3,516 results match your criteria Seizure - European Journal of Epilepsy[Journal]


Control of focal impaired awareness seizures with an oral appliance in a patient with sleep apnea.

Seizure 2019 Apr 14;69:116-117. Epub 2019 Apr 14.

Sleep Unit of Cardiovascular Center, University of Lisbon, School of Medicine, Avenida Professor Egas Moniz, 1649-028, Portugal. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.seizure.2019.04.012DOI Listing

Incidence and risk factors of post-cranioplasty seizures.

Seizure 2019 Apr 13;69:115. Epub 2019 Apr 13.

Department of Neurosurgery, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.seizure.2019.04.009DOI Listing

Construction and analysis of a dysregulated lncRNA-associated ceRNA network in a rat model of temporal lobe epilepsy.

Seizure 2019 Apr 15;69:105-114. Epub 2019 Apr 15.

Department of Neurology, Xiangya Hospital, Central South University, Changsha, 410008, PR China; Neurology Institute of Xiangya Hospital, Central South University, Changsha, Hunan 410008, PR China. Electronic address:

Purpose: The aim of this work was to investigate expression and cross-talk between long noncoding RNAs (lncRNAs) and microRNAs (miRNAs) in a rat model of temporal lobe epilepsy (TLE).

Methods: Noncoding RNA chips were used to explore the expression and relationship between lncRNAs and miRNAs in a rat model of TLE. The expression of different lncRNAs and mRNAs was analysed by Pearson's correlation coefficient, and the function of each lncRNA was annotated by co-expressed genes based on gene ontology classification using DAVID. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10591311183057
Publisher Site
http://dx.doi.org/10.1016/j.seizure.2019.04.010DOI Listing
April 2019
1 Read

Novel variants and phenotypes widen the phenotypic spectrum of GABRG2-related disorders.

Seizure 2019 Mar 19;69:99-104. Epub 2019 Mar 19.

PEDEGO Research Unit, University of Oulu, Oulu, Finland; Medical Research Center, Oulu University Hospital, University of Oulu, Oulu, Finland; Biocenter Oulu, University of Oulu, Oulu, Finland; Department of Children and Adolescents, Division of Pediatric Neurology, Oulu University Hospital, Oulu, Finland.

Purpose: Next-generation sequencing (NGS) has made genetic testing of patients with epileptic encephalopathies easier - novel variants are discovered and new phenotypes described. Variants in the same gene - even the same variant - can cause different types of epilepsy and neurodevelopmental disorders. Our aim was to identify the genetic causes of epileptic encephalopathies in paediatric patients with complex phenotypes. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10591311173083
Publisher Site
http://dx.doi.org/10.1016/j.seizure.2019.03.010DOI Listing
March 2019
1 Read

Quality of life and correlating factors in children, adolescents with epilepsy, and their caregivers: A cross-sectional multicenter study from Germany.

Seizure 2019 Mar 29;69:92-98. Epub 2019 Mar 29.

Epilepsy Center Hessen and Department of Neurology, Philipps-University Marburg, Marburg (Lahn), Germany; Epilepsy Center Frankfurt Rhine-Main and Department of Neurology, Goethe University Frankfurt, Frankfurt am Main, Germany; LOEWE Center for Personalized Translational Epilepsy Research (CePTER), Goethe-University Frankfurt, Frankfurt am Main, Germany. Electronic address:

Purpose: To identify factors correlating with poorer quality of life (QoL) in children and adolescents with epilepsy and regarding QoL and depression of their caregivers in Germany.

Method: A cross-sectional multicenter study on QoL and depression was performed in two representative German states (Hessen and Schleswig-Holstein). Variance analysis, linear regression, and bivariate correlation were used to identify correlating factors for poorer QoL and symptoms of depression. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10591311183052
Publisher Site
http://dx.doi.org/10.1016/j.seizure.2019.03.016DOI Listing
March 2019
1 Read

Unverricht-Lundborg disease: Clinical course and seizure management based on the experience of polish centers.

