708 results match your criteria Sentinel Lymph Node Biopsy in Patients With Squamous Cell Carcinoma


Robot-assisted real-time sentinel lymph node mapping in oral cavity cancer: preliminary experience.

J Robot Surg 2020 Jun 27. Epub 2020 Jun 27.

Division of Head and Neck Surgery, Department of Surgery, The University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong, China.

This study aims to assess the feasibility of using indocyanine green and robotic near infra-red fluorescent imaging (Firefly) for sentinel lymph node biopsy in cN0 oral cavity cancer. Ten patients with early squamous cell carcinoma of the tongue (n = 8) and buccal mucosa (n = 2) were included. Peritumoral injection of 10 mg indocyanine green and real-time mapping of sentinel lymph nodes in the neck was performed using Firefly via a retro-auricular trans-hairline incision. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11701-020-01112-4DOI Listing

[Cutaneous squamous cell carcinoma].

Hautarzt 2020 Jun 24. Epub 2020 Jun 24.

Klinik für Dermatologie und Venerologie, Vivantes Klinikum Neukölln, Berlin, Deutschland.

Cutaneous squamous cell carcinoma (cSCC) is one of the most common cancers of the Caucasian population and accounts for 20% of all skin tumours. An S3 guideline of the German Guideline Program in Oncology has been available since 2019. The diagnosis is based on the clinical examination. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00105-020-04620-4DOI Listing

Importance of anatomical site in the metastases of auricular cutaneous squamous cell carcinoma: an observational study.

Br J Oral Maxillofac Surg 2020 May 13. Epub 2020 May 13.

Poole Hospital NHS Foundation Trust.

Malignancies of the auricular skin tend to metastasise to preauricular, parotid, facial, and level II (possibly to levels IV and V) lymph nodes in an unpredictable manner. Over the years, we have observed that this pattern of metastasis is commonly linked to lesions that involve the lower half of the ear. To find conclusive evidence based on this hypothetical observation, we retrospectively studied 108 patients who presented with squamous cell carcinoma (SCC) of the ear, and looked at the exact auricular site of the lesion at presentation, incidence of metastasis, nodal involvement, treatment, and survival outcome. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bjoms.2020.04.029DOI Listing

Usefulness of Sentinel Lymph Node Biopsy for Oral Cancer: A Systematic Review and Meta-Analysis.

Laryngoscope 2020 May 13. Epub 2020 May 13.

Department of Otolaryngology-Head and Neck Surgery, Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea.

Objective: We assessed the diagnostic accuracy of sentinel lymph node biopsy (SLNB) for detecting neck nodal metastasis in early oral squamous cell carcinoma (OSCC) as an alternative to elective neck dissection.

Study Design: A systematic search for relevant literature was conducted in the PubMed, SCOPUS, Embase, Web of Science, and Cochrane databases.

Methods: Two reviewers individually searched the five databases up to November 2019. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/lary.28728DOI Listing

Sentinel lymph node biopsy for high-thickness cutaneous squamous cell carcinoma.

Arch Dermatol Res 2020 May 8. Epub 2020 May 8.

Department of Dermatology and Center for Dermatologic Surgery, Eberhard-Karls University of Tuebingen, Liebermeisterstraße 25, 72076, Tübingen, Germany.

Squamous cell carcinomas are among the most common skin tumors and show a risk of metastasis depending on various factors such as tumor thickness, localization, histological subtype and immune status of the patient. Sentinel lymph node biopsy (SLNB) SLNB represents a possibility for assessing the locoregional lymph node status. In this study, the role of the SLNB in lymph node status and survival was analyzed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00403-020-02082-1DOI Listing

Impact of a prognostic 40-gene expression profiling test on clinical management decisions for high-risk cutaneous squamous cell carcinoma.

Curr Med Res Opin 2020 May 18:1-6. Epub 2020 May 18.

NYU Grossman School of Medicine, New York, NY, USA.

To determine how results from a prognostic 40-gene expression profiling (40-GEP) test would impact clinician management decisions and how their choices would align with a National Comprehensive Cancer Network (NCCN) compliant, risk-directed management plan for high-risk cutaneous squamous cell carcinoma (cSCC). Clinicians attending a national dermatology conference were presented with 40-GEP test validation data. They were asked to rate clinicopathological features and molecular test results to assess their opinion of how concerning each is to cSCC prognosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/03007995.2020.1763283DOI Listing

Can Sentinel Lymph Node Biopsy Predict Various Levels of Echelon Nodes in Oral Cancers?

Int Arch Otorhinolaryngol 2020 Apr 4;24(2):e125-e131. Epub 2019 Nov 4.

Department of Pathology, Post-Graduate Institute of Medical Education and Research, Chandigarh, Chandigarh, India.

 The efficacy of sentinel node biopsy in early stage oral cancer is well established. Its evolving role can be reinforced by further studies.  Analyzing the predictability of the levels of echelon nodes for various oral cavity tumor subsites on sentinel node biopsy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/s-0039-1695762DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6828571PMC

Impact of partnership status on clinical outcomes of patients with vulvar squamous cell carcinoma and performance of sentinel lymph node biopsy.

