15 results match your criteria Senshin Iyaku Kenkyu Shinko Zaidan Annual Report of the Pharmacopsychiatry Research Foundation[Journal]

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Relationships between Internet addiction and clinicodemographic and behavioral factors.

Neuropsychiatr Dis Treat 2019 26;15:739-752. Epub 2019 Mar 26.

Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan,

Backgrounds And Aims: While the Internet became an indispensable component of our contemporary life, public and academic attention is also gathered to its negative impact, namely Internet addiction (IA). Although clinicodemographic and behavioral factors are hypothetically implicated in the mechanism of IA, it still remains largely unknown how such factors are linked to IA severity. Thus, this study sought to examine relationships among IA severity and factors potentially associated with IA in Japanese students in different educational stages. Read More

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http://dx.doi.org/10.2147/NDT.S193357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440534PMC

N-glycome inheritance from cells to extracellular vesicles in B16 melanomas.

FEBS Lett 2019 Apr 3. Epub 2019 Apr 3.

Department of Systems Biology in Thromboregulation, Kagoshima University Graduate School of Medical and Dental Sciences, Japan.

We investigated the correlation between metastatic behaviors of tumor cells and asparagine-linked glycosylation (N-glycosylation) of tumor-derived extracellular vesicles (EVs). Three mouse melanoma B16 variants with distinct metastatic potentials show similar gene expression levels and enzymatic activities of glycosyltransferases involved in N-glycosylation. All melanoma variants and EVs have nearly identical profiles of de-sialylated N-glycans. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/1873-3468.13
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http://dx.doi.org/10.1002/1873-3468.13377DOI Listing
April 2019
3 Reads

Plasma cell differentiation during the germinal center reaction.

Immunol Rev 2019 Mar;288(1):64-74

Laboratory of Lymphocyte Differentiation, WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan.

Germinal centers (GCs) are formed in secondary lymphoid tissues upon immunization with T-dependent antigens. In GCs, somatic hypermutation generates B cells with increased antibody affinity and these high-affinity B cells preferentially differentiate into plasma cells, which home to bone marrow and confer long-lived humoral immunity. Recent studies have shed new light on the cellular and molecular basis for initiating the transition from a GC B cell to a plasma cell. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/imr.12751
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http://dx.doi.org/10.1111/imr.12751DOI Listing
March 2019
2 Reads

Brain-derived and circulating vesicle profiles indicate neurovascular unit dysfunction in early Alzheimer's disease.

Brain Pathol 2019 Jan 10. Epub 2019 Jan 10.

School of Biological Sciences, Nanyang Technological University, Singapore, Singapore.

Vascular factors that reduce blood flow to the brain are involved in apparition and progression of dementia. We hypothesized that cerebral hypoperfusion (CH) might alter the molecular compositions of brain intercellular communication mechanisms while affecting the neurovascular unit in preclinical and clinical human dementias. To test that hypothesis, mice were subjected to bilateral common carotid stenosis (BCAS) and the molecular compositions of brain-derived and circulating extracellular vesicles (EVs) were assessed. Read More

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http://dx.doi.org/10.1111/bpa.12699DOI Listing
January 2019
15 Reads

Comparison of emotional processing assessed with fear conditioning by interpersonal conflicts in patients with depression and schizophrenia.

Psychiatry Clin Neurosci 2019 Mar 25;73(3):116-125. Epub 2018 Dec 25.

Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan.

Aim: While emotional processing is implicated in various psychiatric illnesses, its differences among diagnoses are unclear. We compared associative learning of social values in patients with depression and schizophrenia by measuring skin conductance response to interpersonal stimuli.

Methods: We included 20 female outpatients each with depression and schizophrenia. Read More

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http://doi.wiley.com/10.1111/pcn.12805
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http://dx.doi.org/10.1111/pcn.12805DOI Listing
March 2019
17 Reads

Survivin overexpression via adeno-associated virus vector Rh10 ameliorates ischemic damage after middle cerebral artery occlusion in rats.

Eur J Neurosci 2018 Dec 10;48(12):3466-3476. Epub 2018 Oct 10.

Division of Genetic Therapeutics, Center for Molecular Medicine, Jichi Medical University, Tochigi, Japan.

Survivin, a member of the inhibitors of apoptosis protein gene family, inhibits the activity of caspase, leading to a halt of the apoptotic process. Our study focused on the neuroprotective effect of survivin after transient middle cerebral artery occlusion (MCAO) with intraparenchymal administration of an adeno-associated virus (AAV) vector. His-tagged survivin was cloned and packaged into the AAV-rh10 vector. Read More

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http://dx.doi.org/10.1111/ejn.14169DOI Listing
December 2018
5 Reads

Normal peripheral circadian phase in the old-old with abnormal circadian behavior.

Genes Cells 2018 Oct 5;23(10):849-859. Epub 2018 Sep 5.

The Research Institute for Time Studies, Yamaguchi University, Yamaguchi, Japan.

Almost all organisms maintain a circadian clock from birth to death to synchronize their own physiology and behavior with the earth's rotation. However, extensive studies based on animal experiments have showed that aging results in circadian dysfunction. Human studies have also indicated age-associated abnormal phase, reduced amplitude and enhanced fragmentation in circadian physiology and behavior, thereby strongly implying age-related dysfunction of the clock machinery. Read More

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http://dx.doi.org/10.1111/gtc.12633DOI Listing
October 2018
2 Reads

Relationship between bite size per mouthful and dental arch size in healthy subjects.

J Physiol Sci 2019 Jan 28;69(1):159-163. Epub 2018 Jul 28.

