2,628 results match your criteria Sentinel Lymph Node Biopsy in Patients With Melanoma


Challenges in sentinel node pathology in the era of adjuvant treatment.

J Surg Oncol 2020 Jun 29. Epub 2020 Jun 29.

Departments of Surgical Oncology, Netherlands Cancer Institute - Antoni van Leeuwenhoek, Amsterdam, The Netherlands.

Background: With the approval of adjuvant therapy for stage III melanoma, accurate staging is more important than ever. Sentinel node biopsy (SNB) is an accurate staging tool, yet the presence of capsular nevi (CN) can lead to a false-positive diagnosis.

Patients And Methods: Retrospective analysis of the American Joint Committee on Cancer 7th edition stage IIIA melanoma patients who were treated at our institute between 2000 and 2015. Read More

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http://dx.doi.org/10.1002/jso.26095DOI Listing

[Cutaneous squamous cell carcinoma].

Hautarzt 2020 Jun 24. Epub 2020 Jun 24.

Klinik für Dermatologie und Venerologie, Vivantes Klinikum Neukölln, Berlin, Deutschland.

Cutaneous squamous cell carcinoma (cSCC) is one of the most common cancers of the Caucasian population and accounts for 20% of all skin tumours. An S3 guideline of the German Guideline Program in Oncology has been available since 2019. The diagnosis is based on the clinical examination. Read More

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http://dx.doi.org/10.1007/s00105-020-04620-4DOI Listing

Adjuvant nodal radiation therapy for melanoma in the era of immunotherapy.

Int J Radiat Oncol Biol Phys 2020 Jun 13. Epub 2020 Jun 13.

Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center.

In the last few years there have been dramatic changes in the management of melanoma patients with locally advanced disease. Previously, standard therapy for melanoma patients with nodal disease involved completion lymph node dissection followed by adjuvant radiation therapy for high risk features, as defined by TROG 02.01. Read More

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http://dx.doi.org/10.1016/j.ijrobp.2020.06.006DOI Listing

Acral Lentiginous Melanoma: Do Surgical Approach and Sentinel Lymph Node Biopsy Matter?

Plast Reconstr Surg Glob Open 2020 Mar 25;8(3):e2698. Epub 2020 Mar 25.

Division of Surgical Oncology, Department of Surgery, Oregon Health & Science University, Portland, Ore.

Management of acral lentiginous melanoma (ALM) remains controversial. Traditionally, ALM was managed with digit amputation (DA), resulting in significant morbidity, but recent evidence has advocated for digit sparing management. Furthermore, the significance of nodal metastasis for ALM is not well reported. Read More

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http://dx.doi.org/10.1097/GOX.0000000000002698DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253243PMC

The Devil's in the Details: Discrepancy Between Biopsy Thickness and Final Pathology in Acral Melanoma.

Ann Surg Oncol 2020 Jun 11. Epub 2020 Jun 11.

Department of Surgery, NYU Langone Health, 462 First Ave, NBV 15S6, New York, NY, 10016, USA.

Purpose: We hypothesized that initial biopsy may understage acral lentiginous melanoma (ALM) and lead to undertreatment or incomplete staging. Understanding this possibility can potentially aid surgical planning and improve primary tumor staging.

Methods: A retrospective review of primary ALMs treated from 2000 to 2017 in the US Melanoma Consortium database was performed. Read More

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http://dx.doi.org/10.1245/s10434-020-08708-yDOI Listing

Sentinel Lymph Node Biopsy Is Prognostic in Thickest Melanoma Cases and Should Be Performed for Thick Melanomas.

Ann Surg Oncol 2020 Jun 10. Epub 2020 Jun 10.

Moffitt Cancer Center, Tampa, FL, USA.

Background: Sentinel lymph node biopsy (SLNB) is recommended for intermediate thickness melanoma, but for thick melanoma, guidelines are less definitive about the use of SLNB in this population. We present a study on thick melanoma evaluating for prognostic factors.

Patients And Methods: The Sentinel Lymph Node Working Group database was queried for thick (> 4 mm) melanoma cases that had a SLNB from 1993 to 2018. Read More

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http://dx.doi.org/10.1245/s10434-020-08706-0DOI Listing

Patients with cutaneous head and neck melanoma, particularly elderly with more advanced primary tumors, seem to benefit from initial CT staging before considering a sentinel lymph node biopsy.

Acta Otolaryngol 2020 Jun 10:1-8. Epub 2020 Jun 10.

