2,459 results match your criteria Sentinel Lymph Node Biopsy in Patients With Melanoma


Disparities in the management of cutaneous malignant melanoma. A population-based high-resolution study.

Eur J Cancer Care (Engl) 2019 Apr 16:e13043. Epub 2019 Apr 16.

Navarra Public Health Institute - IdiSNA, Pamplona, Spain.

Population-based cancer registry data from three Spanish areas were used to assess the patterns of care and adherence to guidelines for cutaneous malignant melanoma. We included 934 cases diagnosed in 2009-2013. Completeness of the pathology reports, imaging for detecting distant metastasis and the use of sentinel lymph node biopsy (SLNB) were analysed. Read More

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http://dx.doi.org/10.1111/ecc.13043DOI Listing

Complications and Sequelae After Sentinel Lymph Node Biopsy in Melanoma: A Retrospective Cohort Study.

Actas Dermosifiliogr 2019 Apr 11. Epub 2019 Apr 11.

Servicio de Dermatología, Complexo Hospitalario Universitario de Vigo, Vigo, Pontevedra, España. Electronic address:

Background And Objective: Sentinel lymph node (SLN) biopsy is a staging, not a therapeutic, procedure. The benefits of SLN biopsy have been more modest than expected and could be outweighed by the risks, which remain unclear. The aim of this study was to describe complications and sequelae observed in patients with melanoma who underwent routine SLN biopsy at our hospital. Read More

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http://dx.doi.org/10.1016/j.ad.2019.01.003DOI Listing

Wide local excision prior to sentinel lymph node biopsy for primary melanoma of the head and neck.

Int J Dermatol 2019 Apr 10. Epub 2019 Apr 10.

Department of Otorhinolaryngology-Head and Neck Surgery, Mayo Clinic School of Medicine, Rochester, MN, USA.

Background: Previous wide local excision prior to sentinel lymph node biopsy (SLNB) may have the potential to disrupt lymphatic channels, thus incorrectly identifying the sentinel node. The purpose of this study was to investigate: (1) regional recurrence rates of prior wide local excision compared to other biopsy techniques and (2) survival outcomes in patients with melanoma of the head and neck.

Methods: Between the years 2000 and 2016, 391 cases were reviewed with a median follow-up time of 30 months in a large tertiary care center. Read More

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http://dx.doi.org/10.1111/ijd.14435DOI Listing

Observational approach on regional lymph node in cutaneous melanomas of extremities.

Radiat Oncol J 2019 Mar 31;37(1):51-59. Epub 2019 Mar 31.

Department of Radiation Oncology, Seoul National University Bundang Hospital, Seongnam, Korea.

Purpose: We evaluated failure pattern and treatment outcomes of observational approach on regional lymph node (LN) in cutaneous melanoma of extremities and sought to find clinico-pathologic factors related to LN metastases.

Material And Methods: We retrospectively reviewed 73 patients with cutaneous melanoma of extremities between 2005 and 2016. If preoperative 18-F-fluorodeoxyglucose (FDG)-positron emission tomography/computed tomography (PET/CT) findings were non-specific for regional LNs, surgical resection of primary tumors with adequate margins was performed without sentinel lymph node biopsy (SLNB) and/or complete lymph node dissection (CLND), irrespective of tumor thickness or size. Read More

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http://e-roj.org/journal/view.php?doi=10.3857/roj.2018.00507
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http://dx.doi.org/10.3857/roj.2018.00507DOI Listing
March 2019
5 Reads

Promoter Mutations are Associated with Visceral Spreading in Melanoma of the Trunk.

Cancers (Basel) 2019 Mar 30;11(4). Epub 2019 Mar 30.

Department of Medical Sciences, Dermatology Unit, University of Torino, 10126 Torino, Italy.

Survival predictions are currently determined on the basis of mutations, even though promoter mutations have been recently associated with a poor prognosis in stage I-II melanomas. Usually, it is not recommended to perform a mutational test on primary melanoma, as the results do not always reflect the mutational status of metastases. In particular, trunk melanomas have been reported to have an unfavourable prognosis. Read More

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http://dx.doi.org/10.3390/cancers11040452DOI Listing

Clinical importance and surgical management of sentinel lymph nodes in the popliteal fossa of melanoma patients.

Eur J Surg Oncol 2019 Mar 23. Epub 2019 Mar 23.

Melanoma Institute Australia, The University of Sydney, Sydney, Australia; Faculty of Medicine and Health, The University of Sydney, Sydney, Australia; Department of Melanoma and Surgical Oncology, Royal Prince Alfred Hospital, Sydney, Australia.

Background And Purpose: Patients with a primary melanoma below the knee may have lymphatic drainage to a sentinel node (SN) in the popliteal fossa. The purpose of this study was to analyze lymphatic drainage to this site and to describe clinical features and surgical management of SNs in the popliteal fossa.

