1,098 results match your criteria Seminars in diagnostic pathology[Journal]


Infective dermatitis: A purely cutaneous manifestation of HTLV-1 infection.

Semin Diagn Pathol 2019 Apr 17. Epub 2019 Apr 17.

Dermatology and Pathology, Universidad Peruana Cayetano Heredia, Attending physican, Pathology service, Hospital Cayetano Heredia, Angamos 896 Miraflores, Lima 18, Peru. Electronic address:

Infectious dermatitis is a cutaneous manifestation of HTLV-1 infection. Although initially described in children in Jamaica, it is well documented that the disease can also present in adults. The clinical picture is of an oozing dermatitis affecting the scalp, face, retroauricular areas, the neck, and intertrigious areas, such as the axilla and groin. Read More

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http://dx.doi.org/10.1053/j.semdp.2019.04.002DOI Listing

Caring for patients with Ebola virus disease: Are U.S. biocontainment centers ready for the next outbreak?

Semin Diagn Pathol 2019 Apr 17. Epub 2019 Apr 17.

Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Room H-185D, Atlanta, GA 30322, USA.

The 2014 West African Ebola virus disease (EVD) outbreak is the largest and deadliest EVD epidemic to date, resulting in fivefold more cases than all other outbreaks combined. This outbreak was particularly devastating to healthcare workers in West Africa and resulted in several EVD patients being medically evacuated for treatment in the U.S. Read More

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http://dx.doi.org/10.1053/j.semdp.2019.04.007DOI Listing

Emerging and reemerging fungal infections.

Semin Diagn Pathol 2019 Apr 17. Epub 2019 Apr 17.

Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, United States.

Fungal infections throughout the world appear to be increasing. This may in part be due to the increase in the population of patients that are susceptible to otherwise rare fungal infections resulting from the use of immune modulating procedures such as hematopoietic stem cell transplants and drugs like tissue necrosis factor antagonists. Histoplasma capsulatum, an endemic fungus throughout North and South America, is reemerging among HIV+ patients in Central and South America and among patients taking tissue necrosis factor antagonists and other biologics in North America. Read More

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http://dx.doi.org/10.1053/j.semdp.2019.04.010DOI Listing

Chagas disease as example of a reemerging parasite.

Semin Diagn Pathol 2019 Apr 17. Epub 2019 Apr 17.

Department of Pathology and Laboratory Medicine, Emory University, 1364 Clifton Rd, Atlanta, GA 30322, United States. Electronic address:

Trypanosoma cruzi, the protozoan that causes Chagas disease, is primarily transmitted by three main Triatomine vectors in endemic areas. However, the infection has become a potential emerging disease because the vector is found in non-endemic areas, there is migration of infected asymptomatic people that can infect the vector, become blood donors, or pass the disease vertically (congenital infections). Lastly, the disease can be acquired through contaminated food (oral transmission). Read More

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http://dx.doi.org/10.1053/j.semdp.2019.04.008DOI Listing
April 2019
1 Read

Four human diseases with significant public health impact caused by mosquito-borne flaviviruses: West Nile, Zika, dengue and yellow fever.

Semin Diagn Pathol 2019 Apr 17. Epub 2019 Apr 17.

Anatomic Pathology and Molecular Oncology, University of Utah, Salt Lake City, UT, United States.

In this review we will discuss the epidemiology, clinical characteristics, diagnostic tests, pathologic features, treatment and disease prevention strategies for four mosquito-borne flaviviruses. West Nile and Zika viruses, once thought to be restricted geographically, emerged on the American continent in the first part of the 21st century. They have been constantly in the lay press and have caused a heightened awareness of emerging infections by the public, particularly given the manifestation of microcephaly in congenital Zika syndrome. Read More

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http://dx.doi.org/10.1053/j.semdp.2019.04.009DOI Listing

Introduction: One health and emerging infectious diseases.

Semin Diagn Pathol 2019 Apr 16. Epub 2019 Apr 16.

Department of Pathology and Laboratory Medicine, Emory University, 1364 Clifton Rd, Atlanta, GA 30322, United States. Electronic address:

Those infectious diseases that have increased in the past two decades or that threaten to emerge are considered emerging infectious diseases. Many of these diseases are acquired through contact with plants, insects and animals. "One health" acknowledges the interconnectedness of environment, plant, animal and human health. Read More

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http://dx.doi.org/10.1053/j.semdp.2019.04.004DOI Listing

Paraneoplastic syndromes and other systemic disorders associated with neuroendocrine neoplasms.

Semin Diagn Pathol 2019 Mar 18. Epub 2019 Mar 18.

