Nov 19.

Department of Anesthesiology, Heidelberg University Hospital, Heidelberg, Germany.

Innate immune memory describes the functional reprogramming of innate immune cells after pathogen contact, leading to either a boosted (trained immunity) or a diminished (immune tolerance) response to a secondary stimulus. Immune tolerance or "sepsis-induced immunosuppression" is a typical hallmark of patients after sepsis survival, characterized by hypo-responsiveness of the host's immune system. This condition renders the host vulnerable for a persisting infection or the occurrence of secondary, often opportunistic infections, along with an increased mortality rate. Read More

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November 2018
1 Read

Infective endocarditis complicated with nonobstructive ST elevation myocardial infarction related to septic embolism with intracranial hemorrhage: A case report.

Medicine (Baltimore) 2018 Nov;97(48):e13089

Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University Hospital.

Rationale: Infective endocarditis (IE) complicated with obstructive ST elevation myocardial infarction (STEMI) has been reported in the literature and which were mostly related to coronary artery embolism, obstruction, or compression. However, there has been no reported case discussing about IE complicated with nonobstructive STEMI.

Patient Concerns: In this report, we report a 38-year-old female suffering from intermittent fever and was later diagnosed as IE. Read More

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November 2018
1 Read

Crystalloid fluid administration was associated with outcomes in pediatric patients with severe sepsis or septic shock.

Medicine (Baltimore) 2018 Nov;97(48):e12663

Department of Pediatric General Surgery and Liver Transplantation.

Intravenous fluid prescription plays an important role in sepsis management, which may be associated with patient prognosis. The objective of the present study was to determine if the administration of crystalloid fluids is associated with clinical outcome for patients with severe sepsis and septic shock.The medical records of 79 patients with severe sepsis or septic shock at an academic tertiary care hospital between 2011 and 2016 were reviewed retrospectively. Read More

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November 2018

Outcomes of Dual Mobility Acetabular Cups in Total Hip Arthroplasty Patients.

Surg Technol Int 2018 11 30;34. Epub 2018 Nov 30.

Department of Orthopaedic Surgery, Lenox Hill Hospital Northwell Health, New York, New York.

Background: Instability can account for over 20% of all revision total hip arthroplasties (THAs). Although a number of surgical techniques have been developed to limit the number of dislocations, prevention still remains a challenge. More recently, dual mobility (DM) cups have been developed to potentially target this problem. Read More

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November 2018
3 Reads