Methods: Patients with a primary melanoma below the knee presenting to Melanoma Institute Australia between 1992 and 2013 were analyzed. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07487983193035
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http://dx.doi.org/10.1016/j.ejso.2019.03.026DOI Listing
March 2019
1 Read

Medical Options for the Adjuvant Treatment and Management of Pediatric Melanoma.

Paediatr Drugs 2019 Mar 28. Epub 2019 Mar 28.

School of Medicine, Harvard University, Boston, MA, USA.

Although melanoma is a rare diagnosis in the pediatric population, advances in the management of adults with melanoma offer the prospect of promising therapeutic options for children. At this time, medical management is not considered curative but may reduce the risk of recurrence or prolong survival. Surgical management remains the mainstay of treatment. Read More

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http://dx.doi.org/10.1007/s40272-019-00326-wDOI Listing
March 2019
1 Read

Sentinel Lymph Node Biopsy in Patients With Acral Melanoma: Analysis of 201 Cases From the Brazilian National Cancer Institute.

Dermatol Surg 2019 Mar 19. Epub 2019 Mar 19.

Department of Epidemiology and Quantitative Methods in Health, Oswaldo Cruz Foundation, National School of Public Health, Rio de Janeiro, Brazil.

Background: Sentinel lymph node biopsy (SLNB) is the most powerful predictor of relapse-free survival (RFS) and overall survival (OS). No studies have evaluated survival of acral melanoma (AM) undergoing SLNB in Brazil.

Objective: The objective of this study was to investigate the factors associated with the survival of patients with AM undergoing SLNB. Read More

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http://dx.doi.org/10.1097/DSS.0000000000001785DOI Listing
March 2019
1 Read

Does Wide Excisional Biopsy in Skin Cancer Prevent Finding The Real Sentinel Lymph Node?

J Invest Surg 2019 Mar 20:1-7. Epub 2019 Mar 20.

a Plastic, Reconstructive and Aesthetic Surgery Department , University of Health Sciences Sisli Hamidiye Etfal Training and Research Hospital , Istanbul , Turkey.

Purpose/Aim: The presence of nodal metastasis is an important prognostic factor for malignant melanoma and causes a 50% decrease in survival. Patients found not to have lymph node metastasis as a result of sentinel lymph node biopsy but develop regional lymph node metastasis in the follow-up period are called false negative sentinel. The hypothesis of this study was that excisional biopsy in patients with large lesions may change the lymphatic pathway and therefore cause false negative results. Read More

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http://dx.doi.org/10.1080/08941939.2018.1559898DOI Listing

Does sentinel lymph node status have prognostic significance in patients with acral lentiginous melanoma?

J Surg Oncol 2019 Mar 18. Epub 2019 Mar 18.

Division of Surgical Oncology, Department of Surgery, Oregon Health and Science University, Portland, Oregon.

Background: The prognostic benefit of sentinel lymph node biopsy (SLNB) and factors predictive of survival specifically in patients with acral lentiginous melanoma (ALM) are unknown.

Methods: The SEER database was queried for ALM cases that underwent SLNB from 1998 to 2013. Clinicopathological factors were correlated with SLN status, overall survival (OS), and melanoma-specific survival (MSS). Read More

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http://dx.doi.org/10.1002/jso.25445DOI Listing
March 2019
1 Read

Completion lymphadenectomy for a positive sentinel node biopsy in melanoma patients is not associated with a survival benefit.

J Surg Oncol 2019 Mar 18. Epub 2019 Mar 18.

Division of Surgical Oncology, Oregon Health & Science University, Portland, Oregon.

Background: Completion lymph node dissection (CLND) for sentinel lymph node (SLN) disease in melanoma patients is debated. We evaluated the impact of CLND on survival and assessed for predictors of nonsentinel node metastasis (positive CLND).

Methods: Positive SLN melanoma patients were retrospectively identified in the Sentinel Lymph Node Working Group database. Read More

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http://dx.doi.org/10.1002/jso.25444DOI Listing

Clinical Value of Single-photon Emission Computed Tomography Combined With Computed Tomography for Sentinel Lymph Node Identification in Melanoma.

Ann Plast Surg 2019 Apr;82(4S Suppl 3):S192-S194

From the Section of Plastic and Reconstructive Surgery, Department of Surgery, Yale New Haven Hospital, New Haven, CT.

Introduction: Melanoma is the deadliest form of skin cancer and has the ability to metastasize widely. Accurate diagnosis of sentinel lymph nodes (SLN) is crucial to its management. The gold standard for SLN identification is planar lymphoscintigraphy. Read More

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http://dx.doi.org/10.1097/SAP.0000000000001895DOI Listing
April 2019
4 Reads

Axillary sentinel node biopsy in prone position for melanomas on the upper back or nape.

J Plast Surg Hand Surg 2019 Mar 8:1-6. Epub 2019 Mar 8.

a Department of Dermatology, Venereology and Allergology , University Medical Center Göttingen , Göttingen , Germany.

