5,915 results match your criteria Seminoma


Clinicopathological Significance and Antitumor Effect of MPHOSPH1 in Testicular Germ Cell Tumor.

J Cancer 2018 31;9(23):4440-4448. Epub 2018 Oct 31.

Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.

MPHOSPH1, which is one of the kinesin superfamily proteins, has been reported to play an essential role in the carcinogenesis and progression of several kinds of cancers. MPHOSPH1 has also been suggested to be involved in STAT3 phosphorylation in hepatocellular carcinoma. However, the biological behavior of MPHOSPH1 in testicular germ cell tumors (TGCTs) is unclear at present. Read More

View Article
October 2018

Deep learning for detecting tumour-infiltrating lymphocytes in testicular germ cell tumours.

J Clin Pathol 2018 Dec 5. Epub 2018 Dec 5.

Nuffield Department of Surgical Sciences and NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK.

Aims: To evaluate if a deep learning algorithm can be trained to identify tumour-infiltrating lymphocytes (TILs) in tissue samples of testicular germ cell tumours and to assess whether the TIL counts correlate with relapse status of the patient.

Methods: TILs were manually annotated in 259 tumour regions from 28 whole-slide images (WSIs) of H&E-stained tissue samples. A deep learning algorithm was trained on half of the regions and tested on the other half. Read More

View Article
December 2018

CSE1L participates in regulating cell mitosis in human seminoma.

Cell Prolif 2018 Nov 28:e12549. Epub 2018 Nov 28.

Family Planning Research Institute, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Objectives: CSE1L has been reported to be highly expressed in various tumours. Testicular germ cell tumours are common among young males, and seminoma is the major type. However, whether CSE1L has functions in the seminoma is unclear. Read More

View Article
November 2018

Delivery of chemotherapy for testicular cancer in routine practice: A population-based study.

Urol Oncol 2018 Nov 23. Epub 2018 Nov 23.

Division of Cancer Care and Epidemiology, Queen's Cancer Research Institute, Kingston, Canada; Department of Oncology, Queen's University, Kingston, Canada; Department of Public Health Sciences, Queen's University, Kingston, Canada. Electronic address:

Introduction: Maintenance of chemotherapy dose intensity is a cornerstone of management in testicular germ cell tumors. We describe chemotherapy delivery and outcomes of patients in routine practice.

Methods: The Ontario Cancer Registry was linked to electronic records of treatment to identify patients diagnosed with testicular cancer treated with orchiectomy and chemotherapy from 2005 to 2010. Read More

View Article
November 2018
1 Read

[French ccAFU guidelines - Update 2018-2020: Testicular germ cell tumors].

Prog Urol 2018 Nov 27;28(12S):S147-S164. Epub 2018 Oct 27.

Comité de cancérologie de l'Association française d'urologie, groupe organes génitaux externes, maison de l'urologie, 11, rue Viète, 75017 Paris, France; Service d'urologie, hôpital européen Georges-Pompidou, université Paris Descartes, AP-HP, 75015 Paris, France.

Objective: To update French guidelines concerning testicular germ cell cancer.

Methods: Comprehensive Medline search between 2016 and 2018 upon diagnosis, treatment and follow-up of testicular germ cell cancer and treatments toxicities. Level of evidence was evaluated. Read More

View Article
November 2018
1 Read

Active surveillance as a successful management strategy for patients with clinical stage I germ cell testicular cancer.

Clin Transl Oncol 2018 Nov 23. Epub 2018 Nov 23.

Medical Oncology Department, Virgen del Rocío University Hospital, Seville, Spain.

Background: Cancer-specific survival for patients with clinical stage I (CSI) germ cell testicular cancer (GCTC) is outstanding after inguinal orchidectomy regardless the treatment utilized. This study evaluated whether active surveillance (AS) of such patients yielded similar health outcomes to other therapeutic strategies such as adjuvant chemotherapy, radiotherapy or primary retroperitoneal lymphadenectomy as described in the literature.

Patients And Methods: Patients with CSI GCTC were screened between January 2012 and December 2016. Read More

View Article
November 2018
4 Reads

Mediastinal seminoma presenting as a neck mass falsely diagnosed as anaplastic thyroid carcinoma: A case report.

Diagn Cytopathol 2018 Nov 23. Epub 2018 Nov 23.

