2,711 results match your criteria Seminars in Cell and Developmental Biology [Journal]


TRPC-mediated Ca signaling and control of cellular functions.

Semin Cell Dev Biol 2019 Feb 7. Epub 2019 Feb 7.

Gottfried-Schatz-Research-Center - Biophysics, Medical University of Graz, Neue Stiftingtalstrasse 6/D04, 8010, Graz, Austria. Electronic address:

Canonical members of the TRP superfamily of ion channels have long been recognized as key elements of Ca handling in a plethora of cell types. The emerging role of TRPC channels in human physiopathology has generated considerable interest in their pharmacological targeting, which requires detailed understanding of their molecular function. Although consent has been reached that receptor-phospholipase C (PLC) pathways and generation of lipid mediators constitute the prominent upstream signaling process that governs channel activity, multimodal sensing features of TRPC complexes have been demonstrated repeatedly. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.semcdb.2019.02.001DOI Listing
February 2019

Spatial-temporal patterning of Ca signals by the subcellular distribution of IP and IP receptors.

Semin Cell Dev Biol 2019 Feb 2. Epub 2019 Feb 2.

Department of Neurobiology & Behavior, UC Irvine, Irvine, CA, USA; Department of Physiology & Biophysics, UC Irvine, Irvine, CA, USA.

The patterning of cytosolic Ca signals in space and time underlies their ubiquitous ability to specifically regulate numerous cellular processes. Signals mediated by liberation of Ca sequestered in the endoplasmic reticulum (ER) through inositol trisphosphate receptor (IPR) channels constitute a hierarchy of events; ranging from openings of individual IP channels, through the concerted openings of several clustered IPRs to generate local Ca puffs, to global Ca waves and oscillations that engulf the entire cell. Here, we review recent progress in elucidating how this hierarchy is shaped by an interplay between the functional gating properties of IPRs and their spatial distribution within the cell. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.semcdb.2019.01.012DOI Listing
February 2019
1 Read

Plasticity of microglia in remote regions after focal brain injury.

Semin Cell Dev Biol 2019 Feb 2. Epub 2019 Feb 2.

Fondazione Policlinico Universitario A. Gemelli, Università Cattolica del S. Cuore, Rome, Italy. Electronic address:

The CNS is endowed with an intrinsic ability to recover from and adapt secondary compensatory mechanisms to injury. The basis of recovery stems from brain plasticity, defined as the brain's ability to make adaptive changes on structural and functional levels, ranging from molecular, synaptic, and cellular changes in response to alterations in their environment. In this multitude of responses, microglia have an active role and contribute to brain plasticity through their dynamic responses. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.semcdb.2019.01.011DOI Listing
February 2019
1 Read

Coding and decoding of oscillatory Ca signals.

Semin Cell Dev Biol 2019 Jan 24. Epub 2019 Jan 24.

Unit of Theoretical Chronobiology, Faculté des Sciences, Université Libre de Bruxelles (ULB), Brussels, Belgium. Electronic address:

About 30 years after their first observation, Ca oscillations are now recognised as a universal mechanism of signal transduction. These oscillations are driven by periodic cycles of release and uptake of Ca between the cytoplasm and the endoplasmic reticulum. Their frequency often increases with the level of stimulation, which can be decoded by some molecules. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.semcdb.2019.01.008DOI Listing
January 2019
1 Read

Pre-synaptic sympathetic calcium channels, cyclic nucleotide-coupled phosphodiesterases and cardiac excitability.

Semin Cell Dev Biol 2019 Jan 23. Epub 2019 Jan 23.

Burdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, Sherrington Building, University of Oxford, Parks Road, Oxford, OX1 3PT, UK. Electronic address:

In sympathetic neurons innervating the heart, action potentials activate voltage-gated Ca channels and evoke Ca entry into presynaptic terminals triggering neurotransmitter release. Binding of transmitters to specific receptors stimulates signal transduction pathways that cause changes in cardiac function. The mechanisms contributing to presynaptic Ca dynamics involve regulation of endogenous Ca buffers, in particular the endoplasmic reticulum, mitochondria and cyclic nucleotide targeted pathways. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.semcdb.2019.01.010DOI Listing
January 2019
1 Read

Functional properties and mode of regulation of the mitochondrial Na/Ca exchanger, NCLX.

Semin Cell Dev Biol 2019 Jan 29. Epub 2019 Jan 29.

Department of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, 84105, Israel. Electronic address:

Mitochondrial Ca transient is the earliest discovered organellar Ca signaling pathway. It consist of a Ca influx, mediated by mitochondrial Ca uniporter (MCU), and mitochondrial Ca efflux mediated by a Na/Ca exchanger (NCLX). Mitochondrial Ca signaling machinery plays a fundamental role in linking metabolic activity to cellular Ca signaling, and in controlling local Ca concertation in distinct cellular compartments. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.semcdb.2019.01.009DOI Listing
January 2019
1 Read

Mechanistic insights into the Orai channel by molecular dynamics simulations.