Department of ORL, Head and Neck Surgery, Skåne University Hospital, Lund, Sweden.

The role of CT scanning at the time of diagnosis for patients with primary cutaneous head and neck melanoma (cHNM) clinically asymptomatic for metastatic disease remains unclear. To determine the positive yield of initial CT scanning before considering sentinel lymph node biopsy (SLNB) staging. A retrospective review was performed on 170 consecutive patients with cHNM referred to a tertiary head and neck academic center for SLNBs from 2014 through 2018. Read More

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http://dx.doi.org/10.1080/00016489.2020.1772503DOI Listing

Sentinel Lymph Node Biopsy for T1b Melanoma: Balancing Prognostic Value and Cost.

Ann Surg Oncol 2020 Jun 8. Epub 2020 Jun 8.

Division of Surgical Oncology, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Background: The purpose of this study is to report the additional prognostic information and cost associated with sentinel lymph node biopsy (SLNB) for patients with T1b melanoma.

Patients And Methods: An institutional database was queried for patients with T1b melanoma (0.8-1. Read More

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http://dx.doi.org/10.1245/s10434-020-08558-8DOI Listing

Deep Penetrating Nevus and Borderline-Deep Penetrating Nevus: A Literature Review.

Front Oncol 2020 20;10:837. Epub 2020 May 20.

Division of Health Care Sciences, Center for Clinical Research and Management Education, Dresden International University, Dresden, Germany.

Deep penetrating nevi (DPN) are rare melanocytic nevi, which can exhibit atypical histological features hampering the differentiation from malignant melanoma. DPN are considered benign melanocytic lesions, but rare spread to lymph nodes and unfavorable clinical outcomes associated with borderline/atypical DPN (B-DPN) has been reported. Since no guidelines are available for DPN and B-DPN, we aimed to review the literature on DPN and B-DPN to assess the management and prognosis. Read More

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http://dx.doi.org/10.3389/fonc.2020.00837DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251176PMC

Isolated gallbladder metastasis of melanoma: Case report.

Int J Surg Case Rep 2020 14;71:311-314. Epub 2020 May 14.

General Surgery Department, British Hospital of Buenos Aires, Perdriel 74, CABA, 1280, Argentina.

Background: Although metastatic melanoma is most frequently found in liver, lungs, and brain, most metastases found in the gallbladder are from melanoma. Here, we present a case of isolated metastatic melanoma found during cholecystectomy.

Presentation Of Case: 74-year-old male with a personal history of hypertension, diabetes mellitus, obesity, and arrhythmia. Read More

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http://dx.doi.org/10.1016/j.ijscr.2020.04.086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7264460PMC

Nodal and systemic recurrence following observation of a positive sentinel lymph node in melanoma.

Br J Surg 2020 Jun 2. Epub 2020 Jun 2.

Departments of Surgery, Memorial Sloan Kettering Cancer Center, New York, USA.

Background: Two RCTs found no survival benefit for completion lymphadenectomy after positive sentinel lymph node biopsy compared with observation with ultrasound in patients with melanoma. Recurrence patterns and regional control are not well described for patients undergoing observation alone.

Methods: All patients with a positive sentinel node biopsy who did not have immediate completion lymphadenectomy were identified from a single-institution database (1995-2018). Read More

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http://dx.doi.org/10.1002/bjs.11621DOI Listing

Oncological outcome of videoscopic groin dissection for lymph node metastasis from melanoma.

Surg Endosc 2020 Jun 1. Epub 2020 Jun 1.

Surgical Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy.

Background: Videoscopic inguinal lymphadenectomy (VIL) represents an innovative approach for patients with melanoma lymph node (LN) metastases, mainly aimed at lowering wound-related morbidity. However, long-term data on oncologic safety are still lacking. The aim of this study is to review the oncologic outcome of videoscopic groin dissection in a single institution caseload. Read More

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http://dx.doi.org/10.1007/s00464-020-07675-5DOI Listing

Sentinel Lymph Node Biopsy: Indications and Technique.

Surg Oncol Clin N Am 2020 Jul;29(3):401-414

The Angeles Clinic and Research Institute, Cedars-Sinai Medical Center, 11800 Wilshire Boulevard, Suite 300, Los Angeles, CA 90025, USA. Electronic address:

Sentinel lymph node biopsy is a key tool in the care of many patients with melanoma. The indications for the procedure have gradually become clearer over the 3 decades since the technique was developed. For appropriately selected patients, it carries enormous significance. Read More

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http://dx.doi.org/10.1016/j.soc.2020.02.006DOI Listing

Risk Factors for Complications and Long-Term Outcomes Following Completion Lymph Node Dissection for Cutaneous Melanoma: A Retrospective Cohort Study.

