4,421 results match your criteria Seizure Disorders in Pregnancy


Collaboration of Care for Women with Epilepsy in their Reproductive Years.

J Womens Health (Larchmt) 2019 Feb 15. Epub 2019 Feb 15.

2 New York University School of Medicine, New York, New York.

Over half a million women of childbearing age have epilepsy, many of which will require family planning care at some point in their reproductive years. Matters relating to contraception, pregnancy, fertility, and sexual functioning are all impacted to varying degrees by the use of antiepileptic drugs (AEDs) to treat epilepsy and require active management by a woman's neurologist. It is important that a woman's obstetrician/gynecologist (OBGYN) and internist are aware of the way in which their care may be related to her epilepsy care and how this can be successfully comanaged with her neurologist. Read More

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http://dx.doi.org/10.1089/jwh.2018.7506DOI Listing
February 2019

Treatment of Juvenile Myoclonic Epilepsy in Patients of Child-Bearing Potential.

CNS Drugs 2019 Feb 11. Epub 2019 Feb 11.

Epilepsy Unit, Hôpital Gui de Chauliac, 80 Avenue Fliche, 34295, Montpellier Cedex 05, France.

Juvenile myoclonic epilepsy (JME) is both a frequent and a very characteristic epileptic syndrome with female preponderance. Treatment of JME in women of childbearing potential must consider multiple factors such as desire for pregnancy, use of contraception, seizure control and previously used antiepileptic drugs (AEDs). Approximately 85% of cases are well controlled with valproate, which remains the reference AED in JME but is nowadays considered unsafe for the expecting mother and her fetus. Read More

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http://link.springer.com/10.1007/s40263-018-00602-2
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http://dx.doi.org/10.1007/s40263-018-00602-2DOI Listing
February 2019
2 Reads

Trial of labor after cesarean section in risk pregnancies: a population-based cohort study.

Acta Obstet Gynecol Scand 2019 Feb 8. Epub 2019 Feb 8.

Department of Clinical Science, University of Bergen, Norway.

Introduction: In most pregnancies after a cesarean section, a trial of labor is an option. The objective of the study was to explore trial of labor and its failure in pregnancies with medical risk conditions, in a population with a high trial of labor rate.

Material And Methods: In a cohort study (n=57 109), using data from the Medical Birth Registry of Norway 1989-2014, women with a second delivery after a first pregnancy cesarean section were included. Read More

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http://dx.doi.org/10.1111/aogs.13565DOI Listing
February 2019
1 Read

Neurological diseases in pregnancy.

Curr Opin Obstet Gynecol 2019 Feb 5. Epub 2019 Feb 5.

Department of Obstetrics and Gynecology, University of Rochester Medical Center, Rochester, New York, USA.

Purpose Of Review: To summarize recent research findings and current concepts related to care of neurologic diseases in pregnancy and the risks of pregnancy to the mother-infant dyad. Recent publications related to best practices for neurologic care, risks of pregnancy, rate of relapse during and after pregnancy, as well as medication safety in pregnancy and lactation for more commonly used neurologic medications are reviewed.

Recent Findings: Data continues to grow that women with neurologic conditions can experience pregnancy with minimal risks. Read More

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http://dx.doi.org/10.1097/GCO.0000000000000525DOI Listing
February 2019
1 Read

Prenatal detection of right aortic arch.

Arch Gynecol Obstet 2019 Jan 31. Epub 2019 Jan 31.

Department of Gynecology and Obstetrics, Division of Feto-Maternal Medicine, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.

Purpose: To examine an unselective population of fetuses with right aortic arch (RAA) and suggest perinatal management. Second, to evaluate the importance and possible implication of fetal MRI in those cases.

Methods: Retrospective study of 36 patients with RAA diagnosed prenatally between 2006 and 2017 in a tertiary referral center. Read More

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http://dx.doi.org/10.1007/s00404-019-05056-5DOI Listing
January 2019
1 Read

Seizures and Epilepsy.

Authors:
Emily L Johnson

Med Clin North Am 2019 Mar 3;103(2):309-324. Epub 2018 Dec 3.

