5,223 results match your criteria Seizure Disorders in Pregnancy

Persistent knowledge gaps between 2005 and 2020 in women with epilepsy: Comparison of multicenter studies from Germany.

Seizure 2022 Jun 16;100:36-43. Epub 2022 Jun 16.

Epilepsy Center Frankfurt Rhine-Main, Center of Neurology and Neurosurgery, University Hospital Frankfurt, Goethe-University Frankfurt, Frankfurt am Main, Germany; LOEWE Center for Personalized Translational Epilepsy Research (CePTER), Goethe-University Frankfurt, Frankfurt am Main, Germany.

Objective: Epilepsy is a chronic condition that can affect patients of all ages. Women with epilepsy (WWE) require access to specific counseling and information regarding issues related to contraception, pregnancy, and hormonal effects on seizure control and bone mineral density. This study investigated the knowledge among WWE regarding their condition, and whether epilepsy-specific knowledge has improved over the last 15 years. Read More

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Dosage Optimization of Lamotrigine in Pregnancy: A Pharmacometric Approach using Modeling and Simulation.

J Clin Pharmacol 2022 Jun 23. Epub 2022 Jun 23.

Department of Pharmacy Practice, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Ooty, The Nilgiris, Tamil Nadu, 643001, India.

Lamotrigine is the most widely used anti-epileptic drug in pregnancy due to its low teratogenicity. However, there is an increased metabolism & clearance of Lamotrigine in pregnancy contributing to suboptimal drug therapy and poor disease control, prompting the need for pro-active dosage adjustments. The present study aimed to develop a pharmacometric model-based framework for recommending optimal dosage regimen for Lamotrigine in pregnancy. Read More

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Delivery of care, seizure control and medication adherence in women with epilepsy during pregnancy.

Seizure 2022 Jun 9;100:24-29. Epub 2022 Jun 9.

Department of Neurology, Institute of Neurological Sciences, NHS Greater Glasgow and Clyde, Langlands Drive, Glasgow, G51 4LB, UK, United Kingdom; School of Medicine, University of Glasgow, United Kingdom.

Purpose: To evaluate service access for women with epilepsy (WWE) during pregnancy; to determine seizure frequency and rates of adherence to anti-seizure medication (ASM).

Methods: Between June 2019-June 2020, pregnant WWE within NHS Greater Glasgow and Clyde health-board were identified from the National Obstetric Register. A manual review of electronic patient records was undertaken to ensure diagnostic accuracy, as well as determine contact with epilepsy services and documented seizures. Read More

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Seizure medication and planned pregnancy: balancing the risks and outcomes.

Expert Rev Neurother 2022 Jun 27:1-13. Epub 2022 Jun 27.

Complex Structure of Neurology, SS Annunziata Hospital, Taranto, Italy.

Introduction: The therapeutic management of women with epilepsy (WWE) of childbearing age can be complicated by the need to balance maternal/fetal risks related to seizure occurrence during gestation with the potential teratogenic risks related to the use of anti-seizure medications (ASMs).

Areas Covered: The authors review clinical evidence on seizure-related and ASM-related risks during pregnancy. Current regulatory indications are discussed, evaluating their impact on clinical practice, and ethical implications of pharmacological decisions are debated. Read More

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Iron Supplementation and Exercise During Pregnancy: Effects on Behavior and the Dopaminergic System.

Biol Trace Elem Res 2022 Jun 17. Epub 2022 Jun 17.

Faculdade de Ciências Aplicadas, Universidade Estadual de Campinas, Jardim Santa Luiza, Rua Pedro Zaccaria, Limeira, São Paulo, 1300CEP 13484350, Brazil.

Although it is known that regular physical activity is recommended as part of a healthy lifestyle, the number of data concerning efficacy of exercise and your relationship with a demand for iron during pregnancy is limited. The purpose of this study was to evaluate the relationship between iron supplementation and exercise during pregnancy on the behavior of rats. Molecular variables dopamine transporter (DAT) and dopamine receptor (D2) related to the locomotor behavior in response to the exercise and the iron supplemented diet were investigated. Read More

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Treatment and care of women with epilepsy before, during, and after pregnancy: a practical guide.

Ther Adv Neurol Disord 2022 11;15:17562864221101687. Epub 2022 Jun 11.

Department of Neurology, Christian Doppler University Hospital, Paracelsus Medical University and Centre for Cognitive Neuroscience, Member of the ERN EpiCARE, Ignaz-Harrer-Str. 79, 5020 Salzburg, Austria.