J Plast Reconstr Aesthet Surg 2020 Mar 17. Epub 2020 Mar 17.

Division of Reconstructive Plastic Surgery, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden; Clinic of Reconstructive Plastic Surgery, Karolinska University Hospital, Stockholm, Sweden. Electronic address:

Background: Completion lymph node dissection (CLND) for malignant melanoma is performed for regional cancer control and is associated with a high complication rate. It is unknown whether post-operative complications influence cancer recurrence or survival. Our aim was to evaluate the risk factors for short- and long-term complications after CLND, and to determine whether complications affect recurrence or survival. Read More

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http://dx.doi.org/10.1016/j.bjps.2020.02.038DOI Listing

Australian general practitioners' attitudes and knowledge of sentinel lymph node biopsy in melanoma management.

Aust J Gen Pract 2020 06;49(6):355-362

MPH (Hons), PhD, Head of Cancer Epidemiology and Prevention Research Group, Sydney School of Public Health and Melanoma Institute Australia, University of Sydney, NSW; Professor of Cancer Epidemiology, Sydney Medical School, University of Sydney, NSW.

Background And Objectives: In Australia, the uptake of the sentinel lymph node biopsy (SLNB) appears low despite clinical practice guideline recommendations. The aim of this study was to describe the knowledge and attitudes of general practitioners (GPs) to SLNB.

Method: GPs were recruited at an annual conference and a skin cancer skills workshop, and using GP professional communications. Read More

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http://dx.doi.org/10.31128/AJGP-10-19-5138DOI Listing

[Locally advanced and metastatic melanoma : novelties].

Rev Med Suisse 2020 May;16(695):1092-1097

Service d'oncologie médicale, Département d'oncologie, CHUV, 1011 Lausanne.

The standard of care of melanoma patients has evolved at a rapid pace with the advent of immune checkpoint inhibitors and BRAF and MEK inhibitors. ESMO guidelines were revised in September 2019 to integrate the results of recent studies that broaden the indication of these treatments to the adjuvant setting and validated new limitations to completion lymph node dissection in the case of a positive sentinel lymph node biopsy in locally advanced melanoma. We hereby detail the main novelties of the revised ESMO 2019 guidelines. Read More

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Does early timing of lymph node surgery after resection of the primary tumour improve the clinical outcome of melanoma patients?

Clin Exp Dermatol 2020 May 18. Epub 2020 May 18.

Translational Skin Cancer Research, German Cancer Consortium (DKTK) Partner Site Essen/Düsseldorf, Department of Dermatology, University Duisburg-Essen, Essen, Germany.

Background: In patients with cutaneous melanoma (CM), the time span between resection of the primary tumour and sentinel lymph node biopsy (SLNB) as well as the subsequent interval between SLNB and complete lymph node dissection (CLND) varies greatly.

Objectives: To determine whether very early timing of SLNB after resection of the primary tumour or timing of CLND after SLNB, respectively, affect the clinical outcome of CM patients compared to longer time intervals.

Methods: We compared the time spans between complete resection of the primary tumour and SLNB or the interval between SLNB and CLND in a cohort of 896 melanoma patients who had underwent SLNB. Read More

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http://dx.doi.org/10.1111/ced.14291DOI Listing

Sentinel Lymph Node Biopsy Has No Therapeutic Value in Melanoma and Is Not Useful for Selecting Patients Who Could Benefit From Adjuvant Immunotherapy.

Actas Dermosifiliogr 2020 May 14. Epub 2020 May 14.

Servicio de Dermatología, Complexo Hospitalario Universitario de Vigo, Vigo, Pontevedra, España.

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http://dx.doi.org/10.1016/j.ad.2020.02.003DOI Listing

Primary dermal melanoma: clinical behaviour, prognosis and treatment.

Eur J Surg Oncol 2020 May 1. Epub 2020 May 1.