Semin Cell Dev Biol 2019 Jan 15. Epub 2019 Jan 15.

Gottfried Schatz Research Center, Medical University of Graz, A-8010 Graz, Austria. Electronic address:

Highly Ca selective channels trigger a large variety of cellular signaling processes in both excitable and non-excitable cells. Among these channels, the Orai channel is unique in its activation mechanism and its structure. It mediates Ca influx into the cytosol with an extremely small unitary conductance over longer time-scales, ranging from minutes up to several hours. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.semcdb.2019.01.002DOI Listing
January 2019
2 Reads
6.265 Impact Factor

Neural stem cell niche heterogeneity.

Semin Cell Dev Biol 2019 Jan 14. Epub 2019 Jan 14.

Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil; Department of Radiology, Columbia University Medical Center, New York, NY, USA. Electronic address:

In mammals, new neurons can be generated from neural stem cells in specific regions of the adult brain. Neural stem cells are characterized by their abilities to differentiate into all neural lineages and to self-renew. The specific microenvironments regulating neural stem cells, commonly referred to as neurogenic niches, comprise multiple cell populations whose precise contributions are under active current exploration. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.semcdb.2019.01.005DOI Listing
January 2019
1 Read

Microglia: Neuroimmune-sensors of stress.

Semin Cell Dev Biol 2019 Jan 8. Epub 2019 Jan 8.

Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, 80309, USA; Center for Neuroscience, University of Colorado Boulder, Boulder, CO, 80309, USA.

Exposure to stressors disrupts homeostasis and results in the release of stress hormones including glucocorticoids, epinepherine and norepinepherine. Interestingly, stress also has profound affects on microglia, which are tissue-resident macrophages in the brain parenchyma. Microglia express a diverse array of receptors, which also allows them to respond to stress hormones derived from peripheral as well as central sources. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.semcdb.2019.01.001DOI Listing
January 2019
2 Reads

From membrane receptors to protein synthesis and actin cytoskeleton: Mechanisms underlying long lasting forms of synaptic plasticity.

Semin Cell Dev Biol 2019 Jan 11. Epub 2019 Jan 11.

George Mason University, Department of Bioengineering and Krasnow Institute for Advanced Study, MS 2A1, Fairfax, VA, 22030-4444, United States. Electronic address:

Synaptic plasticity, the activity dependent change in synaptic strength, forms the molecular foundation of learning and memory. Synaptic plasticity includes structural changes, with spines changing their size to accomodate insertion and removal of postynaptic receptors, which are correlated with functional changes. Of particular relevance for memory storage are the long lasting forms of synaptic plasticity which are protein synthesis dependent. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10849521183005
Publisher Site
http://dx.doi.org/10.1016/j.semcdb.2019.01.006DOI Listing
January 2019
5 Reads

Regulation of temporal properties of neural stem cells and transition timing of neurogenesis and gliogenesis during mammalian neocortical development.

Semin Cell Dev Biol 2019 Jan 17. Epub 2019 Jan 17.

Institute for Frontier Life and Medical Sciences, Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan; Kyoto University Graduate School of Medicine, Kyoto, 606-8501, Japan; Kyoto University Graduate School of Biostudies, Kyoto, 606-8501, Japan; Institute for Integrated Cell-Material Sciences (iCeMS), Kyoto University, Kyoto, 606-8501, Japan.

In the developing mammalian neocortex, neural stem cells (NSCs) gradually alter their characteristics as development proceeds. NSCs initially expand the progenitor pool by symmetric proliferative division and then shift to asymmetric neurogenic division to commence neurogenesis. NSCs sequentially give rise to deep layer neurons first and superficial layer neurons later through mid- to late-embryonic stages, followed by shifting to a gliogenic phase at perinatal stages. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.semcdb.2019.01.007DOI Listing
January 2019
1 Read

Store-operated calcium entry in disease: Beyond STIM/Orai expression levels.

Semin Cell Dev Biol 2019 Jan 11. Epub 2019 Jan 11.

Institute of Biochemistry and Molecular Medicine, National Center of Competence in Research NCCR TransCure, University of Bern, Bühlstrasse 28, 3012 Bern, Switzerland. Electronic address:

Precise intracellular calcium signaling is crucial to numerous cellular functions. In non-excitable cells, store-operated calcium entry (SOCE) is a key step in the generation of intracellular calcium signals. Tight regulation of SOCE is important, and dysregulation is involved in several pathophysiological cellular malfunctions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.semcdb.2019.01.003DOI Listing
January 2019
1 Read

Calcium signal dynamics in T lymphocytes: Comparing in vivo and in vitro measurements.

