2,736 results match your criteria Seminars in Cell and Developmental Biology [Journal]


Proteostasis: the network behind the networks.

Semin Cell Dev Biol 2019 Apr 17. Epub 2019 Apr 17.

CIC bioGUNE, Bilbao, Spain(1).

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http://dx.doi.org/10.1016/j.semcdb.2019.04.011DOI Listing

Microglial alterations induced by psychoactive drugs: A possible mechanism in substance use disorder?

Semin Cell Dev Biol 2019 Apr 17. Epub 2019 Apr 17.

Department of Dynamic and Clinical Psychology, University of Rome "La Sapienza," Via degli Apuli 1, 00185, Rome, Italy; IRCCS Santa Lucia Foundation, Via Fosso di Fiorano 64, 00143, Rome, Italy. Electronic address:

Recently, the xenobiotic hypothesis has implicated the immune system in targeting substances of abuse as foreign molecules and stimulating inflammatory responses. Microglial cells are the resident immune cells of the central nervous system and function in homeostatic surveillance. Microglial changes that are induced by exposure to substances of abuse appear to mediate in part the establishment of addiction and the persistence of drug-mediated biological and behavioral changes. Read More

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http://dx.doi.org/10.1016/j.semcdb.2019.03.008DOI Listing
April 2019
4 Reads

Precise editing of plant genomes - prospects and challenges.

Semin Cell Dev Biol 2019 Apr 16. Epub 2019 Apr 16.

Shanghai Center for Plant Stress Biology, Center for Excellence in Molecular Plant Sciences, Chinese Academy of Sciences, Shanghai, 200032, China. Electronic address:

The past decade has witnessed unprecedented development in genome engineering, a process that enables targeted modification of genomes. The identification of sequence-specific nucleases such as zinc-finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs) and the CRISPR/Cas system, in particular, has led to precise and efficient introduction of genetic variations into genomes of various organisms. Since the CRISPR/Cas system is highly versatile, cost-effective and much superior to ZFNs and TALENs, its widespread adoption by the research community has been inevitable. Read More

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http://dx.doi.org/10.1016/j.semcdb.2019.04.010DOI Listing
April 2019
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Spotlight on epigenetic reprogramming in cardiac regeneration.

Semin Cell Dev Biol 2019 Apr 16. Epub 2019 Apr 16.

Heart Failure and Cardiac Regeneration (ICREC) Research Program, Health Science Research Institute Germans Trias i Pujol (IGTP), Carretera Canyet, s/n, Camí de les Escoles, s/n, 08916 Badalona, Spain; CIBERCV, Instituto de Salud Carlos III, Av. de Monforte de Lemos, 5, 28029 Madrid, Spain; Cardiology Service, HUGTiP, Carretera Canyet, s/n, 08916 Badalona, Spain; Department of Medicine, Barcelona Autonomous University (UAB), Carretera Canyet, s/n, Camí de les Escoles, s/n, 08916 Badalona, Spain.

Heart failure of ischemic origin is caused by the presence of a large scar resulting from an acute myocardial infarction. Acute myocardial infarction generally occurs when blood supply to the heart is blocked. Regenerative strategies that limit infarct injury would be able to prevent adverse post-ischemic remodelling and maintain the structural support necessary for effective cardiomyocyte contraction. Read More

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http://dx.doi.org/10.1016/j.semcdb.2019.04.009DOI Listing
April 2019
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Chromatin dynamics underlying the precise regeneration of a vertebrate limb-epigenetic regulation and cellular memory.

Semin Cell Dev Biol 2019 Apr 13. Epub 2019 Apr 13.

Department of Biochemistry and Molecular Biology, Faculty of Agriculture and Life Science, Hirosaki University, 3 Bunkyo-cho, Hirosaki 036-8561, Japan. Electronic address:

Wound healing, tissue regeneration, and organ regrowth are all regeneration phenomena observed in vertebrates after an injury. However, the ability to regenerate differs greatly among species. Mammals can undergo wound healing and tissue regeneration, but cannot regenerate an organ; for example, they cannot regrow an amputated limb. Read More

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http://dx.doi.org/10.1016/j.semcdb.2019.04.006DOI Listing
April 2019
5 Reads

A CRISPR/Cas9 based polymeric nanoparticles to treat/inhibit microbial infections.

Semin Cell Dev Biol 2019 Apr 12. Epub 2019 Apr 12.

