1,800 results match your criteria Seminars in Nuclear Medicine [Journal]


PET/CT Lung Ventilation and Perfusion Scanning using Galligas and Gallium-68-MAA.

Semin Nucl Med 2019 01 17;49(1):71-81. Epub 2018 Nov 17.

Cancer Imaging, Peter MacCallum Cancer Centre, Melbourne Australia; Sir Peter MacCallum Department of Oncology, the University of Melbourne, Melbourne, Australia. Electronic address:

Ventilation/Perfusion (V/Q) positron emission tomography computed tomography (PET/CT) is now possible by substituting Technetium-99m (Tc) with Gallium-68 (Ga), using the same carrier molecules as conventional V/Q imaging. Ventilation imaging can be performed with Ga-carbon nanoparticles using the same synthesis device as Technegas. Perfusion imaging can be performed with Ga-macroaggregated albumin. Read More

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http://dx.doi.org/10.1053/j.semnuclmed.2018.10.013DOI Listing
January 2019
10 Reads

Studies of Radioaerosol Deposition in the Respiratory Tract.

Semin Nucl Med 2019 01;49(1):62-70

Sydney Pharmacy School, Faculty of Medicine and Health, The University of Sydney, Camperdown, New South Wales, Australia.

Deposition of aerosols in the respiratory tract can be quantitatively and qualitatively studied by scintigraphy. The most commonly used radionuclide for this purpose is technetium-99m. The effects of various factors on particle deposition have been investigated by using radiolabeled aerosols in the past decade. Read More

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http://dx.doi.org/10.1053/j.semnuclmed.2018.10.014DOI Listing
January 2019
19 Reads

V/Q SPECT-Normal Values for Lobar Function and Comparison With CT Volumes.

Semin Nucl Med 2019 01 10;49(1):58-61. Epub 2018 Nov 10.

Department of Respiratory Medicine, Royal Prince Alfred Hospital, Sydney, Australia.

Ventilation and perfusion lung imaging with SPECT/CT permits accurate delineation of the individual lobes of the lungs using the CT images for use in ascribing the relative functional contribution to overall lung function of the lobes of both ventilation and perfusion. Moreover, an advantage of using Technegas as the ventilation agent and radiolabelled macro-aggregated albumin microspheres as the perfusion agent is that the deposition pattern is fixed upon administration and thus different patient postures can be studied and the effect of gravity and position determined, even though the scans must be acquired with the subject supine using conventional gamma camera SPECT/CT systems. In this paper we report on normal ranges for functional contribution of the individual lobes of the lung to overall function studied in the supine and erect positions in a small cohort of normal subjects. Read More

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January 2019
6 Reads

Lung Scintigraphy in the Assessment of Aerosol Deposition and Clearance.

Semin Nucl Med 2019 01 22;49(1):47-57. Epub 2018 Nov 22.

Department of Medical Radiation Physics and Nuclear Medicine, Karolinska University Hospital, Stockholm, Sweden; Department of Oncology-pathology. Karolinska Institutet, Stockholm, Sweden. Electronic address:

Environmental and occupational exposure to particulate aerosols is known to have negative health effects. However little is known about how these aerosols trigger the development of pathophysiological mechanisms in the body or the fate of ultrafine particles in the lungs after inhalation. The development of aerosols of different origin that can be labeled to a large variety with radionuclides compatible with clinical gamma camera systems opens the possibility of using lung scintigraphy imaging to study these causalities in detail. Read More

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January 2019
1 Read

Ventilation/Perfusion SPECT Imaging-Diagnosing Other Cardiopulmonary Diseases Beyond Pulmonary Embolism.

Semin Nucl Med 2019 01 20;49(1):4-10. Epub 2018 Nov 20.

