1,008 results match your criteria Seminars in Reproductive Medicine [Journal]


Impact of Deployment on Reproductive Health in U.S. Active-Duty Servicewomen and Veterans.

Semin Reprod Med 2018 Nov 19;36(6):361-370. Epub 2019 Apr 19.

Informatics, Decision Enhancement, and Analytic Sciences (IDEAS) Center, VA Salt Lake City Health Care System, Salt Lake City, Utah.

Reproductive-age women are a fast-growing component of active-duty military personnel who experience deployment and combat more frequently than previous service-era women Veterans. With the expansion of the number of women and their roles, the United States Departments of Defense and Veterans Affairs have prioritized development and integration of reproductive services into their health systems. Thus, understanding associations between deployments or combat exposures and short- or long-term adverse reproductive health outcomes is imperative for policy and programmatic development. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0039-1678749
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http://dx.doi.org/10.1055/s-0039-1678749DOI Listing
November 2018
5 Reads

The Department of Defense Birth and Infant Health Research Program: Assessing the Reproductive Health of U.S. Active-Duty Women.

Semin Reprod Med 2018 Nov 19;36(6):351-360. Epub 2019 Apr 19.

The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland.

As the percentage of women serving in the active-duty military continues to grow, and as their roles continue to expand, the importance of monitoring reproductive health in the military community increases. The Department of Defense Birth and Infant Health Research (BIHR) program conducts ongoing epidemiologic studies to assess potential increased risks for adverse reproductive and infant health outcomes in the military population. Military personnel endure unique physical and mental demands as a part of their occupational duties (e. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0039-1678751
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http://dx.doi.org/10.1055/s-0039-1678751DOI Listing
November 2018
1 Read

The Gynecologic Health Consequences of Chlamydia trachomatis Infection in Military Servicewomen.

Semin Reprod Med 2018 Nov 19;36(6):340-350. Epub 2019 Apr 19.

Department of Clinical Investigation, Madigan Army Medical Center, Tacoma, Washington.

is the most common sexually transmitted bacterial infection in the United States. Within the U.S. Read More

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November 2018
5 Reads

Preconception Care in the Veterans Health Administration.

Semin Reprod Med 2018 Nov 19;36(6):327-339. Epub 2019 Apr 19.

VA Central Office, Women's Health Services, Washington, District of Columbia.

Preconception care (PCC), defined as a set of interventions to help women optimize their health and well-being prior to pregnancy, can improve pregnancy outcomes and is recommended by national organizations including the Centers for Disease Control and Prevention and the American College of Obstetricians and Gynecologists. Women Veterans who use the Department of Veterans Affairs (VA) health care system may face elevated risks of adverse pregnancy and birth outcomes due to a high prevalence of chronic medical and mental health conditions as well as psychosocial stressors including sexual trauma history and intimate partner violence. Many women Veterans of childbearing age experience poverty and homelessness, which are key social determinants of poor reproductive health outcomes. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0039-1678753
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November 2018
1 Read

Assisted Reproductive Technology and the Reproductive Endocrinology and Infertility Specialist in the U.S. Military.

Semin Reprod Med 2018 Nov 19;36(6):323-326. Epub 2019 Apr 19.

Walter Reed National Military Medical Center, Bethesda, Maryland.

The U.S. military mirrors the U. Read More

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http://dx.doi.org/10.1055/s-0039-1681084DOI Listing
November 2018

Reproductive Health of Women Veterans: A Systematic Review of the Literature from 2008 to 2017.

Semin Reprod Med 2018 Nov 19;36(6):315-322. Epub 2019 Apr 19.

Division of Gynecology, Department of Surgery, VA Boston Healthcare System, Boston, Massachusetts.

The literature on the reproductive health and healthcare of women Veterans has increased dramatically, though there are important gaps. This article aims to synthesize recent literature on reproductive health and healthcare of women Veterans. We updated a literature search to identify manuscripts published between 2008 and July 1, 2017. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0039-1678750
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November 2018
1 Read

Reproductive Health Needs of the Military and Veterans: Part 1.

Semin Reprod Med 2018 Nov 19;36(6):313-314. Epub 2019 Apr 19.

Department of Obstetrics and Gynecology, Uniformed Services University of the Health Sciences, Bethesda, Maryland.