Department of Biological Sciences, College of Science Technology Engineering and Mathematics, Alabama State University, Montgomery, AL, 36104, USA. Electronic address:

The latest breakthrough towards the adequate and decisive methods of gene editing tools provided by CRISPR/Cas9 (Clustered Regularly Interspaced Short Palindromic Repeat/CRISPR Associated System), has been repurposed into a tool for genetically engineering eukaryotic cells and now considered as major innovation in gene related disorders. Nanotechnology has provided an alternate way to overcome the conventional problems where methods to deliver therapeutic agents have failed. The use of nanotechnology has the potential to safe-side the CRISPR/Cas9 components delivery by using customized polymeric nanoparticles for safety and efficacy. Read More

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http://dx.doi.org/10.1016/j.semcdb.2019.04.007DOI Listing
April 2019
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What Plant Roots Know?

Semin Cell Dev Biol 2019 Apr 8. Epub 2019 Apr 8.

Mitrani Department of Desert Ecology, The Swiss Institute for Dryland Environmental and Energy Research, The Jacob Blaustein Institutes for Desert Research, Ben-Gurion University of the Negev, Midreshet Ben-Gurion 8499000, Israel. Electronic address:

Despite their paramount role in plant life, the study of roots has been largely neglected until recently. Here, I shortly describe a few newly-discovered abilities of plants to undergo adaptive changes and execute developmental decisions based on roots' perception of non-resource information pertaining to imminent challenges and opportunities. Seemingly simple in their morphology and architecture and lacking central information-processing centres, roots are able to sense and integrate complex cues and signals over time and space that allow plants to perform elaborate behaviours analogous, some claim even homologous, to those of intelligent animals. Read More

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http://dx.doi.org/10.1016/j.semcdb.2019.03.009DOI Listing

Sound perception in plants.

Semin Cell Dev Biol 2019 Apr 6. Epub 2019 Apr 6.

School of Plant Sciences and Food Security, Tel-Aviv University, Tel-Aviv, Israel. Electronic address:

Can plants perceive sound? And what sounds are they likely to be "listening" to? The environment of plants includes many informative sounds, produced by biotic and abiotic sources. An ability to respond to these sounds could thus have a significant adaptive value for plants. We suggest the term phytoacoustics to describe the emerging field exploring sound emission and sound detection in plants, and review the recent studies published on these topics. Read More

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http://dx.doi.org/10.1016/j.semcdb.2019.03.006DOI Listing
April 2019
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Microglia immunometabolism: From metabolic disorders to single cell metabolism.

Semin Cell Dev Biol 2019 Apr 9. Epub 2019 Apr 9.

School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, 152-160 Pearse Street, D02 R590, Dublin, Ireland. Electronic address:

Since the observation that obesity-associated low-grade chronic inflammation is a crucial driver for the onset of systemic metabolic disorders such as type 2 diabetes, a number of studies have highlighted the role of both the innate and the adaptive immune system in such pathologies. Moreover, researchers have recently demonstrated that immune cells can modulate their intracellular metabolic profile to control their activation and effector functions. These discoveries represent the foundations of a research area known as "immunometabolism", an emerging field of investigation that may lead to the development of new-generation therapies for the treatment of inflammatory and metabolic diseases. Read More

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http://dx.doi.org/10.1016/j.semcdb.2019.03.012DOI Listing
April 2019
2 Reads

CRISPR-Cas based targeting of host and viral genes as an antiviral strategy.

Semin Cell Dev Biol 2019 Apr 8. Epub 2019 Apr 8.

Mucosal Immunology Lab, College of Dentistry, University of Illinois at Chicago, Chicago, IL, 60612, USA. Electronic address:

Viral infections in human are leading cause of mortality and morbidity across the globe. Several viruses (including HIV and Herpesvirus), have evolved ingenious strategies to evade host-immune system and persist life-long. Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and CRISPR-associated (Cas) is an ancient antiviral system recently discovered in bacteria that has shown tremendous potential as a precise, invariant genome editing tool. Read More

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http://dx.doi.org/10.1016/j.semcdb.2019.04.004DOI Listing

Regeneration enhancers: Starting a journey to unravel regulatory events in tissue regeneration.

Semin Cell Dev Biol 2019 Apr 8. Epub 2019 Apr 8.

Department of Cell and Regenerative Biology, School of Medicine and Public Health, University of Wisconsin - Madison, Madison, WI, 53705, USA. Electronic address:

Regeneration, an ability to replace lost body parts, is widespread across animal species. While mammals poorly regenerate most tissues, teleost fish and urodele amphibians possess remarkable regenerative capacity. Earlier work demonstrated that genes driving regeneration are evolutionarily conserved, indicating that a key factor in diverse tissue regeneration is not the presence or absence of regeneration-driving genes but the mechanisms controlling activation of these genes after injury. Read More

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http://dx.doi.org/10.1016/j.semcdb.2019.04.003DOI Listing
April 2019
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Editorial: Matrix Proteins.

Semin Cell Dev Biol 2019 May;89:99

Centre for Interdisciplinary Research in Biology (CIRB), Collège de France, CNRS UMR 7241, INSERM U1050, PSL University, Labex MemoLife, 75005 Paris, France.

