114,761 results match your criteria Seizures Simple Partial


Prescription Medication Misuse.

Semin Neurol 2018 Dec 6;38(6):654-664. Epub 2018 Dec 6.

Clinical Addiction Research and Education Unit, Section of General Internal Medicine, Boston University School of Medicine, Boston Medical Center, Boston, MA.

In the United States, there is a prescription medication misuse crisis including increases in unintentional drug overdose deaths, medications obtained on the illicit market (i.e., diversion), and in the number of individuals seeking treatment for addiction to prescription medications. Read More

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December 2018
3 Reads

Metabolome-wide association study of anti-epileptic drug treatment during pregnancy.

Toxicol Appl Pharmacol 2018 Dec 3. Epub 2018 Dec 3.

Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, United States. Electronic address:

Pregnant women with epilepsy (PWWE) require continuous anti-epileptic drug (AED) treatment to avoid risk to themselves and fetal risks secondary to maternal seizures, resulting in prolonged AED exposure to the developing embryo and fetus. The objectives of this study were to determine whether high-resolution metabolomics is able to link the metabolite profile of PWWE receiving lamotrigine or levetiracetam for seizure control to associated pharmacodynamic (PD) biological responses. Untargeted metabolomic analysis of plasma obtained from 82 PWWE was completed using high-resolution mass spectrometry. Read More

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December 2018
4 Reads

An update of cyclooxygenase (COX)-inhibitors in epilepsy disorders.

Authors:
Ashish Dhir

Expert Opin Investig Drugs 2018 Dec 6. Epub 2018 Dec 6.

a Department of Neurology , School of Medicine, University of California Davis , Sacramento , CA , USA.

Introduction: Neuroinflammation has a critical role in brain disorders. Cyclooxygenase (COX) is one of the principal drug targets for the reduction of neuroinflammation; however, studies have yielded mixed results for COX-inhibitors in the treatment of diverse acute and chronic models of epilepsy. Areas covered: The article covers the effects of COX-inhibitors in epilepsy disorders. Read More

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December 2018
1 Read

Tranexamic Acid and Seizures in Pediatric Trauma.

Pediatr Crit Care Med 2018 Dec;19(12):1177-1178

Department of Pediatrics, Sections of Pediatric Critical Care and Pediatric Hematology, Oncology and Bone Marrow Transplantation, University of Colorado School of Medicine, Aurora, CO Division of Pediatric Surgery, Department of Surgery, University of Colorado School of Medicine, Aurora, CO Section of Pediatric Critical Care, Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO.

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December 2018
1 Read

Simultaneous quantification of thirteen cannabinoids and metabolites in human plasma by liquid chromatography tandem mass spectrometry in adult epilepsy patients.

Ther Drug Monit 2018 Dec 4. Epub 2018 Dec 4.

Department of Experimental and Clinical Pharmacology and.

Background: A sensitive, robust method was developed and validated to quantitate thirteen major natural cannabinoid parent and metabolite compounds in human plasma at or below 0.5 ng/mL.

Methods: A liquid chromatography-tandem mass spectrometry method was developed and validated to measure thirteen cannabinoid compounds: cannabidiol (CBD), cannabidiolic acid (CBDA), cannabidivarin (CBDV), cannabinol (CBN), cannabigerol (CBG), cannabigerolic acid (CBGA), cannabichromene (CBC), Δ-tetrahydocannabinol (THC), Δ-tetrahydrocannabinolic acid A (THCA), Δ-tetrahydrocannabivarin (THCV), 11-hydroxy-Δ-tetrahydrocannbinol (11-OH-THC), 11-nor-9-carboxy-Δ-tetrahydrocannbinol (THC-COOH), and 11-nor-9-carboxy-Δ-tetrahydrocannabinol-glucuronide (THC-COOH-glu). Read More

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December 2018
1 Read

Prediction error connectivity: A new method for EEG state analysis.

Neuroimage 2018 Nov 30. Epub 2018 Nov 30.

Epilepsy Unit - Neurology Dept. Hospital del Mar - Parc de Salut Mar, Barcelona, Spain; IMIM - Hospital del Mar Medical Research Institute, Barcelona, Spain.