Authors:
Anetta Lasek-Bal

Seizure 2019 Apr 10;69:87-91. Epub 2019 Apr 10.

Department of Neurology, School of Health Sciences, Medical University of Silesia in Katowice, 40-635, Katowice, Poland. Electronic address:

The purpose of this paper was to present our experience following the longterm treatment of 11 patients with Unverricht-Lundborg disease (ULD) confirmed by molecular testing.

Methods: We analyzed the clinical course, cognitive state, neuroimaging and neurophysiology results.

Results: The data were collected from 9 unrelated families (F/M: 4/7) aged 25-49. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10591311183065
Publisher Site
http://dx.doi.org/10.1016/j.seizure.2019.04.008DOI Listing
April 2019
2 Reads

Intraoperative ultrasonography (ioUS) characteristics of focal cortical dysplasia (FCD) type II b.

Seizure 2019 Mar 12;69:80-86. Epub 2019 Mar 12.

Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico C. Besta, Milan, Italy; Department of Neurological Surgery, Johns Hopkins Medical School, Baltimore, MD, USA.

Purpose: Focal cortical dysplasia (FCD) is one of the major causes of drug-resistant epilepsy. Surgery has proved to be the treatment of choice, however up to a third of patients experience only partial resection. Ill-defined borders and lesions embedded in eloquent areas are two of the main drawbacks of FCD surgery. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.seizure.2019.02.020DOI Listing

Effects of vagus nerve stimulation on symptoms of depression in patients with difficult-to-treat epilepsy.

Seizure 2019 Apr 3;69:77-79. Epub 2019 Apr 3.

Department of Neurosurgery, Charité University Hospital, Berlin, Germany.

Purpose: Vagus nerve stimulation (VNS) is well established in the treatment of epilepsy and disorders of depression. The prevalence of depression is high in patients with epilepsy, but still it remains unclear how patients with a comorbidity of epilepsy and symptoms of depression respond to VNS.

Methods: We investigated 59 patients with different subtypes of disorders of depression as a comorbidity of epilepsy, who underwent VNS-surgery. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.seizure.2019.04.001DOI Listing

Seizures and epilepsy following cranioplasty.

Seizure 2019 Apr 7;69:76. Epub 2019 Apr 7.

Department of Neurosurgery, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.seizure.2019.04.004DOI Listing
April 2019
1 Read

Long-term seizure outcome in patients with status epilepticus due to acute encephalitis.

Seizure 2019 Apr 8;69:70-75. Epub 2019 Apr 8.

Department of Neurology, Xijing Hospital, Fourth Military Medical University, Xi'an, China. Electronic address:

Purpose: To investigate the long-term seizure outcome in patients with convulsive status epilepticus (CSE) due to acute encephalitis and identify early predictors for terminal seizure remission.

Methods: Based on a prospective registry of CSE, consecutive patients with CSE due to acute encephalitis were enrolled from July 2009 to November 2017, with follow-up ending in November 2018. Variables during hospital stay, seizure outcomes within 1 month after status epilepticus (SE), and seizure outcomes within 3 months after acute phase of encephalitis were assessed for predicting terminal seizure freedom. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10591311193010
Publisher Site
http://dx.doi.org/10.1016/j.seizure.2019.04.005DOI Listing
April 2019
10 Reads

Risk of valproic acid-related alopecia: A systematic review and meta-analysis.

Seizure 2019 Apr 5;69:61-69. Epub 2019 Apr 5.

Department of Neurology, West China Hospital, Sichuan University, No. 37, Guo Xue Xiang, Chengdu, 610041, Sichuan Province, China. Electronic address:

Purpose: We systematically reviewed studies to provide current evidence about the incidence and risk of alopecia in patients undergoing valproic acid (VPA) therapy.

Methods: We retrieved relevant publications and gathered data on alopecia in patients taking VPA and other drugs from prospective studies.

