1,020 results match your criteria Seizures Simple Partial


Health-related quality of life in pediatric patients with partial onset seizures or primary generalized tonic-clonic seizures receiving adjunctive perampanel.

Epilepsy Behav 2021 May 8;118:107938. Epub 2021 Apr 8.

Eisai Inc., Woodcliff Lake, NJ, USA.

Rationale: Study 311 (E2007-G000-311; NCT02849626) was a Phase 3, multicenter, open-label single-arm study of adjunctive perampanel oral suspension in pediatric patients (aged 4 to <12 years) with partial-onset seizures (POS) (with/without secondarily generalized tonic-clonic seizures [SGTCS]) or primary generalized tonic-clonic seizures (PGTCS). Health-related quality of life (HRQoL) was an exploratory endpoint initially analyzed through simple descriptive summaries. The aim of this post hoc analysis was to provide a more thorough assessment of HRQoL. Read More

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The effect of a seminar on medical students' information acquisition of and attitudes toward epilepsy.

Epilepsy Behav 2021 03 21;116:107720. Epub 2021 Jan 21.

Istanbul University, Istanbul Medical Faculty, Department of Neurology, Istanbul, Turkey; Istanbul University Epilepsy Research Center, Istanbul, Turkey.

Aim: The aim of the present study was to investigate the effect of a brief seminar focusing on medical and social aspects of epilepsy on information acquisition of and attitudes toward epilepsy among medical school students.

Method: The sample of this pretest-posttest study consisted of 57 fifth-grade medical students. The students participated in a one-hour seminar including medical and social aspects of epilepsy. Read More

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F-FDG PET Imaging Predicts the Epileptogenic Zone Prospectively in Recurrent Cryptogenic Meningoencephalitis with Subsequent Simple Partial Visual Seizures.

Authors:
Mehdi Djekidel

J Nucl Med Technol 2021 Mar 20;49(1):92-94. Epub 2020 Nov 20.

Nuclear Medicine and Molecular Imaging, Sidra Medicine, Doha, Qatar

F-FDG PET scans have proven to be useful in the diagnosis and management of encephalitis patients. F-FDG PET scans are also the standard of care in the evaluation of epilepsy patients before surgery. Encephalitis patients who later develop epilepsy may have useful imaging findings at the time of diagnosis. Read More

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Case 284: Posterior Quadrantic Dysplasia.

Radiology 2020 12;297(3):733-737

From the Department of Diagnostic Radiology, SUNY Upstate Medical University, 750 E Adams St, Syracuse, NY 13210-2306.

History A 36-year-old left-handed woman with a history of developmental delay and medical refractory seizures since birth most recently presented with continuous simple partial seizures and occasional breakthrough complex partial seizures with postictal migraines. These were described as the patient "becoming pale with sinking to the floor and staring for approximately 1 minute with confusion thereafter." The patient had years of reported seizure freedom until 2010 when she was evaluated for intractable headaches, and electroencephalography revealed her focal subclinical status. Read More

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December 2020

COVID-19 containment and its unrestrained impact on epilepsy management in resource-limited areas of Pakistan.

Epilepsy Behav 2020 11 25;112:107476. Epub 2020 Sep 25.

Cell and Molecular Biology Laboratory, Department of Zoology, University of the Punjab, Lahore 54590, Pakistan; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China; University of Chinese Academy of Sciences, Beijing 100049, China.

The current pandemic of coronavirus disease 2019 (COVID-19) that led to an unprecedented crisis with significant health, social, and economic repercussions presented more serious concerns for those living with some chronic conditions such as epilepsy. This study was aimed to find out impact of the COVID-19 pandemic on management of epilepsy. A cross-sectional study was conducted through telephone interviews, targeting 213 caregivers of pediatric patients with epilepsy, belonging to underserved areas of Faisalabad, Punjab, Pakistan. Read More

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November 2020

Seizures with paroxysmal arousals in sleep-related hypermotor epilepsy (SHE): Dissecting epilepsy from NREM parasomnias.

