116,708 results match your criteria Seizures


Influence of salbutamol on the anticonvulsant potency of the antiepileptic drugs in the maximal electroshock-induced seizures in mice.

Pharmacol Rep 2019 Feb 8;71(3):466-472. Epub 2019 Feb 8.

Department of Experimental and Clinical Pharmacology, Medical University, Lublin, Poland.

Background: β-Adrenergic receptor agonists are widely used agents in the treatment of asthma or preterm labor. Since prevalence of asthma was shown to be higher in patients with epilepsy and modulation of noradrenergic system activity may modify epilepsy course, the aim of the present study was to examine the effect of salbutamol (SALB), one of the most commonly used β-adrenergic receptor agonist on the anticonvulsant potency of four classical antiepileptic drugs (AEDs): valproate (VPA), carbamazepine (CBZ), phenytoin (DPH) and phenobarbital (PB) in mice subjected to the maximal electroshock (MES)-induced seizures.

Methods: Seizures were caused by a current delivered through ear-clip electrodes. Read More

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http://dx.doi.org/10.1016/j.pharep.2019.02.003DOI Listing
February 2019

Seizure control by low-intensity ultrasound in mice with temporal lobe epilepsy.

Epilepsy Res 2019 Apr 4;154:1-7. Epub 2019 Apr 4.

State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, 100875, China. Electronic address:

Background: Temporal lobe epilepsy (TLE) is the most common form of focal epilepsy. Recent studies have demonstrated that ultrasound stimulation can inhibit spontaneous recurrent seizures and improve behavioral outcomes for rodents with TLE. However, the exact underlying mechanism for inhibition of TLE via ultrasound stimulation remains unknown. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2019.04.002DOI Listing

The clinical presentation caused by truncating CHD8 variants.

Clin Genet 2019 Apr 18. Epub 2019 Apr 18.

Manchester Centre for Genomic Medicine, St Mary's Hospital, Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Sciences Centre, United Kingdom.

Variants in the chromodomain helicase DNA-binding protein 8 (CHD8) have been associated with intellectual disability (ID), autism spectrum disorders (ASD) and overgrowth and CHD8 is one of the causative genes for OGID (overgrowth and ID). We investigated 25 individuals with CHD8 protein truncating variants (PTVs), including 10 previously unreported patients and found a male to female ratio of 2.7:1 (19:7) and a pattern of common features: macrocephaly (62. Read More

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http://doi.wiley.com/10.1111/cge.13554
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http://dx.doi.org/10.1111/cge.13554DOI Listing
April 2019
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S-Sulfocysteine Induces Seizure-Like Behaviors in Zebrafish.

Front Pharmacol 2019 2;10:122. Epub 2019 Apr 2.

Institute of Plant Biology, TU Braunschweig, Braunschweig, Germany.

Sulfite is a neurotoxin, which is detoxified by the molybdenum cofactor (Moco)-dependent enzyme sulfite oxidase (SOX). In humans, SOX deficiency causes the formation of the glutamate analog S-Sulfocysteine (SSC) resulting in a constant overstimulation of ionotropic glutamatergic receptors. Overstimulation leads to seizures, severe brain damage, and early childhood death. Read More

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http://dx.doi.org/10.3389/fphar.2019.00122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454129PMC

Low-Intensity Pulsed Ultrasound Stimulation Modulates the Nonlinear Dynamics of Local Field Potentials in Temporal Lobe Epilepsy.

Front Neurosci 2019 2;13:287. Epub 2019 Apr 2.

Institute of Electrical Engineering, Yanshan University, Qinhuangdao, China.

Low-intensity pulsed ultrasound stimulation (LIPUS) can inhibit seizures associated with temporal lobe epilepsy (TLE), which is the most common epileptic syndrome in adults and accounts for more than half of the cases of intractable epilepsy. Electroencephalography (EEG) signal analysis is an important method for studying epilepsy. The nonlinear dynamics of epileptic EEG signals can be used as biomarkers for the prediction and diagnosis of epilepsy. Read More

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http://dx.doi.org/10.3389/fnins.2019.00287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454000PMC

The Impact of Affective State on Quality of Life in Focal Epilepsy in Turkey.

J Neurosci Rural Pract 2019 Apr-Jun;10(2):267-272

Department of Neurology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.

Context: Seizures and accompanying situations including social, medical, and psychiatric problems threaten the quality of life (QOL) in patients with epilepsy. The World Health Organization defines health is a state of complete physical, mental, and social well-being, and not merely the absence of disease or infirmity.

Aims: This study examines the prevalence of both depression and anxiety symptoms and also impact of the affective state on QOL in patients with focal epilepsy in Turkey. Read More

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http://dx.doi.org/10.4103/jnrp.jnrp_324_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454954PMC

Impact of Etiology on Efficacy of Oral Triclofos in Recording Pediatric Electroencephalography: A Tertiary Care Center Study.

