38 results match your criteria Seizures and Epilepsy Overview and Classification

  • Page 1 of 1

The new classification of seizures: an overview for the general physician.

J R Coll Physicians Edinb 2017 Dec;47(4):336-338

RM Bracewell, Walton Centre NHS Foundation Trust, Liverpool L9 7LJ, UK. Email:

The International League Against Epilepsy Classification of the Epilepsies, first presented in 1981, has been widely adopted across the globe. In 2017 it was revised to allow for more robust, specific, flexible and logical classification of seizures. A number of new seizure types are recognised. Read More

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http://dx.doi.org/10.4997/JRCPE.2017.406DOI Listing
December 2017
1 Read

[Psychiatry of the future: an overview of foreign scientists opinions of the position of psychiatry in the modern world].

Zh Nevrol Psikhiatr Im S S Korsakova 2017 ;117(7):107-111

Serbsky Federal Medical Research Center for Psychiatry and Narcology, Moscow, Russia.

First part of this review (Chapter 1) demonstrates an ambiguous attitude toward psychiatry among professionals and in society in recent decades. The articles of supporters and opponents of psychiatry are also quoted. The authors describe the dynamics of the reflection of psychopathology in the main widely accepted classifications and manuals. Read More

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http://dx.doi.org/10.17116/jnevro201711771107-111DOI Listing
February 2018
11 Reads

Comprehensive overview: efficacy, tolerability, and cost-effectiveness of clobazam in Lennox-Gastaut syndrome.

Ther Clin Risk Manag 2015 8;11:905-14. Epub 2015 Jun 8.

Department of Pharmacy Practice, Creighton University School of Pharmacy, Omaha, NE, USA ; Department of Neurology, Creighton University School of Medicine, Omaha, NE, USA.

Clobazam is the newest medication approved by the US Food and Drug Administration (FDA) for the treatment of Lennox-Gastaut syndrome (LGS) in patients at least 2 years of age, although the medication has been available in countries around the world to treat epilepsy and anxiety disorders for many years. Though classified as a benzodiazepine, the drug differs structurally from other drugs in the class as it possesses nitrogen atoms at the 1 and 5 positions within the heterocyclic ring rather than at the 1 and 4 positions. This difference and the classification of clobazam as a partial agonist are believed to be responsible for the decreased incidence of sedative effects compared to other benzodiazepines. Read More

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http://dx.doi.org/10.2147/TCRM.S55930DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467745PMC
June 2015
1 Read

Seizures and epilepsy: an overview for neuroscientists.

Cold Spring Harb Perspect Med 2015 Jun 1;5(6). Epub 2015 Jun 1.

Division of Neurology, Department of Pediatrics, Sainte-Justine Hospital, Universite Montreal, Montreal, Quebec H3T 1C5, Canada.

Epilepsy is one of the most common and disabling neurologic conditions, yet we have an incomplete understanding of the detailed pathophysiology and, thus, treatment rationale for much of epilepsy. This article reviews the clinical aspects of seizures and epilepsy with the goal of providing neuroscientists an introduction to aspects that might be amenable to scientific investigation. Seizures and epilepsy are defined, diagnostic methods are reviewed, various clinical syndromes are discussed, and aspects of differential diagnosis, treatment, and prognosis are considered to enable neuroscientists to formulate basic and translational research questions. Read More

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http://dx.doi.org/10.1101/cshperspect.a022426DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4448698PMC
June 2015
5 Reads

Syndromes at risk of status epilepticus in children: genetic and pathophysiological issues.

Epileptic Disord 2014 Oct;16 Spec No 1:S89-95

Department of Child Neurology, University of Giessen, Giessen, Germany.