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http://dx.doi.org/10.1055/s-0039-1683423DOI Listing
November 2018

Alicia Y. Christy, MD, MHSCR, FACOG and Richard Burney, MD, MSc.

Authors:
James H Segars

Semin Reprod Med 2018 Nov 19;36(6):311-312. Epub 2019 Apr 19.

Division of Reproductive Sciences and Women's Health Research, Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, Maryland.

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http://dx.doi.org/10.1055/s-0039-1683914DOI Listing
November 2018

Legal Issues in Gamete and Embryo Cryopreservation: An Overview.

Semin Reprod Med 2018 Sep 4;36(5):299-310. Epub 2019 Apr 4.

Georgetown Law, Washington, District of Columbia.

This article provides an overview of existing and developing law surrounding IVF embryos and those who handle them. It discusses what law and legal theories of liability may apply to embryology labs, and gamete and embryo banks in the context of embryo loss, abandonment, shipping and implantation. It explores how often intertwined theories of law have been applied to this unique field, including contract, informed consent, health, tort and Constitutional law. Read More

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http://dx.doi.org/10.1055/s-0038-1676852DOI Listing
September 2018
1 Read

Safe Storage of Gametes and Embryos: No Time for Complacency.

Semin Reprod Med 2018 Sep 4;36(5):289-298. Epub 2019 Apr 4.

Fertility Unit, Nottingham University Hospital, Nottingham, United Kingdom.

Recent serious untoward incidents in the field of assisted reproduction have once again highlighted the need for vigilance and in particular improved risk management in relation to the cryopreservation of gametes and embryos. Despite increasing levels of regulation and the requirement to adhere to total quality management practices, catastrophic incidents such as the death of an employee or the loss of a freezer full of patient embryos or sperm continue to occur sufficiently frequently for the industry to be concerned and highlight the need to make practices considerably safer. Potential losses through litigation could be considerable if the gamete or embryo bank is found to be negligent and fails to provide the necessary resources and implement recognizable control measures, which may include suitable facilities with adequate ventilation and oxygen monitoring, competent staff, and an appropriate level of well-maintained equipment; round-the-clock emergency procedures, early warning systems to deal with a failing vessel; and contingency to mitigate losses within a failing vessel and validated procedures which are embedded into the organization which lead to a high-quality end product, for example, frozen embryo while permitting a safe system of work. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0039-1678596
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September 2018
2 Reads

Reproductive Tissue Storage: Quality Control and Management/Inventory Software.

Semin Reprod Med 2018 Sep 4;36(5):280-288. Epub 2019 Apr 4.

Mellowood Medical, Inc., Toronto, Ontario, Canada.

The recent failure of two liquid nitrogen storage tanks at two separate facilities in the United States has highlighted the need to reexamine our approach to how reproductive laboratories handle the storage of tissue. If we wish to truly understand how we can increase the security and safety of stored reproductive tissue, we really need to understand how often these events (tank failure) occur and what are the ultimate causes of these failures. Are there design flaws in the storage tanks or are these really failures in protocols and following protocols? Unfortunately, because these cases often involve serious litigation, most do not want to or are forbidden to talk about these failures and so we have little data to base recommendations on. Read More

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http://dx.doi.org/10.1055/s-0038-1676851DOI Listing
September 2018
1 Read

Life Interrupted: The Nature and Consequences of Cryostasis.

Authors:
Henry Malter

Semin Reprod Med 2018 Sep 4;36(5):273-279. Epub 2019 Apr 4.

Director of Laboratories, Fertility Center of the Carolinas, University of South Carolina School of Medicine, Greenville South Carolina.

Cryopreservation and associated cryostorage has become a well-established technique in both basic and clinical science. When the potentially lethal consequences of freezing itself are ameliorated, existence at cryogenic temperatures seems to be a form of true viable stasis that can persist for long periods of time. Natural cryopreservation and revival after long-term periods in cryostasis is reality in many species. Read More

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http://dx.doi.org/10.1055/s-0038-1676850DOI Listing
September 2018

Human Reproductive Cell Cryopreservation, Storage, Handling, and Transport: Risks and Risk Management.

Semin Reprod Med 2018 Sep 4;36(5):265-272. Epub 2019 Apr 4.

Reproductive Medicine Unit, GynePro Medical Centers, Bologna, Italy.

