646 results match your criteria Sentinel Lymph Node Biopsy in Patients With Squamous Cell Carcinoma


Long-term speech and swallowing function after primary resection and sentinel node biopsy for early oral squamous cell carcinoma.

Oral Oncol 2019 Feb 9;89:127-132. Epub 2019 Jan 9.

Department of Otorhinolaryngology, Head and Neck Surgery, Kantonsspital St. Gallen, Switzerland.

Objectives: Analysis of long-term speech and swallowing function and subjective quality of life (QOL) after primary resection and sentinel node biopsy (SNB) in patients with early stage (cT1/T2) oral squamous cell carcinomas (OSCC).

Material And Methods: Eighty-one consecutive patients treated primarily by transoral resection without flap reconstruction and SNB for a cT1/T2 OSCC were included. Completion neck dissection (CND) was indicated in case of occult disease in the sentinel nodes. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2018.12.027DOI Listing
February 2019
2 Reads

Depth of invasion in patients with early stage oral cancer staged by sentinel node biopsy.

Head Neck 2019 Jan 28. Epub 2019 Jan 28.

Department of Head and Neck Surgical Oncology, UMC Utrecht Cancer Center, University Medical Center Utrecht, Utrecht, The Netherlands.

Background: To investigate if depth of invasion (DOI) can predict occult nodal disease in patients with cT1-2N0 (7th TNM) oral squamous cell carcinoma (OSCC) staged by sentinel lymph node biopsy (SLNB).

Methods: In 199 OSCC patients, DOI measurements and SLNB were performed.

Results: Metastases were found in 64 of 199 patients (32%). Read More

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http://dx.doi.org/10.1002/hed.25665DOI Listing
January 2019

The EANM practical guidelines for sentinel lymph node localisation in oral cavity squamous cell carcinoma.

Eur J Nucl Med Mol Imaging 2019 03 18;46(3):623-637. Epub 2018 Dec 18.

University Hospital San Pedro and Centre for Biomedical Research of La Rioja (CIBIR), Logroño, La Rioja, Spain.

Purpose: Sentinel lymph node biopsy is an essential staging tool in patients with clinically localized oral cavity squamous cell carcinoma. The harvesting of a sentinel lymph node entails a sequence of procedures with participation of specialists in nuclear medicine, radiology, surgery, and pathology. The aim of this document is to provide guidelines for nuclear medicine physicians performing lymphoscintigraphy for sentinel lymph node detection in patients with early N0 oral cavity squamous cell carcinoma. Read More

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http://link.springer.com/10.1007/s00259-018-4235-5
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http://dx.doi.org/10.1007/s00259-018-4235-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351508PMC
March 2019
12 Reads
5.383 Impact Factor

Topographical distribution of sentinel nodes and metastases from T1-T2 oral squamous cell carcinomas.

Eur J Cancer 2019 Jan 12;107:86-92. Epub 2018 Dec 12.

Department of Plastic and Reconstructive Surgery, Odense University Hospital, Denmark.

Objective: The objective is to investigate the topographical distribution of sentinel nodes (SNs) and lymph node metastases in T1-2cN0 oral squamous cell carcinomas (OSCCs).

Methods: The study entailed a prospective enrolment of 220 patients with clinical T1-2N0 OSCCs who underwent preoperative lymphoscintigraphy (LSG) followed by gamma probe-guided sentinel lymph node biopsy (SLNB). Patients with positive SNs were treated with completion neck dissection. Read More

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http://dx.doi.org/10.1016/j.ejca.2018.10.021DOI Listing
January 2019
4 Reads

Sentinel lymph nodes in vulvar cancer: Management dilemmas in patients with positive nodes and larger tumors.

Gynecol Oncol 2019 01 16;152(1):94-100. Epub 2018 Nov 16.

University of Toronto, Department of Obstetrics and Gynecology, Toronto, Ontario, Canada; Division of Gynecologic Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada. Electronic address:

Background: Although sentinel lymph node (SLN) biopsy has been routinely used in the treatment of invasive squamous cell carcinoma (SCC), questions still remain regarding the management of patients with positive nodes, as well as its use in patients with larger tumors.

Methods: Retrospective study of all patients at a single institution with primary vulvar cancer who had SLN biopsy (2008-2015). Patient and tumor characteristics were collected from hospital records. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00908258183136
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http://dx.doi.org/10.1016/j.ygyno.2018.10.047DOI Listing
January 2019
10 Reads

The role of inguinal lymph node dissection in men with urethral squamous cell carcinoma.

Urol Oncol 2018 12 13;36(12):526.e1-526.e6. Epub 2018 Nov 13.

Department of Surgery, Section of Urology, The University of Chicago, Chicago, IL.

Introduction: Urethral squamous cell cancer is a rare disease with limited clinical recommendations regarding management of the inguinal lymph nodes. Despite the similarities to penile cancer in terms of squamous cell carcinoma (SCC) histology and lymphatic drainage, there is not enough evidence to recommend for or against a prophylactic inguinal lymph node dissection (ILND) in patients with clinically negative groins and a primary tumor stage of T1b or higher. The objective of the study was to identify the rate of prophylactic inguinal lymph node dissection, node positive rate, and overall survival in patients with clinical T1 to T4 stage. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10781439183035
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http://dx.doi.org/10.1016/j.urolonc.2018.09.014DOI Listing
December 2018
11 Reads

Sentinel lymph node biopsy for early stage tongue cancer-a 14-year single-centre experience.