Status epilepticus (SE) is a medical emergency with increased risk of morbidity and mortality in all age groups. Recent research has identified a variety of new genes implicated in disorders with severe epilepsies as a prominent feature. Autoimmune mechanisms have also been recently recognised as a cause of epilepsies with SE as a characteristic symptom. Read More

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http://dx.doi.org/10.1684/epd.2014.0688DOI Listing
October 2014
5 Reads

Seizure detection, seizure prediction, and closed-loop warning systems in epilepsy.

Epilepsy Behav 2014 Aug 29;37:291-307. Epub 2014 Aug 29.

Division of Epilepsy and Clinical Neurophysiology, Department of Neurology, Boston Children's Hospital, Boston, MA, USA. Electronic address:

Nearly one-third of patients with epilepsy continue to have seizures despite optimal medication management. Systems employed to detect seizures may have the potential to improve outcomes in these patients by allowing more tailored therapies and might, additionally, have a role in accident and SUDEP prevention. Automated seizure detection and prediction require algorithms which employ feature computation and subsequent classification. Read More

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http://dx.doi.org/10.1016/j.yebeh.2014.06.023DOI Listing
August 2014
27 Reads

[How do antiepileptic drugs work?].

Tidsskr Nor Laegeforen 2014 Jan;134(1):42-6

Background: There are currently around 25 antiepileptic drugs in use in Norway, of which 15 have entered the market in the last 20 years. All have somewhat different effect- and adverse effect profiles and mechanisms of action. Here we present a brief overview of current knowledge regarding the basic mechanisms of action of these drugs. Read More

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http://dx.doi.org/10.4045/tidsskr.13.0761DOI Listing
January 2014
8 Reads

Recent Research on Febrile Seizures: A Review.

J Neurol Neurophysiol 2013 Sep;4(165)

Department of Neurology, Virginia Commonwealth University, Richmond, USA.

Febrile seizures are common and mostly benign. They are the most common cause of seizures in children less than five years of age. There are two categories of febrile seizures, simple and complex. Read More

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http://dx.doi.org/10.4172/2155-9562.1000165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4220240PMC
September 2013
10 Reads

[Epilepsy-related psychoses].

Tidsskr Nor Laegeforen 2013 Jun;133(11):1205-9

Avdeling for kompleks epilepsi, Klinikk for kirurgi og nevrofag, Oslo universitetssykehus, Norway.

Background: Epilepsy-related psychoses lie in the border zone between neurology and psychiatry. The aim of this article is to give a brief overview of current knowledge of these psychoses, and to offer recommendations for their treatment.

Method: The article is based on a discretionary selection of articles found through a search in PubMed, as well as the authors' own experience with this patient group. Read More

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http://dx.doi.org/10.4045/tidsskr.12.1238DOI Listing
June 2013
2 Reads

[An overview of epilepsy: its history, classification, pathophysiology and management].

Authors:
Genjiro Hirose

Brain Nerve 2013 May;65(5):509-20

Asanogawa General Hospital Cranial Nerve Center, Ishikawa, Japan.

Epilepsy, a common chronic set of neurological disorders characterized by seizures, affects more than 50 million people worldwide. In fact, it is estimated that the annual incidence of new onset epilepsy in the general population is more than 80 per 100,000, occurring mostly in children and the elderly. Epilepsy is not a single specific disease, or even a single syndrome, but rather a broad category of symptom complexes arising from any number of disordered brain functions. Read More

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May 2013
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Epileptic encephalopathies: an overview.

Epilepsy Res Treat 2012 20;2012:403592. Epub 2012 Nov 20.

Department of Clinical Neurosciences, Prince Sultan Military Medical City, P.O. Box 7897, Riyadh 11159, Saudi Arabia.

