5,976 results match your criteria Seminoma


[Organ-sparing partial orchietectomy for testicular adenomatoid tumor].

Beijing Da Xue Xue Bao Yi Xue Ban 2019 Apr;51(2):365-368

Department of Urology, Peking University Third Hospital, Beijing 100191, China.

Objective: The incidence of testicular tumors is relatively low which are mainly malignant, so the main way to treat testicular tumors is radical testicular resection. Testicular adenomatoid tumor is a rare testicular benign tumor, but is easily misdiagnosed as malignant tumors with removal of organs. This article aims to explore the clinical features of testicular adenomatoid tumor and its treatment. Read More

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FDG PET/CT of Spinal Brucellosis.

Clin Nucl Med 2019 Apr 12. Epub 2019 Apr 12.

A 17-year-old adolescent boy's known case of classical seminoma stage IB for which he underwent right radical orchiectomy. At the first-year follow-up, CT abdomen and pelvis was performed and showed lytic vertebral lesion with left paravertebral necrotic mass that warranted further investigation to exclude disease recurrence. FDG PET/CT scan was performed to evaluate the extent of disease and showed high uptake in the same areas. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002566DOI Listing
April 2019
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Clinicopathologic Characterization of Bilateral Testicular Germ Cell Tumors With Immunohistochemical Evaluation of Mismatch Repair and BRAF (V600E) Genes Mutations.

Int J Surg Pathol 2019 Apr 15:1066896919842939. Epub 2019 Apr 15.

1 Indiana University, Indianapolis, IN, USA.

The incidence of bilateral testicular germ cell tumor (TGCT) is 1% to 5%. Despite the high rate of treatment success, resistance to chemotherapy has a detrimental effect. Some studies found MMR and BRAF gene mutations to be associated with chemotherapy resistance, which has not been found by others. Read More

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http://dx.doi.org/10.1177/1066896919842939DOI Listing

Erratum: Spermatocytic seminoma with rhabdomyoblastic differentiation: Case report and review of literature.

Authors:

Indian J Pathol Microbiol 2019 Apr-Jun;62(2):363

[This corrects the article DOI: 10.4103/IJPM.IJPM_243_17]. Read More

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http://dx.doi.org/10.4103/0377-4929.255848DOI Listing
April 2019
1 Read

Immunolocalization of DMRTB1 in human testis with normal and impaired spermatogenesis.

Andrology 2019 Mar 28. Epub 2019 Mar 28.

Institute for Anatomy, University of Veterinary Medicine Hannover, Hannover, Germany.

Background: The transcription factor DMRTB1 plays a pivotal role in coordinating the transition between mitosis and meiosis in murine germ cells. No reliable data are available for human testis.

Objectives: The present study aims to examine the testicular expression pattern of DMRTB1 in men showing normal and impaired spermatogenesis. Read More

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http://dx.doi.org/10.1111/andr.12617DOI Listing
March 2019
1 Read

Intratubular Teratoma: A Rare Form of Testicular Germ Cell Neoplasia.

Int J Surg Pathol 2019 Mar 24:1066896919836491. Epub 2019 Mar 24.

1 Northwell Health Lenox Hill Hospital, New York, NY, USA.

Germ cell neoplasia in situ is the initial manifestation for invasive germ cell tumor. Further progression will result in intratubular germ cell tumor with the majority being intratubular seminoma or intratubular embryonal carcinoma. Intratubular teratoma in the testis is exceptionally rare with no well-documented cases to our knowledge. Read More

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http://dx.doi.org/10.1177/1066896919836491DOI Listing
March 2019
1 Read
0.961 Impact Factor

[Testicular germ cell tumors: Histopathological and molecular features].

Bull Cancer 2019 Apr 21;106(4):328-341. Epub 2019 Mar 21.

Hôpital Foch, service d'anatomie et cytologie pathologiques, 40, rue Worth, 92150 Suresnes, France; Institut Curie, service de pathologie, 35, rue Dailly, 92240 Saint Cloud, France. Electronic address:

In 2016, the WHO classification of testicular germ cell tumors was revised considering advances in the understanding of their tumorigenesis and molecular features. This restructuring led to a division into two major groups with, on one hand, prepubertal-type tumors, not derived from germ cell neoplasia in situ (GCNIS), and on the other hand, postpubertal-type tumors, GCNIS-derived, which occur in youg men (seminoma and non seminomatous germ cell tumors - embryonal carcinoma, yolk sac tumor, teratoma and choriocarcinoma essentially). The term germ cell neoplasia in situ is consensually accepted as a new terminology for the precursor lesion. Read More

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http://dx.doi.org/10.1016/j.bulcan.2019.02.004DOI Listing
April 2019
1 Read

Adjuvant radiotherapy for Stage I seminoma: A Single-institutional experience.