Department of Lab Medicine and Pathology - Histopathology Section, Hamad Medical Corporation, Doha, State of Qatar.

Germ cell tumors can occur in the mediastinum. They account for about 20% of tumors at this location. The majority are located in the anterior mediastinum and usually occur in young adult males. Read More

View Article
November 2018
6 Reads

Thymic inflammatory pseudotumor with multilocular thymic cyst caused by immunoglobulin G4-related disease.

Thorac Cancer 2018 Nov 23. Epub 2018 Nov 23.

Department of Oncology, Immunology and Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.

A 44-year-old man was referred to our hospital after an anterior mediastinal tumor was noted on computed tomography during follow-up observation after left testicular seminoma resection. Chest computed tomography revealed an enhanced mass measuring 33 x 16 x 15 mm at the anterior mediastinum. Chest magnetic resonance imaging revealed high signal intensity on T2-weighted imaging, and F  fluorodeoxyglucose-positron emission tomography showed a maximum standardized uptake of 12. Read More

View Article
November 2018
5 Reads

Lymph node imaging in testicular cancer.

Transl Androl Urol 2018 Oct;7(5):864-874

Urologic Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

Testicular cancer is a rare malignancy mainly affecting young men. Survival for testicular cancer remains high due to the effectiveness of multimodal treatment options. Accurate imaging is imperative to both treatment and follow-up. Read More

View Article
October 2018
2 Reads

Current controversies on the role of retroperitoneal lymphadenectomy for testicular cancer.

Urol Oncol 2018 Nov 13. Epub 2018 Nov 13.

Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY. Electronic address:

Retroperitoneal lymph node dissection (RPLND) is an important component of the multimodal treatment which cures most patients diagnosed with testicular germ cell tumors. Considering the high cure rates achieved, research focus in recent years has been directed toward improving quality of life and decreasing long-term treatment related sequelae. Consequently, the role of RPLND has evolved over the past 3 decades in both low-stage and advanced testicular cancer. Read More

View Article
November 2018
8 Reads

Long non-coding RNA H19 promotes TDRG1 expression and cisplatin resistance by sequestering miRNA-106b-5p in seminoma.

Cancer Med 2018 Nov 14. Epub 2018 Nov 14.

Department of Urology, The Third Xiangya Hospital of Central South University, Changsha, China.

The role of TDRG1 in tumorigenesis and the progression of seminoma, as well as its role in regulating chemosensitivity of seminoma to cisplatin through the PI3K/Akt/mTOR signaling pathway, has been previously defined. However, the detailed mechanism underlying TDRG1 expression and concomitant chemoresistance conditions are unknown. Furthermore, it has been reported that non-protein-coding RNAs play an important role in a variety of vital processes including cellular chemosensitivity. Read More

View Article
November 2018
2 Reads

Sentinel Node Biopsy in Clinical Stage I Testicular Cancer Enables Early Detection of Occult Metastatic Disease.

BJU Int 2018 Nov 11. Epub 2018 Nov 11.

Department of Oncological Urology, UMC Utrecht Cancer Center, University Medical Center Utrecht, Utrecht, The Netherlands.

Objectives: To report the long-term results of the sentinel node approach in clinical stage I testicular tumour patients in our facility.

Patients And Methods: Analysis of 27 consecutive patients suspected of clinical stage I testicular germ cell tumour and treated with a sentinel node procedure at our tertiary referral centre. Sentinel nodes were identified using lymphoscintigraphy with or without single photo emission computed tomography with computed tomography. Read More

View Article
November 2018
5 Reads

Molecular Imaging for Evaluation of Viable Testicular Cancer Nodal Metastases.

Curr Urol Rep 2018 Nov 9;19(12):110. Epub 2018 Nov 9.

The James Buchanan Brady Urological Institute and Department of Urology, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Marburg 144, Baltimore, MD, 21287, USA.

Purpose Of Review: Determining the metastatic viability of suspicious retroperitoneal nodes in testicular cancer with conventional imaging is challenging. The aim of this report is to review recent evidence in the utilization of novel imaging modalities to assess viable testicular cancer nodal metastases.

Recent Evidence: Testicular germ cell tumors (TCGTs) follow a predictable lymphatic metastatic spread to the retroperitoneum. Read More

View Article
November 2018
5 Reads

βcatenin is a marker of poor clinical characteristics and suppressed immune infiltration in testicular germ cell tumors.