Int J Gynecol Cancer 2020 May 16;30(5):583-589. Epub 2020 Mar 16.

Pathology, Immunology and Laboratory Medicine, Rutgers New Jersey Medical School, Newark, New Jersey, USA.

Objectives: Vulvar squamous cell carcinoma is a rare malignancy and lymph node involvement is the most significant prognostic factor. We aimed to evaluate the association between partnership status and mortality from vulvar squamous cell carcinoma, cancer stage at the time of presentation, and the decision for sentinel lymph node biopsy.

Methods: The US National Cancer Institute Surveillance, Epidemiology, and End Results (SEER) database was queried and different parameters were evaluated relative to partnership status. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/ijgc-2019-001001DOI Listing

European interdisciplinary guideline on invasive squamous cell carcinoma of the skin: Part 1. epidemiology, diagnostics and prevention.

Eur J Cancer 2020 Mar 26;128:60-82. Epub 2020 Feb 26.

Aix Marseille University, APHM Hospital, Marseille France.

Invasive cutaneous squamous cell carcinoma (cSCC) is one of the most common cancers in the white populations, accounting for 20% of all cutaneous malignancies. Factors implicated in cSCC etiopathogenesis include ultraviolet radiation exposure and chronic photoaging, age, male sex, immunosuppression, smoking and genetic factors. A collaboration of multidisciplinary experts from the European Dermatology Forum (EDF), the European Association of Dermato-Oncology (EADO) and the European Organisation of Research and Treatment of Cancer (EORTC) was formed to update recommendations on cSCC classification, diagnosis, risk stratification, staging and prevention, based on current literature, staging systems and expert consensus. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejca.2020.01.007DOI Listing

Evolution and outcomes of sentinel lymph node mapping in vulvar cancer.

Int J Gynecol Cancer 2020 03 18;30(3):383-386. Epub 2020 Feb 18.

Gynecology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York City, New York, USA.

Objectives: To characterize our institutional experience with sentinel lymph node (SLN) biopsy in patients with vulvar cancer. We describe the oncologic outcomes of these patients and the utilization of SLN detection techniques over time.

Methods: A retrospective analysis of all patients who underwent inguinofemoral SLN biopsy as part of their treatment for vulvar cancer at Memorial Sloan Kettering Cancer Center from January 1, 2000 to April 1, 2019. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/ijgc-2019-000936DOI Listing

Detection of Occult Metastases in Patients with T1 and T2 Stage Lower Lip Squamous Cell Carcinomas after Positive Lymphoscintigraphy.

Diagnostics (Basel) 2020 Feb 11;10(2). Epub 2020 Feb 11.

Department of Maxillofacial Surgery, Faculty of Medicine Pristina, 10000 Pristina, Kosovo.

The aim of this study was to detect lower lip squamous cell carcinomas (SCC) that had metastasized to the lymph nodes and to evaluate if neck dissection was necessary for patients with T1 or T2-stage lip cancer after a sentinel lymph node biopsy (SLNB). The study was conducted as a prospective clinical study to detect occult neck metastases in patients with T1 or T2 stage SCC of the lower lip. Thirty-one patients were eligible and underwent echo-ultrasound, computer tomography, magnetic resonance and lymphoscintigraphy (LSG) as diagnostic procedures. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/diagnostics10020097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7168259PMC
February 2020

A novel sentinel lymph node approach in oral squamous cell carcinoma.

Curr Pharm Des 2020 Feb 12. Epub 2020 Feb 12.

Division of ENT Diseases, Department of Clinical Sciences, Intervention and Technology, Karolinska Institutet, Stockholm. Sweden.

Background: Occult metastases are common in patients with oral squamous cell carcinoma (OSCC) which is why elective neck dissection, adjuvant radiotherapy or watchful waiting have been treatment options after surgical removal of the primary tumour. Sentinel lymph node biopsy (SLNB), has lately emerged as a novel possibility in treatment planning. Even though the SLNB technique is constantly improving, it has not yet been firmly established in the assessment of head and neck cancer. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1381612826666200213100750DOI Listing
February 2020

ICG-Guided Sentinel Lymph Node Sampling during Robotic Retroauricular Neck Dissection in cN0 Oral Cancer.

Otolaryngol Head Neck Surg 2020 Mar 11;162(3):410-413. Epub 2020 Feb 11.

Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, South Korea.

In this study, we sought to evaluate the clinical feasibility of indocyanine green (ICG)-guided sentinel lymph node (SLN) sampling during robotic retroauricular neck dissection (RAND) in patients with cN0 oral cancer. Nine adult patients diagnosed with T1 to T2 oral squamous cell carcinoma were consecutively recruited. All of them underwent transoral partial glossectomy and robotic RAND (levels I-III) simultaneously. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0194599819900264DOI Listing

One-step nucleic acid amplification for detecting lymph node metastasis of head and neck squamous cell carcinoma.