Department of Pathology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114-2696, United States. Electronic address:

Neuroendocrine paraneoplastic syndromes (PNS) consist of metabolic disorders that accompany benign and malignant neoplasms but remain unrelated to mass effects or invasion by the primary tumor or its metastases. The underlying pathogenesis responsible for PNS usual clinical presentation rely on aberrant production of protein hormones, proteins and other substances by the tumor. Prompt recognition of characteristic signs and symptoms combined with serological identification of key substances may result in early diagnosis of PNS and its underlying malignancy. Read More

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March 2019
10 Reads

Paraneoplastic syndromes: Definitions, classification, pathophysiology and principles of treatment.

Authors:
Kristin Henry

Semin Diagn Pathol 2019 Feb 1. Epub 2019 Feb 1.

Imperial College London, Charing Cross Hospital Campus, Department of Histopathology, Fulham Place Road, London W6 8RF, United Kingdom. Electronic address:

Paraneoplastic syndromes (PNS) are rare clinical syndromes due to the systemic effects of tumours; they are unrelated to tumour size, invasiveness or metastases. Recent years have seen considerable advances leading to improved understanding of their pathophysiology and increased recognition of new PNS entities and PNS associated tumours. While of paramount importance, diagnosis is still frequently missed or delayed. Read More

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February 2019
1 Read

Paraneoplastic syndromes-"keys" to histopathological diagnoses and appropriate therapy.

Semin Diagn Pathol 2019 Mar 7. Epub 2019 Mar 7.

Divisions of Surgical Pathology, Cytopathology, & Autopsy Pathology, University of Virginia Health System, Charlottesville, VA, USA.

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http://dx.doi.org/10.1053/j.semdp.2019.03.001DOI Listing
March 2019
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Molecular updates in adipocytic neoplasms.

Semin Diagn Pathol 2019 Mar 28;36(2):85-94. Epub 2019 Feb 28.

Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, and Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada. Electronic address:

Adipocytic neoplasms include a diversity of both benign tumors (lipomas) and malignancies (liposarcomas), and each tumor type is characterized by its own unique molecular alterations driving tumorigenesis. Work over the past 30 years has established the diagnostic utility of several of these characteristic molecular alterations (e.g. Read More

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http://dx.doi.org/10.1053/j.semdp.2019.02.003DOI Listing
March 2019
2 Reads

A contemporary review of myxoid adipocytic tumors.

Authors:
David Creytens

Semin Diagn Pathol 2019 Mar 28;36(2):129-141. Epub 2019 Feb 28.

Department of Pathology, Ghent University and Ghent University Hospital, Corneel Heymanslaan 10, 9000 Ghent, Belgium; CRIG, Cancer Research Institute Ghent, Ghent University and Ghent University Hospital, Ghent, Belgium. Electronic address:

Myxoid adipocytic tumors encompass a broad heterogeneous group of benign and malignant adipocytic tumors, which are typically myxoid (e.g. myxoid liposarcoma, lipoblastoma and lipoblastoma-like tumor of the vulva) or may occasionally appear predominantly myxoid (e. Read More

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http://dx.doi.org/10.1053/j.semdp.2019.02.008DOI Listing
March 2019
1 Read

Introduction.

Authors:
Vickie Jo

Semin Diagn Pathol 2019 Mar 28;36(2):83-84. Epub 2019 Feb 28.

Department of Pathology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA, 02115, USA. Electronic address:

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Pleomorphic liposarcoma: Updates and current differential diagnosis.

Semin Diagn Pathol 2019 Mar 28;36(2):122-128. Epub 2019 Feb 28.

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, United States. Electronic address:

Pleomorphic liposarcoma is the least common but most aggressive subtype of liposarcoma. Tumors most commonly arise in the deep soft tissues of the extremities in adult patients. Pleomorphic liposarcoma has no specific immunohistochemical or molecular genetic features, and the presence of lipoblasts remains the sole diagnostic criterion. Read More

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http://dx.doi.org/10.1053/j.semdp.2019.02.007DOI Listing

Well-differentiated liposarcoma and dedifferentiated liposarcoma: An updated review.

Authors:
Khin Thway

Semin Diagn Pathol 2019 Mar 28;36(2):112-121. Epub 2019 Feb 28.

Sarcoma Unit, Royal Marsden Hospital, 203 Fulham Road, London SW3 6JJ, United Kingdom. Electronic address:

Well-differentiated liposarcoma (WDL)/atypical lipomatous tumor and dedifferentiated liposarcoma (DDL) together comprise the largest subgroup of liposarcomas, and constitute a histologic and behavioral spectrum of one disease. WDL and DDL typically occur in middle-aged to older adults, particularly within the retroperitoneum or extremities. WDL closely resembles mature adipose tissue, but typically shows fibrous septation with variable nuclear atypia and enlargement. Read More

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http://dx.doi.org/10.1053/j.semdp.2019.02.006DOI Listing

Adipocytic tumors in Children: A contemporary review.