Semin Cell Dev Biol 2019 Jan 10. Epub 2019 Jan 10.

Department of Biophysics, Center for Integrative Physiology and Molecular Medicine, Medical Faculty, Saarland University, Homburg, Germany. Electronic address:

Amplitude and kinetics of intracellular Ca signals ([Ca]) determine many immune cell functions. To mimic in vivo changes of [Ca] in human immune cells, two approaches may be best suited: 1) Analyze primary human immune cells taken from blood under conditions resembling best physiological or pathophysiological conditions. 2. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.semcdb.2019.01.004DOI Listing
January 2019
1 Read

Cullin 3, a cellular scripter of the non-proteolytic ubiquitin code.

Semin Cell Dev Biol 2018 Dec 28. Epub 2018 Dec 28.

Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Illkirch, France; Centre National de la Recherche Scientifique UMR 7104, Strasbourg, France; Institut National de la Santé et de la Recherche Médicale U964, Strasbourg, France; Université de Strasbourg, Strasbourg, France. Electronic address:

Cullin-RING ubiquitin ligases (CRLs) represent the largest family of E3 ubiquitin ligases that control most if not all cellular processes. In CUL3-based CRLs, the substrate specificity is conferred by the interaction with one of around 183 existing BTB proteins, implying a broad spectrum of possible ubiquitylation signals and possible direct ubiquitylation substrates. Indeed, CUL3-based E3-ligases can catalyze various proteolytic and non-proteolytic ubiquitin signals regulating many physiological and pathophysiological states. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10849521183003
Publisher Site
http://dx.doi.org/10.1016/j.semcdb.2018.12.007DOI Listing
December 2018
10 Reads

Decoding epigenetic cell signaling in neuronal differentiation.

Semin Cell Dev Biol 2019 Jan 24. Epub 2019 Jan 24.

Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil; Instituto Nanocell, Divinópolis, MG, Brazil. Electronic address:

Neurogenesis is the process by which new neurons are generated in the brain. Neural stem cells (NSCs) are differentiated into neurons, which are integrated into the neural network. Nowadays, pluripotent stem cells, multipotent stem cells, and induced pluripotent stem cells can be artificially differentiated into neurons utilizing several techniques. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.semcdb.2018.12.006DOI Listing
January 2019
2 Reads

When ubiquitin meets E-cadherin: Plasticity of the epithelial cellular barrier.

Semin Cell Dev Biol 2018 Dec 19. Epub 2018 Dec 19.

IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Via Adamello 16, Milan 20139, Italy; Dipartimento di oncologia ed emato-oncologia, Universita' degli Studi di Milano, Via Santa Sofia 9/1, Milan 20122, Italy. Electronic address:

Cellular plasticity is, by definition, the ability of cells to adapt to a dynamic micro-environment by changing their phenotype. E-cadherin is the key organizer of the epithelial cell barrier, and it is required at the cell surface to preserve epithelial tissue integrity and homeostasis, since it not only organizes the adherens junctions, but also transfers intracellular signals that provide cues to regulate cell survival, morphology and polarity. As such, de-regulation of E-cadherin has deleterious effects on cells and whole tissues. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.semcdb.2018.12.005DOI Listing
December 2018
2 Reads

The role of neurogenesis in neurorepair after ischemic stroke.

Semin Cell Dev Biol 2019 Jan 18. Epub 2019 Jan 18.

Departamento de Farmacologia, Instituto de Ciências Biológicas, Universidade Federal de Goiás, Goiânia, Brazil. Electronic address:

Stroke consists of an abrupt reduction of cerebral blood flow resulting in hypoxia that triggers an excitotoxicity, oxidative stress, and neuroinflammation. After the ischemic process, neural precursor cells present in the subventricular zone of the lateral ventricle and subgranular zone of the dentate gyrus proliferate and migrate towards the lesion, contributing to the brain repair. The neurogenesis is induced by signal transduction pathways, growth factors, attractive factors for neuroblasts, transcription factors, pro and anti-inflammatory mediators and specific neurotransmissions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.semcdb.2018.12.003DOI Listing
January 2019
10 Reads

Calcium signalling: A common target in neurological disorders and neurogenesis.

Semin Cell Dev Biol 2018 Dec 13. Epub 2018 Dec 13.

Department of Biochemistry, IQ, University of Sao Paulo, Sao Paulo, Brazil. Electronic address:

Calcium is an ubiquitous second messenger used by any living cell. The fine-tuning of intracellular free calcium concentration ([Ca]) homeostasis and signalling pathways is crucial for the maintenance of the healthy organism. Many alterations in the homeostasis can be compensated by robust mechanisms; however, cells that already present some debility in those mechanisms, or that are over stimulated cannot compensate the stress and die. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.semcdb.2018.12.002DOI Listing
December 2018
1 Read

Editorial.