Epilepsia 2020 10 19;61(10):2194-2202. Epub 2020 Sep 19.

Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.

Objective: Sleep-related hypermotor epilepsy (SHE) is a focal epilepsy characterized by seizures occurring mostly during sleep, ranging from brief seizures with paroxysmal arousals (SPAs) to hyperkinetic seizures and ambulatory behaviors. SPAs are brief and stereotypic seizures representing the beginning of a major seizure. Distinguishing SPAs from disorders of arousal (DOAs) and their briefest episodes called simple arousal movements (SAMs) is difficult. Read More

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October 2020

The Protective Effect of Breastfeeding on Febrile Seizures: A Case-Control Study.

Breastfeed Med 2020 11 3;15(11):709-714. Epub 2020 Sep 3.

Department of Pediatrics, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.

Our study was performed to analyze the interrelationship between breastfeeding for the first 6 months of life and the incidence of febrile seizures (FS). A case-control study was conducted in Renmin Hospital of Wuhan University. Three hundred thirty-six patients diagnosed with FS were enrolled as the case group, and 336 febrile children with matched age and gender were enrolled as the control group. Read More

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November 2020

The Unease When Using Anesthetics for Treatment-Refractory Status Epilepticus: Still Far Too Many Questions.

J Clin Neurophysiol 2020 Sep;37(5):399-405

Department of Intensive Care Medicine, University Hospital Basel, Basel, Switzerland.

Status epilepticus (SE), treatment-refractory status epilepticus (RSE), and super-treatment-refractory status epilepticus (SRSE) are associated with increased morbidity, mortality, and high socioeconomic burden and pose significant treatment challenges for intensivists and neurologists. To optimize and streamline emergency treatment, current practice guidelines recommend the use of continuously delivered intravenous anesthetic drugs such as midazolam, propofol, or barbiturates as the third-line therapy after first-line and second-line treatments have failed. Although the rationale for these third-line drugs seems intuitive at first glance, there is a clear paucity of evidence-based data on risks, benefits, and even on the choice of a third-line agent. Read More

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September 2020

The FDP/FIB Ratio and Blood FDP Level May Be Related to Seizures After Fever in Young Children.

Front Pediatr 2020 31;8:439. Epub 2020 Jul 31.

Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, China.

To evaluate the relationship of the blood fibrinogen (FIB) degradation product (FDP) level and FDP/FIB ratio with seizure in young children with fever. A total of 35 children with simple febrile seizures and 80 children with fever but no seizure were selected. First, the differences in white blood cell (WBC), platelets (PLT), prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT), FIB, FDP, FDP/FIB ratio, and C-reactive protein (CRP) between 35 children with simple febrile seizures and 40 randomly selected children with fever but no seizure were retrospectively analyzed. Read More

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Case 284.

Radiology 2020 08;296(2):460-462

From the Department of Diagnostic Radiology, SUNY Upstate Medical University, 750 E Adams St, Syracuse, NY 13210-2306.

History A 36-year-old left-handed woman with a history of developmental delay and medical refractory seizures since birth most recently presented with continuous simple partial seizures and occasional breakthrough complex partial seizures with postictal migraines. These were described as the patient "becoming pale with sinking to the floor and staring for approximately 1 minute with confusion thereafter." The patient had years of reported seizure freedom until 2010 when she was evaluated for intractable headaches, and electroencephalography revealed her focal subclinical status. Read More

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Surgically Treated Epilepsy due to Developmental Venous Anomaly of the Brain: Case Report and Review of the Literature.

Authors:
Kamran Aghayev

World Neurosurg 2020 09 12;141:119-122. Epub 2020 Jun 12.

Department of Neurosurgery, Biruni University, Istanbul, Turkey. Electronic address:

Background: A congenital malformation of the brain vessels, developmental venous anomaly (DVA) is considered a benign lesion, requiring no intervention unless symptomatic. Epilepsy is a well-known clinical manifestation of DVA. Successful surgery for DVA-associated epilepsy with has been sporadically reported in the literature; however, in all published cases, the anomaly was left intact along with the accompanying lesion. Read More

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September 2020

Which seizure elements do patients memorize? A comparison of history and seizure documentation.

