811 results match your criteria Sentinel Lymph Node Biopsy in Patients With Squamous Cell Carcinoma


Tilmanocept as a novel tracer for lymphatic mapping and sentinel lymph node biopsy in melanoma and oral cancer.

ANZ J Surg 2022 Jul 18. Epub 2022 Jul 18.

Faculty of Medicine, Department of Surgical Oncology and Head and Neck Surgery, Crown Princess Mary Cancer Centre, University of Sydney, Sydney, New South Wales, Australia.

Background: Sentinel lymph node biopsy (SLNB) has been pivotal for pathological assessment of nodal status in cutaneous melanoma (CM) and oral cavity squamous cell carcinoma (OCSCC) thus crucial for staging. An ideal agent for lymphatic mapping should have a standardized preparation, appropriate accumulation in first-echelon nodes and no side effects. Tilmanocept, a CD206-receptor targeted novel radiotracer fulfils these properties. Read More

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In-transit metastasis of cutaneous squamous cell carcinoma: report of two cases.

Acta Dermatovenerol Alp Pannonica Adriat 2022 Jun;31(2):75-77

Department of Dermatology and Venereology, Haydarpaşa Numune Training and Research Hospital, Istanbul, Turkey.

Transit metastases include metastatic foci of the skin and subcutaneous tissue located between the tumor and the nearest regional lymph node. Although transit metastases have been described for malignant melanoma, some cases of transit metastases have also been reported among primary cutaneous non-melanoma cancers. Treatment of patients with in-transit squamous cell carcinoma (SCC) is a multimodal approach for advanced staging imaging and therapy, including Mohs micrographic surgery, adjuvant radiation, and possibly sentinel lymph node biopsy and immunotherapy or chemotherapy. Read More

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Sentinel lymph node biopsy in high-risk cutaneous squamous cell carcinoma of the head and neck: Systematic review and meta-analysis.

Head Neck 2022 Jun 17. Epub 2022 Jun 17.

Department of Biomedical Sciences, Humanitas University, Pieve Emanuele (MI), Italy.

The aim of our study was to better define the role of sentinel lymph node biopsy (SLNB) in high-risk cutaneous squamous cell carcinoma of the head and neck (cSCCHN). A systematic review and meta-analysis was performed according to the PRISMA statement. Seven-hundred and five patients were included from 20 studies. Read More

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Interrogating the Impassable: A Case Series and Literature Review of Unilateral SPECT-CT Groin Visualization in Men With Penile Cancer.

Front Surg 2022 18;9:882011. Epub 2022 May 18.

Division of Cancer Surgery, Peter MacCallum Cancer Center, Melbourne, VIC, Australia.

Penile squamous cell carcinoma (SCC) is a rare malignancy, which is known to invade local inguinal lymph nodes prior to progressing to the pelvis. Dynamic sentinel lymph node biopsy (DSLNB) is a standard for the minimally invasive assessment of lymphadenopathy in patients with subclinical groin metastasis. Hybrid Tc Single-Photon Emission Computed Tomography (SPECT-CT) has been shown to increase the accuracy of identifying first draining "sentinel" nodes (SN). Read More

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Pattern of cervical lymph node metastases in squamous cell carcinoma of the upper oral cavity - How to manage the neck.

Oral Oncol 2022 07 13;130:105898. Epub 2022 May 13.

Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Oral and Maxillofacial Surgery, Augustenburger Platz 1, 13353 Berlin, Germany.

Objectives: Oral squamous cell carcinoma (OSCC) arising from the upper oral cavity is rare compared to other localizations. While cervical lymph node metastasis (CLNM) can be predicted to some extent, the probability of occult CLNM remains high. The aim of this study is to determine risk factors affecting clinical decision making. Read More

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High-risk cutaneous squamous cell carcinoma (CSCC): Challenges and emerging therapies.

Asian J Surg 2022 May 8. Epub 2022 May 8.

Reconstructive Sciences Unit, School of Medical Sciences, Universiti Sains Malaysia, 16150, Kota Bharu, Malaysia; Hospital Universiti Sains Malaysia, 16150, Kubang Kerian, Kelantan, Malaysia. Electronic address:

Cutaneous squamous cell carcinoma (CSCC) is a common type of skin malignancy that affects people who have been exposed to sunlight for a long time. It has been associated to a high mutational load, making treatment problematic, especially for individuals with high-risk CSCC characteristics. Patients with high-risk CSCC are difficult to define since definitions are still imprecise. Read More

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Advantages of Sentinel Lymph Node Mapping by Single Photon Emission Computed Tomography/Computed Tomography in Early-Stage Malignant Head-and-Neck Skin Tumors.