J Neurosci Rural Pract 2019 Apr-Jun;10(2):234-237

Department of Neurology, Niloufer Children's Hospital, Hyderabad, Telangana, India.

Background And Objectives: Oral triclofos is a frequently used sedative in pediatric age to record sleep Electroencephalography (EEG). This study is aimed to assess efficacy, safety profile, need for second dose, and rescheduling of oral triclofos in relation to etiology.

Materials And Methods: This is a retrospective study done enrolling all children aged 6 months to 5 years referred for EEG over 1 year. Read More

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http://dx.doi.org/10.4103/jnrp.jnrp_280_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454965PMC

Long-Term Surface Electrode Impedance Recordings Associated with Gliosis for a Closed-Loop Neurostimulation Device.

Ann Neurosci 2018 Dec 14;25(4):289-298. Epub 2019 Jan 14.

Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, Wisconsin, USA.

Background: Closed-loop neurostimulation is a novel alternative therapy for medically intractable focal epilepsy for patients who are not candidates for surgical resection of a seizure focus. Electrodes for this system can be implanted either within the brain parenchyma or in the subdural space. The electrodes then serve the dual role of detecting seizures and delivering an electrical signal aimed at aborting seizure activity. Read More

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http://dx.doi.org/10.1159/000481805DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470334PMC
December 2018

Prevalence, Demographic Profile, and Psychological Aspects of Epilepsy in North-Western India: A Community-Based Observational Study.

Ann Neurosci 2018 Dec 12;25(4):177-186. Epub 2018 Jun 12.

Professor Preventive and Social Medicine, SMS Medical College, Jaipur, India.

Aims: This study was undertaken to determine the prevalence of active epilepsy, assess the sociodemographic profile, and psychological aspects of epilepsy in the Jaipur district of Rajasthan, India.

Methods: We conducted a community-based, cross-sectional observational study covering both rural ( = 165,660) and urban ( = 179,142) populations of Jaipur district using a house-to-house survey. An adapted, pre-designed World Health Organization screening questionnaire was used to identify the cases. Read More

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https://www.karger.com/Article/FullText/487072
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http://dx.doi.org/10.1159/000487072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470329PMC
December 2018
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Congenital biotinidase deficiency - MRI findings in two cases.

Indian J Radiol Imaging 2019 Jan-Mar;29(1):99-103

Consultant Radiologist, Vikas Diagnostics, Kanpur, Uttar Pradesh, India.

Congenital biotinidase deficiency is a rare inborn error of metabolism that most commonly presents in infantile age group. Diffusion changes on magnetic resonance imaging (MRI) are sparsely described in the literature. We are presenting diffusion-weighted MRI findings in two confirmed cases of congenital biotinidase deficiency in infantile age group with review of literature. Read More

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http://www.ijri.org/text.asp?2019/29/1/99/255223
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http://dx.doi.org/10.4103/ijri.IJRI_159_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467045PMC
April 2019
1 Read

Retrospective Study of Patients with Hyperphenylalaninemia- Experience from a Tertiary Care Center in Pakistan.

J Pak Med Assoc 2019 Apr;69(4):509-513

Department of Paediatrics and Child Health, Aga Khan University, Karachi.

Objective: To assess the clinical and biochemical features as well as outcome of hyperphenylalaninemia patients.

Methods: The descriptive retrospective study was conducted at the Aga Khan University Hospital, Karachi, and comprised data from January 2013 to February 2017 of plasma amino acid analysed at the Biochemical Genetic Laboratory of patients with phenylalanine levels >120 umol/L. Medical charts of patients registered with the Metabolic Clinics were reviewed, while outside referrals were contacted by telephone to collect data on a pre-structured questionnaire. Read More

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April 2019
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The neurological syndromes associated with glutamic acid decarboxylase antibodies.

J Autoimmun 2019 Apr 15. Epub 2019 Apr 15.

Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, TX, USA; University of Guanajuato, Mexico. Electronic address:

A number of neurological syndromes have been described in patients with positive serum antibodies (Abs) against the enzyme glutamic acid decarboxylase (GAD), the rate limiting step in the synthesis of GABA (γ-aminobutyric acid). These disorders include: classical stiff-person syndrome and variants, cerebellar ataxia, limbic and extra-limbic encephalitis, nystagmus/oculomotor dysfunction, drug-resistant epilepsy, paraneoplastic stiff-person syndrome and progressive encephalopathy with rigidity and myoclonus (PERM), the latter two are mainly related to amphiphysin and the glycine receptor Abs respectively; but patients may also have positive GAD-Abs. Although observations are consistent with an autoimmune response in these patients and there is evidence of GABAergic dysfunction in some cases; the pathogenic role of GAD-Abs in the nervous system has not been clarified and it is a matter of debate. Read More

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http://dx.doi.org/10.1016/j.jaut.2019.04.007DOI Listing
April 2019
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Findings of amplitude-integrated electroencephalogram recordings and serum vitamin B6 metabolites in perinatal lethal hypophosphatasia during enzyme replacement therapy.

