166,964 results match your criteria Sepsis Bacterial


Preterm Prelabor Rupture of Membranes: Outcomes with Expectant Management until 34 versus 35 Weeks.

Am J Perinatol 2018 Dec 15. Epub 2018 Dec 15.

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Rochester Medical Center, Rochester, New York.

Objective:  To evaluate outcomes with expectant management of preterm prelabor rupture of membranes (PROM) until 35 weeks versus immediate delivery at ≥34 weeks.

Study Design:  This was a multicenter retrospective cohort study of singletons with preterm PROM at >20 weeks from 2011 through 2017. Groups were defined as expectant management until 35 weeks versus immediate delivery at ≥34 weeks. Read More

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December 2018
2 Reads

Intentional early delivery versus expectant management for preterm premature rupture of membranes at 28-32 weeks' gestation: A multicentre randomized controlled trial (MICADO STUDY).

Eur J Obstet Gynecol Reprod Biol 2018 Dec 5;233:30-37. Epub 2018 Dec 5.

Department of Obstetrics and Gynecology, Hôpital Femme Mère Enfant, Hospices Civils de Lyon, Lyon, France.

Objectives: Preterm premature rupture of fetal membranes (PPROM) exposes the fetus to preterm birth, and optimal timing for delivery is controversial. The aim of this study was to compare intentional early delivery ("active management") with expectant management in very preterm birth (28-32 weeks).

Study Design: We conducted a prospective randomized controlled trial with intent-to-treat analysis, at 19 tertiary-care hospitals in France and 1 in Geneva, Switzerland. Read More

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December 2018

Effectiveness of Fosfomycin Tromethamine Prophylaxis in Preventing Infection Following Ultrasound-guided Prostate Needle Biopsies: Results from a Large Canadian Cohort.

J Glob Antimicrob Resist 2018 Dec 12. Epub 2018 Dec 12.

Department of Microbiology and Infectious Diseases, Université de Sherbrooke, 3001 12e avenue nord, Sherbrooke, QC, Canada J1H5N4; Centre de recherche du Centre hospitalier universitaire de Sherbrooke, 3001 12e avenue nord, Sherbrooke, QC, Canada J1H5N4,. Electronic address:

Background: Rates of infection following ultrasound-guided transrectal prostate needle biopsy (TRUSPB) are increasing. We aimed to evaluate the effectiveness of fosfomycin tromethamine (FMT) prophylaxis in preventing post-TRUSPB infectious complications.

Methods: This nested case-control study included patients who underwent TRUSPB in a Canadian tertiary care hospital, and developed post-TRUSPB bacteremia or urinary tract infections. Read More

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December 2018

Biology of preeclampsia: Combined actions of angiogenic factors, their receptors and placental proteins.

Biochim Biophys Acta Mol Basis Dis 2018 Dec 12. Epub 2018 Dec 12.

Division of Cell Biology, Histology and Embryology, Gottfried Schatz Research Center, Medical University of Graz, Graz, Austria. Electronic address:

Although massive efforts have been undertaken to elucidate the etiology of the pregnancy syndrome preeclampsia, its developmental origin remains a mystery. Most efforts of the last decade have focused on biomarkers to predict and/or diagnose preeclampsia, including the anti-angiogenic factor sFlt-1 (soluble fms-like tyrosin kinase-1), the angiogenic factor PGF (placental growth factor) and PP13 (placental protein 13). The origins of these marker proteins are still under debate, and so far their actions have only been describe separate from each other. Read More

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December 2018

Oxidative stress in the choroid plexus contributes to blood-cerebrospinal fluid barrier disruption during sepsis development.

Microvasc Res 2018 Dec 12. Epub 2018 Dec 12.

Laboratory of Neurobiology of Inflammatory and Metabolic Processes, Graduate Program in Health Sciences, Health Sciences Unit, University of South Santa Catarina, Tubarão, SC, Brazil. Electronic address:

Background: The choroid plexus (CP), main component of blood-cerebrospinal fluid barrier (BCSFB), protects the brain from peripheral inflammation similar to the blood-brain barrier. Thus, CP is considered a critical target site of oxidative damage, which in sepsis oxidative stress is likely to be a major step in the development of brain damage. Functional alterations in CP may be associated with sepsis-induced brain injury. Read More

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December 2018
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Epidemiology and Effects of Bacterial Infections in Patients With Cirrhosis Worldwide.