In patients with melanomas on the upper back or nape, axillary sentinel lymph node (SLN) biopsy (SLNB), when performed in the traditional supine position, is often disturbed by scattered radiation emitted from the primary tumor site. The results from the present study suggestthat axillary SLNB performed in the prone position can solve this problem. We compared two consecutive groups of patients with melanomas of the dorsal trunk or nape who received axillary SLNB performed either in the supine (n = 119) or in the prone position (n = 130). Read More

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http://dx.doi.org/10.1080/2000656X.2019.1582427DOI Listing
March 2019
1 Read

Early Melanoma Nodal Positivity and Biopsy Rates Before and After Implementation of the 7th Edition of the AJCC Cancer Staging Manual.

JAMA Dermatol 2019 Mar 6. Epub 2019 Mar 6.

Division of Surgical Oncology and Endocrine Surgery, Vanderbilt University Medical Center, Nashville, Tennessee.

Importance: There has been a continued increase in the incidence of newly diagnosed melanomas, most of which are T1 melanomas. The associations between changes in tumor staging, implemented with the 7th edition of the AJCC Cancer Staging Manual (AJCC 7), and sentinel lymph node biopsy rates and nodal positivity rates remain to be seen.

Objective: To evaluate the change that the implementation of the AJCC 7 had on staging criteria and the distribution of thin melanomas requiring nodal surgery and nodal positivity rates. Read More

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http://archderm.jamanetwork.com/article.aspx?doi=10.1001/jam
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http://dx.doi.org/10.1001/jamadermatol.2018.5902DOI Listing
March 2019
4 Reads

Prospective cohort study of ultrasound surveillance of regional lymph nodes in patients with intermediate-risk cutaneous melanoma.

Br J Surg 2019 May 28;106(6):729-734. Epub 2019 Feb 28.

Skin Cancer Unit, Royal Marsden Hospital NHS Foundation Trust, London, UK.

Background: For patients with intermediate-thickness melanoma, surveillance of regional lymph node basins by clinical examination alone has been reported to result in a larger number of lymph nodes involved by melanoma than if patients had initial sentinel node biopsy and completion dissection. This may result in worse regional control. A prospective study of both regular clinical examination and ultrasound surveillance was conducted to assess the effectiveness of these modalities. Read More

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http://doi.wiley.com/10.1002/bjs.11112
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http://dx.doi.org/10.1002/bjs.11112DOI Listing
May 2019
2 Reads

Multiple lymphatic-venous anastomoses in reducing the risk of lymphedema in melanoma patients undergoing complete lymph node dissection. A retrospective case-control study.

J Plast Reconstr Aesthet Surg 2019 Apr 10;72(4):642-648. Epub 2019 Feb 10.

Section of Plastic and Reconstructive Surgery, Department of Emergency and Organ Transplantation, University of Bari, 11, Piazza Giulio Cesare, Bari 70124, Italy.

Background: Sentinel lymph node biopsy (SLNB) is an indispensable surgical procedure in staging and management of intermediate-to-thick melanomas. Although recent studies have demonstrated that complete lymph node dissection (CLND) does not improve 3-year specific survival, its utility in increasing the disease-free period and the control of local disease remains confirmed. The most frequent complication related to CLND is lymphedema, which may affect up to 20% of patients undergoing CLND. Read More

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http://dx.doi.org/10.1016/j.bjps.2019.01.023DOI Listing
April 2019
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Enhancing the prognostic role of melanoma sentinel lymph nodes through microscopic tumour burden characterization: clinical usefulness in patients who do not undergo complete lymph node dissection.

Melanoma Res 2019 04;29(2):163-171

Department of Plastic and Reconstructive Surgery, Regional Melanoma Referral Center and Melanoma & Skin Cancer Unit.

This study aimed to investigate the sentinel lymph node (SLN) tumour burden to predict the non-SLN positivity rate and the survival of melanoma patients to evaluate whether SLN microstaging could predict the prognosis, similar to what is currently performed by examining the lymph nodes excised by complete lymph node dissection. Of 1130 consecutive melanoma patients who underwent SLN biopsy, 226 were tumour-positive and 204 were included in this study. SLN metastases were classified on the basis of dimensional (Rotterdam) and topographic (Dewar) criteria either separately or combined. Read More

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http://dx.doi.org/10.1097/CMR.0000000000000481DOI Listing
April 2019
2 Reads

Efficacy and reproducibility of lymphatics mapping technique with sentinel lymph node biopsy in melanoma.

Cir Cir 2019 ;87(2):241-246

Hospital Privado Universitario de Córdoba, Córdoba, Argentina.

Introduction: The study of the Sentinel Lymph Node (SLN) in Melanoma is a procedure that aims the identification of the first node to which the affected cutaneous sector drains in order to avoid unnecessary lymphadenectomies. The present study documents the frequency of identification of SLN; the relationship between positive SLN (PSLN) and recurrence, between the Breslow index (BI) and PSLN, and between BI and disease recurrence.