Oral Oncol 2020 Jan 28;102:104553. Epub 2020 Jan 28.

Head Neck Surgery Department, University Hospital, Rennes, France; Chemistry, Oncogenesis, Stress, Signaling COSS, INSERM 1242, Rennes 1 University, CLCC Eugene Marquis, Rue de la bataille Flandres Dunkerques, Rennes, France. Electronic address:

Background: In head and neck squamous cell carcinoma (HNSCC) 30% of cN0 patients have occult metastasis. LN invasion is a major prognostic factor. Sentinel lymph node (SLN) is an option for cN0 neck management. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.oraloncology.2019.104553DOI Listing
January 2020

The role of preoperative computerized tomography (CT) scan of the pelvis and groin in the management of clinically early staged vulva squamous cell carcinoma.

Gynecol Oncol 2020 May 24;157(2):444-449. Epub 2020 Jan 24.

Institute of Cancer and Genomic Sciences, College of Dental and Medical School, University of Birmingham, Edgbaston B15 2TT, United Kingdom; Pan Birmingham Gynaecological Cancer Centre, City Hospital, Birmingham B18 7QH, United Kingdom. Electronic address:

Introduction: Vulvar squamous cell carcinoma (VSCC) commonly metastasises through groin lymphatics. However, the use of pre-operative imaging in detecting inguinal nodal metastasis before staging surgery or to triage patients for sentinel node biopsy remains unclear. Here, we investigated if pre-operative CT scan, the imaging choice in our cancer centre, influences the overall course of VSCC management in those patients without clinical evidence of groin lymphadenopathy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ygyno.2020.01.031DOI Listing

Risk factors for failure of bilateral sentinel lymph node mapping in early-stage cervical cancer.

Gynecol Oncol 2020 01 12;156(1):93-99. Epub 2019 Dec 12.

Gynecologic and Breast Oncologic Surgery Department, Georges Pompidou European Hospital, Paris, France; Paris Descartes University, Sorbonne Paris Cité, Faculty of Medicine, Paris, France.

Background: The objective of this study was to determine clinical, tumoral and surgical factors associated with successful bilateral sentinel lymph node mapping (SBM) in early-stage cervical cancer.

Methods: We performed an ancillary work on the data of two prospective trials on SLN biopsy for FIGO IA-IIA cervical cancer (SENTICOL I & II). Patients having Sentinel lymph node (SLN) mapping for early-stage cervical cancer were included between 2005 and 2012 from 28 French oncologic centers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ygyno.2019.10.027DOI Listing
January 2020

Comparison of guidelines for the management of patients with high-risk and advanced cutaneous squamous cell carcinoma - a systematic review.

J Eur Acad Dermatol Venereol 2019 Dec;33 Suppl 8:25-32

Division of Evidence-Based Medicine (dEBM), Department of Dermatology, Venereology and Allergy, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany.

The management of high-risk cutaneous squamous cell carcinoma (cSCC) can be a challenge as evidence from high quality clinical trials is rare. Guideline developers are challenged to provide practical and useful guidance for clinicians even in the absence of good evidence. In order to compare treatment recommendations for high-risk and advanced cSCC among national and international guidelines and to extract the most precise guidance provided, a systematic search was carried out in guideline databases Medline and Embase with a cutoff of 4 March 2019. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jdv.15846DOI Listing
December 2019

Lymphatic mapping with SPECT-CT for evaluation of contralateral drainage in lateralized oropharyngeal cancers using an awake injection technique.

Head Neck 2020 Mar 28;42(3):385-393. Epub 2019 Nov 28.

Department of Otolaryngology - Head and Neck Surgery, Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, Ontario, Canada.

Background: Risk of contralateral nodal metastases in oropharyngeal squamous cell carcinoma (OPSCC) is currently based on clinical risk factors. We propose lymphatic mapping with single photon emission computed tomography (SPECT-CT) for tumor-specific delineation of lymphatic drainage to guide treatment.

Methods: Retrospective review of lymphatic drainage patterns in cT1-2 OPSCC and contralateral cN0 neck with a nonoperative, awake injection of 99 m-Tc sulfur colloid and SPECT-CT. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/hed.26011DOI Listing

Mapping of sentinel lymph node drainage using SPECT/CT to tailor elective nodal irradiation in head and neck cancer patients (SUSPECT-2): a single-center prospective trial.

BMC Cancer 2019 Nov 14;19(1):1110. Epub 2019 Nov 14.

Department of Radiation Oncology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066, CX, Amsterdam, The Netherlands.

Background: The majority of patients with head and neck squamous cell carcinoma (HNSCC) receive bilateral elective nodal irradiation (ENI), in order to reduce the risk of regional failure. Bilateral ENI, as compared to unilateral ENI, is associated with higher incidence of acute and late radiation-induced toxicity with subsequent deterioration of quality of life. Increasing evidence that the incidence of contralateral regional failure (cRF) in lateralized HNSCC is very low (< 10%) suggests that it can be justified to treat selected patients unilaterally. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12885-019-6331-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857144PMC
November 2019

Recurrence and survival rates in node negative patients after sentinel node biopsy for early-stage vulva cancer - A nationwide study.