Gastroenterology 2018 Dec 12. Epub 2018 Dec 12.

Unit of Internal Medicine and Hepatology (UIMH), Department of Medicine - DIMED, University of Padova, Padova, Italy. Electronic address:

Background And Aims: Bacterial infections are common and life-threatening in patients with cirrhosis. Little is known about the epidemiology of bacterial infections in different regions. We performed a multicenter prospective intercontinental study to assess the prevalence and outcomes of bacterial and fungal infections in patients with cirrhosis. Read More

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December 2018
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Phage-based assay for rapid detection of bacterial pathogens in blood by Raman spectroscopy.

J Immunol Methods 2018 Dec 12. Epub 2018 Dec 12.

Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale F. Stagno d'Alcontres 31, 98166 Messina, Italy. Electronic address:

Sepsis is a systemic inflammatory response ensuing from presence and persistence of microorganisms in the bloodstream. The possibility to identify them at low concentrations may improve the problem of human health and therapeutic outcomes. So, sensitive and rapid diagnostic systems are essential to evaluate bacterial infections during the time, also reducing the cost. Read More

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December 2018
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FcRγ deficiency improves survival in experimental sepsis by down-regulating TLR4 signaling pathway.

Immunol Res 2018 Dec 14. Epub 2018 Dec 14.

Department of Oncology, General Hospital of Chinese PLA, 28 Fuxing Road, Beijing, 100853, China.

Fc receptor common γ signaling chain (FcRγ), a common subunit shared by Fc receptors (FcγRI, III, IV, FcαRI, and FcεRI), is an important immune regulator both in innate and adaptive immunity. Previous studies have shown that FcRγ was a potential target of inflammatory diseases, whereas the role of FcRγ in sepsis has been poorly understood. In this study, we found that deficiency of FcRγ resulted in increased survival in lipopolysaccharide (LPS)/D-galactosamine and E. Read More

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December 2018

Granisetron protects polymicrobial sepsis-induced acute lung injury in mice.

Biochem Biophys Res Commun 2018 Dec 11. Epub 2018 Dec 11.

Department of Pathophysiology, Guangdong Provincial Key Laboratory of Proteomics, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China; State Key Laboratory of Organ Failure Research, Southern Medical University, Guangzhou, China. Electronic address:

Sepsis is a serious condition with a high mortality rate worldwide. Granisetron is an anti-nausea drug for patients undergoing chemotherapy. Here we aimed to identify the novel effect of granisetron on sepsis-induced acute lung injury (ALI). Read More

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December 2018
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Implant-related sepsis in lower limb fractures following gunshot injuries in the civilian population: A systematic review.

Injury 2018 Dec 5. Epub 2018 Dec 5.

Division of Orthopaedics, Department of Surgical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, South Africa; Countess of Chester Hospital, Chester, UK.

Introduction: The management of long bone lower limb fractures secondary to gunshot wounds (GSWs) in the civilian setting are complex and there is currently no consensus regarding the optimal approach to managing such fractures. This study aims to address the relationship of implant related sepsis in fractures secondary to GSWs.

Methods: A systematic review of the literature was performed on both Pubmed and Scopus databases that look at fractures caused by GSWs in the lower limb. Read More

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December 2018

MicroRNA Expression is Associated with Sepsis Disorders in Critically Ill Polytrauma Patients.

Cells 2018 Dec 13;7(12). Epub 2018 Dec 13.

Faculty of Medicine, "Victor Babes" University of Medicine and Pharmacy, 300041 Timisoara, Romania.

A critically ill polytrauma patient is one of the most complex cases to be admitted to the intensive care unit, due to both the primary traumatic complications and the secondary post-traumatic interactions. From a molecular, genetic, and epigenetic point of view, numerous biochemical interactions are responsible for the deterioration of the clinical status of a patient, and increased mortality rates. From a molecular viewpoint, microRNAs are one of the most complex macromolecular systems due to the numerous modular reactions and interactions that they are involved in. Read More

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December 2018
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Distribution of Late-Onset Neonatal Sepsis Pathogens Differs in Inpatient and Outpatient Settings.

