4,462 results match your criteria Seizure Disorders in Pregnancy


European Stroke Organization guideline for the diagnosis and treatment of cerebral venous thrombosis - Endorsed by the European Academy of Neurology.

Eur Stroke J 2017 Sep 21;2(3):195-221. Epub 2017 Jul 21.

Department of Neurology, Academic Medical Center, Amsterdam, the Netherlands.

The current proposal for cerebral venous thrombosis guideline followed the Grading of Recommendations, Assessment, Development, and Evaluation system, formulating relevant diagnostic and treatment questions, performing systematic reviews of all available evidence and writing recommendations and deciding on their strength on an explicit and transparent manner, based on the quality of available scientific evidence. The guideline addresses both diagnostic and therapeutic topics. We suggest using magnetic resonance or computed tomography angiography for confirming the diagnosis of cerebral venous thrombosis and not screening patients with cerebral venous thrombosis routinely for thrombophilia or cancer. Read More

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http://journals.sagepub.com/doi/10.1177/2396987317719364
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http://dx.doi.org/10.1177/2396987317719364DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454824PMC
September 2017
1 Read

Children Born to Mothers with Rash During Zika Virus Epidemic in Brazil: First 18 Months of Life.

J Trop Pediatr 2019 Apr 21. Epub 2019 Apr 21.

Faculdade de Medicina, Universidade Federal Fluminense, RJ 24.033-900, Brazil.

Objective: To better understand the clinical spectrum and course of congenital Zika syndrome (CZS) during the first 18 months of life of children whose mothers had rash during pregnancy.

Methods: This longitudinal observational study evaluated the clinical progress from birth until 18 months of life of children of mothers who developed rash during or up to 3 months before gestation. Maternal rash occurred from November 2015 to May 2017. Read More

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https://academic.oup.com/tropej/advance-article/doi/10.1093/
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http://dx.doi.org/10.1093/tropej/fmz019DOI Listing
April 2019
1 Read

Teratogenic potential of third-generation antiepileptic drugs: Current status and research needs.

Pharmacol Rep 2019 Jan 31;71(3):491-502. Epub 2019 Jan 31.

Neurobiology Lab, Department of Zoology, University of Allahabad, Allahabad, India. Electronic address:

The aim of this review was to scrutinize the current literature available on teratogenic safety of third-generation antiepileptic drugs (TGAEDs) considering their clinical implications and to highlight for further research need in the interest of the diseased population in general and women with epilepsy in particular. For evaluation of the teratogenic potential of TGAEDs, this review summarized the existing information on controlled clinical trials conducted by the pharmaceutical companies, case reports, scholarly articles (prospective and retrospective studies), and experimental tests carried out so far. Firstly, clinical reports have reviewed on each drug followed by non-clinical studies reported hitherto. Read More

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http://dx.doi.org/10.1016/j.pharep.2019.01.011DOI Listing
January 2019

The effects of valproic acid on early pregnancy human placentas: Pilot ex vivo analysis in cultured placental villi.

Epilepsia 2019 Apr 13. Epub 2019 Apr 13.

Institute for Drug Research, School of Pharmacy, Hebrew University of Jerusalem, Jerusalem, Israel.

Valproic acid is an established structural and neurodevelopmental teratogen. Recently, we demonstrated that valproate alters the barrier function of perfused term human placentas. Here, we conducted a pilot study to evaluate the effects of subchronic valproate exposure on carrier expression in cultured placental villous explants from early human pregnancies. Read More

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http://dx.doi.org/10.1111/epi.14721DOI Listing
April 2019
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Maternal epilepsy and behavioral development of the child: Family factors do matter.

Epilepsy Behav 2019 Apr 8;94:222-232. Epub 2019 Apr 8.

Stichting Epilepsie Instellingen Nederland (SEIN), Heemstede, the Netherlands; Research Institute of Child Development and Education, University of Amsterdam, the Netherlands. Electronic address:

Purpose: The purpose of the study was to examine whether mothers with epilepsy experience family problems and to investigate the possible mediating role of distinct family factors in the relationship between maternal epilepsy and child behavioral problems, in which it is also investigated whether more proximal family factors mediate the more distal family factors.