Int J Oral Maxillofac Surg 2018 Oct 30. Epub 2018 Oct 30.

Department of Oral and Maxillofacial Surgery, University Clinic of Zurich, Zurich, Switzerland.

This study was performed to report the usage of sentinel lymph node biopsy (SLNB) in clinical stage I or II tongue cancer patients with cN0 necks seen over a 14-year period. Data were collected prospectively, and a retrospective analysis was performed of 41 patients with early stage oral squamous cell carcinoma of the tongue and a cN0 neck. Sentinel lymph node (SLN)-positive patients underwent elective neck dissection, whereas SLN-negative patients were kept under careful observation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09015027183042
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http://dx.doi.org/10.1016/j.ijom.2018.10.011DOI Listing
October 2018
12 Reads

Sentinel Lymph Node Biopsy Versus Elective Neck Dissection for Stage I to II Oral Cavity Cancer.

Laryngoscope 2019 Jan 3;129(1):162-169. Epub 2018 Oct 3.

Department of Otolaryngology-Head and Neck Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, U.S.A.

Objectives: Sentinel lymph node biopsy (SLNB) has been shown to be an accurate technique for staging the neck in early-stage oral cavity squamous cell carcinoma (OCSCC) and has been incorporated in treatment guidelines as an option instead of elective neck dissection (END). However, utilization of SLNB in the United States remains unclear, and existing prospective studies did not directly compare survival between SLNB and END.

Methods: We conducted a retrospective cohort study of patients with stage I to II OCSCC (cT1-2cN0cM0) who underwent staging of the neck in the National Cancer Data Base from 2012 to 2015. Read More

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http://dx.doi.org/10.1002/lary.27323DOI Listing
January 2019
21 Reads

Intraoperative sentinel node imaging versus SPECT/CT in oral cancer - A blinded comparison.

Eur J Surg Oncol 2018 12 6;44(12):1901-1907. Epub 2018 Sep 6.

Department of Head and Neck Surgery, University College Hospital, 250 Euston Road, London, NW1 2AF, United Kingdom.

Introduction: Sentinel node biopsy (SNB) is gaining popularity as a staging tool in oral cancer. Protocol mandates radiotracer injection and pre-operative imaging (LSG ± SPECT/CT) in the nuclear medicine department. This approach limits application to accessible tumours and to centres with nuclear medicine. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07487983183130
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http://dx.doi.org/10.1016/j.ejso.2018.08.026DOI Listing
December 2018
13 Reads

Nodal staging of high-risk cutaneous squamous cell carcinoma.

J Am Acad Dermatol 2018 Sep 15. Epub 2018 Sep 15.

Department of Medicine, Dermatology Service, Memorial Sloan Kettering Cancer Center, New York, New York.

Background: While progress has been made in defining the clinical and histopathologic features of high-risk cutaneous squamous cell carcinoma (HRcSCC), optimal staging guidelines remain elusive.

Objective: We seek to guide clinical practice regarding nodal staging options for patients with HRcSCC via review of evolving definitions of HRcSCC, nodal staging options, and how nodal staging may impact treatment and affect outcomes.

Methods: This was a retrospective review of the published peer-reviewed literature regarding risk stratification, nodal staging, and treatment and outcomes for patients with HRcSCC via PubMed. Read More

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http://dx.doi.org/10.1016/j.jaad.2018.09.006DOI Listing
September 2018
2 Reads

Prognostic outcome and complications of sentinel lymph node navigation surgery for early-stage cervical cancer.

Int J Clin Oncol 2018 Dec 9;23(6):1167-1172. Epub 2018 Aug 9.

Department of Obstetrics and Gynecology, Faculty of Medicine, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.

Background: To evaluate the prognostic outcome and surgical complications in patients with early-stage cervical cancer who underwent sentinel node navigation surgery (SNNS) for hysterectomy or trachelectomy.

Methods: A total of 139 patients who underwent SNNS using Tc phytate between 2009 and 2015 were evaluated. No further lymph node dissection was performed when intraoperative analysis of the sentinel lymph nodes (SLNs) was negative for metastasis. Read More

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http://dx.doi.org/10.1007/s10147-018-1327-yDOI Listing
December 2018
4 Reads

Biopsy of the sentinel lymph node in oral squamous cell carcinoma: analysis of error in 100 consecutive cases.

Br J Oral Maxillofac Surg 2018 Sep 13;56(7):615-620. Epub 2018 Jul 13.

Department of Oral and Maxillofacial Surgery, Guy's Hospital, Guy's & Thomas' NHS Foundation Trust, Great Maze Pond, London, SE1 9RT, United Kingdom. Electronic address:

UK national guidelines in 2016 recommended that sentinel lymph node biopsy should be offered to patients with early oral cancer (T1-T2 N0) in which the primary site can be reconstructed directly. This study describes the pitfalls that can be avoided in the technique of biopsy to improve outcomes. We retrospectively analysed the data from 100 consecutive patients and recorded any adverse events. Read More

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http://dx.doi.org/10.1016/j.bjoms.2018.06.019DOI Listing
September 2018
7 Reads

SPECT/CT-guided lymph drainage mapping for the planning of unilateral elective nodal irradiation in head and neck squamous cell carcinoma.

