1,822 results match your criteria Seminars in Nuclear Medicine [Journal]


Holmium-166 Microsphere Radioembolization of Hepatic Malignancies.

Semin Nucl Med 2019 May 1;49(3):237-243. Epub 2019 Feb 1.

University Medical Center Utrecht (UMCU), Utrecht, Netherlands.

Holmium microspheres have recently become available in the European market as the third type of microspheres for radioembolization of unresectable liver malignancies. Holmium microspheres come with a dedicated administration system, and since these microspheres contain holmium-166 (Ho) instead of yttrium-90, unique dosing and imaging possibilities have become available as well. In addition, a scout dose of Ho microspheres (Conformité Européenne mark is now granted and not pending anymore) can be used instead of Tc-macroaggragated albumin during the preparatory angiography procedure. Read More

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Hepatobiliary Imaging in Liver-directed Treatments.

Semin Nucl Med 2019 May 20;49(3):227-236. Epub 2019 Feb 20.

Department of Radiology and Nuclear Medicine, University Medical Center Utrecht (UMCU), Utrecht, the Netherlands. Electronic address:

Hepatobiliary scintigraphy (HBS) is an emerging tool in the assessment of hepatic function. This nuclear imaging technique can be used to calculate both global and regional liver function. It has proven to be the most reliable way of assessing the distribution of liver function, especially in patients with impaired liver function due to, for example, cirrhosis or after chemotherapy. Read More

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http://dx.doi.org/10.1053/j.semnuclmed.2019.01.007DOI Listing
May 2019
1 Read

Y-Loaded Microsphere SIRT of HCC Patients With Portal Vein Thrombosis: High Clinical Impact of 99mTc-MAA SPECT/CT-Based Dosimetry.

Semin Nucl Med 2019 May 7;49(3):218-226. Epub 2019 Feb 7.

Cancer Institute Eugène Marquis, Department of Nuclear Medicine, Rennes, France; Univ Rennes, INSERM, INRA, Centre de Lutte contre le Cancer Eugène Marquis, Institut NUMECAN (Nutrition Metabolisms and Cancer), Rennes, France.

Radioembolization with Y-loaded microspheres based on classical prescription methods is increasingly applied to hepatocellular carcinoma (HCC) patients with portal vein thrombosis (PVT). In recent years, pretherapeutic predictive dosimetry based on technetium-99m macroaggregated albumin (MAA) quantitative scintigraphy using SPECT/CT has been developed. This paper presents an overview on the MAA-based dosimetry concept, discusses important confounding factors, such segmentation methods, and specific angiographic considerations required for a simulation-based dosimetric evaluation. Read More

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Dosimetry of Y-90 Microspheres Utilizing Tc-99m SPECT and Y-90 PET.

Semin Nucl Med 2019 May 31;49(3):211-217. Epub 2019 Jan 31.

Section of Interventional Radiology, Department of Radiology, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA. Electronic address:

Dosimetry for yttrium-90 radioembolization continues to generate interest and controversy, as multiple approaches have been used effectively. Traditionally, simple formulas primarily based on patients' body weight or perfused liver volume were used. Over the past several years, dosimetry refinements have led to marked improvements in this therapy from both a safety and efficacy standpoint. Read More

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http://dx.doi.org/10.1053/j.semnuclmed.2019.01.005DOI Listing

Angiogenesis in Y-Radioembolization of Colorectal Liver Metastases.

Semin Nucl Med 2019 May 31;49(3):204-210. Epub 2019 Jan 31.

Department of Radiology and Nuclear Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.

In order to evaluate the role of angiogenesis in Y-radioembolization for colorectal cancer liver metastasis an overview was provided of angiogenic growth factors and their function, the angiogenic mechanisms in colorectal cancer, the role of hypoxia, and the advances in antiangiogenic therapy. Last, the use of circulating angiogenic growth factors in Y-radioembolization was reviewed. Two literature searches were conducted. Read More

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http://dx.doi.org/10.1053/j.semnuclmed.2019.01.004DOI Listing

Neoadjuvant Radiation Lobectomy As an Alternative to Portal Vein Embolization in Hepatocellular Carcinoma.

Semin Nucl Med 2019 May 7;49(3):197-203. Epub 2019 Feb 7.

