1,003 results match your criteria Seizures Simple Partial


Mechanical Thrombectomy for cerebral venous sinus thrombosis: A Case series & Technical Note.

World Neurosurg 2020 May 7. Epub 2020 May 7.

Division of Neuroradiology, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada; Division of Neurosurgery, Department of Surgery, Toronto Western Hospital, Toronto.

Background: Cerebral venous sinus thrombosis is a rare cause of acute stroke. It may lead to hemorrhagic venous infarctions, brain swelling or raised intracranial pressure and it can be associated with significant mortality and morbidity. Low molecular weight heparin is the mainstay of treatment. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.04.220DOI Listing
May 2020
2.417 Impact Factor

Efficacy and safety of eslicarbazepine acetate as adjunctive therapy for refractory focal-onset seizures in children: A double-blind, randomized, placebo-controlled, parallel-group, multicenter, phase-III clinical trial.

Epilepsy Behav 2020 Apr 6;105:106962. Epub 2020 Mar 6.

BIAL - Portela & Cª. S.A., S. Mamede do Coronado, Portugal; Department of Biomedicine, Pharmacology and Therapeutics Unit, Faculty of Medicine, University Porto, Porto, Portugal; MedInUP - Center for Drug Discovery and Innovative Medicines, University Porto, Porto, Portugal. Electronic address:

Purpose: This was a phase-III, randomized, double-blind, placebo-controlled study aimed to evaluate efficacy and tolerability of eslicarbazepine acetate (ESL) as adjunctive therapy in pediatric patients with refractory focal-onset seizures (FOS).

Methods: Children (2-18 years old) with FOS, receiving 1-2 antiepileptic drugs, were randomized to ESL or placebo. Treatment was started at 10 mg/kg/day, up-titrated up to 20-30 mg/kg/day, and maintained for 12 weeks, followed by one-year open-label follow-up. Read More

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http://dx.doi.org/10.1016/j.yebeh.2020.106962DOI Listing

EEG based multi-class seizure type classification using convolutional neural network and transfer learning.

Neural Netw 2020 Apr 25;124:202-212. Epub 2020 Jan 25.

Department of Neurosurgery, Maastricht University Medical Center, Maastricht, The Netherlands.

Recognition of epileptic seizure type is essential for the neurosurgeon to understand the cortical connectivity of the brain. Though automated early recognition of seizures from normal electroencephalogram (EEG) was existing, no attempts have been made towards the classification of variants of seizures. Therefore, this study attempts to classify seven variants of seizures with non-seizure EEG through the application of convolutional neural networks (CNN) and transfer learning by making use of the Temple University Hospital EEG corpus. Read More

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http://dx.doi.org/10.1016/j.neunet.2020.01.017DOI Listing

A convolutional neural network based framework for classification of seizure types.

Conf Proc IEEE Eng Med Biol Soc 2019 07;2019:2547-2550

Epileptic seizures are caused by a disturbance in the electrical activity of the brain and classified as many different types of epileptic seizures based on the characteristics of EEG and other parameters. Till now research has been conducted to classify EEG as seizure and non-seizures, but the classification of seizure types has not been explored. Thus, in this paper, we have proposed the 8-class classification problem in order to classify different seizure types using convolutional neural networks (CNN). Read More

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http://dx.doi.org/10.1109/EMBC.2019.8857359DOI Listing

Development and Validation of an UHPLC-MS/MS Assay for the Therapeutic Monitoring of Brivaracetam Plasma Concentrations in Patients with Epilepsy.

Ther Drug Monit 2020 Jun;42(3):445-451

IRCCS-Istituto delle Scienze Neurologiche di Bologna.

Background: Brivaracetam is an antiepileptic drug used as an add-on therapy for partial-onset seizures in subjects aged 4 years and older. Owing to potential drug interactions and intersubject variability in plasma concentrations, therapeutic monitoring for brivaracetam may be useful. The aim of this study was to develop a simplified method for measuring brivaracetam plasma concentrations applicable to therapeutic drug monitoring in epilepsy. Read More

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http://dx.doi.org/10.1097/FTD.0000000000000726DOI Listing

Trazodone increases seizures in a genetic WAG/Rij rat model of absence epilepsy while decreasing them in penicillin-evoked focal seizure model.

Authors:
Hatice Aygun

Epilepsy Behav 2020 Feb 18;103(Pt A):106847. Epub 2019 Dec 18.

Department of Physiology, Faculty of Medicine, Tokat Gaziosmanpasa University, Tokat, Turkey. Electronic address:

Aim: Psychiatric disorders, especially depression and anxiety, are among the most disabling comorbidities in patients with epilepsy, and they are difficult to treat because many antidepressants cause proconvulsive effects. Thus, it is important to identify the seizure risks associated with antidepressants. Trazodone is one of the most frequently prescribed selective serotonin reuptake inhibitor (SSRI) antidepressant drugs for the treatment of depression and anxiety. Read More

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http://dx.doi.org/10.1016/j.yebeh.2019.106847DOI Listing
February 2020

Nonketotic Hyperglycemia-related Seizures of Left Parieto-occipital Origin: A Case Report.