Methods: In an observational study, with children identified from the European Registry of Antiepileptic Drugs and Pregnancy database in the Netherlands (EURAP-NL), parents completed questionnaires on maternal epilepsy, family factors (proximal, distal, contextual, global), and child behavior. Hierarchical multilevel regression analyses were performed to examine the relative contribution of epilepsy-related and family factors on child internalizing and externalizing problems. Read More

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http://dx.doi.org/10.1016/j.yebeh.2019.03.030DOI Listing
April 2019
1 Read

Valproic Acid Leads New Neurons Down the Wrong Path.

Authors:
Steve C Danzer

Epilepsy Curr 2019 Mar-Apr;19(2):132-133

Ectopic Neurogenesis Induced by Prenatal Antiepileptic Drug Exposure Augments Seizure Susceptibility in Adult Mice Sakai A, Matsuda T, Doi H, Nagaishi Y, Kato K, Nakashima K. Proc Natl Acad Sci U S A. 2018;115(16):4270-4275. Read More

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http://dx.doi.org/10.1177/1535759719835366DOI Listing
April 2019
6 Reads

Asymmetric neonatal spasms as an early sign of brain malformation potentially caused by regular light alcohol consumption during the first 22 weeks of pregnancy, a clinical case report.

Dev Period Med 2019 ;23(1):15-20

NICU of Lviv City Children's Hospital.

Objective: Introduction: Epileptic spasms are seizures usually associated with a severe developmental epilepsy syndrome with onset in the first year of life, peaking between 3 and 10 months of age [12]. A variety of disorders can cause epileptic spasms, with the etiology driving management, prognosis, and overall outcome. Preexisting brain damage has been demonstrated in 60% to 90% of the cases reflecting pre-, peri-, or postnatal brain injury that may usually be determined by history and clinical neurologic examination. Read More

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January 2019
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Treatment of Women With Epilepsy.

Authors:
Mona Sazgar

Continuum (Minneap Minn) 2019 Apr;25(2):408-430

Purpose Of Review: This article provides the latest information to guide practitioners in counseling and treating women with epilepsy.

Recent Findings: There is an increasing body of literature on the multidirectional effects of sex hormones on seizure frequency and severity and of seizures altering areas of the brain involved in neuroendocrine function. Ongoing pregnancy outcome data from pregnancy registries and meta-analysis of observational studies have provided key information on the safety of using antiseizure medications during pregnancy and the risk to the fetus. Read More

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http://dx.doi.org/10.1212/CON.0000000000000713DOI Listing
April 2019
5 Reads

Clinical and neurodevelopmental features in children with cerebral palsy and probable congenital Zika.

Brain Dev 2019 Mar 23. Epub 2019 Mar 23.

Federal University of Bahia, Salvador, Bahia, Brazil.

Objective: To describe the neurological and neurodevelopmental features at 1 year of age in children with cerebral palsy (CP) related to probable congenital Zika (CZ), followed in a referral neurorehabilitation hospital.

Methods: Data on 82 children with CP associated with probable CZ, who consecutively attended the neurodevelopmental and neurological assessment around one year of age, were collected. For neurodevelopmental evaluation, Bayley-III Scales of Infant and Toddler Development was used. Read More

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http://dx.doi.org/10.1016/j.braindev.2019.03.005DOI Listing
March 2019
2 Reads

Ontogeny and programming of the fetal temporal cortical endocannabinoid system by moderate maternal nutrient reduction in baboons (Papio spp.).

Physiol Rep 2019 Mar;7(6):e14024

Department of Obstetrics and Gynecology, Texas Tech University Health sciences Center at the Permian Basin, Odessa, Texas.