Several models have been proposed to explain brain regional and interregional communication, the majority of them using methods that tap the frequency domain, like spectral coherence. Considering brain interareal communication as binary interactions, we describe a novel method devised to predict dynamics and thus highlight abrupt changes marked by unpredictability. Based on a variable-order Markov model algorithm developed in-house for data compression, the prediction error connectivity (PEC) estimates network transitions by calculating error matrices (EMs). Read More

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November 2018

Association of Seizure Spread With Surgical Failure in Epilepsy.

JAMA Neurol 2018 Dec 3. Epub 2018 Dec 3.

Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut.

Importance: Seizures recur in as many as half of patients who undergo surgery for drug-resistant temporal lobe epilepsy (TLE). Understanding why TLE is resistant to surgery in some patients may reveal insights into epileptogenic networks and direct new therapies to improve outcomes.

Objective: To characterize features of surgically refractory TLE. Read More

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December 2018

RNA-sequencing analysis of umbilical cord plasma microRNAs from healthy newborns.

PLoS One 2018 3;13(12):e0207952. Epub 2018 Dec 3.

FutureNeuro Research Centre, Royal College of Surgeons in Ireland, Dublin, Ireland.

MicroRNAs are a class of small non-coding RNA that regulate gene expression at a post-transcriptional level. MicroRNAs have been identified in various body fluids under normal conditions and their stability as well as their dysregulation in disease has led to ongoing interest in their diagnostic and prognostic potential. Circulating microRNAs may be valuable predictors of early-life complications such as birth asphyxia or neonatal seizures but there are relatively few data on microRNA content in plasma from healthy babies. Read More

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December 2018
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Chemogenetic silencing of hippocampal neurons suppresses epileptic neural circuits.

J Clin Invest 2018 Dec 3. Epub 2018 Dec 3.

Department of Neurosciences, Cleveland Clinic, Cleveland, Ohio, USA.

We investigated how pathological changes in newborn hippocampal dentate granule cells (DGCs) lead to epilepsy. Using a rabies virus-mediated retrograde tracing system and a designer receptors exclusively activated by designer drugs (DREADD) chemogenetic method, we demonstrated that newborn hippocampal DGCs are required for the formation of epileptic neural circuits and the induction of spontaneous recurrent seizures (SRS). A rabies virus-mediated mapping study revealed that aberrant circuit integration of hippocampal newborn DGCs formed excessive de novo excitatory connections as well as recurrent excitatory loops, allowing the hippocampus to produce, amplify, and propagate excessive recurrent excitatory signals. Read More

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December 2018
2 Reads

Co-existence of Rolandic and 3 Hz Spike-Wave Discharges on EEG in Children with Epilepsy.

Can J Neurol Sci 2018 Dec 3:1-7. Epub 2018 Dec 3.

1Department of Pediatrics, Division of Neurology,BC Children's Hospital,Vancouver, British Columbia,Canada.

Objective: Benign epilepsy of childhood with central temporal spikes (BECTS) and absence epilepsy are common epilepsy syndromes in children with similar age of onset and favorable prognosis. However, the co-existence of the electrocardiogram (EEG) findings of rolandic spike and 3 Hz generalized spike-wave (GSW) discharges is extremely rare, with few cases reported in the literature. Our objective was to characterize the EEG findings of these syndromes in children in our center and review the electro-clinical features. Read More

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December 2018

Perampanel in patients with brain tumour-related epilepsy in real-life clinical practice: a retrospective analysis.

Int J Neurosci 2018 Dec 3:1-10. Epub 2018 Dec 3.

e Biostatistic Unit, Regina Elena National Cancer Institute , Rome , Italy.

Introduction: Epilepsy occurs in 35-70% of patients with gliomas; glutamate plays a central role via AMPA-receptor activation, which is involved both in seizure activity and tumor growth. We conducted a retrospective study on brain tumour-related epilepsy patients (BTRE) treated with perampanel in add-on (PER) for 12 months, to evaluate efficacy and tollerability, according to real-life clinical practice.

Materials And Methods: Medical records of eleven patients (9 males, mean age 54 years) with glioma and epilepsy treated with PER in add-on, for inadequate seizure control or adverse events (AEs) from previous antiepileptic drugs (AEDs) therapy, were reviewed. Read More

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December 2018

The mTOR pathway in treatment of epilepsy: a clinical update.