Eur Arch Otorhinolaryngol 2018 Aug 28;275(8):2135-2144. Epub 2018 Jun 28.

Department of Radiation Oncology, Netherlands Cancer Institute/Antoni van Leeuwenhoek, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.

Purpose: To investigate the feasibility of lymph drainage mapping (LDM) using SPECT/CT to help select head and neck cancer (HNSCC) patients for unilateral elective neck irradiation (ENI). Patients with lateralized HNSCC treated with radiotherapy routinely undergo bilateral ENI, despite the incidence of contralateral regional failure being relatively low even after unilateral ENI. We hypothesized that patients with a lateralized tumor without visible lymph drainage to the contralateral neck have an extremely low risk of contralateral involved nodes. Read More

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http://dx.doi.org/10.1007/s00405-018-5050-0DOI Listing
August 2018
1 Read

The efficacy of ultrasound in the follow up after a negative sentinel lymph node in women with vulvar cancer: a prospective single-centre study.

BJOG 2018 Oct 1;125(11):1461-1468. Epub 2018 Aug 1.

Department of Obstetrics and Gynaecology, Radboud University Medical Center, Nijmegen, the Netherlands.

Objective: To determine the efficacy of the addition of an ultrasound of the groins in routine follow up of women with vulvar squamous cell carcinoma (SCC) after a negative sentinel lymph node (SLN).

Design: Prospective single-centre study.

Setting: A tertiary expert oncology centre for the treatment of vulvar cancer. Read More

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http://dx.doi.org/10.1111/1471-0528.15341DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175229PMC
October 2018
15 Reads

Sentinel node biopsy in early oral squamous cell carcinomas: Long-term follow-up and nodal failure analysis.

Oral Oncol 2018 Jul 6;82:187-194. Epub 2018 Jun 6.

Head & Neck Oncology Department, Gustave Roussy Cancer Campus, Grand Paris, France.

Objectives: Evaluate the reliability of sentinel node biopsy (SNB) in T1/T2 cN0 oral squamous cell carcinoma (OSCC), and compare recurrence-free time (RFT) and overall survival (OS) between patients undergoing SNB and neck dissection (ND).

Patients And Methods: Patients with T1/T2 cN0 OSCC underwent SNB followed by systematic ND in the first cohort and SNB followed by selective ND in case of positive sentinel nodes (SN) in the second cohort.

Results: A total of 229 patients were followed (first cohort 50, second cohort 179). Read More

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http://dx.doi.org/10.1016/j.oraloncology.2018.05.021DOI Listing

Surgical and Oncologic Outcomes of Radical Abdominal Trachelectomy Versus Hysterectomy for Stage IA2-IB1 Cervical Cancer.

J Minim Invasive Gynecol 2018 Jun 13. Epub 2018 Jun 13.

From the School of Medicine and Life Sciences (Drs. Guo and X. Chen), and the Department of Gynecologic Oncology (Drs. Zhang, Sun and Sheng), Shandong Cancer Hospital and Institute, University of Jinan-Shandong Academy of Medical Sciences, Jinan, Shandong, China(Drs. Guo, Zhang, X.Chen, Sun and Sheng), and the Department of Cardiothoracic Surgery, The 2nd Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China (Dr. K. Chen).. Electronic address:

Study Objective: To compare the surgical and oncologic outcomes between abdominal radical trachelectomy (ART) and radical hysterectomy (RH) for stage IA2-IB1 cervical cancer.

Design: A retrospective cohort study (Canadian Task Force classification II-2).

Setting: Shandong Cancer Hospital, Shandong, China. Read More

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http://dx.doi.org/10.1016/j.jmig.2018.06.006DOI Listing
June 2018
20 Reads

Sensitivity and specificity of sentinel lymph node biopsy in patients with oral squamous cell carcinomas using indocyanine green fluorescence imaging.

J Craniomaxillofac Surg 2018 Aug 23;46(8):1379-1384. Epub 2018 May 23.

Department of Oral and Maxillofacial Surgery, University Medical Center Hamburg-Eppendorf, (Head: Henning Hanken, MD, DMD, PhD), Martinistr. 52, 20246, Hamburg, Germany. Electronic address:

Purpose: The purpose of this clinical study was to evaluate the sensitivity and specificity of cervical sentinel lymph node biopsy after mapping with indocyanine green fluorescence (ICG) for imaging early-stage oral cancer.

Patients And Methods: A sentinel lymph node biopsy (SLNB) was performed during a selective neck dissection (SND) in 20 patients with oral squamous cell carcinoma (OSCC, cT1 or cT2, N0 status). The sentinel lymph nodes (SLN) were identified using an infrared video camera after ICG injection. Read More

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http://dx.doi.org/10.1016/j.jcms.2018.05.039DOI Listing
August 2018
3 Reads

Trends and Outcomes of Sentinel Lymph Node Biopsy in Early-stage Vulvar Squamous Cell Carcinoma: A Population-based Study.

J Cancer 2018 30;9(11):1951-1957. Epub 2018 Apr 30.

Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou 510060, People's Republic of China.