Semin Cell Dev Biol 2018 Dec 19. Epub 2018 Dec 19.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.semcdb.2018.12.004DOI Listing
December 2018
1 Read

Purinergic signalling and brain development.

Semin Cell Dev Biol 2018 Dec 4. Epub 2018 Dec 4.

CNC - Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504, Coimbra, Portugal; Faculty of Medicine, University of Coimbra, Coimbra, 3004-504, Portugal.

ATP and adenosine are released from cells as a function of their metabolic activity, being important cell-to-cell communication signals. Both purines are also released from neurons in an activity-dependent manner, with several established roles to fine tune brain function in adults, as best heralded by the effects of caffeine, an antagonist of adenosine receptors. Purines are also dynamically released from early neurogenesis and different purine receptors are dynamically expressed throughout development. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.semcdb.2018.12.001DOI Listing
December 2018
1 Read

Signaling within the pineal gland: A parallelism with the central nervous system.

Semin Cell Dev Biol 2018 Nov 30. Epub 2018 Nov 30.

Institute of Histology and Embryology of Mendoza (IHEM), National University of Cuyo, National Scientific and Technical Research Council (CONICET), Mendoza, Argentina. Electronic address:

The pineal gland (PG) derives from the neural tube, like the rest of the central nervous system (CNS). The PG is specialized in synthesizing and secreting melatonin in a circadian fashion. The nocturnal elevation of melatonin is a highly conserved feature among species which proves its importance in nature. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.semcdb.2018.11.004DOI Listing
November 2018
3 Reads

MR1-dependent antigen presentation.

Semin Cell Dev Biol 2018 Dec;84:58-64

Pulmonary & Critical Care Medicine, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA; Portland VA Medical Center, 3710 SW US Veterans Hospital Road, Portland, OR 97239, USA; Molecular Microbiology and Immunology, Oregon Health & Science University, 3181 SW Sam Jackson Park Road. Portland, OR 97239, USA. Electronic address:

MR1 is a non-classical class I molecule that is highly conserved among mammals. Though discovered in 1995, only recently have MR1 ligands and antigens for MR1-restricted T cells been described. Unlike the traditional class I molecules HLA-A, -B, and -C, little MR1 is on the cell surface. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10849521163048
Publisher Site
http://dx.doi.org/10.1016/j.semcdb.2017.11.028DOI Listing
December 2018
6 Reads

The intersection of affinity and specificity in the development and optimization of T cell receptor based therapeutics.

Semin Cell Dev Biol 2018 Dec;84:30-41

Department of Chemistry and Biochemistry and the Harper Cancer Research Institute, University of Notre Dame, 251 Nieuwland Science Hall, Notre Dame, IN 46556 USA. Electronic address:

The role of the αβ T cell receptor (TCR) in identifying immunological targets and signaling appropriate responses provides for exciting translational opportunities. Yet TCRs mediate one of the most complex protein-protein interactions in biology, with intricate signaling and selection mechanisms adding additional layers of sophistication. In this review, we discuss how these complexities influence the development and optimization of TCR-based therapeutics, focusing on the intersection between structure, affinity, and specificity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.semcdb.2017.10.017DOI Listing
December 2018
1 Read

The use of proteomics to understand antiviral immunity.

Semin Cell Dev Biol 2018 Dec 8;84:22-29. Epub 2018 Oct 8.

Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia. Electronic address:

Viruses are intracellular pathogens that cause a vast array of diseases, which are often severe and typified by high morbidity and mortality rates. Viral infections continue to be a global health burden and effective vaccines and therapeutics are constantly sought to prevent and treat these infections. The development of such treatments generally relies on understanding the mechanisms that underpin efficient host antiviral immune responses. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10849521163045
Publisher Site
http://dx.doi.org/10.1016/j.semcdb.2017.12.002DOI Listing
December 2018
9 Reads

Seminars in cell and developmental biology.

Semin Cell Dev Biol 2018 Nov 22. Epub 2018 Nov 22.

Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Australia. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.semcdb.2018.11.003DOI Listing
November 2018
2 Reads

TRP channels in cardiac and intestinal fibrosis.

Semin Cell Dev Biol 2018 Nov 17. Epub 2018 Nov 17.

Department of Physiology, Fukuoka University School of medicine, Nanakuma 7-451, Jonan-ku, Fukuoka 814-0180, Japan.