Poor nutrition during pregnancy is a worldwide public health problem. Maternal nutrient reduction (MNR) is associated with maternal and fetal stress and a sex-dependent decrease in nonhuman primate (NHP) cognitive performance. Early life stress potentiates epileptogenesis in a sex-specific manner, and temporal lobe (TL) epilepsy is associated with neurocognitive disorders. Read More

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http://dx.doi.org/10.14814/phy2.14024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434170PMC
March 2019
1 Read

Neuroprotective effect of astaxanthin on newborn rats exposed to prenatal maternal seizures.

Brain Res Bull 2019 Mar 22;148:63-69. Epub 2019 Mar 22.

Key Laboratory of Neurology of Hebei Province, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050000, China. Electronic address:

Maternal epilepsy during pregnancy is associated with an increased incidence of brain damage and cognitive deficits in offspring. Oxidative stress is believed to play a critical role in this process. Astaxanthin, a natural carotenoid and dietary supplement, possesses potent antioxidant properties. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.03.009DOI Listing
March 2019
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Pregnancy and Childbirth Experiences of Women with Epilepsy: A Phenomenological Approach.

Authors:
Joung Woo Joung

Asian Nurs Res (Korean Soc Nurs Sci) 2019 Mar 11. Epub 2019 Mar 11.

KyungpookNational University, 41944 680 Gukchatbosang-ro, Jung-gu, Daegu, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.anr.2019.02.005DOI Listing
March 2019
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Etiology and Outcomes of Thrombotic Microangiopathies.

Clin J Am Soc Nephrol 2019 Apr 12;14(4):557-566. Epub 2019 Mar 12.

Service de Néphrologie-hypertension, Dialyses, Transplantation Rénale, Hôpital Bretonneau et hôpital Clocheville,

Background And Objectives: Thrombotic microangiopathies constitute a diagnostic and therapeutic challenge. Secondary thrombotic microangiopathies are less characterized than primary thrombotic microangiopathies (thrombotic thrombocytopenic purpura and atypical hemolytic and uremic syndrome). The relative frequencies and outcomes of secondary and primary thrombotic microangiopathies are unknown. Read More

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http://dx.doi.org/10.2215/CJN.11470918DOI Listing
April 2019
3 Reads

Management of epilepsy in women.

Lancet Neurol 2019 May 8;18(5):481-491. Epub 2019 Mar 8.

Scottish Epilepsy Initiative, Glasgow, UK.

Epilepsy is a common neurological condition in women worldwide. Hormonal changes occurring throughout a woman's life can influence and be influenced by seizure mechanisms and antiepileptic drugs, presenting unique management challenges. Effective contraception is particularly important for women with epilepsy of childbearing potential because of antiepileptic drug-related teratogenicity and hormonal interactions; although studies reveal many women do not receive contraceptive and preconceptual counselling. Read More

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http://dx.doi.org/10.1016/S1474-4422(18)30495-2DOI Listing
May 2019
6 Reads

Examination of the prescription of antiepileptic drugs to prenatal and postpartum women in Japan from a health administrative database.

Pharmacoepidemiol Drug Saf 2019 Mar 10. Epub 2019 Mar 10.

Laboratory of Clinical Pharmacy, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.

Purpose: To evaluate the prevalence and patterns of prescriptions of antiepileptic drugs (AEDs) to prenatal and postpartum women in Japan using a large administrative database.

Methods: The dates of pregnancy onset and delivery were estimated using published algorithms and infant birth months. The prevalence of prescribed AEDs, the maximum dose of some AEDs, and the frequency of potential combination therapy with AEDs were evaluated for the 180 days before pregnancy onset, during pregnancy, and at 180-day postpartum. Read More

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http://doi.wiley.com/10.1002/pds.4749
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http://dx.doi.org/10.1002/pds.4749DOI Listing
March 2019
5 Reads

Valproate MHRA Guidance: Limitations and Opportunities.

Front Neurol 2019 20;10:139. Epub 2019 Feb 20.

Cornwall Partnership NHS Foundation Trust, Threemilestone Industrial Estate, Truro, United Kingdom.