Results: Twenty-five articles met the inclusion criteria, and the overall incidence of alopecia in patients receiving VPA therapy was 11% (95% confidence interval (CI): 0. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10591311193005
Publisher Site
http://dx.doi.org/10.1016/j.seizure.2019.04.003DOI Listing
April 2019
2 Reads

Localization value of ictal turning prone.

Seizure 2018 Dec 7;69:57-60. Epub 2018 Dec 7.

Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, United States.

Purpose: Ictal semiology complements ictal EEG in identifying the likely epileptogenic zone. Ictal turning prone (ITP) with body turning of 90 ° or more can be seen with frontal lobe epilepsies. The aim of our study was to evaluate the localizing value of ITP in a general population of patients undergoing long term video-EEG monitoring. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.seizure.2018.11.003DOI Listing
December 2018
1 Read

Underutilization of epilepsy surgery in ASEAN countries.

Seizure 2019 Apr 4;69:51-56. Epub 2019 Apr 4.

Division of Neurology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

Purpose: This survey was performed to determine the availability of epilepsy surgery, and understand the limiting factors to epilepsy surgery in ASEAN countries with total of 640 million population.

Method: A cross-sectional survey was completed by national representatives in all ASEAN countries (Brunei, Cambodia, East Timor, Indonesia, Laos, Malaysia, Myanmar, Philippines, Singapore, Thailand, and Vietnam).

Results: Overall facilities for initial epilepsy pre-surgical evaluation are available in most countries, but further non-invasive and invasive investigations are limited. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.seizure.2019.04.002DOI Listing

A study of perfusion changes with Insula Epilepsy using SPECT.

Seizure 2019 Mar 28;69:44-50. Epub 2019 Mar 28.

Epilepsy Unit, Department of Neurology, Westmead Hospital and Children's Hospital at Westmead, Hawkesbury Rd, Westmead, NSW, 2145, Australia; Westmead Clinical School, University of Sydney, Hawkesbury Rd, Westmead, NSW, 2145, Australia.

Purpose: The non-invasive localisation of insular lobe epilepsy is a challenge. We aimed to determine if ictal SPECT is a reliable adjunctive test in insular cases and to explore its role in the tailoring of intracranial strategies.

Method: From a dataset of patients who underwent SEEG between December 2012 and December 2016, we collected patients with focal insular onset epilepsy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.seizure.2019.03.021DOI Listing
March 2019
1 Read
2.059 Impact Factor

Initiating the ketogenic diet in infants with treatment refractory epilepsy while maintaining a breast milk diet.

Seizure 2019 Mar 26;69:41-43. Epub 2019 Mar 26.

Children's Mercy Hospital, Division of Neurology, Kansas City, United States.

Purpose: The ketogenic diet has been found to be safe and effective in the treatment of drug resistant epilepsy in childhood. The age range of children undergoing this treatment has steadily been going down. There is strong evidence that it is a safe alternative in infants with drug resistant seizures. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.seizure.2019.03.017DOI Listing
March 2019
1 Read

Surgical resection of cavernous angioma located within eloquent brain areas: International survey of the practical management among 19 specialized centers.

Seizure 2019 Mar 28;69:31-40. Epub 2019 Mar 28.

Department of Neurosurgery, Sainte-Anne Hospital, Paris, France; Paris Descartes University, Sorbonne Paris Cité, Paris, France; UMR 1266 INSERM, IMA-BRAIN, Institute of Psychiatry and Neurosciences of Paris, Paris, France. Electronic address:

Purpose: The practical management of cavernous angioma located within eloquent brain area before, during and after surgical resection is poorly documented. We assessed the practical pre-operative, intra-operative, and post-operative management of cavernous angioma located within eloquent brain area.

