6,159 results match your criteria Seminoma


Solid and Hematologic Neoplasms After Testicular Cancer: A US Population-Based Study of 24 900 Survivors.

JNCI Cancer Spectr 2020 Jun 17;4(3):pkaa017. Epub 2020 Mar 17.

University of Rochester, School of Medicine and Dentistry, Rochester, NY, USA.

Background: No large US population-based study focusing on recent decades, to our knowledge, has comprehensively examined risks of second malignant solid and hematological neoplasms (solid-SMN and heme-SMN) after testicular cancer (TC), taking into account initial therapy and histological type.

Methods: Standardized incidence ratios (SIR) vs the general population and 95% confidence intervals (CI) for solid-SMN and heme-SMN were calculated for 24 900 TC survivors (TCS) reported to the National Cancer Institute's Surveillance, Epidemiology, and End Results registries (1973-2014). All statistical tests were two-sided. Read More

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http://dx.doi.org/10.1093/jncics/pkaa017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236780PMC

Multiparametric ultrasonographic analysis of testicular tumors: a single-center experience in a collective of 49 patients.

Scand J Urol 2020 May 25:1-7. Epub 2020 May 25.

Department of Radiology, Ludwig-Maximilians-University Munich - Grosshadern Campus, Munich, Germany.

The aim of the present retrospective single-center study is to evaluate the diagnostic performance of multiparametric ultrasonography for characterizing testicular tumors. Forty-nine patients with testicular tumors, 36 of malignant vs 13 of benign entity, were included in this retrospective single-center study on whom multiparametric sonography, encompassing native B-mode, Color Doppler, contrast-enhanced ultrasound (CEUS) and elastography, was performed between 2011-2018. In 48 of 49 patients, findings from multiparametric analysis were correlated with histopathological results. Read More

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http://dx.doi.org/10.1080/21681805.2020.1765863DOI Listing

Outcomes following surgery for primary mediastinal nonseminomatous germ cell tumors in the cisplatin era.

J Thorac Cardiovasc Surg 2020 Apr 22. Epub 2020 Apr 22.

Division of Medical Oncology, Department of Medicine, Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, Ind.

Objective: Treatment of primary mediastinal nonseminomatous germ cell tumors involves cisplatin-based chemotherapy followed by surgery to remove residual disease. We undertook a study to determine short and long-term outcomes.

Methods: A retrospective analysis of patients with primary mediastinal nonseminomatous germ cell tumors who underwent surgery at our institution from 1982 to 2017 was performed. Read More

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http://dx.doi.org/10.1016/j.jtcvs.2020.01.118DOI Listing

Fine needle aspiration of mediastinal germ cell tumors.

Semin Diagn Pathol 2020 May 13. Epub 2020 May 13.

Department of Pathology and Laboratory Medicine University of Florida-Jacksonville, Jacksonville, FL.

Germ cell tumors in the mediastinum are rare and often occur in young patients but may occur in older patients. Seminoma, embryonal carcinoma, yolk sac tumor, choriocarcinoma and teratoma have distinct morphologic features with high grade nuclei. They are the primary diagnostic consideration in young males but may be lower on the list in older patients, where they may be misdiagnosed as carcinomas. Read More

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http://dx.doi.org/10.1053/j.semdp.2020.04.008DOI Listing

Snail factors in testicular germ cell tumours and their regulation by the BMP4 signalling pathway.

Andrology 2020 May 22. Epub 2020 May 22.

Centre for Reproductive Health, Hudson Institute of Medical Research, Clayton, Victoria, Australia.

Background: Snail transcription factors mediate key cellular transitions in many developmental processes, including spermatogenesis, and their production can be regulated by TGF-β superfamily signalling. SNAI1 and SNAI2 support many cancers of epithelial origin. Their functional relevance and potential regulation by TGF-β superfamily ligands in germ cell neoplasia are unknown. Read More

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http://dx.doi.org/10.1111/andr.12823DOI Listing

Testicular cancer in Hispanics: incidence of subtypes over time according to neighborhood sociodemographic factors in California.

Cancer Causes Control 2020 May 21. Epub 2020 May 21.

Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA.

Purpose: Hispanic men in the USA experience the second-highest incidence rate of testicular germ cell tumors (TGCTs), behind non-Hispanic (NH) White men, and have experienced steep increases in TGCT in recent decades. It is unknown whether increases in incidence differ according to neighborhood sociodemographic factors.