Department of Radiology, Section of Interventional Radiology, Northwestern University, Chicago, IL; Department of Medicine, Division of Hematology and Oncology, Northwestern University, Chicago, IL; Department of Surgery, Division of Transplant Surgery, Northwestern University, Chicago, IL. Electronic address:

Surgical resection is considered first line and potentially curative for early stage hepatocellular carcinoma. However, many patients presenting with small tumors might not qualify as candidates for surgical resection given their small future liver remnant (FLR); such patients tend to undergo neoadjuvant therapies prior to resection to minimize the risk of hepatic decompensation after major hepatic resection. While there are several techniques for inducing FLR hypertrophy, a recent approach in hepatocellular carcinoma is Y90 radiation lobectomy (RL). Read More

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The Role of Radioembolization in Bridging and Downstaging Hepatocellular Carcinoma to Curative Therapy.

Semin Nucl Med 2019 May 23;49(3):189-196. Epub 2019 Feb 23.

Icahn School of Medicine at Mount Sinai, Department of Radiology, New York, NY. Electronic address:

Radioembolization with yttrium-90 microspheres has a growing role in the interventional oncological management of patient's with hepatocellular carcinoma. Patients with Barcelona Clinic Liver Cancer early or intermediate hepatocellular carcinoma may be offered radioembolization in order to control tumor burden while awaiting a transplant organ-referred to as "bridging" a patient to transplantation-or to reduce tumor burden such that patients will subsequently meet criteria for curative therapies-known as "downstaging" a patient to eligible tumor characteristics. More specific applications of radioembolization have been developed over the past two decades. Read More

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May 2019
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Selective Internal Radiation Therapy in the Multidisciplinary Management of Liver Metastases From Colorectal Carcinoma.

Semin Nucl Med 2019 May 14;49(3):182-188. Epub 2019 Feb 14.

Department of Radiation Oncology, Penn State University Hershey College of Medicine, Hershey, PA. Electronic address:

Colorectal cancer (CRC) is the fourth most common cancer in the United States. Most patients diagnosed with CRC will eventually develop metastases. The liver is the most common site of metastases from CRC and liver metastases are the most common cause of death for patients with CRC. Read More

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May 2019
2 Reads

Hepatic Cancers Overview: Surgical and Chemotherapeutic Options, How Do Y-90 Microspheres Fit in?

Semin Nucl Med 2019 May 19;49(3):170-181. Epub 2019 Feb 19.

Department of Medicine, Montefiore Medical Center, Bronx, NY.

Hepatocellular cancer (HCC) is most common primary liver malignancy in adults. Treatment for HCC is a multispecialty undertaking, with surgical, locoregional, and systemic options available. Choice of treatment depends upon patient and disease factors. Read More

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May 2019
1 Read

Letter from the Guest Editors.

Semin Nucl Med 2019 May;49(3):168-169

Montefiore Medical Center, Bronx, New York.

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May 2019
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Letter from the Editors.

Semin Nucl Med 2019 May;49(3):167

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Emergence of "Big Data" and Its Potential and Current Limitations in Medical Imaging.

Authors:
Martin J Yaffe

Semin Nucl Med 2019 03 6;49(2):94-104. Epub 2018 Dec 6.

Physical Sciences Program, Sunnybrook Health Sciences Centre and The University of Toronto, Toronto, ON, Canada. Electronic address:

Although electronic imaging was performed in the early 1950s in nuclear medicine, it was the introduction of computed tomography in 1972 that caused a revolution in medical imaging in that it marked the beginning of the inevitable transformation to digital imaging. This transformation is now more or less complete. While initially these CT images were relatively small, comprised of only about 6400 pixels per slice, the steady move toward higher spatial resolution, multislice imaging, digital radiography, and fluoroscopy rapidly increased the size of images and the amount of data required to be stored, processed, displayed, and moved about in a medical imaging department. Read More

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http://dx.doi.org/10.1053/j.semnuclmed.2018.11.010DOI Listing

Diagnostic Accuracy Studies.

Semin Nucl Med 2019 03 13;49(2):87-93. Epub 2018 Dec 13.

Clinical Epidemiology Program, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario, Canada.