Semin Diagn Pathol 2019 Mar 28;36(2):95-104. Epub 2019 Feb 28.

Department of Pathology, Children's Hospital Boston and Harvard Medical School, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, United States. Electronic address:

Adipocytic neoplasms in the pediatric population demonstrate a different histologic spectrum and frequency than in adults. The vast majority of these tumors are benign, with lipoma being the most common entity. The identification of signature cytogenetic and molecular alterations for certain lesions, such as PLAG1 gene rearrangement in lipoblastoma and FUS-DDIT3 fusion in myxoid liposarcoma, has been helpful in approaching these neoplasms and aiding in confirming the diagnosis. Read More

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March 2019
5 Reads
1.796 Impact Factor

Updates in spindle cell/pleomorphic lipomas.

Semin Diagn Pathol 2019 Mar 28;36(2):105-111. Epub 2019 Feb 28.

Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street, SW, Rochester, MN 55905, USA. Electronic address:

Spindle cell/pleomorphic lipomas are benign lipomatous neoplasms that show loss of RB1 and classically harbor components of mature adipose tissue, bland spindled cells and ropy collagen. This review highlights the clinicopathologic features and morphologic spectrum of spindle cell/pleomorphic lipoma, discusses an updated differential diagnosis, and provides a practical diagnostic strategy for spindle cell/pleomorphic lipomas with atypical clinical presentations. Read More

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http://dx.doi.org/10.1053/j.semdp.2019.02.005DOI Listing

Paraneoplastic disorders associated with miscellaneous neoplasms with focus on selected soft tissue and Undifferentiated/ rhabdoid malignancies.

Authors:
Abbas Agaimy

Semin Diagn Pathol 2019 Feb 20. Epub 2019 Feb 20.

Institute of Pathology, Friedrich-Alexander-University Erlangen-Nürnberg, University Hospital Erlangen, Germany. Electronic address:

A variety of soft tissue and visceral neoplasms have been associated with constitutional symptoms and signs including fever, fatigue, arthritis and laboratory abnormalities such as elevated erythrocyte sedimentation rate, leukocytosis with marked neutrophilia, anemia, thrombocytosis and others. This review addresses three main neoplastic categories that are associated with specific paraneoplastic phenomena: (1) neoplasms having in common the presence of diffuse mixed inflammatory infiltration (closely simulating an inflammatory pseudotumor) and frequently associated with constitutional symptoms; (2) neoplasms with undifferentiated, anaplastic or rhabdoid cell morphology (frequently SWI/SNF-deficient) associated with diverse paraneoplastic manifestations; and (3) paraneoplasia associated with neoplasms carrying specific gene fusions such as solitary fibrous tumor (STAT6-NAB2 gene fusions), infantile fibrosarcoma and congenital mesoblastic nephroma (ETV6-NTRK3 gene fusions), and angiomatoid fibrous histiocytoma (EWSR1-CREB1 & EWSR1-ATF1 fusions). Read More

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http://dx.doi.org/10.1053/j.semdp.2019.02.001DOI Listing
February 2019
2 Reads

Gynecological neoplasms associated with paraneoplastic hypercalcemia.

Authors:
D Lim E Oliva

Semin Diagn Pathol 2019 Feb 1. Epub 2019 Feb 1.

Department of Pathology, Massachusetts General Hospital, Boston, MA, USA.

Approximately 5% of gynecological malignancies are associated with paraneoplastic hypercalcemia. Awareness of its association with certain tumor types allows for earlier disease detection and facilitates monitoring of treatment response and disease recurrence. We review the salient clinicopathological features, differential diagnosis and management issues in some of these gynecological tumors, namely: small cell carcinoma, hypercalcemic type; ovarian clear cell carcinoma, dysgerminoma and juvenile granulosa cell tumors. Read More

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http://dx.doi.org/10.1053/j.semdp.2019.01.003DOI Listing
February 2019
1 Read

Cutaneous paraneoplastic syndromes.

Semin Diagn Pathol 2019 Jan 31. Epub 2019 Jan 31.

PRW Laboratories, Charlottesville, VA, United State.

A variety of cutaneous abnormalities can be seen in patients with malignant diseases, some of which are infectious, with others representing direct involvement of the skin by the underlying disorder. Yet another group of lesions can be regarded as associated markers of the malignant process, and, as such, are termed "paraneoplastic." This review considers the latter collection of conditions, grouping them by the generic type of malignancy that is usually linked to the paraneoplasia. Read More

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http://dx.doi.org/10.1053/j.semdp.2019.01.001DOI Listing
January 2019
15 Reads

Hamartomas and malformations of the liver.

Semin Diagn Pathol 2019 Jan 17;36(1):39-47. Epub 2018 Nov 17.

