1,080 results match your criteria Seminars in diagnostic pathology[Journal]


Cutaneous paraneoplastic syndromes.

Semin Diagn Pathol 2019 Jan 31. Epub 2019 Jan 31.

PRW Laboratories, Charlottesville, VA, United State.

A variety of cutaneous abnormalities can be seen in patients with malignant diseases, some of which are infectious, with others representing direct involvement of the skin by the underlying disorder. Yet another group of lesions can be regarded as associated markers of the malignant process, and, as such, are termed "paraneoplastic." This review considers the latter collection of conditions, grouping them by the generic type of malignancy that is usually linked to the paraneoplasia. Read More

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http://dx.doi.org/10.1053/j.semdp.2019.01.001DOI Listing
January 2019
1 Read

Hamartomas and malformations of the liver.

Semin Diagn Pathol 2019 Jan 17;36(1):39-47. Epub 2018 Nov 17.

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, United States. Electronic address:

Hamartomas and malformations of the liver are rare and can lead to diagnostic challenges. Most present as mass lesions that can mimic true neoplasms of the liver on imaging and sometimes on histology, one example being focal nodular hyperplasia. The primary cell type in the hamartomas and malformations can be biliary, vascular, or hepatic. Read More

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http://dx.doi.org/10.1053/j.semdp.2018.11.005DOI Listing
January 2019
3 Reads

Hamartomas of skin and soft tissue.

Semin Diagn Pathol 2019 Jan 11;36(1):48-61. Epub 2018 Dec 11.

Department of Pathology and Cell Biology - USF Health, Ruffolo, Hooper, and Associates, Tampa, FL, United States. Electronic address:

Hamartomas are benign lesions composed of aberrant disorganized growth of mature tissues. Choristomas are similar, except that they are composed of tissues not normally found at the anatomic site in which the lesion is arising. A wide range of hamartomas and choristomas can arise in the skin and soft tissue. Read More

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http://dx.doi.org/10.1053/j.semdp.2018.12.001DOI Listing
January 2019
2 Reads

Developmental disorders and malformations of the breast.

Semin Diagn Pathol 2019 Jan 17;36(1):11-15. Epub 2018 Nov 17.

Department of Pathology, Emory University Hospital, Atlanta, GA 30322, United States. Electronic address:

Developmental abnormalities and malformations of the breast are rare and encompass a variety of genetic, syndromic, acquired and sporadic conditions. Abnormalities in development may include irregularities in the nipple areolar complex and/or the underlying glandular tissue, resulting in under or overdevelopment of breasts. Age of presentation and clinical severity is dependent on the underlying biologic cause. Read More

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http://dx.doi.org/10.1053/j.semdp.2018.11.007DOI Listing
January 2019
5 Reads

Preface-Hamartomas & choristomas.

Authors:
Mark R Wick

Semin Diagn Pathol 2019 Jan 17;36(1). Epub 2018 Nov 17.

Charlottesville, VA, USA. Electronic address:

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January 2019
1 Read

Diagnostic histochemistry in non-neoplastic skin diseases.

Semin Diagn Pathol 2018 Nov 16;35(6):390-398. Epub 2018 Oct 16.

PRW Laboratories, Charlottesville, VA, USA.

Non-neoplastic skin lesions comprise a sizable group of disorders with variable etiologies and clinical manifestations. They can be grouped into vesiculopustular dermatitides; spongiotic and psoriasiform diseases; lichenoid dermatitides; lymphoid infiltrates of the dermis; granulomatous processes; bullous disorders; vasculopathies; panniculitides; deposition disorders; and defects in maintenance of dermal connective tissue. The use of histochemical methods continues to be an indispensable adjunct to conventional microscopy in the further characterization of such lesions. Read More

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http://dx.doi.org/10.1053/j.semdp.2018.10.006DOI Listing
November 2018
4 Reads

Hamartoma, choristomas and malformation of the spleen and lymph node.

Semin Diagn Pathol 2019 Jan 16;36(1):16-23. Epub 2018 Nov 16.

Joint Pathology Center, Silver Spring, MD, United States.

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January 2019
1 Read

Malformations, choristomas, and hamartomas of the gastrointestinal tract and pancreas.

Semin Diagn Pathol 2019 Jan 16;36(1):24-38. Epub 2018 Nov 16.

Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.

Congenital and hamartomatous lesions of the gastrointestinal tract cause diagnostic challenges for surgical pathologists. Many of these are merely histologic curiosities, whereas others have substantial clinical implications because they herald cancer syndromes or associated anomalies. Although a comprehensive discussion of all developmental abnormalities that can occur in the gastrointestinal tract is beyond the scope of a single manuscript, some entities are more likely to be encountered by surgical pathologists, have important clinical consequences, or pose diagnostic difficulties. Read More

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http://dx.doi.org/10.1053/j.semdp.2018.11.004DOI Listing
January 2019
1 Read

Hamartomas and other tumor-like malformations of the lungs and heart.