Epileptic encephalopathies are an epileptic condition characterized by epileptiform abnormalities associated with progressive cerebral dysfunction. In the classification of the International League Against Epilepsy eight age-related epileptic encephalopathy syndromes are recognized. These syndromes include early myoclonic encephalopathy and Ohtahara syndrome in the neonatal period, West syndrome and Dravet syndrome in infancy, myoclonic status in nonprogressive encephalopathies, and Lennox-Gastaut syndrome, Landau-Kleffner syndrome, and epilepsy with continuous spike waves during slow wave sleep in childhood and adolescences. Read More

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http://dx.doi.org/10.1155/2012/403592DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3508533PMC
December 2012
2 Reads

Provoked and reflex seizures: surprising or common?

Epilepsia 2012 Sep;53 Suppl 4:105-13

University Hospital Utrecht, Utrecht, The Netherlands.

Most patients with epilepsy report that seizures are sometimes, or exclusively, provoked by general internal precipitants (such as stress, fatigue, fever, sleep, and menstrual cycle) and by external precipitants (such as excess alcohol, heat, bathing, eating, reading, and flashing lights). Some patients describe very exotic and precise triggers, like tooth brushing or listening to a particular melody. Nevertheless, the most commonly noticed seizure increasers by far are stress, lack of sleep, and fatigue. Read More

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http://dx.doi.org/10.1111/j.1528-1167.2012.03620.xDOI Listing
September 2012
2 Reads

Management of cortical dysplasia in epilepsy.

Authors:
S Fauser J Zentner

Adv Tech Stand Neurosurg 2012 ;38:137-63

Department of Neurosurgery, University of Freiburg, Freiburg, Germany.

Focal cortical dysplasias (FCD) are increasingly diagnosed as a cause of symptomatic focal epilepsy in paediatric and adult patients. Nowadays, focal cortical dysplasias are identified as the underlying pathology in up to 25% of patients with focal epilepsies. The histological appearance can vary from mild architectural disturbances to severe malformation containing atypical cellular elements like dysmorphic neurons and Balloon cells. Read More

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http://link.springer.com/10.1007/978-3-7091-0676-1_7
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http://dx.doi.org/10.1007/978-3-7091-0676-1_7DOI Listing
April 2016
5 Reads

A diagnostic algorithm for the evaluation of early onset genetic-metabolic epileptic encephalopathies.

Eur J Paediatr Neurol 2012 Mar 21;16(2):179-91. Epub 2011 Sep 21.

Division of Child Neurology, Department of Pediatrics, Child Neurology and Psychiatry, Sapienza University of Rome, via dei Sabelli 108, 00185 Roma, Italy.

Early onset epileptic encephalopathies represent a struggling challenge in neurological clinical practice, mostly in infants and very young children, partly due to an unclear and still debated cathegorization. In this scenario genetic and metabolic epileptic encephalopathies play a central role, with new entries still needing an arrangement. In this Paper we present a brief overview on genes, metabolic disorders and syndromes picturing the pathogenesis of genetic and metabolic epileptic encephalopathies with onset under one year of age. Read More

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http://dx.doi.org/10.1016/j.ejpn.2011.07.015DOI Listing
March 2012
9 Reads

Peroxisomal disorders with infantile seizures.

Brain Dev 2011 Oct 11;33(9):777-82. Epub 2011 Mar 11.

Department of Pediatrics and Medical Research, Far Eastern Memorial Hospital, Taipei, Taiwan.

Peroxisomes are organelles responsible for multiple metabolic pathways including the biosynthesis of plasmalogens and the oxidation of branched-chain as well as very-long-chain fatty acids (VLCFAs). Peroxisomal disorders (PDs) are heterogeneous groups of diseases and affect many organs with varying degrees of involvement. Even pathogenetically distinct PDs share some common symptoms. Read More

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http://dx.doi.org/10.1016/j.braindev.2011.02.004DOI Listing
October 2011
3 Reads

Seizure semiology: an overview of the 'inverse problem'.

Eur Neurol 2010 14;63(1):3-10. Epub 2009 Nov 14.

