986 results match your criteria Seizures Simple Partial


Tonic Seizure as a Different Seizure Type Presented in Autoimmune Epilepsy Caused by Systemic Lupus Erythematosus.

J Nerv Ment Dis 2019 Feb 6. Epub 2019 Feb 6.

Department of Neurology, Department of Neurology and Neuroscience Center, The First Hospital of JiLin University, Changchun, People's Republic of China.

The diagnosis of autoimmune epilepsy is often challenging, and may be misdiagnosed as epileptic disorders or viral encephalitis. Autoimmune epilepsy has a strong association with other autoimmune diseases, especially systemic lupus erythematosus (SLE). In addition, autoimmune epilepsy was reported to present with complex partial seizure (CPS), simple partial seizure (SPS), and secondarily generalized tonic-clonic seizure (sGTCS). Read More

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http://dx.doi.org/10.1097/NMD.0000000000000946DOI Listing
February 2019
1 Read

Health utilities and quality of life in individuals with tuberous sclerosis complex (TSC) who experience epileptic seizures: A web-based survey.

Epilepsy Behav 2019 Jan 25;92:213-220. Epub 2019 Jan 25.

St George's Hospital, Blackshaw Road, London SW17 0QT, United Kingdom.

Objectives: Individuals with tuberous sclerosis complex (TSC) experience a wide range of health impacts, including epileptic seizures, negatively impacting their health-related quality of life (HRQoL). Health state utility values (HSUVs) are index values representing HRQoL and are used as key inputs for health economic analyses. Such data are currently very limited in the TSC population. Read More

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http://dx.doi.org/10.1016/j.yebeh.2018.11.021DOI Listing
January 2019
1 Read

Seizures After Stereotactic Radiosurgery for Benign Supratentorial Meningiomas: An Uncontrollable Type of Seizure?

World Neurosurg 2018 Dec 5. Epub 2018 Dec 5.

Department of Neurosurgery, Seoul National University Bundang Hospital, Seongnam-si, Republic of Korea; Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Republic of Korea. Electronic address:

Objective: We investigated seizure outcomes of patients with supratentorial meningiomas (ST-MNGs) treated with stereotactic radiosurgery (SRS).

Methods: One hundred and thirty-three patients with a total of 144 ST-MNGs, who were treated with SRS between 2009 and 2016, were included in this study. The mean age was 59. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.11.211DOI Listing
December 2018
2 Reads

Focal Electrographic Seizures in a Patient With Autism Spectrum Disorder and Speech Delay.

J Dev Behav Pediatr 2018 Dec;39(9):763-765

Boston University School of Medicine, Division of Developmental and Behavioral Pediatrics, Boston Medical Center, Boston, MA.

Case: A 6-year-old boy with a diagnosis of autism spectrum disorder (ASD) presented to primary care for a new-patient, transfer-of-care evaluation. At the initial encounter, the patient used a maximum of 60 words and was receiving speech and language therapy (SLT) through school. Family history was positive for seizures in the father and paternal grandfather as well as ASD in an older brother. Read More

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http://dx.doi.org/10.1097/DBP.0000000000000631DOI Listing
December 2018
7 Reads

Carbamazepine versus phenobarbitone monotherapy for epilepsy: an individual participant data review.

Cochrane Database Syst Rev 2018 10 24;10:CD001904. Epub 2018 Oct 24.

Department of Biostatistics, University of Liverpool, Block F, Waterhouse Building, 1-5 Brownlow Hill, Liverpool, UK, L69 3GL.

Background: This is an updated version of the Cochrane Review previously published in 2016. This review is one in a series of Cochrane Reviews investigating pair-wise monotherapy comparisons.Epilepsy is a common neurological condition in which abnormal electrical discharges from the brain cause recurrent unprovoked seizures. Read More

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http://doi.wiley.com/10.1002/14651858.CD001904.pub4
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http://dx.doi.org/10.1002/14651858.CD001904.pub4DOI Listing
October 2018
10 Reads

Awake craniotomy without sedation in treatment of patients with lesional epilepsy.

Surg Neurol Int 2018 3;9:177. Epub 2018 Sep 3.

Federal Centre of Treatment and Rehabilitation of Ministry of Healthcare of Russian Federation, 125367 Moscow, Russia.

Background: The use of awake craniotomy for surgical treatment of epilepsy was applied in surgery of convexital tumors, arteriovenous malformations, some superficial aneurysms, and stereotactic neurosurgery. The aim of this study was to show the advantages of awake craniotomy without sedation, accompanied by intraoperative neurophysiological monitoring in patients with symptomatic epilepsy.

Methods: This article describes the results of surgical treatment in 41 patients with various pathologies; 31 among them suffered from epilepsy. Read More

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http://dx.doi.org/10.4103/sni.sni_24_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130149PMC
September 2018
4 Reads

Bilateral stereotactic lesions and chronic stimulation of the anterior thalamic nuclei for treatment of pharmacoresistant epilepsy.