J Cancer Res Ther 2019 Mar;15(Supplement):S87-S90

Department of Radiation Oncology, Kocaeli University Faculty of Medicine, Kocaeli, Turkey.

Objectives: There is no consensus regarding the management of Stage 1 seminomas following inguinal orchiectomy. In this study, we evaluated the treatment results and treatment-related toxicity for patients with Stage 1 seminomas treated with adjuvant radiotherapy (RT) at a single institution.

Methods: Sixty-five patients who underwent adjuvant RT following orchiectomy for Stage 1 seminomas between January 1996 and December 2007 were retrospectively reviewed. Read More

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http://dx.doi.org/10.4103/jcrt.JCRT_916_16DOI Listing
March 2019
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Poor prognosis of retroperitoneal mixed extragonadal germ cell tumors in an HIV-infected man with severe immunosuppression and bilateral cryptorchidism: a case report.

Authors:
Ruili Li Hongjun Li

BMC Cancer 2019 Mar 18;19(1):244. Epub 2019 Mar 18.

Department of Radiology, Beijing Youan Hospital, Capital Medical University, No. 8, Xi Tou Tiao, Youanmen Wai, Fengtai District, Beijing, 100069, China.

Background: Nonseminomatous germ cell tumors (NSGCTs) represent one of the main groups of germ cell tumors (GCTs), and they have a more invasive course than seminomatous GCTs. Human immunodeficiency virus (HIV) positivity is considered to be a risk factor for testicular seminoma patients, but reports about HIV-infected individuals with NSGCTs are rare.

Case Presentation: We report a case of a retroperitoneal mixed extragonadal germ cell tumor in an HIV-infected man who has been diagnosed with bilateral cryptorchidism since birth. Read More

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http://dx.doi.org/10.1186/s12885-019-5456-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423750PMC
March 2019
1 Read

Reclassification of good-risk seminoma: prognostic factors, novel biomarkers and implications for clinical management.

Future Oncol 2019 Mar 18. Epub 2019 Mar 18.

Department of Medical Oncology, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy.

Germ cell tumors represent 11% of the cancers diagnosed in adolescent males and are the most common solid tumors in adult men between the ages of 20 and 35. Pure seminoma accounts for around 50% of all testicular germ cell tumors. The prognostic classification of the International Germ Cell Cancer Collaborative Group for good-prognosis seminoma includes both nodal disease and pulmonary visceral metastases. Read More

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http://dx.doi.org/10.2217/fon-2018-0850DOI Listing
March 2019
1 Read

Cell-to-cell variation of chromosomal number in the adult testicular germ cell tumors: a comparison of chromosomal instability among histological components and its putative role in tumor progression.

Virchows Arch 2019 Mar 14. Epub 2019 Mar 14.

Department of Basic Pathology, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, 359-8513, Japan.

By allelotyping analysis, we previously reported a putative progression pathway from germ cell neoplasia in situ (GCNIS) to seminoma, then to embryonal carcinoma in mixed-type testicular germ cell tumors (TGCTs), and detected that loss of heterozygosity events in seminoma components in mixed tumors were more frequent than those in pure seminomas. To elucidate a role of chromosomal instability in the progression of non-seminomatous germ cell tumor (NSGCT), we performed fluorescence in situ hybridization with centromeric probes for chromosomes 1, 7, 8, 12, 17, and X on a cohort of 52 TGCT cases with 103 histologically distinct components: 39 GCNIS lesions (16 and 23 in tumors with and without NSGCT components, respectively), 39 seminomas (27 as pure seminomas and 12 in mixed tumors), and 25 embryonal carcinomas. On a total component basis, both the mean copy number per tumor cell nucleus and the deviations from the modal number of all chromosomes examined significantly increased from GCNIS to seminoma, then to embryonal carcinoma with few exceptions. Read More

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http://dx.doi.org/10.1007/s00428-019-02560-6DOI Listing
March 2019
2 Reads

Serum Levels of MicroRNA-371a-3p (M371 Test) as a New Biomarker of Testicular Germ Cell Tumors: Results of a Prospective Multicentric Study.

J Clin Oncol 2019 Mar 15:JCO1801480. Epub 2019 Mar 15.