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, United States. Electronic address:

Hamartomas and malformations of the liver are rare and can lead to diagnostic challenges. Most present as mass lesions that can mimic true neoplasms of the liver on imaging and sometimes on histology, one example being focal nodular hyperplasia. The primary cell type in the hamartomas and malformations can be biliary, vascular, or hepatic. Read More

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http://dx.doi.org/10.1053/j.semdp.2018.11.005DOI Listing
January 2019
5 Reads

Hamartomas of skin and soft tissue.

Semin Diagn Pathol 2019 Jan 11;36(1):48-61. Epub 2018 Dec 11.

Department of Pathology and Cell Biology - USF Health, Ruffolo, Hooper, and Associates, Tampa, FL, United States. Electronic address:

Hamartomas are benign lesions composed of aberrant disorganized growth of mature tissues. Choristomas are similar, except that they are composed of tissues not normally found at the anatomic site in which the lesion is arising. A wide range of hamartomas and choristomas can arise in the skin and soft tissue. Read More

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http://dx.doi.org/10.1053/j.semdp.2018.12.001DOI Listing
January 2019
2 Reads

Developmental disorders and malformations of the breast.

Semin Diagn Pathol 2019 Jan 17;36(1):11-15. Epub 2018 Nov 17.

Department of Pathology, Emory University Hospital, Atlanta, GA 30322, United States. Electronic address:

Developmental abnormalities and malformations of the breast are rare and encompass a variety of genetic, syndromic, acquired and sporadic conditions. Abnormalities in development may include irregularities in the nipple areolar complex and/or the underlying glandular tissue, resulting in under or overdevelopment of breasts. Age of presentation and clinical severity is dependent on the underlying biologic cause. Read More

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http://dx.doi.org/10.1053/j.semdp.2018.11.007DOI Listing
January 2019
6 Reads

Preface-Hamartomas & choristomas.

Authors:
Mark R Wick

Semin Diagn Pathol 2019 Jan 17;36(1). Epub 2018 Nov 17.

Charlottesville, VA, USA. Electronic address:

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http://dx.doi.org/10.1053/j.semdp.2018.11.001DOI Listing
January 2019
1 Read

Diagnostic histochemistry in non-neoplastic skin diseases.

Semin Diagn Pathol 2018 Nov 16;35(6):390-398. Epub 2018 Oct 16.

PRW Laboratories, Charlottesville, VA, USA.

Non-neoplastic skin lesions comprise a sizable group of disorders with variable etiologies and clinical manifestations. They can be grouped into vesiculopustular dermatitides; spongiotic and psoriasiform diseases; lichenoid dermatitides; lymphoid infiltrates of the dermis; granulomatous processes; bullous disorders; vasculopathies; panniculitides; deposition disorders; and defects in maintenance of dermal connective tissue. The use of histochemical methods continues to be an indispensable adjunct to conventional microscopy in the further characterization of such lesions. Read More

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http://dx.doi.org/10.1053/j.semdp.2018.10.006DOI Listing
November 2018
5 Reads

Hamartoma, choristomas and malformation of the spleen and lymph node.

Semin Diagn Pathol 2019 Jan 16;36(1):16-23. Epub 2018 Nov 16.

Joint Pathology Center, Silver Spring, MD, United States.

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http://dx.doi.org/10.1053/j.semdp.2018.11.003DOI Listing
January 2019
2 Reads

Malformations, choristomas, and hamartomas of the gastrointestinal tract and pancreas.

Semin Diagn Pathol 2019 Jan 16;36(1):24-38. Epub 2018 Nov 16.

Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.

Congenital and hamartomatous lesions of the gastrointestinal tract cause diagnostic challenges for surgical pathologists. Many of these are merely histologic curiosities, whereas others have substantial clinical implications because they herald cancer syndromes or associated anomalies. Although a comprehensive discussion of all developmental abnormalities that can occur in the gastrointestinal tract is beyond the scope of a single manuscript, some entities are more likely to be encountered by surgical pathologists, have important clinical consequences, or pose diagnostic difficulties. Read More

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http://dx.doi.org/10.1053/j.semdp.2018.11.004DOI Listing
January 2019
1 Read

Hamartomas and other tumor-like malformations of the lungs and heart.

Authors:
Mark R Wick

Semin Diagn Pathol 2019 Jan 16;36(1):2-10. Epub 2018 Nov 16.