Department of Pulmonary Medicine, Heart and Lung Center, Helsinki University Hospital and Helsinki University, Helsinki, Finland. Electronic address:

Ventilation/perfusion single-photon emission computed tomography (V/P SPECT) is the scintigraphic technique recommended primarily for the diagnosis of acute pulmonary embolism (PE) and is golden standard for the diagnosis of chronic PE. Furthermore, interpreting ventilation and corresponding perfusion images enables pattern recognition of many other cardiopulmonary disorders that affect lung function and also allows quantification of their extent. Using Technegas for the ventilation imaging, grading of small airway disease in COPD is possible and the method is recommended for PE diagnosis in patients with severe COPD that is not possible with radiolabelled liquid aerosols. Read More

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January 2019
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Lung Ventilation/Perfusion Single Photon Emission Computed Tomography (SPECT) in Infants and Children with Nonembolic Chronic Pulmonary Disorders.

Semin Nucl Med 2019 01 15;49(1):37-46. Epub 2018 Nov 15.

Department of Medical Radiation Physics and Nuclear Medicine, Karolinska University Hospital, Stockholm, Sweden; Department of Oncology-Pathology Karolinska Institutet, Stockholm, Sweden. Electronic address:

Single photon emission computed tomography (SPECT) provides high contrast three dimensional images of the regional distribution of a radiotracer. SPECT is a widely used technique in pulmonary investigations of the ventilation (V) and perfusion (Q) in the adult patient, mainly in the diagnosis of pulmonary embolism. However, safety concerns among practitioners due to radiation exposure and the use of macroaggregate albumin for the perfusion scan have historically precluded the use of SPECT in pediatric patients with nonembolic pulmonary disorders. Read More

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January 2019
1 Read

SPECT V/Q in Lung Cancer Radiotherapy Planning.

Semin Nucl Med 2019 01 12;49(1):31-36. Epub 2018 Nov 12.

Department of Nuclear Medicine, Royal North Shore Hospital, Sydney, NSW, Australia; Faculty of Health Sciences, University of Sydney, Sydney, NSW, Australia. Electronic address:

Curative-intent lung cancer radiation therapy either alone (RT) or combined with immuno-chemotherapy is associated with potential risk of serious radiation-induced lung injury. This review provides a summary of the role of SPECT ventilation perfusion (V/Q) imaging as an emerging adjunct to lung cancer RT planning and treatment dosimetry. Denoted "functional lung avoidance RT" it is hypothesized that preferential dosimetric avoidance of physiologically functional lung may reduce the frequency of radiation-induced lung injury. Read More

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January 2019
13 Reads

Pre-surgical Evaluation of Lung Function.

Semin Nucl Med 2019 01 20;49(1):22-30. Epub 2018 Nov 20.

Royal Brompton and Harefield Foundation Trust Hospital, London, UK.

Chronic obstructive pulmonary disease affects 400 million individuals worldwide and is predicted to be the third leading cause of death by 2020 with a projected economic cost of 4.8 trillion US dollars by 2030. Lung volume reduction surgery is an established means of targeting hyperinflation in patients with severe emphysema, optimizing ventilator mechanics, and reducing the work of breathing. Read More

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January 2019
1 Read

Letter From the Guest Editors.

Semin Nucl Med 2019 01 22;49(1):2-3. Epub 2018 Nov 22.

Department of Nuclear Medicine, Royal North Shore Hospital, Sydney, Australia; Faculty of Medicine & Health, University of Sydney, Sydney, Australia.

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January 2019
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Lung Scintigraphy in COPD.

Semin Nucl Med 2019 01 17;49(1):16-21. Epub 2018 Nov 17.

Department of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet, University Hospital of Copenhagen, Copenhagen, Denmark; Faculty of Life Sciences and Education, University of South Wales, Pontypridd, United Kingdom.

Ventilation-perfusion scintigraphy is a functional imaging biomarker that has the potential of captivating the heterogeneity of chronic obstructive pulmonary disease (COPD). It specifically images the distribution of ventilation and perfusion within the lungs, which is a critical pathophysiological component of COPD. The extent of ventilation defects and ventilation inhomogeneity, as well as the ventilation-perfusion ratio distribution thus correlate with severity of disease. Read More

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January 2019
8 Reads

SPECT Ventilation Imaging in Asthma.