3 University of Bremen, Bremen, Germany.

Purpose: Previous studies suggested that serum levels of microRNA (miR)-371a-3p (so-called M371 test) have a much higher sensitivity and specificity than the classic markers of testicular germ cell tumors (GCTs) and are applicable toward both seminoma and nonseminoma. We sought to confirm the usefulness of this test as a novel biomarker for GCT.

Patients And Methods: In a prospective, multicentric study, serum samples of 616 patients with testicular GCTs and 258 male controls were examined for serum levels of miRNA-371a-3p (miR levels) by quantitative polymerase chain reaction. Read More

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http://dx.doi.org/10.1200/JCO.18.01480DOI Listing
March 2019
3 Reads

mA RNA modification and its writer/reader VIRMA/YTHDF3 in testicular germ cell tumors: a role in seminoma phenotype maintenance.

J Transl Med 2019 Mar 12;17(1):79. Epub 2019 Mar 12.

Cancer Biology and Epigenetics Group (CBEG), IPO Porto Research Center (CI-IPOP), Portuguese Oncology Institute of Porto (IPO Porto) & Porto Comprehensive Cancer Center (P.CCC), R. Dr. António Bernardino de Almeida, 4200-072, Porto, Portugal.

Background: Covalent RNA modifications, such as N-6-methyladenosine (mA), have been associated with various biological processes, but their role in cancer remains largely unexplored. mA dynamics depends on specific enzymes whose deregulation may also impact in tumorigenesis. Herein, we assessed the differential abundance of mA, its writer VIRMA and its reader YTHDF3, in testicular germ cell tumors (TGCTs), looking for clinicopathological correlates. Read More

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http://dx.doi.org/10.1186/s12967-019-1837-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416960PMC
March 2019
1 Read

Mixed germ cell tumor composed of a tridermic testicular teratoma and seminoma in a rooster.

J Vet Diagn Invest 2019 Mar 12:1040638719838001. Epub 2019 Mar 12.

Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA (Tavella, LeRoith).

A 5-y-old backyard Araucana-Americana rooster was presented to the regional diagnostic laboratory with a history of progressive lethargy and respiratory signs. Autopsy revealed a single large mass of testicular origin in the coelomic cavity, causing compression of other organs. Histologically, the mass was 1 neoplasm with mixed components of 2 different germ cell tumors, namely a teratoma composed of elements of all 3 primordial germ cell lines (ectoderm, mesoderm, and endoderm), and a seminoma consisting of round or polygonal cells arranged in sheets supported by a scant fibrovascular stroma. Read More

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http://dx.doi.org/10.1177/1040638719838001DOI Listing
March 2019
2 Reads

Granulomatous CNS inflammation associated with seminoma.

J Neurol 2019 Mar 11. Epub 2019 Mar 11.

Centre for Neurosarcoidosis, Neuroimmunology Unit, Institute of Immunity and Transplantation, University College London, London, NW3 2PF, UK.

Two cases in which a neurological disorder was identified pathologically to be due to a granulomatous infiltration were found after diagnosis to have an associated testicular seminoma with pathologically proven lymphatic metastasis. We present the clinical and imaging features, and pathological appearances of the lymphatic tissue and the brain. We summarise the literature to date and discuss the pathogenesis of the disorder and its treatment. Read More

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http://dx.doi.org/10.1007/s00415-019-09270-8DOI Listing
March 2019
1 Read

Current pharmacotherapy for testicular germ cell cancer.

Expert Opin Pharmacother 2019 May 8;20(7):837-850. Epub 2019 Mar 8.

a Department of Oncology, Hematology and Bone Marrow Transplantation with Division of Pneumology , University Medical Center Eppendorf , Hamburg , Germany.

Introduction: With the implementation of platinum-based chemotherapy, germ cell tumors (GCTs) became a model for a curable solid tumor, with survival rates of 95% in all patients with >80% survival in metastatic stages. Areas covered: Herein, the authors review the current standards of adjuvant chemotherapy for stage I GCTs as well as first-line and salvage treatments for metastatic disease. Novel approaches for refractory disease are also reviewed. Read More

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http://dx.doi.org/10.1080/14656566.2019.1583745DOI Listing
May 2019
2 Reads

Recent advances in the regulation of testicular germ cell tumors by microRNAs.

Front Biosci (Landmark Ed) 2019 03 1;24:765-776. Epub 2019 Mar 1.

State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.