Future Neurol 2018 May 29;13(2):49-58. Epub 2018 May 29.

Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.

Nearly a third of patients with epilepsy have seizures refractory to current medical therapies. In the search for novel drug targets, the mTOR pathway has emerged as key in the regulation of neuronal function, growth and survival, and other cellular processes related to epileptogenesis. Hyperactivation of the mTOR pathway has been implicated in tuberous sclerosis complex and other 'mTORopathies', clinical syndromes associated with cortical developmental malformations and drug-resistant epilepsy. Read More

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A Case of Seizure Revealing Fahr's Syndrome with Primary Hypoparathyroidism.

Am J Case Rep 2018 Dec 1;19:1430-1433. Epub 2018 Dec 1.

Department of Internal Medicine, Haeundae Paik Hospital, Inje University College of Medicine, Busan, South Korea.

BACKGROUND Idiopathic basal ganglia calcification, also known as Fahr's disease or Fahr's syndrome, is a rare neurological disorder characterized by abnormal calcified deposits in the basal ganglia. Here, we report a case of Fahr's syndrome with calcification of the basal ganglia due to hypoparathyroidism in a patient with seizures. CASE REPORT A 52-year-old male patient visited our clinic with seizures. Read More

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December 2018

Early post-stroke seizures: An unresolved question.

Neurol India 2018 Nov-Dec;66(6):1854-1855

Department of Clinical Neurosciences, University of Calgary, Alberta, Canada.

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December 2018

Neurotoxicity of the antibiotics: A comprehensive study.

Neurol India 2018 Nov-Dec;66(6):1732-1740

Department of Neurosurgery, Tabriz University of Medical Sciences, Tabriz, Iran.

Antibiotics are among the most widely used medications in clinical settings. Seizures, encephalopathy, optic neuropathy, peripheral neuropathy, and exacerbation of myasthenia gravis are important examples of neurotoxic adverse events associated with the use of antibiotics. This article aims to review the most common and important neurotoxic adverse effects associated with various antibiotics routinely used in a clinical setting. Read More

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December 2018

Epilepsy surgery for focal cortical dysplasia: Seizure and quality of life (QOLIE-89) outcomes.

Neurol India 2018 Nov-Dec;66(6):1655-1666

Department of Neurology, National Institute of Mental Health and Neuro-Sciences, Bangalore, Karnataka, India.

Aim: Surgery for drug resistant epilepsy (DRE) with focal cortical dysplasia (FCD) often requires multiple non-invasive as well as invasive pre-surgical evaluations and innovative surgical strategies. There is limited data regarding surgical management of people with FCD as the underlying substrate for DRE among the low and middle-income countries (LAMIC) including India.

Methodology: The presurgical evaluation, surgical strategy and outcome of 52 people who underwent resective surgery for DRE with FCD between January 2008 and December 2016 were analyzed. Read More

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December 2018

Modulator-gated, SUMOylation-mediated, activity-dependent regulation of ionic current densities contributes to short-term activity homeostasis.

J Neurosci 2018 Nov 30. Epub 2018 Nov 30.

Department of Biology, Georgia State University, Atlanta, GA, USA.

Neurons operate within defined activity limits, and feedback control mechanisms dynamically tune ionic currents to maintain this optimal range. This study describes a novel, rapid feedback mechanism that uses SUMOylation to continuously adjust ionic current densities according to changes in activity. mall biquitin-like difier (SUMO) is a peptide that can be post-translationally conjugated to ion channels to influence their surface expression and biophysical properties. Read More

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November 2018

[Progressive myoclonic epilepsy secondary to Lafora's body disease].

Medicina (B Aires) 2018 ;78(6):436-439

Sección Epilepsia, Servicio de Neurología, Hospital Italiano Buenos Aires, Argentina. E-mail:

Lafora's disease is infrequent. However, it is one of the most common causes of progressive myoclonus epilepsy. We present the case of a 19-year-old woman, without comorbidities and normal development that started at 8 years with seizures and that from 15 years, had progressive cognitive deterioration. Read More

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January 2018

Dural arteriovenous fistula mimicking temporal arteritis.