BMC Cancer 2018 Nov 3;18(1):1062. Epub 2018 Nov 3.

2nd Department of Oncology, Faculty of Medicine, Comenius University and National Cancer Institute, Klenova 1, 833 10, Bratislava, Slovak Republic.

Background: WNT/βcatenin (WNTβ) pathway is activated in early stages of embryonic development. We aimed to evaluate the significance of βcatenin in germ cell tumors (GCTs) and explore associations with the inflamed environment.

Methods: Surgical specimens from 247 patients were analyzed. Read More

View Article
November 2018
4 Reads

Testis sparing surgery for small testicular masses and frozen section assessment.

Cent European J Urol 2018 16;71(3):304-309. Epub 2018 Aug 16.

Department of Urology, Frimley Health NHS Foundation Trust, Wexham Park Hospital Slough, Berkshire, United Kingdom.

Introduction: We present our experience with patients who had suspected testicular masses, managed by a frozen section assessment and testicular sparing surgery.

Material And Methods: We performed a retrospective review of all patients over the last 5 years, who underwent a frozen section assessment and testicular sparing surgery for small testicular lesions. The frozen section assessment was compared with the final histology. Read More

View Article
August 2018
2 Reads

Testicular seminoma in the aged rat visualized by phase-contrast X-ray computed tomography.

Acta Radiol Open 2018 Sep 23;7(10):2058460118806657. Epub 2018 Oct 23.

School of Allied Health Sciences, Kitasato University, Kanagawaken, Japan.

Spontaneously growing testicular seminoma in the aged rat was imaged by one of the most sensitive imaging modalities, namely, phase-contrast X-ray computed tomography (CT) with crystal X-ray interferometry. Phase-contrast X-ray CT clearly depicted the detailed inner structures of the tumor and provided 20× magnified images compared to light-microscopic images. Phase-contrast X-ray CT images are generated based on density variations in the object, whereas pathological images are based on differentiation of cellular structures, such as the cellular nuclei and cytoplasm. Read More

View Article
September 2018
1 Read

[Positron emission tomography in germ cell tumors in men : Possibilities and limitations].

Urologe A 2018 Oct 29. Epub 2018 Oct 29.

Klinik für Onkologie, Hämatologie und Knochenmarktransplantation mit Abteilung für Pneumologie, Universitätsklinikum Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Deutschland.

Background: Conventional radiographic imaging may fail to safely distinguish clinical stage I from stage IIA germ cell cancer, to localize isolated tumor marker relapses, and to equivocally identify the viability of postchemotherapy residual masses.

Objectives: To provide an overview of the diagnostic value and limitations of functional imaging by positron emission tomography with 2‑deoxy-2-[fluorine-18]fluoro-D-glucose with computed tomography (F-FDG-PET-CT) in male germ cell cancer.

Materials And Methods: A narrative review based on a literature search of PubMed/MEDLINE for original articles published from 1990-2018 and conference proceedings of ASCO (American Society of Clinical Oncology) and EAU (European Association of Urology) annual meetings 2014-2017 is presented. Read More

View Article
October 2018
3 Reads

CK7, inhibin, and p63 in testicular germ cell tumor: superior markers of Choriocarcinoma compared to β-hCG.

Hum Pathol 2018 Oct 22. Epub 2018 Oct 22.

Department of Pathology, The Ohio State University Medical Center, 410 W 10(th) Ave., 401 Doan Hall, Columbus, OH 43210. Electronic address:

Choriocarcinoma can be difficult to differentiate from other subtypes of testicular germ cell tumor and can occur unexpectedly in a distant, late metastasis. The aim of this investigation was to identify a marker superior to β-hCG for choriocarcinoma. 62 primary and metastatic testicular germ cell tumors (27 choriocarcinomas, 19 yolk sac tumors, 29 embryonal carcinomas, 28 seminomas, 22 teratomas, 3 epithelioid trophoblastic tumors (ETT)), were analyzed for immunohistochemical expression of CK7, inhibin, p63, and β-hCG. Read More

View Article
October 2018
7 Reads
2.770 Impact Factor

N-cadherin expression in primary and metastatic testicular germ cell tumors.