Testicular germ cell tumors (TGCTs) are generally rare but represent the most common solid tumors in young men. They are classified broadly into seminoma, which resemble primordial germ cells (PGCs), and non-seminoma, which are either undifferentiated (embryonic carcinoma) or differentiated (teratoma, yolk sac tumor, choriocarcinomas) patterning. A widespread role for microRNAs (miRNAs), in diverse molecular processes driving initiation and progression of various types of TGCTs has been recently studied. Read More

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March 2019
8 Reads

Clinical and radiographic characterization of primary seminomas and nonseminomatous germ cell tumors.

Niger J Clin Pract 2019 Mar;22(3):342-349

Department of Medical Oncology, Jiangsu Cancer Hospital and Jiangsu Institute of Cancer Research and The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, Jiangsu, P. R. China.

Background: Primary malignant mediastinal germ cell tumors (PMMGCTs) including seminomas and nonseminomatous germ cell tumors (NSGCTs) are rare, and sometimes the diagnosis is very difficult.

Purpose: The purpose of this study is to compare the clinical characteristics, biomarkers, and imaging findings of seminomas and NSGCTs and to determine whether these features could help distinguish these two types of PMMGCT.

Material And Methods: A retrospective study of 24 male patients with histopathologically proven PMMGCT was performed. Read More

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http://dx.doi.org/10.4103/njcp.njcp_448_18DOI Listing
March 2019
4 Reads

Distinct Metabolic Features of Seminoma and Embryonal Carcinoma Revealed by Combined Transcriptome and Metabolome Analyses.

J Proteome Res 2019 Apr 12;18(4):1819-1826. Epub 2019 Mar 12.

State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology , Chinese Academy of Sciences , Beijing 100101 , China.

Seminoma and embryonal carcinoma (EC), two typical types of testicular germ cell tumors (TGCTs), present significant differences in growth behavior, expression characteristics, differentiation potential, clinical features, therapy, and prognosis. The purpose of this study was to compare the distinctive or preference metabolic pathways between seminoma and EC. The Cancer Genome Atlas revealed that many genes encoding metabolic enzymes could distinguish between seminoma and EC. Read More

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http://dx.doi.org/10.1021/acs.jproteome.9b00007DOI Listing
April 2019
4 Reads

Primary Seminoma Localized in Mediastinum: Case Report.

Open Access Maced J Med Sci 2019 Feb 25;7(3):384-387. Epub 2019 Jan 25.

Acibadem Sistina Hospital, Skopje, Republic of Macedonia.

Background: Primary mediastinal seminomas most commonly occur in young men, and they are localised in the anterior mediastinum.

Case Presentation: The presented study is a case report of a 34-year-old man suffering from a mediastinal tumour in size of 19 cm, with pleural and pericardial effusion. The patient complains of cough, difficulty breathing, weight loss, and pronounced tiredness. Read More

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http://dx.doi.org/10.3889/oamjms.2019.122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390165PMC
February 2019
2 Reads

[Metachronous Development of Mantle Cell Lymphoma during Active Surveillance in a Patient with Stage I Testicular Cancer].

Hinyokika Kiyo 2018 Dec;64(12):509-513

The Department of Urology, Faculty of Medicine, University of Tsukuba.

A 78-year-old man presented with swelling of para-aortic and left iliac lymph nodes (LNs). He had undergone left high orchiectomy 10 years ago. He was diagnosed with stage I seminoma, and was managed with active surveillance. Read More

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http://dx.doi.org/10.14989/ActaUrolJap_64_12_509DOI Listing
December 2018
1 Read

Positron Emission Tomography-Positive Post-Chemotherapy Seminoma Masses: Time to Reevaluate the Role of Radiotherapy?

J Clin Oncol 2019 Apr 27;37(11):937-938. Epub 2019 Feb 27.

Vedang Murthy, MD, and Carlton Johnny, MBBS, Tata Memorial Centre, Mumbai, India; and Robert Huddart, PhD, Institute of Cancer Research and Royal Marsden Hospital NHS, London, United Kingdom.

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http://dx.doi.org/10.1200/JCO.18.01991DOI Listing
April 2019
1 Read

A rare testicular tumor: primary carcinoid tumor.

Tumori 2019 Feb 24:300891619832263. Epub 2019 Feb 24.

1 Department of Pathology, University Teaching Hospital of Lomé, Togo.

Background:: Primary carcinoid tumors are rare and constitute 0.23% of all testicular tumors. We report a case of primary carcinoid tumor of testicular localization, with a review of the literature. Read More

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http://dx.doi.org/10.1177/0300891619832263DOI Listing
February 2019
2 Reads

Management of residual masses in testicular germ cell tumors.