Semin Nucl Med 2019 01 20;49(1):11-15. Epub 2018 Nov 20.

Airway Imaging and Physiology Group, The Woolcock Institute of Medical Research, Glebe NSW 2037; Department of Respiratory Medicine, Royal North Shore Hospital, Pacific Highway, St Leonards NSW 2065.

Uneven distribution of ventilation, or ventilation heterogeneity, has been observed in asthma for over 60 years using multiple breath nitrogen washout (MBNW) studies. Ventilation heterogeneity has been known to predict airway hyperresponsiveness (the ability of the airways to constrict too easily and by too much) in asthma, which is a core physiological characteristic of this disease. SPECT ventilation imaging allows topographical analysis of changes in ventilation distribution. Read More

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January 2019
8 Reads

Letter from the Editors.

Semin Nucl Med 2019 01 22;49(1). Epub 2018 Nov 22.

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January 2019
1 Read

Novel Quantitative PET Techniques for Clinical Decision Support in Oncology.

Semin Nucl Med 2018 11 10;48(6):548-564. Epub 2018 Sep 10.

Department of Radiation Oncology, University of Michigan, Ann Arbor, MI.

Quantitative image analysis has deep roots in the usage of positron emission tomography (PET) in clinical and research settings to address a wide variety of diseases. It has been extensively employed to assess molecular and physiological biomarkers in vivo in healthy and disease states, in oncology, cardiology, neurology, and psychiatry. Quantitative PET allows relating the time-varying activity concentration in tissues/organs of interest and the basic functional parameters governing the biological processes being studied. Read More

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November 2018
5 Reads

Nuclear Medicine Imaging of Prostate Cancer in the Elderly.

Semin Nucl Med 2018 Nov 8;48(6):541-547. Epub 2018 Aug 8.

Metropolitan Nuclear Medicine, AOU S.Orsola-Malpighi Hospital, Bologna, Italy; Department of Haematology and Oncology (DIMES), Alma Mater Studiorum, University of Bologna, S.Orsola-Malpighi Hospital, Bologna, Italy. Electronic address:

Due to the increasing life expectancy, the diagnosis of malignancy and treatment of elderly patients is becoming more common. Prostate cancer is particularly frequent in this setting. Many different approaches are now available, but some of them imply significant risks or collateral effects. Read More

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November 2018
12 Reads

Diagnosis and Monitoring of Osteoporosis With F-Sodium Fluoride PET: An Unavoidable Path for the Foreseeable Future.

Semin Nucl Med 2018 Nov 3;48(6):535-540. Epub 2018 Sep 3.

University of Pennsylvania, Philadelphia, PA.

The prevalence of metabolic bone diseases particularly osteoporosis and its precursor, osteopenia, continue to grow as serious global health issues today. On a worldwide perspective, 200million people suffer from osteoporosis and in 2005, over 2million fracture incidents were estimated due to osteoporosis in the United States. Currently, osteoporosis and other metabolic bone diseases are evaluated primarily through dual energy X-ray absorptiometry, and rarely by bone biopsy with tetracycline labeling or Technetium-99m (Tc) based bone scintigraphy. Read More

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November 2018
5 Reads

Applications of PET Imaging in the Evaluation of Musculoskeletal Diseases Among the Geriatric Population.

Semin Nucl Med 2018 Nov 6;48(6):525-534. Epub 2018 Aug 6.

Department of Radiology, Hospital of University of Pennsylvania, Philadelphia, PA. Electronic address:

Medical imaging plays a particularly important role in the care of elderly patients, in whom complex symptomatology and a high prevalence of musculoskeletal diseases necessitate sensitive imaging modalities. MRI is the most commonly used imaging modality in the evaluation of various musculoskeletal disorders. The integration of positron emission technique and computed tomography as well as magnetic resonance imaging allows for generating complimentary data for accurate and quantitative diagnosis. Read More

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November 2018
11 Reads

PET Imaging in Movement Disorders.

Semin Nucl Med 2018 11 16;48(6):513-524. Epub 2018 Aug 16.