It is now widely accepted that advanced fibrosis underlies many chronic inflammatory disorders and is the main cause of morbidity and mortality of the modern world. The pathogenic mechanism of advanced fibrosis involves diverse and intricate interplays between numerous extracellular and intracellular signaling molecules, among which the non-trivial roles of a stress-responsive Ca/Na-permeable cation channel superfamily, the transient receptor potential (TRP) protein, are receiving growing attention. Available evidence suggests that several TRP channels such as TRPC3, TRPC6, TRPV1, TRPV3, TRPV4, TRPA1, TRPM6 and TRPM7 may play central roles in the progression and/or prevention of fibroproliferative disorders in vital visceral organs such as lung, heart, liver, kidney, and bowel as well as brain, blood vessels and skin, and may contribute to both acute and chronic inflammatory processes involved therein. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10849521183004
Publisher Site
http://dx.doi.org/10.1016/j.semcdb.2018.11.002DOI Listing
November 2018
22 Reads

Calcium signalling and breast cancer.

Semin Cell Dev Biol 2018 Nov 16. Epub 2018 Nov 16.

The School of Pharmacy, The University of Queensland, Woolloongabba, QLD, 4102, Australia; Mater Research Institute, The University of Queensland, Translational Research Institute, Woolloongabba, QLD, 4102, Australia. Electronic address:

The past two decades have seen the identification of important roles for calcium signalling in many of the hallmarks of cancer. One of the cancer types that has been a particular focus of such studies is breast cancer. The breast is intrinsically linked to the calcium ion due to the importance of milk calcium in neonatal growth and development. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.semcdb.2018.11.001DOI Listing
November 2018
2 Reads

Like a hole in the head: Development, evolutionary implications and diseases of the cranial foramina.

Semin Cell Dev Biol 2018 Oct 30. Epub 2018 Oct 30.

Dept. Comparative Biomedical Sciences, Royal Veterinary College, Royal College St, London, NW1 0TU, United Kingdom.

Cranial foramina are holes in the skull through which nerves and blood vessels pass to reach both deep and superficial tissues. They are often overlooked in the literature; however they are complex structures that form within the developing cranial bones during embryogenesis and then remain open throughout life, despite the bone surrounding them undergoing constant remodelling. They are invaluable in assigning phylogeny in the fossil record and their size has been used, by some, to imply function of the nerve and/or blood vessel that they contained. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.semcdb.2018.08.011DOI Listing
October 2018
1 Read

Dissecting cellular mechanics: Implications for aging, cancer, and immunity.

Semin Cell Dev Biol 2018 Oct 30. Epub 2018 Oct 30.

Johns Hopkins Physical Sciences - Oncology Center, The Johns Hopkins University, Baltimore, MD 21218, USA; Department of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore, MD 21218, USA. Electronic address:

Cells are dynamic structures that must respond to complex physical and chemical signals from their surrounding environment. The cytoskeleton is a key mediator of a cell's response to the signals of both the extracellular matrix and other cells present in the local microenvironment and allows it to tune its own mechanical properties in response to these cues. A growing body of evidence suggests that altered cellular viscoelasticity is a strong indicator of disease state; including cancer, laminopathy (genetic disorders of the nuclear lamina), infection, and aging. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.semcdb.2018.10.008DOI Listing
October 2018
15 Reads

Impaired proteostasis in rare neurological diseases.

Semin Cell Dev Biol 2018 Nov 2. Epub 2018 Nov 2.

Department of Biochemistry and Molecular Biology, Faculty of Science and Technology, University of the Basque Country (UPV/EHU), 48940 Leioa, Spain; Ikerbasque, Basque Foundation for Science, 48013 Bilbao, Spain. Electronic address:

Rare diseases are classified as such when their prevalence is 1:2000 or lower, but even if each of them is so infrequent, altogether more than 300 million people in the world suffer one of the ∼7000 diseases considered as rare. Over 1200 of these disorders are known to affect the brain or other parts of our nervous system, and their symptoms can affect cognition, motor function and/or social interaction of the patients; we refer collectively to them as rare neurological disorders or RNDs. We have focused this review on RNDs known to have compromised protein homeostasis pathways. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.semcdb.2018.10.007DOI Listing
November 2018
13 Reads

Development of mesenteric tissues.

Semin Cell Dev Biol 2018 Oct 25. Epub 2018 Oct 25.

Department of Surgery, University Hospital Limerick, Limerick, Ireland; Graduate Entry Medical School, University of Limerick, Limerick, Ireland; Centre for Interventions in Infection, Inflammation and Immunity (4i), University of Limerick, Limerick, Ireland. Electronic address:

Mesothelial, neurovascular, lymphatic, adipose and mesenchymal tissues make up the mesentery. These tissues are pathobiologically important for numerous reasons. Collectively, they form a continuous, discrete and substantive organ. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.semcdb.2018.10.005DOI Listing
October 2018
2 Reads

Mesenteric organogenesis.

Semin Cell Dev Biol 2018 Oct 25. Epub 2018 Oct 25.

