6,343 results match your criteria Seminoma

Choroidal Metastasis Secondary to Testicular Mature Teratoma: A Case Report.

Ocul Oncol Pathol 2021 Mar 4;7(2):85-90. Epub 2021 Jan 4.

Sheffield Ocular Oncology Service, Department of Ophthalmology, Sheffield Teaching Hospitals, Sheffield, United Kingdom.

We report a case of a choroidal metastasis secondary to testicular mature teratoma, a subtype of non-seminoma germ cell tumours, in a young adult male. The choroidal metastasis was treated successfully with bleomycin, etoposide, and cisplatin chemotherapy without the need for adjuvant radiotherapy. This represents a rare case of mature teratoma metastasizing to the choroid and one of very few reported testicular germ cell tumours to achieve normal or near normal visual acuity with chemotherapy alone despite severe macular disease at presentation. Read More

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Clear identification of the rare solitary external iliac lymph node metastasis of testicular cancer by using indocyanine green fluorescence guidance.

IJU Case Rep 2021 May 24;4(3):163-166. Epub 2021 Feb 24.

Department of Urology The Jikei University School of Medicine Tokyo Japan.

Introduction: There are few reports on indocyanine green fluorescence-guided surgery in testis-related diseases.

Case Presentation: A 38-year-old man underwent orchiectomy for left testicular cancer. Pathological diagnosis was pT1 seminoma. Read More

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The m6A methyltransferase METTL3 regulates autophagy and sensitivity to cisplatin by targeting ATG5 in seminoma.

Transl Androl Urol 2021 Apr;10(4):1711-1722

Department of Urology, The Third Xiangya Hospital of Central South University, Changsha, China.

Background: Our previous work shows Autophagy enhanced resistance to cisplatin in seminoma. The expression of the N6-methyladenosine (m6A) methyltransferases METTL3 was significantly increased in the cisplatin-resistant TCam-2 cell line of seminoma. We aimed to investigate the role of m6A methylation in autophagy and the chemosensitivity of seminoma cells. Read More

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SSX C-Terminus is a Useful Diagnostic Biomarker for Spermatocytic Tumour.

Histopathology 2021 May 7. Epub 2021 May 7.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.

Aims: Spermatocytic tumour (ST) is a rare testicular germ cell neoplasm that can be challenging to diagnose and for which there are few confirmatory biomarkers. Like normal spermatogonia, STs are known to express SSX proteins. Recently, a novel SSX antibody directed against the C-terminus (SSX_CT) of SSX1, SSX2 and SSX4, has emerged as a reliable biomarker for these SSX proteins and synovial sarcoma. Read More

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Radiotherapy as a Single Modality in Primary Seminoma of the Prostate.

Cureus 2021 Apr 2;13(4):e14264. Epub 2021 Apr 2.

Medical Oncology, Grand River Regional Cancer Centre, Kitchener, CAN.

Extragonadal germ cell tumors (EGCTs) are uncommon, and those involving the prostate are rare. We report on a primary seminoma of the prostate in a 56-year-old male presenting with scrotal pain, urinary frequency and urgency, and erectile dysfunction. Digital rectal examination revealed a hard, markedly enlarged prostate projecting posteriorly into the rectum. Read More

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[Active surveillance for testicular tumors: adherence and safety.]

Arch Esp Urol 2021 May;74(4):397-403

Servicio de Urología. Hospital Alemán de Buenos Aires. Ciudad de Buenos Aires. Argentina.

Introduction: The active surveillance (AS) of testicular tumors (seminoma and non-seminoma) is the most frequent management option in the stage I disease. Relapses generally occurred within the first 3 years and <5% appear after this time cut-off point is fulfilled. Therefore, the adherence is one of the most important pillars in the AS protocol. Read More

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Dataset of testicular germ cell tumors (TGCT) risk associated with serum polychlorinated biphenyl (PCB) by age at diagnosis and histologic types.

Data Brief 2021 Jun 27;36:107014. Epub 2021 Mar 27.

School of Public Health, Brown University, Providence, RI 02903, USA.

In a population-based case control study of testicular germ cell tumors (TGCT), we reported a strong positive association between serum levels of Wolff's Group 1 (potentially estrogenic) polychlorinated biphenyl (PCBs) and risk of TGCT, and the observed associations were similar for both seminoma and non-seminoma. While the observed specific associations between TGCT and Wolff's Group 1 PCBs cannot be easily explained by bias or confounding, a question can still be asked, that is, could the relationship between PCBs and TGCT differ by age at diagnosis? PCBs tend to bioaccumulate, with more heavily chlorinated PCB congeners tending to have longer half-lives. Half-lives of PCB congeners were reported ranging from 4. Read More

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Histological Features of Sporadic and Familial Testicular Germ Cell Tumors Compared and Analysis of Age-Related Changes of Histology.