Gynecol Oncol 2020 01 9;156(1):124-130. Epub 2019 Nov 9.

Department of Gynecology, Copenhagen University Hospital Rigshospitalet, Denmark.

Objective: The sentinel node (SN) procedure is adopted in selected patients with early-stage vulva cancer (VC) in Denmark. Due to the low incidence of VC, large population-based studies on the safety of SN outside multicenter clinical trials are lacking. The current study evaluated the risk of recurrence and survival in SN- negative VC patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ygyno.2019.10.024DOI Listing
January 2020

Diagnostic utility of touch imprint cytology for intraoperative assessment of surgical margins and sentinel lymph nodes in oral squamous cell carcinoma patients using four different cytological stains.

Diagn Cytopathol 2020 Feb 1;48(2):101-110. Epub 2019 Nov 1.

Department of Oral and Maxillofacial Pathology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, SIMATS, Chennai, India.

Background: OSCC is most commonly associated with positive surgical margins. The important cause of loco regional recurrence is histologically positive or closed margins. Clear surgical margins might favor the patient with a better prognosis and prevent repetitive surgeries. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/dc.24329DOI Listing
February 2020

Diagnostic precision of sentinel lymph node biopsy in penile cancer.

Indian J Urol 2019 Oct-Dec;35(4):282-286

Department of Urology, Instituto Nacional de Cancerología, Bogotá, Colombia.

Introduction: Sentinel lymph node biopsy (SLNB) was designed as a minimally invasive method for evaluation of nodal involvement in patients with penile cancer and nonpalpable lymph nodes. Nevertheless, SLNB is not used in a regular basis due to the lack of studies that adequately characterize the performance of this procedure. The purpose of this study was to evaluate the diagnostic performance of SLNB in patients with infiltrative penile carcinoma without palpable inguinal lymph nodes in a Colombian population. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/iju.IJU_79_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6792417PMC
October 2019
1 Read

[Sentinel lymph node biopsy in head and neck oncology].

Bull Cancer 2020 Jun 11;107(6):653-659. Epub 2019 Oct 11.

Université Paris-Saclay, département de cancérologie cervico-faciale, Gustave Roussy, 94805 Villejuif, France.

Sentinel lymph node biopsy (SLNB) has been initially developed for melanoma and breast cancers. Its application in head and neck cancers is recent, probably due to the complexity of the lymphatic drainage, the proximity between the primary tumor and the lymph nodes and the critical anatomical structures (such as the facial nerve). In onco-dermatology, SLNB is validated in head and neck surgery for melanoma with Breslow thickness up to 1mm or ulceration, Merkel carcinoma and high-risk squamous cell carcinoma. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bulcan.2019.06.014DOI Listing
June 2020
1 Read

Impact of Gene Expression Profile Testing on the Management of Squamous Cell Carcinoma by Dermatologists

J Drugs Dermatol 2019 Oct;18(10):980-984

Background: The incidence of cutaneous squamous cell carcinoma (cSCC) is increasing likely due to improved detection and a growing elderly population. Although the prognosis of cSCC is excellent with complete surgical excision, many patients who go on to develop metastasis are initially classified as low-risk. The most commonly used staging systems, American Joint Committee on Cancer (AJCC) and Brigham Women's Hospital (BWH), have low sensitivity and low positive predictive value for predicting metastasis. Read More

View Article

Download full-text PDF

Source
October 2019
3 Reads

Sentinel Node Biopsy in 105 High-Risk Cutaneous SCCs of the Head and Neck: Results of a Multicenter Prospective Study.

Ann Surg Oncol 2019 Dec 3;26(13):4481-4488. Epub 2019 Oct 3.

Sydney Head and Neck Cancer Institute, Chris O'Brien Lifehouse, Sydney, Australia.

Background: Regional nodal metastases from cutaneous squamous cell carcinoma (cSCC) is strongly associated with a poor prognosis, but these metastases are difficult to predict clinically. Sentinel node biopsy (SNB) has been used for a wide range of malignancies to assess for regional nodal metastasis, but is not widely used for cSCC.

Methods: Patients presenting with high-risk cSCC of the head and neck with clinically N0 necks were offered SNB at the time of primary cSCC excision or secondary wide local excision. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1245/s10434-019-07865-zDOI Listing
December 2019
2 Reads

Setting the stage: Contemporary staging of non-melanomatous skin cancer and implementation of the new American Joint Committee on cancer eighth edition staging manual.

Oral Oncol 2019 11 28;98:102-108. Epub 2019 Sep 28.