Clin Neurol Neurosurg 2018 Nov 26;176:44-46. Epub 2018 Nov 26.

Department of Neurosurgery, Kuala Lumpur Hospital, Malaysia.

Introduction: Dural arteriovenous fistula (dAVF) is a very rare disease characterized by an abnormal vascular communication between arteries and veins in dural mater. It frequently presents with intracranial haemorrhage. Common presenting symptoms are headache and seizures. Read More

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November 2018

Arbutin attenuates cognitive impairment and inflammatory response in pentylenetetrazol-induced kindling model of epilepsy.

Neuropharmacology 2018 Nov 29;146:117-127. Epub 2018 Nov 29.

Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran; Department of Medical Microbiology, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran.

Arbutin as a natural soluble glycosylated phenol possesses a wide range of pharmacological activities including anti-inflammatory and anti-oxidant effects. The present study was designed to evaluate the effect of arbutin supplementation on seizures behavior, memory performance, glial activation, release of inflammatory factors and neuroprotection in pentylenetetrazole-induced kindling model. Chemical kindling was induced by repetitive injections of PTZ at subconvulsive doses (36 mg/kg). Read More

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November 2018

Pathogenic Variants in Fucokinase Cause a Congenital Disorder of Glycosylation.

Am J Hum Genet 2018 Nov 21. Epub 2018 Nov 21.

Human Genetics Program, Sanford-Burnham-Prebys Medical Discovery Institute, La Jolla, CA 92037, USA. Electronic address:

FUK encodes fucokinase, the only enzyme capable of converting L-fucose to fucose-1-phosphate, which will ultimately be used for synthesizing GDP-fucose, the donor substrate for all fucosyltransferases. Although it is essential for fucose salvage, this pathway is thought to make only a minor contribution to the total amount of GDP-fucose. A second pathway, the major de novo pathway, involves conversion of GDP-mannose to GDP-fucose. Read More

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November 2018

Invasive evaluation in children (SEEG vs subdural grids).

Seizure 2018 Nov 16. Epub 2018 Nov 16.

Service de neurochirurgie pédiatrique, Fondation Rothschild 25-29, rue Manin Paris Cedex 19, France.

Designed from the 60s to the 80s for adults, and despite the development of many new techniques, invasive explorations still have indications in children with focal drug-resistant epilepsy. The main types are stereoelectroencephalography (SEEG) and subdural explorations (SDE). They provide precise information on the localization of the epileptogenic zone (EZ), its relationships with eloquent cortex, and the feasibility of performing a tailored surgical resection. Read More

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November 2018
4 Reads

Tumour-to-Tumour Metastasis Phenomenon: Metastatic Prostatic Adenocarcinoma within an Anaplastic Oligodendroglioma in the Brain of a Dog.

J Comp Pathol 2018 Nov 29;165:62-66. Epub 2018 Oct 29.

Department of Animal Medicine and Surgery, Veterinary Faculty, Cerdanyola del Vallès, Spain; Networking Research Centre on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Spain.

A 10-year-old entire male French bulldog was presented following clusters of generalized tonic-clonic epileptic seizures. Neurolocalization was consistent with a lesion in the left forebrain. Magnetic resonance imaging of the brain revealed a large, ill-defined, intra-axial, space-occupying lesion at the level of the left temporal and parietal lobes, causing marked compression of the adjacent parenchyma. Read More

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November 2018

Multilobar resections for 3t mri-negative epilepsy: worth the trouble?

World Neurosurg 2018 Nov 28. Epub 2018 Nov 28.

Epilepsy Center, Department of Neurosurgery, Medical Center - University of Freiburg, Germany; Department OF Neuropediatrics, University Children's Hospital Zurich, Switzerland. Electronic address:

Objective: Multilobar resections for MRI-negative drug-resistant epilepsy warrant attention since they account for up to one-third of MRI-negative epilepsy surgery. Despite their high relevance, data is sparse, and the risk-benefit ratio is yet under debate. This study aimed to investigate the postsurgical seizure outcomes in this particularly challenging subgroup. Read More

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November 2018

Schizencephaly: A Review of 734 Patients.

Pediatr Neurol 2018 Oct 8;87:23-29. Epub 2018 Aug 8.