J Neurosci Nurs 2020 Feb;52(1):27-29

Yu-Shiue Chen, BS, RN, is Nurse Practitioner, Department of Neurology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan. Tsang-Shan Chen, MD, is Chair, Department of Neurology, Tainan Sin-Lau Hospital, Tainan, Taiwan.

Introduction: Nonketotic hyperglycemia-related seizures are not uncommonly encountered in clinical practice. Their presentation varies, and they may cause serious consequences if they remain unnoticed.

Case: We report a case of nonketotic hyperglycemia-related seizures of unique left parieto-occipital origin and semiology, presenting as focal aware (simple partial) and impaired awareness (complex partial) seizures, including contralateral limb convulsion and apraxialike behavior. Read More

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http://dx.doi.org/10.1097/JNN.0000000000000481DOI Listing
February 2020

Thymoma associated paraneoplastic encephalitis (TAPE), a potential cause of limbic encephalitis.

BMJ Case Rep 2019 Aug 30;12(8). Epub 2019 Aug 30.

Division of Infectious Diseases, California Pacific Medical Center, San Francisco, California, USA.

A 59-year-old man presents with expressive aphasia and short term memory deficits. Shortly thereafter, he started developing staring spells and intermittent right hand spasms, preliminarily thought to be simple partial seizures. Subsequent MRI brain imaging was highly suggestive of herpes simplex virus (HSV) encephalitis; however, HSV PCR from cerebrospinal fluid was negative. Read More

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http://dx.doi.org/10.1136/bcr-2019-230709DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6720759PMC
August 2019
3 Reads

Gross Total Resection of a Grade IV Astrocytoma Adjacent to the Precentral Gyrus With Nonawake Motor Mapping and Motor-Evoked Potential Monitoring: 3-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2020 Apr;18(4):E127-E128

Department of Neurological Surgery, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin.

Surgical treatment of the gliomas located in or adjacent to the eloquent areas poses significant challenge to neurosurgeons. The main goal of the surgery is to achieve maximal safe resection while preserving the neurological function. This might be possible with utilizing pre- and intraoperative adjuncts such as functional magnetic resonance imaging (MRI), image guidance, mapping of the function of interest, intraoperative MRI, and neurophysiological monitoring. Read More

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http://dx.doi.org/10.1093/ons/opz185DOI Listing
April 2020
6 Reads

Electroacupuncture Reduces Seizure Activity and Enhances GAD 67 and Glutamate Transporter Expression in Kainic Acid Induced Status Epilepticus in Infant Rats.

Behav Sci (Basel) 2019 Jun 27;9(7). Epub 2019 Jun 27.

Unidad de Investigación Médica en Enfermedades Neurológicas, Hospital de Especialidades "Dr. Bernardo Sepúlveda", Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social (IMSS), Ciudad de México CP.06720, Mexico.

Status epilepticus (SE) is one of the most significant complications in pediatric neurology. Clinical studies have shown positive effects of electroacupuncture (EA) as a therapeutic alternative in the control of partial seizures and secondary generalized clonic seizures. EA promotes the release of neurotransmitters such as GABA and some opioids. Read More

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http://dx.doi.org/10.3390/bs9070068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6680393PMC
June 2019
7 Reads

Topiramate versus carbamazepine monotherapy for epilepsy: an individual participant data review.

Cochrane Database Syst Rev 2019 06 24;6:CD012065. Epub 2019 Jun 24.

Department of Biostatistics, University of Liverpool, Block F, Waterhouse Building, 1-5 Brownlow Hill, Liverpool, UK, L69 3GL.

Background: This is an updated version of the original Cochrane Review published in Issue 12, 2016. This review is one in a series of Cochrane Reviews investigating pair-wise monotherapy comparisons.Epilepsy is a common neurological condition in which abnormal electrical discharges from the brain cause recurrent unprovoked seizures. Read More

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http://dx.doi.org/10.1002/14651858.CD012065.pub3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590101PMC
June 2019
4 Reads

Treatable cause of hereditary spastic paraplegia: eight cases of combined homocysteinaemia with methylmalonic aciduria.

J Neurol 2019 Oct 15;266(10):2434-2439. Epub 2019 Jun 15.

Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Shuaifuyuan 1, Dongcheng district, Beijing, 100730, China.