Surg Neurol Int 2018 19;9:137. Epub 2018 Jul 19.

Federal Centre of Treatment and Rehabilitation of Ministry of Healthcare of Russian Federation, Ivankovskoe, Moscow, Russia.

Background: The use of the anterior nucleus of thalamus (ANT) as a target for treatment of pharmacoresistant epilepsy is based on its crucial role in seizure propagation. We describe results of chronic bilateral ANT stimulation and bilateral ANT lesions in 31 patients with refractory epilepsy.

Methods: ANT DBS was performed in 12 patients (group I) and bilateral stereotactic radiofrequency lesions of ANT were performed in 19 patients (group II). Read More

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http://dx.doi.org/10.4103/sni.sni_25_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6069370PMC

Sodium valproate versus phenytoin monotherapy for epilepsy: an individual participant data review.

Cochrane Database Syst Rev 2018 08 9;8:CD001769. Epub 2018 Aug 9.

Department of Biostatistics, University of Liverpool, Block F, Waterhouse Building, 1-5 Brownlow Hill, Liverpool, UK, L69 3GL.

Background: Epilepsy is a common neurological condition in which abnormal electrical discharges from the brain cause recurrent unprovoked seizures. It is believed that with effective drug treatment up to 70% of individuals with active epilepsy have the potential to become seizure-free, and to go into long-term remission shortly after starting drug therapy with a single antiepileptic drug in monotherapy.Worldwide, sodium valproate and phenytoin are commonly used antiepileptic drugs for monotherapy treatment. Read More

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http://doi.wiley.com/10.1002/14651858.CD001769.pub4
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http://dx.doi.org/10.1002/14651858.CD001769.pub4DOI Listing
August 2018
1 Read

[A case series of 4 epilepsy patients with promnesia].

Rinsho Shinkeigaku 2018 Aug 31;58(8):513-516. Epub 2018 Jul 31.

Department of Neurology, Kyoto University Graduate School of Medicine.

Promnesia is a feeling of familiarity and foreknowledge and is a manifestation of simple partial seizures (focal aware seizures). It is similar to déjà vu and has been reported to be a rare symptom in patients with temporal lobe epilepsy. Here, we investigated the clinical characteristics in 4 patients with partial epilepsy presenting promnesia. Read More

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http://dx.doi.org/10.5692/clinicalneurol.cn-001149DOI Listing
August 2018
3 Reads

Automated Detection of Convulsive Seizures Using a Wearable Accelerometer Device.

IEEE Trans Biomed Eng 2018 Jun 11. Epub 2018 Jun 11.

Epileptic seizure detection requires specialized approaches such as video/electroencephalography monitoring. However, these approaches are restricted mainly to hospital setting and requires video/EEG analysis by experts, which makes these approaches resource- and labor-intensive. In contrast, we aim to develop a wireless remote monitoring system based on a single wrist-worn accelerometer device, which is sensitive to multiple types of convulsive seizures and is capable of detecting seizures with short duration. Read More

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http://dx.doi.org/10.1109/TBME.2018.2845865DOI Listing
June 2018
20 Reads
2.347 Impact Factor

Automated Detection of Convulsive Seizures Using a Single Wrist-Worn Accelerometer Device.

IEEE Trans Biomed Eng 2018 Jun 11. Epub 2018 Jun 11.

Epileptic seizure detection requires specialized approaches such as video/electroencephalography monitoring. However, these approaches are restricted mainly to hospital setting and requires video/EEG analysis by experts, which makes these approaches resource- and labor-intensive. In contrast, we aim to develop a wireless, remote monitoring system using a single wrist-worn accelerometer sensor, which is sensitive to multiple types of convulsive seizures and is capable of detecting seizures with short duration. Read More

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http://dx.doi.org/10.1109/TBME.2018.2845865DOI Listing
June 2018
22 Reads
2.347 Impact Factor

Lamotrigine versus carbamazepine monotherapy for epilepsy: an individual participant data review.

Cochrane Database Syst Rev 2018 06 28;6:CD001031. Epub 2018 Jun 28.

Department of Biostatistics, University of Liverpool, Block F, Waterhouse Building, 1-5 Brownlow Hill, Liverpool, UK, L69 3GL.

Background: This is an updated version of the original Cochrane Review published in Issue 11, 2006 of the Cochrane Database of Systematic Reviews.Epilepsy is a common neurological condition in which abnormal electrical discharges from the brain cause recurrent unprovoked seizures. It is believed that with effective drug treatment up to 70% of individuals with active epilepsy have the potential to become seizure-free, and to go into long-term remission shortly after starting drug therapy with a single antiepileptic drug (AED) in monotherapy. Read More

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http://dx.doi.org/10.1002/14651858.CD001031.pub4DOI Listing
June 2018
2 Reads

[Classification of seizures and epilepsies].

Lakartidningen 2018 05 21;115. Epub 2018 May 21.