Pediatric Oncology Institute/GRAACC, Department of Pediatrics, Universidade Federal de São Paulo, São Paulo, Brazil.

Background: Schizencephaly is a rare congenital cerebral malformation associated with serious neurological manifestations. The number of studies regarding schizencephaly is limited.

Methods: We conducted a literature review and extracted data from the case reports. Read More

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October 2018

Epidemiology of onchocerciasis-associated epilepsy in the Mbam and Sanaga river valleys of Cameroon: impact of more than 13 years of ivermectin.

Infect Dis Poverty 2018 Dec 3;7(1):114. Epub 2018 Dec 3.

Neurology Department, Yaoundé Central Hospital, Yaoundé, Cameroon.

Background: A high epilepsy prevalence has been reported in several onchocerciasis-endemic villages along the Mbam and Sanaga river valleys in Cameroon, including Bilomo and Kelleng. We sought to determine the prevalence of epilepsy in these two villages following more than 13 years of community-directed treatment with ivermectin (CDTI).

Methods: Door-to-door surveys were performed on the entire resident population in the villages in August 2017 and January 2018. Read More

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December 2018

Neurologic conditions and disorders of uremic syndrome of chronic kidney disease: Presentations, causes and treatment strategies.

Authors:
Sherifa A Hamed

Expert Rev Clin Pharmacol 2018 Dec 2. Epub 2018 Dec 2.

a Department of Neurology and Psychiatry , Assiut University Hospital , Assiut , Egypt.

Introduction: Uremic syndrome of chronic kidney disease (CKD) is a term used to describe clinical, metabolic and hormonal abnormalities associated with progressive kidney failure. It is a rapidly growing public health problem worldwide. Nervous system complications occur in every patient with uremic syndrome of CKD. Read More

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December 2018

UBTF Mutation Causes Complex Phenotype of Neurodegeneration and Severe Epilepsy in Childhood.

Neuropediatrics 2018 Dec 5. Epub 2018 Dec 5.

DNA Laboratory, Department of Pediatric Neurology, 2nd Faculty of Medicine, Charles University in Prague and University Hospital Motol, Prague, Czech Republic.

Introduction:  Neurodegenerative diseases of childhood present with progressive decline in cognitive, social, and motor function and are frequently associated with seizures in different stages of the disease. Here we report a patient with severe progressive neurodegeneration with drug-resistant epilepsy of unknown etiology from the age of 2 years.

Methods And Results:  Using whole exome sequencing, we found heterozygous missense de novo variant c. Read More

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December 2018
6 Reads

Psychogenic nonepileptic seizures in children and adolescents: An international cross-cultural study.

Epilepsy Behav 2018 Dec 2;90:90-92. Epub 2018 Dec 2.

Children's Comprehensive Epilepsy Center, Alberta Children's Hospital, Calgary, Canada; Alberta Children's Hospital Research Institute, Calgary, Canada; Cumming School of Medicine, University of Calgary, Alberta, Canada. Electronic address:

Purpose: We compared various clinical characteristics of psychogenic nonepileptic seizures (PNES) between young patients from Iran, Saudi Arabia, and Canada, three nations with significantly different socioeconomic and demographic characteristics. This international cross-cultural comparative study may advance our knowledge and understanding of PNES in children and adolescents across the cultures and borders.

Methods: In this retrospective study, we investigated all patients 16 years of age or younger, with PNES admitted to the epilepsy monitoring units at one center in Iran, one center in Saudi Arabia, and one center in Canada. Read More

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December 2018
1 Read

SGPL1 Deficiency: A Rare Cause of Primary Adrenal Insufficiency.

J Clin Endocrinol Metab 2018 Dec 3. Epub 2018 Dec 3.

Section on Endocrinology and Genetics, Program on Developmental Endocrinology and Genetics & Pediatric Endocrinology Inter-Institute Training Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.

Context: Multiple autosomal recessive genes have been etiologically linked to Primary Adrenal Insufficiency (PAI). Recently, SGPL1 gene mutations were recognized as causes of steroid-resistant nephrotic syndrome type 14 (NPHS14), a sphingolipidosis with multisystemic manifestations including PAI. Interestingly, this is the only monogenetic form of nephrotic syndrome (NS) and the sole sphingolipidosis causing adrenal disease. Read More

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December 2018
5 Reads

Altered A-Type Potassium Channel Function in the Nucleus Tractus Solitarius in Acquired Temporal Lobe Epilepsy.