Melanoma Institute Australia, The University of Sydney, Sydney, NSW, Australia; Royal Prince Alfred Hospital, Camperdown, NSW, Australia; Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia. Electronic address:

Purpose: Primary dermal melanoma (PDM) is a subtype of cutaneous melanoma, confined to the dermis, which poses a challenging clinical dilemma. It may represent a true primary melanoma or a dermal cutaneous metastasis. This study aimed to delineate the histopathological characteristics and prognosis of PDM in a large patient cohort to guide appropriate treatment strategies. Read More

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http://dx.doi.org/10.1016/j.ejso.2020.04.043DOI Listing
May 2020
3.009 Impact Factor

Model Combining Tumor Molecular and Clinicopathologic Risk Factors Predicts Sentinel Lymph Node Metastasis in Primary Cutaneous Melanoma.

JCO Precis Oncol 2020 14;4:319-334. Epub 2020 Apr 14.

Mayo Clinic, Rochester, MN, USA.

Purpose: More than 80% of patients who undergo sentinel lymph node (SLN) biopsy have no nodal metastasis. Here we describe a model that combines clinicopathologic and molecular variables to identify patients with thin and intermediate thickness melanomas who may forgo the SLN biopsy procedure due to their low risk of nodal metastasis.

Patients And Methods: Genes with functional roles in melanoma metastasis were discovered by analysis of next generation sequencing data and case control studies. Read More

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http://dx.doi.org/10.1200/po.19.00206DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220172PMC

Increase of sentinel lymph node melanoma staging in The Netherlands; still room and need for further improvement.

Melanoma Manag 2020 Mar 30;7(1):MMT38. Epub 2020 Mar 30.

Department of Surgical Oncology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Aim: To investigate implementation of the seventh American Joint Committee on Cancer melanoma staging with sentinel lymph node biopsy (SLNB) and associations with socioeconomic status (SES).

Patients & Methods: Data from The Netherlands Cancer Registry on patient and tumor characteristics were analyzed for all stage IB-II melanoma cases diagnosed 2010-2016, along with SES data from The Netherlands Institute for Social Research.

Results: The proportion of SLNB-staged patients increased from 40% to 65% (p < 0. Read More

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http://dx.doi.org/10.2217/mmt-2019-0018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212513PMC

Elderly Age Is Associated With More Conservative Treatment of Invasive Melanoma.

Anticancer Res 2020 May;40(5):2895-2903

Division of Surgical Oncology, Department of Surgery, University of California, Davis Medical Center, Sacramento, CA, U.S.A.

Background/aim: Competing mortality risks complicate treatment of elderly melanoma patients potentially leading to conservative management, including no sentinel lymph node biopsy. As systemic immunotherapy offers justification for nodal evaluation, we examined treatment trends among elderly melanoma patients.

Patients And Methods: We performed a National Cancer Database analysis of melanoma patients from 2004-2015. Read More

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http://dx.doi.org/10.21873/anticanres.14266DOI Listing

Adjuvant Therapy is Effective for Melanoma Patients with a Positive Sentinel Lymph Node Biopsy Who Forego Completion Lymphadenectomy.

Ann Surg Oncol 2020 Apr 20. Epub 2020 Apr 20.

Department of Surgery, Duke University Medical Center, Durham, NC, USA.

Background: Multiple adjuvant therapies for melanoma have been approved since 2015 based on randomized trials demonstrating improvements in recurrence-free survival (RFS) with adjuvant therapy after surgical resection of high-risk disease. Inclusion criteria for these trials required performance of a completion lymph node dissection (CLND) for positive sentinel lymph node (pSLN) disease.

Objective: We aimed to describe current practice for adjuvant therapies in patients with pSLN without CLND (active surveillance [AS]), and to evaluate recurrence in these patients. Read More

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http://dx.doi.org/10.1245/s10434-020-08478-7DOI Listing

Sentinel Lymph Node Biopsy Still Provides No Benefits for Patients With Melanoma.

Authors:
Samuel Zagarella

Am J Dermatopathol 2020 Jul;42(7):481-483

Department of Dermatology, University of Sydney Medical School, Sydney, Australia.

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http://dx.doi.org/10.1097/DAD.0000000000001656DOI Listing

GPs' involvement in diagnosing, treating, and referring patients with suspected or confirmed primary cutaneous melanoma: a qualitative study.

BJGP Open 2020 23;4(2). Epub 2020 Jun 23.

Professor of Cancer Epidemiology, Cancer Epidemiology and Prevention Research, Sydney School of Public Health, The University of Sydney, Sydney, Australia.

Background: In Australia, melanoma is managed in primary and secondary care settings. An individual concerned about a suspicious lesion typically presents first to their GP.