Am J Perinatol 2018 Dec 14. Epub 2018 Dec 14.

Department of Pediatrics, New York University School of Medicine, New York, New York.

Objective:  We sought to examine pathogen distribution and clinical presentation of late-onset sepsis (LOS) at an urban tertiary care center.

Study Design:  We performed a retrospective review of all culture-confirmed cases of LOS presenting to our institution from 2013 to 2017. Medical records were evaluated for demographic information, sepsis risk factors, encounter location, and clinical outcome. Read More

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December 2018

Effects of antiplatelet therapy on the mortality rate of patients with sepsis: A meta-analysis.

J Crit Care 2018 Dec 5;50:162-168. Epub 2018 Dec 5.

Department of Intensive Care Unit, The First Hospital of China Medical University, Nanjing Bei Street 155, Shenyang 110001, Liaoning Province, PR China. Electronic address:

Purpose: Abnormal platelet activation plays an important role in the development of sepsis. The effect of antiplatelet drugs on the outcome of patients with sepsis remains unclear. This meta-analysis aimed to determine the effect of antiplatelet drugs on the prognosis of patients with sepsis. Read More

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December 2018

Antiviral effects of selected nucleoside analogs against human parechoviruses A1 and A3.

Antiviral Res 2018 Dec 11. Epub 2018 Dec 11.

KU Leuven, Department of Microbiology and Immunology, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, Leuven, Belgium. Electronic address:

Parechoviruses A (HPeV, Picornaviridae) are neglected human pathogens that cause sepsis-like illness and severe neurological complications in infants. There are no antivirals available for the treatment of HPeV infections. We here report on cell-based assays that allow for medium-throughput antiviral screening of compound libraries against HPeV. Read More

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December 2018
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Comparison of PCR, Fluorescent in Situ Hybridization and Blood Cultures for Detection of Bacteremia in Children and Adolescents During Antibiotic Therapy.

Pol J Microbiol 2018 ;67(4):479-486

Chair of Microbiology, Department of Molecular Medical Microbiology, Faculty of Medicine, Jagiellonian University Medical College , Cracow , Poland.

The gold standard in microbiological diagnostics of bacteremia is a blood culture in automated systems. This method may take several days and has low sensitivity. New screening methods that could quickly reveal the presence of bacteria would be extremely useful. Read More

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January 2018

[The role of fraction analysis of ferritin in diagnostic of secondary hemophagocyte syndrome].

Klin Lab Diagn 2018 ;63(1):21-27

The Federal state budget educational institution of higher education "The Pavlov First Saint Petersburg State Medical University" of Minzdrav of Russia, 197022, St. Petersburg, Russia.

The secondary hemophagocytic syndrome is a life-threatening condition characterized by non-specifc manifestations: systemic inflammatory reaction, cytopenia, liver affection, high content of ferritin in blood serum. One of manifestations of secondary hemophagocytic syndrome is decreasing of level of glycated ferritin in blood serum expressed in percentage of total level. The detection of glycated ferritin can be applied for a differentiated diagnosis with cli9nically similar conditions, including septic process. Read More

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January 2018

[Acute kidney injury as a risk marker for hospital readmission: a single-center pilot study in the general population of the Parma area].

G Ital Nefrol 2018 Dec;35(6)

Unità di Fisiopatologia dell'Insufficienza Renale Acuta e Cronica - Dipartimento di Medicina e Chirurgia, Università degli Studi di Parma.

Acute Kidney Injury (AKI) is an important issue for the healthcare system, as it is associated with high mortality and increased risk of readmission, with consequent elevated healthcare resource utilization. We investigated the incidence of AKI based on the examination of the discharge cards of all patients admitted between January 1 2011 and December 31 2015 at the Parma University Hospital, as well as the frequency and type of 30-day hospital readmission in the patients discharged with a first AKI diagnosis (index admission). The mean pooled 5-year incidence of AKI was 2. Read More

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December 2018

Evaluation and Predictors for Nasogastric Tube Associated Pressure Ulcers in Critically Ill Patients.

Isr Med Assoc J 2018 Dec;20(12):731-736

Department of Intensive Care Medicine, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.

Background: Nasal device-related pressure ulcers are scarcely addressed in the literature.

