10 results match your criteria Senshin Iyaku Kenkyu Shinko Zaidan Annual Report of the Pharmacopsychiatry Research Foundation[Journal]

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Survivin overexpression via adeno-associated virus vector Rh10 ameliorates ischemic damage after middle cerebral artery occlusion in rats.

Eur J Neurosci 2018 Dec 10;48(12):3466-3476. Epub 2018 Oct 10.

Division of Genetic Therapeutics, Center for Molecular Medicine, Jichi Medical University, Tochigi, Japan.

Survivin, a member of the inhibitors of apoptosis protein gene family, inhibits the activity of caspase, leading to a halt of the apoptotic process. Our study focused on the neuroprotective effect of survivin after transient middle cerebral artery occlusion (MCAO) with intraparenchymal administration of an adeno-associated virus (AAV) vector. His-tagged survivin was cloned and packaged into the AAV-rh10 vector. Read More

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December 2018
3 Reads

Normal peripheral circadian phase in the old-old with abnormal circadian behavior.

Genes Cells 2018 Oct 5;23(10):849-859. Epub 2018 Sep 5.

The Research Institute for Time Studies, Yamaguchi University, Yamaguchi, Japan.

Almost all organisms maintain a circadian clock from birth to death to synchronize their own physiology and behavior with the earth's rotation. However, extensive studies based on animal experiments have showed that aging results in circadian dysfunction. Human studies have also indicated age-associated abnormal phase, reduced amplitude and enhanced fragmentation in circadian physiology and behavior, thereby strongly implying age-related dysfunction of the clock machinery. Read More

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October 2018
1 Read

Relationship between bite size per mouthful and dental arch size in healthy subjects.

J Physiol Sci 2018 Jul 28. Epub 2018 Jul 28.

Department of Physiology, Tsurumi University School of Dental Medicine, 2-1-3 Tsurumi, Tsurumi-ku, Yokohama, 230-8501, Japan.

Although multiple factors influence food bite size, the relationship between food bite size per mouthful and mandible or tongue size remains poorly understood. Here, we examined the correlations between food bite size and the lower dental arch size (an indicator of tongue size) in human subjects with good oral and general health, using fish sausage and bread as test foods. Notably, bite size of both foods was significantly positively correlated with the lower dental arch size, whereas masticatory performance (measured in terms of glucose extraction from a gummy jelly) showed no dependence on bite size. Read More

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July 2018
12 Reads

Development and validation of the 25-item Hikikomori Questionnaire (HQ-25).

Psychiatry Clin Neurosci 2018 Oct 27;72(10):780-788. Epub 2018 Jul 27.

Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Aim: Hikikomori, a form of severe social withdrawal, is an emerging issue in mental health, for which validated measurement tools are lacking. The object was to develop a self-report scale of hikikomori, and assess its psychometric properties and diagnostic accuracy.

Methods: A sample of 399 participants from clinical and community settings completed measures. Read More

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October 2018
6 Reads

Surface morphology of the orbitofrontal cortex in individuals at risk of psychosis: a multicenter study.

Eur Arch Psychiatry Clin Neurosci 2018 Mar 23. Epub 2018 Mar 23.

Department of Neuropsychiatry, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences, 2630 Sugitani, Toyama, Japan.

Changes in the surface morphology of the orbitofrontal cortex (OFC), such as a fewer orbital sulci and altered sulcogyral pattern of the 'H-shaped' orbital sulcus, have been reported in schizophrenia, possibly reflecting abnormal neurodevelopment during gestation. However, whether high-risk subjects for developing psychosis also exhibit these gross morphologic anomalies is not well documented. This multicenter MRI study from four scanning sites in Japan investigated the distribution of the number of intermediate and posterior orbital sulci, as well as the OFC sulcogyral pattern, in 125 individuals with an at-risk mental state (ARMS) [of whom 22 later developed psychosis (ARMS-P) and 89 did not (ARMS-NP)] and 110 healthy controls. Read More

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March 2018
1 Read

Response to: ' is not associated with the development of methotrexate pneumonitis in the UK population: results from a genome wide association study' by Bluett .

Ann Rheum Dis 2017 Dec 12;76(12):e52. Epub 2017 May 12.

Clinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital, National Hospital Organization, Sagamihara, Japan.

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December 2017
22 Reads

High Prevalence of Obesity, Hypertension, Hyperlipidemia, and Diabetes Mellitus in Japanese Outpatients with Schizophrenia: A Nationwide Survey.

PLoS One 2016 17;11(11):e0166429. Epub 2016 Nov 17.

Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.

Background: Patients with schizophrenia have significantly shorter life expectancy than the general population, and a problem they commonly face is an unhealthy lifestyle, which can lead to obesity and metabolic syndrome. There is a very clear need to determine the prevalence of obesity, hypertension, hyperlipidemia, and diabetes mellitus which are components of metabolic syndrome in patients with schizophrenia, but there has been a paucity of large-scale studies examining this situation in Japan. The aim of our study was to address this need. Read More

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June 2017
6 Reads

Effects of Toll-Like Receptor 4 Antagonists Against Cerebral Vasospasm After Experimental Subarachnoid Hemorrhage in Mice.

Mol Neurobiol 2017 Oct 13;54(8):6624-6633. Epub 2016 Oct 13.

Department of Neurosurgery, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie, 514-8507, Japan.

Toll-like receptor 4 (TLR4) signaling may play a crucial role in the occurrence of cerebral vasospasm after subarachnoid hemorrhage (SAH). The main purpose of this study was to assess if selective blockage of TLR4 on cerebral arteries prevents cerebral vasospasm development and neurological impairments after SAH in mice. One hundred fourteen mice underwent endovascular perforation SAH or sham operation and were randomly divided into the following 6 groups: sham+vehicle, sham+LPS-RS ultrapure 8 μg, sham+LPS-RS ultrapure 40 μg, SAH+vehicle, SAH+LPS-RS ultrapure 8 μg, and SAH+LPS-RS ultrapure 40 μg. Read More

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October 2017
4 Reads

Innovative Methods For Early Diagnostic Of Cancer.

Value Health 2015 Nov 20;18(7):A347. Epub 2015 Oct 20.

LLP "Radian", Almaty, Kazakhstan.

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November 2015

Japan's advanced medicine.

Biosci Trends 2013 Oct;7(5):245-9

Department of Public Health, Yamagata University Graduate School of Medical Science, Yamagata, Japan.

Like health care systems in other developed countries, Japan's health care system faces significant challenges due to aging of the population and economic stagnation. Advanced medicine (Senshin Iryou) is a unique system of medical care in Japan offering highly technology-driven medical care that is not covered by public health insurance. Advanced medicine has recently developed and expanded as part of health care reform. Read More

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October 2013
4 Reads
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