Division of Surgical Pathology-Cytopathology & Autopsy Pathology, University of Virginia Medical Center, Room 3020, 1215 Lee Street, Charlottesville, VA 22908-0214, United States. Electronic address:

Tumor-like malformative lesions are seen throughout the body, and they may be confused with true neoplasms by clinicians and pathologists alike. In the lungs, they are principally represented by hamartomas-which may contain chondroid, adipocytic, fibroblastic, and myxoid tissue, with entrapped bronchiolar epithelium-and congenital pulmonary airway malformations (CPAMs). The latter have been subdivided into 5 groups, based on their histological features, but they basically comprise proliferations of malformed bronchopulmonary tissues of different types. Read More

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January 2019
21 Reads

Hamartomas and choristomas in the nervous system.

Authors:
Cynthia T Welsh

Semin Diagn Pathol 2019 Jan 16;36(1):62-70. Epub 2018 Nov 16.

Departments of Pathology, Laboratory Medicine, and Neuroscience, 171 Ashley Avenue, MSC 908 Medical University of South Carolina, Charleston, SC 29425-9080, United States. Electronic address:

Hamartomas are an overgrowth of mature tissues that normally occur in an area of the body, but with disorganization and often with one element predominating. Choristomas on the other hand, are a mass of tissue histologically normal for a part of the body other than the one in which it is located (heterotopic/ectopic). Many reports use choristoma and heterotopia interchangeably. Read More

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January 2019
2 Reads

Diagnostic histochemistry in neuropathology.

Semin Diagn Pathol 2019 Jan 16;36(1):71-82. Epub 2018 Oct 16.

Division of Neuropathology, Department of Pathology, University of Virginia Medical Center, Charlottesville, VA, United States. Electronic address:

Neuropathologists have a long and storied history of utilizing histochemistry in the characterization and diagnosis of neurological diseases. This review considers stains that are used for the identification of neurons, neuritic processes and axons, myelin sheaths, neuroglial cells, and connective tissue in the nervous system. Rapid histochemical-smear methods for intraoperative diagnosis are also discussed, along with possible roles for lectin-histochemistry in diagnostic neuropathology. Read More

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http://dx.doi.org/10.1053/j.semdp.2018.10.004DOI Listing
January 2019
3 Reads

Diagnostic histochemistry in hepatic pathology.

Authors:
Julia C Iezzoni

Semin Diagn Pathol 2018 Nov 16;35(6):381-389. Epub 2018 Oct 16.

Division of Surgical Pathology and Cytopathology, Department of Pathology, University of Virginia Health System, P.O. Box 800214, Charlottesville, VA 22908, United States. Electronic address:

Histochemistry has an important, continuing role in the current assessment of hepatic biopsies and resection specimens. The evaluation of connective tissue elements in the liver can be accomplished with such methods as the Masson trichrome, Snook reticulin, Vierhoff van Gieson, orcein, and Victoria blue stains. The results contribute to the diagnosis of acute and chronic hepatitis, submassive necrosis, venous outflow obstruction, steatohepatitis, and cirrhosis. Read More

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November 2018
17 Reads

Diagnostic histochemistry in medical diseases of the kidney.

Semin Diagn Pathol 2018 Nov 16;35(6):360-369. Epub 2018 Oct 16.

Department of Pathology, Baylor College of Medicine, Houston, TX, United States.

The value of histochemical analysis in the diagnosis of medical renal diseases has long been known, and its use continues currently. Depending on the particular disorder in question, a variety of "special" stains may be applied to renal biopsies. These include the periodic acid-Schiff, Masson trichrome, Jones, von Kossa, Verhoeff-van Gieson, Congo Red, and toluidine blue methods, among others. Read More

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November 2018
20 Reads

Diagnostic histochemistry of soft tissue lesions.

Semin Diagn Pathol 2018 Nov 16;35(6):399-406. Epub 2018 Oct 16.

Johns Hopkins Medical Institutions, Baltimore, MD, United States. Electronic address:

Histochemical methods (HM) were, at one time, extensively used in all facets of anatomic pathology, including analysis of soft tissue lesions. That situation has changed with the advent of other adjunctive procedures, but HM still do contribute meaningfully to the evaluation of several tumefactive conditions in the soft tissue. This brief review considers selected neoplastic, quasineoplastic, and pseudoneoplastic lesions in that category, with emphasis on their histochemical properties. Read More

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November 2018
4 Reads

Diagnostic histochemistry: A historical perspective.

Authors:
Mark R Wick

Semin Diagn Pathol 2018 Nov 16;35(6):354-359. Epub 2018 Oct 16.

Divisions of Surgical Pathology & Cytopathology and Autopsy Pathology, University of Virginia Medical Center, 1215 Lee St., Charlottesville, VA 22908-0214, USA. Electronic address:

Histochemistry has a history which, in some ways, goes back to ancient times. The desire for humans to understand the workings of their bodies, and the roles that various chemicals have in them, is long-standing. This review considers the evolution of histochemistry and cytochemistry as scientific disciplines, culminating in the pairing of those techniques with basic biochemistry. Read More

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November 2018
1 Read

Histochemistry in the diagnosis of non-neoplastic gastrointestinal disorders.