Department of Radiation Oncology, Peter MacCallum Cancer Centre, 305 Grattan Street, Melbourne, Victoria, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Victoria, Australia. Electronic address:

Non-melanomatous skin cancer (NMSC) generally refers to basal cell and squamous cell carcinoma of the skin. The majority of patients are curatively treated with simple excision. Only few present with locally advanced disease or have evidence of high-risk features, placing them at an elevated risk of relapse. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.oraloncology.2019.09.020DOI Listing
November 2019
1 Read
3.607 Impact Factor

Effectiveness of sentinel lymph node scintigraphy and intraoperative gamma probing with gold standard elective neck dissection in patients with N0 oral squamous cell cancers.

Nucl Med Commun 2019 Nov;40(11):1138-1147

Objective: Oral cancer ranks in the top three of all cancers in India, accounting for over 30% of all cancers reported. Elective neck dissection (END) is the mainstay of treatment in early disease. Performing ENDs for node negative (N0) patients can result in significant morbidity with questionable benefit and impair the patients' quality of life. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MNM.0000000000001090DOI Listing
November 2019
3 Reads

Predictive Value of Sentinel Lymph Node Biopsy in Cutaneous Squamous Cell Carcinoma Based on the AJCC-8 and Brigham and Women's Hospital Staging Criteria.

Dermatol Surg 2020 Jul;46(7):857-862

Servicio de Dermatología, Instituto Valenciano de Oncología Valencia, Spain.

Background: Recommendations on when to perform sentinel lymph node (SLN) biopsy in cutaneous squamous cell carcinoma (cSCC) are lacking despite the tumor's clear predilection for lymphatic spread.

Objective: To analyze the frequency of SLN metastasis in published series of cSCC in the context of the eighth edition of the American joint Committee on Cancer (AJCC-8) and the Brigham and Women's Hospital (BWH) staging criteria.

Methods: Systematic review of studies of patients with cSCC who underwent SLN biopsy that described biopsy results. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/DSS.0000000000002170DOI Listing
July 2020
8 Reads

Usefulness of real-time elastography for diagnosing lymph node metastasis of skin cancer: does elastography potentially eliminate the need for sentinel lymph node biopsy in squamous cell carcinoma?

J Eur Acad Dermatol Venereol 2020 Apr 12;34(4):754-761. Epub 2019 Nov 12.

Department of Dermatology, Teikyo University School of Medicine, Tokyo, Japan.

Background: The metastatic involvement of regional lymph nodes is the most important prognostic factor for overall survival of skin cancer patients. The sonographic technique of freehand real-time tissue elastography (RTE), which displays tissue rigidity as a colour overlay of the tissue image, was developed.

Objective: Our purpose was to evaluate the benefit of RTE for detecting lymph node metastases of skin cancer non-invasively before operation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jdv.15955DOI Listing
April 2020
2 Reads

Long term outcomes in patients with sentinel lymph nodes (SLNs) identified by injecting remaining scar after previously excised vulvar cancer.

Gynecol Oncol 2019 10 23;155(1):83-87. Epub 2019 Aug 23.

University of Toronto, Division of Gynecologic Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada. Electronic address:

Background: Lymph node metastasis is the most important prognostic factor in patients with vulvar squamous cell carcinoma (SCC). Previous excision of the vulvar tumor may disrupt lymphatic channels and alter the accuracy of the sentinel lymph node (SLN) biopsy. The purpose of this study was to measure outcomes after SLN biopsy in patients with and without previous excision of the vulvar tumor. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ygyno.2019.08.015DOI Listing
October 2019
2 Reads

Clinical management of early-stage cervical cancer: The role of sentinel lymph node biopsy in tumors ≤2 cm.

Eur J Obstet Gynecol Reprod Biol 2019 Oct 7;241:30-34. Epub 2019 Aug 7.

Department of Gynecology, Vall d'Hebron University Hospital, Universitat Autònoma de Barcelona, 08035 Barcelona, Spain.

Objective: To evaluate the experience with sentinel lymph node (SLN) biopsy in patients with early-stage cervical cancer at our hospital, and to analyze factors influencing the rate of false negatives.

Study Design: This study was carried out at the Vall d'Hebron Hospital (Barcelona, Spain) between September 2000 and October 2016. All patients underwent SLN biopsy and systematic and bilateral pelvic lymphadenectomy, followed by radical hysterectomy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejogrb.2019.07.038DOI Listing
October 2019

Cutaneous Squamous Cell Carcinoma Tumour Size is Associated with Sentinel Lymph Node Metastasis in a Cohort of 69 Patients.

Acta Derm Venereol 2019 Dec;99(13):1241-1245

Department of ENT-Head and Neck Surgery, University Cancer Institute Toulouse and Toulouse University Hospital, Hôpital Larrey, FR-31400 Toulouse, France.

Ten to fifty percent of high-risk cutaneous squamous cell carcinoma may potentially metastasize. However, the concept of sentinel lymph node biopsy remains controversial for cutaneous squamous cell carcinoma. The aim of this study was to identify prognostic factors associated with sentinel lymph node positivity. Read More

View Article

Download full-text PDF

Source
http://www.medicaljournals.se/acta/content/abstract/10.2340/
Publisher Site
http://dx.doi.org/10.2340/00015555-3293DOI Listing
December 2019
4 Reads

Sentinel ode apping in on-small ell ung ancer sing an ntraoperative adiotracer echnique.