Millions of human oocytes and embryos are stored in thousands of locations across the globe. This inventory continues to grow as cryopreservation becomes more successful and more widely applied. The results of studies assessing pregnancy and neonatal outcomes following frozen embryo transfer (FET) have been encouraging, showing lower incidences of small for gestational age neonates and preterm birth compared with fresh transfers. Read More

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http://dx.doi.org/10.1055/s-0038-1676849DOI Listing
September 2018
3 Reads

Perspectives in Gamete and Embryo Cryopreservation.

Semin Reprod Med 2018 Sep 4;36(5):253-264. Epub 2019 Apr 4.

Cryopreserved gametes and embryos are a major feature of human-assisted reproduction and patient care services, accounting for an increasing number of births worldwide. Since the first success obtained using frozen human spermatozoa, cryopreservation technology has been successfully extended to include oocytes and embryos, in a variety of both medical and nonmedical indications. Over the years, the available procedures have become widely implemented and the increasing evidence of its efficacy has contributed to acceptance of the technology. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0038-1677463
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September 2018
10 Reads

Gamete and Embryo Storage.

Authors:
Jacques Cohen

Semin Reprod Med 2018 09 4;36(5):251-252. Epub 2019 Apr 4.

The Art Institute of Washington, Arlington, Virginia.

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http://dx.doi.org/10.1055/s-0039-1678597DOI Listing
September 2018

Jacques Cohen, PhD.

Authors:
James H Segars

Semin Reprod Med 2018 Sep 4;36(5):249-250. Epub 2019 Apr 4.

Division of Reproductive Sciences and Women's Health Research, Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, Maryland.

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http://dx.doi.org/10.1055/s-0039-1678595DOI Listing
September 2018

Assisted Reproductive Technologies and the Placenta: Clinical, Morphological, and Molecular Outcomes.

Semin Reprod Med 2018 05 13;36(3-04):240-248. Epub 2019 Mar 13.

Department of Cell and Developmental Biology, Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

As the biological bridge between mother and fetus, the placenta is not only important for the health of the mother and fetus during pregnancy but it also impacts the lifelong health of the fetus. Assisted reproductive technologies (ARTs) involve procedures and exposures that are not characteristic of in vivo reproduction. Moreover, ART procedures occur when the gametes and embryos are undergoing extensive epigenetic reprogramming. Read More

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http://dx.doi.org/10.1055/s-0038-1676640DOI Listing

Sperm Epigenetics and Its Impact on Male Fertility, Pregnancy Loss, and Somatic Health of Future Offsprings.

Semin Reprod Med 2018 05 13;36(3-04):233-239. Epub 2019 Mar 13.

Department of Obstetrics and Gynecology, Utah Center for Reproductive Medicine, University of Utah School of Medicine, Salt Lake City, Utah.

Sperm epigenetic programming is tailored to meet the need of this specialized cell, which include its interaction with the oocyte during fertilization and early embryo development. The unique nature of the sperm epigenome has resulted in multiple studies investigating how perturbations in epigenetics might impact male fertility and early embryo development. In addition, sperm epigenetics appear to be altered by specific environmental exposures, which could provide a link for investigating the role of these triggers in somatic health of off springs produced. Read More

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http://dx.doi.org/10.1055/s-0038-1677047DOI Listing
May 2018
1 Read

Assisted Reproductive Technology and Epigenetics.

Semin Reprod Med 2018 05 13;36(3-04):221-232. Epub 2019 Mar 13.

Colorado Center for Reproductive Medicine Northern Virginia, Vienna, Virginia.

Assisted reproductive technology (ART) is responsible for 1.7% of births in the United States annually. Despite a large number of studies promoting the efficacy and safety of these practices, there have been reports of imprinting disorders occurring at higher frequencies in children born through ART. Read More

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http://dx.doi.org/10.1055/s-0038-1675780DOI Listing
May 2018
2 Reads

Embryo Culture Conditions and the Epigenome.

Semin Reprod Med 2018 05 13;36(3-04):211-220. Epub 2019 Mar 13.

Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, Pennsylvania.

