1,032 results match your criteria Seizures Simple Partial


Scott test associated with multivariate image analysis: A more selective alternative for cocaine research in forensic laboratories.

Forensic Sci Int 2022 Jun 21;335:111277. Epub 2022 Mar 21.

Instituto de Química, Universidade Federal de Goiás, 74690-900 Goiânia, GO, Brazil. Electronic address:

Scott test is a simple, rapid, and low-cost preliminary test used extensively to suggest the presence of cocaine in drug seizures due to the development of a blue color. However, the presence of cutting agents can compromise the test result and may suggest the presence of cocaine when the drug is absent. This study evaluated the frequency of these results and the spectral behavior and color development of false positive substances. Read More

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Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data.

Cochrane Database Syst Rev 2022 04 1;4:CD011412. Epub 2022 Apr 1.

Department of Health Data Science, University of Liverpool, Liverpool, UK.

Background: This is an updated version of the original Cochrane Review published in 2017. Epilepsy is a common neurological condition with a worldwide prevalence of around 1%. Approximately 60% to 70% of people with epilepsy will achieve a longer-term remission from seizures, and most achieve that remission shortly after starting antiepileptic drug treatment. Read More

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Serum Levels of Growth-Associated Protein-43 and Neurotrophin-3 in Childhood Epilepsy and Their Relation to Zinc Levels.

Biol Trace Elem Res 2022 Mar 29. Epub 2022 Mar 29.

Department of Pediatrics, Faculty of Medicine, South Valley University, Qena, Egypt.

Background: Epilepsy is one of the most common neurological disorders, and it places a significant economic strain on the healthcare system around the world. Although the exact mechanism of epilepsy has yet to be illustrated, various pathogenic cascades involving neurotransmitters and trace elements have been reported. We aimed to investigate the serum levels of growth-associated protein-43 (GAP-43) and neurotrophin-3 (NT-3) among cohort of Egyptian children with epilepsy and correlate these biomarkers with their zinc levels. Read More

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Epilepsia partialis continua associated with ketotic hyperglycemia and tuberculous meningoencephalitis: A case report.

Clin Case Rep 2022 Feb 15;10(2):e05460. Epub 2022 Feb 15.

Neurology Ward Department of Internal Medicine Hôpital Provincial Général de Référence de Bukavu (HPGRB) Bukavu Democratic Republic of the Congo.

We report the case of an 18-year-old girl who presented with several episodes of simple partial motor seizures compatible with the diagnosis of epilepsia partialis continua. In addition to ketotic hyperglycemia, tuberculous meningoencephalitis was diagnosed based on clinical, biological, and brain imaging findings. The seizures ceased after normalization of glycemia. Read More

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February 2022

Seizure Type Classification Using EEG Based on Gramian Angular Field Transformation and Deep Learning.

Annu Int Conf IEEE Eng Med Biol Soc 2021 11;2021:3340-3343

classification of seizure types plays a crucial role in diagnosis and prognosis of epileptic patients which has not been addressed properly, while most of the works are surrounded by seizure detection only. However, in recent times, few works have been attempted on the classification of seizure types using deep learning (DL). In this work, a novel approach based on DL has been proposed to classify four types of seizures - complex partial seizure, generalized non-specific seizure, simple partial seizure, tonic-clonic seizure, and seizure-free. Read More

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November 2021

Neoadjuvant fractionated stereotactic radiotherapy followed by piecemeal resection of brain metastasis: a case series of 20 patients.

Int J Clin Oncol 2022 Mar 18;27(3):481-487. Epub 2021 Nov 18.

Division of Neurosurgery, Shizuoka Cancer Center, 1007, Shimo-nagakubo, Naga-izumi, Shizuoka, 411-8777, Japan.

Background: The safety and effectiveness of neoadjuvant fractionated stereotactic radiotherapy (FSRT) before piecemeal resection of brain metastasis (BM) remains unknown.

Methods: We retrospectively reviewed 20 consecutive patients with BM who underwent neoadjuvant FSRT followed by piecemeal resection between July 2019 and March 2021. The prescribed dose regimens were as follows: 30 Gy (n = 11) or 35 Gy (n = 9) in five fractions. Read More

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Cardiac Sodium Channel Blockade Due to Antiepileptic Drug Combination.

Eur J Case Rep Intern Med 2021 4;8(10):002839. Epub 2021 Oct 4.

Department of Cardiology, Chest Diseases Hospital, Kuwait.

Drugs that inhibit voltage-dependent sodium channels are commonly used to treat epilepsy. Old and novel antiepileptic drugs are used either as monotherapy or in combination to control epilepsy. For a long time, carbamazepine has been used as the first choice for the treatment of simple and complex partial seizures. Read More

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October 2021

[Observation of efficacy and safety of stereotactic-EEG-guided three-dimensional radiofrequency thermocoagulation for the treatment of drug-resistant insular epilepsy].