Method: An online survey composed of 61 items was sent to 26 centers to establish a multicenter international retrospective cohort of adult patients who underwent a surgical resection as the first-line treatment of a supratentorial cavernous angioma located within or close to eloquent brain area. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.seizure.2019.03.022DOI Listing
March 2019
3 Reads

Reflex seizure triggering: Learning about seizure producing systems.

Seizure 2019 Mar 28;69:25-30. Epub 2019 Mar 28.

National Institute of Clinical Neurosciences, Budapest, Hungary.

Aim: We aim to study the mechanism of reflex seizure triggering in close link with the system-epilepsy concept.

Method: We use data and theories presented in the literature and scrutinize a few illustrative cases.

Conclusions: The prerequisite of seizure triggering is an epilepsy-prone brain network. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.seizure.2019.03.019DOI Listing

Intravenous use of valproic acid in status epilepticus is associated with high risk of hyperammonemia.

Seizure 2019 Mar 28;69:20-24. Epub 2019 Mar 28.

Department of Perioperative and Intensive Care, County Hospital Ryhov, Jönköping, Sweden.

Purpose: The aim of the study was to examine the frequency of hyperammonemia secondary to valproic acid treatment in status epilepticus and to describe the characteristics of the patients.

Methods: All patients with established status epilepticus during 2014 to 2016 at Ryhov County Hospital were identified in a retrospective case series. Clinical and laboratory findings were collected from electronic medical files and the Metavision database at the intensive care unit (ICU). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.seizure.2019.03.020DOI Listing
March 2019
1 Read

Association of temporal lobe epilepsy with gambling disorder in a patient with mild intellectual disability and autism spectrum disorder.

Seizure 2019 Mar 28;69:17-19. Epub 2019 Mar 28.

Leicestershire Partnership Trust, Agnes Unit, 400 Anstey Lane, Leicester LE7 7GL, UK; George Davies Centre, 15 Lancaster Rd, Leicester, LE1 7HA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.seizure.2019.03.023DOI Listing
March 2019
1 Read

Interictal electrocardiographic alternations in patients with drug-resistant epilepsy.

Seizure 2018 Jul 9;69:7-10. Epub 2018 Jul 9.

Cardiopulmonary Research Center, Shaheed Beheshti University of Medical Science, Tehran, Iran.

Purpose: Previous studies suggested the possible role of autonomic dysfunction in sudden unexpected death in epilepsy (SUDEP). The aim of this study is to assess the interictal ECG alternations especially heart rate variability (HRV), as a marker of autonomic dysfunction, in patients with drug-resistant epilepsy and determine the effect of epilepsy type and duration, seizure frequency and anti-epileptic drugs (AEDs) on ECG findings.

Methods: In this comparative cross-sectional study, the interictal ECG parameters of 64 consecutive patients with drug-resistant epilepsy and the same number of age and sex-matched controls were analyzed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.seizure.2018.07.002DOI Listing
July 2018
2 Reads

Risk factors for the development of seizures after cranioplasty in patients that sustained traumatic brain injury: A systematic review.

Seizure 2019 Mar 21;69:11-16. Epub 2019 Mar 21.

Department of Neurosurgery, University Hospital of Wales, Cardiff, UK; Neuroscience and Mental Health Research Institute (NMHRI), School of Medicine, Cardiff University, UK.

Decompressive craniectomy (DC) is used for the treatment of raised intracranial pressure secondary to traumatic brain injury. Cranioplasty is a reconstructive procedure that restores the structural integrity of the skull following (DC). Seizures are a recognised complication of cranioplasty but its incidence and risk factors in TBI patients are unclear. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.seizure.2019.03.014DOI Listing
March 2019
4 Reads

Does the age of seizure onset relate to menarche and does it matter?

Seizure 2019 Mar 26;69:1-6. Epub 2019 Mar 26.

Harvard Neuroendocrine Unit, Beth Israel Deaconess Medical Center, Boston, MA 02481, USA.

Purpose: To determine whether there is a relationship between the age of seizure onset and the age of menarche.