Objectives: To assess the prevalence and severity of cutaneous and mucosal nasogastric tube (NGT)-associated pressure ulcers (PU) in critically ill patients and to define predictors for their formation.

Methods: A single center observational study of intensive care unit patients with a NGT for more than 48 hours was conducted. Read More

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December 2018
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Preoperative serum albumin as a predictor of complications following total hip replacement in patients with rheumatoid arthritis.

Acta Ortop Mex 2018 Jul-Aug;32(4):193-197

Trauma and Orthopaedic Surgery Hospitals. UMAE «Dr. Victorio de la Fuente Narváez», Mexico City.

Background: Rheumatoid arthritis is a chronic inflammatory disease characterized by polyarthritis with progressive articular wear, immunologic abnormalities and increasing physical limitation. Surgical correction with hip replacement comes as a successful solution for patients with advanced articular destruction. Following intervention, surgical site infection (SSI), venous thromboembolism, sepsis, renal and major cardiovascular complications are among the most cited in the literature. Read More

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December 2018

Extracellular Vesicle-Mimetic Ghost Nanovesicles for Delivering Anti-Inflammatory Drugs to Mitigate Gram-Negative Bacterial Outer Membrane Vesicle-Induced Systemic Inflammatory Response Syndrome.

Adv Healthc Mater 2018 Dec 14:e1801082. Epub 2018 Dec 14.

Department of Life Sciences, Pohang University of Science and Technology (POSTECH), 77 Cheongam-ro, Nam-gu, Pohang, 37673, Republic of Korea.

Sepsis is one of the major causes of death in hospital patients and is represented by systemic inflammatory response syndrome (SIRS) associated with infection. Gram-negative bacteria including Escherichia coli can provoke sepsis by stimulating the immune systems. Outer membrane vesicles (OMVs), nanosized vesicular structures derived from Gram-negative bacteria, contain several pathogen-associated molecular patterns, and are demonstrated to mediate SIRS. Read More

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December 2018

History-indicated cervical cerclage in the management of twin pregnancy.

Ultrasound Obstet Gynecol 2018 Dec 13. Epub 2018 Dec 13.

Department of Obstetrics and Gynecology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.

Objectives: Cervical cerclage when performed in twin gestation has been reported to be associated with poor outcome. However, the role of first-trimester history-indicated cerclage among women with twin pregnancy and a prior history of preterm birth has not been studied. We aimed to assess pregnancy outcomes among women with twin pregnancy who underwent first-trimester history-indicated cervical cerclage compared to expectant management. Read More

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December 2018
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Hemofiltration for neuroprotection in acute ischemic stroke: a prospective, pilot study.

Acta Neurol Scand 2018 Dec 13. Epub 2018 Dec 13.

National Research Oncology and Transplantation Center, Astana, Kazakhstan.

Background: Hemofiltration reduces blood levels of cytokines, glutamate and other substances that increase the risk of stroke-associated neurodegeneration. This study aimed to assess the safety and efficacy of hemofiltration in acute ischemic stroke patients.

Methods: 37 patients (mean age 56±16 years) who had an ischemic stroke within the previous 12 hours were randomized to receive hemofiltration for 36 hours (n=19) or standard treatment (n=18). Read More

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December 2018
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Recipient sepsis caused by Lactococcus garvieae contamination of platelets from a donor with colon cancer.

Vox Sang 2018 Dec 12. Epub 2018 Dec 12.

Central Blood Institute, Blood Service Headquarters, Japanese Red Cross Society, Tokyo, Japan.

Lactococcus garvieae is a well-known fish pathogen that has low virulence in humans and is rarely isolated from the blood cultures of endocarditis patients. We describe herein the first reported case of transfusion-transmitted L. garvieae sepsis caused by a contaminated platelet concentrate from a donor who consumed raw octopus before blood donation. Read More

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December 2018

Incidence, Causes, and Correlates of Maternal Near-Miss Morbidity: a multi-centre cross-sectional study.

BJOG 2018 Dec 12. Epub 2018 Dec 12.

University of Michigan, Ann Arbor, Michigan, USA.

Objective: To explore the incidence and factors associated with maternal near-miss.

Design: Cross-sectional study with an embedded case-control study.

Setting: Three tertiary referral hospitals in southern Ghana. Read More

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December 2018

Maternal probiotic supplementation for prevention of morbidity and mortality in preterm infants.