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http://dx.doi.org/10.1016/j.semcdb.2019.03.001DOI Listing

The astrocyte biochemistry.

Semin Cell Dev Biol 2019 Apr 2. Epub 2019 Apr 2.

Graduate Program in Biological Sciences: Biochemistry, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil; Department of Pharmacology, UFRGS, Porto Alegre, Brazil; Graduate Program in Biological Sciences: Pharmacology and Therapeutics, UFRGS, Porto Alegre, Brazil; Brain Institute of Rio Grande do Sul (BraIns), Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Brazil. Electronic address:

Astrocytes are a unique and dynamic subtype of glial cells in the central nervous system (CNS). Understanding their biochemical reactions and their influence in the surrounding cells is extremely important in the neuroscience field. They exert important influence in the neurotransmission, ionic homeostasis and also release neuroactive molecules termed gliotransmitters. Read More

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http://dx.doi.org/10.1016/j.semcdb.2019.04.002DOI Listing
April 2019
2 Reads

Epigenetics in Neuronal Regeneration.

Semin Cell Dev Biol 2019 Apr 2. Epub 2019 Apr 2.

Department of Biological Structure, Molecular and Cellular Biology Graduate Program, Institute for Stem Cells and Regenerative Medicine, University of Washington, School of Medicine, Seattle, WA 98195, United States. Electronic address:

Damage to neuronal tissues in mammals leads to permanent loss of tissue function that can have major health consequences. While mammals have no inherent regenerative capacity to functionally repair neuronal tissue, other species such as amphibians and teleost fish readily replace damaged tissue. The exploration of development and native regeneration can thus inform the process of inducing regeneration in non-regenerative systems, which can be used to develop new therapeutics. Read More

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http://dx.doi.org/10.1016/j.semcdb.2019.04.001DOI Listing
April 2019
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The potential application of genome editing by using CRISPR/Cas9, and its engineered and ortholog variants for studying the transcription factors involved in the maintenance of phosphate homeostasis in model plants.

Semin Cell Dev Biol 2019 Apr 6. Epub 2019 Apr 6.

Amity Institute of Biotechnology, Amity University Rajasthan, Jaipur, India. Electronic address:

Phosphorus (P), an essential macronutrient, is pivotal for growth and development of plants. Availability of phosphate (Pi), the only assimilable P, is often suboptimal in rhizospheres. Pi deficiency triggers an array of spatiotemporal adaptive responses including the differential regulation of several transcription factors (TFs). Read More

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http://dx.doi.org/10.1016/j.semcdb.2019.03.010DOI Listing

Plant photoreceptors: Multi-functional sensory proteins and their signaling networks.

Semin Cell Dev Biol 2019 Apr 3. Epub 2019 Apr 3.

Department of Molecular Biosciences and The Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, TX, 78712, United States. Electronic address:

Light is a crucial environmental cue not only for photosynthetic energy production but also for plant growth and development. Plants employ sophisticated methods to detect and interpret information from incoming light. Five classes of photoreceptors have been discovered in the model plant Arabidopsis thaliana. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10849521173057
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http://dx.doi.org/10.1016/j.semcdb.2019.03.007DOI Listing
April 2019
2 Reads

Chromatin dynamics during liver regeneration.

Semin Cell Dev Biol 2019 Apr 9. Epub 2019 Apr 9.

Hepatology Program, CIMA, University of Navarra, Pamplona, Spain; CIBERehd, Instituto de Salud Carlos III, Madrid, Spain; Instituto de Investigaciones Sanitarias de Navarra-IdiSNA, Pamplona, Spain. Electronic address:

Liver regeneration is the most important reaction of the liver to an injury. Indeed, the liver possesses an extraordinary regenerative capacity orchestrated by a highly coordinated response of all the different cell types in order to recover the tissue lost, while maintaining homeostasis and all the hepatic functions. To achieve this impressive physiological accomplishment, the liver experiences a transient but precisely controlled transcriptional reprogramming that allows the simultaneous activation and silencing of multiple genes at different stages of the regeneration process. Read More

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http://dx.doi.org/10.1016/j.semcdb.2019.03.004DOI Listing
April 2019
2 Reads

What do plants really know?

Semin Cell Dev Biol 2019 Apr 2. Epub 2019 Apr 2.

Ben-Gurion University of the Negev, Israel. Electronic address:

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http://dx.doi.org/10.1016/j.semcdb.2019.03.005DOI Listing

Plant responses to gravity.

Semin Cell Dev Biol 2019 Apr 2. Epub 2019 Apr 2.

