10,485 results match your criteria Seizures Neonatal


Testicular androgens determining the incidence of spike-wave discharges in taiep rats: A model of H-ABC leukodystrophy.

Neurosci Lett 2022 May 17:136684. Epub 2022 May 17.

Institute of Physiology. Av. 14 Sur # 6301. Col. Jardínes de San Manuel. Puebla, Pue. C.P. 72570, México; International Office, Benemérita Universidad Autónoma de Puebla. Torre de Gestión Académica y Servicios Administrativos, 3(er) piso. Col. Jardínes de San Manuel. Puebla, Pue. C.P. 72570, México. Electronic address:

Absence seizures are characterized as a generalized type of epilepsy that occurs during childhood. Importantly, absence seizures in children often discontinue after puberty. There is limited availability of animal models in which electroencephalography (EEG) can be performed in the long term; however, two absence seizure models, GAERS and WAG/Rij albino rats, are available. Read More

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Association of Maternal Obesity and Neonatal Hypoxic-Ischemic Encephalopathy.

Front Pediatr 2022 29;10:850654. Epub 2022 Apr 29.

Department of Pediatrics, Bernard and Millie Duker Children's Hospital at Albany Medical Center, Albany, NY, United States.

Objective: More women are obese at their first prenatal visit and then subsequently gain further weight throughout pregnancy than ever before. The impact on the infant's development of neonatal hypoxic ischemic encephalopathy (HIE) has not been well studied. Using defined physiologic and neurologic criteria, our primary aim was to determine if maternal obesity conferred an additional risk of HIE. Read More

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The Negative Association between Breastfeeding Duration and Infant Febrile Seizure: A Retrospective Case-Control Study.

Int J Environ Res Public Health 2022 May 1;19(9). Epub 2022 May 1.

Department of Obstetrics and Gynecology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Tzu Chi University, Hualien 970, Taiwan.

Two to five percent of infants and children experience febrile seizures (FS). Breastfeeding is beneficial to the health of mothers and children. Nevertheless, the benefits of breastfeeding in reducing FS remain unclear; thus, the present study aimed to evaluate this association. Read More

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Dexmedetomidine Versus Fentanyl for Neonates With Hypoxic Ischemic Encephalopathy Undergoing Therapeutic Hypothermia.

J Pediatr Pharmacol Ther 2022 9;27(4):352-357. Epub 2022 May 9.

Department of Pharmacy, University of Chicago Medicine Comer Children's Hospital, Chicago, IL.

Objective: Therapeutic hypothermia reduces the risk of death and major disability in neonates with moderate-to-severe hypoxic ischemic encephalopathy (HIE). Opioids and benzodiazepines are used to manage agitation but contribute to hemodynamic and respiratory instability. The objective of this study was to evaluate the safety and efficacy of dexmedetomidine (DEX) compared with fentanyl (FENT) in neonates with HIE undergoing therapeutic hypothermia. Read More

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Clinical Study of 30 Novel Variants/Deletions in -Related Disorders.

Front Mol Neurosci 2022 26;15:809810. Epub 2022 Apr 26.

Department of Neonatology, National Children's Medical Center, Children's Hospital of Fudan University, Shanghai, China.

Background: -related disorder is typically characterized as neonatal onset seizure and epileptic encephalopathy. The relationship between its phenotype and genotype is still elusive. This study aims to provide clinical features, management, and prognosis of patients with novel candidate variants of the gene. Read More

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From Wolf-Hirschhorn syndrome to NSD2 haploinsufficiency: a shifting paradigm through the description of a new case and a review of the literature.

Ital J Pediatr 2022 May 12;48(1):72. Epub 2022 May 12.

Department of Molecular Medicine, University of Pavia, Pavia, Italy.

Background: Wolf-Hirschhorn syndrome (WHS) is a well-defined disorder, whose core phenotype encompasses growth restriction, facial gestalt, intellectual disability and seizures. Nevertheless, great phenotypic variability exists due to the variable extent of the responsible 4p deletion. In addition, exome sequencing analyses, recently identified two genes, namely NSD2 and NELFA, whose loss-of-function variants contribute to a clinical spectrum consistent with atypical or partial WHS. Read More

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Maternal Serotonergic Antidepressant Use in Pregnancy and Risk of Seizures in Children.

Neurology 2022 May 11. Epub 2022 May 11.

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

Objective: To evaluate whether children born to women who use serotonergic antidepressants during pregnancy have higher risk of neonatal seizures and epilepsy.