Cochrane Database Syst Rev 2018 Dec 12;12:CD012519. Epub 2018 Dec 12.

University of Vermont Medical Center, Burlington VT, USA.

Background: Inflammation may contribute to preterm birth and to morbidity of preterm infants. Preterm infants are at risk for alterations in the normal protective microbiome. Oral probiotics administered directly to preterm infants have been shown to decrease the risk for severe necrotizing enterocolitis (NEC) as well as the risk of death, but there are safety concerns about administration of probiotics directly to preterm infants. Read More

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December 2018

Cytokine and molecular networks in sepsis cases: a network biology approach.

Eur Cytokine Netw 2018 Sep;29(3):103-111

Department of Laboratory Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Laboratory for Development and Evaluation Center, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea.

Sepsis is a life-threatening condition of organ dysfunction caused by a dysregulated host immune response to infection. We performed network analysis of cytokine molecules and compared network structures between a systematic inflammatory response syndrome (SIRS) or normal control (NC) group and a sepsis group. We recruited SIRS (n = 33) and sepsis (n = 89) patients from electronic medical records (EMR) according to whether data on PCT, CRP, interleukin (IL)-1β, IL-2, IL-4, IL-5, IL-6, IL-9, IL-10, IL-12p70, IL-13, IL-17, IL-22, TNF-α, and IFN-γ levels were available. Read More

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September 2018
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Nonconventional Therapeutics against .

Microbiol Spectr 2018 Nov;6(6)

Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232.

is one of the most important human pathogens that is responsible for a variety of diseases ranging from skin and soft tissue infections to endocarditis and sepsis. In recent decades, the treatment of staphylococcal infections has become increasingly difficult as the prevalence of multi-drug resistant strains continues to rise. With increasing mortality rates and medical costs associated with drug resistant strains, there is an urgent need for alternative therapeutic options. Read More

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November 2018

Hospital patients with severe wounds: early evidence on the impact of Medicare payment changes on treatment patterns and outcomes.

J Med Econ 2018 Dec 14:1-17. Epub 2018 Dec 14.

a KNG Health Consulting, LLC , 15245 Shady Grove Road , Rockville , Maryland 20850 , USA.

Aims: We examine the effects of recent changes in Medicare long-term care hospital (LTCH) payments on treatment patterns and outcomes for severe wound patients discharged from short-term acute care hospitals (STACHs).

Materials And Methods: We used the rolling implementation of a new Medicare payment policy to develop a difference-in-difference model. The study population consisted of Medicare beneficiaries subjected to the payment policy changes and hospitalized for stage 3, 4, or unstageable wounds; nonhealing surgical wounds; and fistula. Read More

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December 2018

[Role of prebiotics and probiotics in the functionality of the microbiota in the patients receiving enteral nutrition].

Nutr Hosp 2018 Apr 3;35(Spec no2):18-26. Epub 2018 Apr 3.

.

Set of resident microorganisms in our body that are responsible for the absorption of nutrients and the maintenance of health is named microbiota. The microbiota´s role is protective, trophic and metabolic. Different groups of microbiota intestinal name enterotypes, each one of them are in relation to specific dietary habits. Read More

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A Comparative Review of Neutrophil Extracellular Traps in Sepsis.

Front Vet Sci 2018 28;5:291. Epub 2018 Nov 28.

Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University of California, Davis Davis, CA, United States.

Sepsis is the leading cause of critical illness and mortality in human beings and animals. Neutrophils are the primary effector cells of innate immunity during sepsis. Besides degranulation and phagocytosis, neutrophils also release neutrophil extracellular traps (NETs), composed of cell-free DNA, histones, and antimicrobial proteins. Read More

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November 2018

PVT1 regulates inflammation and cardiac function via the MAPK/NF-κB pathway in a sepsis model.

Exp Ther Med 2018 Dec 1;16(6):4471-4478. Epub 2018 Oct 1.

Department of Critical Care Medicine, The Second Hospital of Lanzhou University, Lanzhou, Gansu 730000, P.R. China.