Expert Rev Anticancer Ther 2019 Apr 22;19(4):291-300. Epub 2019 Feb 22.

a Department of Urology, Urologic Oncology, Robot-assisted and Specialized Urologic Surgery , University Hospital Cologne , Köln , Germany.

Introduction: About 50% of all patients with advanced testicular cancer demonstrate residual retroperitoneal or extraretroperitoneal masses. About two thirds of the masses harbour necrosis/fibrosis only whereas as about 10% and 40% harbour vital cancer or teratoma. Appropriate therapy will result in a high cure rate if performed properly. Read More

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http://dx.doi.org/10.1080/14737140.2019.1580146DOI Listing
April 2019
4 Reads

Spontaneous testicular tumor regression: case report and historical review.

Ecancermedicalscience 2018 18;12:888. Epub 2018 Dec 18.

Oncological Medicine Service, Regional Hospital of Lambayeque, Chiclayo 882, Peru.

Spontaneous regression of a primary testicular germ-cell tumour (GCT), over time known as 'Burned out', 'Shrinking Seminoma', 'pT0', 'Burnout' or 'Spontaneous Regression', is an uncommon, generally metastatic phenomenon, which may present elevated tumour markers and a suspicious testicular ultrasound image. The histological study of the testicle demonstrated morphological changes of complete or partial tumour regression and found fibrous scarring and other characteristic changes of this phenomenon, which in some cases include vestiges of GCT. There are few publications on testicular GCT tumour regression and those that exist present limited data on the biology of the disease and its etiopathogenesis. Read More

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http://dx.doi.org/10.3332/ecancer.2018.888DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351062PMC
December 2018
1 Read

Bifocal germinoma in a patient with 16p11.2 microdeletion syndrome.

Endocrinol Diabetes Metab Case Rep 2019 Feb 7;2019. Epub 2019 Feb 7.

Department of Endocrinology, Diabetes and Metabolism.

Intracranial germinomas are rare tumors affecting mostly patients at young age. Therefore, molecular data on its etiopathogenesis are scarce. We present a clinical case of a male patient of 25 years with an intracranial germinoma and a 16p11. Read More

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http://dx.doi.org/10.1530/EDM-18-0149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373620PMC
February 2019
17 Reads

Factors that impact the outcomes in testicular germ cell tumors in low-middle-income countries.

Med Oncol 2019 Feb 6;36(3):28. Epub 2019 Feb 6.

Department of Medical Oncology, Cancer Institute (WIA), Adyar, Chennai, Tamil Nadu, 600020, India.

Germ cell tumors (GCTs) are one of the most common tumors in adolescents and young adults. There is paucity of data on GCT from low-middle-income countries (LMIC). The present study was conducted to assess the demographic features, clinical manifestations, pathology, and outcomes of GCT patients treated at our center. Read More

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http://dx.doi.org/10.1007/s12032-019-1252-6DOI Listing
February 2019
2 Reads
2.058 Impact Factor

Preservation of Ejaculatory Function After Postchemotherapy Retroperitoneal Lymph Node Dissection (PC-RPLND) in Patients With Testicular Cancer: Template vs. Bilateral Resection.

Front Surg 2018 17;5:80. Epub 2019 Jan 17.

Department of Urology, Medical Faculty, University of Duesseldorf, Duesseldorf, Germany.

Post-chemotherapy retroperitoneal lymph node dissection (PC-RPLND) plays a crucial role in treatment of metastatic non-seminomatous germ cell cancer. To evaluate the functional outcome regarding the preservation of ejaculatory function comparing a bilateral vs. unilateral template resection in PC-RPLND patients. Read More

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http://dx.doi.org/10.3389/fsurg.2018.00080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345078PMC
January 2019
5 Reads

Testicular germ cell tumor: a comprehensive review.

Cell Mol Life Sci 2019 May 22;76(9):1713-1727. Epub 2019 Jan 22.

State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, 1 Beichen West Road, Chaoyang District, Beijing, 100101, China.

Testicular tumors are the most common tumors in adolescent and young men and germ cell tumors (TGCTs) account for most of all testicular cancers. Increasing incidence of TGCTs among males provides strong motivation to understand its biological and genetic basis. Gains of chromosome arm 12p and aneuploidy are nearly universal in TGCTs, but TGCTs have low point mutation rate. Read More

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http://dx.doi.org/10.1007/s00018-019-03022-7DOI Listing
May 2019
9 Reads

Management of Residual Mass in Germ Cell Tumors After Chemotherapy.