Department of Neurology, Washington University in St. Louis, St Louis, MO; Department of Radiology, Washington University in St. Louis, St Louis, MO; Department of Neuroscience, Washington University in St. Louis, St Louis, MO; Department of Physical Therapy, Washington University in St. Louis, St Louis, MO; Department of Occupational Therapy, Washington University in St. Louis, St Louis, MO.

Positron emission tomography (PET) has revealed key insights into the pathophysiology of movement disorders. This paper will focus on how PET investigations of pathophysiology are particularly relevant to Parkinson disease, a neurodegenerative condition usually starting later in life marked by a varying combination of motor and nonmotor deficits. Various molecular imaging modalities help to determine what changes in brain herald the onset of pathology; can these changes be used to identify presymptomatic individuals who may be appropriate for to-be-developed treatments that may forestall onset of symptoms or slow disease progression; can PET act as a biomarker of disease progression; can molecular imaging help enrich homogenous cohorts for clinical studies; and what other pathophysiologic mechanisms relate to nonmotor manifestations. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195228PMC
November 2018
9 Reads

Cognitive Impairment and Dementias.

Semin Nucl Med 2018 Nov 24;48(6):498-512. Epub 2018 Aug 24.

Department of Radiology, University of Pennsylvania, Philadelphia, PA.

PET has been a key component in the diagnostic armamentarium for evaluating neurodegenerative diseases such as Alzheimer's or Parkinson's disease. PET imaging has been used for the diagnosis of these disorders, for identification of their pathophysiology, and for following treatment of these disorders. Further, PET imaging has been extensively used for both research and clinical purposes. Read More

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November 2018
13 Reads

The Role of PET in Evaluating Atherosclerosis: A Critical Review.

Semin Nucl Med 2018 Nov 30;48(6):488-497. Epub 2018 Aug 30.

Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, PA.

Atherosclerosis is a common age-related disorder and is the major cause of morbidity and mortality in the developed countries. Structural imaging techniques, such as CT and MRI, have been of limited value in early detection of atherosclerotic plaques, and therefore, there is a dire need for techniques that are highly sensitive and specific for this purpose. Over the past decade, PET imaging with FDG and NaF has been tested for detection and characterization of atherosclerotic plaques in the major coronary arteries. Read More

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November 2018
13 Reads

Letter from the Guest Editors.

Semin Nucl Med 2018 Nov;48(6):485-487

Department of Nuclear Medicine, Odense University Hospital, Odense, Denmark.

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November 2018
1 Read

CORRECTION.

Authors:

Semin Nucl Med 2018 11;48(6):484

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November 2018
1 Read

Letter from the Editors.

Semin Nucl Med 2018 Nov;48(6):483-484

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November 2018
1 Read

SPECT/CT in Postoperative Shoulder Pain.

Semin Nucl Med 2018 09 17;48(5):469-482. Epub 2018 Aug 17.

Department of Nuclear Medicine, Ramsay Général de Santé, Hôpital Privé Le Bois, Lille, France; Department of Orthopedic Surgery, Hôpital Riquet, CHU de Toulouse, Toulouse, France.

Over the last 2 decades, the incidence of prosthetic shoulder replacements has increased considerably, leading to a rising number of complications and reoperations. In this article, we review how SPECT/CT can be of significant clinical value for shoulder surgeons. Bone SPECT/CT can provide the correct diagnosis for different types of mechanical complications: glenoiditis after hemiarthroplasty, glenoidal loosening after total shoulder arthroplasty, and scapular notching after reverse shoulder arthroplasty. Read More

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September 2018
6 Reads

SPECT/CT in Postoperative Foot and Ankle Pain.

Semin Nucl Med 2018 09 18;48(5):454-468. Epub 2018 Apr 18.

Department of Nuclear Medicine, Hôpital Lariboisière, Assistance Publique-Hôpitaux de Paris, Paris, France.