Recent publication of the Medicines and Healthcare products Regulatory Agency (MHRA) in the United Kingdom has strengthened the regulatory measures for valproate medicines. It highlights the importance of making women of childbearing age with epilepsy aware of the teratogenic risks of valproate and encourages the withdrawal of it from those currently prescribed. While a significant directive, it raises concerns of not having considered the impact on special populations such as women with Intellectual Disability (ID). Read More

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http://dx.doi.org/10.3389/fneur.2019.00139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391862PMC
February 2019
1 Read

Developmental outcomes at age four following maternal antiepileptic drug use.

Epilepsy Behav 2019 Mar 1;93:73-79. Epub 2019 Mar 1.

School of Pharmacy, University of Otago, Dunedin, New Zealand.

We investigated whether prenatal antiepileptic drug (AED) exposure was associated with adverse outcomes in the Before School Check (B4SC) assessments, particularly the assessments measuring neurodevelopment. Children exposed to AEDs were identified by linking women dispensed AEDs in the Pharmaceutical Collection to births recorded on the National Minimum Dataset (NMDS). Multinomial logistic regression was used to estimate adjusted risk ratios (aRRs) and 95% confidence intervals (CIs) for outcomes of the parent-completed Parental Evaluation of Developmental Status (PEDS) questionnaire and Strengths and Difficulties Questionnaire (SDQ), after adjusting for gender, ethnicity, and socioeconomic deprivation. Read More

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http://dx.doi.org/10.1016/j.yebeh.2019.01.018DOI Listing
March 2019
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Level of empowerment and decision-making style of women with epilepsy in childbirth age.

Epilepsy Behav 2019 Mar 1;93:32-37. Epub 2019 Mar 1.

European Institute of Oncology, Department of Psychoncology, University of Milan, Italy.

Objectives: This research investigates level of empowerment, decisional skills, and the perceived relationship with the clinician, of women in childbirth age, also in relationship with clinical variables such as epilepsy type, seizure frequency, therapy, and pregnancy status. In particular, as concerning therapy, we were interested in women who take valproic acid (VPA), for its specific balance of risks and benefits, especially in pregnant women.

Methods: The sample is composed of 60 women with epilepsy (6 were excluded), who underwent a standardized clinical protocol for assessment of level of empowerment, decisional skills, and of their judgment about how they feel to be involved by their clinician in medical decision making. Read More

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http://dx.doi.org/10.1016/j.yebeh.2019.01.037DOI Listing
March 2019
1 Read
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The potential contribution of impaired brain glucose metabolism to congenital Zika syndrome.

J Anat 2019 Feb 21. Epub 2019 Feb 21.

Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.

The Zika virus (ZIKV) became a major worldwide public concern in 2015 due to the congenital syndrome which presents the highest risk during the first trimester of pregnancy and includes microcephaly and eye malformations. Several cellular, genetic and molecular studies have shown alterations in metabolic pathways, endoplasmic reticulum (ER) stress, immunity and dysregulation of RNA and energy metabolism both in vivo and in vitro. Here we summarise the main metabolic complications, with a particular focus on the possibility that brain energy metabolism is altered following ZIKV infection, contributing to developmental abnormalities. Read More

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http://dx.doi.org/10.1111/joa.12959DOI Listing
February 2019
1 Read
2.097 Impact Factor

Associations between use of macrolide antibiotics during pregnancy and adverse child outcomes: A systematic review and meta-analysis.

PLoS One 2019 19;14(2):e0212212. Epub 2019 Feb 19.

Population, Policy and Practice Programme, Great Ormond Street Institute of Child Health, University College London, London, United Kingdom.

Background: Evidence on adverse effects of maternal macrolide use during pregnancy is inconsistent. We conducted a systematic review and meta-analysis to investigate the association between macrolide use during pregnancy and adverse fetal and child outcomes.

Methods And Findings: We included observational studies and randomised controlled trials (RCTs) that recorded macrolide use during pregnancy and child outcomes. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212212PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380581PMC
February 2019
2 Reads

Collaboration of Care for Women with Epilepsy in their Reproductive Years.

J Womens Health (Larchmt) 2019 Mar 15;28(3):339-345. Epub 2019 Feb 15.