Assisted reproductive technologies (ARTs) lead to an increased risk for pregnancy complications, congenital abnormalities, and specific imprinting disorders. Epigenetic dysfunction is thought to be one common mechanism which may be affecting these outcomes. The timing of multiple ART interventions overlaps with developmental time periods that are particularly vulnerable to epigenetic change. Read More

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http://dx.doi.org/10.1055/s-0038-1675777DOI Listing
May 2018
2 Reads

Transitioning from Infertility-Based (ART 1.0) to Elective (ART 2.0) Use of Assisted Reproductive Technologies and the DOHaD Hypothesis: Do We Need to Change Consenting?

Semin Reprod Med 2018 05 13;36(3-04):204-210. Epub 2019 Mar 13.

Division or Reproductive Endocrinology, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco, San Francisco, California.

The use of assisted reproductive technologies (ARTs) has increased significantly in recent years. While this is partially due to improved access for infertile patients, another contribution to the growth of ART utilization is represented by individuals without infertility, who electively chose to freeze their gametes and embryos for future use, before ever attempting conception spontaneously. Overall, the safety of ART for parents and children is well described and the risks are modest. Read More

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http://dx.doi.org/10.1055/s-0038-1677526DOI Listing
May 2018
2 Reads

Assisted Reproductive Technology and Origins of Disease: The Clinical Realities and Implications.

Semin Reprod Med 2018 05 13;36(3-04):195-203. Epub 2019 Mar 13.

Reproductive Medicine Associates of New Jersey, Basking Ridge, New Jersey.

The majority of offspring born following assisted reproductive technology (ART) achieve equivalent development milestones and demonstrate comparable health as spontaneously conceived children. Yet, multiple studies have suggested offspring conceived with ART have slightly increased risk of metabolic derangements, cardiovascular disease, and malignancy. However, the associations observed in these studies often inadequately control for a variety of confounding variables, such as multiple gestation, premature birth, and low birth weight. Read More

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http://dx.doi.org/10.1055/s-0038-1677048DOI Listing
May 2018
3 Reads

Child Health: Is It Really Assisted Reproductive Technology that We Need to Be Concerned About?

Semin Reprod Med 2018 05 13;36(3-04):183-194. Epub 2019 Mar 13.

Department of Pediatrics, New York University School of Medicine, New York.

Concerns remain about the health of children conceived by infertility treatment. Studies to date have predominantly not identified substantial long-term health effects after accounting for plurality, which is reassuring given the increasing numbers of children conceived by infertility treatment worldwide. However, as technological advances in treatment arise, ongoing studies remain critical for monitoring health effects. Read More

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May 2018
6 Reads

Developmental Origins of Health and Disease: The History of the Barker Hypothesis and Assisted Reproductive Technology.

Semin Reprod Med 2018 05 13;36(3-04):177-182. Epub 2019 Mar 13.

Program in Reproductive Endocrinology and Gynecology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland.

Since Barker's publication of "The fetal and infant origins of adult disease" in 1990, significant emphasis has been placed on the intrauterine environment and its effect on adult disease. Historical events such as the Dutch Famine and the 1918 Flu Pandemic have provided organic data about the epigenetic changes that can result from famine, infection, and stress. Mechanisms that allow for intrauterine survival may predispose to adult disease states when the fetus enters a world of abundance. Read More

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May 2018
6 Reads

Assisted Reproductive Technologies and the Developmental Origins of Human Health and Disease.

Authors:
Micah J Hill

Semin Reprod Med 2018 05 13;36(3-04):175-176. Epub 2019 Mar 13.

Walter Reed National Military Medical Center, Bethesda, Maryland.

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http://dx.doi.org/10.1055/s-0039-1683393DOI Listing

Assisted Reproductive Technologies and the Developmental Origins of Health and Disease.

Authors:
James H Segars

Semin Reprod Med 2018 05 13;36(3-04):173-174. Epub 2019 Mar 13.

Division of Reproductive Sciences and Women's Health Research, Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, Maryland.

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http://dx.doi.org/10.1055/s-0038-1676641DOI Listing
May 2018
1 Read

The Neuroanatomy of Reproduction: Seeing Is Believing.

Semin Reprod Med 2019 Jan 3. Epub 2019 Jan 3.

Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Florida, Gainesville, Florida.

The brain is the central controller of reproduction and the menstrual cycle. Reproductive endocrinologists spend their days treating patients with perturbations in reproduction as a result of pituitary diseases and manipulate pituitary hormones to enhance fertility and quality of life. Microscopic neuroanatomical images will allow a better understanding of how a tumor in the pituitary might affect vision, or a mass in the brain might cause amenorrhea. Read More

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http://dx.doi.org/10.1055/s-0038-1675585DOI Listing
January 2019
2 Reads

Opioids and Alternatives in Female Chronic Pelvic Pain.