Graduate Entry Medical School, University of Limerick, Ireland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.semcdb.2018.10.006DOI Listing
October 2018
1 Read

Anatomy of the mesentery: Current understanding and mechanisms of attachment.

Semin Cell Dev Biol 2018 Oct 15. Epub 2018 Oct 15.

Department of Surgery, University Hospital Limerick, Limerick, Ireland; Graduate Entry Medical School, University of Limerick, Limerick, Ireland; Centre for Interventions in Infection, Inflammation and Immunity (4i), University of Limerick, Limerick, Ireland. Electronic address:

An understanding of the anatomy of the mesentery is necessary to undertake any appraisal of the literature on its development. The mesentery is the collection of tissues that maintain all abdominal digestive organs in position and connection with the rest of the body. Therefore, it is also necessary to detail the exact mechanisms that maintain the mesentery in position. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10849521183020
Publisher Site
http://dx.doi.org/10.1016/j.semcdb.2018.10.004DOI Listing
October 2018
2 Reads

Anatomy of the mesentery: Historical development and recent advances.

Semin Cell Dev Biol 2018 Oct 16. Epub 2018 Oct 16.

Department of Surgery, University Hospital Limerick, Limerick, Ireland; Graduate Entry Medical School, University of Limerick, Limerick, Ireland; Centre for Interventions in Infection, Inflammation and Immunity (4i), University of Limerick, Limerick, Ireland. Electronic address:

Recent appraisals of mesenteric anatomy clarify its structure and show a continuous and helical-shaped organ. This new model signifies a departure from the conventional model which described multiple, separate "mesenteries". Renaissance anatomists depicted the mesentery as a continuous structure. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.semcdb.2018.10.003DOI Listing
October 2018
1 Read

Fishing for collagen function: About development, regeneration and disease.

Semin Cell Dev Biol 2018 Oct 16. Epub 2018 Oct 16.

Université de Lyon, ENSL, CNRS, Institut de Génomique Fonctionnelle de Lyon, 46 allée d'Italie F-69364 Lyon, France. Electronic address:

Collagens are the most abundant vertebrate extracellular matrix proteins. They form a superfamily of 28 members that show a remarkable diversity in molecular and supramolecular organization, tissue distribution and function and mutations in collagen genes result in a wide range of inherited connective tissue diseases. In the recent years, unexpected and very diverse regulatory and mechanical collagen functions have been reported. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.semcdb.2018.10.002DOI Listing
October 2018
1 Read

Viscoelasticity of multicellular systems: From subcellular to supracellular levels.

Semin Cell Dev Biol 2018 Oct 10. Epub 2018 Oct 10.

University of Belgrade, Faculty of Technology and Metallurgy, Belgrade, Serbia. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10849521183024
Publisher Site
http://dx.doi.org/10.1016/j.semcdb.2018.10.001DOI Listing
October 2018
7 Reads

Tenascins in CNS lesions.

Semin Cell Dev Biol 2018 Oct 10. Epub 2018 Oct 10.

Department of Cell Morphology and Molecular Neurobiology, Faculty of Biology and Biotechnology, Ruhr-University Bochum, Universitaetsstrasse 150, 44780 Bochum, Germany. Electronic address:

The tenascin family of glycoproteins comprises four members in vertebrates, of which tenascin-C (Tnc) and tenascin-R (Tnr) are particularly important in the context of lesions in the central nervous system (CNS). Tnc is expressed in the developing CNS, before it is down-regulated and mainly restricted to the adult neural stem cell niches. It regulates numerous processes including differentiation, adhesion, migration and neurite outgrowth. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10849521173058
Publisher Site
http://dx.doi.org/10.1016/j.semcdb.2018.09.012DOI Listing
October 2018
6 Reads

The Mediator complex and the role of protein-protein interactions in the gene regulation machinery.

Authors:
Emma Sierecki

Semin Cell Dev Biol 2018 Oct 15. Epub 2018 Oct 15.

EMBL Australia Node in Single Molecule Science, and School of Medical Sciences, Faculty of Medecine, The University of New South Wales, Sydney, Australia. Electronic address:

At the core of gene regulation, a complex network of dynamic interactions between proteins, DNA and RNA has to be integrated in order to generate a binary biological output. Large protein complexes, called adaptors, transfer information from the transcription factors to the transcription machinery [1,2]. Here we focus on Mediator, one of the largest adaptor proteins in humans [3]. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10849521173039
Publisher Site
http://dx.doi.org/10.1016/j.semcdb.2018.08.006DOI Listing
October 2018
3 Reads

Ubiquitin-dependent protein degradation at the endoplasmic reticulum and nuclear envelope.

Semin Cell Dev Biol 2018 Oct 9. Epub 2018 Oct 9.