Karolinska Institutet Department of Clinical Neuroscience - Stockholm, Sweden Karolinska Institutet Department of Clinical Neuroscience - Stockholm, Sweden.

In 2017 the International League Against Epilepsy (ILAE) published position papers outlining new classifications of seizures and epilepsies. The aims of the new documents are to encompass advances in the field, provide a conceptual framework for future developments, and facilitate communication. In practice, the terminology is somewhat revised. Read More

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May 2018
1 Read

The long-term outcomes of epilepsy surgery.

PLoS One 2018 16;13(5):e0196274. Epub 2018 May 16.

The Walton Centre, NHS Foundation Trust, Liverpool, Merseyside, United Kingdom.

Objective: Despite modern anti-epileptic drug treatment, approximately 30% of epilepsies remain medically refractory and for these patients, epilepsy surgery may be a treatment option. There have been numerous studies demonstrating good outcome of epilepsy surgery in the short to median term however, there are a limited number of studies looking at the long-term outcomes. The aim of this study was to ascertain the long-term outcome of resective epilepsy surgery in a large neurosurgery hospital in the U. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0196274PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5955551PMC
August 2018
4 Reads

Febrile Infection-Related Epilepsy Syndrome (FIRES): An Overview of Treatment and Recent Patents.

Recent Pat Inflamm Allergy Drug Discov 2018 ;12(2):128-135

Department of Pediatrics, Division of Child Neurology, Boston Medical Center, Boston University School of Medicine, Boston, MA 02118, United States.

Background: New-Onset Refractory Status Epilepticus (NORSE) refers to a clinical presentation in a patient without active epilepsy or other existing relevant neurological disorder, with new onset of refractory status epilepticus in the absence of a clear acute or active structural, metabolic, or toxic cause. Febrile Infection-Related Epilepsy Syndrome (FIRES) is a subset of NORSE that requires a febrile infection between 24 hours and 2 weeks prior to the onset of refractory status epilepticus, with or without fever at the onset of status epilepticus, and with no restriction to the age of the patient. The literature on FIRES is scarce. Read More

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http://dx.doi.org/10.2174/1872213X12666180508122450DOI Listing
December 2018
4 Reads
1 Citation

Averaging in time-frequency domain reveals the temporal and spatial extent of seizures recorded by scalp EEG.

Epileptic Disord 2018 Apr;20(2):132-138

Hôpital Erasme - ULB. Cliniques universitaires de Bruxelles. Route de Lennik 808 - B - 1070 Bruxelles, Belgium.

To demonstrate the importance of averaging in time-frequency space and the added localizing value in time and space in a case of cortical myoclonus. One hundred myoclonic jerks were averaged in time series and in spectral domain. For the latter, we chose 100 (10-second) segments from interictal background and used the unpaired t-test for the jerk-related and control spectral data to obtain the t value and corresponding p value at each pixel. Read More

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http://dx.doi.org/10.1684/epd.2018.0962DOI Listing
April 2018
1 Read

Determination of topiramate by capillary electrophoresis with capacitively-coupled contactless conductivity detection: A powerful tool for therapeutic monitoring in epileptic patients.

Electrophoresis 2018 Oct 25;39(20):2598-2604. Epub 2018 Apr 25.

Department of Chemistry, Clemson University, Clemson, SC, USA.

Topiramate (TPM) is the main antiepileptic drug used for the control of partial and generalized seizures in both adults and children. In association with clinical observations, the analysis of plasmatic concentration of TPM is of utmost importance for the individual adjustment of the administered dose to the patient. In the present work, a bioanalytical method was developed and validated for TPM analysis in plasma samples by capillary electrophoresis with capacitively-coupled contactless conductivity detection (CE-C D). Read More

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http://dx.doi.org/10.1002/elps.201800046DOI Listing
October 2018
2 Reads

Oxcarbazepine oral suspension in young pediatric patients with partial seizures and/or generalized tonic-clonic seizures in routine clinical practice in China: a prospective observational study.

World J Pediatr 2018 06 20;14(3):280-289. Epub 2018 Feb 20.

The third Department of Neurology, Guangdong 999 Brain Hospital, Guangzhou, China.

Background: This study aimed to assess efficacy and safety of oxcarbazepine (OXC) oral suspension in pediatric patients aged 2-5 years with partial seizures (PS) and/or generalized tonic-clonic seizures (GTCS) in real-world clinical practice in China.

Methods: This 26-week, prospective, single-arm, multicenter, observational study recruited pediatric patients aged 2-5 years with PS or GTCS suitable for OXC oral suspension treatment based on physicians' judgments from 11 medical centers in China. Enrolled subjects started OXC oral suspension treatment as monotherapy or in combination with other antiepileptic drugs. Read More

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http://dx.doi.org/10.1007/s12519-017-0114-6DOI Listing
June 2018
13 Reads

A Novel RNA Editing Sensor Tool and a Specific Agonist Determine Neuronal Protein Expression of RNA-Edited Glycine Receptors and Identify a Genomic APOBEC1 Dimorphism as a New Genetic Risk Factor of Epilepsy.