To compare trends and outcomes between lymphadenectomy and sentinel lymph node biopsy (SLNB) in node-negative early-stage vulvar squamous cell carcinoma (SCC) using a population-based cancer registry. Patients with vulvar SCC registered on the Surveillance, Epidemiology, and End Results program between 2003 and 2013 were identified. Statistical analysis was performed using Cox regression proportional hazards to calculate hazard ratio (HR) and 95% confidence interval (CI). Read More

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http://dx.doi.org/10.7150/jca.24044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995937PMC
April 2018
1 Read

Systematic review of the prevalence of nodal metastases and the prognostic utility of sentinel lymph node biopsy in cutaneous squamous cell carcinoma.

J Dermatol 2018 Jul 27;45(7):781-790. Epub 2018 Apr 27.

Dermatology Department, Instituto Valenciano de Oncología, Valencia, Spain.

Cutaneous squamous cell carcinoma (cSCC) is the second most common skin cancer and its incidence is rising. The prognosis is mostly good but patients with high-risk cSCC have a greater risk of recurrence and death. The aim of the present study was to conduct a systematic review analyzing the prevalence, predictors and prognostic utility of sentinel lymph node (SLN) involvement in cSCC. Read More

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http://dx.doi.org/10.1111/1346-8138.14342DOI Listing
July 2018
13 Reads

Sentinel Lymph Node Biopsy in Cutaneous Squamous Cell Carcinoma Series of 37 Cases and Systematic Review of the Literature.

Acta Derm Venereol 2018 Jul;98(7):671-676

Department of Dermatology, Hopital Saint Louis, FR-75010 Paris, France.

Cutaneous squamous cell carcinoma (cSSC) is one of the most common skin cancers and can lead to patient death. Early detection of node metastasis is a major goal for dermatologists and oncologists. The procedure sentinel lymph node biopsy has been proposed to improve early detection of node metastasis. Read More

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http://dx.doi.org/10.2340/00015555-2942DOI Listing
July 2018
26 Reads

High sensitivity and negative predictive value of sentinel lymph node biopsy in a retrospective early stage oral cavity cancer cohort in the Northern Netherlands.

Clin Otolaryngol 2018 Mar 25. Epub 2018 Mar 25.

Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Objectives: In cT1-2N0, oral squamous cell carcinoma (OSCC) occult metastases are detected in 23%-37% of cases. Sentinel lymph node biopsy (SLNB) was introduced in head and neck cancer as a minimally invasive alternative for an elective neck dissection in neck staging. Meta-analyses of SLNB accuracy show heterogeneity in the existing studies for reference standards, imaging techniques and pathological examination. Read More

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http://dx.doi.org/10.1111/coa.13107DOI Listing
March 2018
3 Reads

[18F]FDG PET/CT for assessing inguinal lymph nodes in patients with penile cancer - correlation with histopathology after inguinal lymphadenectomy.

Nuklearmedizin 2018 Feb 21;57(1):26-30. Epub 2018 Feb 21.

Aim: Accurate staging of penile cancer requires invasive methods such as sentinel node biopsy or lymphadenectomy (LAD). We assessed the value of [F]FDG PET/CT for non-invasive nodal staging in penile cancer (PC) patients before inguinal LAD.

Patients And Methods: 41 consecutive patients with PC (stage pT1 or higher, cN0) received [F]FDG PET/CT before undergoing bilateral modified or radical inguinal staging LAD. Read More

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http://dx.doi.org/10.3412/Nukmed-0932-17-10DOI Listing
February 2018
2 Reads

The efficacy of sentinel lymph node mapping with indocyanine green in cervical cancer.

World J Surg Oncol 2018 Mar 9;16(1):52. Epub 2018 Mar 9.

Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Asan Medical Center, 88 Olympic-ro, 43-gil, Songpa-gu, Seoul, 05505, Republic of Korea.

Background: Lymph node metastasis is a significant predictive factor for disease recurrence and survival in cervical cancer patients. Given the importance of lymph node metastasis, it is imperative that patients harboring metastasis are identified and can undergo appropriate treatment. Sentinel lymph node (SLN) mapping has drawn attention as a lymph node mapping technique. Read More

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http://dx.doi.org/10.1186/s12957-018-1341-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5845382PMC
March 2018
10 Reads

Cutaneous squamous cell carcinoma and the emerging role of sentinel lymph node biopsy.

G Ital Dermatol Venereol 2018 Jun 26;153(3):403-418. Epub 2018 Feb 26.

Department of Dermatology, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile -

Cutaneous squamous cell carcinoma (cSCC) is the second most common skin cancer and is usually associated with a favorable prognosis in most patients. However, a small minority of patients will be diagnosed with a high-risk cSCC (HRcSCC) and a proportion will have a poor outcome, in some cases causing death. HRcSCC is characterized by an increase in aggressiveness manifested as local recurrence, the development of lymph node metastases, and occasionally death. Read More

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http://dx.doi.org/10.23736/S0392-0488.18.05936-9DOI Listing
June 2018
6 Reads

SLN biopsy in cervical cancer patients with tumors larger than 2cm and 4cm.

Gynecol Oncol 2018 03 1;148(3):456-460. Epub 2018 Feb 1.

Gynecologic Oncology Center, Department of Obstetrics and Gynecology, First Faculty of Medicine, Charles University in Prague, General University Hospital in Prague, Czech Republic. Electronic address:

Objectives: The aim of this study was to assess the detection rate, false-negative rate and sensitivity of SLN in LN staging in tumors over 2cm on a large cohort of patients.