Curr Oncol Rep 2019 Jan 21;21(1). Epub 2019 Jan 21.

Department of Urology, Indiana University School of Medicine, 535 Barnhill Dr., Indianapolis, IN, 46202, USA.

Purpose Of Review: The purpose of this review is to educate medical oncologists on the management of patients with residual germ cell tumors and the role of surgical resection after platinum-based chemotherapy.

Recent Findings: Patients with non-seminomatous testicular cancer and residual enlarged retroperitoneal lymph nodes > 1 cm following induction chemotherapy with normal tumor markers should undergo a post-chemotherapy retroperitoneal lymph node dissection. All patients with primary mediastinal non-seminoma should undergo surgical resection of the mediastinal mass post-chemotherapy. Read More

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http://dx.doi.org/10.1007/s11912-019-0758-6DOI Listing
January 2019
3 Reads

[A CASE WITH LATE RECURRENCE OF EXTRAGONADAL GERM CELL TUMOR].

Nihon Hinyokika Gakkai Zasshi 2018 ;109(1):40-44

Department of Urology, Nagoya University Graduate School of Medicine.

A 61-year-old man had undergone resection of teratoma with a histological component of seminoma occurring in the anterior mediastinum at 26 years of age in 1978, followed by radiation treatment to the resected area. He had a recurrence tumor in the left retroperitoneum 2 years later, which was resected combined with left nephrectomy and was proved to be the same pathology as the initial tumor. At 36 years after the initial treatment, the tumor recurred in the right lung. Read More

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http://dx.doi.org/10.5980/jpnjurol.109.40DOI Listing
February 2019
2 Reads

True hermaphroditism with seminoma: A case report.

Mol Clin Oncol 2019 Jan 8;10(1):97-100. Epub 2018 Nov 8.

Department of Urology, Peking University Shenzhen Hospital, Institute of Urology, Shenzhen PKU-HKUST Medical Center, Shenzhen, Guangdong 518036, P.R. China.

The aim of the present study was to discuss the diagnosis and treatment of a patient with true hermaphroditism complicated by seminoma. The patient was a 35-year-old man who was admitted to the Peking University Shenzhen Hospital with a retractable mass in the left inguinal region for 20 years. A computed tomography examination revealed right cryptorchidism. Read More

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http://dx.doi.org/10.3892/mco.2018.1760DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313949PMC
January 2019
3 Reads

Testicular Seminoma in a Transgender Woman: A Case Report.

LGBT Health 2019 01;6(1):40-42

3 Department of Obstetrics and Gynecology, Denver Health, Denver, Colorado.

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http://dx.doi.org/10.1089/lgbt.2018.0173DOI Listing
January 2019
2 Reads

c-Src Recruitment is Involved in c-MET-Mediated Malignant Behaviour of NT2D1 Non-Seminoma Cells.

Int J Mol Sci 2019 Jan 14;20(2). Epub 2019 Jan 14.

Department of Anatomy, Histology, Forensic-Medicine and Orthopedics, "Sapienza" University of Rome, 00161 Rome, Italy.

c-MET pathway over-activation is the signature of malignancy acquisition or chemotherapy resistance of many cancers. We recently demonstrated that type II Testicular Germ Cell Tumours (TGCTs) express c-MET receptor. In particular, we elucidated that the non-seminoma lesions express c-MET protein at higher level, compared with the seminoma ones. Read More

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http://dx.doi.org/10.3390/ijms20020320DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358843PMC
January 2019
2 Reads

New Anti-Cancer Strategies in Testicular Germ Cell Tumors.

Recent Pat Anticancer Drug Discov 2019 ;14(1):53-59

Institute of Endocrinology and Experimental Oncology of the CNR c / o Department of Molecular Medicine and Medical Biotechnology, School of Medicine and Surgery of Naples, University of Naples 'Federico II', Naples, Italy.

Background: The most common solid malignancy of young men aged 20 to 34 years is testicular germ cell tumor. In addition, the incidence of these tumors has significantly increased throughout the last years. Testicular germ cell tumors are classified into seminoma and nonseminoma germ cell tumors, which take in yolk sac tumor, embryonal cell carcinoma, choriocarcinoma, and teratoma. Read More

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http://www.eurekaselect.com/168893/article
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http://dx.doi.org/10.2174/1574892814666190111120023DOI Listing
January 2019
26 Reads

Differential Zika Virus Infection of Testicular Cell Lines.