Service de Neurologie, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland. andrea.rossetti @ chuv.ch

In clinical practice, a classification of seizures based on clinical signs and symptoms leads to an improved understanding of epilepsy-related issues and therefore strongly contributes to a better patient care. The inverse problem involves inferring the anatomical brain localization of a seizure from the scalp surface EEG, a concept we apply here to correlate seizure origin with seizure semiology. The spheres of sensorium, motor features, consciousness changes and autonomic alterations during ictal and postictal manifestations are reviewed, including several subdivisions used to better categorize particular features. Read More

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http://dx.doi.org/10.1159/000258634DOI Listing
March 2010
4 Reads

Genes associated with idiopathic epilepsies: a current overview.

Neurol Res 2009 Mar;31(2):135-43

The First Affiliated Hospital, Chongqing Medical University, Chongqing, China.

Objective: This article aimed to review the latest genes associated with idiopathic focal and generalized epilepsies.

Methods: PubMed and Entrez Gene searches pertaining to this work was conducted using specific keyword search terms related to genes and various listed subtopics related to idiopathic epilepsy syndromes.

Results: Mutations in the cholinergic receptor, neuronal nicotinic, alpha2, alpha4 and beta2 subunit genes have been found in autosomal dominant nocturnal frontal lobe epilepsy. Read More

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http://www.tandfonline.com/doi/full/10.1179/174313209X393942
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http://dx.doi.org/10.1179/174313209X393942DOI Listing
March 2009
8 Reads

Drug treatment of epilepsy: options and limitations.

Authors:
Dieter Schmidt

Epilepsy Behav 2009 May 21;15(1):56-65. Epub 2009 Feb 21.

Epilepsy Research Group, Goethestrasse 5, D-14163 Berlin, Germany.

The modern antiepileptic drug (AED) era--spanning a period of more than 150 years from the first use of bromide in 1857 to 2008--has seen the introduction into clinical practice of a diverse group of effective and safe drugs. These AEDs have provided considerable benefits for those afflicted with epilepsy of all kinds. In as many as 60-70% of newly treated patients, current AEDs lead to satisfactory control of seizures and a favorable risk-benefit balance for the great majority of patients, albeit with considerable differences in response depending on the type of seizure and epilepsy syndrome and rare serious adverse events. Read More

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https://www.amherst.edu/media/view/303015/original/Epilepsy_
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http://linkinghub.elsevier.com/retrieve/pii/S152550500900089
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http://dx.doi.org/10.1016/j.yebeh.2009.02.030DOI Listing
May 2009
1 Read

Pediatric sleep and epilepsy.

Curr Neurol Neurosci Rep 2007 Jul;7(4):342-7

New York Sleep Institute, 724 Second Avenue, New York, NY 10016, USA.

Sleep disorders are common in childhood. The prevalence of childhood sleep disorders is higher in chronic neurologic disorders, specifically epilepsy. Sleep needs, requirements, and structure are different in children compared with adults. Read More

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July 2007
3 Reads

Clinical review of pediatric epilepsy.

Authors:
Mohammed M Jan

Neurosciences (Riyadh) 2005 Oct;10(4):255-64

Department of Pediatrics (Neurology), King Abdul-Aziz University Hospital, PO Box 80215, Jeddah 21589, Kingdom of Saudi Arabia. Tel. +966 (2) 6401000 Ext. 20208. Fax. +966 (2) 6403975. E-mail:

Seizure disorders are very common and represent the most common cause of referrals to pediatric neurology. Epilepsy, defined as recurrent unprovoked seizures, is also common with a frequency of 4-8 cases per 1000 children. In Saudi Arabia, inherited neurological disorders, including epilepsy and genetic epilepsy syndromes, are more common because of the high rate of consanguinity. Read More

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October 2005
3 Reads

The putative neuroprotective role of neuropeptide Y in the central nervous system.

Curr Drug Targets CNS Neurol Disord 2005 Aug;4(4):331-47

Center for Neuroscience and Cell Biology, Institute of Biochemistry, Faculty of Medicine, University of Coimbra, Rua Larga, 3004-504 Coimbra, Portugal.