Epilepsia 2020 07 9;61(7):1365-1375. Epub 2020 Jun 9.

Epilepsy Center, University Medical Center, University of Freiburg, Freiburg, Germany.

Objective: People with epilepsy (PWE) are frequently unable to recall the core manifestation of their disease, epileptic seizures. This means that seizure frequency is often underestimated by practitioners and that seizure classification based on reports of patients or their relatives is difficult because seizure semiology remains unclear. The purpose of this study, therefore, was to prospectively explore patients' memory regarding seizure elements and to assess the role of seizure types. Read More

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Mechanical Thrombectomy for Cerebral Venous Sinus Thrombosis: A Case Series and Technical Note.

World Neurosurg 2020 08 8;140:148-161. Epub 2020 May 8.

Division of Neuroradiology, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada; Division of Neurosurgery, Department of Surgery, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada.

Background: Cerebral venous sinus thrombosis is a rare cause of acute stroke. It may lead to hemorrhagic venous infarctions, brain swelling, or raised intracranial pressure and can be associated with significant mortality and morbidity. Low-molecular-weight heparin is the mainstay of treatment. Read More

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Seizure pathways change on circadian and slower timescales in individual patients with focal epilepsy.

Proc Natl Acad Sci U S A 2020 05 4;117(20):11048-11058. Epub 2020 May 4.

Interdisciplinary Computing and Complex BioSystems Group, School of Computing Science, Newcastle University, Newcastle upon Tyne, NE4 5TG, United Kingdom;

Personalized medicine requires that treatments adapt to not only the patient but also changing factors within each individual. Although epilepsy is a dynamic disorder characterized by pathological fluctuations in brain state, surprisingly little is known about whether and how seizures vary in the same patient. We quantitatively compared within-patient seizure network evolutions using intracranial electroencephalographic (iEEG) recordings of over 500 seizures from 31 patients with focal epilepsy (mean 16. Read More

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Efficacy and safety of eslicarbazepine acetate as adjunctive therapy for refractory focal-onset seizures in children: A double-blind, randomized, placebo-controlled, parallel-group, multicenter, phase-III clinical trial.

Epilepsy Behav 2020 04 6;105:106962. Epub 2020 Mar 6.

BIAL - Portela & Cª. S.A., S. Mamede do Coronado, Portugal; Department of Biomedicine, Pharmacology and Therapeutics Unit, Faculty of Medicine, University Porto, Porto, Portugal; MedInUP - Center for Drug Discovery and Innovative Medicines, University Porto, Porto, Portugal. Electronic address:

Purpose: This was a phase-III, randomized, double-blind, placebo-controlled study aimed to evaluate efficacy and tolerability of eslicarbazepine acetate (ESL) as adjunctive therapy in pediatric patients with refractory focal-onset seizures (FOS).

Methods: Children (2-18 years old) with FOS, receiving 1-2 antiepileptic drugs, were randomized to ESL or placebo. Treatment was started at 10 mg/kg/day, up-titrated up to 20-30 mg/kg/day, and maintained for 12 weeks, followed by one-year open-label follow-up. Read More

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EEG based multi-class seizure type classification using convolutional neural network and transfer learning.

Neural Netw 2020 Apr 25;124:202-212. Epub 2020 Jan 25.

Department of Neurosurgery, Maastricht University Medical Center, Maastricht, The Netherlands.

Recognition of epileptic seizure type is essential for the neurosurgeon to understand the cortical connectivity of the brain. Though automated early recognition of seizures from normal electroencephalogram (EEG) was existing, no attempts have been made towards the classification of variants of seizures. Therefore, this study attempts to classify seven variants of seizures with non-seizure EEG through the application of convolutional neural networks (CNN) and transfer learning by making use of the Temple University Hospital EEG corpus. Read More

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A convolutional neural network based framework for classification of seizure types.