Methods: Data from patients with stages pT1a - pT2 cervical cancer who underwent surgical treatment, including SLN biopsy followed by systematic pelvic lymphadenectomy, were retrospectively analyzed. A combined technique with blue dye and radiocolloid was modified in larger tumors to inject the tracer into the residual cervical stroma. Read More

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http://dx.doi.org/10.1016/j.ygyno.2018.01.001DOI Listing
March 2018
3 Reads

Prognostic impact of preoperative serum interleukin-6 levels in patients with early-stage oral squamous cell carcinoma, defined by sentinel node biopsy.

Oncol Lett 2017 Dec 16;14(6):7965-7969. Epub 2017 Oct 16.

Department of Oral and Maxillofacial Surgery, Ehime University Graduate School of Medicine, Tōon, Ehime 791-0295, Japan.

Failure to detect recurrence and lymph node metastasis early represents a fundamental barrier to the improvement of survival rate in early stage oral squamous cell carcinoma (OSCC). The present study evaluated the association between serum interleukin-6 (IL-6) level and clinical outcomes in patients with early stage OSCC patients defined by sentinel node biopsy (SNB). A total of 53 patients with clinical stage I/II OSCC who underwent SNB were enrolled. Read More

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http://dx.doi.org/10.3892/ol.2017.7183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5755185PMC
December 2017
1 Read

Cutaneous squamous cell carcinoma: Management of advanced and high-stage tumors.

J Am Acad Dermatol 2018 02;78(2):249-261

Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

While the majority of cutaneous squamous cell carcinomas (cSCCs) can be treated surgically, the additional work-up and treatments indicated for high-risk cSCC remain undefined. In recent years, improvements in tumor staging systems have allowed for the more accurate stratification of tumors into high- and low-risk categories. This insight, along with the publication of cSCC guidelines, brings us closer to the development of a consensus approach. Read More

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http://dx.doi.org/10.1016/j.jaad.2017.08.058DOI Listing
February 2018
3 Reads

Cutaneous squamous cell carcinoma: Incidence, risk factors, diagnosis, and staging.

J Am Acad Dermatol 2018 02;78(2):237-247

Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

Cutaneous squamous cell carcinoma (cSCC), a malignant proliferation of cutaneous epithelium, represents 20% to 50% of skin cancers. Although the majority of cSCCs are successfully eradicated by surgical excision, a subset of cSCC possesses features associated with a higher likelihood of recurrence, metastasis, and death. The proper identification of these aggressive cSCCs can guide additional work-up and management. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01909622173232
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http://dx.doi.org/10.1016/j.jaad.2017.08.059DOI Listing
February 2018
7 Reads

Usage and survival implications of surgical staging of inguinal lymph nodes in intermediate- to high-risk, clinical localized penile cancer: A propensity-score matched analysis.

Urol Oncol 2018 04 26;36(4):159.e7-159.e17. Epub 2017 Dec 26.

Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX. Electronic address:

Objectives: To evaluate the usage of surgical staging of inguinal lymph nodes (SSILNs) in the United States for intermediate to high-risk, clinically localized penile squamous cell cancer (SCC), to explore patient and hospital factors associated with omission of this staging, and to evaluate the effect on survival.

Patients And Methods: Retrospective, observational study using the National Cancer Database from 2004 to 2014 of 1,689 men diagnosed with pT1b-T3, cN0 penile SCC, who by current guidelines should receive SSILNs-either by inguinal lymph node (ILN) dissection or sentinel node biopsy. Binomial logistic regression analysis was performed to determine predictors of SSILNs. Read More

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http://dx.doi.org/10.1016/j.urolonc.2017.12.001DOI Listing
April 2018
12 Reads

Evaluation of the diagnostic value of preoperative sentinel lymph node (SLN) imaging in penile carcinoma patients without palpable inguinal lymph nodes via single photon emission computed tomography/computed tomography (SPECT/CT) as compared to planar scintigraphy.

Urol Oncol 2018 03 14;36(3):92.e17-92.e24. Epub 2017 Dec 14.

Department of Nuclear Medicine, Molecular Imaging Diagnostics and Therapy, University Hospital Schleswig Holstein, Kiel, Germany.

Background: Sentinel lymph node (SLN) biopsy represents a well-established diagnostic tool for the assessment of lymphatic metastasis. Correct pre- and intraoperative visualization of SLN is of the utmost importance to ensure the safety and feasibility of the procedure. Aim of this study was to evaluate the diagnostic value of preoperative SLN imaging via single photon emission computed tomography/computed tomography (SPECT/CT) and planar scintigraphy in patients with penile carcinoma with nonpalpable inguinal lymph nodes. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10781439173060
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http://dx.doi.org/10.1016/j.urolonc.2017.11.012DOI Listing
March 2018
11 Reads

Preoperative sentinel lymph node localization in vulvar cancer: preliminary experience with inguinal intradermal contrast-enhanced ultrasound.

Eur Radiol 2018 May 30;28(5):2089-2095. Epub 2017 Nov 30.

Diagnostic Imaging Centre, Department of Clinical Radiology, Kuopio University Hospital, PO Box 100, FI-70029, Kuopio, Finland.

Objective: To evaluate the feasibility and diagnostic performance of intradermal contrast-enhanced ultrasound (CEUS) sentinel lymph node (SLN) procedure in vulvar cancer.