Neuropeptide Y (NPY) is one of the most abundant and widely distributed neuropeptides in the mammalian central nervous system (CNS). An overview of the distribution of the G-protein coupled NPY receptor family (Y(1), Y(2), Y(4), Y(5) receptors) in the brain is described. The coexistence of NPY with other neurotransmitters and its wide distribution in several brain areas predict the high importance of NPY as a neuromodulator. Read More

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August 2005
2 Reads

Familial cortical myoclonic tremor with epilepsy: a single syndromic classification for a group of pedigrees bearing common features.

Mov Disord 2005 Jun;20(6):665-73

Departments of Neurology and Clinical Neurophysiology, Academic Medical Center, 1100 DD Amsterdam, The Netherlands.

Fifty Japanese and European families with cortical myoclonic tremor and epilepsy have been reported under various names. Unfamiliarity with the syndrome often leads to an initial misdiagnosis of essential tremor or progressive myoclonus epilepsy. A detailed overview of the literature is lacking and is the scope of this study. Read More

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http://doi.wiley.com/10.1002/mds.20413
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http://dx.doi.org/10.1002/mds.20413DOI Listing
June 2005
4 Reads

Efficacy of zonisamide: our experience.

Seizure 2004 Dec;13 Suppl 1:S41-8; discussion S49

Department of Neuropsychiatry, Saitama Medical School, Morohonngo 38, Moroyama-machi Iruma-gun, Saitama 350 0495, Japan.

The current overview of zonisamide use and effectiveness is based on both a long-term prospective postmarketing survey and current zonisamide use at the Saitama Medical College, Department of Neuropsychiatry. Survey data, which were collected from individual physicians and 23 survey groups throughout Japan, assessed the effectiveness of zonisamide in 1631 patients. Zonisamide was highly effective for treating partial seizures, with 70% of patients reporting improvement. Read More

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http://linkinghub.elsevier.com/retrieve/pii/S105913110400083
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http://dx.doi.org/10.1016/j.seizure.2004.04.021DOI Listing
December 2004
2 Reads

Overview: idiopathic generalized epilepsies.

Epilepsia 2003 ;44 Suppl 2:2-6

Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06520, U.S.A.

The idiopathic generalized epilepsies (IGEs) are an underemphasized topic. Two reasons for this relative lack of attention are that these epilepsies tend to be more easily controlled than the symptomatic partial and generalized epilepsies, and they are not as common. Because IGE usually arises in childhood or adolescence, these epilepsies may be thought of as a pediatric problem. Read More

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July 2003
2 Reads

Recent developments in treatment of status epilepticus: a review.

Epileptic Disord 2002 Oct;4 Suppl 2:S41-51

Interdiciplinary Epilepsy Center Marburg-Dept of Neurology, Philipps-University Marburg, Germany.

Considering that status epilepticus (SE) is a medical emergency associated with significant morbidity and mortality, there are surprisingly few evidence-based data to guide management decisions. The purpose of this review is to give an overview of the incidence and classification of SE and to summarise the recent developments in the treatment of generalized tonic clonic status epilepticus (GTCSE). These consist in two prospective randomised studies indicating that SE should be treated as soon as possible, even out-of hospital, by intravenous (IV) benzodiazepine. Read More

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October 2002
2 Reads

Ca2+ channels and epilepsy.

Authors:
Owen T Jones

Eur J Pharmacol 2002 Jul;447(2-3):211-25

Division of Neuroscience, School of Biological Sciences, University of Manchester, 1.136 Stopford Building, Oxford Road, Manchester, M13 9PT, UK.