Department of Biology, University of North Carolina at Greensboro, Greensboro, NC, 27412, USA. Electronic address:

Tropisms are directed growth-mediated plant movements which allow plants to respond to their environment. Gravitropism is the ability of plants to perceive and respond to the gravity vector and orient themselves accordingly. The gravitropic pathway can be divided into three main components: perception, biochemical signaling, and differential growth. Read More

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http://dx.doi.org/10.1016/j.semcdb.2019.03.011DOI Listing

Mesenchymal stem cell therapies in brain disease.

Semin Cell Dev Biol 2019 Apr 3. Epub 2019 Apr 3.

Division of Hematology/Oncology, Department of Medicine, New Jersey Medical School, Rutgers Biomedical and Health Sciences, Newark, NJ, USA. Electronic address:

As treatments for diseases throughout the body progress, treatment for many brain diseases has been at a standstill due to difficulties in drug delivery. While new drugs are being discovered in vitro, these therapies are often hindered by inefficient tissue distribution and, more commonly, an inability to cross the blood brain barrier. Mesenchymal stem cells are thus being investigated as a delivery tool to directly target therapies to the brain to treat wide array of brain diseases. Read More

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http://dx.doi.org/10.1016/j.semcdb.2019.03.003DOI Listing
April 2019
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Brain organoids as a model system for human neurodevelopment and disease.

Semin Cell Dev Biol 2019 Mar 22. Epub 2019 Mar 22.

University of California San Diego, School of Medicine, Department of Pediatrics/Rady Children's Hospital San Diego, La Jolla, CA, 92093, USA; University of California San Diego, Kavli Institute for Brain and Mind, La Jolla, CA, 92093, USA; Center for Academic Research and Training in Anthropogeny (CARTA), La Jolla, CA, 92093, USA. Electronic address:

The ability to reproduce early stages of human neurodevelopment in the laboratory is one of the most exciting fields in modern neuroscience. The inaccessibility of the healthy human brain developing in utero has delayed our understanding of the initial steps in the formation of one of the most complex tissues in the body. Animal models, postmortem human tissues and cellular systems have been instrumental in contributing to our understanding of the human brain. Read More

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http://dx.doi.org/10.1016/j.semcdb.2019.03.002DOI Listing
March 2019
9 Reads

Rod microglia and their role in neurological diseases.

Semin Cell Dev Biol 2019 Mar 8. Epub 2019 Mar 8.

Wicking Dementia Research and Education Centre, College of Health and Medicine, University of Tasmania, Hobart, Tasmania, 7000, Australia. Electronic address:

The striking morphology of microglia is one of their most prominent characteristics, with many studies categorising microglial function based on morphology e.g. ramified, hyper-ramified, activated, or amoeboid. Read More

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http://dx.doi.org/10.1016/j.semcdb.2019.02.005DOI Listing

Synaptic vesicle protein 2: A multi-faceted regulator of secretion.

Semin Cell Dev Biol 2019 Mar 20. Epub 2019 Mar 20.

Department of Pharmacology, University of Washington, Seattle, WA, United States. Electronic address:

Synaptic Vesicle Protein 2 (SV2) comprises a recently evolved family of proteins unique to secretory vesicles that undergo calcium-regulated exocytosis. In this review we consider SV2s' structural features, evolution, and function and discuss its therapeutic potential as the receptors for an expanding class of drugs used to treat epilepsy and cognitive decline. Read More

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http://dx.doi.org/10.1016/j.semcdb.2019.02.003DOI Listing
March 2019
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Functional multipotency of stem cells: Biological traits gleaned from neural progeny studies.

Authors:
Yang D Teng

Semin Cell Dev Biol 2019 Mar 13. Epub 2019 Mar 13.

Department of Physical Medicine & Rehabilitation, Harvard Medical School and Spaulding Rehabilitation Hospital Network, Boston, MA, USA; Department of Neurosurgery, Harvard Medical School and Brigham & Women's Hospital, Boston, MA, USA; Division of SCI Research, Veterans Affairs Boston Healthcare System, Boston, MA, USA. Electronic address:

In this review, a stem cell concept, initially defined by the author more than 10 years ago focusing on neural stem cells, has been systematically refined and updated. Relative to the conventional view which touched principally on the totipotency, pluripotentcy and multipotency of cell lineage differentiation (e.g. Read More

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http://dx.doi.org/10.1016/j.semcdb.2019.02.002DOI Listing
March 2019
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What do plants really know?

Semin Cell Dev Biol 2019 Feb 26. Epub 2019 Feb 26.

Ben-Gurion University of the Negev, Israel. Electronic address:

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http://dx.doi.org/10.1016/j.semcdb.2019.02.004DOI Listing
February 2019

TRPC-mediated Ca signaling and control of cellular functions.

Semin Cell Dev Biol 2019 Mar 1. Epub 2019 Mar 1.