Postoperative pain is a clinically relevant issue in orthopedic patients, affecting more than 40% 1 year after foot and ankle surgery. Because of the very complex anatomy with many different joints and several motion axes, clinical examination and conventional imaging are sometimes not sufficient to identify a local pain generator. Local uptake of bone-seeking radiopharmaceuticals is known to correlate accurately with sites of pain generating foci and, thus, bone scintigraphy has been an established method to evaluate these respective patients for many years. Read More

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September 2018
15 Reads

SPECT/CT in the Postoperative Painful Knee.

Semin Nucl Med 2018 09 21;48(5):439-453. Epub 2018 Jun 21.

Department of Nuclear Medicine, Hôpital Lariboisière, Assistance Publique-Hôpitaux de Paris, Paris, France.

This review summarizes the role of SPECT/CT in patients with a painful postoperative knee and describes typical diagnostic criteria in these patients. Pain after knee surgery is common and is influenced by the underlying pathology, the type of surgery, and the patient. Knee joint-preserving surgery includes osteotomy, ligament reconstruction, meniscus surgery, and cartilage repair procedures, often used in combination. Read More

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September 2018
12 Reads
3.342 Impact Factor

SPECT/CT in Postoperative Painful Hip Arthroplasty.

Semin Nucl Med 2018 09 19;48(5):425-438. Epub 2018 Jun 19.

Department of Nuclear Medicine, Royal Free London NHS Foundation Trust, London, UK.

Consecutive milestones in hip arthroplasty design and surgical technique have contributed to the successful and cost-effective intervention this procedure has become today in maintaining mobility and quality of life in patients with osteoarthritis, fracture, or other hip conditions. With the increasing prevalence of hip joint replacements, the need for improved diagnostic imaging tools to guide revision surgery has risen in parallel. Over the last few years, promising data have emerged on the potential role of bone SPECT/CT imaging in the assessment of patients with recurrent pain after arthroplasty. Read More

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September 2018
15 Reads

Bone SPECT/CT in Postoperative Spine.

Semin Nucl Med 2018 09 2;48(5):410-424. Epub 2018 Jul 2.

Department of Nuclear Medicine, Antwerp University Hospital, Edegem, Belgium.; Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk, Belgium.

Back pain is a common problem and the diagnosis and treatment depend on the clinical presentation, yet overlap between pain syndromes is common. Imaging of patients with chronic back pain in both pre- and postoperative scenarios include radiological, radionuclide, and hybrid techniques. In general, these techniques have their own advantages and limitations. Read More

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September 2018
1 Read

SPECT/CT in Postoperative Hand and Wrist Pain.

Semin Nucl Med 2018 09 19;48(5):396-409. Epub 2018 Jun 19.

Department of Nuclear Medicine, Antwerp University Hospital, Edegem, Belgium; Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk, Belgium.

In this review we summarize the current evidence and experience regarding the performance of SPECT/CT in the evaluation of patients with postoperative painful wrist or hand. There is a wide range of operative wrist and hand interventions due to congenital, traumatic, degenerative, or inflammatory diseases. A significant number of patients suffer from pain after operative procedures. Read More

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September 2018
11 Reads

Letter from the Guest Editors.

Semin Nucl Med 2018 09 5;48(5):395. Epub 2018 Jul 5.

Department of Nuclear Medicine, Antwerp University Hospital, Edegem, Belgium; Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk, Belgium. Electronic address:

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September 2018
11 Reads

Letter from the Editors.

Semin Nucl Med 2018 09 25;48(5):393. Epub 2018 Jul 25.

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September 2018
1 Read

Radiation Imagers for Quantitative, Single-particle Digital Autoradiography of Alpha- and Beta-particle Emitters.

Authors:
Brian W Miller

Semin Nucl Med 2018 07 22;48(4):367-376. Epub 2018 Mar 22.

College of Optical Sciences, The University of Arizona, Tucson, AZ. Electronic address:

Promising therapies are being developed or are in early-stage clinical trials that employ the use of alpha- and beta-emitting radionuclides to cure hematologic malignancies. However, these targeted radionuclide therapies have not yet met their expected potential for cancer treatment. A primary reason is lack of biodistribution, dosimetry, and dose-response information at cellular levels, which are directly related to optimal targeting, achieving a requisite therapeutic dose, and assessing the safety profile in normal organs and tissues. Read More

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July 2018
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Innovations in Nuclear Imaging Instrumentation: Cerenkov Imaging.