Methods: 1144 women with epilepsy (WWE) in the community, ages 18-47 years, provided web-based survey data. We compared the frequencies of the individual differences between their ages of seizure onset and menarche to each other and chance. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.seizure.2019.03.018DOI Listing
March 2019
2 Reads

Lafora disease in a Malaysian with a rare mutation in the EPM2A gene.

Seizure 2019 Mar 25;67:78-81. Epub 2019 Mar 25.

Department of Neurology, Hospital Kuala Lumpur, Ministry of Health Malaysia, Malaysia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.seizure.2019.03.012DOI Listing
March 2019
1 Read
2.059 Impact Factor

Computation of antiepileptic drug retention rates in the presence of a competing risk.

Seizure 2019 Mar 30. Epub 2019 Mar 30.

Department of Neurology, Leiden University Medical Center, Leiden, the Netherlands; Department of Neurology, Haaglanden Medical Center, The Hague, the Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.seizure.2019.03.001DOI Listing
March 2019
1 Read

Familial adult myoclonic epilepsy: A new expansion repeats disorder.

Seizure 2019 Mar 19;67:73-77. Epub 2019 Mar 19.

Pediatric Neurology and Muscular Diseases Unit, DINOGMI-Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, IRCCS "G. Gaslini" Institute, Genova, Italy. Electronic address:

Familial adult myoclonic epilepsy (FAME), also described with different acronyms (ADCME, BAFME, FEME, FCTE and others), is a high-penetrant autosomal dominant condition featuring cortical hand tremors, myoclonic jerks, and occasional/rare convulsive seizures. Prevalence is unknown since this condition is often under-recognized, but it is estimated to be less than 1/35,000. The disease usually starts in the second decade of life and has been genetically associated with at least 4 different loci (8q24, 2p11. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.seizure.2019.03.009DOI Listing
March 2019
1 Read

MEF2C-related epilepsy: Delineating the phenotypic spectrum from a novel mutation and literature review.

Seizure 2019 Mar 22. Epub 2019 Mar 22.

Division of Neurology, Department of Paediatrics, The Hospital for Sick Children, Toronto, ON, Canada.

Purpose: MEF2C-related epilepsy has been poorly described in the literature, despite a consistent MEF2C haploinsufficiency phenotype characterized by severe language impairment and motor delay (MIM# 613443). We aimed to delineate the spectrum of electroclinical manifestations of MEF2C-related epilepsy from an illustrative case and literature review.

Methods: A retrospective chart review of our case was performed followed by a literature review on PubMed and OMIM. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.seizure.2019.03.015DOI Listing
March 2019
2 Reads

Editorial: Outcome of ambulatory video-EEG monitoring in a ˜10,000 patient nationwide cohort.

Authors:
William O Tatum

Seizure 2019 Mar;66:112-113

Mayo Clinic College of Medicine, Department of Neurology and Neurosurgery, Mayo Clinic, 4500 San Pablo Road, Mangurian Building, 4th Floor, Jacksonville, FL 32224 USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.seizure.2019.02.016DOI Listing

Outcome of ambulatory video-EEG monitoring in a ˜10,000 patient nationwide cohort.

Seizure 2019 Mar;66:104-111

Epilepsy Center, The George Washington University School of Medicine and Health Sciences, Washington, DC, United States.

Purpose: We evaluate outcome of in-home diagnostic ambulatory video-EEG monitoring (AVEM) performed on a nationwide cohort of patients over one calendar year, and we compare our findings with outcomes of inpatient adult and pediatric VEM performed during the same year at two academic epilepsy centers.

Methods: This is a retrospective cohort study. We obtained AVEM outcome data from an independent ambulatory-EEG testing facility. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.seizure.2019.01.018DOI Listing
March 2019
3 Reads

Reply to 'Computation of antiepileptic drug retention rates in the presence of a competing risk'.

Authors:
Johan Zelano

Seizure 2019 Mar 19. Epub 2019 Mar 19.