Gottfried-Schatz-Research-Center - Biophysics, Medical University of Graz, Neue Stiftingtalstrasse 6/D04, 8010, Graz, Austria. Electronic address:

Canonical members of the TRP superfamily of ion channels have long been recognized as key elements of Ca handling in a plethora of cell types. The emerging role of TRPC channels in human physiopathology has generated considerable interest in their pharmacological targeting, which requires detailed understanding of their molecular function. Although consent has been reached that receptor-phospholipase C (PLC) pathways and generation of lipid mediators constitute the prominent upstream signaling process that governs channel activity, multimodal sensing features of TRPC complexes have been demonstrated repeatedly. Read More

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http://dx.doi.org/10.1016/j.semcdb.2019.02.001DOI Listing

Spatial-temporal patterning of Ca signals by the subcellular distribution of IP and IP receptors.

Semin Cell Dev Biol 2019 Feb 2. Epub 2019 Feb 2.

Department of Neurobiology & Behavior, UC Irvine, Irvine, CA, USA; Department of Physiology & Biophysics, UC Irvine, Irvine, CA, USA.

The patterning of cytosolic Ca signals in space and time underlies their ubiquitous ability to specifically regulate numerous cellular processes. Signals mediated by liberation of Ca sequestered in the endoplasmic reticulum (ER) through inositol trisphosphate receptor (IPR) channels constitute a hierarchy of events; ranging from openings of individual IP channels, through the concerted openings of several clustered IPRs to generate local Ca puffs, to global Ca waves and oscillations that engulf the entire cell. Here, we review recent progress in elucidating how this hierarchy is shaped by an interplay between the functional gating properties of IPRs and their spatial distribution within the cell. Read More

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http://dx.doi.org/10.1016/j.semcdb.2019.01.012DOI Listing
February 2019
6 Reads

Plasticity of microglia in remote regions after focal brain injury.

Semin Cell Dev Biol 2019 Feb 2. Epub 2019 Feb 2.

Fondazione Policlinico Universitario A. Gemelli, Università Cattolica del S. Cuore, Rome, Italy. Electronic address:

The CNS is endowed with an intrinsic ability to recover from and adapt secondary compensatory mechanisms to injury. The basis of recovery stems from brain plasticity, defined as the brain's ability to make adaptive changes on structural and functional levels, ranging from molecular, synaptic, and cellular changes in response to alterations in their environment. In this multitude of responses, microglia have an active role and contribute to brain plasticity through their dynamic responses. Read More

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http://dx.doi.org/10.1016/j.semcdb.2019.01.011DOI Listing
February 2019
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Coding and decoding of oscillatory Ca signals.

Semin Cell Dev Biol 2019 Jan 24. Epub 2019 Jan 24.

Unit of Theoretical Chronobiology, Faculté des Sciences, Université Libre de Bruxelles (ULB), Brussels, Belgium. Electronic address:

About 30 years after their first observation, Ca oscillations are now recognised as a universal mechanism of signal transduction. These oscillations are driven by periodic cycles of release and uptake of Ca between the cytoplasm and the endoplasmic reticulum. Their frequency often increases with the level of stimulation, which can be decoded by some molecules. Read More

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http://dx.doi.org/10.1016/j.semcdb.2019.01.008DOI Listing
January 2019
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Pre-synaptic sympathetic calcium channels, cyclic nucleotide-coupled phosphodiesterases and cardiac excitability.

Semin Cell Dev Biol 2019 Jan 23. Epub 2019 Jan 23.

Burdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, Sherrington Building, University of Oxford, Parks Road, Oxford, OX1 3PT, UK. Electronic address:

In sympathetic neurons innervating the heart, action potentials activate voltage-gated Ca channels and evoke Ca entry into presynaptic terminals triggering neurotransmitter release. Binding of transmitters to specific receptors stimulates signal transduction pathways that cause changes in cardiac function. The mechanisms contributing to presynaptic Ca dynamics involve regulation of endogenous Ca buffers, in particular the endoplasmic reticulum, mitochondria and cyclic nucleotide targeted pathways. Read More

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http://dx.doi.org/10.1016/j.semcdb.2019.01.010DOI Listing
January 2019
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Functional properties and mode of regulation of the mitochondrial Na/Ca exchanger, NCLX.

Semin Cell Dev Biol 2019 Jan 29. Epub 2019 Jan 29.

Department of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, 84105, Israel. Electronic address:

Mitochondrial Ca transient is the earliest discovered organellar Ca signaling pathway. It consist of a Ca influx, mediated by mitochondrial Ca uniporter (MCU), and mitochondrial Ca efflux mediated by a Na/Ca exchanger (NCLX). Mitochondrial Ca signaling machinery plays a fundamental role in linking metabolic activity to cellular Ca signaling, and in controlling local Ca concertation in distinct cellular compartments. Read More

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http://dx.doi.org/10.1016/j.semcdb.2019.01.009DOI Listing
January 2019
4 Reads

Mechanistic insights into the Orai channel by molecular dynamics simulations.