Combined homocysteinemia with methylmalonic aciduria (MMA/HCY) are genetic disorders of intracellular cobalamin (cbl) transport and processing that cause downstream deficiencies in methylcobalamin and adenosylcobalamin. Untreated disease is characterized biochemically by methylmalonic aciduria and hyperhomocysteinemia, while the clinical features are variable. When spastic paraplegia (SP) dominates, it is difficult to differentiate from hereditary spastic paraplegia (HSP). Read More

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http://link.springer.com/10.1007/s00415-019-09432-8
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http://dx.doi.org/10.1007/s00415-019-09432-8DOI Listing
October 2019
21 Reads

[Tuberculoma of the right frontal lobe with epileptic seizures].

Zh Nevrol Psikhiatr Im S S Korsakova 2019 ;119(4):60-65

Almazov National Medical Research Center, St.-Petersburg, Russia.

Tuberculosis remains a serious global health issue. Tuberculosis of the central nervous system is the most frequent cause of chronic infection. Presented is a case of a 17 year-old patient with simple partial seizures with secondary generalization and increased intracranial pressure. Read More

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http://dx.doi.org/10.17116/jnevro201911904160DOI Listing
August 2019
15 Reads

Rogue bioelectrical waves in the brain: the Hurst exponent as a potential measure for presurgical mapping in epilepsy.

J Neural Eng 2019 08 21;16(5):056019. Epub 2019 Aug 21.

Aston Brain Centre, Aston University, Birmingham, B4 7ET, United Kingdom.

Objective: Brain electromagnetic activity in patients with epilepsy is characterized by abnormal high-amplitude transient events (spikes) and abnormal patterns of synchronization of brain rhythms that accompany epileptic seizures. With the aim of improving methods for identifying epileptogenic sources in magnetoencephalographic (MEG) recordings of brain data, we applied methods previously used in the study of oceanic 'rogue waves' and other freak events in complex systems.

Approach: For data from three patients who were awaiting surgical treatment for epilepsy, we used a beamformer source model to produce volumetric maps showing areas with a high proportion of spikes that could be classified as 'rogue waves', and areas with high Hurst exponent (HE). Read More

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http://dx.doi.org/10.1088/1741-2552/ab225eDOI Listing
August 2019
6 Reads

EEG-based connectivity in patients with partial seizures with and without generalization.

Ideggyogy Sz 2019 Mar;72(3-4):99-109

University of Debrecen, Medical Center, Department of Neurology, Debrecen.

Background And Purpose: To investigate the neurophysiological basis of secondary generalization of partial epileptic seizures.

Methods: Inter-ictal, resting-state EEG functional connectivity (EEGfC) was evaluated and compared: patients with exclusively simple partial seizures (sp group) were compared to patients with simple partial and secondary generalized seizures (spsg group); patients with exclusively complex partial seizures (cp group) were compared to patients with cp and secondary generalized seizures (cpsg group); the collapsed sp+cp group (spcp) was compared to those who had exclusively secondary generalized seizures (sg group). EEGfC was computed from 21-channel waking EEG. Read More

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http://www.elitmed.hu/kiadvanyaink/ideggyogyaszati-szemle/ke
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http://dx.doi.org/10.18071/isz.72.0099DOI Listing
March 2019
24 Reads

Tonic Seizure as a Different Seizure Type Presented in Autoimmune Epilepsy Caused by Systemic Lupus Erythematosus.

J Nerv Ment Dis 2019 03;207(3):188-191

Department of Neurology, Department of Neurology and Neuroscience Center, The First Hospital of JiLin University, Changchun, People's Republic of China.

The diagnosis of autoimmune epilepsy is often challenging, and may be misdiagnosed as epileptic disorders or viral encephalitis. Autoimmune epilepsy has a strong association with other autoimmune diseases, especially systemic lupus erythematosus (SLE). In addition, autoimmune epilepsy was reported to present with complex partial seizure (CPS), simple partial seizure (SPS), and secondarily generalized tonic-clonic seizure (sGTCS). Read More

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http://dx.doi.org/10.1097/NMD.0000000000000946DOI Listing
March 2019
21 Reads

Health utilities and quality of life in individuals with tuberous sclerosis complex (TSC) who experience epileptic seizures: A web-based survey.

Epilepsy Behav 2019 03 25;92:213-220. Epub 2019 Jan 25.

St George's Hospital, Blackshaw Road, London SW17 0QT, United Kingdom.

Objectives: Individuals with tuberous sclerosis complex (TSC) experience a wide range of health impacts, including epileptic seizures, negatively impacting their health-related quality of life (HRQoL). Health state utility values (HSUVs) are index values representing HRQoL and are used as key inputs for health economic analyses. Such data are currently very limited in the TSC population. Read More

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http://dx.doi.org/10.1016/j.yebeh.2018.11.021DOI Listing
March 2019
12 Reads

Seizures After Stereotactic Radiosurgery for Benign Supratentorial Meningiomas: An Uncontrollable Type of Seizure?