Front Mol Neurosci 2017 11;10:439. Epub 2018 Jan 11.

Division Cell Physiology, Zoological Institute, Technische Universität Braunschweig, Braunschweig, Germany.

C-to-U RNA editing of glycine receptors (GlyR) can play an important role in disease progression of temporal lobe epilepsy (TLE) as it may contribute in a neuron type-specific way to neuropsychiatric symptoms of the disease. It is therefore necessary to develop tools that allow identification of neuron types that express RNA-edited GlyR protein. In this study, we identify NH as agonist of C-to-U RNA edited GlyRs. Read More

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http://dx.doi.org/10.3389/fnmol.2017.00439DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768626PMC
January 2018
7 Reads

The production of IL-6 in acute epileptic seizure: A video-EEG study.

J Neuroimmunol 2018 Mar 15;316:50-55. Epub 2017 Dec 15.

Department of Neurology, Tampere University Hospital, Tampere, Finland; Department of Neurology, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.

Experimental and clinical reports highlight the role of cytokines in pathophysiological processes in underpinning epilepsy, but the clinical data remains somewhat limited. The levels of Interleukin (IL)-6 were measured in serum from 49 patients with refractory epilepsy [temporal lobe epilepsy (TLE, n=23), extratemporal lobe epilepsy (XLE, n=22), and idiopathic generalized epilepsy (IGE, n=4)] before and after the first verified seizure (IS; index seizure) during inpatient video-electroencephalographic (VEEG) monitoring. The levels of IL-6 increased significantly at all time points between 3h and 24h after the IS compared to the baseline. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2017.12.008DOI Listing
March 2018
8 Reads

Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data.

Cochrane Database Syst Rev 2017 12 15;12:CD011412. Epub 2017 Dec 15.

Department of Biostatistics, University of Liverpool, Block F, Waterhouse Building, 1-5 Brownlow Hill, Liverpool, UK, L69 3GL.

Background: Epilepsy is a common neurological condition with a worldwide prevalence of around 1%. Approximately 60% to 70% of people with epilepsy will achieve a longer-term remission from seizures, and most achieve that remission shortly after starting antiepileptic drug treatment. Most people with epilepsy are treated with a single antiepileptic drug (monotherapy) and current guidelines from the National Institute for Health and Care Excellence (NICE) in the United Kingdom for adults and children recommend carbamazepine or lamotrigine as first-line treatment for partial onset seizures and sodium valproate for generalised onset seizures; however a range of other antiepileptic drug (AED) treatments are available, and evidence is needed regarding their comparative effectiveness in order to inform treatment choices. Read More

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http://dx.doi.org/10.1002/14651858.CD011412.pub3DOI Listing
December 2017
31 Reads

Auras and the risk of seizures with impaired consciousness following epilepsy surgery: implications for driving.

J Neurol Neurosurg Psychiatry 2018 Jun 9;89(6):599-602. Epub 2017 Dec 9.

Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, UK.

Objective: To calculate the chance of a seizure in the next year (COSY) for seizures with impaired awareness in those experiencing auras only, those with no seizures and those with continuing seizures. Epilepsy surgery is an effective treatment for refractory focal epilepsy. Driving is an important factor affecting quality of life. Read More

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http://dx.doi.org/10.1136/jnnp-2017-316578DOI Listing
June 2018
1 Read

Understanding variability in driving recommendations for patients with seizures.

Epilepsy Behav 2017 12 5;77:44-49. Epub 2017 Nov 5.

Department of Neurology, North Shore University Hospital, Hofstra Northwell School of Medicine, 300 Community Drive, Manhasset, NY 11030, USA. Electronic address:

Background: There is lack of consensus regarding driving restrictions for patients with epilepsy. Regulations vary by state. New York State (NYS) recommends driving restrictions for one year in a person with an episode of loss of consciousness (LOC), with physician discretion. Read More

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http://dx.doi.org/10.1016/j.yebeh.2017.09.019DOI Listing
December 2017
11 Reads

Aphasic status epilepticus as the sole symptom of epilepsy: A case report and literature review.

Exp Ther Med 2017 Oct 21;14(4):3501-3506. Epub 2017 Aug 21.

Department of Neurosurgery, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China.

Aphasia is a common symptom encountered by neurologists. However, the presence of aphasia as the sole manifestation of partial status epilepticus is rare. The present study reports a case of aphasic status epilepticus in a 27-year-old right-handed female who presented after the abrupt onset of aphasia, which had persisted for 1. Read More

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http://dx.doi.org/10.3892/etm.2017.4979DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5639272PMC
October 2017
4 Reads

Risk of post-traumatic epilepsy after severe head injury in patients with at least one seizure.

Neuropsychiatr Dis Treat 2017 30;13:2301-2306. Epub 2017 Aug 30.

Department of Functional Neurosurgery, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.