Methods: We used Swedish register-based data to examine associations between maternal-reported use of selective-serotonin reuptake inhibitor (SSRI) and selective serotonin-norepinephrine reuptake inhibitors (SNRI) in pregnancy and diagnosis of neonatal seizures and/or epilepsy in over 1.2 million children. Read More

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Efficacy and Utilization Patterns of Anti-Epileptic Drugs in the Management of Neonatal Seizures: A Comparative Exploration.

Neurol India 2022 Mar-Apr;70(2):574-578

Department of Neonatology, Kasturba Medical College, Manipal, Karnataka, India.

Background: Management of neonatal seizures with available limited guidelines across different gestation can cause long-term neurological and cognitive impairment.

Objectives: To compare utilization and observe the efficacy of anti-epileptic drugs in the treatment of neonatal seizures. The association of hypoxic-ischemic encephalopathy with NS and the etiology of HIE were also determined. Read More

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Atypical Eclampsia in a Pregnant Woman Infected by COVID-19.

Case Rep Obstet Gynecol 2022 27;2022:9952355. Epub 2022 Apr 27.

Makassed Islamic Charitable Society, Jerusalem, State of Palestine.

The coronavirus disease 2019, also called (COVID-19), is an infectious disease which is caused by a virus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The first report was in December 2019, and on March 12, 2020, the World Health Organization (WHO) declared this disease a pandemic. COVID-19 targets many major organs causing life-threatening systemic complications. Read More

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Fever-Associated Seizures or Epilepsy: An Overview of Old and Recent Literature Acquisitions.

Front Pediatr 2022 21;10:858945. Epub 2022 Apr 21.

Unit of Rare Diseases of the Nervous System in Childhood, Department of Clinical and Experimental Medicine, Section of Pediatrics and Child Neuropsychiatry, University of Catania, AOU "Policlinico", PO "G. Rodolico", Catania, Italy.

In addition to central nervous system infections, seizures and fever may occur together in several neurological disorders. Formerly, based on the clinical features and prognostic evolution, the co-association of seizure and fever included classical febrile seizures (FS) divided into simple, complex, and prolonged FS (also called febrile status epilepticus). Later, this group of disorders has been progressively indicated, with a more inclusive term, as "fever-associated seizures or epilepsy" (FASE) that encompasses: (a) FS divided into simple, complex, and prolonged FS; (b) FS plus; (c) severe myoclonic epilepsy in infancy (Dravet syndrome); (d) genetic epilepsy with FS plus; and (e) febrile infection-related epilepsy syndrome (FIRES). Read More

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Bumetanide for neonatal seizures: no light in the pharmacokinetic/dynamic tunnel.

Epilepsia 2022 May 6. Epub 2022 May 6.

Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, Germany.

In his editorial, Kevin Staley criticizes our recent work demonstrating the lack of effect of bumetanide in a novel model of neonatal seizures. The main points in our response are that (i) our work is on an asphyxia model, not one on 'hypercarbia-only'; (ii) clinically relevant parenteral doses of bumetanide applied in vivo lead to concentrations in the brain parenchyma which are at least an order of magnitude lower than what would be sufficient to exert any direct effect - even a transient one - on neuronal functions, including neonatal seizures. Moreover, (iii) bumetanide's molecular target in the brain is the Na-K-2Cl cotransporter NKCC1, which has vital functions in neurons, astrocytes, oligodendrocytes as well as microglia. Read More

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Clarifications regarding bumetanide for neonatal seizures.

Authors:
Kevin J Staley

Epilepsia 2022 May 6. Epub 2022 May 6.

Neurology Department, Massachusetts General Hospital, Harvard Medical School.

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Translational neonatal seizure research - a reality check.

Epilepsia 2022 May 6. Epub 2022 May 6.

INFANT Research Centre, University College Cork, Ireland.

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Lissencephaly causing refractory neonatal seizures in a term neonate.

BMJ Case Rep 2022 05 6;15(5). Epub 2022 May 6.

Neonatal Intensive Care Unit (NICU), Women's Wellness and Research Center (WWRC), Hamad Medical Corporation (HMC), Doha, Qatar

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Novel Heterozygous Missense Variant in GRIA4 Gene Associated With Neurodevelopmental Disorder With or Without Seizures and Gait Abnormalities.

Front Genet 2022 20;13:859140. Epub 2022 Apr 20.

Chigene (Beijing) Translational Medical Research Center Co., Ltd., Beijing, China.

Neurodevelopmental disorder with or without seizure and gait abnormalities (NEDSGA, MIM * 617864) is a newly described autosomal dominant inherited disease caused by a heterozygous variant in the GRIA4 gene. plays an essential role in excitatory synaptic transmission. In this study, we presented the clinical and genetic features of a female patient carrying a novel variant in and further reviewed the previously reported five different patients. Read More

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Multiple Early-life Seizures Alters Neonatal Communicative Behavior in Fmr1 Knockout Mice.