Department of Clinical Neuroscience, Gothenburg University, and Department of Neurology, Sahlgrenska University Hospital, Blå stråket 7, 41345 Gothenburg, Sweden. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.seizure.2019.03.011DOI Listing

Short burst Clobazam dosing at discharge from VEEG evaluation reduces re-presentation with seizures.

Seizure 2019 Mar 16;67:61-64. Epub 2019 Mar 16.

Mater Advanced Epilepsy Unit, Mater Hospital, Brisbane, Australia.

Purpose: Recurrent seizures and status epilepticus after medication reduction for inpatient Video Electroencephalograph (VEEG) monitoring is a well-known complication of this investigation. In the literature this is reported to occur at a rate of approximately 3-7%. We review the use of short burst Clobazam dosing on discharge from the Epilepsy monitoring unit (EMU) to determine if this might reduce rates of representation with seizures. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.seizure.2019.03.008DOI Listing
March 2019
1 Read

Migrating focal seizures in Autosomal Dominant Sleep-related Hypermotor Epilepsy with KCNT1 mutation.

Seizure 2019 Mar 7;67:57-60. Epub 2019 Mar 7.

Epilepsy Centre, Unit of Child Neuropsychiatry, Department of Medical and Surgical Neurosciences and Rehabilitation, IRCCS Giannina Gaslini Institute, Genoa, Italy. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.seizure.2019.02.019DOI Listing
March 2019
1 Read

Recent practice patterns in diagnostic procedures anticonvulsants, and antibiotics for children hospitalized with febrile seizure.

Seizure 2019 Mar 15;67:52-56. Epub 2019 Mar 15.

Department of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo, Japan.

Purpose This study investigated clinical practice patterns for admissions due to FS at a national level. Method Discharge records were extracted for patients with FS aged < 6 years for the years 2010-16 using national inpatient database in Japan. We ascertained antiepileptic drug use, diagnostic procedures, healthcare costs, and length of hospital stays (LOS), using mixed effect linear or logistic regression models. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.seizure.2019.03.007DOI Listing
March 2019
1 Read

Reliability of reported peri-ictal behavior to identify psychogenic nonepileptic seizures.

Seizure 2019 Mar 5;67:45-51. Epub 2019 Mar 5.

Department of Neurology, David Geffen School of Medicine at the University of California, Los Angeles (UCLA), Los Angeles, CA, USA.

Purpose: Differentiating psychogenic non-epileptic seizures (PNES) from epileptic seizures (ES) can be difficult, even when expert clinicians have video recordings of seizures. Moreover, witnesses who are not trained observers may provide descriptions that differ from the expert clinicians', which often raises concern about whether the patient has both ES and PNES. As such, quantitative, evidence-based tools to help differentiate ES from PNES based on patients' and witnesses' descriptions of seizures may assist in the early, accurate diagnosis of patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.seizure.2019.02.021DOI Listing
March 2019
4 Reads

Corrigendum to "Simultaneous scalp EEG improves seizure lateralization during unilateral intracranial EEG evaluation in temporal lobe epilepsy" [Seizure 64 January (2019) 8-15].

Seizure 2019 Mar 14. Epub 2019 Mar 14.

Department of Neurology, Baylor College of Medicine, Houston, TX, 77030, United States; Neurology Care Line, VA Houston Medical Center, Houston, TX, 77030, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.seizure.2019.03.002DOI Listing

Impact of withdrawal of antiepileptic medication on the duration of focal onset seizures.

Seizure 2019 Mar 8;67:40-44. Epub 2019 Mar 8.

Epilepsy Center, Department of Neurology, University Hospital, LMU Munich, Munich, Germany.

Purpose: To systematically evaluate the duration of focal onset seizures under medication withdrawal as a function of drug half-life.