Annu Int Conf IEEE Eng Med Biol Soc 2019 Jul;2019:2547-2550

Epileptic seizures are caused by a disturbance in the electrical activity of the brain and classified as many different types of epileptic seizures based on the characteristics of EEG and other parameters. Till now research has been conducted to classify EEG as seizure and non-seizures, but the classification of seizure types has not been explored. Thus, in this paper, we have proposed the 8-class classification problem in order to classify different seizure types using convolutional neural networks (CNN). Read More

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Development and Validation of an UHPLC-MS/MS Assay for the Therapeutic Monitoring of Brivaracetam Plasma Concentrations in Patients with Epilepsy.

Ther Drug Monit 2020 06;42(3):445-451

IRCCS-Istituto delle Scienze Neurologiche di Bologna; and.

Background: Brivaracetam is an antiepileptic drug used as an add-on therapy for partial-onset seizures in subjects aged 4 years and older. Owing to potential drug interactions and intersubject variability in plasma concentrations, therapeutic monitoring for brivaracetam may be useful. The aim of this study was to develop a simplified method for measuring brivaracetam plasma concentrations applicable to therapeutic drug monitoring in epilepsy. Read More

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Trazodone increases seizures in a genetic WAG/Rij rat model of absence epilepsy while decreasing them in penicillin-evoked focal seizure model.

Authors:
Hatice Aygun

Epilepsy Behav 2020 02 18;103(Pt A):106847. Epub 2019 Dec 18.

Department of Physiology, Faculty of Medicine, Tokat Gaziosmanpasa University, Tokat, Turkey. Electronic address:

Aim: Psychiatric disorders, especially depression and anxiety, are among the most disabling comorbidities in patients with epilepsy, and they are difficult to treat because many antidepressants cause proconvulsive effects. Thus, it is important to identify the seizure risks associated with antidepressants. Trazodone is one of the most frequently prescribed selective serotonin reuptake inhibitor (SSRI) antidepressant drugs for the treatment of depression and anxiety. Read More

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February 2020

Nonketotic Hyperglycemia-related Seizures of Left Parieto-occipital Origin: A Case Report.

J Neurosci Nurs 2020 Feb;52(1):27-29

Introduction: Nonketotic hyperglycemia-related seizures are not uncommonly encountered in clinical practice. Their presentation varies, and they may cause serious consequences if they remain unnoticed.

Case: We report a case of nonketotic hyperglycemia-related seizures of unique left parieto-occipital origin and semiology, presenting as focal aware (simple partial) and impaired awareness (complex partial) seizures, including contralateral limb convulsion and apraxialike behavior. Read More

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February 2020

Epileptic seizure semiology in infants and children.

Seizure 2020 Apr 24;77:3-6. Epub 2019 Oct 24.

Rainbow Babies & Children's Hospital, Cleveland, Ohio, United States; Epilepsy Center, University Hospitals, Cleveland, Ohio, United States; Case Western Reserve University School of Medicine, Cleveland, Ohio, United States. Electronic address:

Epileptic seizure semiology adds important information to the formulation of the hypothesis of the epileptogenic zone. Seizure semiology in infants and children are simple and elementary, becoming more complex with maturation of brain. Also in this age group, seizure semiology may be generalized in a setting of a focal lesion or may show focal signs with misleading localization values. Read More

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Thymoma associated paraneoplastic encephalitis (TAPE), a potential cause of limbic encephalitis.

BMJ Case Rep 2019 Aug 30;12(8). Epub 2019 Aug 30.

Division of Infectious Diseases, California Pacific Medical Center, San Francisco, California, USA.

A 59-year-old man presents with expressive aphasia and short term memory deficits. Shortly thereafter, he started developing staring spells and intermittent right hand spasms, preliminarily thought to be simple partial seizures. Subsequent MRI brain imaging was highly suggestive of herpes simplex virus (HSV) encephalitis; however, HSV PCR from cerebrospinal fluid was negative. Read More

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Misdiagnosis and pitfalls in Panayiotopoulos syndrome.