The medical community often assumes that the tests we use to diagnose various diseases are accurate, safe, and effective. However, the study designs traditionally used to determine whether such a diagnostic test is indeed accurate, safe, and effective are often at a higher risk of bias and are of lower methodological quality than those evaluating efficacy of therapeutic interventions. Several designs can be used to study diagnostic tests such as diagnostic accuracy cross-sectional studies, diagnostic accuracy case-control studies, and diagnostic accuracy comparative studies. Read More

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http://dx.doi.org/10.1053/j.semnuclmed.2018.11.005DOI Listing

Letter From the Guest Editors.

Semin Nucl Med 2019 03 7;49(2):85-86. Epub 2018 Dec 7.

Department of Medicine, Division of Nuclear Medicine, University of Ottawa, Ottawa, ON, Canada.

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Seminars in Nuclear Medicine March 2019.

Semin Nucl Med 2019 03 6;49(2):83-84. Epub 2018 Dec 6.

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http://dx.doi.org/10.1053/j.semnuclmed.2018.11.003DOI Listing

American College of Radiology Appropriateness Criteria: Advancing Evidence-Based Imaging Practice.

Semin Nucl Med 2019 03 23;49(2):161-165. Epub 2018 Dec 23.

Department of Radiology, University of Ottawa, Ottawa Hospital Research Institute, Ottawa, ON, Canada.

ACR Appropriateness Criteria (ACR AC) are evidence-based guidelines to assist referring physicians, other providers, and patients in making the most appropriate imaging or treatment decision for a specific clinical condition. The ACR AC are created by expert panels consisting of multidisciplinary physicians, using principles outlined by the Agency for Healthcare Research and Quality as designed by the Institute of Medicine. The ACR AC are qualified appropriate use criteria as designated under the Protecting Access to Medicare Act legislation of 2014. Read More

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http://dx.doi.org/10.1053/j.semnuclmed.2018.11.011DOI Listing
March 2019
1 Read

Society of Nuclear Medicine and Molecular Imaging Efforts Toward Standardization: From Procedure Standards to Appropriate Use Criteria.

Semin Nucl Med 2019 03 26;49(2):153-160. Epub 2018 Dec 26.

Department of Evidence and Quality, Society of Nuclear Medicine and Molecular imaging, Reston, VA. Electronic address:

The Society of Nuclear Medicine and Molecular Imaging (SNMMI) continues to develop clinical guidance documents to synthesize and disseminate clinical information for optimal patient care. Clinical guidelines help standardize delivery of care and improve quality. Chronology of SNMMI efforts in the development of nuclear medicine procedure standards (PS) and appropriate use criteria (AUC) is reviewed. Read More

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Clinical Practice Guidelines: Tools to Support High Quality Patient Care.

Semin Nucl Med 2019 03 10;49(2):145-152. Epub 2019 Jan 10.

Department of Oncology, McMaster University, Hamilton, Ontario, Canada; Program in Evidence-based Care, Cancer Care Ontario, Hamilton, Ontario, Canada.

Clinical practice guidelines (CPGs) are systematically-developed statements aimed to assist decision-making relevant to the clinical encounter, to inform clinical policy, and to strengthen health care systems. The development of a CPG begins with the identification of a problem for which evidence-informed guidance is required. Interdisciplinary panels work to craft - and then execute - a protocol that will serve as a blueprint for the development process. Read More

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http://dx.doi.org/10.1053/j.semnuclmed.2018.11.001DOI Listing
March 2019
5 Reads
3.342 Impact Factor

Knowledge Synthesis in Evidence-Based Medicine.

Semin Nucl Med 2019 03 4;49(2):136-144. Epub 2019 Feb 4.

Ottawa Hospital Research Institute, Clinical Epidemiology Program, Ottawa Methods Centre, Ottawa, Canada. Electronic address:

Systematic reviews are the most common form of knowledge synthesis and remain a cornerstone of the practice of evidence-based medicine. They offer enhanced rigor and validity relative to traditional narrative review articles by reducing bias and increasing objectivity. In answering focused research questions, systematic reviews are directly applicable to clinical practice as well as the development of clinical guidelines and the identification of knowledge gaps, which may drive future primary research directions. Read More

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March 2019
1 Read

Reporting Guidelines for Imaging Research.

Semin Nucl Med 2019 03 6;49(2):121-135. Epub 2018 Dec 6.

The University of Ottawa, Department of Radiology, Ottawa, Canada.