The epilepsies encompass diverse seizure disorders afflicting as many as 50 million people worldwide. Many forms of epilepsy are intractable to current therapies and there is a pressing need to develop agents and strategies to not only suppress seizures, but also cure epilepsy. Recent insights from molecular genetics and pharmacology now point to an important role for voltage-dependent calcium channels in epilepsy. Read More

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July 2002
4 Reads

[Psychiatric and psychotherapeutic aspects in epileptology].

Authors:
M Schmutz A Toygar

Ther Umsch 2001 Nov;58(11):668-70

Abteilung Psychotherapie/Psychiatrie, Schweizerisches Epilepsie-Zentrum Zürich.

Many patients with epilepsy suffer also from coexisting psychological problems. The simultaneous treatment of the epileptic and the psychiatric disorder is necessary for a sufficient anticonvulsant management. Among those psychiatric disorders depressions, psychosis and psychogenic non-epileptic attacks are the most common. Read More

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http://dx.doi.org/10.1024/0040-5930.58.11.668DOI Listing
November 2001
2 Reads

The star systems: overview and use in determining antiepileptic drug choice.

Authors:
M J Brodie P Kwan

CNS Drugs 2001 Jan;15(1):1-12; discussion 13-5

University Department of Medicine and Therapeutics, Western Infirmary, Glasgow, Scotland.

An explosion in antiepileptic drug (AED) therapy began in the 1990s with the licensing of 9 new chemical entities and more to come. Important differences between AEDs may not be detected by regulatory trials, which are designed to satisfy licensing requirements and often diverge considerably from everyday clinical practice. The Star Systems have been developed as evidence-based yet pragmatic and flexible models for comparing AEDs. Read More

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http://dx.doi.org/10.2165/00023210-200115010-00001DOI Listing
January 2001
4 Reads

Epileptic seizures and syndromes.

Authors:
S R Benbadis

Neurol Clin 2001 May;19(2):251-70

Departments of Neurology and Neurosurgery, Comprehensive Epilepsy Program, University of South Florida College of Medicine, Tampa, Florida, USA.

This article describes the main characteristics of the different types of seizures and their classifications. The main types of epilepsies are reviewed, including their main, clinical, and EEG features and an overview of their treatment. Read More

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May 2001
2 Reads

Pathophysiology of epilepsy.

Acta Neurol Belg 2000 Dec;100(4):201-13

Department of Neurology, A.Z. Middelheim, Antwerp, Belgium.

This work reviews the current knowledge on epileptogenesis and pathophysiology of epilepsy. Recently, gene defects underlying four monogenic epilepsies (generalized epilepsy with febrile seizures, autosomal dominant nocturnal frontal lobe epilepsy, benign familial neonatal convulsions and episodic ataxia type 1 with partial seizures) have been identified, shedding new light on the pathophysiology of epilepsy as these diseases are caused by ion channel mutations. Although epileptic syndromes differ pathophysiologically, common ictogenesis-related characteristics as increased neuronal excitability and synchronicity are shared as well as mechanisms involved in interictal-ictal transition. Read More

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December 2000
13 Reads

Overview of childhood epilepsy and epileptic syndromes and advances in therapy.

Curr Pharm Des 2000 May;6(8):879-900

Virginia Commonwealth University/Medical College of Virginia, Division of Child Neurology, Richmond 23298-0211, USA.

Seizures have a variety of etiologies and manifestations. Descriptions of various epiletic seizures as well as electroencephalographic findings have led to a unifying international classification of epileptic seizures and epilepsy syndromes. The development of this classification system and the emergence of several new antiepiletic drugs have led to progress in the refractory pediatric patient particularly disorders which are traditionally difficult to treat such as infantile spasms and the Lennox-Gastaut Syndrome. Read More

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May 2000
2 Reads

Rapid-cycling bipolar disorder. An overview of research and clinical experience.

Psychiatr Clin North Am 1999 Sep;22(3):585-607

VA Puget Sound Health Care Services, Tacoma, Washington, USA.