Semin Reprod Med 2018 Mar 19;36(2):164-172. Epub 2018 Dec 19.

Division of Minimally Invasive Gynecologic Surgery, Department of Obstetrics and Gynecology, Penn State Hershey Medical Center, 500 University Dr, Hershey, Pennsylvania.

Chronic pelvic pain is a complex condition with peripheral and central mechanisms of pain. Successful nonsurgical management typically relies on a multimodal approach, with integration of both pharmacologic and nonpharmacologic interventions. This article reviews nonpharmacologic therapies including pelvic floor physical therapy, dietary modifications, psychotherapy, and acupuncture. Read More

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http://dx.doi.org/10.1055/s-0038-1676102DOI Listing
March 2018
4 Reads

Interventional Pain Management and Female Pelvic Pain: Considerations for Diagnosis and Treatment.

Semin Reprod Med 2018 Mar 19;36(2):159-163. Epub 2018 Dec 19.

Division of Pain Medicine, Department of Anesthesiology and Perioperative Medicine, Penn State Milton S. Hershey Medical Center, Hershey, Pennsylvania.

Chronic pelvic pain (CPP) is a recurring and/or constant pain of at least six months duration that has resulted in either functional or psychological disability that can require interventional treatments. Chronic pelvic pain can be visceral, somatic, neuropathic, or a combination. Patients with CPP often suffer from concurrent bowel or bladder dysfunction, sexual dysfunction, depression, and anxiety. Read More

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http://dx.doi.org/10.1055/s-0038-1676104DOI Listing
March 2018
4 Reads

Female Sexual Dysfunction in Women with Pelvic Pain.

Semin Reprod Med 2018 Mar 19;36(2):152-158. Epub 2018 Dec 19.

Department of Obstetrics and Gynecology, Advocate Aurora Health Illinois Masonic Medical Center, Chicago, Illinois.

A variety of conditions can give rise to the perception of painful sexual intercourse in women with pelvic pain. Female sexual dysfunction may stem from psychological, medical such as endocrinological disturbances, and gynecological pathologies. This article provides a discussion of various conditions, offering diagnostic and therapeutic measures to consider in women with pelvic pain experiencing sexual dysfunction. Read More

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http://dx.doi.org/10.1055/s-0038-1676115DOI Listing
March 2018
2 Reads

Endometriosis and Female Pelvic Pain.

Semin Reprod Med 2018 Mar 19;36(2):143-151. Epub 2018 Dec 19.

Department of Obstetrics and Gynecology, Columbia University Medical Center, New York, New York.

Endometriosis is a nonmalignant gynecologic disorder that can have a significant impact on a woman's quality of life with pelvic pain and possible lasting effects on one's fertility. Symptoms, when present, can be severe and affect many organ systems including the gastrointestinal and urinary systems. Other etiologies of pelvic pain must be ruled out and/or need to be addressed concurrently for optimal patient care. Read More

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http://dx.doi.org/10.1055/s-0038-1676103DOI Listing
March 2018
4 Reads

Fibromyalgia and Irritable Bowel Syndrome in Female Pelvic Pain.

Semin Reprod Med 2018 Mar 19;36(2):136-142. Epub 2018 Dec 19.

Division of Minimally Invasive Gynecologic Surgery, Department of Obstetrics and Gynecology, Christiana Care Health System, Newark, Delaware.

Fibromyalgia and irritable bowel syndrome are common disorders which often coexist in women with chronic pelvic pain. Like pelvic pain, these disorders describe symptoms without pathologic findings. Women with chronic pelvic pain have a higher prevalence of fibromyalgia (4-31%) and irritable bowel syndrome (8-41%) than the general population. Read More

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http://dx.doi.org/10.1055/s-0038-1676090DOI Listing
March 2018
11 Reads

Interstitial Cystitis/Bladder Pain Syndrome.

Semin Reprod Med 2018 Mar 19;36(2):123-135. Epub 2018 Dec 19.

Department of Obstetrics and Gynecology, Pritzker School of Medicine, University of Chicago, Evanston, Illinois.