World Neurosurg 2019 Mar 5;123:e549-e556. Epub 2018 Dec 5.

Department of Neurosurgery, Seoul National University Bundang Hospital, Seongnam-si, Republic of Korea; Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Republic of Korea. Electronic address:

Objective: We investigated seizure outcomes of patients with supratentorial meningiomas (ST-MNGs) treated with stereotactic radiosurgery (SRS).

Methods: One hundred and thirty-three patients with a total of 144 ST-MNGs, who were treated with SRS between 2009 and 2016, were included in this study. The mean age was 59. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.11.211DOI Listing
March 2019
6 Reads

Focal Electrographic Seizures in a Patient With Autism Spectrum Disorder and Speech Delay.

J Dev Behav Pediatr 2018 12;39(9):763-765

Boston University School of Medicine, Division of Developmental and Behavioral Pediatrics, Boston Medical Center, Boston, MA.

Case: A 6-year-old boy with a diagnosis of autism spectrum disorder (ASD) presented to primary care for a new-patient, transfer-of-care evaluation. At the initial encounter, the patient used a maximum of 60 words and was receiving speech and language therapy (SLT) through school. Family history was positive for seizures in the father and paternal grandfather as well as ASD in an older brother. Read More

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http://dx.doi.org/10.1097/DBP.0000000000000631DOI Listing
December 2018
20 Reads

Carbamazepine versus phenobarbitone monotherapy for epilepsy: an individual participant data review.

Cochrane Database Syst Rev 2018 10 24;10:CD001904. Epub 2018 Oct 24.

Department of Biostatistics, University of Liverpool, Block F, Waterhouse Building, 1-5 Brownlow Hill, Liverpool, UK, L69 3GL.

Background: This is an updated version of the Cochrane Review previously published in 2016. This review is one in a series of Cochrane Reviews investigating pair-wise monotherapy comparisons.Epilepsy is a common neurological condition in which abnormal electrical discharges from the brain cause recurrent unprovoked seizures. Read More

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http://doi.wiley.com/10.1002/14651858.CD001904.pub4
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http://dx.doi.org/10.1002/14651858.CD001904.pub4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6517155PMC
October 2018
32 Reads

Awake craniotomy without sedation in treatment of patients with lesional epilepsy.

Surg Neurol Int 2018 3;9:177. Epub 2018 Sep 3.

Federal Centre of Treatment and Rehabilitation of Ministry of Healthcare of Russian Federation, 125367 Moscow, Russia.

Background: The use of awake craniotomy for surgical treatment of epilepsy was applied in surgery of convexital tumors, arteriovenous malformations, some superficial aneurysms, and stereotactic neurosurgery. The aim of this study was to show the advantages of awake craniotomy without sedation, accompanied by intraoperative neurophysiological monitoring in patients with symptomatic epilepsy.

Methods: This article describes the results of surgical treatment in 41 patients with various pathologies; 31 among them suffered from epilepsy. Read More

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http://dx.doi.org/10.4103/sni.sni_24_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130149PMC
September 2018
8 Reads

Bilateral stereotactic lesions and chronic stimulation of the anterior thalamic nuclei for treatment of pharmacoresistant epilepsy.

Surg Neurol Int 2018 19;9:137. Epub 2018 Jul 19.

Federal Centre of Treatment and Rehabilitation of Ministry of Healthcare of Russian Federation, Ivankovskoe, Moscow, Russia.

Background: The use of the anterior nucleus of thalamus (ANT) as a target for treatment of pharmacoresistant epilepsy is based on its crucial role in seizure propagation. We describe results of chronic bilateral ANT stimulation and bilateral ANT lesions in 31 patients with refractory epilepsy.

Methods: ANT DBS was performed in 12 patients (group I) and bilateral stereotactic radiofrequency lesions of ANT were performed in 19 patients (group II). Read More

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http://dx.doi.org/10.4103/sni.sni_25_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6069370PMC
July 2018
2 Reads

Sodium valproate versus phenytoin monotherapy for epilepsy: an individual participant data review.

Cochrane Database Syst Rev 2018 08 9;8:CD001769. Epub 2018 Aug 9.

Department of Biostatistics, University of Liverpool, Block F, Waterhouse Building, 1-5 Brownlow Hill, Liverpool, UK, L69 3GL.

Background: Epilepsy is a common neurological condition in which abnormal electrical discharges from the brain cause recurrent unprovoked seizures. It is believed that with effective drug treatment up to 70% of individuals with active epilepsy have the potential to become seizure-free, and to go into long-term remission shortly after starting drug therapy with a single antiepileptic drug in monotherapy.Worldwide, sodium valproate and phenytoin are commonly used antiepileptic drugs for monotherapy treatment. Read More

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http://doi.wiley.com/10.1002/14651858.CD001769.pub4
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http://dx.doi.org/10.1002/14651858.CD001769.pub4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6513104PMC
August 2018
4 Reads

[A case series of 4 epilepsy patients with promnesia].