Methods: We conducted a population-based study of n = 3759 Hispanic and n = 8469 NH White men (n = 12,228 total) diagnosed with TGCT in California during the three most recent pericensal periods. Read More

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http://dx.doi.org/10.1007/s10552-020-01311-2DOI Listing

Targeting EpCAM by a Bispecific Trifunctional Antibody Exerts Profound Cytotoxic Efficacy in Germ Cell Tumor Cell Lines.

Cancers (Basel) 2020 May 19;12(5). Epub 2020 May 19.

Department of Pediatric Hematology and Oncology, University Hospital Bonn, University of Bonn, 53127 Bonn, Germany.

Outcome in high-risk patients with refractory or relapsed germ cell tumours (GCT) remains poor. Novel strategies enhancing therapeutic efficacy whilst limiting therapeutic burden are warranted, yet immunotherapy approaches geared towards activating endogenous antitumor responses have not been successful thus far. Redirection of cytotoxic effector cells by bispecific antibodies represents a promising approach in this setting. Read More

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http://dx.doi.org/10.3390/cancers12051279DOI Listing

Mediastinal seminoma mimicking invasive thymoma on F-FDG PET/CT.

Authors:
Huipan Liu Yue Chen

J Nucl Cardiol 2020 May 6. Epub 2020 May 6.

Department of Nuclear Medicine, The Affiliated Hospital of Southwest Medical University/Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, No. 25 TaiPing St., Jiangyang District, Luzhou, 646000, Sichuan, People's Republic of China.

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http://dx.doi.org/10.1007/s12350-020-02127-yDOI Listing

Testicular Seminoma Presenting with Bilateral Blindness: Looking Beyond the Eye.

Cureus 2020 Apr 4;12(4):e7534. Epub 2020 Apr 4.

Pulmonary and Critical Care, Truman Medical Center, University of Missouri-Kansas City School of Medicine, Kansas City, USA.

Cancer-associated retinopathy (CAR) is a rare cause of vision loss that was first reported in 1976. It is reported that the retinopathy associated with cancer occurs due to antibodies against the tumor antigens that cross-react with retinal cell layers. We present the case of a young male who came to the emergency department with sudden onset of bilateral vision loss. Read More

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http://dx.doi.org/10.7759/cureus.7534DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198102PMC

Human chorionic gonadotropin-positive seminoma patients: A registry compiled by the global germ cell tumor collaborative group (G3).

Eur J Cancer 2020 Jun 29;132:127-135. Epub 2020 Apr 29.

Department of Oncology, Hematology and Bone Marrow Transplantation with Division of Pneumology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Background: The prognostic role of human chorionic gonadotropin (hCG) and lactate dehydrogenase (LDH) serum levels in seminoma patients remains uncertain. This observational study evaluates the prognostic impact of tumour marker levels, and other clinicopathological findings, in hCG-positive seminoma patients.

Methods: Seminoma patients with serum hCG levels above normal at first diagnosis were eligible for recruitment. Read More

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http://dx.doi.org/10.1016/j.ejca.2020.03.022DOI Listing

CD34 Positive Tubular Basement Membrane in Testicular Germ Cell Tumors: A Potential Staging Pitfall.

Histopathology 2020 May 1. Epub 2020 May 1.

Department of Pathology, VCU School of Medicine, Richmond, VA, 23226, USA.

Staging of testicular germ cell tumours is essential for treatment planning and prognosis[1]. Lymphovascular invasion (LVI) is one key parameter that establishes pT2 in pathologic staging and Prognostic Stage Group IB for both seminoma and mixed germ cell tumours otherwise limited to the testis [1]. While current practice guidelines [2] consider surveillance preferred for Stage I pure seminomas given the high rate of cure by orchiectomy alone, single agent carboplatin or radiotherapy remain considerations. Read More

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http://dx.doi.org/10.1111/his.14131DOI Listing

HMGA1-Regulating microRNAs Let-7a and miR-26a are Downregulated in Human Seminomas.

Int J Mol Sci 2020 Apr 24;21(8). Epub 2020 Apr 24.

Department of Psychology, University of Campania "L. Vanvitelli", 81100 Caserta, Italy.

Background: Recent studies have underlined HMGA protein's key role in the onset of testicular germ cell tumors, where HMGA1 is differently expressed with respect to the state of differentiation, suggesting its fine regulation as master regulator in testicular tumorigenesis. Several studies have highlighted that the transcript is strictly regulated by a set of inhibitory microRNAs. Thus, the aim of this study is to test whether HMGA1 overexpression in human seminomas may be induced by the deregulation of miR-26a and Let-7a-two -targeting microRNAs. Read More

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http://dx.doi.org/10.3390/ijms21083014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7215726PMC

Supraclavicular left neck mass: an unusual presentation of metastatic testicular cancer in two older men.