J BUON 2018 Jul-Aug;23(4):1125-1129

Department of Surgical Pathology, Uludag University School of Medicine, Bursa, Turkey.

Purpose: Upregulation of N-cadherin in epithelial tumor cells has been reported to enhance the invasive process. Although the distribution of N-cadherin in the normal testis was demonstrated, there is no adequate information regarding its presence in testicular germ cell tumors (GCTs). Our purpose was to examine the expression and localization of N-cadherin in germ cell tumors of the testis and share our experience. Read More

View Article
October 2018
2 Reads

Exploring the spectrum of late effects following radical orchidectomy for stage I testicular seminoma: a systematic review of the literature.

Support Care Cancer 2018 Oct 22. Epub 2018 Oct 22.

Eastern Health Cancer Services, Level 4, 8 Arnold St., Box Hill, VIC, 3128, Australia.

Purpose: Testicular seminomas occur in young men and are highly curable. Toxicities following treatment for men with extensive stage II-III seminomas may cause long-term morbidities. However, it is not clear whether the risk of late effects also increases following surgery for testis-confined seminoma. Read More

View Article
October 2018
5 Reads

Sperm imprinting integrity in seminoma patients?

Clin Epigenetics 2018 Oct 19;10(1):125. Epub 2018 Oct 19.

Université Bourgogne Franche-Comté-Equipe Génétique des Anomalies du Développement (GAD) INSERM UMR1231, 2 Rue Angélique Ducoudray, F-21000, Dijon, France.

Background: Testicular germ cell tumor such as seminoma is strongly associated with male reproductive problems commonly associated with the alteration of sperm parameters as described in testicular dysgenesis syndrome. Interestingly, numerous studies have reported that the precursor of germ cell cancer, germ cell neoplasia in situ (GCNIS), present similarities to fetal gonocytes, specifically characterized by global DNA hypomethylation particularly on imprinting sequences. These disorders may have a common origin derived from perturbations of embryonal programming during fetal development. Read More

View Article
October 2018
4 Reads

Spermatogenesis in Testicles with Germ Cell Tumors.

Isr Med Assoc J 2018 Oct;20(10):642-644

Department of Urology, Kaplan Medical Center, Rehovot, Israel.

Background: Almost 50% of patients with germ-cell tumors (GCT) are subfertile, and every step of the treatment may further impair fertility. As a result, sperm banking is often advised prior to radical orchiectomy. However, whether affected testes contribute to fertility is unclear. Read More

View Article
October 2018
6 Reads

Manubrium resection and reconstruction for mediastinal tumor: a case report.

Rev Port Cir Cardiotorac Vasc 2018 Jan-Jun;25(1-2):87-89

Cardiothoracic Surgery Department, Hospital Beatriz Ângelo, Loures, Portugal.

Primary mediastinal tumours with chest wall involvement represent technical challenges that may offer a survival benefit. Reconstruction with osteossynthesis material, bioprosthesis and muscle flaps is indicated to re-establish the excised component function. We report a case of a 30-year-old male with a primary mediastinal seminoma operated after chemotherapy with need for en bloc resection of the residual mass and manubrium with chest wall reconstruction. Read More

View Article
June 2018
2 Reads

Activin A target genes are differentially expressed between normal and neoplastic adult human testes: clues to gonocyte fate choice.

Andrology 2018 Oct 13. Epub 2018 Oct 13.

Centre for Reproductive Health, Hudson Institute of Medical Research, Clayton, VIC, Australia.

Background: Human testicular germ cell tumours (TGCT) arise from germ cell neoplasia in situ (GCNIS) cells that originate from foetal germ cell precursors. Activin A is central to normal foetal testis development, and its dysregulation may contribute to TGCT aetiology.

Objective: (i) To test whether the expression profiles of activin A targets in normal and neoplastic human testes indicates functional links with TGCT progression. Read More

View Article
October 2018
1 Read

Malignant Sertoli cell tumor of the testis masquerading as seminoma with bone metastasis.

Indian J Pathol Microbiol 2018 Oct-Dec;61(4):596-599

Department of Surgical Oncology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India.