Semin Nucl Med 2018 07 16;48(4):359-366. Epub 2018 Mar 16.

Molecular Pharmacology, Memorial Sloan Kettering Cancer Center, New York, NY; Pharmacology, Weill Cornell Graduate School, New York, NY; Radiology, Weill Cornell Medicine, New York, NY; Radiology, Memorial Sloan Kettering Cancer Center, New York, NY. Electronic address:

Cerenkov luminescence (CL) is blue glow light produced by charged subatomic particles travelling faster than the phase velocity of light in a dielectric medium such as water or tissue. CL was first discovered in 1934, but for biomedical research it was recognized only in 2009 after advances in optical camera sensors brought the required high sensitivity. Recently, applications of CL from clinical radionuclides have been rapidly expanding to include not only preclinical and clinical biomedical imaging but also an approach to therapy. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251708PMC
July 2018
3 Reads

Absolute Quantitation of SPECT Studies.

Semin Nucl Med 2018 07 19;48(4):348-358. Epub 2018 Mar 19.

Department of Medical Radiation Physics, Lund University, Lund, Sweden. Electronic address:

Methods for absolute quantitation of SPECT images provide an estimate of the activity uptakes in various organs and tissues in units of (M)Bq or (m)Ci. However, because tomographic SPECT images generally are hampered by several physical and camera-specific effects, accurate and precise compensation methods are required. The most important effects are (1) photon attenuation in the patient resulting in a reduction of expected acquired count; (2) the contribution of events from photons, scattered in the phantom and the collimator but accepted by the energy window because of a poor energy resolution of the NaI(Tl) crystal; and (3) the effect of the collimator response function that degrades the image quality because of the relatively poor spatial resolution. Read More

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July 2018
1 Read

PET/MRI Hybrid Systems.

Semin Nucl Med 2018 07 10;48(4):332-347. Epub 2018 Apr 10.

Department of Preclinical Imaging and Radiopharmacy, Werner Siemens Imaging Center, Eberhard Karls University Tuebingen, Tuebingen, Germany.

Over the last decade, the combination of PET and MRI in one system has proven to be highly successful in basic preclinical research, as well as in clinical research. Nowadays, PET/MRI systems are well established in preclinical imaging and are progressing into clinical applications to provide further insights into specific diseases, therapeutic assessments, and biological pathways. Certain challenges in terms of hardware had to be resolved concurrently with the development of new techniques to be able to reach the full potential of both combined techniques. Read More

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July 2018
5 Reads

Innovations in Instrumentation for Positron Emission Tomography.

Semin Nucl Med 2018 07 12;48(4):311-331. Epub 2018 Mar 12.

Department of Biomedical Engineering, University of California, Davis, CA.; Department of Radiology, University of California, Davis, CA. Electronic address:

PET scanners are sophisticated and highly sensitive biomedical imaging devices that can produce highly quantitative images showing the 3-dimensional distribution of radiotracers inside the body. PET scanners are commonly integrated with x-ray CT or MRI scanners in hybrid devices that can provide both molecular imaging (PET) and anatomical imaging (CT or MRI). Despite decades of development, significant opportunities still exist to make major improvements in the performance of PET systems for a variety of clinical and research tasks. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986096PMC
July 2018
1 Read

Guest Editorial.

Authors:
Pat Zanzonico

Semin Nucl Med 2018 07;48(4):309-310

Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY. Electronic address:

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July 2018
7 Reads

Editorial: Innovations in Nuclear Medicine Instrumentation.

Semin Nucl Med 2018 07 12;48(4):307-308. Epub 2018 Apr 12.

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July 2018
2 Reads

Implementation of Quality Systems in Nuclear Medicine: Why It Matters. An Outcome Analysis (Quality Management Audits in Nuclear Medicine Part III).