BMJ Case Rep 2020 Apr 22;13(4). Epub 2020 Apr 22.

Department of Radiology, Eastbourne District General Hospital, Brighton, UK.

Two male patients, aged 55 and 75 years, were referred to the ENT and haematology team respectively, with an asymptomatic left supraclavicular neck mass. Investigations revealed metastatic primary testicular seminoma. CT contrast study of the thorax, abdomen and pelvis demonstrated an additional left para-aortic nodal mass in both cases. Read More

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http://dx.doi.org/10.1136/bcr-2019-233368DOI Listing

Testicular Carcinoid Tumor in a Patient With Contralateral Classic Seminoma.

Urology 2020 Apr 16. Epub 2020 Apr 16.

Institute of Urology, University of Southern California, Los Angeles, CA. Electronic address:

Testicular neuroendocrine tumors, commonly called carcinoid, are extremely rare and account for less than 1% of all testicular neoplasms. The most common type is primary carcinoid followed by testicular metastasis from another primary and rarely carcinoid within a testicular teratoma. To date, less than 25 cases of carcinoid associated teratomas have been reported in the literature. Read More

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http://dx.doi.org/10.1016/j.urology.2020.04.011DOI Listing
April 2020
2.188 Impact Factor

Prognostic Potential of the Expression of Podoplanin (D2-40) Within Cells of Squamous Cell Carcinoma of the Larynx and Hypopharynx.

World J Oncol 2020 Apr 29;11(2):65-71. Epub 2020 Mar 29.

Department of Oto-Rhino-Laryngology, Plastic, Aesthetic and Reconstructive Head and Neck Surgery, University Hospital of Wuerzburg, Josef-Schneider-Str. 2, D-97080 Wuerzburg, Germany.

Background: Podoplanin (D2-20) stains immunohistochemically lymphatic vessels, regular mesothelium and tumor cells of different tumors, e.g. malignant mesothelioma or seminoma. Read More

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http://dx.doi.org/10.14740/wjon1259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141162PMC

The Clinical Significance of Seminoma Component in Testicular Mixed Germ Cell Tumour.

Urol Int 2020 Apr 2:1-8. Epub 2020 Apr 2.

Department of Urology, University of Health Sciences, Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey.

Background: The aim of this study was to examine clinical/pathological characteristics, prognosis and tendency to metastasis of mixed germ cell tumours (MGCTs) that contain a seminoma component.

Methods: A total of 111 MGCT cases between 2008 and 2018 were retrospectively enrolled. The patients were divided into 2 groups according to the absence (group 1) or presence (group 2) of seminoma component in MGCTs. Read More

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http://dx.doi.org/10.1159/000506780DOI Listing

Non-Coding microRNAs as Novel Potential Tumor Markers in Testicular Cancer.

Cancers (Basel) 2020 Mar 22;12(3). Epub 2020 Mar 22.

Research Unit of Non-Coding RNAs and Genome Editing in Cancers, Medical University of Graz, 8010 Graz, Austria.

Testicular cancer is an important disease with increasing incidence and a high burden of morbidity and mortality in young men worldwide. Histological examination of the testicular tissue after orchiectomy plays an important role alongside patient history, imaging, clinical presentation and laboratory parameters. Surgical procedures and chemotherapeutic treatment provide a high chance of cure in early stages, though some patients in advanced stages belonging to a poor risk group experience cancer-related death. Read More

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http://dx.doi.org/10.3390/cancers12030749DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140096PMC

[Clinicopathologic features of testicular seminoma with syncytiotrophoblastic cells: Analysis of 3 cases and review of the literature].

Zhonghua Nan Ke Xue 2019 Jul;25(7):642-646

Department of Pathology, General Hospital of Eastern Theater Command, Nanjing, Jiangsu 210002, China.

Objective: To investigate the clinical and histopathologic features of testicular seminoma with syncytoplasmic trophoblastic components.

Methods: Using light microscopic staining, we analyzed the clinical and histopathologic characteristics, diagnosis, differential diagnosis and prognosis of 3 cases of testicular seminoma with syncytoplasmic trophoblastic components, and reviewed the relevant literature.

Results: All the 3 cases were typical seminoma with syncytiotrophoblastic giant cells. Read More

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Identification of sumoylated targets in proliferating mouse spermatogonia and human testicular seminomas.

Asian J Androl 2020 Mar 27. Epub 2020 Mar 27.

Department of Biology, Stern College, Yeshiva University, New York, NY 10016, USA.

