1,469 results match your criteria Seminars in Immunology [Journal]


Innate lymphoid cells in intestinal cancer development.

Semin Immunol 2019 Feb 14. Epub 2019 Feb 14.

Department of Medicine 1, Friedrich-Alexander-University, Erlangen, Germany. Electronic address:

Colorectal cancer (CRC) is a highly prominent cause of cancer-related deaths worldwide. Although the functions of immune cells in the colorectal tumor microenvironment are complex and heterogeneous, dysregulated changes in the composition and activation state of immune cells are believed to represent key events supporting the establishment of pro- or anti-tumorigenic immune states. Recently, innate lymphoid cells (ILCs) emerged as central innate immune mediators during both gastrointestinal homeostasis and inflammatory pathologies. Read More

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http://dx.doi.org/10.1016/j.smim.2019.02.001DOI Listing
February 2019

Interleukin-1α as an intracellular alarmin in cancer biology.

Semin Immunol 2018 08 26;38:3-14. Epub 2018 Oct 26.

The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, 84105, Israel. Electronic address:

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http://dx.doi.org/10.1016/j.smim.2018.10.006DOI Listing
August 2018
2 Reads

Intracellular Alarmins: Hidden dangers signals crucial for cancer, host defense and inflammatory processes.

Semin Immunol 2018 08 26;38:1-2. Epub 2018 Oct 26.

Department of Internal Medicine and Radboud Center for Infectious diseases (RCI), Radboud University Medical Center, 6525GA Nijmegen, the Netherlands; Human Genomics Laboratory, Craiova University of Medicine and Pharmacy, 200349 Craiova, Romania; Department for Immunology & Metabolism, Life and Medical Sciences Institute (LIMES), University of Bonn, 53115 Bonn, Germany.

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http://dx.doi.org/10.1016/j.smim.2018.10.007DOI Listing
August 2018
1 Read

Vaccination in the elderly: The challenge of immune changes with aging.

Semin Immunol 2018 12;40:83-94

Laboratory of Molecular Microbiology and Biotechnology, Department of Medical Biotechnologies, University of Siena, Viale Bracci 16, 53100, Siena, Italy. Electronic address:

The unprecedented increase of life expectancy challenges society to protect the elderly from morbidity and mortality making vaccination a crucial mean to safeguard this population. Indeed, infectious diseases, such as influenza and pneumonia, are among the top killers of elderly people in the world. Elderly individuals are more prone to severe infections and less responsive to vaccination prevention, due to immunosenescence combined with the progressive increase of a proinflammatory status characteristic of the aging process (inflammaging). Read More

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http://dx.doi.org/10.1016/j.smim.2018.10.010DOI Listing
December 2018
1 Read

Aging, inflammation and cancer.

Semin Immunol 2018 12 6;40:74-82. Epub 2018 Nov 6.

Humanitas Clinical and Research Center, via Manzoni 56, 20089, Rozzano, Milan, Italy; Humanitas University, via Rita Levi Montalcini, 20090, Pieve Emanuele, Milan, Italy; The William Harvey Research Institute, Queen Mary University of London, London, UK. Electronic address:

Aging is a key aspect of neoplasia at the level of cells, individuals and populations. Unrestrained expression and production of inflammatory mediators is a key feature of aging at the cellular and organism level. Inflammatory cells and mediators are a key component of the tumor microenvironment and drive tumor progression. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10445323183008
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http://dx.doi.org/10.1016/j.smim.2018.10.011DOI Listing
December 2018
8 Reads

Immunocorrelates of CAF family adjuvants.

Semin Immunol 2018 10 2;39:4-13. Epub 2018 Nov 2.

Department of Infectious Disease Immunology, Statens Serum Institut, Artillerivej 5, DK-2300, Copenhagen S, Denmark. Electronic address:

The development of the CAF family adjuvant was initiated around 20 years ago when Statens Serum Institut was preparing its first generation protein based recombinant subunit vaccine against tuberculosis for clinical testing, but realized that there were no clinically relevant adjuvants available that would support the strong CMI response needed. Since then the aim for the adjuvant research at Statens Serum Institut has been to provide adjuvants with distinct immunogenicity profiles correlating with protection for any given infectious disease. Two of the adjuvants CAF01 and CAF09 are currently being evaluated in human clinical trials. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10445323183007
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http://dx.doi.org/10.1016/j.smim.2018.10.003DOI Listing
October 2018
11 Reads

The epigenetics of inflammaging: The contribution of age-related heterochromatin loss and locus-specific remodelling and the modulation by environmental stimuli.

Semin Immunol 2018 12 3;40:49-60. Epub 2018 Nov 3.

IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italia. Electronic address:

A growing amount of evidences indicates that inflammaging - the chronic, low grade inflammation state characteristic of the elderly - is the result of genetic as well as environmental or stochastic factors. Some of these, such as the accumulation of senescent cells that are persistent during aging or accompany its progression, seem to be sufficient to initiate the aging process and to fuel it. Others, like exposure to environmental compounds or infections, are temporary and resolve within a (relatively) short time. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10445323183002
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http://dx.doi.org/10.1016/j.smim.2018.10.009DOI Listing
December 2018
9 Reads

Inflammaging 2018: An update and a model.

Semin Immunol 2018 12 2;40:1-5. Epub 2018 Nov 2.

Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Italy; Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy.

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http://dx.doi.org/10.1016/j.smim.2018.10.008DOI Listing
December 2018
4 Reads

Correlates of GLA family adjuvants' activities.

Semin Immunol 2018 10 23;39:22-29. Epub 2018 Oct 23.

Infectious Disease Research Institute, 1616 Eastlake Ave E, Suite 400, Seattle, WA 98102 USA. Electronic address:

Lipopolysaccharide (LPS) is a well-defined agonist of Toll-like receptor (TLR) 4 that activates innate immune responses and influences the development of the adaptive response during infection with Gram-negative bacteria. Many years ago, Dr. Edgar Ribi separated the adjuvant activity of LPS from its toxic effects, an effort that led to the development of monophosphoryl lipid A (MPL). Read More

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http://dx.doi.org/10.1016/j.smim.2018.10.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289613PMC
October 2018
9 Reads

Chemokines sound the alarmin: The role of atypical chemokine in inflammation and cancer.

Semin Immunol 2018 08 15;38:63-71. Epub 2018 Oct 15.

Humanitas Clinical and Research Center, Via Manzoni 113, I-20089 Rozzano, Italy; Department of Medical Biotechnologies and Translational Medicine, Università degli Studi di Milano, Via fratelli Cervi, I-20090 Segrate, Italy. Electronic address:

As main drivers of leukocyte recruitment during inflammatory reactions, chemokines act as mediatrs of alarmins in priming host defense responses after tissue exposure to toxic or infectious agents, immunomediated damage, and in inflammation-driven tumors. Chemokines can therefore be considered alarm signals generated by tissues in a broad number of conditions, and mechanisms controlling chemokines biological activities are therefore key to regulate tissue reactions induced by alarmins. By transporting, presenting or scavenging different sets of chemokines, atypical chemokine receptors represent an emerign subfamily of chemokine receptors which operates in tissues as chemokine gatekeepers in order to establish and shape their gradients and coordinate leukocyte recruitment. Read More

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http://dx.doi.org/10.1016/j.smim.2018.10.005DOI Listing
August 2018
1 Read

Genome wide approaches discover novel Mycobacterium tuberculosis antigens as correlates of infection, disease, immunity and targets for vaccination.

Semin Immunol 2018 10 7;39:88-101. Epub 2018 Jul 7.

Dept. Infectious Diseases, LUMC, PO Box 9600, 2300RC Leiden, The Netherlands.

Every day approximately six thousand people die of Tuberculosis (TB). Its causative agent, Mycobacterium tuberculosis (Mtb), is an ancient pathogen that through its evolution developed complex mechanisms to evade immune surveillance and acquire the ability to establish persistent infection in its hosts. Currently, it is estimated that one-fourth of the human population is latently infected with Mtb and among those infected 3-10% are at risk of developing active TB disease during their lifetime. Read More

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http://dx.doi.org/10.1016/j.smim.2018.07.001DOI Listing
October 2018
2 Reads

Correlates of vaccine adjuvanticity, vaccine activity, protective immunity and disease in human infectious disease and cancer.

Semin Immunol 2018 10 11;39:1-3. Epub 2018 Oct 11.

Dept. Infectious Diseases, Leiden University Medical Center, P.O. Box 9600, 2300RC, Leiden, the Netherlands. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10445323183007
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http://dx.doi.org/10.1016/j.smim.2018.10.002DOI Listing
October 2018
3 Reads

Systems approaches to correlates of protection and progression to TB disease.

Authors:
Helen A Fletcher

Semin Immunol 2018 10 10;39:81-87. Epub 2018 Oct 10.

TB Centre, London School of Hygiene & Tropical Medicine, London, UK. Electronic address:

Tuberculosis (TB) is the leading cause of death due to a single infectious disease and an effective vaccine would substantially accelerate global efforts to control TB. An immune correlate of protection (CoP) from TB disease could aid vaccine optimization and licensure. This paper summarises opportunities for identifying CoP and highlights results from correlates of risk studies. Read More

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http://dx.doi.org/10.1016/j.smim.2018.10.001DOI Listing
October 2018
1 Read

Pro-resolving lipid mediators: Agents of anti-ageing?