Semin Nucl Med 2018 05 9;48(3):299-306. Epub 2018 Feb 9.

Nuclear Medicine and Diagnostic Imaging Section, Division of Human Health; IAEA, Vienna, Austria.

The International Atomic Energy Agency (IAEA) developed a comprehensive program-Quality Management Audits in Nuclear Medicine (QUANUM). This program covers all aspects of nuclear medicine practices including, but not limited to, clinical practice, management, operations, and services. The QUANUM program, which includes quality standards detailed in relevant checklists, aims at introducing a culture of comprehensive quality audit processes that are patient oriented, systematic, and outcome based. Read More

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May 2018
13 Reads
3.340 Impact Factor

Molecular Imaging of Vulnerable Plaque.

Semin Nucl Med 2018 05 9;48(3):291-298. Epub 2018 Mar 9.

Molecular Imaging and Therapy Service, Memorial Sloan Kettering Cancer Center, New York, NY.; Division of Cardiology, Icahn School of Medicine at Mount Sinai, New York, NY.

Molecular imaging provides multiple imaging techniques to identify characteristics of vulnerable plaque including I) Inflammatory cells (the presence and metabolic activity of macrophages), II) synthesis of lipid and fatty acid in the plaque, III) the presence of hypoxia in severely inflamed lesions, IV) expression of factors stimulating angiogenesis, V) expression of protease enzymes in the lesion, VI) development of microthrombi in late-phase lesions, VII) apoptosis, and VIII) microcalcification. Read More

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http://dx.doi.org/10.1053/j.semnuclmed.2018.02.004DOI Listing
May 2018
4 Reads

Molecular Imaging of Inflammatory Arthritis and Related Disorders.

Semin Nucl Med 2018 05 10;48(3):277-290. Epub 2018 Jan 10.

Nuclear Medicine Unit, Faculty of Medicine and Psychology, Department of Medical-Surgical Sciences and Translational Medicine, "Sapienza" University, Roma, Italy.

Rheumatic disorders comprise a number of diseases that range from benign, mildly symptomatic degenerative disease to severe systemic disorders such as giant-cell vasculitis with dramatic consequences such as acute blindness. The former is relatively common, whereas the latter is rare. In between, commonly encountered disorders such as rheumatoid arthritis and the various spondyloarthritides, with or without peripheral enthesitis, are daily challenges for the caring physician. Read More

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http://dx.doi.org/10.1053/j.semnuclmed.2017.12.005DOI Listing
May 2018
2 Reads

New SPECT and PET Radiopharmaceuticals for Imaging Inflammatory Diseases: A Meta-analysis of the Last 10 Years.

Semin Nucl Med 2018 05 1;48(3):261-276. Epub 2018 Feb 1.

Nuclear Medicine Unit, Department of Medical-Surgical Sciences and of Translational Medicine, "Sapienza" University of Rome, Italy.; Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, The Netherlands. Electronic address:

Modern molecular nuclear medicine is rapidly developing in the field of imaging of chronic inflammatory diseases, and many new radiopharmaceuticals have been recently described and tested in animals and man. These can detect early pathophysiological changes before the development of anatomical changes and, often, before clinical onset of symptoms. This field includes new radiopharmaceuticals for SPECT and PET use to define new strategies for imaging immune cells as well as tissue modifications induced by the inflammatory process. Read More

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http://dx.doi.org/10.1053/j.semnuclmed.2017.12.004DOI Listing
May 2018
5 Reads

Nuclear Imaging in Sarcoidosis.

Semin Nucl Med 2018 05 9;48(3):246-260. Epub 2018 Mar 9.

Nuclear Medicine Department and DHU FIRE, Bichat-Claude Bernard Hospital, AP-HP, France; University Paris-Diderot, Paris, France; Inserm UMR-S 1148, Paris, France. Electronic address:

Sarcoidosis is a multisystem granulomatosis which may result in a wide variety of clinical and biological presentations. Symptoms are often nonspecific, and incidental abnormal findings on chest radiography is rather common. Although sarcoidosis resolves favorably in most cases, some localizations can provoke functional impairment or even impact on patients' prognosis. Read More

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http://dx.doi.org/10.1053/j.semnuclmed.2018.02.005DOI Listing
May 2018
3 Reads

Imaging Macrophage-associated Inflammation.