Method: We analyzed the records of 148 patients with melanoma stages I and II undergoing lymphatic mapping and GC biopsy from 1999 to 2017 in a third level institution in Córdoba, Argentina. Read More

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http://www.cirugiaycirujanos.com/frame_esp.php?id=135
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http://dx.doi.org/10.24875/CIRU.18000439DOI Listing
January 2019
2 Reads

Association between tumor-infiltrating lymphocytes and sentinel lymph node positivity in thin melanoma.

An Bras Dermatol 2019 Jan-Feb;94(1):47-51

Service of Dermatology, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre (RS), Brazil.

Background: Sentinel lymph node biopsy in thin invasive primary cutaneous melanoma (up to 1mm thick) is a controversial subject. The presence of tumor-infiltrating lymphocytes could be a factor to be considered in the decision to perform this procedure.

Objective: To evaluate the association between the presence of tumor-infiltrating lymphocytes and lymph node metastases caused by thin primary cutaneous melanoma. Read More

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http://dx.doi.org/10.1590/abd1806-4841.20197414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360962PMC
February 2019
2 Reads

Trends in Sentinel Lymph Node Biopsy Enactment for Cutaneous Melanoma.

Ann Surg Oncol 2019 May 4;26(5):1494-1502. Epub 2019 Feb 4.

Department of Pathology, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands.

Background: Over recent years, sentinel lymph node biopsy (SLNB) recommendations in guidelines for cutaneous melanoma have changed considerably. We aimed to assess trends in enactment of SLNB to evaluate to what extent guidelines were adhered to, and to identify clinical and pathological determinants of (non-)adherence.

Methods: Clinicopathological data from the Dutch nationwide network and registry of histopathology and cytopathology were retrieved from patients diagnosed with primary cutaneous melanoma in The Netherlands between 2003 and 2014. Read More

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http://link.springer.com/10.1245/s10434-019-07204-2
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http://dx.doi.org/10.1245/s10434-019-07204-2DOI Listing
May 2019
8 Reads

Postbiopsy Pigmentation is Prognostic in Head and Neck Melanoma.

Ann Surg Oncol 2019 Apr 31;26(4):1046-1054. Epub 2019 Jan 31.

Department of Surgery, Gastrointestinal Tumor and Endocrine Surgery, University of Colorado School of Medicine, Aurora, CO, USA.

Purpose: To assess postbiopsy pigmentation (PBP) as a prognostic feature in patients with cutaneous head and neck (H&N) melanoma.

Methods: Retrospective review of patients undergoing sentinel lymph node biopsy (SLNB) for H&N melanoma (1998-2018). PBP was defined as visible remaining pigment at the scar or biopsy site that was documented on physical exam by both a medical oncologist and a surgeon at initial consultation. Read More

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http://link.springer.com/10.1245/s10434-019-07185-2
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http://dx.doi.org/10.1245/s10434-019-07185-2DOI Listing
April 2019
7 Reads

Natural history of pain associated with melanoma surgery.

Pain Rep 2018 Nov 19;3(6):e689. Epub 2018 Oct 19.

California Pacific Medical Center Research Institute, San Francisco, CA, USA.

Introduction: After excision of a primary malignant melanoma (MM), treatment of stage IB or higher MM consists of sentinel lymph node biopsy (SLNB). If malignant cells are identified, a complete lymph node dissection (CLND) can be performed.

Objective: To determine the natural history of pain and sensory changes after MM surgery. Read More

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http://dx.doi.org/10.1097/PR9.0000000000000689DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344134PMC
November 2018
12 Reads

Performance of a 31-gene expression profile test in cutaneous melanomas of the head and neck.

Head Neck 2019 Apr 29;41(4):871-879. Epub 2019 Jan 29.

Division of Surgical Oncology, Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon.

Background: We report the performance of a gene expression profile test to classify the recurrence risk of cutaneous melanoma tumors of the head and neck as low-risk Class 1 or high-risk Class 2.

Methods: Of note, 157 primary head and neck cutaneous melanoma tumors were identified. Survival analyses were performed using Kaplan-Meier and Cox methods. Read More

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http://doi.wiley.com/10.1002/hed.25473
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http://dx.doi.org/10.1002/hed.25473DOI Listing
April 2019
14 Reads

Guidance of sentinel lymph node biopsy decisions in patients with T1-T2 melanoma using gene expression profiling.

Future Oncol 2019 Apr 29;15(11):1207-1217. Epub 2019 Jan 29.

Division of Surgical Oncology, Department of Surgery, The University of Tennessee Health Science Center, Memphis, TN 38163, USA.

Aim: Can gene expression profiling be used to identify patients with T1-T2 melanoma at low risk for sentinel lymph node (SLN) positivity?

Patients & Methods: Bioinformatics modeling determined a population in which a 31-gene expression profile test predicted <5% SLN positivity. Multicenter, prospectively-tested (n = 1421) and retrospective (n = 690) cohorts were used for validation and outcomes, respectively.