Brain Dev 2019 Apr 15. Epub 2019 Apr 15.

Division of Neonatology, Center for Maternal-Neonatal Care, Nagoya University Hospital, Nagoya, Japan.

Hypophosphatasia (HPP) is a rare disorder caused by low serum tissue non-specific alkaline phosphatase (ALP) activity due to hypomorphic mutations in the ALPL gene. HPP is characterized by defective bone mineralization. It frequently accompanies pyridoxine-responsive seizures. Read More

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http://dx.doi.org/10.1016/j.braindev.2019.03.015DOI Listing

Catastrophic Cerebellitis in an adolescent: A Case Report.

Oman Med J 2014 Jul;29(4):e075

Second year Resident, Radiology, Jawaharlal Nehru Medical College, Sawangi Meghe, Wardha 442005, Maharashtra, India.

An adolescent presented with headache and projectile vomiting and showed ataxia, dysarthia and nystagmus with normal cognition. A diagnosis of acute cerebellitis was made on the basis of computed tomography and magnetic resonance imaging findings. He developed seizures and had a rapid downhill course with death at 48 hours after admission. Read More

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http://dx.doi.org/10.5001/omj.2014.84DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451758PMC
July 2014
1 Read

Meningioma and psychiatric symptoms: An individual patient data analysis.

Asian J Psychiatr 2019 Mar 28;42:94-103. Epub 2019 Mar 28.

Department of Psychiatry, Dr Ram Manohar Lohia Hospital PGIMER, New Delhi, India.

Meningioma is a slow-growing benign tumor arising from meninges and is usually asymptomatic. Though neuropsychiatric symptoms are common in patients with brain tumors, they often can be the only manifestation in cases of meningioma. Meningiomas might present with mood symptoms, psychosis, memory disturbances, personality changes, anxiety, or anorexia nervosa. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18762018183113
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http://dx.doi.org/10.1016/j.ajp.2019.03.029DOI Listing
March 2019
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Long-term safety and efficacy following conversion to eslicarbazepine acetate monotherapy in adults with focal seizures.

Epilepsy Res 2019 Mar 29;153:59-65. Epub 2019 Mar 29.

Sunovion Pharmaceuticals Inc., 84 Waterford Drive, Marlborough, MA, 01752, USA.

Objective: To assess the long-term safety and efficacy of eslicarbazepine acetate (ESL) monotherapy in adults with focal seizures (FS).

Methods: Study 050 was a long-term, multicenter, open-label (OL) safety extension of two conversion-to-ESL monotherapy studies in adults with refractory FS. After participating in Study 045 or 046, patients started on ESL 1600 mg once daily (QD) (or 1200 mg if they previously had a dose reduction), and could adjust the dose 400 mg/week to a dose between 800-2400 mg QD. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2019.03.018DOI Listing

Unverricht-Lundborg disease: Clinical course and seizure management based on the experience of polish centers.

Authors:
Anetta Lasek-Bal

Seizure 2019 Apr 10;69:87-91. Epub 2019 Apr 10.

Department of Neurology, School of Health Sciences, Medical University of Silesia in Katowice, 40-635, Katowice, Poland. Electronic address:

The purpose of this paper was to present our experience following the longterm treatment of 11 patients with Unverricht-Lundborg disease (ULD) confirmed by molecular testing.

Methods: We analyzed the clinical course, cognitive state, neuroimaging and neurophysiology results.

Results: The data were collected from 9 unrelated families (F/M: 4/7) aged 25-49. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10591311183065
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http://dx.doi.org/10.1016/j.seizure.2019.04.008DOI Listing
April 2019
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Excitatory-inhibitory imbalance in Alzheimer's disease and therapeutic significance.

Neurobiol Dis 2019 Apr 15. Epub 2019 Apr 15.

Department of Psychiatry, McGill University, Montreal, Quebec, Canada. Electronic address:

The interplay between excitatory and inhibitory circuits underlies the brain's processes and their dysregulation has been linked to cognitive decline, psychiatric disorders and epilepsy. In patients with Alzheimer's disease (AD), an elevated occurrence of seizures has been observed in both sporadic and familial forms of the condition. Although seizure activity in AD has been mainly viewed as a result of neuronal cell loss and considered to occur in later stages, it is now becoming increasingly clear that aberrant neuronal activity may be more common in patients at earlier stages than previously thought and may trigger and contribute significantly to cognitive defects. Read More

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http://dx.doi.org/10.1016/j.nbd.2019.04.010DOI Listing
April 2019
2 Reads

[Lamotrigine induced hypersensitivity syndrome in children: a case report].