Suboptimal reporting in the publication of imaging research studies is a growing concern. Deficient and incomplete reporting prevents the evaluation of the validity, replicability, and the overall quality of the research. Reporting guidelines are checklists designed to guide researchers about the minimum information to be provided in research studies to allow for adequate quality appraisal and to assess generalizability. Read More

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How to Assess Quality of Primary Research Studies in the Medical Literature?

Semin Nucl Med 2019 03 5;49(2):115-120. Epub 2018 Dec 5.

Service de Médecine Nucléaire, Centre Hospitalier Régional et Universitaire, EA 3878 GETBO, Université de Brest, Brest, France.

Accuracy studies are the cornerstone of the evaluation of new diagnostic tests. In an accuracy study, patients with a clinical suspicion of disease undergo both the new tests that is being evaluated, and the reference test or "gold-standard" test for the disease. Patients are stratified according to the test result and to whether or not the diagnosis was confirmed by the reference test. Read More

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The Changing Landscape of Journalology in Medicine.

Semin Nucl Med 2019 03 18;49(2):105-114. Epub 2018 Dec 18.

Centre for Journalology, Clinical Epidemiology Program, The Ottawa Hospital Research Institute, Ottawa, Canada; School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, Ottawa, Canada. Electronic address:

In the early 1970s, when Seminars in Nuclear Medicine started publication, little was known about the quality of reporting in biomedical journals. Senior scholars were invited to become scientific editors of journals based on their research credibility and stature. Their knowledge of journalology (publication science) was not assessed. Read More

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PET/CT Lung Ventilation and Perfusion Scanning using Galligas and Gallium-68-MAA.

Semin Nucl Med 2019 01 17;49(1):71-81. Epub 2018 Nov 17.

Cancer Imaging, Peter MacCallum Cancer Centre, Melbourne Australia; Sir Peter MacCallum Department of Oncology, the University of Melbourne, Melbourne, Australia. Electronic address:

Ventilation/Perfusion (V/Q) positron emission tomography computed tomography (PET/CT) is now possible by substituting Technetium-99m (Tc) with Gallium-68 (Ga), using the same carrier molecules as conventional V/Q imaging. Ventilation imaging can be performed with Ga-carbon nanoparticles using the same synthesis device as Technegas. Perfusion imaging can be performed with Ga-macroaggregated albumin. Read More

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January 2019
15 Reads

Studies of Radioaerosol Deposition in the Respiratory Tract.

Semin Nucl Med 2019 01;49(1):62-70

Sydney Pharmacy School, Faculty of Medicine and Health, The University of Sydney, Camperdown, New South Wales, Australia.

Deposition of aerosols in the respiratory tract can be quantitatively and qualitatively studied by scintigraphy. The most commonly used radionuclide for this purpose is technetium-99m. The effects of various factors on particle deposition have been investigated by using radiolabeled aerosols in the past decade. Read More

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http://dx.doi.org/10.1053/j.semnuclmed.2018.10.014DOI Listing
January 2019
27 Reads

V/Q SPECT-Normal Values for Lobar Function and Comparison With CT Volumes.

Semin Nucl Med 2019 01 10;49(1):58-61. Epub 2018 Nov 10.

Department of Respiratory Medicine, Royal Prince Alfred Hospital, Sydney, Australia.

Ventilation and perfusion lung imaging with SPECT/CT permits accurate delineation of the individual lobes of the lungs using the CT images for use in ascribing the relative functional contribution to overall lung function of the lobes of both ventilation and perfusion. Moreover, an advantage of using Technegas as the ventilation agent and radiolabelled macro-aggregated albumin microspheres as the perfusion agent is that the deposition pattern is fixed upon administration and thus different patient postures can be studied and the effect of gravity and position determined, even though the scans must be acquired with the subject supine using conventional gamma camera SPECT/CT systems. In this paper we report on normal ranges for functional contribution of the individual lobes of the lung to overall function studied in the supine and erect positions in a small cohort of normal subjects. Read More

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January 2019
7 Reads

Lung Scintigraphy in the Assessment of Aerosol Deposition and Clearance.

Semin Nucl Med 2019 01 22;49(1):47-57. Epub 2018 Nov 22.