Rinsho Shinkeigaku 2018 Aug 31;58(8):513-516. Epub 2018 Jul 31.

Department of Neurology, Kyoto University Graduate School of Medicine.

Promnesia is a feeling of familiarity and foreknowledge and is a manifestation of simple partial seizures (focal aware seizures). It is similar to déjà vu and has been reported to be a rare symptom in patients with temporal lobe epilepsy. Here, we investigated the clinical characteristics in 4 patients with partial epilepsy presenting promnesia. Read More

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http://dx.doi.org/10.5692/clinicalneurol.cn-001149DOI Listing
August 2018
6 Reads

Automated Detection of Convulsive Seizures Using a Wearable Accelerometer Device.

IEEE Trans Biomed Eng 2019 02 11;66(2):421-432. Epub 2018 Jun 11.

Epileptic seizure detection requires specialized approaches such as video/electroencephalography monitoring. However, these approaches are restricted mainly to hospital setting and requires video/EEG analysis by experts, which makes these approaches resource- and labor-intensive. In contrast, we aim to develop a wireless remote monitoring system based on a single wrist-worn accelerometer device, which is sensitive to multiple types of convulsive seizures and is capable of detecting seizures with short duration. Read More

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http://dx.doi.org/10.1109/TBME.2018.2845865DOI Listing
February 2019
57 Reads
2.347 Impact Factor

Lamotrigine versus carbamazepine monotherapy for epilepsy: an individual participant data review.

Cochrane Database Syst Rev 2018 06 28;6:CD001031. Epub 2018 Jun 28.

Department of Biostatistics, University of Liverpool, Block F, Waterhouse Building, 1-5 Brownlow Hill, Liverpool, UK, L69 3GL.

Background: This is an updated version of the original Cochrane Review published in Issue 11, 2006 of the Cochrane Database of Systematic Reviews.Epilepsy is a common neurological condition in which abnormal electrical discharges from the brain cause recurrent unprovoked seizures. It is believed that with effective drug treatment up to 70% of individuals with active epilepsy have the potential to become seizure-free, and to go into long-term remission shortly after starting drug therapy with a single antiepileptic drug (AED) in monotherapy. Read More

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http://dx.doi.org/10.1002/14651858.CD001031.pub4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6513029PMC
June 2018
26 Reads

[Classification of seizures and epilepsies].

Lakartidningen 2018 05 21;115. Epub 2018 May 21.

Karolinska Institutet Department of Clinical Neuroscience - Stockholm, Sweden Karolinska Institutet Department of Clinical Neuroscience - Stockholm, Sweden.

In 2017 the International League Against Epilepsy (ILAE) published position papers outlining new classifications of seizures and epilepsies. The aims of the new documents are to encompass advances in the field, provide a conceptual framework for future developments, and facilitate communication. In practice, the terminology is somewhat revised. Read More

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May 2018
4 Reads

The long-term outcomes of epilepsy surgery.

PLoS One 2018 16;13(5):e0196274. Epub 2018 May 16.

The Walton Centre, NHS Foundation Trust, Liverpool, Merseyside, United Kingdom.

Objective: Despite modern anti-epileptic drug treatment, approximately 30% of epilepsies remain medically refractory and for these patients, epilepsy surgery may be a treatment option. There have been numerous studies demonstrating good outcome of epilepsy surgery in the short to median term however, there are a limited number of studies looking at the long-term outcomes. The aim of this study was to ascertain the long-term outcome of resective epilepsy surgery in a large neurosurgery hospital in the U. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0196274PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5955551PMC
August 2018
15 Reads

Febrile Infection-Related Epilepsy Syndrome (FIRES): An Overview of Treatment and Recent Patents.

Recent Pat Inflamm Allergy Drug Discov 2018 ;12(2):128-135

Department of Pediatrics, Division of Child Neurology, Boston Medical Center, Boston University School of Medicine, Boston, MA 02118, United States.

Background: New-Onset Refractory Status Epilepticus (NORSE) refers to a clinical presentation in a patient without active epilepsy or other existing relevant neurological disorder, with new onset of refractory status epilepticus in the absence of a clear acute or active structural, metabolic, or toxic cause. Febrile Infection-Related Epilepsy Syndrome (FIRES) is a subset of NORSE that requires a febrile infection between 24 hours and 2 weeks prior to the onset of refractory status epilepticus, with or without fever at the onset of status epilepticus, and with no restriction to the age of the patient. The literature on FIRES is scarce. Read More

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http://dx.doi.org/10.2174/1872213X12666180508122450DOI Listing
December 2018
8 Reads
1 Citation

Averaging in time-frequency domain reveals the temporal and spatial extent of seizures recorded by scalp EEG.