J Neurophysiol 2018 Dec 5. Epub 2018 Dec 5.

Neuroscience, University of Kentucky College of Medicine, United States.

Sudden unexpected death in epilepsy (SUDEP) is among the leading causes of death in people with epilepsy. Individuals with temporal lobe epilepsy (TLE) have a high risk for SUDEP because the seizures are often medically intractable. Neurons in the nucleus tractus solitarius (NTS) have been implicated in mouse models of SUDEP and play a critical role in modulating cardiorespiratory and autonomic output. Read More

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December 2018
1 Read

The highly efficient power house in the Wistar Audiogenic Rat (WAR), an epileptic rat strain.

Am J Physiol Regul Integr Comp Physiol 2018 Dec 5. Epub 2018 Dec 5.

Departamento de Física e Química, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo (USP), Brazil.

The Wistar Audiogenic Rat (WAR) is an animal model of tonic-clonic epileptic seizures, developed after genetic selection by sister x brother inbreeding of Wistar rats susceptible to sound stimuli. Although metabolic changes have been described in this strain, nothing, however, is known about its mitochondrial metabolism. Here, we addressed mitochondrial aspects of OXPHOS, oxidative stress, biogenesis and dynamics in liver, skeletal muscle and heart of male WAR, correlating then to physiological aspects of body metabolism. Read More

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December 2018
1 Read

Tranexamic Acid Is Efficacious at Decreasing the Rate of Blood Loss in Adolescent Scoliosis Surgery: A Randomized Placebo-Controlled Trial.

J Bone Joint Surg Am 2018 Dec;100(23):2024-2032

Department of Anesthesiology, Critical Care, and Pain Medicine (S.M.G., D.Z., M.E.M., R.M.B., and N.F.S.) and Department of Orthopaedic Surgery (M.P.G., D.H., L.I.K., J.B.E., and M.T.H.), Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts.

Background: Tranexamic acid (TXA) is an antifibrinolytic drug that reduces surgical blood loss. Evidence supporting its efficacy in surgery for adolescent idiopathic scoliosis is not robust. This trial was designed to validate the clinical efficacy of TXA in surgery for adolescent idiopathic scoliosis. Read More

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December 2018
1 Read

Management of Comatose Survivors of Cardiac Arrest.

Authors:
David B Seder

Continuum (Minneap Minn) 2018 Dec;24(6):1732-1752

Purpose Of Review: Because the whole-body ischemia-reperfusion insult associated with cardiac arrest often results in brain injury, neurologists perform an important role in postresuscitation cardiac arrest care. This article provides guidance for the assessment and management of brain injury following cardiac arrest.

Recent Findings: Neurologists have many roles in postresuscitation cardiac arrest care: (1) early assessment of brain injury severity to help inform triage for invasive circulatory support or revascularization; (2) advocacy for the maintenance of a neuroprotective thermal, hemodynamic, biochemical, and metabolic milieu; (3) detection and management of seizures; (4) development of an accurate, multimodal, and conservative approach to prognostication; (5) application of shared decision-making paradigms around the likely outcomes of therapy and the goals of care; and (6) facilitation of the neurocognitive assessment of survivors. Read More

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December 2018
2 Reads

Cannabis-based products for pediatric epilepsy: A systematic review.

Epilepsia 2018 Dec 4. Epub 2018 Dec 4.

School of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario, Canada.

Objective: To assess the benefits and harms of cannabis-based products for pediatric epilepsy.

Methods: We identified in this living systematic review randomized controlled trials (RCTs) and nonrandomized studies (NRSs) involving children with epilepsy treated with cannabis-based products. We searched MEDLINE, Embase, PsycINFO, Cochrane Library, and gray literature (April 25, 2018). Read More

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December 2018
2 Reads

The Role of Oxidative Stress and Bioenergetic Dysfunction in Sulfite Oxidase Deficiency: Insights from Animal Models.