Semin Cell Dev Biol 2019 Jan 15. Epub 2019 Jan 15.

Gottfried Schatz Research Center, Medical University of Graz, A-8010 Graz, Austria. Electronic address:

Highly Ca selective channels trigger a large variety of cellular signaling processes in both excitable and non-excitable cells. Among these channels, the Orai channel is unique in its activation mechanism and its structure. It mediates Ca influx into the cytosol with an extremely small unitary conductance over longer time-scales, ranging from minutes up to several hours. Read More

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http://dx.doi.org/10.1016/j.semcdb.2019.01.002DOI Listing
January 2019
2 Reads
6.265 Impact Factor

Neural stem cell niche heterogeneity.

Semin Cell Dev Biol 2019 Jan 14. Epub 2019 Jan 14.

Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil; Department of Radiology, Columbia University Medical Center, New York, NY, USA. Electronic address:

In mammals, new neurons can be generated from neural stem cells in specific regions of the adult brain. Neural stem cells are characterized by their abilities to differentiate into all neural lineages and to self-renew. The specific microenvironments regulating neural stem cells, commonly referred to as neurogenic niches, comprise multiple cell populations whose precise contributions are under active current exploration. Read More

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http://dx.doi.org/10.1016/j.semcdb.2019.01.005DOI Listing
January 2019
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Microglia: Neuroimmune-sensors of stress.

Semin Cell Dev Biol 2019 Jan 8. Epub 2019 Jan 8.

Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, 80309, USA; Center for Neuroscience, University of Colorado Boulder, Boulder, CO, 80309, USA.

Exposure to stressors disrupts homeostasis and results in the release of stress hormones including glucocorticoids, epinepherine and norepinepherine. Interestingly, stress also has profound affects on microglia, which are tissue-resident macrophages in the brain parenchyma. Microglia express a diverse array of receptors, which also allows them to respond to stress hormones derived from peripheral as well as central sources. Read More

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http://dx.doi.org/10.1016/j.semcdb.2019.01.001DOI Listing
January 2019
2 Reads

From membrane receptors to protein synthesis and actin cytoskeleton: Mechanisms underlying long lasting forms of synaptic plasticity.

Semin Cell Dev Biol 2019 Jan 11. Epub 2019 Jan 11.

George Mason University, Department of Bioengineering and Krasnow Institute for Advanced Study, MS 2A1, Fairfax, VA, 22030-4444, United States. Electronic address:

Synaptic plasticity, the activity dependent change in synaptic strength, forms the molecular foundation of learning and memory. Synaptic plasticity includes structural changes, with spines changing their size to accomodate insertion and removal of postynaptic receptors, which are correlated with functional changes. Of particular relevance for memory storage are the long lasting forms of synaptic plasticity which are protein synthesis dependent. Read More

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http://dx.doi.org/10.1016/j.semcdb.2019.01.006DOI Listing
January 2019
9 Reads

Regulation of temporal properties of neural stem cells and transition timing of neurogenesis and gliogenesis during mammalian neocortical development.

Semin Cell Dev Biol 2019 Jan 17. Epub 2019 Jan 17.

Institute for Frontier Life and Medical Sciences, Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan; Kyoto University Graduate School of Medicine, Kyoto, 606-8501, Japan; Kyoto University Graduate School of Biostudies, Kyoto, 606-8501, Japan; Institute for Integrated Cell-Material Sciences (iCeMS), Kyoto University, Kyoto, 606-8501, Japan.

In the developing mammalian neocortex, neural stem cells (NSCs) gradually alter their characteristics as development proceeds. NSCs initially expand the progenitor pool by symmetric proliferative division and then shift to asymmetric neurogenic division to commence neurogenesis. NSCs sequentially give rise to deep layer neurons first and superficial layer neurons later through mid- to late-embryonic stages, followed by shifting to a gliogenic phase at perinatal stages. Read More

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http://dx.doi.org/10.1016/j.semcdb.2019.01.007DOI Listing
January 2019
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Store-operated calcium entry in disease: Beyond STIM/Orai expression levels.

Semin Cell Dev Biol 2019 Jan 11. Epub 2019 Jan 11.

Institute of Biochemistry and Molecular Medicine, National Center of Competence in Research NCCR TransCure, University of Bern, Bühlstrasse 28, 3012 Bern, Switzerland. Electronic address:

Precise intracellular calcium signaling is crucial to numerous cellular functions. In non-excitable cells, store-operated calcium entry (SOCE) is a key step in the generation of intracellular calcium signals. Tight regulation of SOCE is important, and dysregulation is involved in several pathophysiological cellular malfunctions. Read More

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http://dx.doi.org/10.1016/j.semcdb.2019.01.003DOI Listing
January 2019
2 Reads

Calcium signal dynamics in T lymphocytes: Comparing in vivo and in vitro measurements.