Epilepsy Behav 2019 09 29;98(Pt A):124-128. Epub 2019 Jul 29.

Child Neurology, NESMOS Department, Faculty of Medicine & Psychology, "Sapienza" University, c/o Sant'Andrea Hospital, Rome, Italy. Electronic address:

Panayiotopoulos syndrome (PS) is a frequent (6% among children of 1-15 years) and benign epileptic syndrome, characterized by predominantly autonomic symptoms (emesis, pallor, flushing, cyanosis, mydriasis/miosis, cardiorespiratory and thermoregulatory alterations, incontinence of urine and/or feces, hypersalivation, and modifications of intestinal motility) associated with simple motor focal seizures, which can be followed by secondary generalization. Panayiotopoulos syndrome can be extremely insidious, because it can mimic several condition, such as gastroenteritis, gastroesophageal reflux disease, encephalitis, syncope, migraine, sleep disorders, or even metabolic diseases. This peculiar pleiotropism should be kept in mind by child neurologists and pediatricians and general practitioners, because a wrong diagnosis may lead to inappropriate interventions. Read More

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September 2019

Gross Total Resection of a Grade IV Astrocytoma Adjacent to the Precentral Gyrus With Nonawake Motor Mapping and Motor-Evoked Potential Monitoring: 3-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2020 Apr;18(4):E127-E128

Department of Neurological Surgery, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin.

Surgical treatment of the gliomas located in or adjacent to the eloquent areas poses significant challenge to neurosurgeons. The main goal of the surgery is to achieve maximal safe resection while preserving the neurological function. This might be possible with utilizing pre- and intraoperative adjuncts such as functional magnetic resonance imaging (MRI), image guidance, mapping of the function of interest, intraoperative MRI, and neurophysiological monitoring. Read More

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Electroacupuncture Reduces Seizure Activity and Enhances GAD 67 and Glutamate Transporter Expression in Kainic Acid Induced Status Epilepticus in Infant Rats.

Behav Sci (Basel) 2019 Jun 27;9(7). Epub 2019 Jun 27.

Unidad de Investigación Médica en Enfermedades Neurológicas, Hospital de Especialidades "Dr. Bernardo Sepúlveda", Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social (IMSS), Ciudad de México CP.06720, Mexico.

Status epilepticus (SE) is one of the most significant complications in pediatric neurology. Clinical studies have shown positive effects of electroacupuncture (EA) as a therapeutic alternative in the control of partial seizures and secondary generalized clonic seizures. EA promotes the release of neurotransmitters such as GABA and some opioids. Read More

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Topiramate versus carbamazepine monotherapy for epilepsy: an individual participant data review.

Cochrane Database Syst Rev 2019 06 24;6:CD012065. Epub 2019 Jun 24.

Department of Biostatistics, University of Liverpool, Block F, Waterhouse Building, 1-5 Brownlow Hill, Liverpool, UK, L69 3GL.

Background: This is an updated version of the original Cochrane Review published in Issue 12, 2016. This review is one in a series of Cochrane Reviews investigating pair-wise monotherapy comparisons.Epilepsy is a common neurological condition in which abnormal electrical discharges from the brain cause recurrent unprovoked seizures. Read More

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Treatable cause of hereditary spastic paraplegia: eight cases of combined homocysteinaemia with methylmalonic aciduria.

J Neurol 2019 Oct 15;266(10):2434-2439. Epub 2019 Jun 15.

Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Shuaifuyuan 1, Dongcheng district, Beijing, 100730, China.

Combined homocysteinemia with methylmalonic aciduria (MMA/HCY) are genetic disorders of intracellular cobalamin (cbl) transport and processing that cause downstream deficiencies in methylcobalamin and adenosylcobalamin. Untreated disease is characterized biochemically by methylmalonic aciduria and hyperhomocysteinemia, while the clinical features are variable. When spastic paraplegia (SP) dominates, it is difficult to differentiate from hereditary spastic paraplegia (HSP). Read More

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October 2019