Authors:
N X Cui X P Zhu

Beijing Da Xue Xue Bao Yi Xue Ban 2019 Apr;51(2):356-358

Department of Neonatology, Children's Hospital of Soochow University, Suzhou 215025, Jiangsu, China.

Drug induced hypersensitivity syndrome (DIHS) is often manifested as severe systemic drug trans-reactions characterized by acute and extensive skin lesions (mostly measles-like rash), fever, enlargement of lymph nodes, multiple organ involvement (hepatitis, nephritis, and pneumonia), eosinophilia and mononucleosis,within 2-6 weeks of the application of sensitizing drugs. In the early stage of the lesion, macular papules or erythema multiforme were common, and in severe cases, exfoliative dermatitis, Stevens-Johnson syndrome and toxic epidermal necrolysis were also common. Most of them developed after taking allergic drugs for 2-6 weeks (average: 3 weeks). Read More

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April 2019
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[Chronic phosphoproteomic in temporal lobe epilepsy mouse models induced by kainic acid].

Beijing Da Xue Xue Bao Yi Xue Ban 2019 Apr;51(2):197-205

Institute of Systems Biomedicine, State Key Laboratory of Natural and Biomimetic Drugs, Department of Molecular and Cellular Pharmacology, Peking University School of Pharmaceutical Science, Beijing 100191, China.

Objective: To investigate functions of proteins and signaling pathways involved in epileptogenesis during the chronic stage of temporal lobe epilepsy in mouse models.

Methods: Kainic acid-induced temporal lobe epilepsy models were conducted, when reaching stage 4 using racine scale, the mice of experimental group were supposed to be successfully established. Pentobarbital sodium was injected to stop epileptic seizure in case of death. Read More

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Delayed maturation of GABAergic signaling in the Scn1a and Scn1b mouse models of Dravet Syndrome.

Sci Rep 2019 Apr 17;9(1):6210. Epub 2019 Apr 17.

Department of Pharmacology, University of Michigan, Ann Arbor, MI, 48109-5632, USA.

Dravet syndrome (DS) is a catastrophic developmental and epileptic encephalopathy characterized by severe, pharmacoresistant seizures and the highest risk of Sudden Unexpected Death in Epilepsy (SUDEP) of all epilepsy syndromes. Here, we investigated the time course of maturation of neuronal GABAergic signaling in the Scn1b and Scn1a mouse models of DS. We found that GABAergic signaling remains immature in both DS models, with a depolarized reversal potential for GABA-evoked currents compared to wildtype in the third postnatal week. Read More

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http://www.nature.com/articles/s41598-019-42191-0
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http://dx.doi.org/10.1038/s41598-019-42191-0DOI Listing
April 2019
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Intracellular Peptides in Cell Biology and Pharmacology.

Biomolecules 2019 Apr 16;9(4). Epub 2019 Apr 16.

Department of Pharmacology, Biomedical Sciences Institute, University of São Paulo (USP), São Paulo 05508-000, Brazil.

Intracellular peptides are produced by proteasomes following degradation of nuclear, cytosolic, and mitochondrial proteins, and can be further processed by additional peptidases generating a larger pool of peptides within cells. Thousands of intracellular peptides have been sequenced in plants, yeast, zebrafish, rodents, and in human cells and tissues. Relative levels of intracellular peptides undergo changes in human diseases and also when cells are stimulated, corroborating their biological function. Read More

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https://www.mdpi.com/2218-273X/9/4/150
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http://dx.doi.org/10.3390/biom9040150DOI Listing
April 2019
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QDPR homologues in Danio rerio regulate melanin synthesis, early gliogenesis, and glutamine homeostasis.

PLoS One 2019 17;14(4):e0215162. Epub 2019 Apr 17.

University Children's Hospital, Division of Child Neurology and Metabolic Diseases, Heidelberg, Germany.

Dihydropteridine reductase (QDPR) catalyzes the recycling of tetrahydrobiopterin (BH4), a cofactor in dopamine, serotonin, and phenylalanine metabolism. QDPR-deficient patients develop neurological symptoms including hypokinesia, truncal hypotonia, intellectual disability and seizures. The underlying pathomechanisms are poorly understood. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215162PLOS

Defining patterns of care in the management of patients with brain metastases in a large oncology centre: A single-centre retrospective audit of 236 cases.

Eur J Cancer Care (Engl) 2019 Apr 16:e13059. Epub 2019 Apr 16.

Department of Oncology and Radiotherapy, Nottingham University Hospitals NHS Trust, Nottingham, UK.

Aims: The role of selected treatments for brain metastases (BM) is well documented; however, the prevalence of these is not. We report on the patterns of care in the management of BM in a large oncology centre.

Materials And Methods: We retrospectively audited 236 cases of newly diagnosed BM from January 2016 to December 2017 by looking at 2 years of radiology reports and gathered data on primary site, survival, treatment received, palliative care input and brain metastases-related admissions. Read More

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http://dx.doi.org/10.1111/ecc.13059DOI Listing

Dysautonomia and hyponatraemia as harbingers of Guillain-Barre syndrome.