Epileptic Disord 2018 Apr;20(2):132-138

Hôpital Erasme - ULB. Cliniques universitaires de Bruxelles. Route de Lennik 808 - B - 1070 Bruxelles, Belgium.

To demonstrate the importance of averaging in time-frequency space and the added localizing value in time and space in a case of cortical myoclonus. One hundred myoclonic jerks were averaged in time series and in spectral domain. For the latter, we chose 100 (10-second) segments from interictal background and used the unpaired t-test for the jerk-related and control spectral data to obtain the t value and corresponding p value at each pixel. Read More

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http://dx.doi.org/10.1684/epd.2018.0962DOI Listing
April 2018
4 Reads

Determination of topiramate by capillary electrophoresis with capacitively-coupled contactless conductivity detection: A powerful tool for therapeutic monitoring in epileptic patients.

Electrophoresis 2018 10 25;39(20):2598-2604. Epub 2018 Apr 25.

Department of Chemistry, Clemson University, Clemson, SC, USA.

Topiramate (TPM) is the main antiepileptic drug used for the control of partial and generalized seizures in both adults and children. In association with clinical observations, the analysis of plasmatic concentration of TPM is of utmost importance for the individual adjustment of the administered dose to the patient. In the present work, a bioanalytical method was developed and validated for TPM analysis in plasma samples by capillary electrophoresis with capacitively-coupled contactless conductivity detection (CE-C D). Read More

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http://dx.doi.org/10.1002/elps.201800046DOI Listing
October 2018
6 Reads

Precipitation and inhibition of seizures in focal epilepsies.

Expert Rev Neurother 2018 04 27;18(4):275-287. Epub 2018 Mar 27.

b Danish Epilepsy Centre , Dianalund , Denmark.

Introduction: There is growing awareness that reflex epileptic seizures offer unique insight into natural seizure generation in humans. In the last years, focus has mostly been on reflex seizures in generalized epilepsies whereas a comprehensive review of their role in focal epilepsies has been missing. Areas covered: This paper reviews reflex seizures strictly in focal epilepsies, not including focal reflex seizures in system epilepsies that also exist. Read More

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https://www.tandfonline.com/doi/full/10.1080/14737175.2018.1
Publisher Site
http://dx.doi.org/10.1080/14737175.2018.1455502DOI Listing
April 2018
20 Reads

Oxcarbazepine oral suspension in young pediatric patients with partial seizures and/or generalized tonic-clonic seizures in routine clinical practice in China: a prospective observational study.

World J Pediatr 2018 06 20;14(3):280-289. Epub 2018 Feb 20.

The third Department of Neurology, Guangdong 999 Brain Hospital, Guangzhou, China.

Background: This study aimed to assess efficacy and safety of oxcarbazepine (OXC) oral suspension in pediatric patients aged 2-5 years with partial seizures (PS) and/or generalized tonic-clonic seizures (GTCS) in real-world clinical practice in China.

Methods: This 26-week, prospective, single-arm, multicenter, observational study recruited pediatric patients aged 2-5 years with PS or GTCS suitable for OXC oral suspension treatment based on physicians' judgments from 11 medical centers in China. Enrolled subjects started OXC oral suspension treatment as monotherapy or in combination with other antiepileptic drugs. Read More

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http://dx.doi.org/10.1007/s12519-017-0114-6DOI Listing
June 2018
39 Reads

A Novel RNA Editing Sensor Tool and a Specific Agonist Determine Neuronal Protein Expression of RNA-Edited Glycine Receptors and Identify a Genomic APOBEC1 Dimorphism as a New Genetic Risk Factor of Epilepsy.

Front Mol Neurosci 2017 11;10:439. Epub 2018 Jan 11.

Division Cell Physiology, Zoological Institute, Technische Universität Braunschweig, Braunschweig, Germany.

C-to-U RNA editing of glycine receptors (GlyR) can play an important role in disease progression of temporal lobe epilepsy (TLE) as it may contribute in a neuron type-specific way to neuropsychiatric symptoms of the disease. It is therefore necessary to develop tools that allow identification of neuron types that express RNA-edited GlyR protein. In this study, we identify NH as agonist of C-to-U RNA edited GlyRs. Read More

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http://dx.doi.org/10.3389/fnmol.2017.00439DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768626PMC
January 2018
24 Reads

The production of IL-6 in acute epileptic seizure: A video-EEG study.

J Neuroimmunol 2018 03 15;316:50-55. Epub 2017 Dec 15.

Department of Neurology, Tampere University Hospital, Tampere, Finland; Department of Neurology, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.