Sex cord-stromal tumors of the testes are rare malignancies as compared to germ cell tumors. Pure Sertoli cell tumors are still rare representing <1% of testicular cancers and the malignant forms are too rare. Furthermore, the occurrence of metastasis in such cases is extremely rare with <30 cases reported in literature so far to the best of our knowledge. Read More

View Article
October 2018
9 Reads

Ultrasonographic features of testicular metastasis from renal clear cell carcinoma that mimics a seminoma: A case report.

Medicine (Baltimore) 2018 Oct;97(40):e12728

Department of Ultrasound, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Rationale: Testicular metastases from renal cell carcinoma (RCC) are extremely rare. To the best of our knowledge, only 35 cases have been described in the literatures.

Patient Concerns: A 64-year-old male presented to our urology clinic for a palpable painless mass on his right side of the scrotum by self-examination 1 week ago, with a general abdominal ultrasonographic report showing a mass in his right kidney. Read More

View Article
October 2018
2 Reads

Questioning the Value of Fluorodeoxyglucose Positron Emission Tomography for Residual Lesions After Chemotherapy for Metastatic Seminoma: Results of an International Global Germ Cell Cancer Group Registry.

J Clin Oncol 2018 Oct 4:JCO1800210. Epub 2018 Oct 4.

Richard Cathomas, Kantonsspital Graubünden, Chur; Dirk Klingbiel, Swiss Group for Clinical Cancer Research Coordinating Center; Silke Gillessen, University of Bern; Jörg Beyer, Inselspital, Bern University Hospital, University of Bern, Bern; Christian Fankhauser, University of Zürich, Zürich; Silke Gillessen, Kantonsspital St Gallen, St Gallen, Switzerland; Brandon Bernard, Dana-Farber Cancer Institute, Boston, MA; Anja Lorch, University of Düsseldorf, Düsseldorf; Christoph Oing, University Medical Center Hamburg-Eppendorf, Hamburg; Marcus Hentrich, Rotkreuzklinikum München, München, Germany; Xavier Garcia del Muro, Institute Catalan of Oncology, Bellvitge Biomedical Research Institute, University of Barcelona, Barcelona, Spain; Franco Morelli, Ospedale Casa Sollievo della Sofferenza, San Giovanni Rotondo; Ugo De Giorgi, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Istituto di Ricovero e Cura a Carattere Scientifico, Meldola, Italy; Mikhail Fedyanin, N.N. Blokhin National Medical Research Center of Oncology, Moscow, Russia; and Hege Sagstuen Haugnes, University Hospital of North Norway and Universitetet i Tromsø-The Arctic University, Tromsø, Norway.

Purpose: Residual lesions after chemotherapy are frequent in metastatic seminoma. Watchful waiting is recommended for lesions < 3 cm as well as for fluorodeoxyglucose (FDG) positron emission tomography (PET)-negative lesions ≥ 3 cm. Information on the optimal management of PET-positive residual lesions ≥ 3 cm is lacking. Read More

View Article
October 2018
1 Read

Seminoma component of mixed testicular germ cell tumor shows a higher incidence of loss of heterozygosity than pure-type seminoma.

Hum Pathol 2018 Sep 25. Epub 2018 Sep 25.

Department of Basic Pathology, National Defense Medical College, Tokorozawa, Saitama 359-8513, Japan.

Using analysis of allelic loss [loss of heterozygosity (LOH)], we previously reported a putative progression pathway from germ cell neoplasia in situ (GCNIS) to seminoma, and then to embryonal carcinoma in mixed-type testicular germ cell tumors. To identify the genetic backgrounds related to the progression of non-seminomatous germ cell tumor (NSGCT), patterns of LOH were studied in seminoma components in mixed tumors (18 cases), pure seminomas (20 cases), and co-existing GCNIS lesions. Each tumor was assessed for LOH at 22 polymorphic loci located on 12 chromosomal arms: 3q, 5q, 6p, 9p, 10q, 11p, 12p, 12q, 13q, 17p, 17q, and 18q. Read More

View Article
September 2018
1 Read

Laparoscopic Management of Chylous Leakage Using a Direct Lymph Node Injection with Methylene Blue as a Leakage Point Location Strategy in a Patient with Retroperitoneal Extragonadal Seminoma.

J Endourol Case Rep 2018 20;4(1):149-151. Epub 2018 Sep 20.

Department of Urology, Fundació Puigvert, Universitat Autònoma de Barcelona, Barcelona, Spain.