Viruses 2019 01 9;11(1). Epub 2019 Jan 9.

Biology of Vector-Borne Viruses Section, Laboratory of Virology, Rocky Mountain Laboratories, NIAID/NIH, Hamilton, MT 59840, USA.

Background: Zika virus is a mosquito-borne flavivirus responsible for recent outbreaks of epidemic proportions in Latin America. Sexual transmission of the virus has been reported in 13 countries and may be an important route of infection. Sexual transmission of ZIKV has mostly been male-to-female, and persistence of viral RNA in semen for up to 370 days has been recorded. Read More

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http://dx.doi.org/10.3390/v11010042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356326PMC
January 2019
2 Reads

Current controversies on the role of lymphadenectomy for testicular cancer for the journal: Urologic Oncology: Seminars and Original Investigations for the special seminars section on the role of lymphadenectomy for urologic cancers.

Urol Oncol 2019 Jan 7. Epub 2019 Jan 7.

Department of Urology, Indiana University School of Medicine, Indianapolis, IN.

The role of surgery in the locoregional management of many solid tumors has long been established. For testicular cancer, the incorporation of lymphadenectomy has played an important part in generating long-term survival outcomes in excess of 90% for germ cell tumor patients. In this review, we address several clinical scenarios in which lymphadenectomy at times is underutilized, and others ill advised. Read More

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http://dx.doi.org/10.1016/j.urolonc.2018.12.021DOI Listing
January 2019
6 Reads

Leptin Receptor as a Potential Target to Inhibit Human Testicular Seminoma Growth.

Am J Pathol 2019 Mar 2;189(3):687-698. Epub 2019 Jan 2.

Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende, Italy. Electronic address:

Although in past decades the adipokine leptin and its own receptor have been considered as significant cancer biomarkers, their potential involvement in human testicular seminoma growth and progression remains unexplored. Here, we showed that the expression of leptin and its receptor was significantly higher in human testicular seminoma compared with normal adult testis. Human seminoma cell line TCam-2 also expressed leptin along with the long and short isoforms of leptin receptor, and in response to leptin treatment showed enhanced activation of its downstream effectors. Read More

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http://dx.doi.org/10.1016/j.ajpath.2018.11.012DOI Listing
March 2019
4 Reads

Ambiguous presentation of an intra-abdominal testicular seminoma in a 40-year-old man: a case report.

J Med Case Rep 2019 Jan 4;13(1). Epub 2019 Jan 4.

St Elizabeth Catholic General Hospital and Cardiac Centre, Shisong, Northwest Region, Cameroon.

Background: Cryptorchidism is the most common congenital malformation of the male genitourinary tract. The cryptorchid testis is most often located in the inguinal canal; however, intra-abdominal locations are not rare. The risk of malignancy in an undescended testis is 10% with the highest risk in an intra-abdominal testis. Read More

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http://dx.doi.org/10.1186/s13256-018-1917-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320594PMC
January 2019
3 Reads

New Insights on the Mechanisms Affecting Fertility in Men with Non-Seminoma Testicular Cancer before Cancer Therapy.

World J Mens Health 2018 Dec 21. Epub 2018 Dec 21.

American Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, USA.

Purpose: Patients with non-seminoma testicular cancer (NSTC) cancer can be subfertile or infertile, and present reduced sperm quality, but the underlying mechanisms are unknown. The aim of this study was to compare the sperm proteome of patients with NSTC, who cryopreserved their sperm before starting cancer treatment, with that from healthy fertile men.

Materials And Methods: Semen volume, sperm motility and sperm concentration were evaluated before the cryopreservation of samples from patients with NSTC (n=15) and the control group (n=15). Read More

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http://dx.doi.org/10.5534/wjmh.180099DOI Listing
December 2018
5 Reads

Paraneoplastic recurrent tumefactive demyelination in a 62-year-old man with metastatic seminoma.

Neurol Neuroimmunol Neuroinflamm 2019 Jan 13;6(1):e527. Epub 2018 Dec 13.

Ottawa Hospital, Division of Neurology (S.T., P.R.B.); The Children's Hospital of Eastern Ontario (I.H.); The Ottawa Hospital (J.W.), Department of Pathology and Laboratory Medicine; and The Ottawa Hospital Research Institute (P.R.B.), ON, Canada.