Semin Immunol 2018 12 4;40:36-48. Epub 2018 Oct 4.

School of Medicine, University College Dublin, Belfield, Dublin 4, Ireland.

Inflammation is an essential response to injury and its timely and adequate resolution permits tissue repair and avoidance of chronic inflammation. Ageing is associated with increased inflammation, sub-optimal resolution and these act as drivers for a number of ageing-associated pathologies. We describe the role played by specialised proresolving lipid mediators (SPMs) in the resolution of inflammation and how insufficient levels of these mediators, or compromised responsiveness may play a role in the pathogenesis of many ageing-associated pathologies, e. Read More

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http://dx.doi.org/10.1016/j.smim.2018.09.002DOI Listing
December 2018
1 Read

The integration of inflammaging in age-related diseases.

Semin Immunol 2018 12 2;40:17-35. Epub 2018 Oct 2.

Singapore Immunology Network (SIgN), Agency for Science Technology and Research (A⁎STAR), Immunos Building, Biopolis, Singapore, Singapore; Department of Biology, Faculty of Science, University Tunis El Manar, Tunis, Tunisia.

Aging is characterized by a morpho-functional adaptation, variably affecting major physiological systems, depending on a complex interaction between genetic, environmental and stochastic factors. This dynamic interaction drives an age-related remodelling of a number of pathways/systems, providing the chance to reach the extreme limit of human life in healthy state which is reflected in the ever-increasing number of centenarians. This conceptualization implies that aging process per se and the development of the most common age-related diseases (ARD) are somewhat separate but must share somehow common set of basic biological mechanisms. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10445323183002
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http://dx.doi.org/10.1016/j.smim.2018.09.003DOI Listing
December 2018
16 Reads

NLRP3 inflammasome activation in inflammaging.

Semin Immunol 2018 12 26;40:61-73. Epub 2018 Sep 26.

Institute of Innate Immunity, University of Bonn, 53127, Bonn, Germany. Electronic address:

The process of aging is associated with the appearance of low-grade subclinical inflammation, termed inflammaging, that can accelerate age-related diseases. In Western societies the age-related inflammatory response can additionally be aggravated by an inflammatory response related to modern lifestyles and excess calorie consumption, a pathophysiologic inflammatory response that was coined metaflammation. Here, we summarize the current knowledge of mechanisms that drive both of these processes and focus our discussion the emerging concept that a key innate immune pathway, the NLRP3 inflammasome, is centrally involved in the recognition of triggers that appear during physiological aging and during metabolic stress. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10445323183006
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http://dx.doi.org/10.1016/j.smim.2018.09.001DOI Listing
December 2018
9 Reads

Changes in the biochemical taste of cytoplasmic and cell-free DNA are major fuels for inflamm-aging.

Semin Immunol 2018 12 15;40:6-16. Epub 2018 Sep 15.

Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna Italy; Bioscience Laboratory, Istituto Romagnolo per lo Studio e la Cura dei tumori IRST, IRCCS, Meldola, Forlì, Italy. Electronic address:

Inflamm-aging depicts the progressive activation of the innate immune system that accompanies human aging. Its role as a disease-predisposing condition has been proposed, but its molecular basis is still poorly understood. A wealth of literature conveys that, particularly upon stress, nuclear and mitochondrial genomes are released into the cytoplasmic and extracellular compartments. Read More

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http://dx.doi.org/10.1016/j.smim.2018.08.003DOI Listing
December 2018
1 Read

Correlating efficacy and immunogenicity in malaria vaccine trials.

Semin Immunol 2018 10 12;39:52-64. Epub 2018 Sep 12.

Institut für Tropenmedizin, Universität Tübingen and Deutsches Zentrum für Infektionsforschung, Germany; Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon.

The availability of an effective and appropriately implemented malaria vaccine would form a crucial cornerstone of public health efforts to fight this disease. Despite many decades of research, however, no malaria vaccine has yet shown satisfactory protective efficacy or been rolled-out. Validated immunological substitute endpoints have the potential to accelerate clinical vaccine development by reducing the required complexity, size, duration and cost of clinical trials. Read More

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http://dx.doi.org/10.1016/j.smim.2018.08.002DOI Listing
October 2018
1 Read

Alarmins of the extracellular space.

Semin Immunol 2018 08 28;38:33-39. Epub 2018 Aug 28.

McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, United States; Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States. Electronic address:

The ability of the immune system to discriminate between healthy-self, abnormal-self, and non-self has been attributed mainly to alarmins signaling as "danger signals". It is now evident, however, that alarmins are much more complex and can perform specialized functions that can regulate a wide spectrum of processes ranging from propagation of disease to tissue homeostasis. As such, alarmins and their signaling mechanisms are now actively pursued as therapeutic targets. Read More

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http://dx.doi.org/10.1016/j.smim.2018.08.004DOI Listing
August 2018
3 Reads

Systems analysis of human vaccine adjuvants.