Indian J Nucl Med 2022 Jan-Mar;37(1):43-49. Epub 2022 Mar 25.

Department of Epidemiology, National Cancer Institute, Bogotá, Colombia.

Background: The aim of this study was to determine the advantages of preoperative sentinel lymph node mapping (SLNM) by single photon emission computed tomography/computed tomography (SPECT / CT) in patients with early-stage cutaneous head-and-neck malignancies.

Materials And Methods: We conduct a 7-year and 6 months retrospective, cross-sectional study. Patients with early-stage malignant head-and-neck skin tumors and cutaneous adnexa who underwent SLNM by SPECT/CT from March 2012 and December 2019, were included in the study. Read More

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Survival in node-positive early oral squamous cell carcinoma: sentinel node biopsy versus elective neck dissection.

Br J Oral Maxillofac Surg 2022 Mar 9. Epub 2022 Mar 9.

Greater Glasgow & Clyde Health Board, United Kingdom.

Patients undergoing sentinel node biopsy (SLNB) for early oral squamous cell carcinoma (OSCC) who harbour occult metastases (pN+ve) may be at greater risk of mortality due to prolonged overall treatment times than those identified as pN+ve on elective neck dissection (ELND). A retrospective comparative survival analysis was therefore undertaken to test this hypothesis. Patients were identified from the South Glasgow multidisciplinary team (MDT) database. Read More

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Sentinel lymph node procedure in patients with recurrent vulvar squamous cell carcinoma: a proposed protocol for a multicentre observational study.

BMC Cancer 2022 Apr 23;22(1):445. Epub 2022 Apr 23.

Department of Gynaecologic Oncology, Erasmus MC Cancer Institute, University Medical Center Rotterdam, P.O. Box 2040, 3000, CA, Rotterdam, The Netherlands.

Background: Standard groin treatment in recurrent vulvar cancer consists of uni- or bilateral inguinofemoral lymphadenectomy (IFL), whereas in the primary setting women with selected unifocal tumours will undergo a sentinel lymph node (SLN) procedure. The SLN procedure results in fewer short and long-term sequelae compared to IFL, but some concerns must first be considered. Lymph drainage of the vulvar region can be affected by a previous surgery, which might reduce the number of detectable SLN nodes (feasibility) but increase the chance of encountering aberrant lymph drainage patterns such as bilateral SLNs in lateral tumours or SLNs at unexpected locations. Read More

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Identification of occult metastatic disease via lymphoscintigraphy-guided neck dissection in N0 oral squamous cell carcinoma.

Head Neck 2022 07 16;44(7):1596-1603. Epub 2022 Apr 16.

Department of Otolaryngology - Head and Neck Surgery, Weill Cornell Medical College, New York, New York, USA.

Background: The purpose of this study is to assess the efficacy of lymphoscintigraphy-guided neck dissection (LSG-ND) in the treatment of N0 oral squamous cell carcinoma.

Methods: A retrospective cohort study of patients with N0 oral squamous cell carcinoma (SCC) who had either LSG-ND or neck dissection (ND) at our institution between 2008 and 2020.

Results: Eighty-seven patients met criteria with N0 oral squamous cell carcinoma with no previous treatment or neck surgery (27 LSG-ND, 60 ND). Read More

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Sentinel lymph node biopsy for early squamous cell carcinoma of the lip and oral cavity: Real-world experience in Brazil.

Head Neck 2022 07 15;44(7):1604-1615. Epub 2022 Apr 15.

Department of Head and Neck Surgery and Otolaryngology, A C Camargo Cancer Center, São Paulo, Brazil.

Background: This study aimed to evaluate the accuracy and oncological results of sentinel lymph node biopsy in patients with early lip and oral cavity squamous cell carcinoma (SCC) in a real-world scenario.

Methods: Retrospective study including seven Brazilian centers.

Results: Four-hundred and seven cN0 patients were accrued for 20 years. Read More

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Efficacy of different sentinel lymph node biopsy protocols in oral squamous cell carcinoma: Systematic review and meta-analysis.

Head Neck 2022 07 31;44(7):1702-1714. Epub 2022 Mar 31.

Oral Medicine and Surgery Unit, Faculty of dentistry, Universidade de Santiago de Compostela, Santiago de Compostela, Spain.

The sentinel node biopsy (SNB) is highly protocolized in other cancers, however, this is not the case for oral squamous cell carcinoma patients, hence our objective was to evaluate the different protocols published. A specific study protocol was designed and subsequently registered on PROSPERO (Ref. CRD42021279217). Read More

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Sentinel lymph node biopsy for early oral cancer - accuracy and considerations in patient selection.