Methods: Twelve consecutive patients with vulvar cancer underwent preoperatively inguinal CEUS SLN examination and guide wire marking of the enhanced lymph nodes. Altogether, 20 groins were examined with CEUS contrast agent injections including 8 bilateral groins due to midline tumours. Read More

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http://dx.doi.org/10.1007/s00330-017-5155-7DOI Listing
May 2018
3 Reads

Importance of sentinel lymphatic node biopsy in detection of early micrometastases in patients with cutaneous squamous cell carcinoma.

J Plast Reconstr Aesthet Surg 2018 Apr 23;71(4):597-603. Epub 2017 Nov 23.

Plastic and Reconstructive Surgery Department, Hospital of Lithuanian University of Health Sciences Kauno Klinikos, Eivenių str. 2, Kaunas, Lithuania; Medical faculty, Lithuanian University of Health Sciences, A. Mickevičiaus str. 9, Kaunas, Lithuania.

Background: Cutaneous squamous cell carcinoma (CSCC) is the second most common malignant skin cancer with a tendency to spread through the lymphogenic pathway. Metastases are found in 2-6% of cases. The aim of this study was to determine CSCC micrometastases when non-invasive examination methods do not detect them. Read More

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http://dx.doi.org/10.1016/j.bjps.2017.10.019DOI Listing
April 2018
12 Reads

Rapid nodal staging of head and neck cancer surgical specimens with flow cytometric analysis.

Br J Cancer 2018 02 23;118(3):421-427. Epub 2017 Nov 23.

Division of ENT Diseases, Department of Clinical Sciences, Intervention and Technology, Karolinska Institutet, 171 77 Stockholm, Sweden.

Background: Detection of metastatic spread of head and neck cancer to cervical lymph nodes is essential for optimal design of therapy. Undetected metastases lead to mortality, which can be prevented by better detection methods.

Methods: We analysed 41 lymph nodes from 19 patients with oral squamous cell carcinoma (OSCC). Read More

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http://dx.doi.org/10.1038/bjc.2017.408DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5808027PMC
February 2018
9 Reads

Management of penile cancer in a Singapore tertiary hospital.

Arab J Urol 2017 Jun 30;15(2):123-130. Epub 2017 Mar 30.

Tan Tock Seng Hospital, Singapore, Singapore.

Objectives: To present our experience of managing penile squamous cell carcinoma (SCC) in a tertiary hospital in Singapore and to evaluate the prognostic value of the inflammatory markers neutrophil-lymphocyte ratio (NLR) and lymphocyte-monocyte ratio (LMR).

Patients And Methods: We reviewed our prospectively maintained Institutional Review Board-approved urological cancer database to identify men treated for penile SCC at our centre between January 2007 and December 2015. For all the patients identified, we collected epidemiological and clinical data. Read More

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http://dx.doi.org/10.1016/j.aju.2017.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5653614PMC
June 2017
20 Reads

Diagnostic value of sentinel lymph node biopsy for cT1/T2N0 tongue squamous cell carcinoma: a meta-analysis.

Eur Arch Otorhinolaryngol 2017 Nov 12;274(11):3843-3852. Epub 2017 Sep 12.

Department of Otolaryngology-Head and Neck Surgery, Eye, Ear, Nose and Throat Hospital, Fudan University, No. 83, Fenyang Road, Xuhui District, Shanghai, 200032, China.

The aim of this study was to systematically evaluate the diagnostic value of the sentinel lymph node biopsy (SLNB) for cT1/T2N0 tongue squamous cell carcinoma (TSCC) patients. A comprehensive and systematic literature review was performed by searching the Embase and PubMed databases for English language articles published up to December 2016. The pooled overall sentinel lymph node (SLN) detection rate, sensitivity and negative predictive value (NPV) were used to evaluate the diagnostic value of SLNB which used neck dissection or follow-up as a reference test. Read More

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http://dx.doi.org/10.1007/s00405-017-4740-3DOI Listing
November 2017
7 Reads

Sentinel lymph node biopsy for oral squamous cell carcinoma. Where are we now?

Br J Oral Maxillofac Surg 2017 Oct 30;55(8):757-762. Epub 2017 Aug 30.

Department of Oral and Maxillofacial Surgery, University College London Hospital, 235 Euston Road, Fitzrovia, London NW1 2BU.

Recent data have confirmed that elective surgical management of the cN0 neck improves survival in patients with early (T1-T2) oral squamous cell carcinoma (SCC), and is better than watchful waiting. However, elective neck dissection (END) may not always be necessary. Sentinel node biopsy (SNB), which is a reliable staging test for patients with early disease and a radiologically N0 neck, can detect occult metastases with a sensitivity of 86%-94%. Read More

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http://dx.doi.org/10.1016/j.bjoms.2017.07.007DOI Listing
October 2017
16 Reads

The combination of preoperative PET/CT and sentinel lymph node biopsy in the surgical management of early-stage cervical cancer.

J Cancer Res Clin Oncol 2017 Nov 1;143(11):2275-2281. Epub 2017 Jul 1.

Department of Obstetrics and Gynecology, University Hospital of Bern and University of Bern, Effingerstrasse 102, 3010, Bern, Switzerland.

Introduction: The aim of the study was to evaluate the use of PET/CT and/or SLN mapping alone or in combination in cervical cancer patients.