Results: Patients 55-64 years and ≥65 years with a class 1A (low-risk) profile had SLN positivity rates of 4. Read More

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https://www.futuremedicine.com/doi/10.2217/fon-2018-0912
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http://dx.doi.org/10.2217/fon-2018-0912DOI Listing
April 2019
4 Reads

Should Sentinel Lymph Node Biopsy Be Performed for All T1b Melanomas in the New 8 Edition American Joint Committee on Cancer Staging System?

J Am Coll Surg 2019 Apr 17;228(4):466-472. Epub 2019 Jan 17.

Hiram C Polk Jr, MD, Department of Surgery, University of Louisville, Louisville, KY.

Background: In the 8 edition of the American Joint Committee on Cancer melanoma staging system, the T1b category has been redefined based solely on thickness and ulceration. National Comprehensive Cancer Network guidelines recommend consideration of sentinel lymph node biopsy (SLNB) for all patients with T1b melanomas (0.8 to 1. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10727515193004
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http://dx.doi.org/10.1016/j.jamcollsurg.2018.12.030DOI Listing
April 2019
8 Reads

Eye-Sparing Treatment for Diffuse Invasive Conjunctival Melanoma.

Ocul Oncol Pathol 2018 Jun 1;4(4):261-266. Epub 2018 Feb 1.

Department of Ophthalmology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.

The management of patients with diffuse invasive conjunctival melanoma focuses on local tumor control and screening for metastasis. Despite the lack of consensus on the benefit of sentinel lymph node biopsy for these neoplasms, the information obtained by histopathology is useful for tumor staging and treatment planning. Due to the lack of evidence of survival improvement, orbital exenteration is being performed with diminishing frequency. Read More

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http://dx.doi.org/10.1159/000485978DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322084PMC
June 2018
2 Reads

Clinical implications of the eighth edition of the American Joint Committee on Cancer melanoma staging.

J Surg Oncol 2019 Jan 21;119(2):168-174. Epub 2018 Dec 21.

Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.

The new edition of the American Joint Committee on Cancer staging system for melanoma builds on the foundation of prior editions but has several important improvements. The availability of regional nodal staging using sentinel lymph node biopsy (with subsequent follow-up) has resulted in more accurate prognostication for patients and clinicians. This facilitates identification of those at higher risk for recurrence, and allows for the appropriate selection of patients for new adjuvant therapy and clinical trials. Read More

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http://doi.wiley.com/10.1002/jso.25343
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http://dx.doi.org/10.1002/jso.25343DOI Listing
January 2019
12 Reads

Subungual Melanoma of the Hand.

Ann Surg Oncol 2019 Apr 18;26(4):1035-1043. Epub 2018 Dec 18.

Melanoma Institute Australia, Sydney, NSW, Australia.

Background: The diagnosis of subungual melanoma (SUM) can be challenging and SUMs generally have a worse prognosis than melanomas arising elsewhere. Due to their rarity, the evidence to guide management is limited. This study sought to identify clinicopathological features predictive of outcome and to provide guidelines for management. Read More

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http://dx.doi.org/10.1245/s10434-018-07094-wDOI Listing
April 2019
1 Read

Current controversies in early-stage melanoma: Questions on incidence, screening, and histologic regression.

J Am Acad Dermatol 2019 01;80(1):1-12

Department of Dermatology, University of Utah Health Sciences Center, Salt Lake City, Utah; Huntsman Cancer Institute, University of Utah Health Sciences Center, Salt Lake City, Utah. Electronic address:

In the first article in this continuing medical education series we review controversies and uncertainties relating to the epidemiology and initial diagnosis of localized cutaneous melanoma (ie, stage 0, I, or II). Many of these issues are unsettled because of conflicting evidence. Melanoma incidence appears to be increasing, yet its basis has not been fully explained. Read More

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http://dx.doi.org/10.1016/j.jaad.2018.03.053DOI Listing
January 2019
15 Reads

Receipt of sentinel lymph node biopsy for thin melanoma is associated with distance traveled for care.

J Surg Oncol 2019 Jan 3;119(1):148-155. Epub 2018 Dec 3.

Department of Surgery, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire.

Background: Sentinel lymph node biopsy (SLNB) is not routinely recommended for thin melanoma. However, it is considered when high-risk features, clinicopathological, or sociodemographic, are present. It was our objective to evaluate the impact of travel distance on decision-making for SLNB in thin melanoma. Read More

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http://dx.doi.org/10.1002/jso.25314DOI Listing
January 2019
2 Reads

Lack of survival benefit in sentinel lymph node-positive melanoma with immediate complete lymphadenectomy - a review.

J Dtsch Dermatol Ges 2019 Jan 3;17(1):7-13. Epub 2018 Dec 3.

Centre for Dermato-oncology, University Department of Dermatology, Eberhard Karls University, Tübingen, Germany.