Interstitial cystitis/bladder pain syndrome is an uncommon but potentially devastating pelvic pain disorder affecting both women and men. This condition is often confusable and comorbid with other pelvic pain disorders. Although our understanding of the underlying pathophysiology is growing, the exact longitudinal course by which peripheral and central aberrations involving the bladder mucosa, peripheral inflammation, and central dysregulation of bladder sensitivity create painful bladder symptoms remains an area in need of further study. Read More

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http://dx.doi.org/10.1055/s-0038-1676089DOI Listing
March 2018
6 Reads

Pelvic Pain in Adolescents.

Semin Reprod Med 2018 Mar 19;36(2):116-122. Epub 2018 Dec 19.

Department of Obstetrics and Gynecology, University of Michigan Health System, Ann Arbor, Michigan.

Dysmenorrhea and noncyclic pelvic pain (chronic pelvic pain) are common in adolescents. The evaluation of teens with dysmenorrhea or chronic pelvic pain is aimed to diagnose possible gynecologic conditions (endometriosis, pelvic inflammatory disease, ovarian cysts, and obstruction of the reproductive tract) and nongynecologic conditions (irritable bowel syndrome, interstitial cystitis, and myofascial pain). The management of chronic pelvic pain in adolescents is often more complex than in adult women because both the adolescent and her parents are counseled and addressed, and her long-term emotional and physical health, fertility, and sexuality are considered. Read More

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March 2018
5 Reads

Musculoskeletal Considerations in Female Patients with Chronic Pelvic Pain.

Semin Reprod Med 2018 Mar 19;36(2):107-115. Epub 2018 Dec 19.

Department of Physical Therapy, University of Florida, Gainesville, Florida.

Persistent pelvic pain conditions are common and affect nearly 25% of the female U.S. population. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0038-1676085
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http://dx.doi.org/10.1055/s-0038-1676085DOI Listing
March 2018
17 Reads

Evaluation of Female Pelvic Pain.

Semin Reprod Med 2018 Mar 19;36(2):99-106. Epub 2018 Dec 19.

Section of Gynecology, Department of Surgery, Virginia Mason Medical Center, Seattle, Washington.

Chronic pelvic pain is a condition defined by pelvic pain for more than six months which is severe enough to cause functional disability or require treatment. When pain becomes a chronic condition, it is more challenging to evaluate and treat. Chronic pelvic pain patients often have multiple factors contributing to their pain. Read More

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http://dx.doi.org/10.1055/s-0038-1676084DOI Listing
March 2018
2 Reads

Female Pelvic Pain.

Authors:
Gerald J Harkins

Semin Reprod Med 2018 Mar 19;36(2):97-98. Epub 2018 Dec 19.

Department of Obstetrics and Gynecology, Penn State Hershey Medical Center, Hershey Pennsylvania.

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http://dx.doi.org/10.1055/s-0038-1676086DOI Listing
March 2018
2 Reads

Gerald J. Harkins, MD, MPT, FACOG.

Authors:
Richard S Legro

Semin Reprod Med 2018 03 19;36(2):95-96. Epub 2018 Dec 19.

Department of Obstetrics and Gynecology, Penn State College of Medicine, Hershey, Pennsylvania.

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http://dx.doi.org/10.1055/s-0038-1676367DOI Listing
March 2018
1 Read

Integrated Model of Care for Polycystic Ovary Syndrome.

Semin Reprod Med 2018 01 6;36(1):86-94. Epub 2018 Sep 6.

Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Victoria, Australia.

Polycystic ovary syndrome (PCOS) affects approximately one in seven women worldwide from early adulthood with heterogeneity in their healthcare needs through the life cycle. PCOS is challenging to diagnose and manage, with one-third of women reporting at least a 2-year delay in diagnosis. Current clinical services do not satisfactorily educate and support women with their diverse reproductive, metabolic, and psychological care needs with fragmentation of services across health providers. Read More

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http://dx.doi.org/10.1055/s-0038-1667310DOI Listing
January 2018
4 Reads

Informing Translation: The Accuracy of Information on Websites for Lifestyle Management of Polycystic Ovary Syndrome.

Semin Reprod Med 2018 01 6;36(1):80-85. Epub 2018 Sep 6.

Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Clayton, Victoria, Australia.