Semin Cell Dev Biol 2019 Jan 10. Epub 2019 Jan 10.

Department of Biophysics, Center for Integrative Physiology and Molecular Medicine, Medical Faculty, Saarland University, Homburg, Germany. Electronic address:

Amplitude and kinetics of intracellular Ca signals ([Ca]) determine many immune cell functions. To mimic in vivo changes of [Ca] in human immune cells, two approaches may be best suited: 1) Analyze primary human immune cells taken from blood under conditions resembling best physiological or pathophysiological conditions. 2. Read More

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http://dx.doi.org/10.1016/j.semcdb.2019.01.004DOI Listing
January 2019
1 Read

Cullin 3, a cellular scripter of the non-proteolytic ubiquitin code.

Semin Cell Dev Biol 2018 Dec 28. Epub 2018 Dec 28.

Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Illkirch, France; Centre National de la Recherche Scientifique UMR 7104, Strasbourg, France; Institut National de la Santé et de la Recherche Médicale U964, Strasbourg, France; Université de Strasbourg, Strasbourg, France. Electronic address:

Cullin-RING ubiquitin ligases (CRLs) represent the largest family of E3 ubiquitin ligases that control most if not all cellular processes. In CUL3-based CRLs, the substrate specificity is conferred by the interaction with one of around 183 existing BTB proteins, implying a broad spectrum of possible ubiquitylation signals and possible direct ubiquitylation substrates. Indeed, CUL3-based E3-ligases can catalyze various proteolytic and non-proteolytic ubiquitin signals regulating many physiological and pathophysiological states. Read More

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http://dx.doi.org/10.1016/j.semcdb.2018.12.007DOI Listing
December 2018
15 Reads

Decoding epigenetic cell signaling in neuronal differentiation.

Semin Cell Dev Biol 2019 Jan 24. Epub 2019 Jan 24.

Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil; Instituto Nanocell, Divinópolis, MG, Brazil. Electronic address:

Neurogenesis is the process by which new neurons are generated in the brain. Neural stem cells (NSCs) are differentiated into neurons, which are integrated into the neural network. Nowadays, pluripotent stem cells, multipotent stem cells, and induced pluripotent stem cells can be artificially differentiated into neurons utilizing several techniques. Read More

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http://dx.doi.org/10.1016/j.semcdb.2018.12.006DOI Listing
January 2019
3 Reads

When ubiquitin meets E-cadherin: Plasticity of the epithelial cellular barrier.

Semin Cell Dev Biol 2018 Dec 19. Epub 2018 Dec 19.

IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Via Adamello 16, Milan 20139, Italy; Dipartimento di oncologia ed emato-oncologia, Universita' degli Studi di Milano, Via Santa Sofia 9/1, Milan 20122, Italy. Electronic address:

Cellular plasticity is, by definition, the ability of cells to adapt to a dynamic micro-environment by changing their phenotype. E-cadherin is the key organizer of the epithelial cell barrier, and it is required at the cell surface to preserve epithelial tissue integrity and homeostasis, since it not only organizes the adherens junctions, but also transfers intracellular signals that provide cues to regulate cell survival, morphology and polarity. As such, de-regulation of E-cadherin has deleterious effects on cells and whole tissues. Read More

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http://dx.doi.org/10.1016/j.semcdb.2018.12.005DOI Listing
December 2018
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The role of neurogenesis in neurorepair after ischemic stroke.

Semin Cell Dev Biol 2019 Jan 18. Epub 2019 Jan 18.

Departamento de Farmacologia, Instituto de Ciências Biológicas, Universidade Federal de Goiás, Goiânia, Brazil. Electronic address:

Stroke consists of an abrupt reduction of cerebral blood flow resulting in hypoxia that triggers an excitotoxicity, oxidative stress, and neuroinflammation. After the ischemic process, neural precursor cells present in the subventricular zone of the lateral ventricle and subgranular zone of the dentate gyrus proliferate and migrate towards the lesion, contributing to the brain repair. The neurogenesis is induced by signal transduction pathways, growth factors, attractive factors for neuroblasts, transcription factors, pro and anti-inflammatory mediators and specific neurotransmissions. Read More

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http://dx.doi.org/10.1016/j.semcdb.2018.12.003DOI Listing
January 2019
21 Reads

Calcium signalling: A common target in neurological disorders and neurogenesis.

Semin Cell Dev Biol 2018 Dec 13. Epub 2018 Dec 13.