Cancers (Basel) 2021 Apr 1;13(7). Epub 2021 Apr 1.

Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20850, USA.

This study aimed to compare histological features of familial and sporadic testicular germ cell tumors (TGCTs) and surrounding parenchyma, since discriminating features might be etiologically relevant and clinically useful. The study of parenchyma was prompted by reports claiming a higher prevalence of testicular microlithiasis in familial cases. Histological features of TGCTs and surrounding parenchyma of 296 sporadic and 305 familial cases were compared. Read More

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Paraneoplastic Neurological Syndromes and Beyond Emerging With the Introduction of Immune Checkpoint Inhibitor Cancer Immunotherapy.

Front Neurol 2021 9;12:642800. Epub 2021 Apr 9.

Departments of Neurology and Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN, United States.

Paraneoplastic neurological syndromes are more commonly seen with malignancies such as small cell lung cancer, thymoma, gynecological malignancies, and breast cancer as well as seminoma. With the introduction of immune checkpoint inhibitor (ICI) cancer immunotherapy we see an increase of autoimmune neurological complications in patients with malignancies not traditionally associated with paraneoplastic neurological syndromes, such as melanoma and renal cell carcinoma. Immune checkpoint inhibitors enhance antitumor immune responses resulting often in immune-related adverse effects that can affect any organ, including the central and peripheral nervous system, neuromuscular junction and muscle. Read More

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Testicular Tumors: A Contemporary Update on Morphologic, Immunohistochemical and Molecular Features.

Adv Anat Pathol 2021 Apr 12. Epub 2021 Apr 12.

Department of Pathology & Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN.

Testicular tumors are incredibly diverse and one of the most challenging areas in surgical pathology. Because of the rarity and overlapping features with numerous entities occurring in the testis and paratestis, these tumors pose a diagnostic challenge even to the most experienced general pathologists. In 2016, the latest "World Health Organization (WHO) classification of testicular tumors" was released, which incorporated several updates to the previous 2004 classification system. Read More

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Clinical characteristics and management of Turner patients with a small supernumerary marker chromosome.

Gynecol Endocrinol 2021 Apr 19:1-5. Epub 2021 Apr 19.

Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.

Objective: To summarize the clinical characteristics of Turner syndrome (TS) with a small supernumerary marker chromosome (sSMC) and discuss the clinical significance and management of TS patients with sSMC.

Methods: A retrospective analysis was conducted on the clinical data of 244 patients with disorders of sexual development admitted to Peking Union Medical College Hospital from February 1984 to July 2020.

Results: Among the 244 patients with a disorder of sexual development, 69 cases of TS were identified in which 13 patients had sSMC. Read More

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Mismatch repair deficiency occurs very rarely in seminomas.

Transl Androl Urol 2021 Mar;10(3):1048-1055

Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Background: Dense tumor-associated lymphocyte infiltration is linked to mismatch repair (MMR) deficiency in colorectal and endometrial cancer. MMR deficiency is of high clinical importance as MMR deficient cancers tend to react favorably to treatment with immune checkpoint inhibitors. Strong lymphocytic infiltration is a morphological hallmark of seminomas. Read More

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Primary Testicular Neuroendocrine Tumor Coexisting With Seminoma Sharing Germ Cell Origin.

Int J Surg Pathol 2021 Apr 13:10668969211008980. Epub 2021 Apr 13.

118084Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan.

A 40-year-old, male, Japanese patient presented with the complaint of painless, right testicular swelling. Tumor markers for testicular cancer were normal. He underwent radical orchiectomy with the clinical diagnosis of stage I seminoma. Read More

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The Potential of Artificial Intelligence to Detect Lymphovascular Invasion in Testicular Cancer.

Cancers (Basel) 2021 Mar 16;13(6). Epub 2021 Mar 16.

Department of Cellular Pathology, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford OX3 9DU, UK.

Testicular cancer is the most common cancer in men aged from 15 to 34 years. Lymphovascular invasion refers to the presence of tumours within endothelial-lined lymphatic or vascular channels, and has been shown to have prognostic significance in testicular germ cell tumours. In non-seminomatous tumours, lymphovascular invasion is the most powerful prognostic factor for stage 1 disease. Read More

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Testicular seminoma with pagetoid spread into the vas deferens: A rare histopathological presentation.