Women with epilepsy (WWE) wishing for a child represent a highly relevant subgroup of epilepsy patients. The treating epileptologist needs to delineate the epilepsy syndrome and choose the appropriate anti-seizure medication (ASM) considering the main goal of seizure freedom, teratogenic risks, changes in drug metabolism during pregnancy and postpartum, demanding for up-titration during and down-titration after pregnancy. Folic acid or vitamin K supplements and breastfeeding are also discussed in this review. Read More

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Aberrant induction of p19Arf-mediated cellular senescence contributes to neurodevelopmental defects.

PLoS Biol 2022 06 14;20(6):e3001664. Epub 2022 Jun 14.

Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Illkirch, France.

Valproic acid (VPA) is a widely prescribed drug to treat epilepsy, bipolar disorder, and migraine. If taken during pregnancy, however, exposure to the developing embryo can cause birth defects, cognitive impairment, and autism spectrum disorder. How VPA causes these developmental defects remains unknown. Read More

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Directive clinique n427 : Suppléments d'acide folique et multivitamines en prévention des anomalies congénitales sensibles à l'acide folique.

J Obstet Gynaecol Can 2022 Jun;44(6):720-732.e1

Toronto, Ont.

Objectif: Offrir des recommandations à jour sur l'utilisation de multivitamines et de suppléments d'acide folique avant la conception pour la prévention primaire et secondaire (récidive) des anomalies du tube neural et des autres anomalies congénitales sensibles à l'acide folique.

Population Cible: Les femmes de 12 à 45 ans qui pourraient devenir enceintes doivent être informées des risques importants d'anomalies congénitales en l'absence d'une supplémentation adéquate en acide folique avant la conception et pendant le premier trimestre.

Options: La supplémentation optimale en acide folique est complexe et repose sur divers facteurs tels que la dose, le type de suppléments, la biodisponibilité du folate dans l'alimentation, le moment du début de la supplémentation ainsi que sur les facteurs métaboliques et génétiques. Read More

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Guideline No. 427: Folic Acid and Multivitamin Supplementation for Prevention of Folic Acid-Sensitive Congenital Anomalies.

J Obstet Gynaecol Can 2022 Jun;44(6):707-719.e1

Toronto, ON.

Objective: To provide updated guidance on pre-conception folic acid and multivitamin supplementation for primary and secondary (recurrence) prevention of neural tube defects and other folate-sensitive congenital anomalies.

Target Population: Women aged 12-45 years who could become pregnant should be aware of the risk of serious birth defects without adequate pre-conception and first-trimester folic acid supplementation.

Options: Optimizing folic acid supplementation is complex and depends on factors including dosage; type of supplement; bioavailability of folate from food, timing of initiating supplementation; and metabolic and genetic factors. Read More

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Syncope in a pregnant woman with repaired Tetralogy of Fallot: a case report.

Eur Heart J Case Rep 2022 Jun 24;6(6):ytac209. Epub 2022 May 24.

Nork-Marash Medical Center, Armenak Armenakyan St. 13, 0047 Yerevan, Armenia.

Background: Tetralogy of Fallot (TOF) is one of the most widespread cyanotic congenital heart disease (CHD), which can be successfully repaired in the neonatal period. However, residual problems and the surgical technique itself can create a favourable basis for arrhythmias and conduction abnormalities in these patients. Sometimes, these arrhythmias may worsen during pregnancy and require urgent intervention. Read More

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Preeclampsia diagnosis and management.

Best Pract Res Clin Anaesthesiol 2022 May 10;36(1):107-121. Epub 2022 Feb 10.

Columbia University Irving Medical Center, United States of America; Columbia University, United States of America. Electronic address:

Preeclampsia is a severe manifestation of maternal hypertensive disease affecting 2-8% of pregnancies. The disease places women at risk of women at risk of life-threatening events, including cerebral hemorrhage, pulmonary edema, acute kidney injury, hepatic failure or rupture, disseminated intravascular coagulation, eclampsia, and placental abruption. In addition to the maternal disease burden, increased fetal morbidity and mortality occurs due to iatrogenic preterm delivery, fetal growth restriction, and placental abruption. Read More

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A Multicenter Study of Adherence to Best Practices and Application of Epilepsy Quality Metrics in a Pediatric Telemedicine Encounter.

J Child Neurol 2022 Jun 3:8830738221099730. Epub 2022 Jun 3.

2650Nationwide Children's Hospital, Center for Clinical Excellence, The Ohio State University College of Medicine, Division of Neurology.