Asia Ocean J Nucl Med Biol 2019 ;7(2):153-159

Lung Disease Research Center, Faculty of Medicine, Mashhad University of Medicine Sciences, Mashhad, Iran.

Objectives: Lymph node metastases are the most significant prognostic factor in localized non-small cell lung cancer (NSCLC). Identification of the first nodal drainage site (sentinel node) may improve detection of metastatic nodes. Extended surgeries, such as lobectomy or pneumonectomy with lymph node dissection, are among the therapeutic options of higher acceptability. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.22038/AOJNMB.2019.13195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6661315PMC
January 2019
3 Reads

Outcome of sentinel lymph node biopsy in early-stage squamous cell carcinoma of the oral cavity with methylene blue dye alone: a prospective validation study.

Br J Oral Maxillofac Surg 2019 10 11;57(8):755-759. Epub 2019 Jul 11.

Department of Radiotherapy, All India Institute of Medical Sciences, Jodhpur, India.

Our aim was to evaluate the feasibility and role of sentinel lymph node (SLN) biopsy using methylene blue dye alone in identifying occult lymph node metastases in early oral cancer (cT1, T2, and cN0). The study was done from 2013-15 in 94 patients in a large cancer centre. The blue nodes were dissected and sent for frozen section, routine histopathological examination, and immunohistochemical testing for cytokeratin, and was followed by elective neck dissection in all patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bjoms.2019.06.025DOI Listing
October 2019
72 Reads
1 Citation
1.133 Impact Factor

Surgical treatment of vulvar cancer: Impact of tumor-free margin distance on recurrence and survival. A multicentre cohort analysis from the francogyn study group.

Eur J Surg Oncol 2019 Nov 3;45(11):2109-2114. Epub 2019 Jul 3.

Department of Obstetrics and Gynaecology, Institute Alix de Champagne University Hospital, Reims, France.

Objective: In vulvar cancer, it is admitted that tumor-free margin distance is one of the most important element for locoregional control. It is currently recommended to surgically remove the tumor with at least an 8 mm tumor-free margin. The aim of this study was to evaluate the impact of tumor-free margin distance on recurrence and survival in vulvar cancer. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejso.2019.07.005DOI Listing
November 2019

Sentinel Lymph Node Biopsy Using Preoperative Computed Tomographic Lymphography and Intraoperative Indocyanine Green Fluorescence Imaging in Patients With Localized Tongue Cancer.

JAMA Otolaryngol Head Neck Surg 2019 Jun 27. Epub 2019 Jun 27.

Department of Otolaryngology-Head and Neck Surgery, Niigata University Graduate School of Medical and Dental Sciences, Akita, Japan.

Importance: The indocyanine green method alone is unsuitable for sentinel lymph node biopsy in patients with oral cancer because of poor transcutaneous identification of the fluorescent signal through the platysma and sternocleidomastoid muscles.

Objective: To assess the utility of a novel sentinel lymph node biopsy technique using preoperative computed tomographic (CT) lymphography followed by the intraoperative indocyanine green fluorescence method.

Design, Setting, And Participants: In this prospective study performed at Akita University Hospital, Akita, Japan, participants comprised 18 patients with previously untreated cN0 tongue cancer (squamous cell carcinoma) were enrolled from November 2012 to November 2016. Read More

View Article

Download full-text PDF

Source
https://jamanetwork.com/journals/jamaotolaryngology/fullarti
Publisher Site
http://dx.doi.org/10.1001/jamaoto.2019.1243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6604111PMC
June 2019
8 Reads

Health-related quality of life in patients with T1N0 oral squamous cell carcinoma: selective neck dissection compared with wait and watch surveillance.

Br J Oral Maxillofac Surg 2019 09 21;57(7):649-654. Epub 2019 Jun 21.

Evidence-Based Practice Research Centre (EPRC), Faculty of Health and Social Care, Edge Hill University, St. Helens Road, Ormskirk, L39 4QP; Consultant Regional Maxillofacial Unit, University Hospital Aintree, Liverpool, L9 1AE, UK. Electronic address:

Management of the neck in patients with clinical T1N0 oral squamous cell carcinoma (SCC) is controversial. The aim of this study was to report the health-related quality of life (HRQoL) in a consecutive group of patients with stage 1 disease at a time closest to two years after primary surgery. Of 216 patients treated between 2007 and 2012 (after excluding early death and regional recurrence), 195 were eligible. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bjoms.2019.05.021DOI Listing
September 2019
17 Reads

Augmenting camera images with gamma detector data : A novel approach to support sentinel lymph node biopsy.

EJNMMI Phys 2019 Jun 18;6(1):10. Epub 2019 Jun 18.