Materials And Methods: Data on stage IA1-IIA cervical cancer patients undergoing PET/CT and SLN mapping were retrospectively collected. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of PET/CT and SLN mapping, alone or in combination, in identifying cervical cancer patients with lymph node metastases were calculated. Read More

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http://dx.doi.org/10.1007/s00432-017-2467-6DOI Listing
November 2017
19 Reads

Cytokeratin 19 expression in early oral squamous cell carcinoma and their metastasis: Inadequate biomarker for one-step nucleic acid amplification implementation in sentinel lymph node biopsy procedure.

Head Neck 2017 09 23;39(9):1864-1868. Epub 2017 Jun 23.

Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands.

Background: Intraoperative analysis of lymph nodes during a sentinel lymph node biopsy (SLNB) procedure could result in one-step surgery for early oral squamous cell carcinoma (OSCC) with an occult nodal metastasis. One-step nucleic acid amplification rapidly detects cytokeratin 19 (CK19) RNA with high accuracy. Sensitivity and specificity of CK19 expression in OSCC was evaluated. Read More

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http://dx.doi.org/10.1002/hed.24847DOI Listing
September 2017
11 Reads

High-risk squamous cell carcinoma of the ear - A potential role for sentinel node biopsy.

Head Neck 2017 09 22;39(9):1840-1844. Epub 2017 Jun 22.

Department of Plastic and Reconstructive Surgery, University College Hospital, Galway, National University of Ireland, Galway.

Background: Squamous cell carcinomas (SCCs) of the external ear have a significant rate of metastasis. The purpose of this study was to present analyzed factors associated with auricular SCC metastasis in order to identify a group that may benefit from sentinel lymph node biopsy (SLNB).

Methods: We performed a retrospective review of all operable SCCs between 2009 and 2014. Read More

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http://dx.doi.org/10.1002/hed.24843DOI Listing
September 2017
6 Reads

Can We Define the Risk of Lymph Node Metastasis in Early-Stage Cervical Cancer Patients? A Large-Scale, Retrospective Study.

Ann Surg Oncol 2017 Aug 12;24(8):2311-2318. Epub 2017 Jun 12.

Gynecologic Oncology Unit, Fondazione "Policlinico Universitario A. Gemelli", Rome, Italy.

Background: Sentinel lymph node (SLN) biopsy has emerged as one of the most appreciated techniques for reducing the rate of complete lymph node dissection (LND) performed in patients with early-stage cervical cancer (ECC). However, its performances are still a matter of debate and, to improve them, international guidelines recommend performing at least unilateral LND in case of SLN mapping. In a prior study, we identified a group of patients without evidence of lymph node metastasis (LNM). Read More

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http://dx.doi.org/10.1245/s10434-017-5917-0DOI Listing
August 2017
36 Reads

The rate of facial nerve dysfunction and time to recovery after intraparotid and extraparotid facial nerve exposure and protection in head and neck cutaneous tumor surgery.

Int J Clin Oncol 2017 Oct 9;22(5):843-848. Epub 2017 Jun 9.

Department of Skin Oncology/Dermatology, Saitama Medical University International Medical Center, 1397-1 Yamane, Hidaka, Saitama, 350-1298, Japan.

Background: Most patients with head and neck skin tumors present with normal facial nerve function. A common treatment strategy for these patients is facial nerve preservation surgery, although the degree to which the nerve is successfully preserved is still unclear. Data on the incidence and recovery of facial nerve dysfunction are woefully lacking in the field of dermato-oncology. Read More

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http://dx.doi.org/10.1007/s10147-017-1148-4DOI Listing
October 2017
24 Reads

Lip reconstruction using a functioning serratus anterior free flap: preliminary study.

Int J Oral Maxillofac Surg 2017 Oct 19;46(10):1243-1247. Epub 2017 May 19.

Department of Plastic, Reconstructive and Aesthetic Surgery, Necmettin Erbakan University, Medical Faculty of Meram, Konya, Turkey.

Reconstructive surgery to the lips requires the replacement of defective tissues with similarly functioning tissues. While non-dynamic free tissue transfers provide adequate lower lip reconstruction, improved benefits may be obtained with innervated free muscle flaps. This study reports the use of innervated serratus anterior muscle free flaps for lip reconstruction in five patients. Read More

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http://dx.doi.org/10.1016/j.ijom.2017.04.026DOI Listing
October 2017
4 Reads

Role of ICG-Tc-nanocolloid for sentinel lymph node detection in cervical cancer: a pilot study.

Eur J Nucl Med Mol Imaging 2017 Oct 10;44(11):1853-1861. Epub 2017 May 10.

Nuclear Medicine Department, Hospital Clínic, Villarroel, 170 08036, Barcelona, Spain.

Purpose: Sentinel lymph node biopsy (SLNB) can be used for nodal staging in early cervical cancer. For this purpose, the tracers most commonly used are radiotracers based on technetium. For the last decade, indocyanine green (ICG) has been used as a tracer for SLNB in other malignancies with excellent results and, more recently, a combination of ICG and a radiotracer has been shown to have the advantages of both tracers. Read More

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http://dx.doi.org/10.1007/s00259-017-3706-4DOI Listing
October 2017
21 Reads

Sentinel Lymph Node Biopsy: A new approach in the management of head and neck cancers.

Sultan Qaboos Univ Med J 2017 Feb 30;17(1):e3-e10. Epub 2017 Mar 30.

Department of Oral & Maxillofacial Pathology, Christian Dental College & Hospital, Ludhiana, Punjab, India.