Authors:
Ali M Harandi

Semin Immunol 2018 10 16;39:30-34. Epub 2018 Aug 16.

Department of Microbiology and Immunology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Sweden. Electronic address:

The discovery and wide spread use of vaccines have saved millions of lives in the past few decades. Vaccine adjuvants represent an integral part of the modern vaccines. Despite numerous efforts, however, only a handful of vaccine adjuvants is currently available for human use. Read More

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http://dx.doi.org/10.1016/j.smim.2018.08.001DOI Listing
October 2018
1 Read

Correlates of vaccine-induced protective immunity against Ebola virus disease.

Semin Immunol 2018 10 21;39:65-72. Epub 2018 Jul 21.

Centre for Vaccinology, University and University Hospitals of Geneva, 1211 Geneva, Switzerland. Electronic address:

Ebola virus disease is a deadly infection which occurs in sporadic outbreaks. Several vaccine candidates have been developed. The most advanced candidate is the recombinant VSVΔG-ZEBOV-GP vaccine, in which the Vesicular Stomatitis Virus (VSV) envelope glycoprotein is replaced by the Zaire strain Ebola virus (ZEBOV) glycoprotein (GP). Read More

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http://dx.doi.org/10.1016/j.smim.2018.07.003DOI Listing
October 2018
1 Read

The potential of metabolic profiling for vaccine development.

Semin Immunol 2018 10 19;39:44-51. Epub 2018 Jul 19.

Max Planck Institute for Infection Biology, Berlin, Germany. Electronic address:

Recent technological advances have provided deeper insights into the role of small molecules in biological processes. Metabolic profiling has thus entered the arena of -omics studies and rapidly proven its value both as stand-alone and as complement to other more advanced approaches, notably transcriptomics. Here we describe the potential of metabolic profiling for vaccinology embedded in the context of infection and immunity. Read More

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http://dx.doi.org/10.1016/j.smim.2018.07.002DOI Listing
October 2018
5 Reads

Non-specific effects of vaccines: Current evidence and potential implications.

Semin Immunol 2018 10 11;39:35-43. Epub 2018 Jul 11.

Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, The Netherlands; Department for Genomics & Immunoregulation, Life and Medical Sciences Institute (LIMES), University of Bonn, Bonn, Germany. Electronic address:

Besides protection against specific microorganisms, vaccines can induce heterologous or non-specific effects (NSE). Epidemiological data suggest that vaccination with live-attenuated vaccines such as Bacillus Calmette-Guérin (BCG), measles vaccine, and oral polio vaccine results in increased overall childhood survival, and several of these observations have been confirmed in randomized trials. Immunological mechanisms mediating NSE include heterologous lymphocyte effects and induction of innate immune memory (trained immunity). Read More

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http://dx.doi.org/10.1016/j.smim.2018.06.002DOI Listing
October 2018
9 Reads

Correlates of immune exacerbations in leprosy.

Authors:
Annemieke Geluk

Semin Immunol 2018 10 24;39:111-118. Epub 2018 Jun 24.

Dept. of Infectious Diseases, LUMC, PO Box 9600, 2300 RC Leiden, The Netherlands. Electronic address:

Leprosy is still a considerable health threat in pockets of several low and middle income countries worldwide where intense transmission is witnessed, and often results in irreversible disabilities and deformities due to delayed- or misdiagnosis. Early detection of leprosy represents a substantial hurdle in present-day leprosy health care. The dearth of timely diagnosis has, however, particularly severe consequences in the case of inflammatory episodes, designated leprosy reactions, which represent the major cause of leprosy-associated irreversible neuropathy. Read More

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http://dx.doi.org/10.1016/j.smim.2018.06.003DOI Listing
October 2018
15 Reads

The potential of imaging tools as correlates of infection and disease for new TB vaccine development.

Semin Immunol 2018 10 18;39:73-80. Epub 2018 Jun 18.

DST/NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa. Electronic address:

The development of an improved vaccine to stimulate an effective response against Mycobacterium tuberculosis (MTB) infection and disease will be a major breakthrough in the fight against TB. A lack of tools to adequately track the progression or resolution of events in TB pathogenesis that occur at bacterial loads below the threshold for culture in human samples seriously hampers vaccine development and evaluation. In this review we discuss recent studies that use new imaging applications, modalities and analysis techniques to provide insight into the dynamic processes of MTB infection and disease that are challenging to monitor. Read More

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http://dx.doi.org/10.1016/j.smim.2018.06.001DOI Listing
October 2018
3 Reads

Antibody glycosylation in inflammation, disease and vaccination.