Department of Neurology, Johns Hopkins School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287, USA. Electronic address:

Epilepsy affects 65 million people worldwide, and is a leading neurologic cause of loss of quality-adjusted life years. The diagnosis of seizures and epilepsy often depends on a careful history, and is supported with electroencephalogram and imaging. First-line treatment of epilepsy includes medical management. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00257125183012
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http://dx.doi.org/10.1016/j.mcna.2018.10.002DOI Listing
March 2019
11 Reads

[Features of maternal behavior in women with epilepsy].

Zh Nevrol Psikhiatr Im S S Korsakova 2018 ;118(10. Vyp. 2):76-81

Saint Petersburg State Pediatric Medical University, St.-Petersburg, Russia.

Aim: To study characteristics of maternal behavior in women with epilepsy.

Material And Methods: Twenty-three women with epilepsy, aged 25-35 years, with one or more children, aged 0-10 years, were interviewed. Thirty age-matched women were included in the control group. Read More

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http://dx.doi.org/10.17116/jnevro201811810276DOI Listing
January 2018
1 Read

Cannabidiol (Epidiolex) for epilepsy.

Authors:

Med Lett Drugs Ther 2018 Nov;60(1559):182-184

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November 2018

Teratogenicity of antiepileptic drugs.

Curr Opin Neurol 2019 Jan 16. Epub 2019 Jan 16.

Department of Internal Medicine and Therapeutics, University of Pavia, Clinical Trial Center, IRCCS Mondino Foundation, Pavia, Italy.

Purpose Of Review: We review data on the comparative teratogenicity of antiepileptic drugs (AEDs), focusing on major congenital malformations (MCMs), intrauterine growth restriction, impaired cognitive development, and behavioral adverse effects following prenatal exposure.

Recent Findings: Prospective registries and meta-analyses have better defined the risk of MCMs in offspring exposed to individual AEDs at different dose levels. Valproate is the drug with the highest risk, whereas prevalence of MCMs is lowest with lamotrigine, levetiracetam, and oxcarbazepine. Read More

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http://dx.doi.org/10.1097/WCO.0000000000000659DOI Listing
January 2019
9 Reads

Fetal antiepileptic drug exposure and learning and memory functioning at 6 years of age: The NEAD prospective observational study.

Epilepsy Behav 2019 Jan 17;92:154-164. Epub 2019 Jan 17.

Neurology, Emory University, Atlanta, GA, United States of America.

The Neurodevelopmental Effects of Antiepileptic Drugs (NEAD) Study was a prospective observational multicenter study in the USA and UK, which enrolled pregnant women with epilepsy on antiepileptic drug (AED) monotherapy from 1999 to 2004. The study aimed to determine if differential long-term neurodevelopmental effects exist across four commonly used AEDs (carbamazepine, lamotrigine, phenytoin, and valproate). In this report, we examine fetal AED exposure effects on learning and memory functions in 221 six-year-old children (including four sets of twins) whose mothers took one of these AEDs during pregnancy. Read More

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http://dx.doi.org/10.1016/j.yebeh.2018.12.031DOI Listing
January 2019
6 Reads

Association of Prenatal Exposure to Valproate and Other Antiepileptic Drugs With Risk for Attention-Deficit/Hyperactivity Disorder in Offspring.

JAMA Netw Open 2019 Jan 4;2(1):e186606. Epub 2019 Jan 4.

The National Centre for Register-Based Research, Department of Economics and Business Economics, Business and Social Science, Aarhus University, Aarhus, Denmark.

Importance: Valproate is an antiepileptic drug (AED) used in the treatment of epilepsy and many other neurological and psychiatric disorders. Its use in pregnancy is associated with increased risks of congenital malformations and adverse neurodevelopment in the offspring and may be associated with an increased risk of attention-deficit/hyperactivity disorder (ADHD).

Objective: To determine whether prenatal exposure to valproate and other AEDs is associated with an increased risk of ADHD in the offspring. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2018.6606DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324310PMC
January 2019
9 Reads

Epilepsy in Children: From Diagnosis to Treatment with Focus on Emergency.

J Clin Med 2019 Jan 2;8(1). Epub 2019 Jan 2.