Semin Diagn Pathol 2018 Nov 16;35(6):370-380. Epub 2018 Oct 16.

Department of Pathology, St. Jude Medical Center, Fullerton, CA 92835, United States. Electronic address:

The alimentary tract serves as host to a large number of diseases. In the non-neoplastic group of disorders, conventional histochemistry continues to play an important diagnostic role. It is particularly important in recognizing specific infectious diseases, such as Helicobacter gastritis, Whipple disease, intestinal tuberculosis and other forms of mycobacteriosis, malakoplakia, intestinal spirochetosis, fungal enteritides, amebiasis, cryptosporidiosis, isosporiasis, and microsporidiosis. Read More

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November 2018
26 Reads

"What the world, social and political, concrete and mental, really needs is not new things, but the old things made new." Ethel M. Dell.

Authors:
Mark R Wick

Semin Diagn Pathol 2018 Nov 17;35(6):353. Epub 2018 Oct 17.

University of Virginia Medical Center, Charlottesville, VA. Electronic address:

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November 2018
6 Reads

Reprint of: The pathology of pulmonary sarcoidosis: update.

Semin Diagn Pathol 2018 Sep 24;35(5):324-333. Epub 2018 Sep 24.

Department of Lung Pathologist, KEck Medical Center of USC, Los Angeles, California. Electronic address:

Sarcoidosis is a multi-system disease of unknown etiology, usually affecting the respiratory tract and other organs, and is characterized by the formation of nonnecrotizing epithelioid granulomas. The diagnosis depends on a combination of a typical clinicoradiological presentation, the finding of nonnecrotizing epithelioid granulomas in a tissue biopsy, and exclusion of other possible diseases, especially those of infectious etiology. The granulomas contain epithelioid cells, giant cells, CD4+ T cells in their center, and CD8+ T lymphocytes and B lymphocytes at their periphery. Read More

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September 2018
9 Reads

Reprint of: Nonspecific interstitial pneumonia: pathologic features and clinical implications.

Authors:
Jeffrey L Myers

Semin Diagn Pathol 2018 Sep 8;35(5):334-338. Epub 2018 Sep 8.

Division of Anatomic Pathology, The University of Michigan, Ann Arbor, Michigan. Electronic address:

Nonspecific interstitial pneumonia (NSIP) is a form of chronic interstitial pneumonia that should be separated from the other idiopathic interstitial pneumonias, including most importantly, usual interstitial pneumonia (UIP). Diagnosis is predicated on identification of characteristic findings in a surgical lung biopsy in the appropriate clinical and radiological context. Affected patients may have a variety of underlying or associated conditions, although most have a form of idiopathic lung disease associated with a more favorable prognosis than UIP/idiopathic pulmonary fibrosis (IPF). Read More

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http://dx.doi.org/10.1053/j.semdp.2018.09.002DOI Listing
September 2018
1 Read

Reprint of: Unusual non-neoplastic lesions of the lung.

Semin Diagn Pathol 2018 Sep 8;35(5):339-346. Epub 2018 Sep 8.

Department of Pathology, Medical College of Wisconsin, Milwaukee, Wisconsin.

Many nonneoplastic conditions that may affect the lung are in reality rare or unusual manifestations of metabolic processes, inflammatory conditions, or unknown etiology. Because of their rarity, they can often be confused with malignant neoplasms. Familiarity with these conditions not only will expedite further treatment for these patients but also will avoid the process of more tests or unnecessary surgical procedures. Read More

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http://dx.doi.org/10.1053/j.semdp.2018.09.003DOI Listing
September 2018
1 Read

Reprint of: Pathologic manifestations of Immunoglobulin(Ig)G4-related lung disease.

Semin Diagn Pathol 2018 Sep 8;35(5):347-351. Epub 2018 Sep 8.

Department of Laboratory Medicine and Pathology, Mayo Clinic, Scottsdale, Arizona.

Immunoglobulin(Ig)G4-related disease (IgG4-RD) is a fibroinflammatory condition that can affect virtually any organ and usually presents as tumefactive lesions involving multiple sites. Characteristic histopathology of IgG4-RD consists of dense lymphoplasmacytic infiltrate, fibrosis (often in storiform pattern), and obliterative phlebitis, accompanied by tissue infiltration of IgG4-positive plasma cells with or without elevation of serum IgG4 level. Despite a general similarity in the morphologic manifestations of IgG4-RD, site-specific unique morphologic features have been described in some organs including the lung. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07402570183007
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http://dx.doi.org/10.1053/j.semdp.2018.09.004DOI Listing
September 2018
24 Reads

Interstitial lung disease: Elementary lesions and diagnosis.