Semin Immunol 2018 10 11;39:102-110. Epub 2018 Jun 11.

Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands. Electronic address:

Antibodies are antigen recognizing immunoglobulins with an amazingly diverse repertoire in the antigen specific domain. The diversity of the antibody response is further increased by modifications such as somatic recombination and hypermutation. Furthermore, variation in the isotype and post-translational modifications such as Fc glycosylation further increase diversity of the effector functions. Read More

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http://dx.doi.org/10.1016/j.smim.2018.05.003DOI Listing
October 2018
20 Reads

Back to the future - non-canonical functions of complement.

Semin Immunol 2018 06;37:1-3

Institute for Systemic Inflammation Research, University of Lübeck, 23562Lübeck, Germany; Division of Immunobiology, Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH45229, USA.

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http://dx.doi.org/10.1016/j.smim.2018.05.002DOI Listing
June 2018
2 Reads

Correlates of adjuvanticity: A review on adjuvants in licensed vaccines.

Semin Immunol 2018 10 23;39:14-21. Epub 2018 May 23.

GSK, Rixensart, Belgium.

After decades of slow progress, the last years have seen a rapid acceleration of the development of adjuvanted vaccines which have lately been approved for human use. These adjuvants consist of different components, e.g. Read More

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http://dx.doi.org/10.1016/j.smim.2018.05.001DOI Listing
October 2018
15 Reads

Insights into the role of IL-32 in cancer.

Semin Immunol 2018 08 8;38:24-32. Epub 2018 May 8.

Department of Internal Medicine, Radboud University Medical Center, Geert Grooteplein Zuid 8, 6525 GA, Nijmegen, The Netherlands; Department of Internal Medicine, Division of Endocrinology, Radboud University Medical Center, Geert Grooteplein Zuid 8, 6525 GA, Nijmegen, The Netherlands. Electronic address:

Interleukin 32 (IL-32) is a proinflammatory cytokine involved in the development of several diseases, including cancer. IL-32 is a rather peculiar cytokine because its protein structure does not show resemblance with any of the known cytokines, and an IL-32 receptor to facilitate extracellular signaling has not yet been identified. Thus far, 9 isoforms of IL-32 have been described, all of which show differences in terms of effects and in potency to elicit a specific effect. Read More

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http://dx.doi.org/10.1016/j.smim.2018.03.004DOI Listing
August 2018
2 Reads

Correlates of immune and clinical activity of novel cancer vaccines.

Semin Immunol 2018 10 27;39:119-136. Epub 2018 Apr 27.

Department of Medical Oncology, Leiden University Medical Center, Building 1, C7-P, PO box 9600, 2300 RC Leiden, The Netherlands. Electronic address:

Cancer vaccines are solely meant to amplify the pool of type 1 cytokine oriented CD4+ and CD8+ T cells that recognize tumor antigen and ultimately foster control and destruction of a growing tumor. They are not designed to deal with all aspects of immune ignorance, exclusion, suppression and escape that are generally in place in patients with cancer and may prevent the T cells to enter the tumor or to exert their effector function. This simple fact prompted for a reappraisal of the many recent trials in which therapeutic cancer vaccines have been examined as monotherapy. Read More

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http://dx.doi.org/10.1016/j.smim.2018.04.001DOI Listing
October 2018
3 Reads

Intracellular complement activation-An alarm raising mechanism?

Semin Immunol 2018 08 7;38:54-62. Epub 2018 Apr 7.

Department of Bacteriology and Immunology, Haartman Institute, Immunobiology Research Program, University of Helsinki, Helsinki, Finland; Helsinki University Central Hospital Laboratory (HUSLAB), Helsinki, Finland. Electronic address:

It has become increasingly apparent that the complement system, being an ancient defense mechanism, is not operative only in the extracellular milieu but also intracellularly. In addition to the known synthetic machinery in the liver and by macrophages, many other cell types, including lymphocytes, adipocytes and epithelial cells produce selected complement components. Activation of e. Read More

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http://dx.doi.org/10.1016/j.smim.2018.03.003DOI Listing
August 2018
4 Reads

The critical role of C5a as an initiator of neutrophil-mediated autoimmune inflammation of the joint and skin.

Semin Immunol 2018 06 27;37:21-29. Epub 2018 Mar 27.

Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

The deposition of IgG autoantibodies in peripheral tissues and the subsequent activation of the complement system, which leads to the accumulation of the anaphylatoxin C5a in these tissues, is a common hallmark of diverse autoimmune diseases, including rheumatoid arthritis (RA) and pemphigoid diseases (PDs). C5a is a potent chemoattractant for granulocytes and mice deficient in its precursor C5 or its receptor C5aR1 are resistant to granulocyte recruitment and, consequently, to tissue inflammation in several models of autoimmune diseases. However, the mechanism whereby C5a/C5aR regulates granulocyte recruitment in these diseases has remained elusive. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10445323173013
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http://dx.doi.org/10.1016/j.smim.2018.03.002DOI Listing
June 2018
4 Reads

Pathogen clearance and immune adherence "revisited": Immuno-regulatory roles for CRIg.