2 New York University School of Medicine, New York, New York.

Over half a million women of childbearing age have epilepsy, many of which will require family planning care at some point in their reproductive years. Matters relating to contraception, pregnancy, fertility, and sexual functioning are all impacted to varying degrees by the use of antiepileptic drugs (AEDs) to treat epilepsy and require active management by a woman's neurologist. It is important that a woman's obstetrician/gynecologist (OBGYN) and internist are aware of the way in which their care may be related to her epilepsy care and how this can be successfully comanaged with her neurologist. Read More

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https://www.liebertpub.com/doi/10.1089/jwh.2018.7506
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http://dx.doi.org/10.1089/jwh.2018.7506DOI Listing
March 2019
19 Reads

Potential public health benefits from cat eradications on islands.

PLoS Negl Trop Dis 2019 02 14;13(2):e0007040. Epub 2019 Feb 14.

Department of Ecology and Evolutionary Biology, University of California Santa Cruz, Santa Cruz, California, United States of America.

Cats (Felis catus) are reservoirs of several pathogens that affect humans, including Toxoplasma gondii. Infection of pregnant women with T. gondii can cause ocular and neurological lesions in newborns, and congenital toxoplasmosis has been associated with schizophrenia, epilepsy, movement disorders, and Alzheimer's disease. Read More

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http://dx.plos.org/10.1371/journal.pntd.0007040
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http://dx.doi.org/10.1371/journal.pntd.0007040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6392314PMC
February 2019
13 Reads

Treatment of Juvenile Myoclonic Epilepsy in Patients of Child-Bearing Potential.

CNS Drugs 2019 Mar;33(3):195-208

Epilepsy Unit, Hôpital Gui de Chauliac, 80 Avenue Fliche, 34295, Montpellier Cedex 05, France.

Juvenile myoclonic epilepsy (JME) is both a frequent and a very characteristic epileptic syndrome with female preponderance. Treatment of JME in women of childbearing potential must consider multiple factors such as desire for pregnancy, use of contraception, seizure control and previously used antiepileptic drugs (AEDs). Approximately 85% of cases are well controlled with valproate, which remains the reference AED in JME but is nowadays considered unsafe for the expecting mother and her fetus. Read More

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http://link.springer.com/10.1007/s40263-018-00602-2
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http://dx.doi.org/10.1007/s40263-018-00602-2DOI Listing
March 2019
14 Reads

Trial of labor after cesarean section in risk pregnancies: A population-based cohort study.

Acta Obstet Gynecol Scand 2019 Feb 8. Epub 2019 Feb 8.

Department of Clinical Science, University of Bergen, Bergen, Norway.

Introduction: In most pregnancies after a cesarean section, a trial of labor is an option. The objective of the study was to explore trial of labor and its failure in pregnancies with medical risk conditions, in a population with a high trial of labor rate.

Material And Methods: In a cohort study (n = 57 109), using data from the Medical Birth Registry of Norway 1989-2014, women with a second delivery after a first pregnancy cesarean section were included. Read More

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http://dx.doi.org/10.1111/aogs.13565DOI Listing
February 2019
4 Reads

Neurological diseases in pregnancy.

Curr Opin Obstet Gynecol 2019 Apr;31(2):97-109

Department of Obstetrics and Gynecology, University of Rochester Medical Center, Rochester, New York, USA.

Purpose Of Review: To summarize recent research findings and current concepts related to care of neurologic diseases in pregnancy and the risks of pregnancy to the mother-infant dyad. Recent publications related to best practices for neurologic care, risks of pregnancy, rate of relapse during and after pregnancy, as well as medication safety in pregnancy and lactation for more commonly used neurologic medications are reviewed.

Recent Findings: Data continues to grow that women with neurologic conditions can experience pregnancy with minimal risks. Read More

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http://dx.doi.org/10.1097/GCO.0000000000000525DOI Listing
April 2019
12 Reads

Prenatal detection of right aortic arch.

Arch Gynecol Obstet 2019 Apr 31;299(4):933-938. Epub 2019 Jan 31.