For decades, melanoma surgery has been guided by the Halstedian concept of stepwise metastasis, first into the lymph nodes and subsequently to distant sites. Early complete lymph node dissection (CLND) was therefore recommended in order to improve survival. Four large prospective randomized trials failed to show any survival benefit of CLND in comparison to observation alone. Read More

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http://dx.doi.org/10.1111/ddg.13707DOI Listing
January 2019
1 Read

Consecutive Case Series of Melanoma Sentinel Node Biopsy for Lymphoseek Compared to Sulfur Colloids.

J Surg Res 2019 Jan 23;233:149-153. Epub 2018 Aug 23.

Department of Surgery, Sidney Kimmel Medical College, Thomas Jefferson University, Surgery, Philadelphia, Pennsylvania. Electronic address:

Background: Sentinel lymph node biopsy (SLNB) is an important adjunct in the staging of patients with melanoma. Preoperative lymphoscintigraphy with radiolabeled isotopes is essential to localize sentinel nodes for removal. Our study compared the effectiveness of Lymphoseek to standard sulfur colloids in patients with melanoma undergoing SLNB. Read More

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http://dx.doi.org/10.1016/j.jss.2018.07.042DOI Listing
January 2019
13 Reads

Management Decisions Made by Physician Assistants and Nurse Practitioners in Cutaneous Malignant Melanoma Patients: Impact of a 31-Gene Expression Profile Test

J Drugs Dermatol 2018 11;17(11):1220-1223

Importance: The 31 gene-expression profiling test (31-GEP) has been shown to provide useful prognostic information in patients with cutaneous melanoma. The test dichotomizes patients into lower risk (Class 1) or higher risk (Class 2) for melanoma metastasis. Previous studies have demonstrated the clinical utility of the test in impacting dermatologists’ management decisions. Read More

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November 2018
17 Reads

Management of Regional Lymph Nodes in Patients with Merkel Cell Carcinoma Following a Positive Sentinel Node Biopsy: Less May be More, But is Either Enough?

Ann Surg Oncol 2019 Feb 27;26(2):315-317. Epub 2018 Nov 27.

Faculty of Medicine and Health Sciences, The University of Sydney, Sydney, NSW, Australia.

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http://dx.doi.org/10.1245/s10434-018-7076-3DOI Listing
February 2019
3 Reads

Current management of regional lymph nodes in patients with melanoma.

J Surg Oncol 2019 Jan 27;119(2):200-207. Epub 2018 Nov 27.

Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY.

The publication of recent randomized trials has prompted a significant shift in both our understanding and the management of patients with melanoma. Here, the current management of the regional lymph nodes in patients with melanoma is discussed. This review focuses on selection for sentinel lymph node biopsy, management of the positive sentinel node, management of the clinically positive node, and the controversy over the therapeutic value of early nodal intervention. Read More

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http://dx.doi.org/10.1002/jso.25316DOI Listing
January 2019
1 Read

Time to reconsider the role of sentinel lymph node biopsy in melanoma.

J Am Acad Dermatol 2019 Apr 22;80(4):1168-1171. Epub 2018 Nov 22.

Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.

The Multicenter Selective Lymphadenectomy Trials indicate that there are no overall or melanoma-specific survival advantages to performing sentinel lymph node biopsy (SLNB) followed by immediate completion lymph node dissection compared with wide excision and observation for patients with positive sentinel nodes. These results make SLNB solely a staging procedure. The role of SLNB in the management of patients with melanoma deserves reappraisal. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01909622183295
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http://dx.doi.org/10.1016/j.jaad.2018.11.026DOI Listing
April 2019
11 Reads

Defective levels of both circulating dendritic cells and T-regulatory cells correlate with risk of recurrence in cutaneous melanoma.

Clin Transl Oncol 2018 Nov 23. Epub 2018 Nov 23.

Section of Oncology, Department of Biomedical Sciences and Clinical Oncology, University of Bari 'Aldo Moro', P.za Giulio Cesare, 11, 70124, Bari, Italy.

Background: Immune markers in the peripheral blood of melanoma patients provide useful information for clinical management although there is poor consensus on circulating cells which could putatively reflect the disease activity and play a prognostic role. Here, we investigated both dendritic cells (DCs) and T-regulatory cells (Tregs).

Methods: The number of DC subsets as myeloid (m) and plasmacytoid was measured by flowcytometry in 113 melanoma patients in different clinical stages and correlated with the disease activity to evaluate the recurrence free survival (RFS) calculated as difference between baseline and post-surgical values in relation to the criteria for the melanoma staging, as primary tumor removal, sentinel lymph node biopsy and completion of lymph node dissection. Read More

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http://dx.doi.org/10.1007/s12094-018-1993-2DOI Listing
November 2018
11 Reads

Clinical features and outcomes of spitzoid proliferations in children and adolescents.

Br J Dermatol 2018 Nov 22. Epub 2018 Nov 22.

Harvard Medical School, Boston, MA, 02115, U.S.A.

Background: Spitzoid proliferations range from Spitz naevi to melanomas. There are few studies describing clinical features and outcomes in the paediatric population.