BMJ Case Rep 2019 Apr 15;12(4). Epub 2019 Apr 15.

Department of Critical Care, Jaslok Hospital and Research Centre, Mumbai, Maharashtra, India.

A 56-year-old woman with a medical history of hypertension presented to our hospital with back pain, abdominal pain, vomiting and elevated blood pressure. The laboratory parameters including evaluation for secondary hypertension were within normal ranges at the time of presentation. During her hospitalisation, fluctuations in her blood pressure and pulse were observed which were attributed to autonomic disturbances, the cause of which was unknown. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22692
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http://dx.doi.org/10.1136/bcr-2018-226925DOI Listing
April 2019
2 Reads

as a cause of acute CNS infection in an immune-competent girl undergoing repeated VP shunt surgeries.

BMJ Case Rep 2019 Apr 15;12(4). Epub 2019 Apr 15.

Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India.

We present the case of a 14-year-old immune-competent girl with ventriculoperitoneal shunt who was repeatedly hospitalised with meningeal signs despite repeated shunt revision surgeries. Eventually was isolated and the patient improved after specific treatment. is a rapidly growing, non-tuberculous mycobacterium (NTM). Read More

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http://dx.doi.org/10.1136/bcr-2018-226900DOI Listing

Drug-drug interactions between antiepileptics and cannabinoids.

Expert Opin Drug Metab Toxicol 2019 Apr 16:1-9. Epub 2019 Apr 16.

a Department of Pathophysiology , Medical University of Lublin , Lublin , Poland.

Introduction: About 40% of patients with epilepsy are associated with drug-resistant seizures, therefore there has been a continuous search for novel treatment approaches. In experimental studies, natural and synthetic cannabimimetic compounds alone or combined with antiepileptic drugs (AEDs) have been extensively studied and cannabidiol, a naturally occurring compound, has been involved in a number of clinical trials. Areas covered: The authors have performed a literature search (PubMed database up to December 2018) for studies evaluating interactions between AEDs and cannabinoid receptor ligands in experimental models of seizures. Read More

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https://www.tandfonline.com/doi/full/10.1080/17425255.2019.1
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http://dx.doi.org/10.1080/17425255.2019.1605355DOI Listing
April 2019
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[Conditioning psychosis - A new type of epileptic psychosis? A case report on a bidirectional connection between epilepsy and psychosis.]

Fortschr Neurol Psychiatr 2019 Apr 16. Epub 2019 Apr 16.

Introduction: Epilepsy and psychosis are not only closely related by clinical phenomena but presumably by causal factors, too. There is evidence that long-standing epileptic seizures can induce chronic psychosis. Whether chronic psychosis can cause epilepsy remains to be further investigated. Read More

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http://dx.doi.org/10.1055/a-0832-8557DOI Listing

Vitamin E modifies high-fat diet-induced reduction of seizure threshold in rats: Role of oxidative stress.

Physiol Behav 2019 Apr 13. Epub 2019 Apr 13.

Department of Clinical Pharmacy, Jordan University of Science and Technology, Irbid, Jordan.

There is increasing evidence that oxidative stress is a causal factor in different neurodegenerative disorders such as Alzheimer's disease and epilepsy. High-fat diet (HFD) has been shown to induce oxidative stress and neuronal damage that may increase susceptibility to seizures. The present study was undertaken to investigate the relationships between vitamin E, a potent antioxidant, HFD, and chemically induced seizures, using the PTZ seizure model in rats. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00319384183121
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http://dx.doi.org/10.1016/j.physbeh.2019.04.011DOI Listing
April 2019
3 Reads

Reduced Heat Generation During Magnetic Stimulation of Rat Sciatic Nerve Using Current Waveform Truncation.

IEEE Trans Neural Syst Rehabil Eng 2019 Apr 12. Epub 2019 Apr 12.

Introduction: Current truncating circuit designs used in some controllable pulse width transcranial magnetic stimulation systems can be adapted for use with the peripheral nervous system. Such a scaled-down stimulator produces neuromuscular activation using less stimulus energy than described in previous reports of sciatic nerve stimulation.

Methods: To evaluate the energy reductions possible with current truncation, we performed six in vivoexperiments in rats where the magnetic stimulating coil abutted the sciatic nerve. Read More

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http://dx.doi.org/10.1109/TNSRE.2019.2911054DOI Listing

Left Ventricular Assist Device Artifact in EEG.

Neurodiagn J 2019 Apr 16:1-9. Epub 2019 Apr 16.

b Department of Anesthesiology University of Florida College of Medicine , Gainesville , Florida.