Authors:
Mark R Wick

Semin Diagn Pathol 2019 Jan 16;36(1):2-10. Epub 2018 Nov 16.

Division of Surgical Pathology-Cytopathology & Autopsy Pathology, University of Virginia Medical Center, Room 3020, 1215 Lee Street, Charlottesville, VA 22908-0214, United States. Electronic address:

Tumor-like malformative lesions are seen throughout the body, and they may be confused with true neoplasms by clinicians and pathologists alike. In the lungs, they are principally represented by hamartomas-which may contain chondroid, adipocytic, fibroblastic, and myxoid tissue, with entrapped bronchiolar epithelium-and congenital pulmonary airway malformations (CPAMs). The latter have been subdivided into 5 groups, based on their histological features, but they basically comprise proliferations of malformed bronchopulmonary tissues of different types. Read More

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http://dx.doi.org/10.1053/j.semdp.2018.11.002DOI Listing
January 2019
15 Reads

Hamartomas and choristomas in the nervous system.

Authors:
Cynthia T Welsh

Semin Diagn Pathol 2019 Jan 16;36(1):62-70. Epub 2018 Nov 16.

Departments of Pathology, Laboratory Medicine, and Neuroscience, 171 Ashley Avenue, MSC 908 Medical University of South Carolina, Charleston, SC 29425-9080, United States. Electronic address:

Hamartomas are an overgrowth of mature tissues that normally occur in an area of the body, but with disorganization and often with one element predominating. Choristomas on the other hand, are a mass of tissue histologically normal for a part of the body other than the one in which it is located (heterotopic/ectopic). Many reports use choristoma and heterotopia interchangeably. Read More

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January 2019
2 Reads

Diagnostic histochemistry in neuropathology.

Semin Diagn Pathol 2019 Jan 16;36(1):71-82. Epub 2018 Oct 16.

Division of Neuropathology, Department of Pathology, University of Virginia Medical Center, Charlottesville, VA, United States. Electronic address:

Neuropathologists have a long and storied history of utilizing histochemistry in the characterization and diagnosis of neurological diseases. This review considers stains that are used for the identification of neurons, neuritic processes and axons, myelin sheaths, neuroglial cells, and connective tissue in the nervous system. Rapid histochemical-smear methods for intraoperative diagnosis are also discussed, along with possible roles for lectin-histochemistry in diagnostic neuropathology. Read More

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http://dx.doi.org/10.1053/j.semdp.2018.10.004DOI Listing
January 2019
1 Read

Diagnostic histochemistry in hepatic pathology.

Authors:
Julia C Iezzoni

Semin Diagn Pathol 2018 Nov 16;35(6):381-389. Epub 2018 Oct 16.

Division of Surgical Pathology and Cytopathology, Department of Pathology, University of Virginia Health System, P.O. Box 800214, Charlottesville, VA 22908, United States. Electronic address:

Histochemistry has an important, continuing role in the current assessment of hepatic biopsies and resection specimens. The evaluation of connective tissue elements in the liver can be accomplished with such methods as the Masson trichrome, Snook reticulin, Vierhoff van Gieson, orcein, and Victoria blue stains. The results contribute to the diagnosis of acute and chronic hepatitis, submassive necrosis, venous outflow obstruction, steatohepatitis, and cirrhosis. Read More

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November 2018
13 Reads

Diagnostic histochemistry in medical diseases of the kidney.

Semin Diagn Pathol 2018 Nov 16;35(6):360-369. Epub 2018 Oct 16.

Department of Pathology, Baylor College of Medicine, Houston, TX, United States.

The value of histochemical analysis in the diagnosis of medical renal diseases has long been known, and its use continues currently. Depending on the particular disorder in question, a variety of "special" stains may be applied to renal biopsies. These include the periodic acid-Schiff, Masson trichrome, Jones, von Kossa, Verhoeff-van Gieson, Congo Red, and toluidine blue methods, among others. Read More

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November 2018
16 Reads

Diagnostic histochemistry of soft tissue lesions.

Semin Diagn Pathol 2018 Nov 16;35(6):399-406. Epub 2018 Oct 16.

Johns Hopkins Medical Institutions, Baltimore, MD, United States. Electronic address:

Histochemical methods (HM) were, at one time, extensively used in all facets of anatomic pathology, including analysis of soft tissue lesions. That situation has changed with the advent of other adjunctive procedures, but HM still do contribute meaningfully to the evaluation of several tumefactive conditions in the soft tissue. This brief review considers selected neoplastic, quasineoplastic, and pseudoneoplastic lesions in that category, with emphasis on their histochemical properties. Read More

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http://dx.doi.org/10.1053/j.semdp.2018.10.005DOI Listing
November 2018
4 Reads

Diagnostic histochemistry: A historical perspective.