Department of Medical Radiation Physics and Nuclear Medicine, Karolinska University Hospital, Stockholm, Sweden; Department of Oncology-pathology. Karolinska Institutet, Stockholm, Sweden. Electronic address:

Environmental and occupational exposure to particulate aerosols is known to have negative health effects. However little is known about how these aerosols trigger the development of pathophysiological mechanisms in the body or the fate of ultrafine particles in the lungs after inhalation. The development of aerosols of different origin that can be labeled to a large variety with radionuclides compatible with clinical gamma camera systems opens the possibility of using lung scintigraphy imaging to study these causalities in detail. Read More

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http://dx.doi.org/10.1053/j.semnuclmed.2018.10.015DOI Listing
January 2019
1 Read

Ventilation/Perfusion SPECT Imaging-Diagnosing Other Cardiopulmonary Diseases Beyond Pulmonary Embolism.

Semin Nucl Med 2019 01 20;49(1):4-10. Epub 2018 Nov 20.

Department of Pulmonary Medicine, Heart and Lung Center, Helsinki University Hospital and Helsinki University, Helsinki, Finland. Electronic address:

Ventilation/perfusion single-photon emission computed tomography (V/P SPECT) is the scintigraphic technique recommended primarily for the diagnosis of acute pulmonary embolism (PE) and is golden standard for the diagnosis of chronic PE. Furthermore, interpreting ventilation and corresponding perfusion images enables pattern recognition of many other cardiopulmonary disorders that affect lung function and also allows quantification of their extent. Using Technegas for the ventilation imaging, grading of small airway disease in COPD is possible and the method is recommended for PE diagnosis in patients with severe COPD that is not possible with radiolabelled liquid aerosols. Read More

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http://dx.doi.org/10.1053/j.semnuclmed.2018.10.012DOI Listing
January 2019
2 Reads

Lung Ventilation/Perfusion Single Photon Emission Computed Tomography (SPECT) in Infants and Children with Nonembolic Chronic Pulmonary Disorders.

Semin Nucl Med 2019 01 15;49(1):37-46. Epub 2018 Nov 15.

Department of Medical Radiation Physics and Nuclear Medicine, Karolinska University Hospital, Stockholm, Sweden; Department of Oncology-Pathology Karolinska Institutet, Stockholm, Sweden. Electronic address:

Single photon emission computed tomography (SPECT) provides high contrast three dimensional images of the regional distribution of a radiotracer. SPECT is a widely used technique in pulmonary investigations of the ventilation (V) and perfusion (Q) in the adult patient, mainly in the diagnosis of pulmonary embolism. However, safety concerns among practitioners due to radiation exposure and the use of macroaggregate albumin for the perfusion scan have historically precluded the use of SPECT in pediatric patients with nonembolic pulmonary disorders. Read More

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January 2019
1 Read

SPECT V/Q in Lung Cancer Radiotherapy Planning.

Semin Nucl Med 2019 01 12;49(1):31-36. Epub 2018 Nov 12.

Department of Nuclear Medicine, Royal North Shore Hospital, Sydney, NSW, Australia; Faculty of Health Sciences, University of Sydney, Sydney, NSW, Australia. Electronic address:

Curative-intent lung cancer radiation therapy either alone (RT) or combined with immuno-chemotherapy is associated with potential risk of serious radiation-induced lung injury. This review provides a summary of the role of SPECT ventilation perfusion (V/Q) imaging as an emerging adjunct to lung cancer RT planning and treatment dosimetry. Denoted "functional lung avoidance RT" it is hypothesized that preferential dosimetric avoidance of physiologically functional lung may reduce the frequency of radiation-induced lung injury. Read More

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January 2019
21 Reads

Pre-surgical Evaluation of Lung Function.

Semin Nucl Med 2019 01 20;49(1):22-30. Epub 2018 Nov 20.

Royal Brompton and Harefield Foundation Trust Hospital, London, UK.

Chronic obstructive pulmonary disease affects 400 million individuals worldwide and is predicted to be the third leading cause of death by 2020 with a projected economic cost of 4.8 trillion US dollars by 2030. Lung volume reduction surgery is an established means of targeting hyperinflation in patients with severe emphysema, optimizing ventilator mechanics, and reducing the work of breathing. Read More

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January 2019
1 Read

Letter From the Guest Editors.

Semin Nucl Med 2019 01 22;49(1):2-3. Epub 2018 Nov 22.