Aim: To identify factors influencing GPs' decisions to diagnose, treat, or refer patients with suspected melanoma. Read More

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http://dx.doi.org/10.3399/bjgpopen20X101028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330208PMC

Compounding Benefits of Sentinel Lymph Node Biopsy for Perineal Melanoma: A Population-Based Retrospective Cohort Analysis.

Ann Plast Surg 2020 May;84(5S Suppl 4):S257-S263

From the Division of Plastic and Reconstructive Surgery, Stanford University Medical Center, Stanford University, Palo Alto, CA.

Introduction: Sentinel lymph node biopsy (SLNB) in the treatment of melanoma is known to provide valuable prognostic information. However, there is no literature describing an overall or disease-specific survival (DDS) benefit of SLNB. In the perineum, melanoma is often more advanced at presentation with current treatment guidelines translated from nonanatomic specific melanoma. Read More

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http://dx.doi.org/10.1097/SAP.0000000000002388DOI Listing

Defining the Prognostic Role of MicroRNAs in Cutaneous Melanoma.

J Invest Dermatol 2020 Apr 8. Epub 2020 Apr 8.

Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.

Breslow thickness (BT) is the most important histopathologic factor for primary melanoma staging. BT determines the margins for wide local excision whether sentinel lymph node biopsy should be performed and subsequent melanoma staging, and patient management. The correct determination of a 0. Read More

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http://dx.doi.org/10.1016/j.jid.2020.03.949DOI Listing
April 2020
7.216 Impact Factor

Near Infrared (NIR) Fluorescence is Not a Substitute for Lymphoscintigraphy and Gamma Probe for Melanoma Sentinel Node Detection: Results from a Prospective Trial.

Ann Surg Oncol 2020 Aug 7;27(8):2906-2912. Epub 2020 Apr 7.

Department of Surgery, Melanoma and Sarcoma, Barretos Cancer Hospital, Barretos, SP, Brazil.

Background: Sentinel lymph node (SLN) biopsy is the standard care for early detection and staging of lymph node metastasis in melanomas. Radiocolloids (RC) and blue dyes are used for SLN detection. Recently, near infrared (NIR) fluorescence tracing using indocyanine green has been developed as an alternative method for SLN detection. Read More

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http://dx.doi.org/10.1245/s10434-020-08409-6DOI Listing

The Clinicopathological and Survival Profiles Comparison Across Primary Sites in Acral Melanoma.

Ann Surg Oncol 2020 Apr 6. Epub 2020 Apr 6.

Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Renal Cancer and Melanoma, Peking University Cancer Hospital and Institute, Haidian District, Beijing, China.

Background: The clinicopathological and survival profiles across primary sites in acral melanoma (AM) are still controversial and unclear.

Methods: This is a multi-center retrospective study. Clinicopathological data of AM patients diagnosed between 1 January 2000 and 31 December 2017 from 6 large tertiary hospitals in China were extracted. Read More

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http://dx.doi.org/10.1245/s10434-020-08418-5DOI Listing
April 2020
3.930 Impact Factor

Children with malignant melanoma: a single center experience from Turkey.

Turk Pediatri Ars 2020 9;55(1):39-45. Epub 2020 Mar 9.

Department of Pediatric Hematology-Oncology, İstanbul University, Oncology Institute, İstanbul, Turkey.

Aim: Malignant melanoma is the most frequent skin cancer in children and adolescents. It comprises 1-3% of all malignancies. In this study, we aimed to evaluate the clinical aspects, histopathologic features, and treatment outcomes of our patients with malignant melanoma. Read More

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http://dx.doi.org/10.14744/TurkPediatriArs.2019.90022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7096563PMC

Molecular risk prediction in cutaneous melanoma: a meta-analysis of the 31-gene expression profile prognostic test in 1,479 patients.

J Am Acad Dermatol 2020 Mar 27. Epub 2020 Mar 27.

University of California-San Francisco; San Francisco Veterans Affairs Medical Center.

Background: Multiple studies have reported on the accuracy of the prognostic 31-gene expression profile test (31-GEP) for cutaneous melanoma. Consistency of the test results across studies has not been systematically evaluated.

Objective: To assess the robustness of the prognostic value of the 31-GEP. Read More

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http://dx.doi.org/10.1016/j.jaad.2020.03.053DOI Listing

Performance of models predicting residual lymph node disease in melanoma patients following sentinel lymph node biopsy.

Am J Surg 2020 05 13;219(5):750-755. Epub 2020 Mar 13.