Br J Oral Maxillofac Surg 2022 07 12;60(6):830-836. Epub 2022 Jan 12.

Department of Pathology, Queen Elizabeth University Hospital, 1345 Govan Road, Glasgow G51 4TF, UK.

Sentinel lymph node biopsy (SLNB) for staging oral squamous cell carcinoma (OSCC) patients presenting with early (T1 and T2 N0) disease in preference to elective neck dissection (END) remains controversial worldwide. A retrospective analysis of 145 patients who underwent sentinel lymph node biopsy for a previously untreated early oral cancer between 2010 and 2020 was performed. The primary outcome measures were predictors of occult metastases, accuracy of SLNB and disease specific plus overall survival. Read More

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Does Sentinel Lymph Node Biopsy Accurately Stage the Clinically Negative Neck in Early Oral Cavity Squamous Cell Carcinoma?

J Oral Maxillofac Surg 2022 06 18;80(6):1134-1142. Epub 2022 Feb 18.

Associate Professor, Head and Neck Cancer Service, Crown Princess Mary Cancer Centre, Westmead Hospital, Sydney, New South Wales, Australia; Associate Professor, Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia.

Purpose: Sentinel lymph node biopsy (SLNB) is being increasingly used worldwide as a minimally invasive option to stage the clinically node-negative neck (N0) in patients with early oral cavity squamous cell carcinomas (OCSCC). We performed this trial to assess the reliability and validity of the technique.

Methods: We did this prospective interventional nonrandomized study in patients with early (cT1-T2 OCSCC) and with negative neck. Read More

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Sentinel lymph node biopsy for head and neck cutaneous squamous cell carcinoma using the Brigham and Women's staging system: a cost analysis.

Arch Dermatol Res 2022 Mar 18. Epub 2022 Mar 18.

Division of Surgical Oncology, Department of Surgery, Rutgers New Jersey Medical School, 205 South Orange Ave, F1222, Newark, NJ, 07103, USA.

The objective is to determine the cost-effectiveness of sentinel lymph node biopsy (SLNB) for cutaneous squamous cell carcinoma (CSCC) according to the Brigham and Women's Hospital (BWH) Tumor Staging system. A decision analysis was utilized to examine costs and outcomes associated with the use of SLNB in patients with high-risk head and neck CSCC. Decision tree outcome probabilities were obtained from published literature. Read More

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Dynamic Sentinel Lymph Node Biopsy for Penile Cancer: Accuracy is in the Technique.

Urology 2022 Jun 11;164:e308. Epub 2022 Mar 11.

Division of Cancer Surgery, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia; Department of Urology, The Royal Melbourne Hospital, Melbourne, Victoria, Australia; EJ Whitten Prostate Cancer Research Centre at Epworth Healthcare, Melbourne, Australia. Electronic address:

Objectives: To demonstrate an operative standard for dynamic sentinel lymph node biopsy (DSLNB). Long-term survival in men with penile squamous cell carcinoma (SCC) depends on accurately staging lymph node metastases. European Association of Urology (EAU) and National Comprehensive Cancer Network (NCCN) guidelines recognize DSLNB as a standard for staging men with intermediate to high-risk tumors and clinically absent inguinal lymphadenopathy. Read More

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Inverted urethral flap reconstruction after partial penectomy: Long-term oncological and functional outcomes.

Urol Oncol 2022 04 6;40(4):169.e13-169.e20. Epub 2022 Mar 6.

Department of Urologic Oncology, Instituto Nacional de Cancerología, Bogotá, Colombia.

Introduction: Penile aesthetics after partial penectomy (PP) for penile cancer (PC), significantly affect a patient's health-related quality of life (HRQoL), self-esteem, and sexual function. Satisfactory reconstruction has become a major milestone in the treatment of these patients.

Methods: Clinical charts of all patients that underwent PP and reconstruction with an inverted urethral flap (IUF) were reviewed. Read More

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Centralised pathology service for sentinel node biopsy in oral cavity cancer: The Southeast England Consortium experience.

J Oral Pathol Med 2022 Apr 7;51(4):315-321. Epub 2022 Mar 7.

Head and Neck Academic Centre, University College London, London, UK.

Background: Sentinel lymph node biopsy is an increasingly recognised option for accurate staging and subsequent management of the clinically negative neck in early stage oral cavity squamous cell carcinoma. However, the technique is currently underused due to several logistic constraints including increased burden on pathology services. Here, we describe the feasibility of an outsourced centralised pathology processing and reporting service for sentinel lymph node biopsies in oral cavity squamous cell carcinoma. Read More

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Incorporation of sentinel lymph node biopsy in cervical cancer surgery: Recent U.S. trends.