Background: To explore the incidence and risk factors, including type of seizures for post-traumatic epilepsy (PTE) after severe traumatic brain injury (TBI).

Subjects And Methods: This was a retrospective follow-up study of patients discharged from Liaocheng People's Hospital between March 2011 and June 2015 with a diagnosis of post-traumatic seizures. Risk factors for PTE were evaluated in 68 inpatients by using Kaplan-Meier curves and the Cox model. Read More

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http://dx.doi.org/10.2147/NDT.S141486DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5587192PMC
August 2017
5 Reads

Seizure outcome after hippocampal deep brain stimulation in patients with refractory temporal lobe epilepsy: A prospective, controlled, randomized, double-blind study.

Epilepsia 2017 10 26;58(10):1728-1733. Epub 2017 Jul 26.

Mario Covas Hospital, Santo Andre, São Paulo, SP, Brazil.

Objective: We designed a prospective, randomized, controlled, double-blind study to evaluate the efficacy of hippocampal deep brain stimulation (Hip-DBS) in patients with refractory temporary lobe epilepsy (TLE).

Methods: Sixteen adult patients with refractory TLE were studied. Patient's workup included medical history, interictal and ictal electroencephalography (EEG), and high-resolution 1. Read More

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http://dx.doi.org/10.1111/epi.13860DOI Listing
October 2017
12 Reads

A case of epilepsy induced by eating or by visual stimuli of food made of minced meat.

Rinsho Shinkeigaku 2017 08 22;57(8):430-435. Epub 2017 Jul 22.

Department of Neurology, Kyoto University Graduate School of Medicine.

We report a 34-year-old woman with eating epilepsy induced not only by eating but also seeing foods made of minced meat. In her early 20s of age, she started having simple partial seizures (SPS) as flashback and epigastric discomfort induced by particular foods. When she was 33 years old, she developed SPS, followed by secondarily generalized tonic-clonic seizure (sGTCS) provoked by eating a hot dog, and 6 months later, only seeing the video of dumpling. Read More

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http://dx.doi.org/10.5692/clinicalneurol.cn-001001DOI Listing
August 2017
7 Reads

Smoking prevalence and seizure control in Chinese males with epilepsy.

Epilepsy Behav 2017 08 8;73:268-272. Epub 2017 Jul 8.

Department of Neurology, West China Hospital, Sichuan University, Chengdu, China. Electronic address:

Smoking has a negative effect on most diseases, yet it is under-investigated in people with epilepsy; thus its role is not clear in the general population with epilepsy. We performed a retrospective pilot study on males with epilepsy to determine the smoking rate and its relationship with seizure control using univariate analysis to calculate odds ratios (ORs) and also used a multi-variate logistic regression model. The smoking rate in our sample of 278 individuals was 25. Read More

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http://dx.doi.org/10.1016/j.yebeh.2017.04.008DOI Listing
August 2017
4 Reads

Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data.

Cochrane Database Syst Rev 2017 06 29;6:CD011412. Epub 2017 Jun 29.

Department of Biostatistics, University of Liverpool, Block F, Waterhouse Building, 1-5 Brownlow Hill, Liverpool, UK, L69 3GL.

Background: Epilepsy is a common neurological condition with a worldwide prevalence of around 1%. Approximately 60% to 70% of people with epilepsy will achieve a longer-term remission from seizures, and most achieve that remission shortly after starting antiepileptic drug treatment. Most people with epilepsy are treated with a single antiepileptic drug (monotherapy) and current guidelines from the National Institute for Health and Care Excellence (NICE) in the United Kingdom for adults and children recommend carbamazepine or lamotrigine as first-line treatment for partial onset seizures and sodium valproate for generalised onset seizures; however a range of other antiepileptic drug (AED) treatments are available, and evidence is needed regarding their comparative effectiveness in order to inform treatment choices. Read More

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http://dx.doi.org/10.1002/14651858.CD011412.pub2DOI Listing
June 2017
51 Reads

Quality of life, mood and seizure control in patients with brain tumor related epilepsy treated with lacosamide as add-on therapy: A prospective explorative study with a historical control group.

Epilepsy Behav 2017 08 14;73:83-89. Epub 2017 Jun 14.

Biostatistic Unit, Regina Elena National Cancer Institute, Via Elio Chianesi 53, Rome, Italy.

Objective: Brain tumor-related epilepsy (BTRE) is often drug resistant and patients can be forced to take polytherapy that can adversely affect their quality of life (QoL). Lacosamide (LCM) is a new antiepileptic drug (AED) used as adjunctive therapy in patients with partial seizures with or without secondary generalization, with a favorable pharmacokinetic profile that seems to be effective and well tolerated. Therefore it represents a possible therapeutic choice for patients with BTRE. Read More

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http://dx.doi.org/10.1016/j.yebeh.2017.05.031DOI Listing
August 2017
11 Reads

Hypothalamic hamartoma: Neuropathology and epileptogenesis.