Authors:
Mark R Wick

Semin Diagn Pathol 2018 Nov 16;35(6):354-359. Epub 2018 Oct 16.

Divisions of Surgical Pathology & Cytopathology and Autopsy Pathology, University of Virginia Medical Center, 1215 Lee St., Charlottesville, VA 22908-0214, USA. Electronic address:

Histochemistry has a history which, in some ways, goes back to ancient times. The desire for humans to understand the workings of their bodies, and the roles that various chemicals have in them, is long-standing. This review considers the evolution of histochemistry and cytochemistry as scientific disciplines, culminating in the pairing of those techniques with basic biochemistry. Read More

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November 2018
1 Read

Histochemistry in the diagnosis of non-neoplastic gastrointestinal disorders.

Semin Diagn Pathol 2018 Nov 16;35(6):370-380. Epub 2018 Oct 16.

Department of Pathology, St. Jude Medical Center, Fullerton, CA 92835, United States. Electronic address:

The alimentary tract serves as host to a large number of diseases. In the non-neoplastic group of disorders, conventional histochemistry continues to play an important diagnostic role. It is particularly important in recognizing specific infectious diseases, such as Helicobacter gastritis, Whipple disease, intestinal tuberculosis and other forms of mycobacteriosis, malakoplakia, intestinal spirochetosis, fungal enteritides, amebiasis, cryptosporidiosis, isosporiasis, and microsporidiosis. Read More

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http://dx.doi.org/10.1053/j.semdp.2018.10.002DOI Listing
November 2018
21 Reads

"What the world, social and political, concrete and mental, really needs is not new things, but the old things made new." Ethel M. Dell.

Authors:
Mark R Wick

Semin Diagn Pathol 2018 Nov 17;35(6):353. Epub 2018 Oct 17.

University of Virginia Medical Center, Charlottesville, VA. Electronic address:

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http://dx.doi.org/10.1053/j.semdp.2018.10.008DOI Listing
November 2018
2 Reads

Reprint of: The pathology of pulmonary sarcoidosis: update.

Semin Diagn Pathol 2018 Sep 24;35(5):324-333. Epub 2018 Sep 24.

Department of Lung Pathologist, KEck Medical Center of USC, Los Angeles, California. Electronic address:

Sarcoidosis is a multi-system disease of unknown etiology, usually affecting the respiratory tract and other organs, and is characterized by the formation of nonnecrotizing epithelioid granulomas. The diagnosis depends on a combination of a typical clinicoradiological presentation, the finding of nonnecrotizing epithelioid granulomas in a tissue biopsy, and exclusion of other possible diseases, especially those of infectious etiology. The granulomas contain epithelioid cells, giant cells, CD4+ T cells in their center, and CD8+ T lymphocytes and B lymphocytes at their periphery. Read More

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September 2018
5 Reads

Reprint of: Nonspecific interstitial pneumonia: pathologic features and clinical implications.

Authors:
Jeffrey L Myers

Semin Diagn Pathol 2018 Sep 8;35(5):334-338. Epub 2018 Sep 8.

Division of Anatomic Pathology, The University of Michigan, Ann Arbor, Michigan. Electronic address:

Nonspecific interstitial pneumonia (NSIP) is a form of chronic interstitial pneumonia that should be separated from the other idiopathic interstitial pneumonias, including most importantly, usual interstitial pneumonia (UIP). Diagnosis is predicated on identification of characteristic findings in a surgical lung biopsy in the appropriate clinical and radiological context. Affected patients may have a variety of underlying or associated conditions, although most have a form of idiopathic lung disease associated with a more favorable prognosis than UIP/idiopathic pulmonary fibrosis (IPF). Read More

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http://dx.doi.org/10.1053/j.semdp.2018.09.002DOI Listing
September 2018
1 Read

Reprint of: Unusual non-neoplastic lesions of the lung.

Semin Diagn Pathol 2018 Sep 8;35(5):339-346. Epub 2018 Sep 8.

Department of Pathology, Medical College of Wisconsin, Milwaukee, Wisconsin.

Many nonneoplastic conditions that may affect the lung are in reality rare or unusual manifestations of metabolic processes, inflammatory conditions, or unknown etiology. Because of their rarity, they can often be confused with malignant neoplasms. Familiarity with these conditions not only will expedite further treatment for these patients but also will avoid the process of more tests or unnecessary surgical procedures. Read More

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http://dx.doi.org/10.1053/j.semdp.2018.09.003DOI Listing
September 2018
1 Read

Reprint of: Pathologic manifestations of Immunoglobulin(Ig)G4-related lung disease.

Semin Diagn Pathol 2018 Sep 8;35(5):347-351. Epub 2018 Sep 8.