Semin Immunol 2018 06 21;37:4-11. Epub 2018 Mar 21.

Institute for Systemic Inflammation Research, Universität zu Lübeck, 23538 Lübeck, Germany. Electronic address:

Rapid elimination of microbes from the bloodstream, along with the ability to mount an adaptive immune response, are essential for optimal host-defense. Kupffer cells are strategically positioned in the liver sinusoids and efficiently capture circulating microbes from the hepatic artery and portal vein, thus preventing bacterial dissemination. In vivo and in vitro studies have probed how complement receptor of the immunoglobulin superfamily (CRIg), also referred to as Z39Ig and V-set and Ig domain-containing 4 (VSIG4), acts as a critical player in pathogen recognition and clearance. Read More

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http://dx.doi.org/10.1016/j.smim.2018.02.007DOI Listing
June 2018
2 Reads

The mesenchymal and myeloid regulation of immunity: Power is nothing without control.

Authors:
Vincenzo Bronte

Semin Immunol 2018 02;35:1-2

Department of Medicine, Verona University Hospital, Verona, Italy.

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http://dx.doi.org/10.1016/j.smim.2018.03.001DOI Listing
February 2018
3 Reads

Interleukin-32: An endogenous danger signal or master regulator of intracellular pathogen infections-Focus on leishmaniases.

Semin Immunol 2018 08 15;38:15-23. Epub 2018 Mar 15.

Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás, Goiânia, Goiás, Brazil. Electronic address:

Interleukin 32 (IL-32) is an intracellular cytokine produced by immune and non immune cells after different stimuli. It contributes to inflammation and control of intracellular pathogens mainly by inducing proinflammatory cytokines and microbicidal molecules. Evidence is rising showing that IL-32 can be considered an endogenous danger signal after tissue injury, amplifying the inflammatory process and acquired immune responses. Read More

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http://dx.doi.org/10.1016/j.smim.2018.02.010DOI Listing
August 2018
3 Reads

Re-thinking our understanding of immunity: Robustness in the tissue reconstruction system.

Semin Immunol 2018 04 15;36:45-55. Epub 2018 Mar 15.

ImmunoConcept, UMR5164, Immunology, CNRS, University of Bordeaux, Bordeaux, France. Electronic address:

Robustness, understood as the maintenance of specific functionalities of a given system against internal and external perturbations, is pervasive in today's biology. Yet precise applications of this notion to the immune system have been scarce. Here we show that the concept of robustness sheds light on tissue repair, and particularly on the crucial role the immune system plays in this process. Read More

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http://dx.doi.org/10.1016/j.smim.2018.02.013DOI Listing
April 2018
3 Reads

High-mobility group box 1 protein (HMGB1) operates as an alarmin outside as well as inside cells.

Semin Immunol 2018 08 9;38:40-48. Epub 2018 Mar 9.

Unit of Rheumatology, Department of Medicine, Center for Molecular Medicine (CMM) L8:04, Karolinska Institutet, Karolinska University Hospital, 17176 Stockholm, Sweden. Electronic address:

Alarmins are preformed, endogenous molecules that can be promptly released to signal cell or tissue stress or damage. The ubiquitous nuclear molecule high-mobility group box 1 protein (HMGB1) is a prototypical alarmin activating innate immunity. HMGB1 serves a dual alarmin function. Read More

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http://dx.doi.org/10.1016/j.smim.2018.02.011DOI Listing
August 2018
4 Reads

Complement in stem cells and development.

Semin Immunol 2018 06 8;37:74-84. Epub 2018 Mar 8.

School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, St. Lucia, Queensland, Australia; Wesley Medical Research, Auchenflower, Brisbane, Queensland, Australia. Electronic address:

From its discovery in the late nineteenth century, as a 'complement' to the cellular immune response, the complement system has been widely affirmed as a powerful controller of innate and adaptive immune responses. In recent decades however, new roles for complement have been discovered, with multiple complement proteins now known to function in a broad array of non-immune systems. This includes during development, where complement exerts control over stem cell populations from fertilization and implantation throughout embryogenesis and beyond post-natal development. Read More

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http://dx.doi.org/10.1016/j.smim.2018.02.009DOI Listing
June 2018
3 Reads

The immunological functions of the Appendix: An example of redundancy?

Semin Immunol 2018 04 2;36:31-44. Epub 2018 Mar 2.