Department of Biomedical Engineering, University of Basel, Allschwil, CH-4123, Switzerland.

Background: Squamous cell carcinoma in the head and neck region is one of the most widespread cancers with high morbidity. Classic treatment comprises the complete removal of the lymphatics together with the cancerous tissue. Recent studies have shown that such interventions are only required in 30% of the patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40658-019-0245-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6582166PMC
June 2019
13 Reads

Skin Cancer: Squamous and Basal Cell Carcinomas.

FP Essent 2019 Jun;481:17-22

Approximately 1 in 5 Americans will develop skin cancer during their lifetime; 97% of these cancers will be nonmelanoma skin cancers (NMSCs). Basal cell carcinoma (BCC) comprises approximately 80% of NMSCs and most of the remainder are cutaneous squamous cell carcinomas (SCCs). The predominant risk factor for NMSC is exposure to solar UV radiation. Read More

View Article

Download full-text PDF

Source
June 2019
20 Reads

Ultrasound-guided FNA cytology of groin lymph nodes improves the management of squamous cell carcinoma of the vulva: Results from a comparative cytohistological study.

Cancer Cytopathol 2019 Aug 7;127(8):514-520. Epub 2019 Jun 7.

Department of Woman and Child Health and Public Health, Pathology Area, Agostino Gemelli University Hospital Foundation, Scientific Institute for Research and Healthcare, Rome, Italy.

Background: Lymph node metastases represent the most important negative prognostic predictor in vulvar carcinoma. Therefore, an accurate preoperative assessment of suspicious lymph nodes would be fundamental for a personalized therapy. The aim of this article was to assess the reliability of ultrasound-guided fine-needle aspiration cytology (FNAC) in the preoperative assessment of nodal metastatic disease in 43 patients with vulvar cancer. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cncy.22154DOI Listing
August 2019
7 Reads

Predictive factors for late cervical metastasis in stage I and II squamous cell carcinoma of the lip.

Eur Arch Otorhinolaryngol 2019 Jul 4;276(7):2047-2053. Epub 2019 Jun 4.

Department of Head and Neck Surgery of Hospital das Clínicas, University of São Paulo School of Medicine, Av. Dr. Enéas de Carvalho Aguiar, 255, São Paulo/SP, CEP 05403-000, Brazil.

Purpose: Many authors have described clinicopathologic parameters as factors related to cervical lymph node metastasis development in N0 stage lip cancer. However, predictive factors for occult lymph node metastasis and criteria for elective neck dissection, especially for early tumour, remain undefined.

Methods: A multi-institutional study with 193 consecutive patients with early lip SCC treated from January 1990 to March 2006 was carried out retrospectively to determine factors predicting occult metastasis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00405-019-05457-xDOI Listing
July 2019
19 Reads

Sentinel lymph node biopsy for management of the N0 neck in oral cavity squamous cell carcinoma.

J Surg Oncol 2019 Aug 16;120(2):101-108. Epub 2019 May 16.

Department of Head and Neck and Plastic Surgery, Erie County Medical Center, SUNY Buffalo, Buffalo, New York.

Background And Objectives: The management of the clinically N0 (cN0) neck is controversial for early stage squamous cell carcinoma of the oral cavity (OSCC). This paper represents a single institution series analyzing the efficacy of sentinel lymph node biopsy (SNB) for early stage oral cavity cancers.

Methods: From 2005 to 2017, 108 patients with cN0 OSCC were treated with primary resection and SNB. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jso.25494DOI Listing
August 2019
11 Reads

Management of Skin Cancer in the Elderly.

Dermatol Clin 2019 Jul;37(3):279-286

Division of Dermatology, Cooper University Hospital, 10000 Sagemore Drive #10103, Marlton, NJ 08053, USA. Electronic address:

Over the next 30 years, dermatologists face a rising population of elderly patients, causing a marked increase in the incidence of cutaneous malignancies. For this reason, it is important to review the approach to the management of skin cancer in the elderly. In the current medical environment, there has been debate as to how cutaneous malignancy should be treated in elderly patients, especially those with multiple comorbid conditions. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S07338635193001
Publisher Site
http://dx.doi.org/10.1016/j.det.2019.02.003DOI Listing
July 2019
15 Reads

Organ-sparing surgery of penile cancer: higher rate of local recurrence yet no impact on overall survival.

World J Urol 2020 Feb 6;38(2):417-424. Epub 2019 May 6.

Department of Urology, Medical University Innsbruck, Anichstraße 35, 6020, Innsbruck, Austria.

Purpose: To report on the oncological outcome of organ-sparing surgery (OSS) compared to (total or partial) penectomy regarding recurrence patterns and survival in squamous cell carcinoma (SCC) of the penis.

Methods: This was a retrospective study of all patients with penile SCC and eligible follow-up data of at least 2 years at our institution. Patients with tumors staged ≥ pT1G2 underwent invasive lymph node (LN) staging by dynamic sentinel-node biopsy or modified inguinal lymphadenectomy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00345-019-02793-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6994547PMC
February 2020
9 Reads

Corrigendum to: Squamous cell carcinoma of the anal canal: a review of the aetiology, presentation, staging, prognosis and methods available for treatment.