Lifestyle (diet, physical activity [PA], and/or behavioral) interventions are recommended for all women with polycystic ovary syndrome (PCOS) in international guidelines. The internet is a widely used health information resource. However, the accuracy of lifestyle information on PCOS websites is unknown and is reviewed here to inform translation of the international guideline on PCOS. Read More

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http://dx.doi.org/10.1055/s-0038-1667309DOI Listing
January 2018
1 Read

A Governance Model Addressing the Challenges of Contemporary Research.

Semin Reprod Med 2018 01 6;36(1):73-79. Epub 2018 Sep 6.

Robinson Research Institute, University of Adelaide and Fertility SA, Adelaide, South Australia, Australia.

In this paper, we describe the robust governance structures and processes underpinning the development of the first (2018). The guideline was an outcome of the Centre of Research Excellence for Polycystic Ovary Syndrome, and an example of a transformative, strategic research initiative to impact delivery model. The governance structure supported and delivered critical ethical and regulatory outcomes, including: broad and diverse representation across health professional and consumer groups and exceeded regulatory standards; adherence to rigorous knowledge creation processes; and compliance with the standards for guidelines set by the approval body, the Australian National Health and Medical Research Council (NHMRC). Read More

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http://dx.doi.org/10.1055/s-0038-1667157DOI Listing
January 2018
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Personalized Mobile Tool AskPCOS Delivering Evidence-Based Quality Information about Polycystic Ovary Syndrome.

Semin Reprod Med 2018 01 6;36(1):66-72. Epub 2018 Sep 6.

Monash Centre for Health Research and Implementation, Clayton, Victoria, Australia.

Despite polycystic ovary syndrome (PCOS) being the most common endocrine condition affecting reproductive-aged women, studies have shown the information needs of PCOS consumers are not currently met. The expressed need by women with PCOS for accessible, evidence-based personalized PCOS information informed the design and development of the PCOS mobile tool-AskPCOS. The App provides a range of unique features such as: evidence-based PCOS health information, self-diagnostic function, a question prompt list to optimize health practitioner engagement, and a commonly asked questions list. Read More

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http://dx.doi.org/10.1055/s-0038-1667156DOI Listing
January 2018
1 Read

Ask PCOS: Identifying Need to Inform Evidence-Based App Development for Polycystic Ovary Syndrome.

Semin Reprod Med 2018 01 6;36(1):59-65. Epub 2018 Sep 6.

Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Clayton, Victoria, Australia.

Background: People are increasingly seeking health information and managing their health through electronic technologies. We aimed to determine if women with polycystic ovary syndrome (PCOS) identified a need for PCOS-related mobile health apps and to evaluate related apps currently available.

Design: A national survey of women and a review of apps available on the iOS and Android platforms. Read More

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http://dx.doi.org/10.1055/s-0038-1667187DOI Listing
January 2018
25 Reads

What Can You Find about Polycystic Ovary Syndrome (PCOS) Online? Assessing Online Information on PCOS: Quality, Content, and User-Friendliness.

Semin Reprod Med 2018 01 6;36(1):50-58. Epub 2018 Sep 6.

Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Clayton, Victoria, Australia.

Background: Polycystic ovary syndrome (PCOS) is a common yet complex condition, where education is vital. It predominantly affects reproductive-aged women, the age group with peak use of the Internet, now a major source of health information. Women with PCOS are dissatisfied with care, and the lack of useful online information is a key concern. Read More

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http://dx.doi.org/10.1055/s-0038-1667186DOI Listing
January 2018
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Evaluation of a Center of Research Excellence in Polycystic Ovary Syndrome as a Large-Scale Collaborative Research Translation Initiative, Including Evaluating Translation of Guideline Impact.

Semin Reprod Med 2018 01 6;36(1):42-49. Epub 2018 Sep 6.

Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Clayton, Victoria, Australia.

Research translation and evaluation are often underconsidered in research design and implementation thus limiting research benefit to the end user. In this article, we first describe a best practice approach to evaluation, for a center of research excellence in polycystic ovary syndrome. Within this, we outline a comprehensive research translation program with inbuilt evaluation of the first (2018). Read More

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http://dx.doi.org/10.1055/s-0038-1667308DOI Listing
January 2018
2 Reads

The Needs of Women and Healthcare Providers regarding Polycystic Ovary Syndrome Information, Resources, and Education: A Systematic Search and Narrative Review.