Department of Laboratory Medicine and Pathology, Mayo Clinic, Scottsdale, Arizona.

Immunoglobulin(Ig)G4-related disease (IgG4-RD) is a fibroinflammatory condition that can affect virtually any organ and usually presents as tumefactive lesions involving multiple sites. Characteristic histopathology of IgG4-RD consists of dense lymphoplasmacytic infiltrate, fibrosis (often in storiform pattern), and obliterative phlebitis, accompanied by tissue infiltration of IgG4-positive plasma cells with or without elevation of serum IgG4 level. Despite a general similarity in the morphologic manifestations of IgG4-RD, site-specific unique morphologic features have been described in some organs including the lung. Read More

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September 2018
17 Reads

Interstitial lung disease: Elementary lesions and diagnosis.

Semin Diagn Pathol 2018 Sep 13;35(5):288-296. Epub 2018 Aug 13.

Department of Pathology, Abderrahman Mami Hospital, Tunisia; Université Tunis El Manar, Faculté de Médecine de Tunis, Tunisia.

An effective approach to the diagnosis of interstitial lung diseases requires a standardized method of evaluation with a structured analysis, beginning with scanning microscopy and proceeding to a more detailed assessment. This article is structured around the histologic patterns defined by Leslie that facilitate this process. They include acute injury, fibrosis, cellular infiltrates, airspace filling, formation of nodules, and minimal changes. Read More

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http://dx.doi.org/10.1053/j.semdp.2018.08.001DOI Listing
September 2018
1 Read

Pulmonary disorders that are potentially associated with anti- neutrophilic cytoplasmic antibodies: A brief review.

Authors:
Mark R Wick

Semin Diagn Pathol 2018 Sep 24;35(5):304-314. Epub 2018 Aug 24.

Division of Surgical Pathology and Cytopathology, University of Virginia Medical Center, Charlottesville, VA, United States. Electronic address:

Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis frequently manifests with involvement of the lungs and kidneys, and it also may affect other anatomic sites. This article presents the patterns of pulmonary injury in which ANCA-associated vasculitis is included in the differential diagnosis, with a discussion of antineutrophil cytoplasmic antibody testing methods. The histologic features of non-vasculitic, potentially-ANCA-associated pulmonary lesions are reviewed briefly as well. Read More

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http://dx.doi.org/10.1053/j.semdp.2018.08.005DOI Listing
September 2018
5 Reads

Introduction.

Semin Diagn Pathol 2018 Sep 16;35(5):279. Epub 2018 Aug 16.

Department of Pathology, University of Virginia Medical Center, Charlottesville, VA, USA. Electronic address:

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September 2018
1 Read

The utility of bronchoalveolar lavage in the evaluation of interstitial lung diseases: A clinicopathological perspective.

Semin Diagn Pathol 2018 Sep 24;35(5):280-287. Epub 2018 Aug 24.

Department of Pathology, Abderrahman Mami Hospital, Ariana, Tunis, Tunisia; University Tunis El Manar, Tunis, Tunisia.

Bronchoalveolar lavage (BAL) is a noninvasive and well-tolerated procedure that is performed with a fiberoptic bronchoscope in the wedged position within a selected bronchopulmonary segment. After it was introduced to clinical practice, BAL rapidly gained acceptance in a large number of centers as a procedure that could be applied to the clinical evaluation of patients with various pulmonary disorders, especially the group of interstitial lung diseases (ILD). Cytological and flow cytometric analysis of BAL fluid in ILD is done with knowledge of the clinical presentation and radiological findings. Read More

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http://dx.doi.org/10.1053/j.semdp.2018.08.003DOI Listing
September 2018
5 Reads

Interstitial lung diseases: Imaging contribution to diagnosis and elementary radiological lesions.

Semin Diagn Pathol 2018 Sep 10;35(5):297-303. Epub 2018 Aug 10.

Imaging Department, Abderrahmen Mami Hospital, Ariana, Tunisia; Faculty of Medicine of Tunis, Tunis El Manar University, Tunisia.

Interstitial pneumonias comprise a heterogeneous group of disorders in which a multidisciplinary approach is important for accuracy in diagnosis; indeed, one might say, even mandatory. The team of collaborators should include radiologists, because high resolution computed tomography (HRCT) of the thorax is the first, and most of times, the only imaging examination to be prescribed after chest X-ray. Elementary lesions of the interstitium can be accurately described with HRCT, inasmuch as lung windowing with sharp filtering in this technique reproduces the microscopic features of the lung. Read More

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September 2018
5 Reads

Pathologic features of smoking-related lung diseases, with emphasis on smoking-related interstitial fibrosis and a consideration of differential diagnoses.

Authors:
Mark R Wick

Semin Diagn Pathol 2018 Sep 10;35(5):315-323. Epub 2018 Aug 10.