Semin Nucl Med 2018 05 13;48(3):242-245. Epub 2018 Feb 13.

Center for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, MD; Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD. Electronic address:

Macrophages belong to the mononuclear phagocyte system comprising closely related cells of bone marrow origin. Activated macrophages are critical in several diseases such as tuberculosis, sarcoidosis, Crohn's disease, and atherosclerosis. Noninvasive imaging techniques that can specifically image activated macrophages could therefore help in differentiating various forms of inflammatory diseases and to monitor therapeutic responses. Read More

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http://dx.doi.org/10.1053/j.semnuclmed.2017.12.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5966362PMC
May 2018
3 Reads

PET/MRI in Infection and Inflammation.

Semin Nucl Med 2018 05;48(3):225-241

Regional Center of Nuclear Medicine, Department of Translational Research and Advanced, Technologies in Medicine, University of Pisa, Pisa, Italy.. Electronic address:

Hybrid positron emission tomography/magnetic resonance imaging (PET/MR) systems are now more and more available for clinical use. PET/MR combines the unique features of MR including excellent soft tissue contrast, diffusion-weighted imaging, dynamic contrast-enhanced imaging, fMRI and other specialized sequences as well as MR spectroscopy with the quantitative physiologic information that is provided by PET. Most of the evidence of the potential clinical utility of PET/MRI is available for neuroimaging. Read More

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http://dx.doi.org/10.1053/j.semnuclmed.2018.02.003DOI Listing
May 2018
4 Reads

The "3M" Approach to Cardiovascular Infections: Multimodality, Multitracers, and Multidisciplinary.

Semin Nucl Med 2018 05 9;48(3):199-224. Epub 2018 Mar 9.

Regional Center of Nuclear Medicine, Department of Translational Research and Advanced Technologies in Medicine, University of Pisa, Pisa, Italy; University Medical Center Groningen, Medical Imaging Center, University of Groningen, Groningen, The Netherlands. Electronic address:

Cardiovascular infections are associated with high morbidity and mortality. Early diagnosis is crucial for adequate patient management, as early treatment improves the prognosis. The diagnosis cannot be made on the basis of a single symptom, sign, or diagnostic test. Read More

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http://dx.doi.org/10.1053/j.semnuclmed.2017.12.003DOI Listing
May 2018
3 Reads

Guest Editorial on Molecular Imaging of Infection and Inflammation.

Semin Nucl Med 2018 05 27;48(3):198. Epub 2018 Feb 27.

Department of Radiology, Donald & Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY. Electronic address:

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http://dx.doi.org/10.1053/j.semnuclmed.2018.02.002DOI Listing
May 2018
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Letter from the Editors-May 2018 Issue.

Semin Nucl Med 2018 05 19;48(3):197. Epub 2018 Feb 19.

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http://dx.doi.org/10.1053/j.semnuclmed.2018.02.001DOI Listing
May 2018
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Currently Available Radiopharmaceuticals for Imaging Infection and the Holy Grail.

Semin Nucl Med 2018 03;48(2):86-99

Department of Radiology, Thomas Jefferson University, Philadelphia, PA 19107; Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107. Electronic address:

Infection is ubiquitous. However, its management is challenging for both the patients and the health-care providers. Scintigraphic imaging of infection dates back nearly half a century. Read More

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http://dx.doi.org/10.1053/j.semnuclmed.2017.10.003DOI Listing
March 2018
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Letter from the Guest Editor.

Semin Nucl Med 2018 03 11;48(2):84-85. Epub 2017 Dec 11.

Department of Radiology, Donald & Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY. Electronic address:

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http://dx.doi.org/10.1053/j.semnuclmed.2017.11.005DOI Listing
March 2018
5 Reads