Zhonghua Yi Xue Za Zhi 2021 Nov;101(41):3386-3392

Department of Neurosurgery, Xuanwu Hospital, Clinical Research Center for Epilepsy, Capital Medical University, Beijing 100053, China.

To investigate the safety and efficacy of stereotactic-EEG (SEEG)-guided radiofrequency thermocoagulation (RF-TC) with three-dimensional lesioning in the treatment of drug-resistant insular epilepsy. Seven patients with drug-resistant insular epilepsy who underwent SEEG-guided RF-TC with three-dimensional ablation at the Department of Neurosurgery of Xuanwu Hospital, Capital Medical University from February 2017 to June 2019 were retrospectively enrolled. Presurgical evaluation including semiology, EEG and imaging results suggested that the epileptogenic zone was located in the insular lobe. Read More

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November 2021

The protective effects of 1,3-butanediol acetoacetate diester on decompression sickness in rats.

J Appl Physiol (1985) 2021 08 24;131(2):435-441. Epub 2021 Jun 24.

Department of Diving and Hyperbaric Medicine, Naval Special Medicine Center, Naval Medical University, Shanghai, China.

Inert gas bubbles are widely accepted as the causative factor of decompression sickness (DCS), resulting in gas embolism and systemic inflammatory responses. The anticonvulsive ketone ester 1,3-butanediol acetoacetate diester (BD-AcAc) was reported to have the characteristics of increasing blood oxygen partial pressure (ppO) and anti-inflammation and was thought to have the potential to reduce bubble formation and alleviate the pathological process of DCS. This study aims to investigate the potential protection of BD-AcAc against DCS in a rat model. Read More

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Adult occipital lobe epilepsy: 12-years on.

J Neurol 2021 Oct 26;268(10):3926-3934. Epub 2021 Apr 26.

Western General Hospital, NHS Lothian, Edinburgh, EH4 2XU, UK.

Objective: Occipital lobe epilepsies (OLE) comprise 5-10% of focal epilepsies in surgical and paediatric series; with little data from adult medical cohorts. This longitudinal study examined OLE patients, to characterise prevalence, semiology, co-morbidity and prognosis in a neurology outpatient setting.

Methods: 24 adult OLE patients identified over 12 months from 1548 patients in a neurologist's service were followed over 12 years. Read More

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October 2021

Health-related quality of life in pediatric patients with partial onset seizures or primary generalized tonic-clonic seizures receiving adjunctive perampanel.

Epilepsy Behav 2021 05 8;118:107938. Epub 2021 Apr 8.

Eisai Inc., Woodcliff Lake, NJ, USA.

Rationale: Study 311 (E2007-G000-311; NCT02849626) was a Phase 3, multicenter, open-label single-arm study of adjunctive perampanel oral suspension in pediatric patients (aged 4 to <12 years) with partial-onset seizures (POS) (with/without secondarily generalized tonic-clonic seizures [SGTCS]) or primary generalized tonic-clonic seizures (PGTCS). Health-related quality of life (HRQoL) was an exploratory endpoint initially analyzed through simple descriptive summaries. The aim of this post hoc analysis was to provide a more thorough assessment of HRQoL. Read More

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The effect of a seminar on medical students' information acquisition of and attitudes toward epilepsy.

Epilepsy Behav 2021 03 21;116:107720. Epub 2021 Jan 21.

Istanbul University, Istanbul Medical Faculty, Department of Neurology, Istanbul, Turkey; Istanbul University Epilepsy Research Center, Istanbul, Turkey.

Aim: The aim of the present study was to investigate the effect of a brief seminar focusing on medical and social aspects of epilepsy on information acquisition of and attitudes toward epilepsy among medical school students.

Method: The sample of this pretest-posttest study consisted of 57 fifth-grade medical students. The students participated in a one-hour seminar including medical and social aspects of epilepsy. Read More

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F-FDG PET Imaging Predicts the Epileptogenic Zone Prospectively in Recurrent Cryptogenic Meningoencephalitis with Subsequent Simple Partial Visual Seizures.

Authors:
Mehdi Djekidel

J Nucl Med Technol 2021 Mar 20;49(1):92-94. Epub 2020 Nov 20.

Nuclear Medicine and Molecular Imaging, Sidra Medicine, Doha, Qatar

F-FDG PET scans have proven to be useful in the diagnosis and management of encephalitis patients. F-FDG PET scans are also the standard of care in the evaluation of epilepsy patients before surgery. Encephalitis patients who later develop epilepsy may have useful imaging findings at the time of diagnosis. Read More

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Case 284: Posterior Quadrantic Dysplasia.