Left ventricular assist devices are increasingly used as therapy for patients with severe congestive heart failure. These patients typically receive care in the intensive care unit when EEG monitoring is necessary. Identification of artifacts created by these devices is important for accurate EEG diagnosis, thus avoiding unnecessary therapies that may result in complications or require intubation of the patient. Read More

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https://www.tandfonline.com/doi/full/10.1080/21646821.2019.1
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http://dx.doi.org/10.1080/21646821.2019.1599649DOI Listing
April 2019
2 Reads

[Familial hypomagnesaemia with secondary hypocalcaemia as a cause of seizures in children].

Ugeskr Laeger 2019 Apr;181(15)

This case report presents a three-month-old girl, previously healthy, who was admitted to the hospital due to a cyanotic episode during breastfeeding. The episode was initially interpreted as aspiration. She had recurrent generalised seizures, and blood tests revealed hypomagnesaemia and hypocalcaemia. Read More

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April 2019
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[Fangji Dihuang Decoction formula syndrome and Fengyin Decoction formula syndrome:application in stroke and mental disorders].

Authors:
Xing-Jiang Xiong

Zhongguo Zhong Yao Za Zhi 2019 Feb;44(3):602-607

Guang'anmen Hospital, China Academy of Chinese Medical Sciences Beijing 100053, China.

Fangji Dihuang Decoction and Fengyin Decoction, which were firstly recorded in Synopsis of the Golden Chamber, could be used to treat stroke. However, both of these two decoctions are used infrequently. There is a clear pathogenesis of modern pathophysiology behind Fangji Dihuang Decoction syndrome and Fengyin Decoction syndrome, which can be interpreted by modern language of science. Read More

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http://dx.doi.org/10.19540/j.cnki.cjcmm.20181128.004DOI Listing
February 2019

Design, synthesis, in silico ADMET profile and GABA-A docking of novel phthalazines as potent anticonvulsants.

Arch Pharm (Weinheim) 2019 Apr 15:e1800387. Epub 2019 Apr 15.

Pharmaceutical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt.

A new series of 2-substituted-2,3-dihydrophthalazine-1,4-diones (2- 9) were designed and synthesized to evaluate their anticonvulsant activity. The neurotoxicity was assessed using the rotarod test. Molecular docking was performed for the synthesized compounds to assess their binding affinities as γ-aminobutyric acid A (GABA-A) receptor agonists as a possible mechanism of their anticonvulsant action, to rationalize their anticonvulsant activity in a qualitative way. Read More

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http://dx.doi.org/10.1002/ardp.201800387DOI Listing

Isolated nostril myoclonus: A novel ictal presentation in structural generalised epilepsy.

Authors:
Oliver R Marmoy

Clin Neurophysiol Pract 2019 14;4:76-80. Epub 2019 Mar 14.

Department of Clinical Neurophysiology, Portsmouth Hospitals NHS Trust, UK.

Introduction: Perioral myoclonus (POM) is a rare seizure manifestation which may present in either idiopathic or structural epilepsies. There has been little description of the rarer ictal manifestations in POM in generalised epilepsy. It is important during Electroencephalography (EEG) testing to carefully monitor clinical change during inter-ictal bursts, as this condition, demonstrated in this case, can exhibit extremely subtle seizure semiology which can allude typical clinical examination. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S2467981X193001
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http://dx.doi.org/10.1016/j.cnp.2019.02.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449652PMC
March 2019
1 Read

Correlation Between and Malocclusion in Rett Syndrome: A preliminary study.

Sultan Qaboos Univ Med J 2018 Nov 28;18(4):e489-e493. Epub 2019 Mar 28.

Department of Ear, Nose & Throat, University Hospital of Siena, Siena, Italy.

Objectives: Rett syndrome (RS) is a severe neurological developmental disorder characterised by stereotypical hand movements, epileptic seizures, craniofacial dysmorphism and digestive dysfunction. This study aimed to examine the correlation between the severity of malocclusion and in patients with RS.

Methods: This preliminary study was conducted at the Ear, Nose & Throat Clinic of the University Hospital of Siena, Siena, Italy, from January 2014 to December 2017. Read More

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https://journals.squ.edu.om/index.php/squmj/article/view/299
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http://dx.doi.org/10.18295/squmj.2018.18.04.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443277PMC
November 2018
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Isoniazid Poisoning: A Pediatric Simulation Case for Emergency Medicine Residents.

MedEdPORTAL 2016 Dec 9;12:10515. Epub 2016 Dec 9.

Assistant Residency Director, Department of Emergency Medicine, Emory University School of Medicine; Assistant Professor of Emergency Medicine, Emory University School of Medicine.