Spermatogenesis is regulated by a complex network of posttranslation modifications. Sumoylation (a modification by small ubiquitin-like modifiers, or SUMO proteins) was identified as an important cellular event in different cell types. SUMO proteins are highly expressed in the testis, and their role during spermatogenesis has begun to be elucidated. Read More

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http://dx.doi.org/10.4103/aja.aja_11_20DOI Listing

Paraneoplastic tumefactive demyelination in a 47-year-old man with underlying seminoma.

Mult Scler Relat Disord 2020 Mar 16;42:102060. Epub 2020 Mar 16.

Neurology department, GZA Sint-Augustinus Hospital, Oosterveldlaan 24, 2610 Antwerp, Belgium.

Background: Tumefactive demyelination presents as an aggressive, fast progressive focal demyelinating lesion in the central nervous system, with often devastating clinical outcome if not acutely treated. Correct and early treatment is threatened by its real diagnostic challenge.

Case Report: We describe a 47-year-old man with tumefactive demyelination and testicular seminoma. Read More

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http://dx.doi.org/10.1016/j.msard.2020.102060DOI Listing

Management of Giant Seminoma in an Undescended Testis: a Case Report.

Indian J Surg Oncol 2020 Mar 17;11(1):159-161. Epub 2019 Aug 17.

SMS Medical College & Attached Hospitals, Jaipur, Rajasthan India.

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http://dx.doi.org/10.1007/s13193-019-00967-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7064672PMC

Report From the International Society of Urological Pathology (ISUP) Consultation Conference on Molecular Pathology of Urogenital Cancers: IV: Current and Future Utilization of Molecular-Genetic Tests for Testicular Germ Cell Tumors.

Am J Surg Pathol 2020 Mar 20. Epub 2020 Mar 20.

Pathology, Indiana University School of Medicine, Indianapolis, IN.

The International Society of Urological Pathology (ISUP) organized a Consultation Conference in March 2019 dealing with applications of molecular pathology in Urogenital Pathology, including testicular tumors (with a focus on germ cell tumors [GCTs]), preceded by a survey among its members to get insight into current practices in testicular germ cell tumor (TGCT) diagnostics and adoption of the ISUP immunohistochemical guidelines published in 2014. On the basis of the premeeting survey, the most commonly used immunomarker panel includes OCT3/4, placental alkaline phosphate, D2-40, SALL4, CD117, and CD30 for GCTs and the documentation of germ cell neoplasia in situ (GCNIS). Molecular testing, specifically 12p copy gain, is informative to distinguish non-GCNIS versus GCNIS related GCTs, and establishing germ cell origin of tumors both in the context of primary and metastatic lesions. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001465DOI Listing
March 2020
5.145 Impact Factor

Comparing genome-scale DNA methylation and CNV marks between adult human cultured ITGA6+ testicular cells and seminomas to assess in vitro genomic stability.

PLoS One 2020 16;15(3):e0230253. Epub 2020 Mar 16.

Center for Reproductive Medicine, Research Institute Reproduction and Development, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

Autologous transplantation of spermatogonial stem cells is a promising new avenue to restore fertility in infertile recipients. Expansion of the initial spermatogonial stem cell pool through cell culturing is a necessary step to obtain enough cells for effective repopulation of the testis after transplantation. Since in vitro propagation can lead to (epi-)genetic mutations and possibly malignant transformation of the starting cell population, we set out to investigate genome-wide DNA methylation status in uncultured and cultured primary testicular ITGA6+ sorted cells and compare them with germ cell tumor samples of the seminoma subtype. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0230253PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7075560PMC

Expression of claudin-11 in canine prepubertal testes, and in canine adult testes showing normal spermatogenesis, impaired spermatogenesis, or testicular neoplasia.

Theriogenology 2020 May 5;148:122-131. Epub 2020 Mar 5.

Institute for Anatomy, University of Veterinary Medicine Hannover, Foundation, Bischofsholer Damm 15, 30173, Hannover, Germany. Electronic address:

The blood-testis barrier (BTB) consists of different cell-to-cell connections, including tight junction proteins like claudin-11 (CLDN11). For dogs, only limited data is published dealing with these proteins in general. Therefore, their physiological relevance, their postnatal expression, and their distribution pattern in pathological conditions, e. Read More

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http://dx.doi.org/10.1016/j.theriogenology.2020.03.001DOI Listing

Management of residual disease after chemotherapy in germ cell tumors.

Curr Opin Oncol 2020 May;32(3):250-255

Division of Hematology & Medical Oncology - Melvin and Bren Simon Cancer Center, Indiana University School of Medicine, Indianapolis, Indiana, USA.