Semin Diagn Pathol 2018 Sep 13;35(5):288-296. Epub 2018 Aug 13.

Department of Pathology, Abderrahman Mami Hospital, Tunisia; Université Tunis El Manar, Faculté de Médecine de Tunis, Tunisia.

An effective approach to the diagnosis of interstitial lung diseases requires a standardized method of evaluation with a structured analysis, beginning with scanning microscopy and proceeding to a more detailed assessment. This article is structured around the histologic patterns defined by Leslie that facilitate this process. They include acute injury, fibrosis, cellular infiltrates, airspace filling, formation of nodules, and minimal changes. Read More

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http://dx.doi.org/10.1053/j.semdp.2018.08.001DOI Listing
September 2018
1 Read

Pulmonary disorders that are potentially associated with anti- neutrophilic cytoplasmic antibodies: A brief review.

Authors:
Mark R Wick

Semin Diagn Pathol 2018 Sep 24;35(5):304-314. Epub 2018 Aug 24.

Division of Surgical Pathology and Cytopathology, University of Virginia Medical Center, Charlottesville, VA, United States. Electronic address:

Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis frequently manifests with involvement of the lungs and kidneys, and it also may affect other anatomic sites. This article presents the patterns of pulmonary injury in which ANCA-associated vasculitis is included in the differential diagnosis, with a discussion of antineutrophil cytoplasmic antibody testing methods. The histologic features of non-vasculitic, potentially-ANCA-associated pulmonary lesions are reviewed briefly as well. Read More

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http://dx.doi.org/10.1053/j.semdp.2018.08.005DOI Listing
September 2018
5 Reads

Introduction.

Semin Diagn Pathol 2018 Sep 16;35(5):279. Epub 2018 Aug 16.

Department of Pathology, University of Virginia Medical Center, Charlottesville, VA, USA. Electronic address:

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http://dx.doi.org/10.1053/j.semdp.2018.08.004DOI Listing
September 2018
8 Reads

The utility of bronchoalveolar lavage in the evaluation of interstitial lung diseases: A clinicopathological perspective.

Semin Diagn Pathol 2018 Sep 24;35(5):280-287. Epub 2018 Aug 24.

Department of Pathology, Abderrahman Mami Hospital, Ariana, Tunis, Tunisia; University Tunis El Manar, Tunis, Tunisia.

Bronchoalveolar lavage (BAL) is a noninvasive and well-tolerated procedure that is performed with a fiberoptic bronchoscope in the wedged position within a selected bronchopulmonary segment. After it was introduced to clinical practice, BAL rapidly gained acceptance in a large number of centers as a procedure that could be applied to the clinical evaluation of patients with various pulmonary disorders, especially the group of interstitial lung diseases (ILD). Cytological and flow cytometric analysis of BAL fluid in ILD is done with knowledge of the clinical presentation and radiological findings. Read More

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http://dx.doi.org/10.1053/j.semdp.2018.08.003DOI Listing
September 2018
6 Reads

Interstitial lung diseases: Imaging contribution to diagnosis and elementary radiological lesions.

Semin Diagn Pathol 2018 Sep 10;35(5):297-303. Epub 2018 Aug 10.

Imaging Department, Abderrahmen Mami Hospital, Ariana, Tunisia; Faculty of Medicine of Tunis, Tunis El Manar University, Tunisia.

Interstitial pneumonias comprise a heterogeneous group of disorders in which a multidisciplinary approach is important for accuracy in diagnosis; indeed, one might say, even mandatory. The team of collaborators should include radiologists, because high resolution computed tomography (HRCT) of the thorax is the first, and most of times, the only imaging examination to be prescribed after chest X-ray. Elementary lesions of the interstitium can be accurately described with HRCT, inasmuch as lung windowing with sharp filtering in this technique reproduces the microscopic features of the lung. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07402570183004
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http://dx.doi.org/10.1053/j.semdp.2018.07.001DOI Listing
September 2018
6 Reads

Pathologic features of smoking-related lung diseases, with emphasis on smoking-related interstitial fibrosis and a consideration of differential diagnoses.

Authors:
Mark R Wick

Semin Diagn Pathol 2018 Sep 10;35(5):315-323. Epub 2018 Aug 10.

Division of Surgical Pathology & Cytopathology, University of Virginia Medical Center, Charlottesville, VA, USA. Electronic address:

Smoking-related interstitial fibrosis (SRIF) is frequently-seen and morphologically-distinctive finding in the lung tissue of cigarette smokers. It can be distinguished histologically from the idiopathic interstitial pneumonias and other causes of pulmonary interstitial fibrosis. SRIF is typified by dense thickening of the alveolar septa by thick collagen bundles with a hyalinized appearance, with the common admixture of bands of hyperplastic smooth muscle. Read More

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http://dx.doi.org/10.1053/j.semdp.2018.08.002DOI Listing
September 2018
9 Reads

Iatrogenic lesions-Preface.