Epilepsia 2017 06;58 Suppl 2:22-31

Hypothalamic Hamartoma Program and Division of Neurology, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, Arizona, U.S.A.

Hypothalamic hamartomas (HHs) are congenital malformations of the ventral hypothalamus resulting in treatment-resistant epilepsy and are intrinsically epileptogenic for the gelastic seizures that are the hallmark symptom of this disorder. This paper reviews the neuropathologic features of HHs associated with epilepsy, with an emphasis on characterizing neuron phenotypes and an ultimate goal of understanding the cellular model of ictogenesis occurring locally within this tissue. We also present previously unpublished findings on Golgi staining of HH. Read More

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http://dx.doi.org/10.1111/epi.13752DOI Listing
June 2017
25 Reads

Familial aggregation of focal seizure semiology in the Epilepsy Phenome/Genome Project.

Neurology 2017 Jul 31;89(1):22-28. Epub 2017 May 31.

From the Department of Neurology and G.H. Sergievsky Center (S.T., M.R.W.), Columbia University, New York, NY; Department of Neurology (R.F.), University of California, San Francisco; and Department of Neurology (C.S.), Boston Children's Hospital, MA.

Objective: To improve phenotype definition in genetic studies of epilepsy, we assessed the familial aggregation of focal seizure types and of specific seizure symptoms within the focal epilepsies in families from the Epilepsy Phenome/Genome Project.

Methods: We studied 302 individuals with nonacquired focal epilepsy from 149 families. Familial aggregation was assessed by logistic regression analysis of relatives' traits (dependent variable) by probands' traits (independent variable), estimating the odds ratio for each symptom in a relative given presence vs absence of the symptom in the proband. Read More

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http://dx.doi.org/10.1212/WNL.0000000000004052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5496514PMC
July 2017
6 Reads

An extent of resection threshold for seizure freedom in patients with low-grade gliomas.

J Neurosurg 2018 Apr 26;128(4):1084-1090. Epub 2017 May 26.

1Department of Neurosurgical Oncology, Barrow Brain Tumor Research Center, St. Joseph's Hospital and Medical Center, Phoenix.

OBJECTIVE Seizures are the most common presenting symptom of newly diagnosed WHO Grade II gliomas (low-grade glioma [LGG]) and significantly impair quality of life. Although gross-total resection of LGG is associated with better seizure control, it remains unclear whether an extent of resection (EOR) "threshold" exists for long-term seizure control. Specifically, what proportion of FLAIR-positive tissue in patients with newly diagnosed LGG must be removed to achieve Engel Class I seizure freedom? To clarify the EOR threshold for long-term seizure control, the authors analyzed data from a consecutive series of patients with newly diagnosed LGG who presented with seizures and subsequently underwent microsurgical resection. Read More

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http://dx.doi.org/10.3171/2016.12.JNS161682DOI Listing
April 2018
32 Reads

Multi-Regional Adaptation in Human Auditory Association Cortex.

Front Hum Neurosci 2017 9;11:247. Epub 2017 May 9.

Departments of Neurology, Johns Hopkins School of Medicine, BaltimoreMD, USA.

In auditory cortex, neural responses decrease with stimulus repetition, known as adaptation. Adaptation is thought to facilitate detection of novel sounds and improve perception in noisy environments. Although it is well established that adaptation occurs in primary auditory cortex, it is not known whether adaptation also occurs in higher auditory areas involved in processing complex sounds, such as speech. Read More

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http://dx.doi.org/10.3389/fnhum.2017.00247DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5422464PMC
May 2017
9 Reads

Refractory Lesional Parietal Lobe Epilepsy: Clinical, Electroencephalographic and Neurodiagnostic Findings.

Noro Psikiyatr Ars 2016 Sep 1;53(3):213-221. Epub 2016 Mar 1.

Department of Neurology, Hacettepe University School of Medicine, Ankara, Turkey.

Introduction: Specialized centers, in the management and surgical treatment of medically refractory epilepsy, emphasize the importance of differentiating the varieties of localization related epilepsies. There has been considerable recent interest in temporal and frontal lobe epileptic syndromes and less attention has been paid to parietal and occipital lobe epilepsies.

Methods: Here we report the clinical, electroencephalographic and neuroimaging characteristics of 46 patients with medically refractory lesional parietal lobe epilepsy who have been followed up for 1-10 years. Read More

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http://dx.doi.org/10.5152/npa.2016.13790DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378203PMC
September 2016
7 Reads

Efficacy and safety of corpus callosotomy after vagal nerve stimulation in patients with drug-resistant epilepsy.

J Neurosurg 2018 Jan 3;128(1):277-286. Epub 2017 Mar 3.

1Section of Neurosurgery, Department of Surgery.

OBJECTIVE Vagal nerve stimulation (VNS) and corpus callosotomy (CC) have both been shown to be of benefit in the treatment of medically refractory epilepsy. Recent case series have reviewed the efficacy of VNS in patients who have undergone CC, with encouraging results. There are few data, however, on the use of CC following VNS therapy. Read More

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http://dx.doi.org/10.3171/2016.10.JNS161841DOI Listing
January 2018
12 Reads

Operational classification of seizure types by the International League Against Epilepsy: Position Paper of the ILAE Commission for Classification and Terminology.