To assess Epilepsy Quality Metrics (EQM) and guideline implementation in new pediatric patients seen in telemedicine. Multicenter, cross sectional, retrospective analysis. Patients were similar across 3 centers for age, gender, and insurance type. Read More

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Cutaneous Hypersensitivity Reaction After Phenytoin Therapy in a Neonate: A Case Report and Review of Literature Elucidating the Potential Pharmacological Plausibility and Preventive Strategies.

Curr Drug Saf 2022 May 31. Epub 2022 May 31.

Department of Pharmacology, SRM Medical College Hospital and Research Centre, Kattankulathur, TamilNadu, India.

Background: Drug-induced hypersensitivity reaction is a potentially life-threatening condition reported among patients of different age groups. Phenytoin is a prototypic drug prescribed for the treatment of a variety of seizure disorders. Allergic reaction to phenytoin therapy in a newborn is relatively a rare clinical manifestation that is not frequently reported. Read More

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Comprehensive strategy required to eliminate valproate prescribing in pregnancy.

BMJ 2022 05 31;377:o1339. Epub 2022 May 31.

University of Auckland, Waikato Clinical Campus, Hamilton, New Zealand.

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Association of Prenatal Exposure to Antiseizure Medication With Risk of Autism and Intellectual Disability.

JAMA Neurol 2022 May 31. Epub 2022 May 31.

National Centre for Register-Based Research, Department of Economics and Business Economics, Aarhus School of Business and Social Services, Aarhus University, Aarhus, Denmark.

Importance: Women with epilepsy frequently need antiseizure medication (ASM) to prevent seizures in pregnancy. Risk of neurodevelopmental disorders after prenatal exposure to AMSs is uncertain.

Objective: To determine whether children exposed prenatally to ASMs in monotherapy and duotherapy have increased risk of neurodevelopmental disorders. Read More

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Neurological factors and Cesarean section in Australian women with epilepsy.

Epilepsy Behav 2022 Jul 27;132:108740. Epub 2022 May 27.

Royal Brisbane and Women's Hospital and School of Medicine and Biomedical Science, University of Queensland, Brisbane, QLD 4027, Australia.

Objectives: To analyze the records of the pregnancies of 2283 Australian women with epilepsy in the Australian Register of Antiepileptic Drugs in Pregnancy database to identify neurological factors relevant to the Cesarean sections carried out in these pregnancies.

Results: The Cesarean section rate in Australian women overall increased by an average of 0.59% annually over 20 years, from 26. Read More

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Transcriptome meta-analysis of valproic acid exposure in human embryonic stem cells.

Eur Neuropsychopharmacol 2022 Jul 27;60:76-88. Epub 2022 May 27.

Post-Graduation Program in Genetics and Molecular Biology, Genetics Department, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil; Laboratory of Genomic Medicine, Center of Experimental Research, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Brazil; National Institute of Medical Population Genetics (INAGEMP), Porto Alegre, Brazil. Electronic address:

Valproic acid (VPA) is a widely used antiepileptic drug not recommended in pregnancy because it is teratogenic. Many assays have assessed the impact of the VPA exposure on the transcriptome of human embryonic stem-cells (hESC), but the molecular perturbations that VPA exerts in neurodevelopment are not completely understood. This study aimed to perform a transcriptome meta-analysis of VPA-exposed hESC to elucidate the main biological mechanisms altered by VPA effects on the gene expression. Read More

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Monitoring of lamotrigine concentrations in mothers, colostrum, and breastfed newborns during the early postpartum period.

Biomed Pharmacother 2022 Jul 24;151:113167. Epub 2022 May 24.

Department of Clinical Pharmacology, Faculty of Medicine, University of Ostrava, Syllabova 19, 703 00 Ostrava, Czech Republic; Department of Clinical Pharmacology, Institute of Laboratory Medicine, University Hospital Ostrava, 17. listopadu 1790, 700 30 Ostrava, Czech Republic.

Objective: To analyse the concentrations of lamotrigine in maternal serum, colostrum, and serum of breastfed newborns, and to evaluate the effect of comedication with enzyme-inducing antiseizure medication and valproic acid.

Methods: This cohort study collected data from 158 women and 143 breastfed newborns. Maternal serum, milk (i. Read More

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Preeclampsia and Related Problems.

Indian J Crit Care Med 2021 Dec;25(Suppl 3):S261-S266

Department of Critical Care Medicine, Jupiter Hospital, Mumbai, Maharashtra, India.