Dev Neurosci 2022 May 5. Epub 2022 May 5.

Fragile X syndrome (FXS) is the leading monogenic cause of intellectual disability and a significant contributor to Autism Spectrum Disorder. Individuals with FXS are subject to developing numerous comorbidities, one of the most prevalent being seizures. In the present study, we investigated how seizures affected neonatal communicative behavior in the FXS mouse model. Read More

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[Brain-lung-thyroid syndrome in a newborn with deletion 14q12-q21.1].

Andes Pediatr 2021 Dec 5;92(6):930-936. Epub 2021 Nov 5.

Servicios Médicos Yunis Turbay y CIA, Bogotá, Colombia.

Introduction: In newborns with respiratory failure and interstitial lung disease, it should be approached as chILD (Childhood Interstitial Lung Disease) syndrome to rule out alterations in surfactant metabolism and brain-lung-thyroid syndrome caused by pathogenic variants in the NKX2-1 gene.

Objective: To pre sent a newborn with chILD syndrome and a large deletion in chromosome 14q12-q21.1. Read More

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December 2021

Associations of severe adverse perinatal outcomes among continuous birth weight percentiles on different birth weight charts: a secondary analysis of a cluster randomized trial.

BMC Pregnancy Childbirth 2022 Apr 30;22(1):375. Epub 2022 Apr 30.

Department of Midwifery Science, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, AVAG/Amsterdam Public Health, Amsterdam, Netherlands.

Objective: To identify neonatal risk for severe adverse perinatal outcomes across birth weight centiles in two Dutch and one international birth weight chart.

Background: Growth restricted newborns have not reached their intrinsic growth potential in utero and are at risk of perinatal morbidity and mortality. There is no golden standard for the confirmation of the diagnosis of fetal growth restriction after birth. Read More

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Long-term outcome of developmental and epileptic encephalopathies.

Authors:
P Van Bogaert

Rev Neurol (Paris) 2022 Apr 27. Epub 2022 Apr 27.

Department of Pediatric Neurology, CHU d'Angers, and Laboratoire Angevin de Recherche en Ingénierie des Systèmes (LARIS), Université d'Angers, 4, rue Larrey, 49000 Angers, France. Electronic address:

Developmental and epileptic encephalopathies are conditions where there is developmental impairment related to both the underlying etiology independent of epileptiform activity and the epileptic encephalopathy. Usually they have multiple etiologies. Therefore, long-term outcome is related to both etiology-related factors and epilepsy-related factors-age at onset of epilepsy, type(s) of seizure(s), type of electroencephalographic abnormalities, duration of the epileptic disorder. Read More

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The association of fetal acidemia with adverse neonatal outcomes at time of scheduled cesarean delivery.

Am J Obstet Gynecol 2022 Apr 27. Epub 2022 Apr 27.

Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO.

Background: Fetal acidemia at the time of a scheduled cesarean delivery is generally unexpected. In the setting of reassuring preoperative monitoring, the duration of fetal acidemia in this scenario is presumably brief. The neonatal sequelae and risks associated with brief fetal acidemia in this setting are unknown. Read More

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Response of focal refractory status epilepticus to lacosamide in an infant.

BMJ Case Rep 2022 Apr 29;15(4). Epub 2022 Apr 29.

Pediatric Critical Care, University of Illinois College of Medicine at Peoria (UICOMP), Peoria, Illinois, USA.

Status epilepticus (SE) is a life-threatening medical emergency which is frequently encountered in the critical care setting and can be refractory to treatment. Refractory status epilepticus (RSE) is defined as SE that has failed to respond to adequately used first-line and second-line antiepileptic medications. Super refractory status epilepticus is defined as SE that persists for 24 hours or more after the use of an anaesthetic agent or recurs after its withdrawal. Read More

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Neonatal morbidity and mortality for preterm in breech presentation regarding the onset mode of labor.

Arch Gynecol Obstet 2022 Apr 27. Epub 2022 Apr 27.

Service de Gynécologie Obstétrique, Assistance Publique-Hôpitaux de Paris, Hôpital Robert Debré, Paris, France.

Purpose: To assess severe neonatal morbidity and mortality in induced labor in preterm breech deliveries, compared to spontaneous labor.

Methods: This is a retrospective study conducted in a tertiary university center in France. Women with single live breech pregnancy between 28 + 0 and 36 + 6 weeks gestation were included. Read More

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Cerebral white matter abnormalities associated with chromosome 18q duplication.

Brain Dev 2022 Apr 22. Epub 2022 Apr 22.