Department of Nuclear Medicine, Royal North Shore Hospital, Sydney, Australia; Faculty of Medicine & Health, University of Sydney, Sydney, Australia.

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January 2019
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Lung Scintigraphy in COPD.

Semin Nucl Med 2019 01 17;49(1):16-21. Epub 2018 Nov 17.

Department of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet, University Hospital of Copenhagen, Copenhagen, Denmark; Faculty of Life Sciences and Education, University of South Wales, Pontypridd, United Kingdom.

Ventilation-perfusion scintigraphy is a functional imaging biomarker that has the potential of captivating the heterogeneity of chronic obstructive pulmonary disease (COPD). It specifically images the distribution of ventilation and perfusion within the lungs, which is a critical pathophysiological component of COPD. The extent of ventilation defects and ventilation inhomogeneity, as well as the ventilation-perfusion ratio distribution thus correlate with severity of disease. Read More

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January 2019
11 Reads

SPECT Ventilation Imaging in Asthma.

Semin Nucl Med 2019 01 20;49(1):11-15. Epub 2018 Nov 20.

Airway Imaging and Physiology Group, The Woolcock Institute of Medical Research, Glebe NSW 2037; Department of Respiratory Medicine, Royal North Shore Hospital, Pacific Highway, St Leonards NSW 2065.

Uneven distribution of ventilation, or ventilation heterogeneity, has been observed in asthma for over 60 years using multiple breath nitrogen washout (MBNW) studies. Ventilation heterogeneity has been known to predict airway hyperresponsiveness (the ability of the airways to constrict too easily and by too much) in asthma, which is a core physiological characteristic of this disease. SPECT ventilation imaging allows topographical analysis of changes in ventilation distribution. Read More

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January 2019
15 Reads

Letter from the Editors.

Semin Nucl Med 2019 01 22;49(1). Epub 2018 Nov 22.

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January 2019
1 Read

Novel Quantitative PET Techniques for Clinical Decision Support in Oncology.

Semin Nucl Med 2018 11 10;48(6):548-564. Epub 2018 Sep 10.

Department of Radiation Oncology, University of Michigan, Ann Arbor, MI.

Quantitative image analysis has deep roots in the usage of positron emission tomography (PET) in clinical and research settings to address a wide variety of diseases. It has been extensively employed to assess molecular and physiological biomarkers in vivo in healthy and disease states, in oncology, cardiology, neurology, and psychiatry. Quantitative PET allows relating the time-varying activity concentration in tissues/organs of interest and the basic functional parameters governing the biological processes being studied. Read More

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November 2018
5 Reads

Nuclear Medicine Imaging of Prostate Cancer in the Elderly.

Semin Nucl Med 2018 Nov 8;48(6):541-547. Epub 2018 Aug 8.

Metropolitan Nuclear Medicine, AOU S.Orsola-Malpighi Hospital, Bologna, Italy; Department of Haematology and Oncology (DIMES), Alma Mater Studiorum, University of Bologna, S.Orsola-Malpighi Hospital, Bologna, Italy. Electronic address:

Due to the increasing life expectancy, the diagnosis of malignancy and treatment of elderly patients is becoming more common. Prostate cancer is particularly frequent in this setting. Many different approaches are now available, but some of them imply significant risks or collateral effects. Read More

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November 2018
16 Reads

Diagnosis and Monitoring of Osteoporosis With F-Sodium Fluoride PET: An Unavoidable Path for the Foreseeable Future.

Semin Nucl Med 2018 Nov 3;48(6):535-540. Epub 2018 Sep 3.

University of Pennsylvania, Philadelphia, PA.

The prevalence of metabolic bone diseases particularly osteoporosis and its precursor, osteopenia, continue to grow as serious global health issues today. On a worldwide perspective, 200million people suffer from osteoporosis and in 2005, over 2million fracture incidents were estimated due to osteoporosis in the United States. Currently, osteoporosis and other metabolic bone diseases are evaluated primarily through dual energy X-ray absorptiometry, and rarely by bone biopsy with tetracycline labeling or Technetium-99m (Tc) based bone scintigraphy. Read More

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November 2018
7 Reads

Applications of PET Imaging in the Evaluation of Musculoskeletal Diseases Among the Geriatric Population.

Semin Nucl Med 2018 Nov 6;48(6):525-534. Epub 2018 Aug 6.