BC Cancer-Sindi Ahluwalia Hawkins Centre, Dept. of Surgical Oncology, 399 Royal Ave, Kelowna, BC, V1Y 5L3, Canada. Electronic address:

Background: Among melanoma patients with a tumor-positive sentinel node biopsy (SNB), approximately 20% harbor disease in non-sentinel nodes (nSN), as determined by a completion lymph node dissection (CLND). CLND lacks a survival benefit and has high morbidity. This study assesses predictive factors for nSN metastasis and validates five models predicting nSN metastasis. Read More

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http://dx.doi.org/10.1016/j.amjsurg.2020.02.059DOI Listing

Outcomes of Cartilage-Sparing Wide Local Excision for Primary Melanoma of the External Ear.

OTO Open 2020 Jan-Mar;4(1):2473974X20903124. Epub 2020 Jan 31.

Department of Otolaryngology, Massachusetts Eye and Ear, Boston, Massachusetts, USA.

Objective: To describe outcomes after cartilage-sparing wide local excision for primary melanoma of the external ear.

Study Design: Retrospective analysis of patients undergoing external ear melanoma excision using a cartilage-sparing approach at a university-based tertiary care center between 2010 and 2018.

Setting: University-based tertiary care center. Read More

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http://dx.doi.org/10.1177/2473974X20903124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065503PMC
January 2020

[Malignant melanoma].

Pathologe 2020 May;41(3):281-292

Klinik und Poliklinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum Essen, Hufelandstr. 55, 45147, Essen, Deutschland.

Malignant melanoma is an aggressive skin cancer that originates from cells of the melanocytic lineage and is associated with an invasive growth pattern and early spread. Besides endogenous risk factors such as fair skin type or genetic disposition for the formation of multiple nevi, exposure to ultraviolet light is the most important exogenous risk factor. Treatment of patients with primary tumors includes the complete excision of the primary lesion with appropriate safety margins and in patients with an increased risk of metastasis sentinel lymph node excision. Read More

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http://dx.doi.org/10.1007/s00292-020-00776-xDOI Listing

Relationship of patient age to tumor factors and outcomes among patients undergoing sentinel node biopsy for melanoma.

Am J Surg 2020 05 10;219(5):836-840. Epub 2020 Mar 10.

Department of Surgery, Division of Surgical Oncology, Oregon Health & Science University, Portland, OR, USA. Electronic address:

Introduction: Patient age has been intermittently associated with demographics and outcomes in cutaneous melanoma. We looked at the association of age and patient demographics, tumor features, and melanoma-related outcomes in patients undergoing sentinel lymph node (SLN) biopsy for melanoma.

Methods: We reviewed demographics (age, gender), tumor features (mean Breslow thickness, ulceration, SLN positivity rates), and outcomes (all-site relapse, progression to stage IV, death from melanoma, complications) from a university-based prospective database of 1633 patients. Read More

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http://dx.doi.org/10.1016/j.amjsurg.2020.03.013DOI Listing

Report on fluorescence lifetime imaging using multiphoton laser scanning microscopy targeting sentinel lymph node diagnostics.

J Biomed Opt 2020 Mar;25(7):1-8

University of Gothenburg, Biomedical Photonics Group, Department of Chemistry and Molecular Biology,, Sweden.

Significance: Sentinel lymph node (SLN) biopsy is an important method for metastasis staging in, e.g., patients with malignant melanoma. Read More

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http://dx.doi.org/10.1117/1.JBO.25.7.071204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070082PMC

Regional nodal metastasis and 5-year survival in patients with thin melanoma in Queensland: a population-based study.

ANZ J Surg 2020 04 12;90(4):503-507. Epub 2020 Mar 12.

Discipline of Surgery, The University of Queensland, Brisbane, Queensland, Australia.

Background: Optimal management of regional lymph nodes for thin cutaneous melanoma is uncertain. We evaluated regional lymph node involvement and 5-year melanoma-specific survival (MSS) in patients with thin (≤1 mm) primary melanoma.

Methods: Patients with a melanoma, American Joint Committee on Cancer Staging 8th Edition pT1a (<0. Read More

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http://dx.doi.org/10.1111/ans.15804DOI Listing

Efficacy of positron emission tomography and computed tomography in clinical staging of cutaneous malignant melanoma.

Dermatol Ther 2020 May 23;33(3):e13304. Epub 2020 Mar 23.

Department of Plastic Surgery, Başkent University, School of Medicine, Konya, Turkey.