Authors:
Mark R Wick

Semin Diagn Pathol 2018 Jul 19;35(4):207. Epub 2018 Apr 19.

University of Virginia Medical Center, University of Virginia Hospital Division of Surgical Pathology & Cytopathology, 2666 Coralberry Place, Charlottesville, VA 22911-8276, United States. Electronic address:

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http://dx.doi.org/10.1053/j.semdp.2018.04.001DOI Listing
July 2018
2 Reads

Iatrogenic pulmonary lesions.

Semin Diagn Pathol 2018 Jul 23;35(4):260-271. Epub 2018 Mar 23.

Service de Pneumologie et Soins Intensifs Respiratoires, Hopital du Bocage Centre Hospitalier Universitaire (CHU) de Bourgogne, Dijon, France; UFR des Sciences de Santé, Université de Bourgogne, Dijon, France; INSERM U866, Faculté de Médecine, Dijon, France.

Treatment of patients often includes the administration of medications and sometimes radiation. While the intent is to treat an underlying condition, in some cases, adverse effects occur due to these agents. Most of these adverse effects are mild, however, some can be severe and life-threatening. Read More

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http://dx.doi.org/10.1053/j.semdp.2018.03.002DOI Listing
July 2018
26 Reads

Reexamining post-transplant lymphoproliferative disorders: Newly recognized and enigmatic types.

Semin Diagn Pathol 2018 Jul 3;35(4):236-246. Epub 2018 Mar 3.

University of Virginia Health System, 1215 Lee Street, Box 800214, Charlottesville, VA, United States.. Electronic address:

Post-transplant lymphoproliferative disorders (PTLD) are a known risk for both solid organ transplant and stem cell transplant recipients. Overall transplant recipients have a six fold increase in risk for developing any kind of non-Hodgkin lymphoma and PTLDs occur in up to 10% of SOT recipients. Several new entities have been accepted or renamed in the 2018 update of the WHO classification of tumors of hematopoietic and lymphoid neoplasms, including florid follicular hyperplasia and extranodal marginal zone lymphomas of mucosa-associated lymphoid tissue (MALT-lymphoma) (excluding common locations such as stomach and salivary gland). Read More

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http://dx.doi.org/10.1053/j.semdp.2018.02.001DOI Listing
July 2018
6 Reads

Iatrogenic pathology of the urinary bladder.

Semin Diagn Pathol 2018 Jul 14;35(4):218-227. Epub 2018 Mar 14.

Department of Pathology, University at Alabama Birmingham School of Medicine, Birmingham, AL, USA.

Intravesical immunotherapy, chemotherapy, and neoadjuvant systemic chemotherapy are among the most frequent therapeutic procedures to treat malignancies of the urinary bladder. These treatment modalities produce reactive morphologic changes in the urothelium that can mimic urothelial carcinoma in situ, urothelial dysplasia or true invasive urothelial neoplasia. Mitomycin C used after transurethral resection of bladder tumor to reduce recurrences, BCG intravesical immunotherapy to treat high risk non-muscle invasive bladder cancer and urothelial carcinoma in situ, and platinum-based systemic chemotherapy to improve post-cystectomy disease-specific survival some of the causes of therapy related atypia in urinary bladder. Read More

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http://dx.doi.org/10.1053/j.semdp.2018.03.001DOI Listing
July 2018
9 Reads

Morphological clues to the appropriate recognition of hereditary renal neoplasms.

Semin Diagn Pathol 2018 May 14;35(3):184-192. Epub 2018 Feb 14.

Department of Pathology and Laboratory Medicine, University of Tennessee Health Sciences, Memphis, USA; Department of Urology, University of Tennessee Health Sciences, Memphis, USA.

An important emerging role of the surgical pathologist besides the traditional tasks of establishment of the diagnosis and documentation of prognostic and predictive factors, is to recognize the possibility of a hereditary condition in cases where the histology is suggestive for a familial cancer syndrome. In recent years, the knowledge regarding all of the above roles, including the role of recognition of familial cancer, has particularly expanded in renal neoplasms with the close scrutiny to morphology, molecular correlates and clinical features of the different sub-types of renal cell carcinoma. Awareness of these clinically distinctive sub-types and their associated histologic clues will prompt the pathologist for further immunohistochemical or molecular work up, to look for clinical information to support the suspected diagnosis of familial cancer, to alert managing physician/s to look for stigmata of history of familial cancer, which will permit triaging patients and their families for appropriate genetic counseling. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07402570183000
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http://dx.doi.org/10.1053/j.semdp.2018.01.005DOI Listing
May 2018
12 Reads