Department of Radiology, Hospital of University of Pennsylvania, Philadelphia, PA. Electronic address:

Medical imaging plays a particularly important role in the care of elderly patients, in whom complex symptomatology and a high prevalence of musculoskeletal diseases necessitate sensitive imaging modalities. MRI is the most commonly used imaging modality in the evaluation of various musculoskeletal disorders. The integration of positron emission technique and computed tomography as well as magnetic resonance imaging allows for generating complimentary data for accurate and quantitative diagnosis. Read More

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November 2018
19 Reads

PET Imaging in Movement Disorders.

Semin Nucl Med 2018 11 16;48(6):513-524. Epub 2018 Aug 16.

Department of Neurology, Washington University in St. Louis, St Louis, MO; Department of Radiology, Washington University in St. Louis, St Louis, MO; Department of Neuroscience, Washington University in St. Louis, St Louis, MO; Department of Physical Therapy, Washington University in St. Louis, St Louis, MO; Department of Occupational Therapy, Washington University in St. Louis, St Louis, MO.

Positron emission tomography (PET) has revealed key insights into the pathophysiology of movement disorders. This paper will focus on how PET investigations of pathophysiology are particularly relevant to Parkinson disease, a neurodegenerative condition usually starting later in life marked by a varying combination of motor and nonmotor deficits. Various molecular imaging modalities help to determine what changes in brain herald the onset of pathology; can these changes be used to identify presymptomatic individuals who may be appropriate for to-be-developed treatments that may forestall onset of symptoms or slow disease progression; can PET act as a biomarker of disease progression; can molecular imaging help enrich homogenous cohorts for clinical studies; and what other pathophysiologic mechanisms relate to nonmotor manifestations. Read More

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http://dx.doi.org/10.1053/j.semnuclmed.2018.07.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195228PMC
November 2018
16 Reads

Cognitive Impairment and Dementias.

Semin Nucl Med 2018 Nov 24;48(6):498-512. Epub 2018 Aug 24.

Department of Radiology, University of Pennsylvania, Philadelphia, PA.

PET has been a key component in the diagnostic armamentarium for evaluating neurodegenerative diseases such as Alzheimer's or Parkinson's disease. PET imaging has been used for the diagnosis of these disorders, for identification of their pathophysiology, and for following treatment of these disorders. Further, PET imaging has been extensively used for both research and clinical purposes. Read More

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http://dx.doi.org/10.1053/j.semnuclmed.2018.07.005DOI Listing
November 2018
20 Reads

The Role of PET in Evaluating Atherosclerosis: A Critical Review.

Semin Nucl Med 2018 Nov 30;48(6):488-497. Epub 2018 Aug 30.

Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, PA.

Atherosclerosis is a common age-related disorder and is the major cause of morbidity and mortality in the developed countries. Structural imaging techniques, such as CT and MRI, have been of limited value in early detection of atherosclerotic plaques, and therefore, there is a dire need for techniques that are highly sensitive and specific for this purpose. Over the past decade, PET imaging with FDG and NaF has been tested for detection and characterization of atherosclerotic plaques in the major coronary arteries. Read More

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http://dx.doi.org/10.1053/j.semnuclmed.2018.07.001DOI Listing
November 2018
16 Reads

Letter from the Guest Editors.

Semin Nucl Med 2018 Nov;48(6):485-487

Department of Nuclear Medicine, Odense University Hospital, Odense, Denmark.

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http://dx.doi.org/10.1053/j.semnuclmed.2018.10.002DOI Listing
November 2018
1 Read

CORRECTION.

Authors:

Semin Nucl Med 2018 11;48(6):484

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November 2018
1 Read

Letter from the Editors.

Semin Nucl Med 2018 Nov;48(6):483-484

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November 2018
1 Read

SPECT/CT in Postoperative Shoulder Pain.

Semin Nucl Med 2018 09 17;48(5):469-482. Epub 2018 Aug 17.

Department of Nuclear Medicine, Ramsay Général de Santé, Hôpital Privé Le Bois, Lille, France; Department of Orthopedic Surgery, Hôpital Riquet, CHU de Toulouse, Toulouse, France.