Accurate staging is very important for determining the prognosis and appropriate treatment for malignant melanoma (MM). The aim of this study is to determine the effectiveness of positron emission tomography and computed tomography (PET/CT) imaging in staging MM. Patients diagnosed with MM who then underwent PET/CT metastasis before treatment were assessed retrospectively. Read More

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http://dx.doi.org/10.1111/dth.13304DOI Listing

Primary Cutaneous Clear Cell Sarcoma, Clinical Outcome With Sentinel Lymph Nodes Status.

Am J Clin Pathol 2020 May;153(6):799-810

Department of Pathology, Immunology and Laboratory Medicine, Rutgers New Jersey Medical School, Newark.

Objectives: Primary cutaneous clear cell sarcoma (PCS) is a rare malignancy and difficult to differentiate from melanoma. We investigated factors influencing survival and recurrence.

Methods: An institutional cancer registry and literature search were used for a retrospective study. Read More

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http://dx.doi.org/10.1093/ajcp/aqaa009DOI Listing

Identifying challenges to implementation of clinical practice guidelines for sentinel lymph node biopsy in patients with melanoma in Australia: protocol paper for a mixed methods study.

BMJ Open 2020 02 27;10(2):e032636. Epub 2020 Feb 27.

Australian Institute of Health Innovation, Macquarie University, Sydney, New South Wales, Australia.

Introduction: Sentinel lymph node biopsy (SLNB) is a diagnostic procedure developed in the 1990s. It is currently used to stage patients with primary cutaneous melanoma, provide prognostic information and guide management. The Australian Clinical Practice Guidelines state that SLNB should be considered for patients with cutaneous melanoma >1 mm in thickness (or >0. Read More

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http://dx.doi.org/10.1136/bmjopen-2019-032636DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7050375PMC
February 2020

Predictors of occult lymph node metastasis in cutaneous head and neck melanoma.

World J Otorhinolaryngol Head Neck Surg 2019 Dec 28;5(4):200-206. Epub 2019 Sep 28.

Department of Otolaryngology- Head and Neck Surgery, Medical University of South Carolina, Charleston, SC, USA.

Objective: To use the Surveillance, Epidemiology, and End Results (SEER) database to verify the findings of a recent National Cancer Database (NCDB) study that identified factors predicting occult nodal involvement in cutaneous head and neck melanoma (CHNM) while identifying additional predictors of occult nodal metastasis and comparing two distinct cancer databases.

Methods: Cases of CHNM in the SEER database diagnosed between 2004 and 2014 were identified. Demographic information and oncologic data were obtained. Read More

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http://dx.doi.org/10.1016/j.wjorl.2019.02.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7015849PMC
December 2019

Effect of delay between nuclear medicine scanning and sentinel node biopsy on outcome in patients with cutaneous melanoma.

Br J Surg 2020 May 19;107(6):669-676. Epub 2020 Feb 19.

Department of Surgery, Sahlgrenska University Hospital, Gothenburg, Sweden.

Background: Sentinel lymph node biopsy (SLNB) is an important staging tool for the management of melanoma. A multicentre study was done to validate previous findings that the timing of lymphoscintigraphy influences the accuracy of SLNB and patient outcomes, particularly survival.

Methods: Data were reviewed on patients undergoing SLNB for melanoma at three centres in the UK and Sweden, examining the effect of timing of SLNB after nuclear medicine scanning. Read More

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http://dx.doi.org/10.1002/bjs.11460DOI Listing

Evolution and outcomes of sentinel lymph node mapping in vulvar cancer.

Int J Gynecol Cancer 2020 03 18;30(3):383-386. Epub 2020 Feb 18.

Gynecology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York City, New York, USA.

Objectives: To characterize our institutional experience with sentinel lymph node (SLN) biopsy in patients with vulvar cancer. We describe the oncologic outcomes of these patients and the utilization of SLN detection techniques over time.

Methods: A retrospective analysis of all patients who underwent inguinofemoral SLN biopsy as part of their treatment for vulvar cancer at Memorial Sloan Kettering Cancer Center from January 1, 2000 to April 1, 2019. Read More

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http://dx.doi.org/10.1136/ijgc-2019-000936DOI Listing

Melanoma of the External Auditory Canal: A Review of Seven Cases at a Tertiary Care Referral Center.

Laryngoscope 2020 Feb 17. Epub 2020 Feb 17.

Department of Head and Neck Surgery, University of Texas MD Anderson Cancer Center, Houston, Texas.

Objectives/hypothesis: Examine the presentation and management characteristics of seven patients with melanoma of the external auditory canal (EAC).