Department of Gynecology and Obstetrics, Division of Feto-Maternal Medicine, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.

Purpose: To examine an unselective population of fetuses with right aortic arch (RAA) and suggest perinatal management. Second, to evaluate the importance and possible implication of fetal MRI in those cases.

Methods: Retrospective study of 36 patients with RAA diagnosed prenatally between 2006 and 2017 in a tertiary referral center. Read More

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http://dx.doi.org/10.1007/s00404-019-05056-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435603PMC
April 2019
2 Reads

Seizures and Epilepsy.

Authors:
Emily L Johnson

Med Clin North Am 2019 Mar 3;103(2):309-324. Epub 2018 Dec 3.

Department of Neurology, Johns Hopkins School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287, USA. Electronic address:

Epilepsy affects 65 million people worldwide, and is a leading neurologic cause of loss of quality-adjusted life years. The diagnosis of seizures and epilepsy often depends on a careful history, and is supported with electroencephalogram and imaging. First-line treatment of epilepsy includes medical management. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00257125183012
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http://dx.doi.org/10.1016/j.mcna.2018.10.002DOI Listing
March 2019
27 Reads

[Features of maternal behavior in women with epilepsy].

Zh Nevrol Psikhiatr Im S S Korsakova 2018;118(10. Vyp. 2):76-81

Saint Petersburg State Pediatric Medical University, St.-Petersburg, Russia.

Aim: To study characteristics of maternal behavior in women with epilepsy.

Material And Methods: Twenty-three women with epilepsy, aged 25-35 years, with one or more children, aged 0-10 years, were interviewed. Thirty age-matched women were included in the control group. Read More

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http://dx.doi.org/10.17116/jnevro201811810276DOI Listing
January 2018
2 Reads

Cannabidiol (Epidiolex) for epilepsy.

Authors:

Med Lett Drugs Ther 2018 Nov;60(1559):182-184

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November 2018
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Teratogenicity of antiepileptic drugs.

Curr Opin Neurol 2019 Apr;32(2):246-252

Department of Internal Medicine and Therapeutics, University of Pavia, Clinical Trial Center, IRCCS Mondino Foundation, Pavia, Italy.

Purpose Of Review: We review data on the comparative teratogenicity of antiepileptic drugs (AEDs), focusing on major congenital malformations (MCMs), intrauterine growth restriction, impaired cognitive development, and behavioral adverse effects following prenatal exposure.

Recent Findings: Prospective registries and meta-analyses have better defined the risk of MCMs in offspring exposed to individual AEDs at different dose levels. Valproate is the drug with the highest risk, whereas prevalence of MCMs is lowest with lamotrigine, levetiracetam, and oxcarbazepine. Read More

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http://dx.doi.org/10.1097/WCO.0000000000000659DOI Listing
April 2019
24 Reads

Fetal antiepileptic drug exposure and learning and memory functioning at 6 years of age: The NEAD prospective observational study.

Epilepsy Behav 2019 Mar 17;92:154-164. Epub 2019 Jan 17.

Neurology, Emory University, Atlanta, GA, United States of America.

The Neurodevelopmental Effects of Antiepileptic Drugs (NEAD) Study was a prospective observational multicenter study in the USA and UK, which enrolled pregnant women with epilepsy on antiepileptic drug (AED) monotherapy from 1999 to 2004. The study aimed to determine if differential long-term neurodevelopmental effects exist across four commonly used AEDs (carbamazepine, lamotrigine, phenytoin, and valproate). In this report, we examine fetal AED exposure effects on learning and memory functions in 221 six-year-old children (including four sets of twins) whose mothers took one of these AEDs during pregnancy. Read More

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http://dx.doi.org/10.1016/j.yebeh.2018.12.031DOI Listing
March 2019
13 Reads

Association of Prenatal Exposure to Valproate and Other Antiepileptic Drugs With Risk for Attention-Deficit/Hyperactivity Disorder in Offspring.

JAMA Netw Open 2019 01 4;2(1):e186606. Epub 2019 Jan 4.