Objectives: To determine the clinical features and outcomes of a large paediatric cohort with histopathologically confirmed Spitz tumours. Read More

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http://dx.doi.org/10.1111/bjd.17450DOI Listing
November 2018
11 Reads

Updates in Melanoma.

Dermatol Clin 2019 Jan;37(1):73-82

Department of Dermatology, Dermatology and Plastic Surgery Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Desk A61, Cleveland, OH 44195, USA. Electronic address:

Skin cancer is reaching epidemic levels in the United States. Recent advances in the understanding of the pathophysiology of melanoma have allowed improved risk stratification in the revised American Joint Committee on Cancer (AJCC) criteria, new tests to capture patients at higher risk than their stage may indicate, and new treatments to offer hope and cures to patients with advanced disease. Read More

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http://dx.doi.org/10.1016/j.det.2018.08.003DOI Listing
January 2019
13 Reads

Validation of a Nomogram for Non-sentinel Node Positivity in Melanoma Patients, and Its Clinical Implications: A Brazilian-Dutch Study.

Ann Surg Oncol 2019 Feb 19;26(2):395-405. Epub 2018 Nov 19.

Department of Surgical Oncology, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.

Background: Non-sentinel node (NSN) positivity impacts the prognosis of melanoma patients; however, the benefits of completion lymph node dissection in patients with positive sentinel nodes (SNs) are limited.

Objective: We aimed to present a predictive nomogram for NSN positivity in melanoma patients with a positive SN biopsy.

Methods: This retrospective analysis from patients who underwent SN biopsy in a Brazilian institution from 2000 to 2015 was used for the construction and internal validation of the nomogram. Read More

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http://dx.doi.org/10.1245/s10434-018-7038-9DOI Listing
February 2019
16 Reads

Sentinel lymph node imaging in urologic oncology.

Transl Androl Urol 2018 Oct;7(5):887-902

Molecular Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

Lymph node (LN) metastases in urological malignancies correlate with poor oncological outcomes. Accurate LN staging is of great importance since patients can benefit from an optimal staging, accordingly aligned therapy and more radical treatments. Current conventional cross-sectional imaging modalities [e. Read More

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http://tau.amegroups.com/article/view/21133/21414
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http://dx.doi.org/10.21037/tau.2018.08.23DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212622PMC
October 2018
35 Reads

Prognostic impact of regression in patients with primary cutaneous melanoma >1 mm in thickness.

J Am Acad Dermatol 2019 Jan 14;80(1):99-105.e5. Epub 2018 Nov 14.

Unit of Medical Oncology, Papa Giovanni XXIII Hospital, Bergamo, Italy. Electronic address:

Background: The impact of histologic regression on sentinel lymph node biopsy (SLNB) status and on clinical outcome is uncertain.

Objective: To investigate whether and to what extent regression <75% is able to predict SLNB status and clinical outcome of patients with melanoma >1-mm thick.

Methods: The study included patients with diagnoses given at 4 centers of the Italian Melanoma Intergroup. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01909622183221
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http://dx.doi.org/10.1016/j.jaad.2018.06.054DOI Listing
January 2019
18 Reads
4.450 Impact Factor

Microsatellitosis in Patients with Melanoma.

Ann Surg Oncol 2019 Jan 12;26(1):33-41. Epub 2018 Nov 12.

Moffitt Cancer Center, Tampa, FL, USA.

Background: Microsatellitosis (mS) in melanoma has been considered a marker of unfavorable tumor biology, leading to the current American Joint Committee on Cancer staging of IIIB/C/D disease, despite few investigative studies of this entity limited by the small sample sizes and incomplete nodal microstaging. We sought to better characterize outcomes and prognostic factors in a multi-institutional cohort of patients with mS and nodal microstaging.

Methods: The Sentinel Lymph Node Working Group cohort included 414 mS patients who underwent sentinel lymph node (SLN) biopsy. Read More

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http://dx.doi.org/10.1245/s10434-018-7006-4DOI Listing
January 2019
27 Reads

The long-term prognostic impact of sentinel lymph node biopsy in patients with primary cutaneous melanoma: a prospective study with 10-year follow-up.

Ann Surg Treat Res 2018 Nov 25;95(5):286-296. Epub 2018 Oct 25.

Department of Surgery and Department of Morphology, Surgery and Experimental Medicine, S. Anna University Hospital and University of Ferrara, Ferrara, Italy.

Purpose: Sentinel lymph node (SLN) biopsy (SLNB) is widely accepted for staging of melanoma patients. It has been shown that clinico-pathological features such as Breslow thickness, ulceration, age, and sex are better predictors of relapse and survival than SLN status alone. The aims of this study were to evaluate the long-term (10-year) prognostic impact of SLNB and to determine predictive factors associated with SLN metastasis, relapse, and melanoma specific mortality (MSM). Read More

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https://synapse.koreamed.org/DOIx.php?id=10.4174/astr.2018.9
Publisher Site
http://dx.doi.org/10.4174/astr.2018.95.5.286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204324PMC
November 2018
15 Reads

Risk Factors for Regional and Systemic Metastases in Patients with Sentinel Lymph Node-negative Melanoma.