The first-line treatment in cases of chylous leakage is conservative, and operation should be considered only in patients who fail to respond to this treatment. The main clinical concern is the difficulty of intraoperative localization of the site of leakage that can affect surgical outcome. A 33-year-old man presented with a 4-month history of abdominal pain and weight loss. Read More

View Article
September 2018
1 Read

Testicular cancer guideline adherence and patterns of care in Germany: A nationwide survey.

Eur J Cancer Care (Engl) 2018 Sep 25:e12917. Epub 2018 Sep 25.

Department of Urology, University Hospital Dresden, Dresden, Germany.

Testicular cancer has excellent cure rates; however, poor guideline adherence can lead to inappropriate management, with a detrimental effect on outcomes. Therefore, we aimed to investigate the current patterns of care for testicular cancer patients and to evaluate guideline adherence. A 19-item survey was distributed among German urologists between September 2015 and September 2016. Read More

View Article
September 2018
8 Reads

Bilateral Malignant Seminoma With Ventricular Metastasis in a Bald Eagle ( Haliaeetus leucocephalus).

J Avian Med Surg 2018 Sep;32(3):240-245

A 30-year-old bald eagle ( Haliaeetus leucocephalus) was presented with a history of hyporexia and lethargy. Results of initial hematologic testing, biochemical analysis, and fecal examination were unremarkable, and clinical signs did not resolve with supportive care and management changes. Results of echocardiography, based on auscultation of a murmur, and coelomic endoscopy, based on the presence of a soft tissue opacity on radiographs, as well as an aspergillosis panel were largely unsuccessful in determining a definitive diagnosis. Read More

View Article
September 2018
1 Read
0.390 Impact Factor

SPIN1 is a proto-oncogene and SPIN3 is a tumor suppressor in human seminoma.

Oncotarget 2018 Aug 21;9(65):32466-32477. Epub 2018 Aug 21.

Institute of Human Genetics, Polish Academy of Sciences, Poznan, Poland.

SPIN1 is necessary for normal meiotic progression in mammals. It is overexpressed in human ovarian cancers and some cancer cell lines. Here, we examined the functional significance and regulation of SPIN1 and SPIN3 in the TCam-2 human seminoma cell line. Read More

View Article
August 2018
5 Reads

Testicular tumours discovered during infertility workup are predominantly benign and could initially be managed by sparing surgery.

J Surg Oncol 2018 Sep 9;118(4):630-635. Epub 2018 Sep 9.

Urology Department, Robert Picqué Hospital, Villenave d'Ornon, France.

Background And Objectives: To evaluate the pathological features and recurrence of incidental testis tumours treated by partial orchiectomy in a population of infertile men.

Methods: We retrospectively pooled, from four andrology referral centres, 32 patients diagnosed with testis mass during regular infertility workup. Patients included had an impaired sperm analysis and testis sparing surgery was performed to prevent secondary azoospermia or androgen therapy. Read More

View Article
September 2018
8 Reads

Thoracoscopic resection of a cystic seminoma of the mediastinum.

Asian J Endosc Surg 2018 Sep 5. Epub 2018 Sep 5.

Department of Pathology, Suwa Red Cross Hospital, Suwa, Japan.

Mediastinal seminoma is an uncommon tumor that accounts for 25% of primary mediastinal germ cell tumors, which in turn comprise fewer than 5% of all germ cell tumors. Although CT normally shows a solid, lobulated tumor, mediastinal cystic seminoma has rarely been described. Here, we report a 24-year-old man who presented with a mediastinal cystic tumor that was resected after an 18-month delay via video-assisted thoracoscopic surgery while in the supine position; the procedure involved lifting the chest wall with a subcutaneous Kirschner wire. Read More

View Article
September 2018
1 Read

Primary mediastinal seminoma.

J Thorac Dis 2018 Jul;10(7):4335-4341

Radiotherapy Department, Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland.

Background: The objective of this study was to evaluate the long term treatment results of patients with primary mediastinal seminoma.

Methods: Sixteen patients aged 21-46 diagnosed with primary mediastinal seminoma between 1983 and 2014. Mean size of the tumor was 65 cm. Read More

View Article
July 2018
8 Reads

Testis-sparing surgery: Experience in 13 patients with oncologic and functional outcomes.

Can Urol Assoc J 2018 08 30. Epub 2018 Aug 30.