Department of Anesthesiology, AOU Policlinico-Vittorio Emanuele, University of Catania Via S. Sofia, 78, 95123 Catania, Italy.

Seizures are defined as a transient occurrence of signs and symptoms due to the abnormal, excessive, or synchronous neuronal activity in the brain characterized by abrupt and involuntary skeletal muscle activity. An early diagnosis, treatment, and specific medical support must be performed to prevent Status Epilepticus (SE). Seizure onset, especially in the child population, is related to specific risk factors like positive family history, fever, infections, neurological comorbidity, premature birth, mother's alcohol abuse, and smoking in pregnancy. Read More

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http://www.mdpi.com/2077-0383/8/1/39
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http://dx.doi.org/10.3390/jcm8010039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352402PMC
January 2019
5 Reads

Perinatal outcome and healthcare resource utilization in the first year of life after antiepileptic exposure during pregnancy.

Epilepsy Behav 2018 Dec 29;92:14-17. Epub 2018 Dec 29.

Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy.

Healthcare administrative databases of Italy's Lombardy Region were analyzed with the aim to assess perinatal outcomes and healthcare resource utilization during the first year of life in infants exposed to antiepileptic drugs (AEDs) during pregnancy. Drug prescriptions dispensed in the 12 months before delivery to women, who delivered between 2005 and 2011, were analyzed. Neonates were classified as cases if exposed to AEDs, and each case was randomly matched to seven controls. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15255050183070
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http://dx.doi.org/10.1016/j.yebeh.2018.09.033DOI Listing
December 2018
3 Reads

Associations between early term and late/post term infants and development of epilepsy: A cohort study.

PLoS One 2018 31;13(12):e0210181. Epub 2018 Dec 31.

Department of Women's and Children's Health, North Bristol NHS Trust, Bristol, United Kingdom.

Background: While life-long impacts exist for infants born one or two weeks early little evidence exists for those infants born after their due date. However interventions could be used to expedite birth if the risks of continuing the pregnancy are higher than intervening. It is known that the risk of epilepsy in childhood is higher in infants exposed to perinatal compromise and therefore may be useful as a proxy for intrapartum compromise. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210181PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312375PMC
December 2018
1 Read

Antiepileptic drugs and foetal malformation: analysis of 20 years of data in a pregnancy register.

Seizure 2019 Feb 19;65:6-11. Epub 2018 Dec 19.

Royal Brisbane and Women's Hospital and School of Medicine and Biomedical Science, University of Queensland, Brisbane, Queensland, 4027 Australia.

Purpose: This paper reports additional data supplementing earlier publications based on Australian Pregnancy Register (APR) data.

Method: Over 20 years, the APR has collected Information on pregnancies in Australian women with epilepsy (WWE), untreated WWE and those taking AEDs for other indications. Contact is by telephone, at set intervals. Read More

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http://dx.doi.org/10.1016/j.seizure.2018.12.006DOI Listing
February 2019
2 Reads

Levetiracetam for epilepsy: an evidence map of efficacy, safety and economic profiles.

Neuropsychiatr Dis Treat 2019 17;15:1-19. Epub 2018 Dec 17.

Department of Pharmacy, Peking University Third Hospital, Beijing, China,

Objective: To evaluate the efficacy, safety and economics of levetiracetam (LEV) for epilepsy.

Materials And Methods: PubMed, Scopus, the Cochrane Library, OpenGrey.eu and ClinicalTrials. Read More

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https://www.dovepress.com/levetiracetam-for-epilepsy-an-evid
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http://dx.doi.org/10.2147/NDT.S181886DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301299PMC
December 2018
11 Reads

Reliability of information about the use of antiepileptic drugs during pregnancy from three major web search engines in China.

PLoS One 2018 26;13(12):e0208783. Epub 2018 Dec 26.

Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, P.R. China.

Objectives: The objective of this study was to assess the reliability of online information, as provided by three major search engines in China, about the usage of antiepileptic drugs (AEDs) during pregnancy.