Division of Surgical Pathology & Cytopathology, University of Virginia Medical Center, Charlottesville, VA, USA. Electronic address:

Smoking-related interstitial fibrosis (SRIF) is frequently-seen and morphologically-distinctive finding in the lung tissue of cigarette smokers. It can be distinguished histologically from the idiopathic interstitial pneumonias and other causes of pulmonary interstitial fibrosis. SRIF is typified by dense thickening of the alveolar septa by thick collagen bundles with a hyalinized appearance, with the common admixture of bands of hyperplastic smooth muscle. Read More

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http://dx.doi.org/10.1053/j.semdp.2018.08.002DOI Listing
September 2018
2 Reads

Iatrogenic lesions-Preface.

Authors:
Mark R Wick

Semin Diagn Pathol 2018 Jul 19;35(4):207. Epub 2018 Apr 19.

University of Virginia Medical Center, University of Virginia Hospital Division of Surgical Pathology & Cytopathology, 2666 Coralberry Place, Charlottesville, VA 22911-8276, United States. Electronic address:

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http://dx.doi.org/10.1053/j.semdp.2018.04.001DOI Listing
July 2018
1 Read

Iatrogenic pulmonary lesions.

Semin Diagn Pathol 2018 Jul 23;35(4):260-271. Epub 2018 Mar 23.

Service de Pneumologie et Soins Intensifs Respiratoires, Hopital du Bocage Centre Hospitalier Universitaire (CHU) de Bourgogne, Dijon, France; UFR des Sciences de Santé, Université de Bourgogne, Dijon, France; INSERM U866, Faculté de Médecine, Dijon, France.

Treatment of patients often includes the administration of medications and sometimes radiation. While the intent is to treat an underlying condition, in some cases, adverse effects occur due to these agents. Most of these adverse effects are mild, however, some can be severe and life-threatening. Read More

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http://dx.doi.org/10.1053/j.semdp.2018.03.002DOI Listing
July 2018
19 Reads

Reexamining post-transplant lymphoproliferative disorders: Newly recognized and enigmatic types.

Semin Diagn Pathol 2018 Jul 3;35(4):236-246. Epub 2018 Mar 3.

University of Virginia Health System, 1215 Lee Street, Box 800214, Charlottesville, VA, United States.. Electronic address:

Post-transplant lymphoproliferative disorders (PTLD) are a known risk for both solid organ transplant and stem cell transplant recipients. Overall transplant recipients have a six fold increase in risk for developing any kind of non-Hodgkin lymphoma and PTLDs occur in up to 10% of SOT recipients. Several new entities have been accepted or renamed in the 2018 update of the WHO classification of tumors of hematopoietic and lymphoid neoplasms, including florid follicular hyperplasia and extranodal marginal zone lymphomas of mucosa-associated lymphoid tissue (MALT-lymphoma) (excluding common locations such as stomach and salivary gland). Read More

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http://dx.doi.org/10.1053/j.semdp.2018.02.001DOI Listing
July 2018
5 Reads

Iatrogenic pathology of the urinary bladder.

Semin Diagn Pathol 2018 Jul 14;35(4):218-227. Epub 2018 Mar 14.

Department of Pathology, University at Alabama Birmingham School of Medicine, Birmingham, AL, USA.

Intravesical immunotherapy, chemotherapy, and neoadjuvant systemic chemotherapy are among the most frequent therapeutic procedures to treat malignancies of the urinary bladder. These treatment modalities produce reactive morphologic changes in the urothelium that can mimic urothelial carcinoma in situ, urothelial dysplasia or true invasive urothelial neoplasia. Mitomycin C used after transurethral resection of bladder tumor to reduce recurrences, BCG intravesical immunotherapy to treat high risk non-muscle invasive bladder cancer and urothelial carcinoma in situ, and platinum-based systemic chemotherapy to improve post-cystectomy disease-specific survival some of the causes of therapy related atypia in urinary bladder. Read More

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July 2018
8 Reads

Morphological clues to the appropriate recognition of hereditary renal neoplasms.

Semin Diagn Pathol 2018 May 14;35(3):184-192. Epub 2018 Feb 14.

Department of Pathology and Laboratory Medicine, University of Tennessee Health Sciences, Memphis, USA; Department of Urology, University of Tennessee Health Sciences, Memphis, USA.