Andrologia 2021 Apr 1:e14061. Epub 2021 Apr 1.

Department of Urology, Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.

Testicular cancer, in particular testicular germ cell tumours, is the most common malignancy in young adult men. Defining prognosis and the best therapeutic strategy is challenging since accurate staging could be controversial. We report an unusual case of seminoma with pagetoid spread into the rete testis and, unexpectedly, also within the epithelium of the vas deferens, up to the margin of excision of the spermatic cord. Read More

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Primary mediastinal germ cell tumours: real world experience in the low middle income (LMIC) setting.

Ecancermedicalscience 2021 11;15:1186. Epub 2021 Feb 11.

Department of Medical Oncology, Christian Medical College and Hospital Vellore, Vellore 632004, India.

Purpose: Primary mediastinal germ cell tumours (PMGCTs) are rare; with limited data available about their outcomes and optimal treatment in the low middle income countries setting. We studied the clinical profile of patients with PMGCT treated at our centre in order to estimate their survival outcomes and to identify prognostic factors affecting the same.

Patients And Methods: Fifty-seven patients with PMGCTs treated between April 2001 and June 2019 were included. Read More

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February 2021

RNA-Binding Proteins Play an Important Role in the Prognosis of Patients With Testicular Germ Cell Tumor.

Front Genet 2021 11;12:610291. Epub 2021 Mar 11.

Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Testicular germ cell tumors (TGCTs) are common urological neoplasms in young adult males. The outcome of TGCT depends on pathologic type and tumor stage. RNA-binding proteins (RBPs) influence numerous cancers via post-transcriptional regulation. Read More

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Regressed Seminoma with Metastases to the Jejunum and Retroperitoneum.

Case Rep Oncol 2021 Jan-Apr;14(1):418-423. Epub 2021 Mar 12.

Department of Surgery, Kishiwada Tokushukai Hospital, Kishiwada, Japan.

A 66-year-old man with vomiting and weight loss was referred to our hospital. Abdominal computed tomography showed small bowel obstruction caused by a presumed small intestinal tumor. Single-balloon endoscopy showed an ulcerated tumor and marked stenosis of the jejunum. Read More

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Clonal derivation of sequential seminoma and acute megakaryoblastic leukaemia.

Ann Hematol 2021 May 24;100(5):1337-1339. Epub 2021 Mar 24.

Department of Medicine, Professorial Block, Queen Mary Hospital, Pokfulam Road, Hong Kong, China.

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Retroperitoneal extension of massive ulcerated testicular seminoma through the inguinal canal: A case report.

Arch Ital Urol Androl 2021 Mar 19;93(1):64-67. Epub 2021 Mar 19.

Department of Medical, Oral and Biotechnological Sciences, G. d'Annunzio University of Chieti, Urology Unit, SS. Annunziata Hospital, Chieti.

Introduction: Testicular cancers represent about 5% of all urological malignancies and 1-1.5% of all male neoplasms. Most of the testicular cancers are localized (68%) at diagnosis. Read More

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Survival and New Prognosticators in Metastatic Seminoma: Results From the IGCCCG-Update Consortium.

J Clin Oncol 2021 May 17;39(14):1553-1562. Epub 2021 Mar 17.

Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy. Current affiliation: Vita-Salute San Raffaele University and IRCCS San Raffaele Hospital and Scientific Institute, Milan, Italy.

Purpose: The classification of the International Germ-Cell Cancer Collaborative Group (IGCCCG) has been a major advance in the management of germ-cell tumors, but relies on data of only 660 patients with seminoma treated between 1975 and 1990. We re-evaluated this classification in a database from a large international consortium.

Materials And Methods: Data on 2,451 men with metastatic seminoma treated with cisplatin- and etoposide-based first-line chemotherapy between 1990 and 2013 were collected from 30 institutions or collaborative groups in Australia, Europe, and North America. Read More

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Does Testicular Seminoma Involve a Higher Predisposition Than Nonseminoma to Develop Contralateral Testicular Tumors?

J Clin Oncol 2021 Mar 16:JCO2003236. Epub 2021 Mar 16.

Klaus-Peter Dieckmann, PhD, Asklepios Klinik Altona, Urologische Abteilung, Hamburg, Germany.

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Complete androgen insensitivity syndrome with intra-abdominal seminoma in a phenotypic female: A rare presentation.

J Cancer Res Ther 2021 Jan-Mar;17(1):272-275

Department of Radiotherapy, Maulana Azad Medical College and Associated Lok Nayak Hospital, New Delhi, India.