Method: Over eight weeks, six physicians conducted a literature search on six computers and six smartphones at a frequency of once per week. During each web search on each computer and smartphone, three major search engines in China were used, namely, Baidu, Sogou and 360. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0208783PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306163PMC
December 2018
2 Reads

Therapeutic strategies for treating epilepsy during pregnancy.

Expert Opin Pharmacother 2019 Feb 10;20(3):323-332. Epub 2018 Dec 10.

a Department of Neurology , Beaumont Hospital , Dublin , Ireland.

Introduction: Counseling for women with epilepsy of childbearing potential surrounding pregnancy issues is of the utmost importance and should be done when antiepileptic medications are prescribed and reviewed regularly at clinic visits. Physicians must be familiar with risks associated with antiepileptic medication, and endeavor to minimize risks to a fetus while selecting best medications for epilepsy type. Areas covered: The authors discuss the role of folic acid, updated evidence relating to the occurrence of major congenital malformations and neurocognitive risks associated with antiepileptic medication. Read More

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http://dx.doi.org/10.1080/14656566.2018.1550073DOI Listing
February 2019
1 Read

Metabolome-wide association study of anti-epileptic drug treatment during pregnancy.

Toxicol Appl Pharmacol 2019 Jan 4;363:122-130. Epub 2018 Dec 4.

Clinical Biomarkers Laboratory, Division of Pulmonary, Allergy, and Critical Care Medicine, Emory University School of Medicine, Atlanta, GA, United States. Electronic address:

Pregnant women with epilepsy (PWWE) require continuous anti-epileptic drug (AED) treatment to avoid risk to themselves and fetal risks secondary to maternal seizures, resulting in prolonged AED exposure to the developing embryo and fetus. The objectives of this study were to determine whether high-resolution metabolomics is able to link the metabolite profile of PWWE receiving lamotrigine or levetiracetam for seizure control to associated pharmacodynamic (PD) biological responses. Untargeted metabolomic analysis of plasma obtained from 82 PWWE was completed using high-resolution mass spectrometry. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0041008X183053
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http://dx.doi.org/10.1016/j.taap.2018.12.001DOI Listing
January 2019
10 Reads

Status epilepticus in pregnancy: Most rare and most challenging.

Authors:
Gagandeep Singh

Neurol India 2018 Nov-Dec;66(6):1593-1594

Department of Neurology, Dayanand Medical College, Ludhiana, Punjab, India; Department of Clinical and Experimental Epilepsy, Institute of Neurology, Queen Square, London, WC1N 3BG, UK.

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http://dx.doi.org/10.4103/0028-3886.246227DOI Listing
December 2018
1 Read

Antiepileptic drug treatment during pregnancy and delivery in women with epilepsy-A retrospective single center study.

Epilepsy Res 2019 Jan 20;149:66-69. Epub 2018 Nov 20.

Department of Neurology, Rabin Medical Center - Beilinson Hospital, Petach Tikva, Israel; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address:

Purpose: Antiepileptic drugs (AED) are among the most common teratogenic drugs prescribed to women of childbearing age. During pregnancy, the risk of seizures has to be weight against the use of AED treatment. Primary goal was to observe and describe AED treatment policy and its changes during an eleven-year period at our third referral center. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2018.11.010DOI Listing
January 2019
2 Reads

Implementing a new adolescent epilepsy service: Improving patient experience and readiness for transition.

J Paediatr Child Health 2018 Nov 25. Epub 2018 Nov 25.

Department of Neurology, Sydney Children's Hospital, Sydney, New South Wales, Australia.

Aim: To implement and appraise a new model of care in terms of: patient experience, knowledge of epilepsy, readiness for transition and emotional and behavioural support in a new purpose-built facility for adolescents and young adults.

Methods: The new model of care included: upskilling of neurology staff in adolescent engagement and provision of group education sessions on epilepsy and mental health (MH), along with MH support, in a new purpose-built adolescent facility. Parameters examined pre- and post-attendance at the new clinic included: adolescent experience of service delivery, transition readiness, emotional and behavioural well-being, epilepsy knowledge and medication adherence. Read More

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http://dx.doi.org/10.1111/jpc.14301DOI Listing
November 2018
1 Read

Epilepsy in Pregnancy.