Over the last 2 decades, the incidence of prosthetic shoulder replacements has increased considerably, leading to a rising number of complications and reoperations. In this article, we review how SPECT/CT can be of significant clinical value for shoulder surgeons. Bone SPECT/CT can provide the correct diagnosis for different types of mechanical complications: glenoiditis after hemiarthroplasty, glenoidal loosening after total shoulder arthroplasty, and scapular notching after reverse shoulder arthroplasty. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00012998183004
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http://dx.doi.org/10.1053/j.semnuclmed.2018.05.004DOI Listing
September 2018
6 Reads

SPECT/CT in Postoperative Foot and Ankle Pain.

Semin Nucl Med 2018 09 18;48(5):454-468. Epub 2018 Apr 18.

Department of Nuclear Medicine, Hôpital Lariboisière, Assistance Publique-Hôpitaux de Paris, Paris, France.

Postoperative pain is a clinically relevant issue in orthopedic patients, affecting more than 40% 1 year after foot and ankle surgery. Because of the very complex anatomy with many different joints and several motion axes, clinical examination and conventional imaging are sometimes not sufficient to identify a local pain generator. Local uptake of bone-seeking radiopharmaceuticals is known to correlate accurately with sites of pain generating foci and, thus, bone scintigraphy has been an established method to evaluate these respective patients for many years. Read More

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September 2018
23 Reads

SPECT/CT in the Postoperative Painful Knee.

Semin Nucl Med 2018 09 21;48(5):439-453. Epub 2018 Jun 21.

Department of Nuclear Medicine, Hôpital Lariboisière, Assistance Publique-Hôpitaux de Paris, Paris, France.

This review summarizes the role of SPECT/CT in patients with a painful postoperative knee and describes typical diagnostic criteria in these patients. Pain after knee surgery is common and is influenced by the underlying pathology, the type of surgery, and the patient. Knee joint-preserving surgery includes osteotomy, ligament reconstruction, meniscus surgery, and cartilage repair procedures, often used in combination. Read More

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http://dx.doi.org/10.1053/j.semnuclmed.2018.05.003DOI Listing
September 2018
17 Reads
3.342 Impact Factor

SPECT/CT in Postoperative Painful Hip Arthroplasty.

Semin Nucl Med 2018 09 19;48(5):425-438. Epub 2018 Jun 19.

Department of Nuclear Medicine, Royal Free London NHS Foundation Trust, London, UK.

Consecutive milestones in hip arthroplasty design and surgical technique have contributed to the successful and cost-effective intervention this procedure has become today in maintaining mobility and quality of life in patients with osteoarthritis, fracture, or other hip conditions. With the increasing prevalence of hip joint replacements, the need for improved diagnostic imaging tools to guide revision surgery has risen in parallel. Over the last few years, promising data have emerged on the potential role of bone SPECT/CT imaging in the assessment of patients with recurrent pain after arthroplasty. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00012998183003
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http://dx.doi.org/10.1053/j.semnuclmed.2018.05.002DOI Listing
September 2018
22 Reads

Bone SPECT/CT in Postoperative Spine.

Semin Nucl Med 2018 09 2;48(5):410-424. Epub 2018 Jul 2.

Department of Nuclear Medicine, Antwerp University Hospital, Edegem, Belgium.; Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk, Belgium.

Back pain is a common problem and the diagnosis and treatment depend on the clinical presentation, yet overlap between pain syndromes is common. Imaging of patients with chronic back pain in both pre- and postoperative scenarios include radiological, radionuclide, and hybrid techniques. In general, these techniques have their own advantages and limitations. Read More

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http://dx.doi.org/10.1053/j.semnuclmed.2018.06.003DOI Listing
September 2018
1 Read

SPECT/CT in Postoperative Hand and Wrist Pain.

Semin Nucl Med 2018 09 19;48(5):396-409. Epub 2018 Jun 19.

Department of Nuclear Medicine, Antwerp University Hospital, Edegem, Belgium; Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk, Belgium.

In this review we summarize the current evidence and experience regarding the performance of SPECT/CT in the evaluation of patients with postoperative painful wrist or hand. There is a wide range of operative wrist and hand interventions due to congenital, traumatic, degenerative, or inflammatory diseases. A significant number of patients suffer from pain after operative procedures. Read More

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http://dx.doi.org/10.1053/j.semnuclmed.2018.05.001DOI Listing
September 2018
15 Reads