The aim of the present study was to investigate the role of plasmacytoma variant translocation gene 1 (PVT1) in the occurrence and development of sepsis-induced inflammation and cardiac dysfunction and its underlying mechanism. A sepsis rat model was first established by cecal ligation and puncture. The mRNA levels of PVT1 and microRNA-143 in the myocardial tissues of rats were detected by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) analysis. Read More

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December 2018

Late onset neonatal acute kidney injury: results from the AWAKEN Study.

Pediatr Res 2018 Dec 13. Epub 2018 Dec 13.

Golisano Children's Hospital, University of Rochester, Rochester, NY, USA.

Background: Most studies of neonatal acute kidney injury (AKI) have focused on the first week following birth. Here, we determined the outcomes and risk factors for late AKI (>7d).

Methods: The international AWAKEN study examined AKI in neonates admitted to an intensive care unit. Read More

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December 2018
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Treatment with a 5-day versus a 10-day schedule of decitabine in older patients with newly diagnosed acute myeloid leukaemia: a randomised phase 2 trial.

Lancet Haematol 2018 Dec 10. Epub 2018 Dec 10.

Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address:

Background: Hypomethylating agents, such as decitabine, are the standard of care for older patients with newly diagnosed acute myeloid leukaemia. Single-arm studies have suggested that a 10-day schedule of decitabine cycles leads to better outcomes than the usual 5-day schedule. We compared the efficacy and safety of these two schedules. Read More

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December 2018

Factors associated with acute kidney injury in the Helsinki Burn Centre in 2006-2015.

Scand J Trauma Resusc Emerg Med 2018 Dec 13;26(1):105. Epub 2018 Dec 13.

Helsinki Burn Centre, Department of Plastic Surgery, Helsinki University Hospital and University of Helsinki, PO. Box 800, FI-00029 HUS, Helsinki, Finland.

Background: Acute kidney injury (AKI) is a common complication in severe burns and can lead to significantly poorer outcomes. Although the prognosis has improved in recent decades, the mortality of AKI remains considerable. We investigated the factors that increase the risk of AKI and death after severe burn injury. Read More

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December 2018

[Role of prebiotics and probiotics in the functionality of the microbiota in the patients receiving enteral nutrition].

Nutr Hosp 2018 Apr 3;0(0):18-26. Epub 2018 Apr 3.

.

Set of resident microorganisms in our body that are responsible for the absorption of nutrients and the maintenance of health is named microbiota. The microbiota´s role is protective, trophic and metabolic. Different groups of microbiota intestinal name enterotypes, each one of them are in relation to specific dietary habits. Read More

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April 2018
1 Read

Validation of the REGARDS Severe Sepsis Risk Score.

J Clin Med 2018 Dec 11;7(12). Epub 2018 Dec 11.

Department of Medicine, Weill-Cornell Medical Center, New York, NY 10065, USA.

There are no validated systems for characterizing long-term risk of severe sepsis in community-dwelling adults. We tested the ability of the REasons for Geographic and Racial Differences in Stroke-Severe Sepsis Risk Score (REGARDS-SSRS) to predict 10-year severe sepsis risk in separate cohorts of community-dwelling adults. We internally tested the REGARDS-SSRS on the REGARDS-Medicare subcohort. Read More

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December 2018

Red-flag sepsis and SOFA identifies different patient population at risk of sepsis-related deaths on the general ward.

Medicine (Baltimore) 2018 Dec;97(49):e13238

Department of Anaesthesia, Intensive Care and Pain Medicine, Division of Population Medicine, Cardiff University, Heath Park Campus, Cardiff.

Controversy exists regarding the best diagnostic and screening tool for sepsis outside the intensive care unit (ICU). Sequential organ failure assessment (SOFA) score has been shown to be superior to systemic inflammatory response syndrome (SIRS) criteria, however, the performance of "Red Flag sepsis criteria" has not been tested formally.The aim of the study was to investigate the ability of Red Flag sepsis criteria to identify the patients at high risk of sepsis-related death in comparison to SOFA based sepsis criteria. Read More

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December 2018

Routine versus Selective Fortification of Human Milk with Powdered Human Milk Fortifiers in Very Low Birth Weight (VLBW) Preterm Infants: A Retrospective Pre-Post Cohort Study.

J Trop Pediatr 2018 Dec 12. Epub 2018 Dec 12.

Department of Paediatrics and Neonatology, Cloudnine Hospital, Gurgaon, Haryana, India.