Research Institute of the McGill University Medical Centre, Montreal, Quebec, Canada; Division of Neurology, Department of Pediatrics, Montreal Children's Hospital, McGill University Health Centre, Montreal, Quebec, Canada; Department of Neurology and Neurosurgery, McGill University Health Centre, Montreal, Quebec, Canada. Electronic address:

Background: Chromosome 18q duplications are associated with a range of phenotypes often similar to complete trisomy 18, variably including poor growth, feeding difficulties, congenital malformations and dysmorphic facial features. Although 18q duplication patients may have seizures and developmental impairment, brain MRI typically shows only variable degrees of cerebral atrophy.

Patient: We present a boy with a 52. Read More

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Seizure Characteristics and Background Amplitude-Integrated Electroencephalography Activity in Neonatal Rats Subjected to Hypoxia-Ischemia.

Front Pediatr 2022 7;10:837909. Epub 2022 Apr 7.

Department of Pediatrics, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

Objective: Perinatal hypoxic-ischemic encephalopathy (HIE) is a major cause of epilepsy and chronic neurologic morbidity in premature infants. This study aimed to investigate the characteristics of acute seizures and the pattern of background activity on amplitude-integrated electroencephalography (aEEG) in neonatal rats with HIE.

Methods: Hypoxia-ischemia (HI) was induced in postnatal day (P) 3 neonatal rats (n = 12) by ligation of the left carotid artery and exposure to airtight hypoxia for 2 h. Read More

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Outcome of Neonates Presenting With Severe Cardiac Failure due to Cerebral Arteriovenous Fistula.

Pediatr Neurol 2022 Apr 14;131:25-29. Epub 2022 Apr 14.

Department of Pediatrics and Benioff Children's Hospital, University of California San Francisco, San Francisco, California; Department of Neurology and Weill Institute for Neurosciences, University of California San Francisco, San Francisco, California. Electronic address:

Background: Congenital cerebral arteriovenous fistulas (AVFs), including vein of Galen malformations, presenting in infancy carry variable mortality and morbidity. This study aimed to describe the outcome of neonates with cerebral AVFs who present with refractory cardiac failure.

Methods: Retrospective chart review of neonates with refractory cardiac failure due to cerebral AVFs presenting before 28 days of age in a single-center neuro-intensive care nursery over a 12-year period (2008-2020) was conducted. Read More

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Early MRI diagnosis of Sturge Weber Syndrome type 1 in infants.

Eur J Paediatr Neurol 2022 Apr 13;38:66-72. Epub 2022 Apr 13.

Department of Neuroradiology, ErasmusMC- Sophia Children's Hospital, Rotterdam, the Netherlands.

Background: Patients with Sturge-Weber syndrome type 1 (SWS1) have a port-wine birthmark (PWB) as cutaneous hallmark. Up to 35% of neonates with a high risk PWB develop SWS1. Clinical manifestations are severe and often progressive. Read More

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Modified Time-Frequency Marginal Features for Detection of Seizures in Newborns.

Sensors (Basel) 2022 Apr 15;22(8). Epub 2022 Apr 15.

Department of Information and Communicaiton, Yeungnam University, Gyeongsan 38541, Korea.

The timely detection of seizure activity in the case of newborns can help save lives. Clinical signs of seizures in newborns are difficult to observe, so, in this study, we propose an automated method of detecting seizures in newborns using multi-channel electroencephalogram (EEG) recording acquired from 36 newborns admitted to Royal Women's Hospital, Brisbane, Australia. A novel set of time-frequency marginal features are defined to detect seizure activity in newborns. Read More

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Heart Rate Variability Analysis for Seizure Detection in Neonatal Intensive Care Units.

Bioengineering (Basel) 2022 Apr 7;9(4). Epub 2022 Apr 7.

Department of Information Engineering, Università degli Studi di Firenze, Via Santa Marta 3, 50139 Firenze, Italy.

In Neonatal Intensive Care Units (NICUs), the early detection of neonatal seizures is of utmost importance for a timely clinical intervention. Over the years, several neonatal seizure detection systems were proposed to detect neonatal seizures automatically and speed up seizure diagnosis, most based on the EEG signal analysis. Recently, research has focused on other possible seizure markers, such as electrocardiography (ECG). Read More

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Therapeutic hypothermia in neonatal hypoxic encephalopathy: A systematic review and meta-analysis.

J Glob Health 2022 9;12:04030. Epub 2022 Apr 9.

Kasturba Medical College, Manipal, India.

Background: Therapeutic hypothermia (TH) is regarded as the most efficacious therapy for neonatal hypoxic encephalopathy. However, limitations in previous systematic reviews and the publication of new data necessitate updating the evidence. We conducted this up-to-date systematic review to evaluate the effects of TH in neonatal encephalopathy on clinical outcomes. Read More

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