Radiology 2020 12;297(3):733-737

From the Department of Diagnostic Radiology, SUNY Upstate Medical University, 750 E Adams St, Syracuse, NY 13210-2306.

History A 36-year-old left-handed woman with a history of developmental delay and medical refractory seizures since birth most recently presented with continuous simple partial seizures and occasional breakthrough complex partial seizures with postictal migraines. These were described as the patient "becoming pale with sinking to the floor and staring for approximately 1 minute with confusion thereafter." The patient had years of reported seizure freedom until 2010 when she was evaluated for intractable headaches, and electroencephalography revealed her focal subclinical status. Read More

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December 2020

COVID-19 containment and its unrestrained impact on epilepsy management in resource-limited areas of Pakistan.

Epilepsy Behav 2020 11 25;112:107476. Epub 2020 Sep 25.

Cell and Molecular Biology Laboratory, Department of Zoology, University of the Punjab, Lahore 54590, Pakistan; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China; University of Chinese Academy of Sciences, Beijing 100049, China.

The current pandemic of coronavirus disease 2019 (COVID-19) that led to an unprecedented crisis with significant health, social, and economic repercussions presented more serious concerns for those living with some chronic conditions such as epilepsy. This study was aimed to find out impact of the COVID-19 pandemic on management of epilepsy. A cross-sectional study was conducted through telephone interviews, targeting 213 caregivers of pediatric patients with epilepsy, belonging to underserved areas of Faisalabad, Punjab, Pakistan. Read More

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November 2020

Seizures with paroxysmal arousals in sleep-related hypermotor epilepsy (SHE): Dissecting epilepsy from NREM parasomnias.

Epilepsia 2020 10 19;61(10):2194-2202. Epub 2020 Sep 19.

Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.

Objective: Sleep-related hypermotor epilepsy (SHE) is a focal epilepsy characterized by seizures occurring mostly during sleep, ranging from brief seizures with paroxysmal arousals (SPAs) to hyperkinetic seizures and ambulatory behaviors. SPAs are brief and stereotypic seizures representing the beginning of a major seizure. Distinguishing SPAs from disorders of arousal (DOAs) and their briefest episodes called simple arousal movements (SAMs) is difficult. Read More

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October 2020

The Protective Effect of Breastfeeding on Febrile Seizures: A Case-Control Study.

Breastfeed Med 2020 11 3;15(11):709-714. Epub 2020 Sep 3.

Department of Pediatrics, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.

Our study was performed to analyze the interrelationship between breastfeeding for the first 6 months of life and the incidence of febrile seizures (FS). A case-control study was conducted in Renmin Hospital of Wuhan University. Three hundred thirty-six patients diagnosed with FS were enrolled as the case group, and 336 febrile children with matched age and gender were enrolled as the control group. Read More

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November 2020

The Unease When Using Anesthetics for Treatment-Refractory Status Epilepticus: Still Far Too Many Questions.

J Clin Neurophysiol 2020 Sep;37(5):399-405

Department of Intensive Care Medicine, University Hospital Basel, Basel, Switzerland.

Status epilepticus (SE), treatment-refractory status epilepticus (RSE), and super-treatment-refractory status epilepticus (SRSE) are associated with increased morbidity, mortality, and high socioeconomic burden and pose significant treatment challenges for intensivists and neurologists. To optimize and streamline emergency treatment, current practice guidelines recommend the use of continuously delivered intravenous anesthetic drugs such as midazolam, propofol, or barbiturates as the third-line therapy after first-line and second-line treatments have failed. Although the rationale for these third-line drugs seems intuitive at first glance, there is a clear paucity of evidence-based data on risks, benefits, and even on the choice of a third-line agent. Read More

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September 2020

The FDP/FIB Ratio and Blood FDP Level May Be Related to Seizures After Fever in Young Children.

Front Pediatr 2020 31;8:439. Epub 2020 Jul 31.

Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, China.

To evaluate the relationship of the blood fibrinogen (FIB) degradation product (FDP) level and FDP/FIB ratio with seizure in young children with fever. A total of 35 children with simple febrile seizures and 80 children with fever but no seizure were selected. First, the differences in white blood cell (WBC), platelets (PLT), prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT), FIB, FDP, FDP/FIB ratio, and C-reactive protein (CRP) between 35 children with simple febrile seizures and 40 randomly selected children with fever but no seizure were retrospectively analyzed. Read More

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Non-Gaussianity Detection of EEG Signals Based on a Multivariate Scale Mixture Model for Diagnosis of Epileptic Seizures.