An important emerging role of the surgical pathologist besides the traditional tasks of establishment of the diagnosis and documentation of prognostic and predictive factors, is to recognize the possibility of a hereditary condition in cases where the histology is suggestive for a familial cancer syndrome. In recent years, the knowledge regarding all of the above roles, including the role of recognition of familial cancer, has particularly expanded in renal neoplasms with the close scrutiny to morphology, molecular correlates and clinical features of the different sub-types of renal cell carcinoma. Awareness of these clinically distinctive sub-types and their associated histologic clues will prompt the pathologist for further immunohistochemical or molecular work up, to look for clinical information to support the suspected diagnosis of familial cancer, to alert managing physician/s to look for stigmata of history of familial cancer, which will permit triaging patients and their families for appropriate genetic counseling. Read More

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http://dx.doi.org/10.1053/j.semdp.2018.01.005DOI Listing
May 2018
7 Reads

Pathologists - The watchpersons for hereditary tumor syndromes.

Semin Diagn Pathol 2018 May 31;35(3):153. Epub 2018 Jan 31.

Divisions of Surgical Pathology, Cytopathology, & Autopsy Pathology, University of Virginia Health System, Charlottesville, VA 22908-0214, USA.

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http://dx.doi.org/10.1053/j.semdp.2018.01.006DOI Listing
May 2018
5 Reads

Hereditary gastrointestinal carcinomas and their precursors: An algorithm for genetic testing.

Semin Diagn Pathol 2018 May 31;35(3):170-183. Epub 2018 Jan 31.

Department of Pathology, University Medical Center Utrecht, Utrecht (UMCU), The Netherlands. Electronic address:

Recognition of hereditary forms of gastrointestinal cancer is of great importance for patients and their families and pathologists play a crucial role in this. This review recapitulates the clinical, pathological and molecular aspects of Hereditary Diffuse Gastric Cancer and Gastric Adenocarcinoma and Proximal Polyposis of the Stomach, as well as hereditary colorectal cancer syndromes such as Lynch syndrome and gastrointestinal polyposis syndromes (including Familial Adenomatous Polyposis, Peutz-Jeghers syndrome and Juvenile Polyposis syndrome). Histopathological clues to recognize hereditary forms of gastrointestinal cancer and possible ancillary studies that can support an underlying syndrome and guide genetic testing are discussed. Read More

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http://dx.doi.org/10.1053/j.semdp.2018.01.004DOI Listing
May 2018
12 Reads

Hereditary SWI/SNF complex deficiency syndromes.

Semin Diagn Pathol 2018 May 1;35(3):193-198. Epub 2018 Feb 1.

Departments of Human Genetics, Medicine and Oncology, McGill University, Montreal, Quebec, Canada.

The SWItch Sucrose non-fermentable (SWI/SNF) complex is a highly conserved multi-subunit complex of proteins encoded by numerous genes mapped to different chromosomal regions. The complex regulates the process of chromatin remodelling and hence plays a central role in the epigenetic regulation of gene expression, cell proliferation and differentiation. During the last three decades, the SWI/SNF complex has been increasingly recognized as a central molecular event driving the initiation and/or progression of several benign and malignant neoplasms of different anatomic origin and having diverse histomorphological appearance. Read More

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http://dx.doi.org/10.1053/j.semdp.2018.01.002DOI Listing
May 2018
3 Reads

Uncovering Hereditary Tumor Syndromes: Emerging Role of Surgical Pathology.

Semin Diagn Pathol 2018 May 1;35(3):154-160. Epub 2018 Feb 1.

Institute of Pathology, Friedrich-Alexander-University Erlangen-Nürnberg, University Hospital, Erlangen, Germany.

With the increased use of modern next generation sequencing technologies in routine molecular pathology practice, the proportion of cancer cases with a definite or probable hereditary background seems to be steadily increasing. Currently, it is assumed that ≥10% of all malignancies develop in the setting of germline predisposition. Diagnosis and recognition of cancer predisposition syndromes relies not rarely on distinctive histopathological features that proved to be highly valuable and reproducible in uncovering those diseases that would otherwise have gone undetected by clinicians as being hereditary in nature. Read More

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http://dx.doi.org/10.1053/j.semdp.2018.01.001DOI Listing
May 2018
3 Reads

Drug induced pseudolymphoma.

Semin Diagn Pathol 2018 Jul 1;35(4):247-259. Epub 2018 Feb 1.

Regional Medical Laboratory, 4142 South Mingo Road, Tulsa, OK 74146-3632, United States.

Atypical lymphocytic infiltrates of the skin comprise a broad spectrum of entities ranging from benign infiltrates to those that are malignant. Many of these infiltrates are in fact reactive lymphomatoid ones related to drug therapy falling under the general category of drug associated pseudolymphoma. Within this nosologic umbrella are nodular and diffuse infiltrates resembling low grade T and B cell lymphoma consistent with lymphocytoma cutis, drug associated reversible T cell dyscrasias which draw a strong morphologic and phenotypic parallel with mycosis fungoides and the various pre-lymphomatous T cell dyscrasias, and angiocentric CD30 positive infiltrates mirroring lymphomatoid papulosis. Read More

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http://dx.doi.org/10.1053/j.semdp.2017.11.003DOI Listing
July 2018
10 Reads

Lymphadenopathies in human immunodeficiency virus infection.