Innate Pharma Research Labs, Innate Pharma, Marseille; Aix Marseille Univ, CNRS, INSERM, Centre d'Immunologie de Marseille-Luminy, Marseille, France; Service d'Immunologie, Marseille Immunopole, Hôpital de la Timone, Assistance Publique des Hôpitaux de Marseille. Electronic address:

Biological redundancy ensures robustness in living organisms at several levels, from genes to organs. In this review, we explore the concept of redundancy and robustness through an analysis of the caecal appendix, an organ that is often considered to be a redundant remnant of evolution. However, phylogenic data show that the Appendix was selected during evolution and is unlikely to disappear once it appeared. Read More

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http://dx.doi.org/10.1016/j.smim.2018.02.005DOI Listing
April 2018
5 Reads

High-mobility group nucleosome binding domain 1 (HMGN1) functions as a Th1-polarizing alarmin.

Semin Immunol 2018 08 16;38:49-53. Epub 2018 Aug 16.

Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute at Frederick, National Institute of Health, USA. Electronic address:

High-mobility group (HMG) nucleosome binding domain 1 (HMGN1), which previously was thought to function only as a nucleosome-binding protein that regulates chromatin structure, histone modifications, and gene expression, was recently discovered to be an alarmin that contributes extracellularly to the generation of innate and adaptive immune responses. HMGN1 promotes DC recruitment through interacting with a Gαi protein-coupled receptor (GiPCR) and activates DCs predominantly through triggering TLR4. HMGN1 preferentially promotes Th1-type immunity, which makes it relevant for the fields of vaccinology, autoimmunity, and oncoimmunology. Read More

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http://dx.doi.org/10.1016/j.smim.2018.02.012DOI Listing
August 2018
4 Reads

The dark side of tumor-associated endothelial cells.

Semin Immunol 2018 02 26;35:35-47. Epub 2018 Feb 26.

Ovarian Cancer Research Center (OCRC), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address:

Angiogenesis is a hallmark of cancer and a requisite that tumors must achieve to fulfill their metabolic needs of nutrients and oxygen. As a critical step in cancer progression, the 'angiogenic switch' allows tumor cells to survive and grow, and provides them access to vasculature resulting in metastatic progression and dissemination. Tumor-dependent triggering of the angiogenic switch has critical consequences on tumor progression which extends from an increased nutrient supply and relies instead on the ability of the tumor to hijack the host immune response for the generation of a local immunoprivileged microenvironment. Read More

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http://dx.doi.org/10.1016/j.smim.2018.02.002DOI Listing
February 2018
4 Reads

The intestinal complement system in inflammatory bowel disease: Shaping intestinal barrier function.

Semin Immunol 2018 06 24;37:66-73. Epub 2018 Feb 24.

Institute of Nutritional Medicine, Molecular Gastroenterology, University Hospital Schleswig-Holstein, Campus Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany. Electronic address:

The complement system is part of innate sensor and effector systems such as the Toll-like receptors (TLRs). It recognizes and quickly systemically and/or locally respond to microbial-associated molecular patterns (MAMPs) with a tailored defense reaction. MAMP recognition by intestinal epithelial cells (IECs) and appropriate immune responses are of major importance for the maintenance of intestinal barrier function. Read More

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http://dx.doi.org/10.1016/j.smim.2018.02.008DOI Listing
June 2018
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An unexpected player in Gaucher disease: The multiple roles of complement in disease development.

Semin Immunol 2018 06 23;37:30-42. Epub 2018 Feb 23.

Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA; The Department of Pediatrics of the University of Cincinnati College of Medicine, Cincinnati, OH, 45229, USA; Institute for Systemic Inflammation Research, University of Lübeck, 23562, Lübeck, Germany. Electronic address:

The complement system is well appreciated for its role as an important effector of innate immunity that is activated by the classical, lectin or alternative pathway. C5a is one important mediator of the system that is generated in response to canonical and non-canonical C5 cleavage by circulating or cell-derived proteases. In addition to its function as a chemoattractant for neutrophils and other myeloid effectors, C5a and its sister molecule C3a have concerted roles in cell homeostasis and surveillance. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10445323173010
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http://dx.doi.org/10.1016/j.smim.2018.02.006DOI Listing
June 2018
9 Reads

Janus face of complement-driven neutrophil activation during sepsis.

Semin Immunol 2018 06 14;37:12-20. Epub 2018 Feb 14.

Institute of Clinical and Experimental Trauma Immunology, Ulm University Hospital, Helmholtzstr. 8/1, 89081 Ulm, Germany. Electronic address:

During local and systemic inflammation, the complement system and neutrophil granulocytes are activated not only by pathogens, but also by released endogenous danger signals. It is recognized increasingly that complement-mediated neutrophil activation plays an ambivalent role in sepsis pathophysiology. According to the current definition, the onset of organ dysfunction is a hallmark of sepsis. Read More

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http://dx.doi.org/10.1016/j.smim.2018.02.004DOI Listing
June 2018
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Targeting complement-mediated immunoregulation for cancer immunotherapy.