Neurol Clin 2019 Feb;37(1):53-62

Department of Neurology, Mount Sinai Downtown, 10 Union Square East Suite 5D, New York, NY 10003, USA.

Epilepsy is a prevalent, chronic, and serious neurologic disease affecting many women of childbearing age. Specific concerns, including contraception, fertility, teratogenic risk of antiepileptic drugs, delivery, and breastfeeding, are addressed in this article. Evidence-based counseling and management strategies are provided to help clinicians and women with epilepsy through the different stages of pregnancy. Read More

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http://dx.doi.org/10.1016/j.ncl.2018.09.008DOI Listing
February 2019
1 Read

Contraception for Adolescents with Medically Complex Conditions.

Authors:
Linda Carmine

Curr Probl Pediatr Adolesc Health Care 2018 Dec 19;48(12):345-357. Epub 2018 Nov 19.

Division of Adolescent Medicine, Cohen Children's Medical Center, Northwell Health, 410 Lakeville Road, Suite 108, New Hyde Park, NY 11042, United States; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, United States. Electronic address:

Both the World Health Organization (WHO) and the Centers for Disease Control and Prevention (CDC) have developed, published, and updated evidence-based guidelines to support medical providers in the provision of contraceptives to patients with specific medical conditions or characteristics. The goal of these guidelines is to provide recommendations on the safe use of contraceptives with the goal of removing unnecessary medical barriers to access and use of contraceptives, thus decreasing the number of unintended pregnancies. Many medical conditions increase a patient's risk of venous thromboembolism; a risk that may also be increased with specific contraceptives. Read More

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http://dx.doi.org/10.1016/j.cppeds.2018.11.004DOI Listing
December 2018
18 Reads

Intellectual functioning in clinically confirmed fetal valproate syndrome.

Neurotoxicol Teratol 2019 Jan - Feb;71:16-21. Epub 2018 Nov 16.

School of Life and Health Sciences, Aston University, Aston Triangle, Birmingham B4 7ET, UK; Clinical Sciences, Murdoch Children's Research Institute, Flemington Road, Parkville, Victoria 3052, Australia.

Background: An increased risk of impaired intelligence (IQ) has been documented in valproate-exposed children, but investigations have not previously focused on those with a clinical diagnosis of Fetal Valproate Syndrome (FVS).

Methods: This cross sectional observational study recruited individuals with a diagnosis of FVS and completed standardized assessments of intellectual abilities making comparisons to a normative comparison group. Both mean difference (MD) and prevalence of scores below the lower average range were analyzed. Read More

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http://dx.doi.org/10.1016/j.ntt.2018.11.003DOI Listing
November 2018
1 Read

Cesarean section in Australian women with epilepsy.

Epilepsy Behav 2018 Dec 7;89:126-129. Epub 2018 Nov 7.

Royal Brisbane and Women's Hospital and School of Medicine and Biomedical Science, University of Queensland, Brisbane, Queensland 4027, Australia.

The literature suggests that cesarean delivery or birth is carried out more often in pregnant women with epilepsy (WWE) than in pregnant women in the general population. Data were utilized from the Australian Pregnancy Register (APR) for Women on Antiepileptic Medication to investigate this issue in Australia. Over almost two decades, the mean CS rate in 1900 APR women was 39. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15255050183066
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http://dx.doi.org/10.1016/j.yebeh.2018.10.008DOI Listing
December 2018
8 Reads

Increased rate of acute caesarean sections in women with epilepsy: results from the Oppland Perinatal Database in Norway.

Eur J Neurol 2018 Nov 10. Epub 2018 Nov 10.

National Centre for Epilepsy, Oslo University Hospital, Oslo.

Background And Purpose: Studies in women with epilepsy (WWE) regarding pregnancy and labour complications have disclosed contradictory results. Our purpose was to investigate whether WWE have a higher risk of acute caesarean section (CS) or pregnancy complications than women without epilepsy or women with other chronic diseases and, if we found a higher risk, to explore potential explanations.