Purpose Of Review: Although testicular cancer remains a highly curable malignancy, challenges and uncertainty still remain in certain aspects of management. Residual disease after chemotherapy in patients with germ cell tumors (GCT) remains one of these challenges. We aim to highlight the recent literature on the management of residual disease after chemotherapy in GCT and the emerging innovations that may provide further guidance into this area. Read More

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http://dx.doi.org/10.1097/CCO.0000000000000619DOI Listing

Evaluation of nuclear NF-κB, transglutaminase2, and ERCC1 as predictors of platinum resistance in testicular tumors.

Int Braz J Urol 2020 May-Jun;46(3):353-362

Programa de Pós-Graduação em Medicina e Ciências da Saúde, Escola de Medicina e Laboratório de Farmacologia Aplicada, Escola de Ciências da Saúde, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brasil.

Purpose: Testicular germ cells tumor (TGCT) are associated with a high cure rate and are treated with platinum-based chemotherapy. However, a group of testicular cancer patients may have a very unfavorable evolution and insensitivity to the main therapeutic agent chemotherapy (CT) cisplatin. The aim of this study was to evaluate the risk of recurrence and overall survival related to the expression of nuclear factor kappa-B (NF-κB), transglutaminase 2 (TG2) and excision repair cross-complementation group 1 (ERCC1) in patients with TGCT treated with platinum combinations. Read More

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http://dx.doi.org/10.1590/S1677-5538.IBJU.2019.0011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7088506PMC
January 2019

[Late Recurrence of Seminoma Diagnosed by Endoscopic Ultrasound-Guided Fine Needle Aspiration in a Retroperitoneal Lymph Node].

Hinyokika Kiyo 2020 Feb;66(2):53-57

The Department of Urology, Osaka Rosai Hospital.

The patient was a 43-year-old man. At 30 years of age, he underwent high-inguinal orchiectomy for a right testicular tumor and was diagnosed with seminoma pT1N0M0. The patient had been followed without additional treatment and had dropped out 7 years after surgery. Read More

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http://dx.doi.org/10.14989/ActaUrolJap_66_2_53DOI Listing
February 2020

Application of miRNAs in the diagnosis and monitoring of testicular germ cell tumours.

Nat Rev Urol 2020 04 10;17(4):201-213. Epub 2020 Mar 10.

Department of Urology, Hodentumorzentrum Hamburg, Asklepios Klinik Altona, Hamburg, Germany.

Testicular germ cell tumours (TGCTs) are the most frequent cancer type in young men and originate from the common precursor germ cell neoplasia in situ (GCNIS). For decades, clinical management of patients with TGCT has relied on classic serum tumour markers: α-fetoprotein, human chorionic gonadotropin subunit-β and lactate dehydrogenase. In the past 10 years, microRNAs have been shown to outperform classic serum tumour markers in the diagnosis of primary tumours and in follow-up monitoring and prediction of relapse. Read More

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http://dx.doi.org/10.1038/s41585-020-0296-xDOI Listing

Characterization and distribution of sialic acids in human testicular seminoma.

Acta Histochem 2020 Apr 3;122(3):151532. Epub 2020 Mar 3.

Department of Biosciences and Territory, University of Molise, Contrada Fonte Lappone, 86090 Pesche (Isernia), Italy. Electronic address:

Aberrant content of sialic acids (Sias) has been observed in various human cancer types in different organs. Sias have been implicated in cancerous transformation, invasiveness and metastasis, and in the escaping of cancer cells from immune surveillance. Indeed, Sias are commonly regarded as important biomarkers to distinguish cancer cells from their healthy counterparts. Read More

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http://dx.doi.org/10.1016/j.acthis.2020.151532DOI Listing

The utility of De Ritis Ratio in predicting prognosis in testicular cancer.

Aktuelle Urol 2020 Mar 5. Epub 2020 Mar 5.

Yuksek Ihtisas Training and Research Hospital, Urology, Ankara.

Objective:  We aimed to investigate the possible association between testicular cancer prognosis and De Ritis ratio (AST/ALT).

Methods:  The medical records of all patients who underwent radical inguinal orchiectomy at a single tertiary in Istanbul, Turkey between 2006 and 2017 were retrospectively analyzed. Investigated parameters included patients' demographics, complete blood count and blood biochemistry results, pathology results, treatment schemes, imaging results, and survival. Read More

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http://dx.doi.org/10.1055/a-1117-2776DOI Listing

Significance of 18F-FDG PET/CT in Characterization of Equivocal Lesions in High-Risk Testicular Carcinoma in Restaging Setting.

Asian Pac J Cancer Prev 2020 Feb 1;21(2):511-515. Epub 2020 Feb 1.