Semin Diagn Pathol 2018 Jan 6;35(1):84-91. Epub 2017 Dec 6.

Department of Pathology, Instituto Nacional de Enfermedades Neoplásicas, Av. Angamos Este 2520, Lima 34, Peru.

This article describes the various non-neoplastic lymphadenopathies that occur in patients infected with the human immunodeficiency virus (HIV), before or during the stage of acquired immunodeficiency syndrome (AIDS). The stages that develop during the HIV infection include: primary infection (acute infection, spread of the virus, development of host immune response, and acute retroviral syndrome), chronic infection or clinical latency, and finally, the AIDS stage. Non-neoplastic lymphadenopathies can occur at any of these phases of the infection and are due to multiple causes that can be divided into infectious causes (bacterial, fungal, parasitic, viral), and reactive causes (persistent generalized lymphadenopathy and a variety of situations that they also occur in immunocompetent people such as Castleman's disease and Kikuchi-Fujimoto's disease, among others). Read More

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http://dx.doi.org/10.1053/j.semdp.2017.12.001DOI Listing
January 2018
5 Reads

Re-Defining 'Reactive' lymphadenopathies: How molecular lessons have changed our minds.

Semin Diagn Pathol 2018 Jan 6;35(1):1-3. Epub 2017 Dec 6.

Associate Medical Chief, Pathology Service, Fundación Jiménez Díaz, Av Reyes Católicos, 2, 28040 Madrid, Spain. Electronic address:

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http://dx.doi.org/10.1053/j.semdp.2017.12.002DOI Listing
January 2018
4 Reads

A guided tour of selected issues pertaining to metastatic carcinomas involving or originating from the gynecologic tract.

Semin Diagn Pathol 2018 Mar 20;35(2):95-107. Epub 2017 Nov 20.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, United States.

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https://linkinghub.elsevier.com/retrieve/pii/S07402570173013
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http://dx.doi.org/10.1053/j.semdp.2017.11.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5821534PMC
March 2018
11 Reads

Immunohistochemistry, carcinomas of unknown primary, and incidence rates.

Semin Diagn Pathol 2018 Mar 23;35(2):143-152. Epub 2017 Nov 23.

Vitro Molecular Laboratories, Miami, FL, United States.

Pathologists use immunohistochemistry is their day-to-day practices to assist in distinguishing site of origin of metastatic carcinomas. Here, the work-up is discussed neuroendocrine carcinomas, squamous cell carcinomas and adenocarcinomas with particular attention to tumor incident rates and predictive values of the best-performing immunohistochemical markers. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07402570173013
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http://dx.doi.org/10.1053/j.semdp.2017.11.012DOI Listing
March 2018
7 Reads

Castleman Disease and Rosai-Dorfman Disease.

Semin Diagn Pathol 2018 Jan 2;35(1):44-53. Epub 2017 Dec 2.

Pathology Service, Hospital Universitario Marques de Valdecilla, Santander, Spain.

This chapter describes the main features of two different diseases, Castleman Disease (CD) and Rosai-Dorfman Disease (RDD). Castleman disease (CD) is a clinical and histopathologically heterogeneous lymphoproliferative disorder that encompasses at least three distinct entities with some common overlapping morphological features: Hyaline Vascular CD (HVCD), Unicentric Plasma Cell CD and Multicentric CD. The most important feature of HVCD is the presence of abnormal germinal centers with hyaline-vascular transformation, sometimes showing multiple germinal centers within a single reactive lymphoid follicle, this outlining HVCD as a disorder of follicular dendritic cells. Read More

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http://dx.doi.org/10.1053/j.semdp.2017.11.014DOI Listing
January 2018
12 Reads

Autoimmune and medication-induced lymphadenopathies.

Semin Diagn Pathol 2018 Jan 28;35(1):34-43. Epub 2017 Nov 28.

Neogenomics, Aliso Viejo, CA, USA.

This article will provide a discussion of some common autoimmune disorders that could affect the lymph nodes and potentially mimic B and T-cell lymphomas. Some of these disorders are more characteristic of individuals in the pediatric age group (autoimmune lymphoproliferative syndrome, Kawasaki disease), while others present in older individuals (rheumatoid arthritis, lupus erythematosus, sarcoidosis). A common finding that groups all of these disorders together is the overall relative preservation of the architecture, a feature that can be particularly helpful to distinguish them from many B and T-cell lymphomas. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07402570173014
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http://dx.doi.org/10.1053/j.semdp.2017.11.015DOI Listing
January 2018
9 Reads

Diagnosis and management of metastatic neoplasms with unknown primary.

Semin Diagn Pathol 2018 May 26;35(3):199-206. Epub 2017 Nov 26.