Department of Molecular Biophysics & Biochemistry, Yale University, New Haven, CT, 06520, USA; Department of Molecular, Cellular, & Developmental Biology, Yale University, New Haven, 06520, CT, USA. Electronic address:

Numerous nascent proteins undergo folding and maturation within the luminal and membrane compartments of the endoplasmic reticulum (ER). Despite the presence of various factors in the ER that promote protein folding, many proteins fail to properly fold and assemble and are subsequently degraded. Regulatory proteins in the ER also undergo degradation in a way that is responsive to stimuli or the changing needs of the cell. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10849521183006
Publisher Site
http://dx.doi.org/10.1016/j.semcdb.2018.09.013DOI Listing
October 2018
4 Reads

Perineuronal nets in brain physiology and disease.

Semin Cell Dev Biol 2018 Oct 9. Epub 2018 Oct 9.

Centre for Interdisciplinary Research in Biology (CIRB), Collège de France, CNRS UMR 7241, INSERM U1050, PSL University, Labex MemoLife, 75005 Paris, France. Electronic address:

Perineuronal nets (PNNs) in the brain are condensed glycosaminoglycan-rich extracellular matrix structures with heterogeneous composition yet specific organization. They typically assemble around a subset of fast-spiking interneurons that are implicated in learning and memory. Owing to their unique structural organization, PNNs have neuroprotective capacities but also participate in signal transduction and in controlling neuronal activity and plasticity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.semcdb.2018.09.011DOI Listing
October 2018
3 Reads

Viscoelasticity of single cells-from subcellular to cellular level.

Authors:
Erich Sackmann

Semin Cell Dev Biol 2018 Oct 3. Epub 2018 Oct 3.

Physics Department E22, Technical University Munich, James Franck Str. 1, D85747, Garching, Germany. Electronic address:

This review deals with insights into complex cellular structures and processes obtained by measuring viscoelastic impedances of the cell envelope and the cytoplasm by colloidal bead microrheometry. I first introduce a mechanical cell model that allows us to understand their unique ability of mechanical self-stabilization by actin microtubule crosstalk. In the second part, I show how cell movements can be driven by pulsatile or propagating solitary actin gelatin waves (SAGW) that are generated on nascent adhesion domains by logistically controlled membrane recruitment of functional proteins by electrostatic-hydrophobic forces. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10849521173056
Publisher Site
http://dx.doi.org/10.1016/j.semcdb.2018.09.010DOI Listing
October 2018
13 Reads

Cell cluster migration: Connecting experiments with physical models.

Semin Cell Dev Biol 2018 Sep 29. Epub 2018 Sep 29.

Department of Chemical and Biological Physics, Weizmann Institute, Rehovot, Israel. Electronic address:

In multi-cellular organisms, the migration of cohesive clusters of cells containing many individual cells is a common occurrence. Examples include the migration of cells during processes such as the development of the embryo, wound healing, immune response, and the spread of cancer. The migration process depends not only on the traction forces applied by the cluster on its surroundings, in order to move, but also on the viscoelastic properties of both the surrounding matrix and the migrating cellular cluster. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10849521183014
Publisher Site
http://dx.doi.org/10.1016/j.semcdb.2018.09.009DOI Listing
September 2018
3 Reads

Molecular regulation of ocular gland development.

Semin Cell Dev Biol 2018 Sep 25. Epub 2018 Sep 25.

Centre for Craniofacial and Regenerative Biology, King's College London, Floor 27, Guy's Tower, Guy's Hospital, London SE1 9RT, UK. Electronic address:

The tear film is produced by two ocular glands, the lacrimal glands, which produce the aqueous component of this film, and the meibomian glands, which secrete the lipidic component that is key to reduce evaporation of the watery film at the surface of the eye. Embryonic development of these exocrine glands has been mostly studied in mice, which also develop Harderian glands, a third type of ocular gland whose role is still not well understood. This review provides an update on the signalling pathways, transcription factors andextracellular matrix components that have been shown to play a role in ocular gland development. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10849521173051
Publisher Site
http://dx.doi.org/10.1016/j.semcdb.2018.07.023DOI Listing
September 2018
2 Reads

Information flow in the presence of cell mixing and signaling delays during embryonic development.

Semin Cell Dev Biol 2018 Oct 11. Epub 2018 Oct 11.

Graduate School of Natural Science and Technology, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan. Electronic address:

Embryonic morphogenesis is organized by an interplay between intercellular signaling and cell movements. Both intercellular signaling and cell movement involve multiple timescales. A key timescale for signaling is the time delay caused by preparation of signaling molecules and integration of received signals into cells' internal state. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.semcdb.2018.09.008DOI Listing
October 2018
4 Reads

Embryology, anatomy, physiology and pathophysiology of the peritoneum and the peritoneal vasculature.

Semin Cell Dev Biol 2018 Oct 8. Epub 2018 Oct 8.