Department of Nuclear Medicine, Kuwait Cancer Control Center, Ministry of Health, Kuwait.

Objectives: The present study aims to evaluate the role of Positron emission tomography (PET) -computed tomography (CT) with 18F-fluorodeoxyglucose (18F-FDG) in the restaging of high-risk testicular cancer.

Methods: Forty-five patients (mean age of 38.1±11. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.2.511DOI Listing
February 2020
1.500 Impact Factor

Seminoma In A Young Phenotypic Female With Turner Syndrome 45,XO/46,XY Mosaicism: A Case Report With Review Of The Literature.

Urology 2020 May 10;139:168-170. Epub 2020 Feb 10.

University of Utah, Division of Pediatric Urology, Salt Lake City, UT.

Turner syndrome is a chromosomal disorder that occurs in an estimated 1 in 2500 female live births. It is estimated that 6%-12% of all Turner syndrome patients will be a mosaic with Y-chromosomal elements putting them at risk for gonadoblastoma and subsequent dysgerminoma. While 30%-50% of this population demonstrate gonadoblastoma, we only found 23 reported cases of dysgerminoma in the literature, and no reported cases of seminoma. Read More

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http://dx.doi.org/10.1016/j.urology.2020.01.031DOI Listing

Systemic therapy for primary and extragonadal germ cell tumors: prognosis and nuances of treatment.

Transl Androl Urol 2020 Jan;9(Suppl 1):S56-S65

Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Testicular germ cell tumors are the most common solid tumors in young men. These cancers represent a success story of modern medicine in our ability to cure young patients and offer decades of life, with a 5-year survival rate of approximately 95%. This review outlines the staging and risk classification of testicular cancers, and reviews the current state of knowledge and standard of care for the systemic treatment of testicular germ cell tumors with chemotherapy, focusing on the relevant clinical data supporting each treatment regimen. Read More

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http://dx.doi.org/10.21037/tau.2019.09.11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6995840PMC
January 2020

Contemporary management of early stage testicular seminoma.

Transl Androl Urol 2020 Jan;9(Suppl 1):S36-S44

Department of Radiation Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.

Therapy for early stage testicular seminoma has changed radically over the past several decades. Given high cure rates and clinical trials supporting less active therapy in most cases, close observation after radical orchiectomy is now considered standard of care for clinical stage (CS) IA/IB seminoma, with either radiation therapy (RT) or chemotherapy salvage options possible. For CS IIA/IIB seminoma characterized by non-bulky retroperitoneal lymph node involvement (≤5 cm in greatest dimension), RT or combination chemotherapy are the standard of care. Read More

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http://dx.doi.org/10.21037/tau.2019.09.32DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6995845PMC
January 2020

Primary Mediastinal Seminoma Achieved by Transbronchial Mediastinal Cryobiopsy.

Respiration 2020 12;99(5):426-430. Epub 2020 Feb 12.

Department of Respiratory Disease, Xinqiao Hospital, Third Military Medical University, Chongqing, China,

Mediastinal biopsy is essential for the clinical diagnosis of mediastinal disease. Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a well-established approach for obtaining diagnostic samples from mediastinal masses or enlarged lymph nodes which is proven to be minimally invasive and effective. However, the insufficiency of intact samples acquired might restrict the diagnostic efficacy of EBUS-TBNA for mediastinal lesions such as rare malignancy and granulomatous disorder. Read More

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http://dx.doi.org/10.1159/000505936DOI Listing
February 2020
2.593 Impact Factor

Primary retroperitoneal germ cell tumor in an adult female: A case report.

Medicine (Baltimore) 2020 Feb;99(7):e19170

Department of Radiology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.

Rationale: Primary retroperitoneal germ cell tumors are uncommon and especially rare in female patients. However, this type should be included in the differential diagnosis of retroperitoneal tumors that may metastasize from the gonads and be a primary tumor.

Patient Concerns: An abdominal mass was detected in a 38-year-old woman during physical examination, which was accompanied by left renal obstructive hydrops. Read More

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http://dx.doi.org/10.1097/MD.0000000000019170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7035024PMC
February 2020

Ominous Occurrence of Spinal Intradural Primary Malignant Peripheral Nerve Sheath Tumor Four Decades following Radiation Therapy for Testicular Seminoma.

Case Rep Neurol Med 2020 27;2020:1792582. Epub 2020 Jan 27.

Department of Neurological Surgery, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.