The National Centre for Register-Based Research, Department of Economics and Business Economics, Business and Social Science, Aarhus University, Aarhus, Denmark.

Importance: Valproate is an antiepileptic drug (AED) used in the treatment of epilepsy and many other neurological and psychiatric disorders. Its use in pregnancy is associated with increased risks of congenital malformations and adverse neurodevelopment in the offspring and may be associated with an increased risk of attention-deficit/hyperactivity disorder (ADHD).

Objective: To determine whether prenatal exposure to valproate and other AEDs is associated with an increased risk of ADHD in the offspring. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2018.6606DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324310PMC
January 2019
18 Reads

Epilepsy in Children: From Diagnosis to Treatment with Focus on Emergency.

J Clin Med 2019 Jan 2;8(1). Epub 2019 Jan 2.

Department of Anesthesiology, AOU Policlinico-Vittorio Emanuele, University of Catania Via S. Sofia, 78, 95123 Catania, Italy.

Seizures are defined as a transient occurrence of signs and symptoms due to the abnormal, excessive, or synchronous neuronal activity in the brain characterized by abrupt and involuntary skeletal muscle activity. An early diagnosis, treatment, and specific medical support must be performed to prevent Status Epilepticus (SE). Seizure onset, especially in the child population, is related to specific risk factors like positive family history, fever, infections, neurological comorbidity, premature birth, mother's alcohol abuse, and smoking in pregnancy. Read More

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http://www.mdpi.com/2077-0383/8/1/39
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http://dx.doi.org/10.3390/jcm8010039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352402PMC
January 2019
15 Reads

Perinatal outcome and healthcare resource utilization in the first year of life after antiepileptic exposure during pregnancy.

Epilepsy Behav 2019 Mar 29;92:14-17. Epub 2018 Dec 29.

Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy.

Healthcare administrative databases of Italy's Lombardy Region were analyzed with the aim to assess perinatal outcomes and healthcare resource utilization during the first year of life in infants exposed to antiepileptic drugs (AEDs) during pregnancy. Drug prescriptions dispensed in the 12 months before delivery to women, who delivered between 2005 and 2011, were analyzed. Neonates were classified as cases if exposed to AEDs, and each case was randomly matched to seven controls. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15255050183070
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http://dx.doi.org/10.1016/j.yebeh.2018.09.033DOI Listing
March 2019
8 Reads

Associations between early term and late/post term infants and development of epilepsy: A cohort study.

PLoS One 2018 31;13(12):e0210181. Epub 2018 Dec 31.

Department of Women's and Children's Health, North Bristol NHS Trust, Bristol, United Kingdom.

Background: While life-long impacts exist for infants born one or two weeks early little evidence exists for those infants born after their due date. However interventions could be used to expedite birth if the risks of continuing the pregnancy are higher than intervening. It is known that the risk of epilepsy in childhood is higher in infants exposed to perinatal compromise and therefore may be useful as a proxy for intrapartum compromise. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210181PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312375PMC
December 2018
2 Reads

Antiepileptic drugs and foetal malformation: analysis of 20 years of data in a pregnancy register.

Seizure 2019 Feb 19;65:6-11. Epub 2018 Dec 19.

Royal Brisbane and Women's Hospital and School of Medicine and Biomedical Science, University of Queensland, Brisbane, Queensland, 4027 Australia.

Purpose: This paper reports additional data supplementing earlier publications based on Australian Pregnancy Register (APR) data.

Method: Over 20 years, the APR has collected Information on pregnancies in Australian women with epilepsy (WWE), untreated WWE and those taking AEDs for other indications. Contact is by telephone, at set intervals. Read More

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http://dx.doi.org/10.1016/j.seizure.2018.12.006DOI Listing
February 2019
3 Reads

Levetiracetam for epilepsy: an evidence map of efficacy, safety and economic profiles.

Neuropsychiatr Dis Treat 2019 17;15:1-19. Epub 2018 Dec 17.

Department of Pharmacy, Peking University Third Hospital, Beijing, China,

Objective: To evaluate the efficacy, safety and economics of levetiracetam (LEV) for epilepsy.