Department of Physiology, Tsurumi University School of Dental Medicine, 2-1-3 Tsurumi, Tsurumi-ku, Yokohama, 230-8501, Japan.

Although multiple factors influence food bite size, the relationship between food bite size per mouthful and mandible or tongue size remains poorly understood. Here, we examined the correlations between food bite size and the lower dental arch size (an indicator of tongue size) in human subjects with good oral and general health, using fish sausage and bread as test foods. Notably, bite size of both foods was significantly positively correlated with the lower dental arch size, whereas masticatory performance (measured in terms of glucose extraction from a gummy jelly) showed no dependence on bite size. Read More

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http://dx.doi.org/10.1007/s12576-018-0630-8DOI Listing
January 2019
15 Reads

Development and validation of the 25-item Hikikomori Questionnaire (HQ-25).

Psychiatry Clin Neurosci 2018 Oct 27;72(10):780-788. Epub 2018 Jul 27.

Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Aim: Hikikomori, a form of severe social withdrawal, is an emerging issue in mental health, for which validated measurement tools are lacking. The object was to develop a self-report scale of hikikomori, and assess its psychometric properties and diagnostic accuracy.

Methods: A sample of 399 participants from clinical and community settings completed measures. Read More

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http://doi.wiley.com/10.1111/pcn.12691
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http://dx.doi.org/10.1111/pcn.12691DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221010PMC
October 2018
15 Reads

Surface morphology of the orbitofrontal cortex in individuals at risk of psychosis: a multicenter study.

Eur Arch Psychiatry Clin Neurosci 2018 Mar 23. Epub 2018 Mar 23.

Department of Neuropsychiatry, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences, 2630 Sugitani, Toyama, Japan.

Changes in the surface morphology of the orbitofrontal cortex (OFC), such as a fewer orbital sulci and altered sulcogyral pattern of the 'H-shaped' orbital sulcus, have been reported in schizophrenia, possibly reflecting abnormal neurodevelopment during gestation. However, whether high-risk subjects for developing psychosis also exhibit these gross morphologic anomalies is not well documented. This multicenter MRI study from four scanning sites in Japan investigated the distribution of the number of intermediate and posterior orbital sulci, as well as the OFC sulcogyral pattern, in 125 individuals with an at-risk mental state (ARMS) [of whom 22 later developed psychosis (ARMS-P) and 89 did not (ARMS-NP)] and 110 healthy controls. Read More

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http://dx.doi.org/10.1007/s00406-018-0890-6DOI Listing
March 2018
3 Reads

Response to: ' is not associated with the development of methotrexate pneumonitis in the UK population: results from a genome wide association study' by Bluett .

Ann Rheum Dis 2017 Dec 12;76(12):e52. Epub 2017 May 12.

Clinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital, National Hospital Organization, Sagamihara, Japan.

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http://dx.doi.org/10.1136/annrheumdis-2017-211518DOI Listing
December 2017
26 Reads

High Prevalence of Obesity, Hypertension, Hyperlipidemia, and Diabetes Mellitus in Japanese Outpatients with Schizophrenia: A Nationwide Survey.

PLoS One 2016 17;11(11):e0166429. Epub 2016 Nov 17.

Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.

Background: Patients with schizophrenia have significantly shorter life expectancy than the general population, and a problem they commonly face is an unhealthy lifestyle, which can lead to obesity and metabolic syndrome. There is a very clear need to determine the prevalence of obesity, hypertension, hyperlipidemia, and diabetes mellitus which are components of metabolic syndrome in patients with schizophrenia, but there has been a paucity of large-scale studies examining this situation in Japan. The aim of our study was to address this need. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0166429PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5113959PMC
June 2017
7 Reads

Effects of Toll-Like Receptor 4 Antagonists Against Cerebral Vasospasm After Experimental Subarachnoid Hemorrhage in Mice.

Mol Neurobiol 2017 Oct 13;54(8):6624-6633. Epub 2016 Oct 13.

Department of Neurosurgery, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie, 514-8507, Japan.

Toll-like receptor 4 (TLR4) signaling may play a crucial role in the occurrence of cerebral vasospasm after subarachnoid hemorrhage (SAH). The main purpose of this study was to assess if selective blockage of TLR4 on cerebral arteries prevents cerebral vasospasm development and neurological impairments after SAH in mice. One hundred fourteen mice underwent endovascular perforation SAH or sham operation and were randomly divided into the following 6 groups: sham+vehicle, sham+LPS-RS ultrapure 8 μg, sham+LPS-RS ultrapure 40 μg, SAH+vehicle, SAH+LPS-RS ultrapure 8 μg, and SAH+LPS-RS ultrapure 40 μg. Read More

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http://dx.doi.org/10.1007/s12035-016-0178-7DOI Listing
October 2017
7 Reads

Innovative Methods For Early Diagnostic Of Cancer.

Value Health 2015 Nov 20;18(7):A347. Epub 2015 Oct 20.

LLP "Radian", Almaty, Kazakhstan.

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http://dx.doi.org/10.1016/j.jval.2015.09.619DOI Listing
November 2015
1 Read

Japan's advanced medicine.

Biosci Trends 2013 Oct;7(5):245-9

Department of Public Health, Yamagata University Graduate School of Medical Science, Yamagata, Japan.

Like health care systems in other developed countries, Japan's health care system faces significant challenges due to aging of the population and economic stagnation. Advanced medicine (Senshin Iryou) is a unique system of medical care in Japan offering highly technology-driven medical care that is not covered by public health insurance. Advanced medicine has recently developed and expanded as part of health care reform. Read More

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October 2013
8 Reads
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