Department of Biochemistry, IQ, University of Sao Paulo, Sao Paulo, Brazil. Electronic address:

Calcium is an ubiquitous second messenger used by any living cell. The fine-tuning of intracellular free calcium concentration ([Ca]) homeostasis and signalling pathways is crucial for the maintenance of the healthy organism. Many alterations in the homeostasis can be compensated by robust mechanisms; however, cells that already present some debility in those mechanisms, or that are over stimulated cannot compensate the stress and die. Read More

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http://dx.doi.org/10.1016/j.semcdb.2018.12.002DOI Listing
December 2018
5 Reads

Editorial.

Semin Cell Dev Biol 2018 Dec 19. Epub 2018 Dec 19.

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http://dx.doi.org/10.1016/j.semcdb.2018.12.004DOI Listing
December 2018
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Purinergic signalling and brain development.

Semin Cell Dev Biol 2018 Dec 4. Epub 2018 Dec 4.

CNC - Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504, Coimbra, Portugal; Faculty of Medicine, University of Coimbra, Coimbra, 3004-504, Portugal.

ATP and adenosine are released from cells as a function of their metabolic activity, being important cell-to-cell communication signals. Both purines are also released from neurons in an activity-dependent manner, with several established roles to fine tune brain function in adults, as best heralded by the effects of caffeine, an antagonist of adenosine receptors. Purines are also dynamically released from early neurogenesis and different purine receptors are dynamically expressed throughout development. Read More

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http://dx.doi.org/10.1016/j.semcdb.2018.12.001DOI Listing
December 2018
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Signaling within the pineal gland: A parallelism with the central nervous system.

Semin Cell Dev Biol 2018 Nov 30. Epub 2018 Nov 30.

Institute of Histology and Embryology of Mendoza (IHEM), National University of Cuyo, National Scientific and Technical Research Council (CONICET), Mendoza, Argentina. Electronic address:

The pineal gland (PG) derives from the neural tube, like the rest of the central nervous system (CNS). The PG is specialized in synthesizing and secreting melatonin in a circadian fashion. The nocturnal elevation of melatonin is a highly conserved feature among species which proves its importance in nature. Read More

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http://dx.doi.org/10.1016/j.semcdb.2018.11.004DOI Listing
November 2018
5 Reads

MR1-dependent antigen presentation.

Semin Cell Dev Biol 2018 12;84:58-64

Pulmonary & Critical Care Medicine, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA; Portland VA Medical Center, 3710 SW US Veterans Hospital Road, Portland, OR 97239, USA; Molecular Microbiology and Immunology, Oregon Health & Science University, 3181 SW Sam Jackson Park Road. Portland, OR 97239, USA. Electronic address:

MR1 is a non-classical class I molecule that is highly conserved among mammals. Though discovered in 1995, only recently have MR1 ligands and antigens for MR1-restricted T cells been described. Unlike the traditional class I molecules HLA-A, -B, and -C, little MR1 is on the cell surface. Read More

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http://dx.doi.org/10.1016/j.semcdb.2017.11.028DOI Listing
December 2018
9 Reads

The intersection of affinity and specificity in the development and optimization of T cell receptor based therapeutics.

Semin Cell Dev Biol 2018 12;84:30-41

Department of Chemistry and Biochemistry and the Harper Cancer Research Institute, University of Notre Dame, 251 Nieuwland Science Hall, Notre Dame, IN 46556 USA. Electronic address:

The role of the αβ T cell receptor (TCR) in identifying immunological targets and signaling appropriate responses provides for exciting translational opportunities. Yet TCRs mediate one of the most complex protein-protein interactions in biology, with intricate signaling and selection mechanisms adding additional layers of sophistication. In this review, we discuss how these complexities influence the development and optimization of TCR-based therapeutics, focusing on the intersection between structure, affinity, and specificity. Read More

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http://dx.doi.org/10.1016/j.semcdb.2017.10.017DOI Listing
December 2018
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The use of proteomics to understand antiviral immunity.

Semin Cell Dev Biol 2018 12 8;84:22-29. Epub 2018 Oct 8.

Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia. Electronic address:

Viruses are intracellular pathogens that cause a vast array of diseases, which are often severe and typified by high morbidity and mortality rates. Viral infections continue to be a global health burden and effective vaccines and therapeutics are constantly sought to prevent and treat these infections. The development of such treatments generally relies on understanding the mechanisms that underpin efficient host antiviral immune responses. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10849521163045
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http://dx.doi.org/10.1016/j.semcdb.2017.12.002DOI Listing
December 2018
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Seminars in cell and developmental biology.

Semin Cell Dev Biol 2018 Nov 22. Epub 2018 Nov 22.

Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.semcdb.2018.11.003DOI Listing
November 2018
2 Reads