Cervical lymph node metastasis affects the prognosis and overall survival rate of and therapeutic planning for patients with head and neck squamous cell carcinomas (HNSCCs). However, advanced diagnostic modalities still lack accuracy in detecting occult neck metastasis. A sentinel lymph node biopsy is a minimally invasive auxiliary method for assessing the presence of occult metastatic disease in a patient with a clinically negative neck. Read More

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http://dx.doi.org/10.18295/squmj.2016.17.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5380418PMC
February 2017
5 Reads

Prognostic Value of the Staging System for Eyelid Tumors in the 7th Edition of the American Joint Committee on Cancer Staging Manual.

Ophthalmic Plast Reconstr Surg 2017 Sep/Oct;33(5):317-324

*Orbital Oncology and Ophthalmic Plastic Surgery, Department of Plastic Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, and †Department of Ophthalmology, Tulane University, New Orleans, Louisiana, U.S.A.

Purpose: To determine the prognostic value of the staging criteria for eyelid tumors in the 7th edition of the American Joint Committee on Cancer (AJCC) staging manual and to determine, for each type of eyelid tumor, which AJCC T categories are associated with increased risk of nodal metastasis and thus potential usefulness of sentinel lymph node biopsy.

Methods: Systematic review and analysis of articles found by searching PubMed and Google Scholar using the search terms "AJCC," "eyelid," "carcinoma," and "melanoma."

Results: Rates of local recurrence, regional nodal metastasis, and distant metastasis were approximately 7% to 10%, 1% to 9%, and 0% to 0. Read More

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http://dx.doi.org/10.1097/IOP.0000000000000901DOI Listing
September 2017
6 Reads

Cytogenetic analysis of metaplastic squamous cell carcinoma of the breast inter- and intratumoral heterogeneity.

Breast Cancer 2017 Nov 18;24(6):733-741. Epub 2017 Mar 18.

The Departments of Breast Oncology, National Kyushu Cancer Center, 3-1-1 Notame, Minami-ku, Fukuoka, 811-1347, Japan.

Background: Squamous cell carcinoma (SCC) of the breast is a rare and generally aggressive disease that accounts for less than 0.1% of all breast carcinomas. Although SCCs have distinct morphological features, their origin and cytogenetic profile are not well understood. Read More

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http://dx.doi.org/10.1007/s12282-017-0768-xDOI Listing
November 2017
11 Reads

Longitudinal monitoring of the head and neck lymphatics in response to surgery and radiation.

Head Neck 2017 06 6;39(6):1177-1188. Epub 2017 Mar 6.

Center for Molecular Imaging, The Brown Foundation Institute of Molecular Medicine at The University of Texas Health Science Center at Houston, Houston, Texas.

Background: The lymphatic vasculature provides a route for cancer metastases, and its dysfunction after cancer treatment can result in lymphedema. However, changes in the lymphatics before, during, and after surgery and radiation remain unclear.

Methods: Near-infrared fluorescence lymphatic imaging was performed before and after lymph node dissection and fractionated radiotherapy to assess changes in external lymphatic function. Read More

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http://dx.doi.org/10.1002/hed.24750DOI Listing
June 2017
10 Reads

Management of the clinically node negative neck in squamous cell carcinoma of the maxilla.

Oral Oncol 2017 03 21;66:87-92. Epub 2017 Jan 21.

Department of Head and Neck Surgical Oncology, UMC Utrecht Cancer Center, University Medical Center Utrecht, Utrecht, The Netherlands. Electronic address:

Objective: The management of the clinically node negative (N0) neck in patients with squamous cell carcinoma of the maxilla (MSCC) is a matter of debate. In this retrospective cohort study the incidence of occult metastases is determined in clinically N0 MSCCs, as well as histopathological factors associated with occult metastases.

Patients And Methods: 95 patients with clinically N0 MSCCs had maxillectomy. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2016.12.027DOI Listing
March 2017
13 Reads

Sensitivity and negative predictive value for sentinel lymph node biopsy in women with early-stage cervical cancer.

Gynecol Oncol 2017 04 8;145(1):96-101. Epub 2017 Feb 8.

Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, United States. Electronic address:

Objective: The role of sentinel lymph node (SLN) biopsy alone for staging of early-stage cervical cancer remains controversial. We aimed to determine the validity of this technique in women with early-stage cervical cancer.

Methods: We retrospectively reviewed women with early-stage cervical cancer who underwent SLN mapping followed by complete pelvic lymphadenectomy as part of initial surgical management from August 1997 through October 2015. Read More

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http://dx.doi.org/10.1016/j.ygyno.2017.02.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5873580PMC
April 2017
17 Reads

Topography of the sentinel node according to the affected lobe in lung cancer.

Clin Transl Oncol 2017 Jul 27;19(7):858-864. Epub 2017 Jan 27.

Servicio de Biología Molecular, Del Hospital Universitario de La Ribera, Crta. Corbera, km. 1, 46600, Alcira, Valencia, Spain.

Purpose: The objective of this study is to describe the anatomic location of the sentinel lymph node (SLN) of patients with lung carcinoma and to analyze its relationship with the characteristics of the tumor.

Patients And Methods: 98 Stage I lung cancer patients were included in the study. SLN was marked just after performing the thoracotomy by injecting peritumorally 0. Read More

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http://dx.doi.org/10.1007/s12094-017-1615-4DOI Listing
July 2017
1 Read