Methods: The study used prospectively registered obstetric data from the Oppland Perinatal Database in the period 2001-2011, containing information on 18 244 births, including 110 singleton pregnancies in mothers with validated epilepsy. Read More

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http://doi.wiley.com/10.1111/ene.13865
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http://dx.doi.org/10.1111/ene.13865DOI Listing
November 2018
7 Reads

Calcium Signaling in Vertebrate Development and Its Role in Disease.

Int J Mol Sci 2018 Oct 30;19(11). Epub 2018 Oct 30.

College of William and Mary, Williamsburg, VA 23187, USA.

Accumulating evidence over the past three decades suggests that altered calcium signaling during development may be a major driving force for adult pathophysiological events. Well over a hundred human genes encode proteins that are specifically dedicated to calcium homeostasis and calcium signaling, and the majority of these are expressed during embryonic development. Recent advances in molecular techniques have identified impaired calcium signaling during development due to either mutations or dysregulation of these proteins. Read More

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http://www.mdpi.com/1422-0067/19/11/3390
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http://dx.doi.org/10.3390/ijms19113390DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274931PMC
October 2018
1 Read

Valproic acid transport in the choriocarcinoma placenta cell line JEG-3 proceeds independently of the proton-dependent transporters MCT1 and MCT4.

Drug Metab Pharmacokinet 2018 Dec 5;33(6):270-274. Epub 2018 Apr 5.

Laboratory of Clinical Pharmaceutics & Therapeutics, Division of Pharmasciences, Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12-jo, Nishi-6-chome, Kita-ku, Sapporo 060-0812, Japan; Department of Pharmacy, Hokkaido University Hospital, Sapporo 060-8648, Japan. Electronic address:

Medication therapy is the first line of treatment in the management of epilepsy. Fetal exposure to valproic acid (VPA), an antiepileptic drug, poses an elevated risk of teratogenicity in early pregnancy. Some studies have reported that monocarboxylate transporters (MCTs) may be involved in the placental transport of VPA. Read More

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http://dx.doi.org/10.1016/j.dmpk.2018.03.004DOI Listing
December 2018
3 Reads

Association of Unintended Pregnancy With Spontaneous Fetal Loss in Women With Epilepsy: Findings of the Epilepsy Birth Control Registry.

JAMA Neurol 2018 Oct 15. Epub 2018 Oct 15.

Harvard Neuroendocrine Unit, Beth Israel Deaconess Medical Center, Boston, Massachusetts.

Importance: If unintended pregnancy is common among women with epilepsy and is associated with increased risk of spontaneous fetal loss (SFL), it is important to develop guidelines for safe and effective contraception for this community.

Objective: To assess whether planned pregnancy is a determinant of SFL in women with epilepsy.

Design, Setting, And Participants: The Epilepsy Birth Control Registry conducted this web-based, retrospective survey between 2010 and 2014. Read More

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http://dx.doi.org/10.1001/jamaneurol.2018.3089DOI Listing
October 2018
3 Reads

Anti-NMDAR encephalitis complicating pregnancy.

Pract Neurol 2018 Oct 10. Epub 2018 Oct 10.

Department of Neurology, Charing Cross Hospital, Imperial College Healthcare NHS Trust, London, UK

Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis was first reported in 2005 in four patients with ovarian teratomas; there have been many further cases reported since the antigen for the NMDAR antibody was confirmed in 2007. Patients characteristically have a well-defined set of features, characterised by psychiatric disturbance, seizures and cognitive disturbance, followed by movement disorders, disorders of consciousness and dysautonomia. To date, 14 cases of NMDAR encephalitis have been described in the context of pregnancy. Read More

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http://pn.bmj.com/lookup/doi/10.1136/practneurol-2018-002042
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http://dx.doi.org/10.1136/practneurol-2018-002042DOI Listing
October 2018
4 Reads

Diagnosis of tuberous sclerosis complex in the fetus.

Eur J Paediatr Neurol 2018 Nov 12;22(6):1027-1034. Epub 2018 Sep 12.