Androgen insensitivity syndrome (AIS) is a rare, X-linked recessive disorder which causes alterations in androgen receptor gene leading to hormone resistance, which may present clinically under three phenotypes: complete AIS (CAIS), partial AIS, or mild AIS. The symptoms range from phenotypically normal males with impaired spermatogenesis to phenotypically normal women with primary amenorrhea. We report a case of a 35-year-old woman who was diagnosed with CAIS and presented with malignant transformation of the undescended testis. Read More

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Retroperitoneal lymph node dissection for testicular cancer in a patient with a double inferior vena cava.

IJU Case Rep 2021 Mar 31;4(2):86-88. Epub 2021 Jan 31.

Department of Urology University of Tsukuba Hospital Tsukuba Ibaraki Japan.

Introduction: A double inferior vena cava is a rare anomaly with an incidence ranging from 0.3% to 3.0%. Read More

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m6A RNA methylation regulators play an important role in the prognosis of patients with testicular germ cell tumor.

Transl Androl Urol 2021 Feb;10(2):662-679

Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Background: N6-methyladenosine (m6A) is found to be associated with promoting tumorigenesis in different types of cancers, however, the function of m6A-related genes in testicular germ cell tumors (TGCT) development remains to be illuminated. This study aimed to investigated the prognostic value of m6A RNA methylation regulators in TGCT.

Methods: We collected TGCT patients' information about clinicopathologic parameters and twenty-two m6A regulatory genes expression from The Cancer Genome Atlas (TCGA) database and Genotype-Tissue Expression (GTEx). Read More

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February 2021

28-Year-Old Man With an Enlarged Left Testicle.

Mayo Clin Proc 2021 04 10;96(4):1047-1051. Epub 2021 Mar 10.

Advisor to residents and Consultant in General Internal Medicine, Mayo Clinic, Rochester, MN. Electronic address:

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Tumor markers andF-FDG PET/CT after orchiectomy in seminoma:Is there any correlation?

Rev Esp Med Nucl Imagen Mol 2021 Mar 8. Epub 2021 Mar 8.

Nuclear Medicine, University of Brescia, Spedali Civili Brescia, Brescia, Italia.

Objective: The aim of our study was to analyze the potential relationship between tumor markers and F-fluorodoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT) results in patients affected by seminoma.

Material And Methods: 65 F-FDG PET/CT scans of 41 patients with diagnosis of seminoma were analyzed and compared to alpha-fetoprotein (AFP) and human chorionic gonadotropin (hCG). PET/CT studies were analyzed qualitatively and measuring the maximum and mean standardized uptake value body weight max (SUV, SUV), maximum SUV lean body mass (SUV), maximum SUV body surface area (SUV), metabolic tumor volume (MTV) and total lesion glycolysis (TLG) of hypermetabolic lesions. Read More

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Primary Mediastinal Germ Cell Tumors-The University of Western Ontario Experience.

Curr Oncol 2020 12 8;28(1):78-85. Epub 2020 Dec 8.

Department of Surgery, Urology Division, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON N6A 5W9, Canada.

Extragonadal germ cell tumors account for 2-5.7% of germ cell tumors (GCTs). Of these, primary mediastinal GCTs (PMGCTs) are responsible for 16-36% of cases. Read More

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December 2020

Expression of programmed death ligand-1 (PD-L1) in metastatic and postchemotherapy viable testicular germ cell tumors.

Urol Oncol 2021 Mar 5. Epub 2021 Mar 5.

Department of Surgery, Faculty of Medicine, CHU de Québec-Université Laval. Electronic address:

Introduction: Chemotherapy for testicular germ cell tumors (GCT) is highly effective, with few patients who do not respond. Clinical studies to evaluated novel treatments are challenging given the rarity of these patients. Therefore, we sought to evaluate PD-L1 staining on metastatic and postchemotherapy viable testicular GCTs as a surrogate for potential benefit for immunotherapy targeting the PD-1/PD-L1 axis. Read More

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Assessment of Prognostic Factors of Racial Disparities in Testicular Germ Cell Tumor Survival in the United States (1992-2015).

Biomed Environ Sci 2021 Feb;34(2):152-162

State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai 200433, China;Shanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center at Shanghai, Shanghai 200000, China.

Objective: Testicular germ cell tumors (TGCT) are the most common cancer among men aged 15 to 39 years. Previous studies have considered factors related to TGCT survival rate and race/ethnicity, but histological type of the diagnosed cancer has not yet been thoroughly assessed.

Methods: The data came from 42,854 eligible patients from 1992 to 2015 in the Surveillance Epidemiology and End Results 18. Read More

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February 2021