Neurotox Res 2018 Dec 5. Epub 2018 Dec 5.

Programa de Pós-Graduação em Ciências Biológicas: Bioquímica, Departamento de Bioquímica, ICBS, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2600-Anexo, Porto Alegre, RS, 90035-003, Brazil.

Sulfite oxidase (SO) deficiency is an autosomal recessive inherited neurometabolic disease caused by deficient activity of SO. It is biochemically characterized by tissue accumulation and high urinary excretion of sulfite, thiosulfate, and S-sulfocysteine. Severe neurological symptoms, including neonatal seizures, encephalopathy, and psychomotor retardation, are commonly observed in the affected patients, but the pathogenesis of the neurologic dysfunction is still poorly understood. Read More

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December 2018

Thrombin and the Protease-Activated Receptor-1 in Organophosphate-Induced Status Epilepticus.

J Mol Neurosci 2018 Dec 4. Epub 2018 Dec 4.

Department of Neurology, The Chaim Sheba Medical Center, Tel HaShomer, 52621, Ramat Gan, Israel.

Organophosphates (OP) are a major threat to the health of soldiers and civilians due to their use as chemical weapons in war and in terror attacks. Among the acute manifestations of OP poisoning, status epilepticus (SE) is bearing the highest potential for long-term damages. Current therapies do not prevent brain damage and seizure-related brain injuries in OP-exposed humans. Read More

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December 2018
1 Read

ANO10 mutational screening in recessive ataxia: genetic findings and refinement of the clinical phenotype.

J Neurol 2018 Dec 4. Epub 2018 Dec 4.

Unit of Medical Genetics and Neurogenetics, Fondazione IRCCS Istituto Neurologico Carlo Besta, via Celoria 11, 20133, Milan, Italy.

Autosomal recessive cerebellar ataxia type 3 (ARCA3) is a rare inherited disorder caused by mutations in the ANO10 gene. The disease is characterized by slowly progressive spastic ataxia variably associated with motor neuron involvement, epilepsy, and cognitive decline. We performed mutational screening in 80 patients with sporadic or autosomal recessive adult-onset ataxia. Read More

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December 2018
1 Read

mTOR Inhibitors as a New Therapeutic Strategy in Treatment Resistant Epilepsy in Hemimegalencephaly: A Case Report.

J Child Neurol 2018 Dec 5:883073818813238. Epub 2018 Dec 5.

1 Division of Neurology, University of British Columbia, BC Children's Hospital, Vancouver, BC, Canada.

Hemimegalencephaly is a hamartomatous malformation of one hemisphere. Functional hemispherectomy, the definitive treatment, is associated with significant morbidity and mortality in early infancy. Dysregulation of the mTOR pathway can result in malformations of cortical development, and mTOR inhibitors can effectively reduce seizures in tuberous sclerosis complex. Read More

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December 2018

Temporally linked occurrences of epileptic and psychogenic nonepileptic seizures - Coincidental or pathogenically related?

Seizure 2018 Nov 28;64:20-22. Epub 2018 Nov 28.

Peter Kellaway Section of Neurophysiology, Department of Neurology, Baylor College of Medicine, Houston, Texas, USA; Neurology Care Line, Michael E. DeBakey Veterans Affairs Medical Center, Houston, Texas, USA. Electronic address:

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November 2018

Inhibitory effects of chronic administration of vitamin D on pentylenetetrazole-induced seizures in mice.

Epilepsy Res 2018 Nov 28;149:76-82. Epub 2018 Nov 28.

Physiology Research Center, Kashan University of Medical Sciences, Kashan, Iran; Department of Pharmacology, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran. Electronic address:

Vitamin D as a neuroactive steroid hormone plays an important role in the nervous system. Recent clinical and experimental studies have shown an association between vitamin D-related disorders and epilepsy. Therefore, this study was designed to examine the effects of chronic administration of vitamin D on pentylenetetrazole (PTZ)-induced seizure in mice. Read More

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November 2018
1 Read

Clinical presentations of onchocerciasis-associated epilepsy (OAE) in Cameroon.

Epilepsy Behav 2018 Dec 1;90:70-78. Epub 2018 Dec 1.