Introduction: Seizures in the setting of isoniazid (abbreviated INH, from isonocotinylhydrazide) toxicity can be intractable and persistent despite treatment with the usual status epilepticus (SE) medications. If not recognized in a timely fashion, SE can lead to significant morbidity and mortality. This simulation scenario instructs emergency medicine and pediatric residents and fellows in any year of training on the principles and management strategies of approaching a pediatric patient with SE due to INH toxicity. Read More

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https://www.mededportal.org/publication/10515
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http://dx.doi.org/10.15766/mep_2374-8265.10515DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440414PMC
December 2016
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Pediatric Emergency Medicine Simulation Curriculum: Hyponatremic Seizures.

MedEdPORTAL 2016 Nov 10;12:10498. Epub 2016 Nov 10.

Co-Director of Pediatric Emergency Medicine Simulation, Seattle Children's Hospital; Associate Professor of Emergency Medicine, University of Washington School of Medicine.

Introduction: Seizures are a common complaint in the pediatric emergency department. Effective care of this potentially life-threatening medical emergency requires the ability to stabilize the patient while simultaneously identifying and treating the underlying cause. This simulation-based curriculum involves the identification and management of a generalized seizure in a 4-month-old infant secondary to hyponatremia. Read More

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https://www.mededportal.org/publication/10498
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http://dx.doi.org/10.15766/mep_2374-8265.10498DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440407PMC
November 2016
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Epidemiology of Meningitis in Canadian Neonatal Intensive Care Units.

Pediatr Infect Dis J 2019 May;38(5):476-480

Maternal-Infant Care (MiCare) Research Centre, Mount Sinai Hospital.

Background: Meningitis is a serious disease that occurs more commonly in the neonatal period than in any other age group. Recent data from large national cohorts are needed to determine if the epidemiology of neonatal meningitis (NM) has changed.

Aim: To assess the rates, causative organisms, risk factors, temporal trends and short-term outcomes of NM in Canadian Neonatal Intensive Care Units (NICUs). Read More

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http://Insights.ovid.com/crossref?an=00006454-201905000-0000
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http://dx.doi.org/10.1097/INF.0000000000002247DOI Listing
May 2019
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Seizures and epilepsy following cranioplasty.

Seizure 2019 Apr 7;69:76. Epub 2019 Apr 7.

Department of Neurosurgery, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China. Electronic address:

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http://dx.doi.org/10.1016/j.seizure.2019.04.004DOI Listing

Highly-sensitive UHPLC-DAD method for simultaneous determination of two synergistically-acting antiepileptic drugs: Application to pharmaceutical tablets and human urine.

Biomed Chromatogr 2019 Apr 15:e4554. Epub 2019 Apr 15.

Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt.

A simple and highly sensitive Ultra High-performance Liquid Chromatographic -Diode array detection method (UHPLC-DAD) was developed and validated for the simultaneous estimation of levetiracetam (LEV) and lacosamide (LAC). It was clinically proven that the combination of LEV and LAC exhibits a synergistic effect against refractory seizures in mice, which was the motivation for the analysis of this binary mixture both in bulk and human urine samples. The binary mixture was resolved on a Hypersil BDS C analytical column, utilizing a mobile phase of 0. Read More

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http://dx.doi.org/10.1002/bmc.4554DOI Listing

Association of Closed-Loop Brain Stimulation Neurophysiological Features With Seizure Control Among Patients With Focal Epilepsy.

JAMA Neurol 2019 Apr 15. Epub 2019 Apr 15.

Brain Modulation Laboratory, Department of Neurological Surgery, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.

Importance: A bidirectional brain-computer interface that performs neurostimulation has been shown to improve seizure control in patients with refractory epilepsy, but the therapeutic mechanism is unknown.

Objective: To investigate whether electrographic effects of responsive neurostimulation (RNS), identified in electrocorticographic (ECOG) recordings from the device, are associated with patient outcomes.

Design, Setting, And Participants: Retrospective review of ECOG recordings and accompanying clinical meta-data from 11 consecutive patients with focal epilepsy who were implanted with a neurostimulation system between January 28, 2015, and June 6, 2017, with 22 to 112 weeks of follow-up. Read More

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http://dx.doi.org/10.1001/jamaneurol.2019.0658DOI Listing

EEG Findings in Infants With Neonatal Abstinence Syndrome Presenting With Clinical Seizures.

Front Pediatr 2019 29;7:111. Epub 2019 Mar 29.

Division of Neonatology, Department of Pediatrics, University of Kentucky, Lexington, KY, United States.

Neonatal abstinence syndrome (NAS) refers to a constellation of signs occurring in newborn infants who were exposed to opioids or opiates . These manifestations include poor feeding, gastrointestinal disorders, abnormal sleep patterns, and neurological signs such as jitteriness, tremors, and seizures (1, 2). Myoclonus, jitteriness, and tremors often may be interpreted as seizures and therefore treated as epileptic seizures. Read More

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http://dx.doi.org/10.3389/fped.2019.00111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449643PMC

Case Report: Levetiracetam causing acute liver failure complicating post-operative management in a neurosurgical patient.