Sex Health 2018 11;15(5):480

Anal cancer is an uncommon malignancy, with the majority of cases comprised of squamous cell carcinomas. The increasing incidence of this disease reflects a rise in the transmission of the human papillomavirus, the causative organism of most tumours. Abdominoperineal resection (APR), once the primary mode of treatment, has been supplanted by sphincter-saving combination chemoradiation as the first-line therapy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1071/SH12010_CODOI Listing
November 2018
7 Reads

Cost-Effectiveness of Sentinel Lymph Node Biopsy for Head and Neck Cutaneous Squamous Cell Carcinoma.

J Surg Res 2019 09 17;241:15-23. Epub 2019 Apr 17.

Division of Surgical Oncology, Department of Surgery, Rutgers New Jersey Medical School, Newark, New Jersey. Electronic address:

Background: Sentinel lymph node biopsy (SLNB) has shown promise in identifying subclinical nodal metastasis in patients with high-risk cutaneous squamous cell carcinoma. However, low metastasis rates may indicate that performing such a procedure in all patients may be unnecessary and costly.

Materials And Methods: A decision model was developed to analyze costs and survival in patients with head and neck cutaneous squamous cell carcinoma based on their tumor and nodal metastasis staging and whether or not they received an SLNB. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jss.2019.03.040DOI Listing
September 2019
11 Reads

Robot-assisted Sentinel Lymph Node Mapping and Inguinal Lymph Node Dissection Using Near-infrared Fluorescence in Vulvar Cancer.

J Minim Invasive Gynecol 2019 Jul - Aug;26(5):968-972. Epub 2019 Apr 6.

Department of Obstetrics and Gynecology, University of Missouri, Columbia, MO (all authors).. Electronic address:

The surgical treatment of vulvar cancer has undergone many changes over the last century. The morbidity of open inguinal incisions prompts the search for a minimally invasive approach to lymph node dissection. This study reports the outcomes of 4 patients with vulvar cancer undergoing robotic sentinel lymph node (SLN) mapping and lymph node (LN) dissection with near-infrared fluorescence. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jmig.2019.04.002DOI Listing
December 2019
27 Reads

Predictive factors of severe perioperative morbidity of radical hysterectomy with lymphadenectomy in early-stage cervical cancer: A French prospective multicentric cohort of 248 patients.

Eur J Surg Oncol 2019 04 17;45(4):650-658. Epub 2018 Oct 17.

Gynecologic and Breast Oncologic Surgery Department, Georges Pompidou European, Hospital, Paris, France; Paris Descartes University, Sorbonne Paris Cité, Faculty of Medicine, Paris, France.

Objective: The purpose of this study was to assess the postoperative morbidity after radical hysterectomy (RH) for early-stage cervical cancer and to determine risk factors of severe perioperative morbidity.

Methods: Data of two prospective trials on sentinel node biopsy for cervical cancer (SENTICOL I & II) were analysed. Patients having a radical hysterectomy were included between 2005 and 2012 from 25 French oncologic centers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejso.2018.10.057DOI Listing
April 2019
10 Reads

SENTICOL III: an international validation study of sentinel node biopsy in early cervical cancer. A GINECO, ENGOT, GCIG and multicenter study.

Int J Gynecol Cancer 2019 05 20;29(4):829-834. Epub 2019 Mar 20.

Gynecologic Oncology, CCTG, Fondation du CHU de Quebec, Quebec City, Quebec, Canada.

Background: Radical hysterectomy and complete pelvic lymphadenectomies are the most commonly performed procedures for women with early-stage cervical cancer. Sentinel lymph node (SLN) mapping could be an alternative to routine pelvic lymphadenectomy, aiming to diagnose accurately nodal extension and decrease lymphatic morbidity.

Primary Objective: To compare 3-year disease-free survival and health-related quality of life after SLN biopsy or SLN biopsy + pelvic lymphadenectomy in early cervical cancer. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/ijgc-2019-000332DOI Listing
May 2019
36 Reads

Perioperative morbidity of radical trachelectomy with lymphadenectomy in early-stage cervical cancer: a French prospective multicentric cohort.

J Gynecol Oncol 2019 May;30(3):e34

Gynecology Department, University Hospital, University of Lausanne, Lausanne, Switzerland.

Objective: The aim of this study was to determine the predictive factors of postoperative morbidity of patients who have undergone a radical trachelectomy (RT) for early-stage cervical cancer and to assess the oncologic outcomes.

Methods: We retrospectively analysed the data of 2 prospective trials on sentinel node biopsy for cervical cancer (SENTICOL I and II). Patients having a RT for early-stage cervical cancer with negative sentinel lymph node and safe margins, were included. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3802/jgo.2019.30.e34DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424838PMC
May 2019
13 Reads