Eur J Surg Oncol 2022 Jun 18;48(6):1407-1413. Epub 2022 Feb 18.

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Columbia University College of Physicians and Surgeons, New York, NY, USA.

Objective: To examine the trends, characteristics, and outcomes related to sentinel lymph node (SLN) biopsy for cervical cancer surgery.

Methods: This retrospective cohort study queried the National Cancer Institute's Surveillance, Epidemiology, and End Results Program. Study population included patients with invasive cervical cancer (squamous cell carcinoma, adenocarcinoma, and adenosquamous carcinoma) who underwent both hysterectomy and lymphadenectomy for T1 classification from 2003 to 2018. Read More

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In-Transit Metastasis of Cutaneous Squamous Cell Carcinoma With Lymphovascular Invasion in an Immunocompetent Patient.

Cureus 2022 Jan 13;14(1):e21204. Epub 2022 Jan 13.

Dermatology, Mayo Clinic, Rochester, USA.

In-transit metastases of melanoma and non-melanoma skin cancers are metastases located in the skin or subcutaneous tissue between the primary tumor and the nearest nodal basin. Although rare, in-transit cutaneous squamous cell carcinoma (SCC) is an emerging diagnosis in immunocompromised and immunocompetent patients that may have significant implications on treatment and prognosis. Lymphovascular invasion is an uncommon high-risk feature of SCC. Read More

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January 2022

A large multicenter propensity match study of sentinel lymph node biopsy feasibility in endometrioid variants of endometrial cancer.

Eur J Surg Oncol 2022 Jun 31;48(6):1390-1394. Epub 2022 Jan 31.

Dipartimento per le Scienze della Salute della Donna e del Bambino, Fondazione Policlinico Universitario A. Gemelli IRCCS, Department of Gynecology and Obstetrics, Roma, Italy.

Introduction: Sentinel lymph node (SLN) biopsy algorithm has been routinely applied in all endometrial endometrioid tumors, however, no studies analyzed the feasibility of SLN mapping in endometrioid variants (EV), which included villoglandular, secretory, ciliated cell, mucinous, and squamous differentiation. This study aimed to demonstrate the feasibility of SLN biopsy in EV of EC.

Materials And Methods: All patients undergoing minimally invasive surgical treatment for early-stage EC were included in the study. Read More

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Detection of melanoma, breast cancer and head and neck squamous cell cancer sentinel lymph nodes by Tc-99m Tilmanocept (Lymphoseek®).

Authors:
Stanley P Leong

Clin Exp Metastasis 2022 02 28;39(1):39-50. Epub 2021 Dec 28.

California Pacific Medical Center and Research Institute, San Francisco, CA, USA.

Technetium-99m-labeled Tilmanocept or Lymphoseek® (Cardinal Health, Dublin, Ohio) is a soluble, synthetic molecule with a small diameter (7 nm), which is comprised of technetium-99m chelated to a dextran backbone containing multiple units of mannose ligands with a high affinity for CD206, a receptor located on the surface of macrophages and dendritic cells that are found in high concentration in lymph nodes. It enables quick transit from the injection site and rapid lymph node accumulation. The binding of mannose ligand and CD206 results in the internalization of the ligand and receptor into the cell. Read More

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February 2022

The giant steps in surgical downsizing toward a personalized treatment of vulvar cancer.

J Obstet Gynaecol Res 2022 Mar 28;48(3):533-540. Epub 2021 Dec 28.

Gynecologic Oncology Unit, Department of Experimental Clinical Oncology, IRCSS-Regina Elena National Cancer Unit Institute, Rome, Italy.

The present article aims to highlight the importance of changes of personalized surgical treatment for vulvar cancer. Current international literature regarding surgical treatment of vulvar cancer was evaluated. This included several studies and systematic reviews. Read More

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Clinical impact of low-volume lymph node metastases in early-stage cervical cancer: A comprehensive meta-analysis.

Gynecol Oncol 2022 02 20;164(2):446-454. Epub 2021 Dec 20.

Department of Gynecology and Obstetrics, CHUV Lausanne, Lausanne, Switzerland; Department of Gynecology and Obstetrics, FOCH Hospital, 92150 Suresnes, France.

Objective: In order to define the clinical significance of low-volume metastasis, a comprehensive meta-analysis of published data and individual data obtained from articles mentioning micrometastases (MIC) and isolated tumor cells (ITC) in cervical cancer was performed, with a follow up of at least 3 years.