Primary intradural malignant peripheral nerve sheath tumor (MPNST) is an extremely rare diagnosis and is associated with an extremely poor prognosis. A 77-year-old man diagnosed with an intradural MPNST, more than 40 years after radiation for a testicular seminoma, is reported. Intradural MPNSTs of the spine outside the setting of neurofibromatosis is extremely rare and can masquerade as common benign nerve sheath tumors, on imaging. Read More

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http://dx.doi.org/10.1155/2020/1792582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7007932PMC
January 2020

Prognostic value of primary tumor surgery in seminoma patients with distant metastasis at diagnosis: a population-based study.

Asian J Androl 2020 Feb 4. Epub 2020 Feb 4.

Department of Urology, Fudan University Shanghai Cancer Center, Shanghai 200032, China.

The aims of this study were to determine the prognostic value of primary tumor surgery and identify optimal candidates for such surgery among patients with seminoma and distant metastasis at diagnosis. We identified 521 patients with seminoma and distant metastasis at diagnosis between 2004 and 2014 from the Surveillance, Epidemiology, and End Results database. Among these patients, 434 had undergone surgery, whereas 87 had not. Read More

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http://dx.doi.org/10.4103/aja.aja_140_19DOI Listing
February 2020
2.530 Impact Factor

Editorial Comment: New Insights on the Mechanisms Affecting Fertility in Men with Non-Seminoma Testicular Cancer before Cancer Therapy.

Int Braz J Urol 2020 Mar-Apr;46(2):277-278

Chefe do Departamento de Oncologia Cirúrgica, Beneficência Portuguesa de São Paulo, São Paulo, SP, Brasil.

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http://dx.doi.org/10.1590/S1677-5538.IBJU.2020.02.07DOI Listing

Trends in incidence, mortality and survival of testicular cancer patients in Belarus.

Cent European J Urol 2019 30;72(4):357-368. Epub 2019 Dec 30.

Department of Urology, N.N. Alexandrov National Research Cancer Center, Minsk, Belarus.

Introduction: The objective of this study was to assess recent trends in incidence, mortality and relative survival (RS) in testicular cancer (TC) patients in Belarus and to provide international comparisons of our figures.

Material And Methods: We surveyed the Belarusian Cancer Registry for all male cases diagnosed with International Classification of Diseases for Oncology, third edition (ICD-O-3) topography code C62 between 1990 and 2015. Trends for incidence and mortality rates per 100,000 of the world standard population and annual percentage changes (APCs) were calculated. Read More

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http://dx.doi.org/10.5173/ceju.2019.0073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6979549PMC
December 2019

[Intimal sarcoma of pulmonary arteries].

Orv Hetil 2020 Feb;161(6):232-236

Pathologiai Intézet, Szegedi Tudományegyetem, Általános Orvostudományi Kar Szeged, Állomás u. 1., 6725.

Pulmonary arterial intimal sarcoma is a rare tumour with high mortality. Due to its localisation, the symptoms can mimic pulmonary thromboembolism and pneumonia, therefore assessing the diagnosis and choosing the adequate therapy is never easy. Its therapy mainly consists of surgery combined with radiochemotherapy. Read More

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http://dx.doi.org/10.1556/650.2020.31642DOI Listing
February 2020

Long-term outcomes with intensive induction chemotherapy (carboplatin, bleomycin, vincristine and cisplatin/bleomycin, etoposide and cisplatin) and standard bleomycin, etoposide and cisplatin in poor prognosis germ cell tumours: A randomised phase II trial (ISRCTN53643604).

Eur J Cancer 2020 Mar 31;127:139-149. Epub 2020 Jan 31.

The Institute of Cancer Research and the Royal Marsden NHS Foundation Trust, Downs Road, Sutton, SM2 5PT, UK.

Background: Up to 50% of men with poor prognosis, non-seminoma germ cell tumours (GCTs) die with standard BEP (bleomycin, etoposide and cisplatin) chemotherapy. An intensive regimen, CBOP/BEP (carboplatin, bleomycin, vincristine and cisplatin/BEP), met response targets in a randomised, phase II trial (74% complete response or partial response marker negative, 90% confidence interval (CI) 61%-85%).

Aim: To assess long-term outcomes and late toxicity associated with CBOP/BEP. Read More

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http://dx.doi.org/10.1016/j.ejca.2019.12.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7045084PMC

Prognosis of Patients With Testicular Carcinoma Is Dependent on Metastatic Site.

Front Oncol 2019 10;9:1495. Epub 2020 Jan 10.

Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China.