Koc University, School of Medicine, Department of Urology, Istanbul.

Introduction: We present oncological and functional outcomes of patients who underwent testis-sparing surgery (TSS).

Methods: Overall, 13 patients were included. Mean patient age was 29. Read More

View Article
August 2018
2 Reads

Modern Management of Testicular Cancer.

Cancer Treat Res 2018 ;175:273-308

University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA, USA.

Testicular cancer is a rare urological malignancy with high cure rate. The development of highly effective systemic treatment regimens along with advances in surgical treatment of advanced disease has led to continued improvement in outcomes. Patients with testicular cancer who are treated following the treatment guideline mostly achieved high quality of life and long-term survival. Read More

View Article
January 2018
15 Reads

c-MET receptor as potential biomarker and target molecule for malignant testicular germ cell tumors.

Oncotarget 2018 Aug 7;9(61):31842-31860. Epub 2018 Aug 7.

Department of Anatomy, Histology, Forensic-Medicine and Orthopaedics, "Sapienza" University of Rome, Italy.

Type II testicular germ cell tumors (TGCTs) represent the most frequent malignancy in Caucasian males (20-40 years). Even if diagnosed with disseminated disease, >80% of patients are cured; however, a small percentage of cases progress and result in death. It is commonly accepted that these cancers arise from a disturbed testicular embryonic niche that leads to the block of gonocyte differentiation. Read More

View Article
August 2018
10 Reads

Metachronous Testicular Seminoma After Testicular Tumor.

Gulf J Oncolog 2018 May;1(27):78-81

Institute of Pathology, Faculty of Medicine, University Clinical Centre, Prishtina, Kosovo.

Testicular cancer represents approximately 1% of all cancers diagnosed in males. Testicular cancer is the most commonly diagnosed cancer in male adolescents and young adults between 15-35 years of age. Bilateral presentation is rare with a reported rate of 0. Read More

View Article
May 2018
1 Read

Positron-emission tomography imaging in urological oncology: Current aspects and developments.

Int J Urol 2018 Nov 13;25(11):912-921. Epub 2018 Aug 13.

Department of Urology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.

Positron-emission tomography/computed tomography combining both functional and morphological information has emerged as a powerful tool in oncological imaging within the past decades. The most commonly used radiotracer in oncology visualizing metabolic information is 2-[18F]fluoro-2-deoxy-d-glucose. However, the use of 2-[18F]fluoro-2-deoxy-d-glucose in urological oncology is challenging, as it is limited by physiological excretion through the urinary system. Read More

View Article
November 2018
5 Reads

A pooled analysis of published, basket trials in cancer medicine.

Eur J Cancer 2018 Sep 7;101:244-250. Epub 2018 Aug 7.

Division of Hematology and Medical Oncology, Knight Cancer Institute, USA; Department of Preventive Medicine and Public Health, USA; Center for Health Care Ethics, Oregon Health and Science University, Portland, OR, USA. Electronic address:

Background: There is widespread interest in cancer basket trials. However, to date, there has been no formal analysis of all published basket trials.

Methods: We performed a systematic review to identify all published basket trials in cancer medicine. Read More

View Article
September 2018
15 Reads

A case of spermatocytic seminoma in young individual.

Med J Armed Forces India 2018 Jul 16;74(3):276-279. Epub 2017 Feb 16.

Senior Adviser (Surgery & Oncosurgery), Command Hospital (Air Force), Bangalore, Karnataka 560007, India.

View Article
July 2018
4 Reads

Retroperitoneal extragonadal seminoma developed with acute lower inferior vena cava syndrome: A case report.

Urol Case Rep 2018 Sep 5;20:72-74. Epub 2018 Jul 5.

Division of Urology, Department of Regenerative and Transplant Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.

View Article
September 2018
4 Reads

Surgical resection of a giant polycystic seminoma of the mediastinum.

J Thorac Dis 2018 Jun;10(6):E438-E441

Division of Thoracic and Cardiovascular Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.

View Article
June 2018
1 Read

Protein expression of the transcription factors DMRT1, TCLF5, and OCT4 in selected germ cell neoplasms of the testis.

Hum Pathol 2018 Dec 29;82:68-75. Epub 2018 Jul 29.