Epilepsia 2017 04 8;58(4):522-530. Epub 2017 Mar 8.

The Paediatric Neurosciences Research Group, Royal Hospital for Children, Glasgow, United Kingdom.

The International League Against Epilepsy (ILAE) presents a revised operational classification of seizure types. The purpose of such a revision is to recognize that some seizure types can have either a focal or generalized onset, to allow classification when the onset is unobserved, to include some missing seizure types, and to adopt more transparent names. Because current knowledge is insufficient to form a scientifically based classification, the 2017 Classification is operational (practical) and based on the 1981 Classification, extended in 2010. Read More

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http://dx.doi.org/10.1111/epi.13670DOI Listing
April 2017
15 Reads

A prospective study of diffusion weighted magnetic resonance imaging abnormalities in patients with cluster of seizures and status epilepticus.

Clin Neurol Neurosurg 2017 Apr 24;155:70-74. Epub 2017 Feb 24.

Department of Radiology, Nizam's Institute of Medical Sciences, Punjagutta, Hyderabad, India. Electronic address:

Objective: To study the frequency, imaging characteristics, and clinical predictors for development of periictal diffusion weighted MRI abnormalities.

Methods: We prospectively analyzed electro clinical and imaging characteristic of adult patients with cluster of seizures or status epilepticus between November 2013 and November 2015, in whom the diffusion weighted imaging was done within 24h after the end of last seizure (clinical or electrographic).

Results: There were thirty patients who fulfilled the inclusion and exclusion criteria. Read More

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http://dx.doi.org/10.1016/j.clineuro.2017.02.013DOI Listing
April 2017
2 Reads

Effects of Jasminum multiflorum leaf extract on rodent models of epilepsy, motor coordination and anxiety.

Epilepsy Res 2017 03 28;131:58-63. Epub 2017 Feb 28.

Department of Preclinical Sciences, University of the West Indies, St. Augustine, Trinidad and Tobago.

Jasmine flowers and leaves are used extensively in folk medicine in different parts of the world to treat a variety of diseases. However, there are very few published reports on the neuropsychiatric effects of Jasmine extracts. Hence, the objectives of the present study were to examine the effects of an alcohol extract of Jasminum multiflorum leaves on topically-applied bicuculline (a model of acute simple partial epilepsy) and maximal electroshock (MES, a model of generalized tonic-clonic seizure) in male Sprague-Dawley rats. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2017.02.012DOI Listing
March 2017
13 Reads

Carbamazepine versus phenytoin monotherapy for epilepsy: an individual participant data review.

Cochrane Database Syst Rev 2017 02 27;2:CD001911. Epub 2017 Feb 27.

Department of Biostatistics, University of Liverpool, Block F, Waterhouse Building, 1-5 Brownlow Hill, Liverpool, UK, L69 3GL.

Background: This is an updated version of the original Cochrane Review published in Issue 2, 2002 and its subsequent updates in 2010 and 2015.Epilepsy is a common neurological condition in which recurrent, unprovoked seizures are caused by abnormal electrical discharges from the brain. It is believed that with effective drug treatment, up to 70% of individuals with active epilepsy have the potential to become seizure-free and go into long-term remission shortly after starting drug therapy with a single antiepileptic drug in monotherapy. Read More

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http://dx.doi.org/10.1002/14651858.CD001911.pub3DOI Listing
February 2017
8 Reads

Therapeutic effects of cannabinoids in animal models of seizures, epilepsy, epileptogenesis, and epilepsy-related neuroprotection.

Epilepsy Behav 2017 05 9;70(Pt B):319-327. Epub 2017 Feb 9.

Department of Pharmacy, School of Chemistry, Food & Nutritional Sciences and Pharmacy, University of Reading, Whiteknights, Reading, Berkshire RG6 6AP, UK. Electronic address:

The isolation and identification of the discrete plant cannabinoids in marijuana revived interest in analyzing historical therapeutic claims made for cannabis in clinical case studies and anecdotes. In particular, sources as old as the 11th and 15th centuries claimed efficacy for crude marijuana extracts in the treatment of convulsive disorders, prompting a particularly active area of preclinical research into the therapeutic potential of plant cannabinoids in epilepsy. Since that time, a large body of literature has accumulated describing the effects of several of the >100 individual plant cannabinoids in preclinical models of seizures, epilepsy, epileptogenesis, and epilepsy-related neuroprotection. Read More

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http://dx.doi.org/10.1016/j.yebeh.2016.11.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651410PMC
May 2017
13 Reads

Development and validation of a reversed-phase HPLC method for licarbazepine monitoring in serum of patients under oxcarbazepine treatment.