Semin Reprod Med 2018 01 6;36(1):35-41. Epub 2018 Sep 6.

Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Clayton, Victoria, Australia.

This article aims to identify and summarize the information, resource, and education needs of women with polycystic ovary syndrome (PCOS) and their healthcare providers. A systematic search of peer-reviewed, primary research literature was conducted. A total of 4,230 articles were identified, duplicates were removed, as well as the title and abstract of 2,819 studies and the full texts of 123 studies were screened against predetermined inclusion criteria. Read More

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http://dx.doi.org/10.1055/s-0038-1668086DOI Listing
January 2018
2 Reads

Large-Scale Evidence-Based Guideline Development Engaging the International PCOS Community.

Semin Reprod Med 2018 01 6;36(1):28-34. Epub 2018 Sep 6.

National Health and Medical Research Council, Centre for Research Excellence in PCOS, Monash University, Melbourne, Australia.

The evidence-based guideline for the assessment and management of polycystic ovary syndrome (PCOS) integrates the best available evidence with international, multidisciplinary clinical expertise and consumer preferences to provide health professionals, consumers, and policy makers with high-quality, comprehensive guidance about diagnosing and managing PCOS. Here, we outline the rigorous and systematic process, defined and documented to be reproducible, to minimize bias and maintain transparency, in alignment with the Appraisal of Guidelines for Research and Evaluation (AGREE II) criteria and incorporating the Grading of Recommendations Assessment, Development and Evaluation (GRADE) framework that render this PCOS evidence-based guideline credible, trustworthy, reliable, and useable. Read More

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http://dx.doi.org/10.1055/s-0038-1667312DOI Listing
January 2018
2 Reads

Knowledge and Practices Regarding Polycystic Ovary Syndrome among Physicians in Europe, North America, and Internationally: An Online Questionnaire-Based Study.

Semin Reprod Med 2018 01 6;36(1):19-27. Epub 2018 Sep 6.

Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Clayton, Victoria, Australia.

Background: To inform knowledge translation by identifying evidence-practice gaps in polycystic ovary syndrome (PCOS) care and variations between disciplines and across world regions via an online, anonymous, devised questionnaire distributed via professional societies and completed by 1,495 physicians (2015-2016).

Methods: Multivariable logistic regression analyses generated adjusted odds ratios (OR) and 95% confidence intervals (CI) for associations between outcome measures and world region, specialty, annual patients with PCOS, age, and sex.

Results: Features corresponding to Rotterdam diagnostic criteria were well recognized (e. Read More

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http://dx.doi.org/10.1055/s-0038-1667155DOI Listing
January 2018
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Application of Monash Centre for Health Research and Implementation Framework to the Development of Polycycstic Ovary Syndrome Guideline: A Case Study on Implementation.

Semin Reprod Med 2018 01 6;36(1):13-18. Epub 2018 Sep 6.

Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Clayton, Victoria, Australia.

Implementation of healthcare guidelines, a set of recommendations aiming to optimize patient care, can be a complex process which is at risk of poor translation into practice. Failure to adopt new evidence-based healthcare findings can contribute to a large variation in care, potentially affecting outcomes for service users. Designed to avoid this issue, the Monash Centre for Health Research and Implementation (MCHRI) knowledge translation framework was created to support the development and future implementation of clinical practice guidelines. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0038-1667311
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http://dx.doi.org/10.1055/s-0038-1667311DOI Listing
January 2018
14 Reads

A Summary on Polycystic Ovary Syndrome: Diagnostic Criteria, Prevalence, Clinical Manifestations, and Management According to the Latest International Guidelines.

Semin Reprod Med 2018 01 6;36(1):5-12. Epub 2018 Sep 6.

Monash Centre for Health Research and Implementation, Monash Public Health and Preventive Medicine, Monash University, Clayton, Victoria, Australia.

Polycystic ovary syndrome (PCOS) is a common hormonal condition with reproductive, metabolic, and psychological sequelae. The Rotterdam Criteria are now internationally accepted, with different phenotypes recognized with varying clinical presentations and risk profiles. The complexity of the disorder, and the impact on quality of life, requires timely diagnosis, screening for complications and management strategies. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0038-1668085
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http://dx.doi.org/10.1055/s-0038-1668085DOI Listing
January 2018
12 Reads