1st Department of Pediatrics, Developmental Center "A. Fokas", Aristotle University of Thessaloniki, "Hippokratio" General Hospital, Thessaloniki, Greece. Electronic address:

Tuberous sclerosis complex is a dominantly inherited genetic disorder of striking clinical variability. It is caused by mutations in either TSC1 or TSC2 gene, which regulate cell growth and proliferation by inhibition of mTORC1 signaling. TS is characterized by the development of benign tumors in many tissues and organs and its neurological manifestations include epilepsy, autism, cognitive and behavioral dysfunction, and giant cell tumors. Read More

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http://dx.doi.org/10.1016/j.ejpn.2018.08.005DOI Listing
November 2018
9 Reads

Maternal death in women with epilepsy: Smaller scope studies.

Neurology 2018 Oct 26;91(18):e1716-e1720. Epub 2018 Sep 26.

From the Department of Neurology (J.C.), Aarhus University Hospital; and Research Unit for General Practice (C.V.), Department of Public Health, and Section for Epidemiology (B.H.B.), Department of Public Health, Aarhus University, Denmark.

Objective: To determine the maternal mortality in women with epilepsy.

Methods: This was a matched case-control study of pregnant women in Denmark who were born in Denmark between January 1, 1962, and December 31, 1994, and who were alive on their 18th birthday. We defined maternal mortality as deaths in pregnancy and the first 42 days after termination of pregnancy. Read More

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http://dx.doi.org/10.1212/WNL.0000000000006426DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207413PMC
October 2018
10 Reads

In utero beta-2-adrenergic agonists exposure and risk of epilepsy: A Danish nationwide population-based cohort study.

Pharmacoepidemiol Drug Saf 2018 Nov 7;27(11):1200-1208. Epub 2018 Sep 7.

Department of Clinical Epidemiology, Aarhus University Hospital, Olof Palmes Alle 43-45, DK-8200, Aarhus N, Denmark.

Purpose: To examine the association between maternal use of beta-2-adrenergic agonists (β2AAs) and the risk of epilepsy in offspring.

Methods: A nationwide retrospective cohort study was performed based on Danish registries. Children of mothers who used β2AAs during pregnancy were allocated to the exposed group and other children to the unexposed group. Read More

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http://dx.doi.org/10.1002/pds.4648DOI Listing
November 2018
3 Reads

First and Second Trimester Biochemical Markers in Maternal Epilepsy: A Case-Control Study.

Fetal Pediatr Pathol 2018 Sep 24:1-7. Epub 2018 Sep 24.

a Department of Obstetrics and Gynecology, Zekai Tahir Burak Women's Health Research and Education Hospital , Ankara , Turkey.

Background: Our aim is to investigate whether the maternal serum levels of first and second trimester serum analytes are altered in women with epilepsy in pregnancy.

Methods: Maternal serum biochemical markers (estriol, alpha-fetoprotein [AFP], human chorionic gonadotrophin [hCG], free β hCG, pregnancy-associated plasma protein-A) were compared in a series of 122 pregnant women with epilepsy and in a cohort of 122 normal pregnant women. The serum samples were obtained between 11-13 6/7 weeks and 16-18 weeks gestation. Read More

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http://dx.doi.org/10.1080/15513815.2018.1502381DOI Listing
September 2018
7 Reads

Review on the relevance of therapeutic drug monitoring of levetiracetam.

Seizure 2018 Nov 12;62:131-135. Epub 2018 Sep 12.

Department of Neurology, Academic Centre of Epileptology Kempenhaeghe Maastricht UMC+, The Netherlands; School for Mental Health and Neuroscience, Maastricht University Medical Centre, Maastricht, The Netherlands; School of Health Professions Education, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands.

Therapeutic Drug Monitoring (TDM) of anti-epileptic drugs (AEDs) is not routinely performed, although this can guide the dosage regimen to achieve greater efficacy and safety. Levetiracetam (LEV) has been introduced as an AED with an almost perfect pharmacokinetic (PK) profile. Nonetheless, recent research challenges this statement and therefore we aimed to explore factors that modify LEV PK. Read More

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http://dx.doi.org/10.1016/j.seizure.2018.09.004DOI Listing
November 2018
4 Reads

Posterior reversible encephalopathy syndrome in eclampsia.

Neurol India 2018 Sep-Oct;66(5):1316-1323

Department of Neurology, King George's Medical University, Lucknow, Uttar Pradesh, India.