Objectives: The objective of this study was to show the effects of routine vs. selective fortification of human milk (HM) on short-term growth and metabolic parameters.

Methods: Single-centre retrospective pre-post cohort study in India. Read More

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December 2018

Low D-dimer levels in sepsis: Good or bad?

Thromb Res 2018 Dec 5;174:13-15. Epub 2018 Dec 5.

Dipartimento di Scienze e Biomediche ed Oncologia Umana, Università degli Studi di Bari Aldo Moro, Bari, Italy. Electronic address:

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December 2018

Rapid antibiotic susceptibility testing from blood culture bottles with species agnostic real-time polymerase chain reaction.

PLoS One 2018 13;13(12):e0209042. Epub 2018 Dec 13.

Diagnostic Systems Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, United States of America.

Development and implementation of rapid antimicrobial susceptibility testing is critical for guiding patient care and improving clinical outcomes, especially in cases of sepsis. One approach to reduce the time-to-answer for antimicrobial susceptibility is monitoring the inhibition of DNA production, as differences in DNA concentrations are more quickly impacted compared to optical density changes in traditional antimicrobial susceptibility testing. Here, we use real-time PCR to rapidly determine antimicrobial susceptibility after short incubations with antibiotic. Read More

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December 2018

Strategies to improve antibiotic use in the neonatal ICU.

Curr Opin Pediatr 2018 Dec 12. Epub 2018 Dec 12.

Division of Pediatric Infectious Diseases, Department of Pediatrics, University of California Los Angeles, Los Angeles, California, USA.

Purpose Of Review: Neonates are at a high risk of infection and may have nonspecific signs of sepsis. Accordingly, they are heavily exposed to antimicrobials. Neonates are also uniquely at risk of both short-term and long-term complications from antibiotic exposure. Read More

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December 2018

Expression changes of CD177 and MPO as novel biomarkers in lung tissue of CLP model rats

Turk J Med Sci 2018 12 12;48(6):1321. Epub 2018 Dec 12.

National Institute of Scientific Research (INRS-ETE), University of Quebec, Quebec City, Canada

Background/aim: Sepsis is an unregulated systemic response to microbial invasion that can lead to multiple organ failure. This study aims at investigating the relationships among myeloperoxidase (MPO) and CD177 in major organ systems including whole blood, liver, and lung tissues in septic rats.

Materials And Methods: Sepsis was induced by cecal ligation and puncture (CLP) in female Wistar rats. Read More

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December 2018

Mini-percutaneous nephrolithotomy for pediatric complex renal calculus disease: one-stage or two-stage?

Int Urol Nephrol 2018 Dec 12. Epub 2018 Dec 12.

Department of Urology, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.

Objectives: To compare two different treatment strategies, one-stage and two-stage multi-tract mini-percutaneous nephrolithotomy (mt-mPCNL), for pediatric complex renal calculus disease.

Methods: Between the period of July 2016 and July 2018, a total of 36 children aged 15 years and younger, with complex renal calculi disease, who underwent total ultrasound-guided mt-mPCNL by a single experienced urologist were enrolled in our study. All patients were assigned either to Group 1 (n = 18) who received one-stage mt-mPCNL or Group 2 (n = 18) who received planned two-stage mt-mPCNL. Read More

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December 2018

Early Inflammatory Markers for the Diagnosis of Late-Onset Sepsis in Neonates: The Nosodiag Study.

Front Pediatr 2018 13;6:346. Epub 2018 Nov 13.

Service de Pédiatrie II, Hôpital de Hautepierre, Strasbourg, France.

Early diagnosis is essential to improve the treatment and prognosis of newborn infants with nosocomial bacterial infections. Although cytokines and procalcitonin (PCT) have been evaluated as early inflammatory markers, their diagnostic properties have rarely been compared. This study evaluated and compared the ability of individual inflammatory markers available for clinician (PCT, semi-quantitative determination of IL-8) and of combinations of markers (CRP plus IL-6 or quantitative or semi-quantitative determination of IL-8) to diagnose bacterial nosocomial infections in neonates. Read More

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November 2018

Aortic valve endocarditis with A rare zoonosis.

Infect Dis Rep 2018 Nov 6;10(3):7770. Epub 2018 Nov 6.