Semin Immunol 2018 06 15;37:85-97. Epub 2018 Feb 15.

Department of Immunotherapeutics and Biotechnology, School of Pharmacy, Texas Tech University Health Sciences Center, Abilene, TX, 79601, United States. Electronic address:

Complement was initially discovered as an assembly of plasma proteins "complementing" the cytolytic activity of antibodies. However, our current knowledge places this complex system of several plasma proteins, receptors, and regulators in the center of innate immunity as a bridge between the initial innate responses and adaptive immune reactions. Consequently, complement appears to be pivotal for elimination of pathogens, not only as an early response defense, but by directing the subsequent adaptive immune response. Read More

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http://dx.doi.org/10.1016/j.smim.2018.02.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984681PMC
June 2018
5 Reads

Mast cells, basophils and eosinophils: From allergy to cancer.

Semin Immunol 2018 02 7;35:29-34. Epub 2018 Feb 7.

Department of Medicine, University of Udine, 33100 Udine, Italy.

Basophils, eosinophils and mast cells were first recognized by Paul Ehrlich in the late 19th century. These cells have common, but non-redundant roles, in the pathogenesis of allergic diseases and in the protection against parasites. Nevertheless, in virtue of their shared-adeptness to produce a huge variety of immunological mediators and express membrane-bound receptors, they are able to interact with immune and non-immune components of the tissue microenvironment, contributing to the regulation of tissue homeostasis and immune response while participating to further deregulation of tissues transforming into neoplasia. Read More

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http://dx.doi.org/10.1016/j.smim.2018.02.001DOI Listing
February 2018
2 Reads

Complement links platelets to innate immunity.

Semin Immunol 2018 06 6;37:43-52. Epub 2018 Feb 6.

Department of Cardiology and Cardiovascular Medicine, University Clinic, Eberhard Karls-University Tübingen, Germany; Section for Cardioimmunology, Inflammatory Cardiovascular Diseases, Eberhard Karls-University Tübingen, Germany. Electronic address:

The complement system is a versatile part of our immune system. Various intersection points of complement with other cells and molecules of the immune response are well described. Platelets are classically conceived as cells of hemostasis. Read More

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http://dx.doi.org/10.1016/j.smim.2018.01.003DOI Listing
June 2018
4 Reads

Complement involvement in bone homeostasis and bone disorders.

Semin Immunol 2018 06 1;37:53-65. Epub 2018 Feb 1.

Institute of Orthopaedic Research and Biomechanics, Center for Trauma Research Ulm (ZTF Ulm), University Medical Center Ulm, Ulm, Germany. Electronic address:

An integral part of innate immunity is the complement system, a defence system, consisting of fluid-phase and cell surface-bound proteins. Its role to ensure adequate responses to danger factors and thus promoting host defence against pathogens has been well described already for decades. Recently, numerous further reaching functions of complement have been discovered, among these are tissue homeostasis and regeneration, also with respect to the skeletal system. Read More

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http://dx.doi.org/10.1016/j.smim.2018.01.001DOI Listing
June 2018
4 Reads

Mesenchymal-myeloid interaction in the regulation of immunity.

Semin Immunol 2018 02 1;35:59-68. Epub 2018 Feb 1.

School of Cancer and Pharmacological Sciences and KHP Cancer Research UK Centre, King's College London, London, United Kingdom. Electronic address:

Several studies have demonstrated how different cell types of mesenchymal and myeloid origin can independently exhibit immunoregulatory activities. In response to inflammatory cues, they transcribe a molecular repertoire that restores the tissue microenvironment to what it was before the injury. There is accumulating evidence that stromal and myeloid-derived cells do not act independently but that the establishment of a cross-talk between them is a fundamental requirement. Read More

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http://dx.doi.org/10.1016/j.smim.2018.01.002DOI Listing
February 2018
3 Reads

Immune regulation by monocytes.

Authors:
Peter J Murray

Semin Immunol 2018 02 28;35:12-18. Epub 2017 Dec 28.

Immunoregulation Group, Max-Planck-Institut für Biochemie, Am Klopferspitz 18, 82152 Martinsried, Germany. Electronic address:

Monocytes emerging from the bone marrow are the progenitors of monocyte-derived macrophages. An essential function of monocytes is to seed tissues with sufficient macrophages to replace loss from infection and tissue damage. Recent work from diverse inflammatory and homeostatic settings has shown monocytes also possess direct protective and pathogenic activities. Read More

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http://dx.doi.org/10.1016/j.smim.2017.12.005DOI Listing
February 2018
4 Reads