Experimental and clinical reports highlight the role of cytokines in pathophysiological processes in underpinning epilepsy, but the clinical data remains somewhat limited. The levels of Interleukin (IL)-6 were measured in serum from 49 patients with refractory epilepsy [temporal lobe epilepsy (TLE, n=23), extratemporal lobe epilepsy (XLE, n=22), and idiopathic generalized epilepsy (IGE, n=4)] before and after the first verified seizure (IS; index seizure) during inpatient video-electroencephalographic (VEEG) monitoring. The levels of IL-6 increased significantly at all time points between 3h and 24h after the IS compared to the baseline. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2017.12.008DOI Listing
March 2018
10 Reads

Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data.

Cochrane Database Syst Rev 2017 12 15;12:CD011412. Epub 2017 Dec 15.

Department of Biostatistics, University of Liverpool, Block F, Waterhouse Building, 1-5 Brownlow Hill, Liverpool, UK, L69 3GL.

Background: Epilepsy is a common neurological condition with a worldwide prevalence of around 1%. Approximately 60% to 70% of people with epilepsy will achieve a longer-term remission from seizures, and most achieve that remission shortly after starting antiepileptic drug treatment. Most people with epilepsy are treated with a single antiepileptic drug (monotherapy) and current guidelines from the National Institute for Health and Care Excellence (NICE) in the United Kingdom for adults and children recommend carbamazepine or lamotrigine as first-line treatment for partial onset seizures and sodium valproate for generalised onset seizures; however a range of other antiepileptic drug (AED) treatments are available, and evidence is needed regarding their comparative effectiveness in order to inform treatment choices. Read More

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http://dx.doi.org/10.1002/14651858.CD011412.pub3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6486134PMC
December 2017
65 Reads

Auras and the risk of seizures with impaired consciousness following epilepsy surgery: implications for driving.

J Neurol Neurosurg Psychiatry 2018 06 9;89(6):599-602. Epub 2017 Dec 9.

Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, UK.

Objective: To calculate the chance of a seizure in the next year (COSY) for seizures with impaired awareness in those experiencing auras only, those with no seizures and those with continuing seizures. Epilepsy surgery is an effective treatment for refractory focal epilepsy. Driving is an important factor affecting quality of life. Read More

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http://dx.doi.org/10.1136/jnnp-2017-316578DOI Listing
June 2018
4 Reads

Understanding variability in driving recommendations for patients with seizures.

Epilepsy Behav 2017 12 5;77:44-49. Epub 2017 Nov 5.

Department of Neurology, North Shore University Hospital, Hofstra Northwell School of Medicine, 300 Community Drive, Manhasset, NY 11030, USA. Electronic address:

Background: There is lack of consensus regarding driving restrictions for patients with epilepsy. Regulations vary by state. New York State (NYS) recommends driving restrictions for one year in a person with an episode of loss of consciousness (LOC), with physician discretion. Read More

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http://dx.doi.org/10.1016/j.yebeh.2017.09.019DOI Listing
December 2017
16 Reads

Aphasic status epilepticus as the sole symptom of epilepsy: A case report and literature review.

Exp Ther Med 2017 Oct 21;14(4):3501-3506. Epub 2017 Aug 21.

Department of Neurosurgery, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China.

Aphasia is a common symptom encountered by neurologists. However, the presence of aphasia as the sole manifestation of partial status epilepticus is rare. The present study reports a case of aphasic status epilepticus in a 27-year-old right-handed female who presented after the abrupt onset of aphasia, which had persisted for 1. Read More

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http://dx.doi.org/10.3892/etm.2017.4979DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5639272PMC
October 2017
7 Reads

Risk of post-traumatic epilepsy after severe head injury in patients with at least one seizure.

Neuropsychiatr Dis Treat 2017 30;13:2301-2306. Epub 2017 Aug 30.

Department of Functional Neurosurgery, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.

Background: To explore the incidence and risk factors, including type of seizures for post-traumatic epilepsy (PTE) after severe traumatic brain injury (TBI).

Subjects And Methods: This was a retrospective follow-up study of patients discharged from Liaocheng People's Hospital between March 2011 and June 2015 with a diagnosis of post-traumatic seizures. Risk factors for PTE were evaluated in 68 inpatients by using Kaplan-Meier curves and the Cox model. Read More

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http://dx.doi.org/10.2147/NDT.S141486DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5587192PMC
August 2017
10 Reads

Seizure outcome after hippocampal deep brain stimulation in patients with refractory temporal lobe epilepsy: A prospective, controlled, randomized, double-blind study.

Epilepsia 2017 10 26;58(10):1728-1733. Epub 2017 Jul 26.

Mario Covas Hospital, Santo Andre, São Paulo, SP, Brazil.