National Centre for Tropical Infectious Diseases, Haukeland University Hospital, Bergen, Norway.

has an economic impact in animal husbandry by causing infection in swine, sheep and poultry. is present in the surface mucoid slime on fish, although fishes do not seem to be affected. Humans can get infected, maost often through occupational exposure and may suffer typical erysipeloid infection on exposed skin such as on hands and fingers, or deeper skin infections, and sometimes sepsis and endocarditis, associated with high case-fatality rate. Read More

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November 2018

Regulatory role of miRNA-26a in neonatal sepsis.

Exp Ther Med 2018 Dec 19;16(6):4836-4842. Epub 2018 Sep 19.

Department of Pediatrics, The Second Hospital of Shandong University, Jinan, Shandong 250000, P.R. China.

The present study aimed to investigate the expression of microRNA (miRNA) 26a in blood mononuclear cells and serum in neonatal sepsis, as well as its role in the disease pathogenesis. In total 28 cases of neonatal sepsis were included in the study. The mRNA expression levels of miRNA-26a and interleukin (IL)-6 in the blood mononuclear cells and serum samples were detected by reverse transcription-quantitative polymerase chain reaction. Read More

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December 2018

Expression of microRNA-23b in patients with sepsis and its effect on leukocytes and the expression of E-selectin and ICAM-1.

Exp Ther Med 2018 Dec 18;16(6):4707-4711. Epub 2018 Sep 18.

Translational Medicine Center of Sepsis, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, P.R. China.

The expression of microRNA-23b in peripheral blood leukocytes of patients with sepsis was investigated to assess the correlations with leukocyte, E-selectin, ICAM-1 and disease severity. The expression of microRNA-23b in peripheral blood leukocytes from 87 patients with sepsis, 50 patients with systemic inflammatory response syndrome (SIRS) and 50 normal controls were measured by reverse transcription-quantitative PCR (RT-qPCR), and stability of microRNA-23b was evaluated. Enzyme-linked immunosorbent assay (ELISA) was used to detect E-selectin and ICAM-1. Read More

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December 2018

MicroRNA-21 inhibits lipopolysaccharide-induced acute lung injury by targeting nuclear factor-κB.

Exp Ther Med 2018 Dec 24;16(6):4616-4622. Epub 2018 Sep 24.

Orthopedics Department, Traditional Chinese Medical Hospital of Zhuji, Zhuji, Zhejiang 311800, P.R. China.

Acute lung injury (ALI) is a frequent, but severe complication following sepsis in patients with critical illness. The present study aimed to investigate the potential role of microRNA-21 (miR-21) in the regulation of inflammation in the ALI induced by lipopolysaccharide (LPS) and . The levels of inflammatory cytokines, tumor necrosis factor (TNF)-α, interleukin (IL)-6, IL-1β and IL-10, and the level of miR-21 expression were measured in the lungs of LPS-induced ALI rats and NR8383 alveolar macrophages (AMs). Read More

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December 2018

Antimicrobial resistance in bacterial pathogens among hospitalised patients with severe invasive infections.

Exp Ther Med 2018 Dec 14;16(6):4499-4510. Epub 2018 Sep 14.

Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.

The most severe infections are invasive infections, due to the fact that the germs can accumulate in multiple sites and produce a body-wide infection known as sepsis. Septic shock has the highest mortality rate among non-traumatic medical conditions. In this study, we aimed to evaluate the incidence and prevalence of invasive infections in a hospital environment. Read More

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December 2018

Park 7: A Novel Therapeutic Target for Macrophages in Sepsis-Induced Immunosuppression.

Front Immunol 2018 13;9:2632. Epub 2018 Nov 13.

West China Hospital Emergency Department, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, and Collaborative Innovation Center of Biotherapy, Chengdu, China.

Sepsis remains a serious and life-threatening condition with high morbidity and mortality due to uncontrolled inflammation together with immunosuppression with few therapeutic options. Macrophages are recognized to play essential roles throughout all phases of sepsis and affect both immune homeostasis and inflammatory processes, and macrophage dysfunction is considered to be one of the major causes for sepsis-induced immunosuppression. Currently, Parkinson disease protein 7 (Park 7) is known to play an important role in regulating the production of reactive oxygen species (ROS) through interaction with p47, a subunit of NADPH oxidase. Read More

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November 2018