Although many studies of RCBD have been reported over the last 2 decades, knowledge remains limited. Higher incidence in women is the sole clearly replicated finding in most studies. This finding might be mediated by cyclothymia, a temperament that is of higher prevalence in women and that might be considered as a normal variant of RC. Read More

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September 1999
1 Read

SUDEP: overview of definitions and review of incidence data.

Seizure 1999 Sep;8(6):347-52

The University of Texas Health Science Center Houston, School of Public Health, 1200 Herman Pressler, RAS-343, Houston, TX 77030, USA.

The classification, occurrence, and predictors of sudden unexpected and unexplained death in individuals with epilepsy (SUDEP) have received considerable attention over the last few years. Specific criteria for the classification of definite, probable, possible, and not SUDEP implemented in United States epidemiologic studies are presented. The incidence of SUDEP in different epilepsy populations is presented. Read More

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http://linkinghub.elsevier.com/retrieve/pii/S105913119990306
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http://dx.doi.org/10.1053/seiz.1999.0306DOI Listing
September 1999
5 Reads

Classifications and epidemiologic considerations of epileptic seizures and epilepsy.

Authors:
E L So

Neuroimaging Clin N Am 1995 Nov;5(4):513-26

Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.

The manifestations of epileptic disorders are widely known to be extremely protean. Classifying the disorders is a way of achieving a common understanding of the terminology used in identifying seizure disorders in the clinical or research settings. Two International Classifications have been developed, namely the International Classification of Epileptic Seizures and the International Classification of Epilepsy and Epileptic Syndromes. Read More

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November 1995
2 Reads

Overview of seizures.

Authors:
J Engel S Starkman

Emerg Med Clin North Am 1994 Nov;12(4):895-923

Department of Neurology, UCLA School of Medicine.

Epilepsy is a chronic disorder characterized by recurrent unprovoked epileptic seizures. Not all epileptic seizures indicate the existence of an epileptic disorder; many represent a natural response of the normal brain to transient noxious insults that are not likely to be repeated (reactive seizures). Not only is it important to distinguish conditions associated with these relatively benign epileptic events from epilepsy, but also it is important to recognize the many types of epileptic seizures and many types of epilepsy, reflecting different underlying anatomic and pathophysiologic substrates, which determine therapy and prognosis. Read More

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November 1994
2 Reads

Classification of epileptic seizures and the epilepsies: an overview.

Epilepsy Res Suppl 1992 ;6:3-11

Department of Neurology, School of Medicine, University of Virginia, Charlottesville 22908.

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December 1992
4 Reads

Feasibility of subclassification of temporal lobe epilepsy (1989): an etiological overview.

Jpn J Psychiatry Neurol 1990 Jun;44(2):417-9

National Epilepsy Center, Shizuoka Higashi Hospital.

Temporal lobe epilepsy with amygdalohippocampal seizures may have episodes of severe convulsions in childhood more frequently and the onset age is significantly lower compared to epilepsy with lateral temporal seizures. To the contrary, tumorous lesions are found more frequently in epilepsy with lateral temporal seizures. In view of the presumed known etiologies in relation to the localization of epileptogenic foci, the Classification of Epileptic Syndrome (1989), subdividing temporal lobe epilepsies into 2 groups, was found to be useful. Read More

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June 1990
2 Reads

An overview of pediatric seizure disorders and epileptic syndromes.

Authors:
B R Tharp

Epilepsia 1987 ;28 Suppl 1:S36-45

Seizures are common in infants and children and must be differentiated from a wide variety of other neurological and nonneurological disorders which include episodic disturbances of behavior. If the diagnosis is clear, then one must decide if the seizure is an isolated event and unlikely to recur (as are many afebrile generalized convulsive seizures in early childhood), a symptom of underlying cerebral pathology, or part of an epileptic syndrome. The latter may be a potentially lethal neurodegenerative disease or a benign epilepsy with excellent outcome. Read More

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October 1987
2 Reads
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