Study Design: Retrospective case series and review of the relevant literature.

Methods: Records of seven patients from 2003 to 2017 with melanoma of the EAC were reviewed for characteristics of presentation, subsequent management, and outcomes. Read More

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http://dx.doi.org/10.1002/lary.28548DOI Listing
February 2020

Clinicopathological Features, Staging, and Current Approaches to Treatment in High-Risk Resectable Melanoma.

J Natl Cancer Inst 2020 Feb 15. Epub 2020 Feb 15.

Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

The incidence of melanoma in the United States has been increasing over the past several decades. Prognosis largely depends on disease stage, with 5-year melanoma-specific survival ranging from as high as 99% in patients with stage I disease to less than 10% for some patients with stage IV (distant metastatic) disease. Fortunately, in the last 5-10 years, there have been remarkable treatment advances for patients with high-risk resectable melanoma, including approval of targeted and immune checkpoint blockade therapies. Read More

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http://dx.doi.org/10.1093/jnci/djaa012DOI Listing
February 2020

Absolute and relative differential blood count predicts survival of AJCC stage I-II melanoma patients scheduled for sentinel lymph node biopsy.

Australas J Dermatol 2020 Feb 12. Epub 2020 Feb 12.

Department of Dermatology and Venereology, University Medical Center Tubingen, University Tubingen, Tubingen, Germany.

Background/objectives: Elevated neutrophil-to-lymphocyte ratio (NLR) in peripheral blood is associated with poor overall survival (OS) in metastatic melanoma patients receiving immunotherapy. However, the impact of peripheral blood cells in patients undergoing sentinel lymph node biopsy (SLNB) is still unclear. This study was intended to characterize the impact of peripheral blood leukocytic cells on overall survival (OS) in melanoma patients undergoing SLNB. Read More

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http://dx.doi.org/10.1111/ajd.13248DOI Listing
February 2020

Internal Pathology Review of Invasive Melanoma: An Academic Institution Experience.

J Surg Res 2020 Jun 7;250:97-101. Epub 2020 Feb 7.

Vanderbilt University Medical Center, Division of Surgical Oncology and Endocrine Surgery, Nashville, Tennessee. Electronic address:

Background: Prior studies of internal pathology review (IPR) for melanoma have shown that changes in the pathology analysis are common. How these changes impact clinical management of melanoma or how the margin status reports may modify has not been evaluated. Our goal was to determine what changes to staging and surgical management occurred after IPR of newly diagnosed melanomas and to determine how the final surgical pathology report may correlate with the IPR. Read More

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http://dx.doi.org/10.1016/j.jss.2019.12.044DOI Listing

Sentinel Lymph Node Biopsy in Head and Neck Melanoma: Long-term Outcomes, Prognostic Value, Accuracy, and Safety.

Otolaryngol Head Neck Surg 2020 04 11;162(4):520-529. Epub 2020 Feb 11.

Department of Otolaryngology-Head and Neck Surgery, Michigan Medicine, Ann Arbor, Michigan, USA.

Objective: To evaluate the long-term outcomes of sentinel lymph node biopsy (SLNB) for head and neck cutaneous melanoma (HNCM).

Study Design: Retrospective cohort study.

Setting: Tertiary academic medical center. Read More

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http://dx.doi.org/10.1177/0194599819899934DOI Listing
April 2020
1.721 Impact Factor

Does the time interval between sentinel lymph node biopsy and completion lymph node dissection affect outcome in malignant melanoma? A retrospective cohort study.

Int J Surg 2020 Mar 7;75:160-164. Epub 2020 Feb 7.

Research Unit for Tissue Regeneration, Repair and Reconstruction, Division of Plastic, Aesthetic and Reconstructive Surgery Graz, Department of Surgery, Medical University of Graz, Auenbruggerplatz 29, A-8036, Graz, Austria. Electronic address:

Nodal clearance was recommended after positive sentinel lymph node biopsy (SLNB) despite further metastases to the regional lymph node basin being found in only 6-21% in the literature. This retrospective study was conducted to determine the role of the time interval between excision of primary melanoma and confirmed metastasis in the sentinel lymph node biopsy as well as the one between positive sentinel lymph node biopsy (SLNB-positive patients) and subsequent completion lymph node dissection (CLND) on the presence of metastases. The monocentric analysis included 121 patients with a history of completion lymph node dissection after positive SLNB from January 2005 to October 2013. Read More

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http://dx.doi.org/10.1016/j.ijsu.2020.01.146DOI Listing