IEEE Trans Biomed Eng 2021 02 20;68(2):515-525. Epub 2021 Jan 20.

Objective: The detection of epileptic seizures from scalp electroencephalogram (EEG) signals can facilitate early diagnosis and treatment. Previous studies suggested that the Gaussianity of EEG distributions changes depending on the presence or absence of seizures; however, no general EEG signal models can explain such changes in distributions within a unified scheme.

Methods: This article describes the formulation of a stochastic EEG model based on a multivariate scale mixture distribution that can represent changes in non-Gaussianity caused by stochastic fluctuations in EEG. Read More

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February 2021

Case 284.

Radiology 2020 08;296(2):460-462

From the Department of Diagnostic Radiology, SUNY Upstate Medical University, 750 E Adams St, Syracuse, NY 13210-2306.

History A 36-year-old left-handed woman with a history of developmental delay and medical refractory seizures since birth most recently presented with continuous simple partial seizures and occasional breakthrough complex partial seizures with postictal migraines. These were described as the patient "becoming pale with sinking to the floor and staring for approximately 1 minute with confusion thereafter." The patient had years of reported seizure freedom until 2010 when she was evaluated for intractable headaches, and electroencephalography revealed her focal subclinical status. Read More

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Surgically Treated Epilepsy due to Developmental Venous Anomaly of the Brain: Case Report and Review of the Literature.

Authors:
Kamran Aghayev

World Neurosurg 2020 09 12;141:119-122. Epub 2020 Jun 12.

Department of Neurosurgery, Biruni University, Istanbul, Turkey. Electronic address:

Background: A congenital malformation of the brain vessels, developmental venous anomaly (DVA) is considered a benign lesion, requiring no intervention unless symptomatic. Epilepsy is a well-known clinical manifestation of DVA. Successful surgery for DVA-associated epilepsy with has been sporadically reported in the literature; however, in all published cases, the anomaly was left intact along with the accompanying lesion. Read More

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September 2020

Which seizure elements do patients memorize? A comparison of history and seizure documentation.

Epilepsia 2020 07 9;61(7):1365-1375. Epub 2020 Jun 9.

Epilepsy Center, University Medical Center, University of Freiburg, Freiburg, Germany.

Objective: People with epilepsy (PWE) are frequently unable to recall the core manifestation of their disease, epileptic seizures. This means that seizure frequency is often underestimated by practitioners and that seizure classification based on reports of patients or their relatives is difficult because seizure semiology remains unclear. The purpose of this study, therefore, was to prospectively explore patients' memory regarding seizure elements and to assess the role of seizure types. Read More

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Mechanical Thrombectomy for Cerebral Venous Sinus Thrombosis: A Case Series and Technical Note.

World Neurosurg 2020 08 8;140:148-161. Epub 2020 May 8.

Division of Neuroradiology, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada; Division of Neurosurgery, Department of Surgery, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada.

Background: Cerebral venous sinus thrombosis is a rare cause of acute stroke. It may lead to hemorrhagic venous infarctions, brain swelling, or raised intracranial pressure and can be associated with significant mortality and morbidity. Low-molecular-weight heparin is the mainstay of treatment. Read More

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Seizure pathways change on circadian and slower timescales in individual patients with focal epilepsy.

Proc Natl Acad Sci U S A 2020 05 4;117(20):11048-11058. Epub 2020 May 4.

Interdisciplinary Computing and Complex BioSystems Group, School of Computing Science, Newcastle University, Newcastle upon Tyne, NE4 5TG, United Kingdom;

Personalized medicine requires that treatments adapt to not only the patient but also changing factors within each individual. Although epilepsy is a dynamic disorder characterized by pathological fluctuations in brain state, surprisingly little is known about whether and how seizures vary in the same patient. We quantitatively compared within-patient seizure network evolutions using intracranial electroencephalographic (iEEG) recordings of over 500 seizures from 31 patients with focal epilepsy (mean 16. Read More

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Modelling seizure rates rather than time to an event within clinical trials of antiepileptic drugs.

BMC Med Res Methodol 2020 04 15;20(1):84. Epub 2020 Apr 15.

Department of Molecular and Clinical Pharmacology, Clinical Sciences Centre, Aintree University Hospital, University of Liverpool, L9 7LJ & The Walton Centre NHS Foundation Trust, members of the Liverpool Health Partners, Lower Lane, Liverpool, UK.

Background: Predictive models within epilepsy are frequently developed via Cox's proportional hazards models. These models estimate risk of a specified event such as 12-month remission. They are relatively simple to produce, have familiar output, and are useful to answer questions about short-term prognosis. Read More

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