Existing data on the association of metastatic sites and prognosis of patients with metastatic testicular malignancy are limited. In this study, the association of survival outcome and the prognostic value of different metastatic sites in patients with metastatic testicular cancer was investigated. A dataset from the Surveillance, Epidemiology and End Results (SEER) survey was selected for a retrospective metastatic testicular cancer cohort study. Read More

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http://dx.doi.org/10.3389/fonc.2019.01495DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966605PMC
January 2020

Coronary vasospasm induced by cisplatin for seminoma.

Clin Case Rep 2020 Jan 19;8(1):190-193. Epub 2019 Dec 19.

Division of Cardiovascular Medicine Saitama Medical Center Jichi Medical University Saitama Japan.

Vascular toxicity is one of serious complications following cisplatin-based chemotherapy. This case suggests that cisplatin has a potential risk of delayed occurrence of vasospastic angina. It is important to perform careful history taking including discontinued drugs for differential diagnosis of chest pain. Read More

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http://dx.doi.org/10.1002/ccr3.2601DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982474PMC
January 2020

A Rare Case of Intracranial Nongerminomatous Germ Cell Tumor in a 21-Year-Old Romanian Male.

Case Rep Oncol Med 2020 3;2020:3787250. Epub 2020 Jan 3.

Department of Neurological Critical Care Medicine, AtlantiCare Regional Medical Center, 1925 Pacific Avenue, Atlantic City, NJ, USA.

Extragonadal germ cell tumors are a rare entity that is more prevalent in infants and young children, with preference to midline structures. The category of intracranial germ cell tumors is divided into pure germ cell tumors (GCTs) versus nongerminomatous germ cell tumors (NGGCTs). They are usually present in the second decade of life with a male preponderance. Read More

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http://dx.doi.org/10.1155/2020/3787250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6964716PMC
January 2020

Role of primary retroperitoneal lymph node dissection in stage I and low-volume metastatic germ cell tumors.

Curr Opin Urol 2020 Mar;30(2):251-257

Department of Urology, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA.

Purpose Of Review: Early-stage testicular cancers are highly curable. Following orchidectomy, management options for stage I disease include active surveillance, nerve-sparing retroperitoneal lymph node dissection (nsRPLND) and primary chemotherapy as recommended by the current guidelines. Primary RPLND has for decades played an integral part of treatment in patients with early-stage testicular germ cell tumors (TGCT), particularly in nonseminomatous germ cell tumors (NSGCT) with focus on reducing the long-term morbidity. Read More

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http://dx.doi.org/10.1097/MOU.0000000000000736DOI Listing

The role of micro-RNAs in management of germ cell tumors: future directions.

Curr Opin Urol 2020 Mar;30(2):258-263

Testicular Cancer Commons, Beaverton.

Purpose Of Review: miRNAs 371 and 302/367 clusters are abundantly secreted in the blood of patients with active germ cell malignancy (aGCM), both seminoma and nonseminoma. The serum concentration of those micro-RNAs correlates with tumor burden and to the activity of specific treatments; therefore, representing attractive biomarkers for the diagnosis and follow-up of patients with germ cell tumors. This review summarizes the most relevant evidence supporting their clinical validity in germ cell tumors. Read More

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http://dx.doi.org/10.1097/MOU.0000000000000726DOI Listing

A RETROPERITONEAL SEMINOMA WITH ENTRAPPED NERVE GANGLION MASQUERADING AS A PARAGANGLIOMA.

AACE Clin Case Rep 2019 Sep-Oct;5(5):e321-e325. Epub 2019 Jun 26.

Objective: The differential diagnosis of retroperito-neal tumors includes lymphoid, germ cell, and neurogenic tumors such as paraganglioma. Paragangliomas are rare neuroendocrine tumors of the autonomic nervous system, which may secrete catecholamines and their metabolites. Clinical features include sustained or paroxysmal hypertension, headaches, sweating, and palpitations. Read More

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http://dx.doi.org/10.4158/ACCR-2019-0251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6876950PMC

MicroRNA and transcription factor co-regulatory networks and subtype classification of seminoma and non-seminoma in testicular germ cell tumors.

Sci Rep 2020 Jan 21;10(1):852. Epub 2020 Jan 21.

Center for Precision Health, School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX, USA.

Recent studies have revealed that feed-forward loops (FFLs) as regulatory motifs have synergistic roles in cellular systems and their disruption may cause diseases including cancer. FFLs may include two regulators such as transcription factors (TFs) and microRNAs (miRNAs). In this study, we extensively investigated TF and miRNA regulation pairs, their FFLs, and TF-miRNA mediated regulatory networks in two major types of testicular germ cell tumors (TGCT): seminoma (SE) and non-seminoma (NSE). Read More

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http://dx.doi.org/10.1038/s41598-020-57834-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6972857PMC
January 2020