Biomed Chromatogr 2017 Sep 10;31(9). Epub 2017 Mar 10.

Laboratory of Pharmacology, School of Medicine, University of Thessaly, Larissa, Greece.

Licarbazepine is the pharmacologically active metabolite of oxcarbazepine, a drug indicated for the treatment of partial seizures and bipolar disorders. Several HPLC methods have been developed thus far but there is lack of control for interferences from antipsychotic drugs. The aim of the present study was to develop a simple, low-cost and reliable HPLC-UV method for the determination of licarbazepine in human serum in the presence of co-administered antiepileptic, antipsychotic and commonly prescribed drugs. Read More

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http://dx.doi.org/10.1002/bmc.3950DOI Listing
September 2017
10 Reads

A case of CDKL5 disorder: improved ADL by simple treatment strategy for intractable epileptic seizures.

No To Hattatsu 2017 Jan;49(1):28-31

CDKL5 gene mutations are the cause of symptomatic infantile epilepsy in some patients. Such patients present with partial seizures and characteristic hand movements that are often observed in patients with Rett syndrome. This clinical entity has recently been recognized as CDKL5 disorder. Read More

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January 2017

Persistent Interictal Musical Hallucination in a Patient With Mesial Temporal Sclerosis-Related Epilepsy: First Case Report and Etiopathological Hypothesis.

Cogn Behav Neurol 2016 Dec;29(4):217-221

*Neurology Unit, Desio and Vimercate Hospitals, Vimercate (MB), Italy †Department of Neurosciences, Neurology Unit, "Papa Giovanni XXIII" Hospital, Bergamo (BG), Italy.

Musical hallucination is a disorder of complex sound processing of instrumental music, songs, choirs, chants, etc. The underlying pathologies include moderate to severe acquired hearing loss (the auditory equivalent of Charles Bonnet syndrome), psychiatric illnesses (depression, schizophrenia), drug intoxication (benzodiazepines, salicylate, pentoxifylline, propranolol), traumatic lesions along the acoustic pathways, and epilepsy. The hallucinations are most likely to begin late in life; 70% of patients are women. Read More

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http://dx.doi.org/10.1097/WNN.0000000000000111DOI Listing
December 2016
68 Reads

Carbamazepine versus phenobarbitone monotherapy for epilepsy: an individual participant data review.

Cochrane Database Syst Rev 2016 12 15;12:CD001904. Epub 2016 Dec 15.

Department of Biostatistics, University of Liverpool, Block F, Waterhouse Building, 1-5 Brownlow Hill, Liverpool, UK, L69 3GL.

Background: This is an updated version of the original Cochrane Review, first published in Issue 1, 2003 and updated in 2015. This review is one in a series of Cochrane Reviews investigating pair-wise monotherapy comparisons.Epilepsy is a common neurological condition in which abnormal electrical discharges from the brain cause recurrent unprovoked seizures. Read More

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http://dx.doi.org/10.1002/14651858.CD001904.pub3DOI Listing
December 2016
19 Reads

Corrigendum to "Simple partial seizures aggravated or induced by benzodiazepine injection" [Seizure 41 (2016) 6-8].

Seizure 2017 02 5;45:61. Epub 2016 Dec 5.

Department of Neurology, Epilepsy Research Institute, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.seizure.2016.10.020DOI Listing
February 2017
3 Reads

Topiramate versus carbamazepine monotherapy for epilepsy: an individual participant data review.

Cochrane Database Syst Rev 2016 12 6;12:CD012065. Epub 2016 Dec 6.

Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Clinical Sciences Centre for Research and Education, Lower Lane, Fazakerley, Liverpool, Merseyside, UK, L9 7LJ.

Background: Epilepsy is a common neurological condition in which abnormal electrical discharges from the brain cause recurrent unprovoked seizures. It is believed that with effective drug treatment, up to 70% of individuals with active epilepsy have the potential to become seizure-free and go into long-term remission shortly after starting drug therapy, the majority of which may be able to achieve remission with a single antiepileptic drug (AED).The correct choice of first-line antiepileptic therapy for individuals with newly diagnosed seizures is of great importance. Read More

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http://dx.doi.org/10.1002/14651858.CD012065.pub2DOI Listing
December 2016
17 Reads

Endoscopic Excision of Symptomatic Simple Bone Cyst at Skull Base.

J Clin Diagn Res 2016 Oct 1;10(10):PD03-PD04. Epub 2016 Oct 1.

Consultant ENT Surgeon, Department of ENT, Bombay Hospital Institute of Medical Sciences , Mumbai, Maharashtra, India .

Seizure is a classical feature of intra axial brain parenchymal lesion. Simple bone cyst is an unusual bony pathology at skull base presenting with unexpected symptoms of complex partial seizures. Skull base neuro-endoscopy has managed such lesions more effectively with reduced post-operative morbidity as compared to transcranial approach. Read More

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http://dx.doi.org/10.7860/JCDR/2016/20684.8646DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5121734PMC
October 2016
5 Reads