Methods: We performed a systematic literature review and meta-analysis, following Cochrane's review methods guide and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The primary outcome was the disease-free survival (DFS), and the secondary outcome was the overall survival (OS). Read More

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February 2022

Patient Selection for Surgery vs Radiotherapy for Early Stage Oropharyngeal Cancer.

Cancer Control 2021 Jan-Dec;28:10732748211050770

Department of Radiation Oncology, 11238American University of Beirut, Beirut, Lebanon.

Surgery and radiation therapy are both commonly used in the treatment of early stage (AJCC stages T1-T2 N0-M0) oropharyngeal squamous cell carcinoma (OPSCC). Transoral robotic surgery (TORS) and intensity modulated radiation therapy (IMRT) have been reported to result in similar survival and disease control outcomes. However, their side effect profiles widely differ. Read More

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January 2022

Distribution pattern and pathologic analysis of metastatic sentinel and non-sentinel lymph nodes in lymphatic basin dissection for clinical T2/T3 oral cancer with clinical N0 status.

Auris Nasus Larynx 2022 Aug 9;49(4):680-689. Epub 2021 Dec 9.

Department of Otorhinolaryngology, Head and Neck Surgery, Asahi University Hospital, Mizuho, Gifu, Japan.

Objective: The localization pattern of metastatic sentinel lymph node (SN) and non-SNs and pathologic analysis of metastatic lymph nodes in SN lymphatic basin dissection (SLBD) were investigated in patients with cT2/T3cN0 oral squamous cell carcinoma (OSCC).

Methods: This prospective multicenter trial involved 10 institutions nationwide in Japan. A total of 57 patients were enrolled. Read More

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The accuracy of intraoperative frozen section examination of sentinel lymph nodes in squamous cell cancer of the vulva.

Gynecol Oncol 2022 02 8;164(2):393-397. Epub 2021 Dec 8.

Department of Obstetrics and Gynaecology, Division of Gynecologic Oncology, University of Toronto, Toronto, ON, Canada; Gynecologic Oncology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada. Electronic address:

Objective: To assess the diagnostic accuracy of intraoperative pathologic examination of sentinel lymph nodes (SLNs) and patient outcomes in vulva cancer.

Methods: This retrospective study included patients with unifocal, <4 cm, invasive vulvar squamous cell carcinoma and clinically negative groin nodes treated with SLN biopsy from January 2008-March 2020. Intraoperative SLN frozen section and final pathology were compared. Read More

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February 2022

Outcomes of Sentinel Lymph Node Biopsy for Primary Cutaneous Squamous Cell Carcinoma of the Head and Neck.

Dermatol Surg 2022 02;48(2):157-161

Departments of Dermatology, and.

Background: Limited data exist on sentinel lymph node biopsy (SLNB) for cutaneous squamous cell carcinoma (cSCC) of the head and neck.

Objective: To review the results of SLNB for patients with cSCC of the head and neck at the authors' institution.

Materials And Methods: A retrospective review was completed for patients who underwent SLNB for cSCC of the head and neck over 19 years. Read More

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February 2022

Systematic review and meta-analysis of randomized controlled trials comparing elective neck dissection versus sentinel lymph node biopsy in early-stage clinically node-negative oral and/or oropharyngeal squamous cell carcinoma: Evidence-base for practice and implications for research.

Oral Oncol 2022 01 30;124:105642. Epub 2021 Nov 30.

Department of Radiation Oncology, ACTREC/TMH, Tata Memorial Centre, Homi Bhabha National Institute (HBNI), Mumbai, INDIA.

Purpose: Management of clinically node-negative (N0) neck in early-stage (T1-T2) oral and/or oropharyngeal squamous cell carcinoma (OOSCC) has been controversial. The purpose of this systematic review and meta-analysis was to compare sentinel lymph node biopsy (SLNB) with elective neck dissection (END) in early-stage OOSCC.

Methods: Studies comparing SLNB versus END in early-stage clinically node-negative OOSCC were identified using validated search strategy. Read More

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January 2022

Single-photon emission computed tomography (SPECT/CT) images of sentinel node distribution in oral cancer.

Br J Oral Maxillofac Surg 2021 Jul 29. Epub 2021 Jul 29.

Head & Neck Academic Centre, Division of Surgery & Interventional Science, University College London, Charles Bell House, 43045 Foley St, London W1W7TS, United Kingdom. Electronic address:

This audit describes the lymphatic flow from oral tumours seen on single-photon emission computed tomography (SPECT/CT) to help sentinel node (SN) identification. A total of 95 consecutive sentinel node biopsies (SNB) were taken between 2010 and 2019. Eligibility criteria for SNB were patients over 18 years of age with a T-T oral or oropharyngeal squamous cell carcinoma and an N neck. Read More

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