Dept. of Gynecologic Oncology, Center for Gynecologic Oncology Amsterdam, The Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands. Electronic address:

The peritoneum is a large serous membrane with both epithelial and mesenchymal features, and is essential for maintaining an intra-abdominal homeostatic equilibrium. The peritoneum plays a central role in the pathogenesis of a number of disorders. Pathological processes affecting the peritoneum such as inflammation and carcinomatosis can have serious clinical consequences, but the pathophysiology of these conditions is poorly understood. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.semcdb.2018.09.007DOI Listing
October 2018
1 Read

Mesothelial-mesenchymal transitions in embryogenesis.

Semin Cell Dev Biol 2018 Sep 26. Epub 2018 Sep 26.

Department of Animal Biology, Faculty of Science, University of Málaga, 29071 Málaga (Spain) and Andalusian Center for Nanomedicine and Biotechnology (BIONAND), Malaga, Spain. Electronic address:

Most animals develop coelomic cavities lined by an epithelial cell layer called the mesothelium. Embryonic mesothelial cells have the ability to transform into mesenchymal cells which populate many developing organs contributing to their connective and vascular tissues, and also to organ-specific cell types. Furthermore, embryonic mesothelium and mesothelial-derived cells produce essential signals for visceral morphogenesis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.semcdb.2018.09.006DOI Listing
September 2018
1 Read

The role of ubiquitination in the regulation of primary cilia assembly and disassembly.

Semin Cell Dev Biol 2018 Sep 13. Epub 2018 Sep 13.

Institut de recherches cliniques de Montréal, Montreal, Quebec, H2W 1R7, Canada; Division of Experimental Medicine, McGill University, Montreal, Quebec, H4A 3J1, Canada; Department of Pathology and Cell Biology, Université de Montréal, Montreal, Quebec, H3C 3J7, Canada. Electronic address:

The primary cilium is a cellular antenna found on the surface of many eukaryotic cells, whose main role is to sense and transduce signals that regulate growth, development, and differentiation. Although once believed to be a vestigial organelle without important function, it has become clear that defects in primary cilium are responsible for a wide variety of genetic diseases affecting many organs and tissues, including the brain, eyes, heart, kidneys, liver, and pancreas. The primary cilium is mainly present in quiescent and differentiated cells, and controls must exist to ensure that this organelle is assembled or disassembled at the right time. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10849521183003
Publisher Site
http://dx.doi.org/10.1016/j.semcdb.2018.09.005DOI Listing
September 2018
11 Reads

Roles of ubiquitin in autophagy and cell death.

Semin Cell Dev Biol 2018 Sep 10. Epub 2018 Sep 10.

Institute of Molecular Biotechnology of Austrian Academy of Sciences (IMBA), Vienna Biocenter, Dr. Bohr-gasse 3, Vienna, Austria. Electronic address:

The balance between cell survival and cell death is often lost in human pathologies such as inflammation and cancer. Autophagy plays a critical role in cell survival: essential nutrients are generated by autophagy-dependent degradation and recycling of cellular garbage. On the other hand, cell death is induced by different programs, such as apoptosis, pyroptosis, and necroptosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.semcdb.2018.09.004DOI Listing
September 2018
1 Read

The contributions of mesoderm-derived cells in liver development.

Semin Cell Dev Biol 2018 Sep 10. Epub 2018 Sep 10.

Ministry of Education Key Laboratory of Cell Proliferation and Differentiation, College of Life Sciences, Peking-Tsinghua Center for Life Sciences, China. Electronic address:

The liver is an indispensable organ for metabolism and drug detoxification. The liver consists of endoderm-derived hepatobiliary lineages and various mesoderm-derived cells, and interacts with the surrounding tissues and organs through the ventral mesentery. Liver development, from hepatic specification to liver maturation, requires close interactions with mesoderm-derived cells, such as mesothelial cells, hepatic stellate cells, mesenchymal cells, liver sinusoidal endothelial cells and hematopoietic cells. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10849521173053
Publisher Site
http://dx.doi.org/10.1016/j.semcdb.2018.09.003DOI Listing
September 2018
15 Reads
6.260 Impact Factor

The mesentery as the epicenter for intestinal regeneration.

Semin Cell Dev Biol 2018 Sep 5. Epub 2018 Sep 5.

Biology Department, University of Puerto Rico, Puerto Rico. Electronic address:

The mesentery, a newly minted organ, plays various anatomical and physiological roles during animal development. In echinoderms, and particularly in members of the class Holothuroidea (sea cucumbers) the mesentery plays an additional unique role: it is crucial for the process of intestinal regeneration. In these organisms, a complete intestine can form from cells that originate in the mesentery. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.semcdb.2018.09.001DOI Listing
September 2018
1 Read