F1000Res 2019 15;8:187. Epub 2019 Feb 15.

Department of Neurosurgery, Nobel Medical College and Teaching Hospital, Biratnagar, 0977, Nepal.

 Herein we report a rare case of acute liver failure due to levetiracetam, which has been considered to have an excellent safety profile with minimal hepatic side effects.  A 55-year-old male patient presenting with sudden onset dizziness, slurring of speech and headache was operated for posterior fossa cerebellar hematoma. His post-surgical period was complicated by development of icterus with elevation of liver enzymes. Read More

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https://f1000research.com/articles/8-187/v1
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http://dx.doi.org/10.12688/f1000research.18198.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446496PMC
February 2019
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Time of Day and a Ketogenic Diet Influence Susceptibility to SUDEP in Mice.

Front Neurol 2019 29;10:278. Epub 2019 Mar 29.

Department of Neurology, University of Iowa, Iowa City, IA, United States.

Sudden unexpected death in epilepsy (SUDEP) is a major cause of mortality in patients with drug-resistant epilepsy. Most SUDEP cases occur in bed at night and are preceded by a generalized tonic-clonic seizure (GTCS). Dravet syndrome (DS) is a severe childhood-onset epilepsy commonly caused by mutations in the gene. Read More

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https://www.frontiersin.org/article/10.3389/fneur.2019.00278
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http://dx.doi.org/10.3389/fneur.2019.00278DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449461PMC
March 2019
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Repetitive Transcranial Magnetic Stimulation in Youth With Treatment Resistant Major Depression.

Front Psychiatry 2019 29;10:170. Epub 2019 Mar 29.

Departments of Pediatrics and Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.

Major depressive disorder (MDD) is common in youth and treatment options are limited. We evaluated the effectiveness and safety of repetitive transcranial magnetic stimulation (rTMS) in adolescents and transitional aged youth with treatment resistant MDD. Thirty-two outpatients with moderate to severe, treatment-resistant MDD, aged 13-21 years underwent a three-week, open-label, single center trial of rTMS (ClinicalTrials. Read More

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https://www.frontiersin.org/article/10.3389/fpsyt.2019.00170
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http://dx.doi.org/10.3389/fpsyt.2019.00170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449763PMC
March 2019
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β-Mannosidosis in German Shepherd Dogs.

Vet Pathol 2019 Apr 14:300985819839239. Epub 2019 Apr 14.

6 Total Veterinary Services, Christchurch, New Zealand.

A neurological disease was investigated in 3 German Shepherd pups from the same litter that failed to grow normally, appeared stiff, were reluctant to move, and were deaf. They developed intermittent seizures and ataxia and had proprioceptive defects. Histopathology showed severe vacuolation of neurons, astrocytes in nervous tissue, renal tubular epithelial cells, and macrophages in nervous tissue, spleen, and liver. Read More

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http://dx.doi.org/10.1177/0300985819839239DOI Listing

Variations in Genes Related to Sleep Patterns in Children With Autism Spectrum Disorder.

Biol Res Nurs 2019 May;21(3):335-342

2 Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.

Background: Sleep disturbance is a frequent comorbidity in children with autism spectrum disorder (ASD), affecting an estimated 40-80% of cases. Previous reports have shown relationships between several circadian rhythm-related genes and sleep problems in ASD. The purpose of the present study was to relate variation in and around melatonin synthesis and suprachiasmatic nucleus genes to sleep problems in a large sample of children with ASD. Read More

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http://dx.doi.org/10.1177/1099800419843604DOI Listing
May 2019
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[Non-epileptic psychogenic seizures: a renewal approach of conversion disorders].

Rev Prat 2019 Feb;69(2):214-218

Centre hospitalier universitaire de Nancy, unité d'épileptologie, Nancy, France.

Non-epileptic psychogenic seizures: a renewal approach of conversion disorders. Psychogenic non-epileptic seizures (PNES) are characterized by a paroxystic modification of behaviour or consciousness that resemble to an epileptic seizure. They are classified as dissociative or somatoform disorders. Read More

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February 2019
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Hashimoto's Encephalopathy Presenting with Smoldering Limbic Encephalitis.

Intern Med 2019 15;58(8):1167-1172. Epub 2019 Apr 15.

Department of Neurology, Kyoto University Graduate School of Medicine, Japan.

Hashimoto's encephalopathy (HE) is a steroid-responsive autoimmune encephalopathy associated with Hashimoto thyroiditis. We herein report a case of HE manifesting "smoldering" limbic encephalitis with persisting symptoms and abnormalities on examinations. Although our patient experienced partial clinical remission after treatment, hippocampal hypermetabolism on [F] fluorodeoxyglucose positron emission tomography (FDG-PET) and subclinical seizures on video electroencephalography persisted. Read More

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http://dx.doi.org/10.2169/internalmedicine.1289-18DOI Listing
April 2019
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