Anticancer Res 2018 Nov;38(11):6571-6577

Department of Surgery, University Hospital Erlangen, Friedrich Alexander University Erlangen-Nürnberg (FAU), Erlangen, Germany.

Background: Sentinel lymph node status is a strong prognostic factor in melanoma. However, up to 21% of sentinel lymph node-negative patients develop locoregional and distant metastases during follow-up.

Aim: To analyze risk factors for locoregional and distant metastasis in patients with sentinel lymph node-negative melanoma. Read More

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http://ar.iiarjournals.org/lookup/doi/10.21873/anticanres.13
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http://dx.doi.org/10.21873/anticanres.13024DOI Listing
November 2018
15 Reads

A nomogram to identify high-risk melanoma patients with a negative sentinel lymph node biopsy.

J Am Acad Dermatol 2019 Mar 2;80(3):722-726. Epub 2018 Nov 2.

Skin Cancer Department, AC Camargo Cancer Center, São Paulo, Brazil.

Background: Melanoma patients with negative nodes after sentinel lymph node biopsy are a heterogeneous group. Current guidelines fail to adequately stratify surveillance and treatment for this group. Also, there is scarce data on adjuvant treatments for these patients. Read More

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http://dx.doi.org/10.1016/j.jaad.2018.10.060DOI Listing
March 2019
18 Reads

Guidelines of care for the management of primary cutaneous melanoma.

J Am Acad Dermatol 2019 01 1;80(1):208-250. Epub 2018 Nov 1.

American Academy of Dermatology, Rosemont, Illinois.

The incidence of primary cutaneous melanoma continues to increase each year. Melanoma accounts for the majority of skin cancer-related deaths, but treatment is usually curative following early detection of disease. In this American Academy of Dermatology clinical practice guideline, updated treatment recommendations are provided for patients with primary cutaneous melanoma (American Joint Committee on Cancer stages 0-IIC and pathologic stage III by virtue of a positive sentinel lymph node biopsy). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01909622183258
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http://dx.doi.org/10.1016/j.jaad.2018.08.055DOI Listing
January 2019
19 Reads

Sentinel node for malignant melanoma: An observational study of a consecutive single centre experience.

Eur J Surg Oncol 2019 02 19;45(2):225-230. Epub 2018 Oct 19.

Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy at the University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden.

Introduction: Sentinel node biopsy (SNB) for melanoma gives prognostic information, however the success is dependent on several factors. The aim of this study was to describe outcome data after the introduction of the technique at our centre, including analysis of false negative rate (FNR), predictive factors for positive sentinel node (SN) and non-sentinel node (NSN), as well as prognostic factors for melanoma-specific survival (MSS).

Materials And Methods: This is a retrospective observational study of a prospectively kept database at Sahlgrenska University Hospital. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07487983183141
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http://dx.doi.org/10.1016/j.ejso.2018.08.031DOI Listing
February 2019
27 Reads

Inter-observer variation in the histopathology reports of head and neck melanoma; a comparison between the seventh and eighth edition of the AJCC staging system.

Eur J Surg Oncol 2019 02 25;45(2):235-241. Epub 2018 Oct 25.

Department of Head and Neck Surgery and Oncology at the Netherlands Cancer Institute-Antoni van Leeuwenhoek, Plesmanlaan 121, NL-1066 CX Amsterdam, the Netherlands. Electronic address:

Background: TNM staging of melanoma has recently been altered by the introduction of the 8th edition of the AJCC Cancer Staging manual. The purpose of this study is to analyze the inter-observer variation of histopathology reports and its effect on recommended treatment policy.

Methods: We retrospectively analyzed 296 cases, diagnosed as primary cutaneous head and neck melanoma (2005-2016), referred to the Netherlands Cancer Institute (NCI) for treatment after prior diagnosis in another hospital (non-NCI). Read More

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http://dx.doi.org/10.1016/j.ejso.2018.10.529DOI Listing
February 2019
2 Reads

Sentinel Lymph Node Biopsy: Past and Present Implications for the Management of Cutaneous Melanoma with Nodal Metastasis.

Authors:
Abel Gonzalez

Am J Clin Dermatol 2018 Nov;19(Suppl 1):24-30

Mohs Surgery Unit, Institute of Oncology Angel H. Roffo, University of Buenos Aires, Av San Martin 5481, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina.

Although significant progress has been made in the understanding of melanoma pathophysiology and therapy, patients with metastatic melanoma still have a poor prognosis. The management of regional nodes remains a matter of debate. By replacing elective lymph node dissection, sentinel lymph node biopsy has revolutionized the treatment of malignant melanoma. Read More

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http://link.springer.com/10.1007/s40257-018-0379-0
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http://dx.doi.org/10.1007/s40257-018-0379-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244615PMC
November 2018
7 Reads