Hypertensive disorders of pregnancy can be classified as chronic hypertension (present before pregnancy), gestational hypertension (onset after 20 weeks of pregnancy), and preeclampsia (onset after 20 weeks of pregnancy, along with proteinuria and other organ dysfunction). Preeclampsia and related disorders are a major cause of maternal and fetal morbidity and mortality. Preeclampsia is believed to result from an angiogenic imbalance in the placenta circulation. Read More

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December 2021

Spectrum of Neurological Illnesses in Pregnancy - An Observational Study from a Tertiary Care Centre of Eastern India.

J Assoc Physicians India 2022 May;70(5):11-12

Professor, Bangur Institute of Neurosciences IPGMER & SSKM Hospital Annex-1, , Kolkata, West Bengal; * Corresponding Author.

Introduction: Neurological disorders in pregnancy may be observed in patients with a pre-existing neurological disorder; patients developing a primary neurological disorder during the course of pregnancy or puerperium; and in patients with primary medical disorders presenting with neurological manifestations.

Objectives: The objectives of the study were to find out the magnitude of neurological disorders in pregnancy in a tertiary care hospital along with assessment of proportion of women with particular disorders among total number of neurological disorders during the course of pregnancy or puerperium (6 weeks after child birth) and also to elicit the effect of neurological disorders on pregnancy outcome, if any.

Methods: A prospective observational longitudinal study was carried out in a tertiary care centre of Eastern India from July 2018 to June 2020 including all pregnant women attending the department of Obstetrics and Gynaecology. Read More

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Adverse fetal and neonatal outcomes following in-utero exposure to oxcarbazepine: A systematic review and meta-analysis.

Br J Clin Pharmacol 2022 May 19. Epub 2022 May 19.

Department of Pathology, King Edward Medical University, Lahore, Pakistan.

Aim: This systematic review aims to assess the safety profile of oxcarbazepine during pregnancy.

Methods: Observational studies that included women who took oxcarbazepine anytime during pregnancy were included in our systematic review. The review did not include non-English articles, reviews, meta-analyses, case reports and animal studies. Read More

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Folic Acid and Risk of Preterm Birth, Preeclampsia and Fetal Growth Restriction Among Women With Epilepsy: A Prospective Cohort Study.

Neurology 2022 May 16. Epub 2022 May 16.

Department of Clinical Medicine, University of Bergen, Norway.

Background And Objectives: Women with epilepsy treated with antiseizure medication (ASM) have increased risk of pregnancy complications including preterm birth, fetal growth restriction and preeclampsia. We aimed to investigate whether folic acid supplementation is associated with these pregnancy complications in women with epilepsy using ASM.

Methods: Singleton pregnancies in the prospective Norwegian Mother and Child Cohort Study (MoBa) (1999-2008) were included. Read More

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The Rate of and Factors Associated with Delivery by Caesarean Section among Women with Epilepsy: Time Trend in a Single-Centre Cohort in Mazovia, Poland.

J Clin Med 2022 May 6;11(9). Epub 2022 May 6.

Centre for Postgraduate Medical Education, Department of Neurology and Epileptology, 00-416 Warsaw, Poland.

Data from literature suggest that the rate of caesarean section (CS) in women with epilepsy (WWE) is higher than in the general population. In Poland, there is neither a national registry nor another data set to access the outcome of pregnancy in WWE. Therefore, we address this gap by prospectively studying CS rates among 1021 WWE pregnancies at a single centre, their trends over time, and factors increasing the likelihood of the CS. Read More

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Maternal Serotonergic Antidepressant Use in Pregnancy and Risk of Seizures in Children.

Neurology 2022 May 11. Epub 2022 May 11.

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

Objective: To evaluate whether children born to women who use serotonergic antidepressants during pregnancy have higher risk of neonatal seizures and epilepsy.

Methods: We used Swedish register-based data to examine associations between maternal-reported use of selective-serotonin reuptake inhibitor (SSRI) and selective serotonin-norepinephrine reuptake inhibitors (SNRI) in pregnancy and diagnosis of neonatal seizures and/or epilepsy in over 1.2 million children. Read More

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The role of Australian clinical quality registries in pregnancy care: A scoping review.

Aust N Z J Obstet Gynaecol 2022 May 11. Epub 2022 May 11.

Department of Obstetrics and Gynaecology, The University of Melbourne, Parkville, Victoria, Australia.

Background: Pregnancy represents a time of increased morbidity and mortality for women and their infants. Clinical quality registries (CQRs) collect, analyse and report key healthcare quality indicators for patient cohorts to improve patient care. There are limited data regarding existing CQRs in pregnancy. Read More

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