Neurology Department, Yaoundé Central Hospital, Cameroon; Faculty of Medicine and Biomedical Sciences, The University of Yaoundé I, Cameroon; Brain Research Africa Initiative (BRAIN), Yaoundé, Cameroon. Electronic address:

Background: A high prevalence of epilepsy has been observed in several onchocerciasis-endemic countries, including Cameroon. However, little is known on the clinical presentations of the affected persons with epilepsy (PWE). A community-based study was conducted with the aim of describing the spectrum of seizures in selected onchocerciasis-endemic villages in Cameroon and documenting relevant medical history in patients with onchocerciasis-associated epilepsy (OAE). Read More

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December 2018
3 Reads

Micturition and startle-induced reflex seizures in a patient with focal cortical dysplasia in the middle frontal gyrus.

Clin Neurophysiol 2018 Nov 26;130(1):109-110. Epub 2018 Nov 26.

University Clinic of Neurology, Medical Faculty, Ss. Cyril and Methodius University, Vodnjanska Str. 17, MK-1000 Skopje, The Former Yugoslav Republic of Macedonia.

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November 2018
4 Reads

Genotype Differences in Sensitivity to the Anticonvulsant Effect of the Synthetic Neurosteroid Ganaxolone During Chronic Ethanol Withdrawal.

Neuroscience 2018 Dec 1. Epub 2018 Dec 1.

Department of Behavioral Neuroscience, Oregon Health & Science University, Portland OR 97239, United States; Portland Alcohol Research Center, VA Portland Health Care System, Portland, OR 97239, United States.

Sensitivity to anticonvulsant effects of the γ-aminobutyric acid receptor-active neurosteroid allopregnanolone (ALLO) during ethanol withdrawal varies across genotypes, with high sensitivity in genotypes with mild withdrawal and low sensitivity in genotypes with high withdrawal. The present studies determined whether the resistance to ALLO during withdrawal in mouse genotypes with high handling-induced convulsions (HICs) during withdrawal could be overcome with use of ganaxolone (GAN), the metabolically stable derivative of ALLO. In separate studies, male and female Withdrawal Seizure-Prone (WSP-1) and DBA/2J (D2) mice were exposed to air (controls) or 72 hour ethanol vapor and then were scored for HICs during withdrawal (hourly for the first 12 hours, then at hours 24 and 25). Read More

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December 2018
1 Read

Autoimmune encephalitis with psychosis: Warning signs, step-by-step diagnostics and treatment.

World J Biol Psychiatry 2018 Dec 4:1-25. Epub 2018 Dec 4.

e Department of Psychiatry and Psychotherapy , Ludwig-Maximilians-University Munich , Munich , Germany.

Objectives: Despite intensive research, schizophrenia and schizoaffective disorders continue to be theoretical constructs that describe clinical syndromes and no pathophysiologically defined diseases. Moreover, there are no clear biomarkers at hand. Therefore, these diagnoses are still set up based on clinical ICD-10 / DSM-5 criteria and the exclusion of alcohol- / drug-associated, systemic or other brain organic causes. Read More

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December 2018
1 Read

Dog alerting and/or responding to epileptic seizures: A scoping review.

PLoS One 2018 4;13(12):e0208280. Epub 2018 Dec 4.

Université de Rennes, Normandie Univ, CNRS, EthoS (Éthologie animale et humaine)-UMR 6552, Paimpont, France.

Recently, there has been a rising interest in service dogs for people with epilepsy. Dogs have been reported as being sensitive to epileptic episodes in their owners, alerting before and/or responding during or after a seizure, with or without specific training. The purpose of this review is to present a comprehensive overview of the scientific research on seizure-alert/response dogs for people with epilepsy. Read More

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December 2018
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Efficacy of rufinamide in childhood refractory epilepsy.

Turk J Pediatr 2018 ;60(3):238-243

Departments of Pediatric Neurology, Istanbul University Istanbul Faculty of Medicine, İstanbul, Turkey.

Yıldız EP, Hızlı Z, Bektaş G, Ulak-Özkan M, Tatlı B, Aydınlı N, Çalışkan M, Özmen M. Efficacy of rufinamide in childhood refractory epilepsy. Turk J Pediatr 2018; 60: 238-243. Read More

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January 2018