Posterior reversible encephalopathy syndrome is characterized by acute headache, visual impairment, seizures, and altered mental status; neuroimaging may show cerebral edema affecting the parietal and occipital lobes of the brain. The objective of this article is to review the current understanding of posterior reversible encephalopathy syndrome in eclampsia. Literature was searched from PubMed, Scopus, and Google Scholar databases. Read More

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http://dx.doi.org/10.4103/0028-3886.241364DOI Listing
September 2018
3 Reads

Estrogen-related seizure exacerbation following hormone therapy for assisted reproduction in women with epilepsy.

Seizure 2018 Oct 30;61:200-202. Epub 2018 Aug 30.

IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy; Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.

Purpose: Exogenous estrogens might lead to seizure worsening in women with epilepsy (WWE) by lowering the seizure threshold and inducing glucuronidation in women taking lamotrigine. Assisted reproduction techniques are increasingly used and often require estrogenic and estrogen raising hormone therapy. We aimed at reporting their possible impact on seizures in WWE. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10591311183046
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http://dx.doi.org/10.1016/j.seizure.2018.08.024DOI Listing
October 2018
7 Reads

Antiepileptic drug clearances during pregnancy and clinical implications for women with epilepsy.

Neurology 2018 Sep 5;91(13):e1228-e1236. Epub 2018 Sep 5.

From Brigham and Women's Hospital (P.E.V., L.Q.C., P.B.P.), Harvard Medical School; Harvard Chan School of Public Health (S.P.), Boston, MA; University of Wisconsin School of Medicine and Public Health (Z.N.S.), Madison; University of Miami Miller School of Medicine (D.J.N.), FL; and Emory University School of Medicine (J.C.R.), Atlanta, GA.

Objective: To characterize the magnitude and time course of pregnancy-related clearance changes for different antiepileptic drugs (AEDs): levetiracetam, oxcarbazepine, topiramate, phenytoin, and valproate. A secondary aim was to determine if a decreased AED serum concentration was associated with increased seizure frequency.

Methods: Women with epilepsy were enrolled preconception or early in pregnancy and prospectively followed throughout pregnancy and the first postpartum year with daily diaries of AED doses, adherence, and seizures. Read More

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http://dx.doi.org/10.1212/WNL.0000000000006240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161546PMC
September 2018
15 Reads

Systematic review of the screening, diagnosis, and management of ADHD in children with epilepsy. Consensus paper of the Task Force on Comorbidities of the ILAE Pediatric Commission.

Epilepsia 2018 Oct 3;59(10):1867-1880. Epub 2018 Sep 3.

Division of Paediatric Neurology, Neuroscience Institute, Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town, Cape Town, South Africa.

Attention-deficit/hyperactivity disorder (ADHD) is a common and challenging comorbidity affecting many children with epilepsy. A working group under the International League Against Epilepsy (ILAE) Pediatric Commission identified key questions on the identification and management of ADHD in children with epilepsy. Systematic reviews of the evidence to support approaches to these questions were collated and graded using criteria from the American Academy of Neurology Practice Parameter. Read More

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http://doi.wiley.com/10.1111/epi.14549
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http://dx.doi.org/10.1111/epi.14549DOI Listing
October 2018
16 Reads

Children Prenatally Believed to have Isolated Mild Ventriculomegaly.

Ultrasound Obstet Gynecol 2018 Aug 31. Epub 2018 Aug 31.

Copenhagen University Hospital, Rigshospitalet, Center of Fetal Medicine, Copenhagen, Denmark.

Objectives: The aim of this study was to estimate the prevalence of specific neurodevelopmental disorders in children prenatally believed to have isolated mild ventriculomegaly in the second trimester of pregnancy to optimize the counselling process.

Methods: This was a nationwide register based study including all singleton pregnancies which had a first and second trimester scan in the period 1 January 2008 to 1 October 2014, identified through the Danish Fetal Medicine Database and from local clinical databases. All fetuses prenatally believed to have isolated mild ventriculomegaly (measurement of the atrium of the lateral ventricles between 10. Read More

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http://dx.doi.org/10.1002/uog.20111DOI Listing
August 2018
11 Reads