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http://dx.doi.org/10.1212/NXI.0000000000000527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299676PMC
January 2019
3 Reads

[Temporary Bypass with 5-Fr Catheter for Reconstruction of Superior Vena Cava].

Kyobu Geka 2018 12;71(13):1077-1080

Division of Thoracic Surgery, Kobe University, Kobe, Japan.

A 21-year-old man was referred to our hospital because of an abnormal shadow on a routine chest radiogram. Enhanced computed tomography showed an 83×74 mm mass in the anterior mediastinum, with invasion of the superior vena cava (SVC). Surgical resection with sternotomy was performed. Read More

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December 2018
16 Reads

A Qualitative Analysis of the Impact of Carboplatin AUC 10 on Physical, Work Functioning and Bone Marrow Toxicity Among Seminoma Patients - A Single-centre Experience.

In Vivo 2019 Jan-Feb;33(1):233-237

Department of Medical Oncology, Mount Vernon Cancer Centre, Northwood, U.K.

Background: Single-agent carboplatin at area under the curve 10 (AUC10) is an effective treatment for metastatic seminoma. As far as we are aware of, there have been no studies reporting its effects on short-term quality of life. The objective was to study the efficacy, safety and tolerability, using health-related quality of life, of carboplatin AUC10 chemotherapy in patients with metastatic seminoma. Read More

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http://iv.iiarjournals.org/lookup/doi/10.21873/invivo.11465
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http://dx.doi.org/10.21873/invivo.11465DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364087PMC
April 2019
18 Reads

Pure Seminoma and Concurrent Aggressive Lymphoma: Case Report of a Patient With Persistent Müllerian Duct Syndrome.

Clin Genitourin Cancer 2018 Dec 5. Epub 2018 Dec 5.

Department of Medical Oncology, Centre Hospitalier Lyon Sud, Institut de cancérologie des Hospices Civils de Lyon (IC-HCL), Pierre-Bénite, France; UMR INSERM 1052, CNRS 5286, Centre de recherche en cancérologie de Lyon (CRCL), Lyon, France. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15587673183077
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http://dx.doi.org/10.1016/j.clgc.2018.11.019DOI Listing
December 2018
9 Reads

cd44 deletion suppresses atypia in the precancerous mouse testis.

Mol Carcinog 2018 Dec 23. Epub 2018 Dec 23.

Leibniz Institute on Aging-Fritz Lipmann Institute, Jena, Germany.

Loss-of-function of RHAMM causes hypofertility and testicular atrophy in young mice, followed by germ cell neoplasia in situ (GCNIS) of the testis, cellular atypia, and development of the testicular germ cell tumor (TGCT) seminoma. These pathologies reflect the risk factors and phenotypes that precede seminoma development in humans and-given the high prevalence of RHAMM downregulation in human seminoma-link RHAMM dysfunction with the aetiology of male hypofertility and GCNIS-related TGCTs. The initiating event underlying these pathologies, in RHAMM mutant testis, is premature displacement of undifferentiated progenitors from the basal compartment. Read More

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http://dx.doi.org/10.1002/mc.22961DOI Listing
December 2018
5 Reads

Loss of Nuclear Functions of HOXA10 Is Associated With Testicular Cancer Proliferation.

Front Oncol 2018 7;8:594. Epub 2018 Dec 7.

Department of Urologic Sciences, Vancouver Prostate Centre, The University of British Columbia, Vancouver, BC, Canada.

HOXA10 is a key transcriptional factor that regulates testis development as reported from previous transgenic mouse models and human inherited diseases. However, whether it also plays important roles in promoting the development of testicular cancer is not well-understood. To study the expression of HOXA10 and its regulated signaling pathways in testicular cancers. Read More

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http://dx.doi.org/10.3389/fonc.2018.00594DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292994PMC
December 2018
4 Reads

Incidence of testicular tumor subtypes according to the updated WHO classification, North Rhine-Westphalia, Germany, 2008-2013.

Andrology 2018 Dec 21. Epub 2018 Dec 21.

Cancer Registry of North Rhine-Westphalia, Muenster, Germany.

Background: In 2016, the WHO introduced an updated classification for testicular tumors. The application of this updated classification to cancer registry data requires some recoding of tumors.

Objectives: The aim of this study was to provide up-to-date population-based incidence estimates of subtypes of testicular germ cell tumors (TGCT) according to the updated classification. Read More

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http://dx.doi.org/10.1111/andr.12565DOI Listing
December 2018
1 Read