Materials And Methods: PubMed, Scopus, the Cochrane Library, OpenGrey.eu and ClinicalTrials. Read More

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https://www.dovepress.com/levetiracetam-for-epilepsy-an-evid
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http://dx.doi.org/10.2147/NDT.S181886DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301299PMC
December 2018
19 Reads

Reliability of information about the use of antiepileptic drugs during pregnancy from three major web search engines in China.

PLoS One 2018 26;13(12):e0208783. Epub 2018 Dec 26.

Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, P.R. China.

Objectives: The objective of this study was to assess the reliability of online information, as provided by three major search engines in China, about the usage of antiepileptic drugs (AEDs) during pregnancy.

Method: Over eight weeks, six physicians conducted a literature search on six computers and six smartphones at a frequency of once per week. During each web search on each computer and smartphone, three major search engines in China were used, namely, Baidu, Sogou and 360. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0208783PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306163PMC
December 2018
3 Reads

Agenesis of the corpus callosum with interhemispheric cyst: clinical implications and outcome.

BMJ Case Rep 2018 Dec 3;11(1). Epub 2018 Dec 3.

Neonatology, KK Women's and Children's Hospital, Singapore.

We describe two cases of agenesis of the corpus callosum (ACC) with interhemispheric cyst (IHC). Case 1: a male infant was born at 36 weeks gestation with a history of second trimester fetal ultrasound (US) scan and MRI showing ACC with IHC. His head circumference at birth and 5 months was at 90th centile. Read More

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http://dx.doi.org/10.1136/bcr-2018-227366DOI Listing
December 2018
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Therapeutic strategies for treating epilepsy during pregnancy.

Expert Opin Pharmacother 2019 02 10;20(3):323-332. Epub 2018 Dec 10.

a Department of Neurology , Beaumont Hospital , Dublin , Ireland.

Introduction: Counseling for women with epilepsy of childbearing potential surrounding pregnancy issues is of the utmost importance and should be done when antiepileptic medications are prescribed and reviewed regularly at clinic visits. Physicians must be familiar with risks associated with antiepileptic medication, and endeavor to minimize risks to a fetus while selecting best medications for epilepsy type.

Areas Covered: The authors discuss the role of folic acid, updated evidence relating to the occurrence of major congenital malformations and neurocognitive risks associated with antiepileptic medication. Read More

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http://dx.doi.org/10.1080/14656566.2018.1550073DOI Listing
February 2019
3 Reads

Metabolome-wide association study of anti-epileptic drug treatment during pregnancy.

Toxicol Appl Pharmacol 2019 Jan 4;363:122-130. Epub 2018 Dec 4.

Clinical Biomarkers Laboratory, Division of Pulmonary, Allergy, and Critical Care Medicine, Emory University School of Medicine, Atlanta, GA, United States. Electronic address:

Pregnant women with epilepsy (PWWE) require continuous anti-epileptic drug (AED) treatment to avoid risk to themselves and fetal risks secondary to maternal seizures, resulting in prolonged AED exposure to the developing embryo and fetus. The objectives of this study were to determine whether high-resolution metabolomics is able to link the metabolite profile of PWWE receiving lamotrigine or levetiracetam for seizure control to associated pharmacodynamic (PD) biological responses. Untargeted metabolomic analysis of plasma obtained from 82 PWWE was completed using high-resolution mass spectrometry. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0041008X183053
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http://dx.doi.org/10.1016/j.taap.2018.12.001DOI Listing
January 2019
17 Reads

Status epilepticus in pregnancy: Most rare and most challenging.

Authors:
Gagandeep Singh

Neurol India 2018 Nov-Dec;66(6):1593-1594

Department of Neurology, Dayanand Medical College, Ludhiana, Punjab, India; Department of Clinical and Experimental Epilepsy, Institute of Neurology, Queen Square, London, WC1N 3BG, UK.

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http://dx.doi.org/10.4103/0028-3886.246227DOI Listing
December 2018
2 Reads