Department of Pathology, Indiana University School of Medicine, Indianapolis, IN 46202, USA; Department of Urology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

In the present study, we investigated protein expression of the transcription factors mammalian doublesex and mab-3 related transcription factor 1 (DMRT1), basic helix-loop-helix transcription factor-like 5 (TCLF5), and octamer-binding transcription factor 4 (OCT4) in normal human spermatogenesis, testicular mixed germ cell-sex cord stromal tumor (MGC-SCST), spermatocytic tumor, and seminoma. In normal human spermatogenesis, DMRT1 is expressed in the nuclei of spermatogonia but not in those of more mature germ cells. By way of contrast, TCLF5 is expressed in the nuclei of some clusters of primary spermatocytes that have entered meiosis 1, in secondary spermatocytes, and in round (early) spermatids in the seminiferous tubules of adults during the reproductive years. Read More

View Article
December 2018
3 Reads

[A Case of Giant Testicular Tumor with Pelvic and Inguinal Lymph Nodes Metastasis].

Hinyokika Kiyo 2018 Jun;64(6):277-281

The Department of Urology, Wakayama Medical University.

A 51-year-old man visited our hospital since he had noticed remarkable increase in size of left scrotal contents. Computed tomography revealed left testicular swelling, retroperitoneal, pelvic and left inguinal lymph nodes. Serum testicular tumor markers (α fetoprotein, β-human chorionic gonadotropin, lactate dehydrogenase) were elevated. Read More

View Article
June 2018
8 Reads

[Myocardial infarction in a young patient with seminoma during chemotherapy with cisplatinum, etoposide, and bleomycin].

Aktuelle Urol 2018 Jul 31. Epub 2018 Jul 31.

Urologie, Asklepios Klinik Altona, Hamburg.

Introduction:  More than 90 % of all patients with testicular germ cell tumours can be cured effectively. The mainstay of treatment is chemotherapy with cisplatin, etoposide and bleomycin (PEB). This regimen is usually well tolerated and does not lead to serious adverse events. Read More

View Article
July 2018
3 Reads

Testicular cavernous hemangioma associated with testicular torsion - case report and review of literature.

Int J Surg Case Rep 2018 27;49:247-250. Epub 2018 Jun 27.

Department of Pediatric and Adolescent Surgery, General Hospital, Klagenfurt, Austria. Electronic address:

Introduction: Testicular neoplasms that are derived from connective tissue, blood vessels and musculature are uncommon and intra-testicular tumors of vascular origin are extremely rare; both are benign in nature. Testicular hemangioma is exceedingly rare and typically occurs in patients younger than 20 years, the age in which a primary germ cell tumor of the testis may present, necessitating a radical approach to management with orchidectomy, although potential conservative focal partial surgical excision is desirable. Hemangiomas of the testis have a similar sonographic and magnetic resonance imaging appearance to that of malignant tumors of the testis, especially seminoma. Read More

View Article
June 2018
3 Reads

[Treatment of 21 cases of chronic radiation intestinal injury by staging ileostomy and closure operation].

Zhonghua Wei Chang Wai Ke Za Zhi 2018 Jul;21(7):772-778

Department of General Surgery, Jinling Hospital, Nanjing 210002, China.

Objective: To summarize the application of staged ileostomy and closure operation combined with nutritional support therapy in the treatment of chronic radiation intestinal injury(CRII).

Methods: Clinical data of patients with definite radiation history and pathological diagnosis of CRII receiving treatment at Department of General Surgery, Jinling Hospital from January 2012 to December 2016 were retrospectively analyzed. Patients who were diagnosed with tumor recurrence during operation or by postoperative pathology were excluded. Read More

View Article
July 2018
5 Reads

Baseline characteristics and patterns of care in testicular cancer patients: first data from the Swiss Austrian German Testicular Cancer Cohort Study (SAG TCCS).

Swiss Med Wkly 2018;148:w14640. Epub 2018 Jul 24.

University of Bern, Switzerland.

Background: The majority of germ cell tumour (GCT) patients can be cured by orchiectomy followed by active surveillance or subsequent systemic and/or local treatments. There are various guidelines for a structured follow-up including radiographic and clinical examinations.

Objective: The Swiss Austrian German Testicular Cancer Cohort Study (SAG TCCS) prospectively evaluates follow-up, indicator of relapse and late toxicities. Read More

View Article
July 2018
13 Reads