Clinical Cooperation Unit Molecular Hematology / Oncology, German Cancer Research Center (DKFZ) and Department of Medicine V, University of Heidelberg, Heidelberg, Germany; Department of Internal Medicine V, Hematology / Oncology, University of Heidelberg, Heidelberg, Germany. Electronic address:

In cancer of unknown primary (CUP), metastases are clinically and histologically confirmed, but the primary tumor site remains elusive after extensive work-up. CUPs make up for 2-3% of all epithelial malignancies. The two prevailing histologies are adenocarcinomas and undifferentiated carcinomas, whereas squamous cell carcinomas, neuroendocrine carcinomas and rare histologies account for the remaining 10%. Read More

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http://dx.doi.org/10.1053/j.semdp.2017.11.013DOI Listing
May 2018
8 Reads

Preface.

Authors:
Mark R Wick

Semin Diagn Pathol 2018 Mar 22;35(2):93-94. Epub 2017 Nov 22.

2666 Coralberry Place Charlottesville, VA 22911-8276, United States. Electronic address:

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http://dx.doi.org/10.1053/j.semdp.2017.11.011DOI Listing
March 2018
7 Reads

Metastases of malignant neoplasms: Historical, biological, & clinical considerations.

Authors:
Mark R Wick

Semin Diagn Pathol 2018 Mar 24;35(2):112-122. Epub 2017 Nov 24.

Division of Surgical Pathology & Cytopathology, Department of Pathology, University of Virginia Medical Center, Room 3020, 1215 Lee Street, Charlottesville, VA 22908-0214, United States. Electronic address:

The metastasis of neoplastic cells from their site of origin to distant anatomic locations continues to be the principal cause of death from malignant tumors, and that fact has been recognized by physicians for over a century. After the work done by Halsted in the treatment of breast cancer in the 1880s, accepted surgical canon held that metastasis occurred in a linear fashion, with centrifugal "growth in continuity" from the primary neoplasm that first involved regional lymph nodes. Those structures were considered to then be the sources of more distant, visceral metastases. Read More

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http://dx.doi.org/10.1053/j.semdp.2017.11.009DOI Listing
March 2018
3 Reads

Primary lesions that may imitate metastatic tumors histologically: A selective review.

Authors:
Mark R Wick

Semin Diagn Pathol 2018 Mar 17;35(2):123-142. Epub 2017 Nov 17.

Division of Surgical Pathology & Cytopathology, University of Virginia Medical Center, Room 3020, 1215 Lee St., Charlottesville, VA 22908-0214, USA. Electronic address:

Several primary pathologic entities in diverse anatomic locations have the potential to simulate metastatic neoplasms histologically. Their misinterpretation as such may result in needless and extensive clinical evaluations that are intended to detect a presumed malignancy at another site. More importantly, mistakes of this type can deprive patients of surgical excisions that could be curative. Read More

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http://dx.doi.org/10.1053/j.semdp.2017.11.010DOI Listing
March 2018
26 Reads

Surviving at a distant site: The organotropism of metastatic breast cancer.

Semin Diagn Pathol 2018 Mar 16;35(2):108-111. Epub 2017 Nov 16.

Department of Pathology, School of Medicine, the University of Alabama at Birmingham, Birmingham, AL, USA.

Many cancers demonstrate a non-random distribution of sites for distant relapse while others have the propensity to metastasize to multiple organ systems. One of the notable recent findings is that the breast cancer subtypes differ not only in their biological characteristics as primary tumors but also in their capacity for metastatic progression. This information could potentially be utilized in treatment decision making and surveillance strategies. Read More

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http://dx.doi.org/10.1053/j.semdp.2017.11.008DOI Listing
March 2018
4 Reads

Epstein-Barr Virus (EBV) associated reactive and indeterminate lymphoid proliferations in the lymph node.

Semin Diagn Pathol 2018 Jan 15;35(1):54-60. Epub 2017 Nov 15.

The Joint Pathology Center, 606 Stephen Sitter Lane, Silver Spring, MD 20910, United States.

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http://dx.doi.org/10.1053/j.semdp.2017.11.005DOI Listing
January 2018
8 Reads

Lymph node stromal and vascular proliferations.

Semin Diagn Pathol 2018 Jan 15;35(1):67-75. Epub 2017 Nov 15.

Neogenomics, Aliso Viejo, CA, United States.

The recognition and reporting of stromal and vascular lesions of the lymph node is rife with difficulties including relative rarity, a lack of familiarity with lesions and the challenges of using ancillary studies appropriately. In this manuscript, we highlight a range of benign stromal and vascular abnormalities that can be identified in nodal specimens. Read More

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http://dx.doi.org/10.1053/j.semdp.2017.11.004DOI Listing
January 2018
6 Reads