Objective: We designed a prospective, randomized, controlled, double-blind study to evaluate the efficacy of hippocampal deep brain stimulation (Hip-DBS) in patients with refractory temporary lobe epilepsy (TLE).

Methods: Sixteen adult patients with refractory TLE were studied. Patient's workup included medical history, interictal and ictal electroencephalography (EEG), and high-resolution 1. Read More

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http://dx.doi.org/10.1111/epi.13860DOI Listing
October 2017
14 Reads

A case of epilepsy induced by eating or by visual stimuli of food made of minced meat.

Rinsho Shinkeigaku 2017 08 22;57(8):430-435. Epub 2017 Jul 22.

Department of Neurology, Kyoto University Graduate School of Medicine.

We report a 34-year-old woman with eating epilepsy induced not only by eating but also seeing foods made of minced meat. In her early 20s of age, she started having simple partial seizures (SPS) as flashback and epigastric discomfort induced by particular foods. When she was 33 years old, she developed SPS, followed by secondarily generalized tonic-clonic seizure (sGTCS) provoked by eating a hot dog, and 6 months later, only seeing the video of dumpling. Read More

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http://dx.doi.org/10.5692/clinicalneurol.cn-001001DOI Listing
August 2017
12 Reads

Smoking prevalence and seizure control in Chinese males with epilepsy.

Epilepsy Behav 2017 08 8;73:268-272. Epub 2017 Jul 8.

Department of Neurology, West China Hospital, Sichuan University, Chengdu, China. Electronic address:

Smoking has a negative effect on most diseases, yet it is under-investigated in people with epilepsy; thus its role is not clear in the general population with epilepsy. We performed a retrospective pilot study on males with epilepsy to determine the smoking rate and its relationship with seizure control using univariate analysis to calculate odds ratios (ORs) and also used a multi-variate logistic regression model. The smoking rate in our sample of 278 individuals was 25. Read More

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http://dx.doi.org/10.1016/j.yebeh.2017.04.008DOI Listing
August 2017
8 Reads

Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data.

Cochrane Database Syst Rev 2017 06 29;6:CD011412. Epub 2017 Jun 29.

Department of Biostatistics, University of Liverpool, Block F, Waterhouse Building, 1-5 Brownlow Hill, Liverpool, UK, L69 3GL.

Background: Epilepsy is a common neurological condition with a worldwide prevalence of around 1%. Approximately 60% to 70% of people with epilepsy will achieve a longer-term remission from seizures, and most achieve that remission shortly after starting antiepileptic drug treatment. Most people with epilepsy are treated with a single antiepileptic drug (monotherapy) and current guidelines from the National Institute for Health and Care Excellence (NICE) in the United Kingdom for adults and children recommend carbamazepine or lamotrigine as first-line treatment for partial onset seizures and sodium valproate for generalised onset seizures; however a range of other antiepileptic drug (AED) treatments are available, and evidence is needed regarding their comparative effectiveness in order to inform treatment choices. Read More

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http://dx.doi.org/10.1002/14651858.CD011412.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6481892PMC
June 2017
86 Reads

Quality of life, mood and seizure control in patients with brain tumor related epilepsy treated with lacosamide as add-on therapy: A prospective explorative study with a historical control group.

Epilepsy Behav 2017 08 14;73:83-89. Epub 2017 Jun 14.

Biostatistic Unit, Regina Elena National Cancer Institute, Via Elio Chianesi 53, Rome, Italy.

Objective: Brain tumor-related epilepsy (BTRE) is often drug resistant and patients can be forced to take polytherapy that can adversely affect their quality of life (QoL). Lacosamide (LCM) is a new antiepileptic drug (AED) used as adjunctive therapy in patients with partial seizures with or without secondary generalization, with a favorable pharmacokinetic profile that seems to be effective and well tolerated. Therefore it represents a possible therapeutic choice for patients with BTRE. Read More

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http://dx.doi.org/10.1016/j.yebeh.2017.05.031DOI Listing
August 2017
31 Reads

Hypothalamic hamartoma: Neuropathology and epileptogenesis.

Epilepsia 2017 06;58 Suppl 2:22-31

Hypothalamic Hamartoma Program and Division of Neurology, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, Arizona, U.S.A.

Hypothalamic hamartomas (HHs) are congenital malformations of the ventral hypothalamus resulting in treatment-resistant epilepsy and are intrinsically epileptogenic for the gelastic seizures that are the hallmark symptom of this disorder. This paper reviews the neuropathologic features of HHs associated with epilepsy, with an emphasis on characterizing neuron phenotypes and an ultimate goal of understanding the cellular model of ictogenesis occurring locally within this tissue. We also present previously unpublished findings on Golgi staining of HH. Read More

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http://dx.doi.org/10.1111/epi.13752DOI Listing
June 2017
51 Reads