Methods: Adults with drug resistant focal epilepsy and invasive electroencephalographic (iEEG) recording between 01/2006 and 06/2016 (n = 128) were identified. Patients with multifocal or unknown epileptic foci were excluded, as well as subclinical seizures, isolated auras, or status epileptic. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.seizure.2019.03.005DOI Listing
March 2019
2 Reads

Improving post-hypoxic myoclonus using cannabidiol.

Seizure 2019 Mar 6;67:38-39. Epub 2019 Mar 6.

Epilepsy Center Frankfurt Rhine-Main, Center of Neurology and Neurosurgery, Goethe University Frankfurt, Frankfurt am Main, Germany; LOEWE Center for Personalized Translational Epilepsy Research (CePTER), Goethe University Frankfurt, Frankfurt am Main, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.seizure.2019.03.003DOI Listing

Very long-term outcome in resected and non-resected patients with temporal lobe epilepsy with medial temporal lobe sclerosis: A multiple case-study.

Seizure 2019 Feb 24;67:30-37. Epub 2019 Feb 24.

Bethel Epilepsy Center, Bielefeld, Germany; Laboratory Krone, Bad Salzuflen, Germany.

Purpose: To investigate the very long-term (i.e., ≥15 years) seizure, cognitive and psycho-social outcomes in resected patients (RP) with TLE compared to control patients not having undergone epilepsy surgery. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.seizure.2019.02.015DOI Listing
February 2019
5 Reads

Akinetopsia with achromatopsia due to focal epilepsy.

Seizure 2019 Mar 6;67:27-29. Epub 2019 Mar 6.

Department of Neurology, National Hospital Organization Higashi-ohmi General Medical Center, Shiga, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.seizure.2019.03.004DOI Listing
March 2019
1 Read

Sociocultural representations of epilepsy in the Central African Republic: A door-to-door survey.

Seizure 2019 Feb 27;67:23-26. Epub 2019 Feb 27.

INSERM, U1094,Tropical Neuroepidemiology, Limoges, France; Univ. Limoges, UMR_S 1094, Tropical Neuroepidemiology, Institute of Neuroepidemiology and Tropical Neurology, CNRS FR 3503 GEIST, F-87000, Limoges, France.

Purpose: To describe sociocultural representations of epilepsy in a sub-Saharan Africa rural community using a population-based approach.

Method: A cross-sectional door-to-door survey was underway on a rural community of the Central African Republic in 2015. A two-stage stratified sampling was performed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.seizure.2019.02.018DOI Listing
February 2019

Plasma concentration and clinical effects of perampanel-The Kork experience.

Seizure 2019 Feb 28;67:18-22. Epub 2019 Feb 28.

Epilepsiezentrum Kork, Landstrasse 1, 77694, Kehl-Kork, Germany.

Purpose: To investigate the correlation between steady-state plasma concentrations of perampanel (PER) with efficacy and tolerability in adult patients with difficult-to-treat epilepsy.

Methods: PER plasma concentrations were assessed at steady-state conditions in 92 adult patients (57% female, 43% male, mean age 39,5 years, age range 20-73 years). All patients had been treated with PER at a stable dose for at least 3 weeks. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.seizure.2019.02.022DOI Listing
February 2019

Novel epilepsy phenotype associated to a known SCN8A mutation.

Seizure 2019 Mar 4;67:15-17. Epub 2019 Mar 4.

Scientific Institute, IRCCS E. Medea, Clinical Neurophysiology Unit, Bosisio Parini, LC, Italy.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10591311183082
Publisher Site
http://dx.doi.org/10.1016/j.seizure.2019.01.017DOI Listing
March 2019
3 Reads

Comparing long-term outcomes of epilepsy patients from a single-visit outreach clinic with a conventional epilepsy clinic: A cross-sectional observational study from India.

Seizure 2019 Mar 2;67:5-10. Epub 2019 Mar 2.

Epilepsy Educators, India.

Purpose: To compare long-term treatment outcomes in epilepsy patients from a single-visit outreach clinic on the Lifeline Express (LLE) with a conventional hospital (AIIMS) based epilepsy clinic in India.

Methods: Using a cross-sectional observational study design, consecutive epilepsy patients from fifteen LLE clinics conducted from 2009 to 2014 were compared to epilepsy patients registered in the same duration at the AIIMS epilepsy clinic. The primary outcome was to determine if patients were still taking AEDs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.seizure.2019.02.008DOI Listing

Ryanodine receptor 2 (RYR2) mutation: A potentially novel neurocardiac calcium channelopathy manifesting as primary generalised epilepsy.

Seizure 2019 Feb 22;67:11-14. Epub 2019 Feb 22.

Department of Neurology, Mater Misericordiae University Hospital, Eccles Street, Dublin 7, Ireland.

Purpose: Ryanodine receptor 2 (RYR2) mutation is well-established in the aetiology of an inherited cardiac disorder known as catecholaminergic polymorphic ventricular tachycardia (CPVT). The RYR2 receptor is expressed in cardiomyocytes, and also in the hippocampus. The RYR2 mutation has not been reported as a potential cause of adult-onset genetic generalised epilepsy (GGE). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.seizure.2019.02.017DOI Listing
February 2019
1 Read

The effect of perampanel on aggression and depression in patients with epilepsy: A short-term prospective study.

Seizure 2019 Feb 21;67:1-4. Epub 2019 Feb 21.

Neuropsychiatric Department, Aichi Medical University, Japan.

Purpose: Using specialized tools, we assessed patients receiving perampanel (PER) to investigate its effects on aggression and depression, as well as the impact of other concomitant antiepileptic drugs (AEDs) on those conditions.

Method: Seventy-seven patients with epilepsy were initially enrolled, then examined at entry and 12 weeks later (endpoint). At both examinations, assessments were performed with the Buss Perry Aggression Questionnaire (BAQ) and Neurological Disorders Depression Inventory for Epilepsy (NDDI-E). Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10591311183081
Publisher Site
http://dx.doi.org/10.1016/j.seizure.2019.02.009DOI Listing
February 2019
8 Reads

Association of cutaneous adverse drug reactions due to antiepileptic drugs with HLA alleles in a North Indian population.

Seizure 2019 Mar 20;66:99-103. Epub 2019 Feb 20.

All India Institute of Medical Sciences, Neurology, Neurosciences Centre, Room no-705, 7th floor, 110029, New Delhi, India. Electronic address:

Purpose: Aromatic antiepileptic drugs (AEDs) are frequently implicated in cutaneous adverse drug reactions (cADRs), a few of which are associated with certain human leukocyte antigen (HLA) alleles in some populations. We aimed to find HLA-associations with AED-related cADRs among North Indians.

Methods: North Indian subjects with cADR due to an AED, and those who were AED-tolerant were recruited as cases and controls, respectively. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.seizure.2019.02.011DOI Listing
March 2019
9 Reads

Depression and quality of life in patients with epilepsy in Northwest Greece.

Seizure 2019 Mar 20;66:93-98. Epub 2019 Feb 20.

Department of Neurology, University of Ioannina, University Hospital of Ioannina, Ioannina, 45110, Greece. Electronic address:

Purpose: The purpose of the present study was to compare depression and QoL between patients with epilepsy and healthy controls, evaluating potentially related factors to depression and QoL in patients with epilepsy in Northwest Greece.

Methods: A case study was conducted in adult patients with epilepsy followed up at the University Hospital of Ioannina and in healthy controls. The Patient Health Questionnaire (PHQ-9) for depression's severity evaluation, the WHOQOL-BREF questionnaire for the QoL estimation and the Adverse Event Profile (AEP) questionnaire for the Antiepileptic Drugs (AEDs) adverse effects assessment were used. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10591311183078
Publisher Site
http://dx.doi.org/10.1016/j.seizure.2019.02.012DOI Listing
March 2019
12 Reads