7,874 results match your criteria Sedative Hypnotic Anxiolytic Use Disorders


Pharmacological treatments for generalised anxiety disorder: a systematic review and network meta-analysis.

Lancet 2019 02 31;393(10173):768-777. Epub 2019 Jan 31.

Institute for Clinical Trials, University College London, London UK. Electronic address:

Background: Generalised anxiety disorder is a disease that can be associated with substantial dysfunction. Pharmacological treatment is often the first choice for clinicians because of the cost and resource constraints of psychological alternatives, but there is a paucity of comparative information for the multiple available drug choices.

Methods: A systematic review and network meta-analysis was performed on randomised trials in adult outpatients with generalised anxiety disorder identified from MEDLINE, Web of Science, Cochrane Library, ClinicalTrials. Read More

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http://dx.doi.org/10.1016/S0140-6736(18)31793-8DOI Listing
February 2019
3 Reads

Tolerability of Midazolam to treat acute agitation in elderly demented patients: A systematic review.

J Clin Pharm Ther 2019 Apr 21;44(2):143-147. Epub 2019 Jan 21.

Department of Pharmacy, University Hospital of Amiens-Picardie, Amiens, France.

What Is Known And Objective: Behavioural disorders are difficult to manage in elderly demented patients because of the lack of appropriate drugs or difficulties surrounding the route of administration. The tolerability of Midazolam is well described in the emergency management of agitation for young patients, when administered intramuscularly or intravenously. However, very little data are available on the use of oral Midazolam for this indication and in the elderly population. Read More

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http://dx.doi.org/10.1111/jcpt.12785DOI Listing
April 2019
1 Read

Application of sedation-agitation scale in conscious sedation before bronchoscopy in children.

Medicine (Baltimore) 2019 Jan;98(1):e14035

Department of Pediatric Pulmonology and Immunology, West China Second University Hospital of Sichuan University.

This retrospective study investigated the application of the sedation-agitation scale (SAS) in pediatric bronchoscopy by observing its effects on sedative dosages and adverse reactions.Children who underwent sedation before bronchoscopy, during the period from January 2014 to June 2017, were divided into control and SAS groups. Patients in the control group were administered a single dose of 0. Read More

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http://dx.doi.org/10.1097/MD.0000000000014035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344143PMC
January 2019
3 Reads

Generalized Convulsive Status Epilepticus Secondary to Jarisch-Herxheimer Reaction in Neurosyphilis: A Case Report and Literature Review.

Neurologist 2019 Jan;24(1):29-32

Department of Neurology, Health Sciences Center, Federal University of Santa Maria, Rio Grande do Sul, Brazil.

Introduction: Jarisch-Herxheimer reaction (JHR) is defined as a transient immunologic reaction, classically seen in patients during syphilis treatment. JHR is a rare cause of status epilepticus (SE) in neurosyphilis. We describe a case of generalized convulsive SE (GCSE) probably secondary to JHR in a patient with neurosyphilis. Read More

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http://dx.doi.org/10.1097/NRL.0000000000000219DOI Listing
January 2019
5 Reads

De novo absence status epilepticus in three paediatric patients: a new idiopathic epilepsy syndrome?

Epileptic Disord 2018 Dec;20(6):502-507

Hospital de Pediatría "La madre y el Niño", Formosa, Argentina.

Absence status epilepticus (ASE) is a prolonged generalized absence seizure that usually lasts for hours and can even last for days. The main symptom is the altered content of consciousness while the patient may be alert and partly responsive. We describe the electroclinical features, treatment, and evolution of three paediatric patients with de novo ASE with an excellent response to valproic acid (VPA). Read More

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http://dx.doi.org/10.1684/epd.2018.1008DOI Listing
December 2018
3 Reads

Determination of emerging chlorinated byproducts of diazepam in drinking water.

Chemosphere 2019 Mar 15;218:223-231. Epub 2018 Nov 15.

Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China; Beijing Key Laboratory of Diagnostic and Traceability Technologies for Food Poisoning, Beijing Center for Disease Prevention and Control, Beijing, 100013, China. Electronic address:

Diazepam (DZP) is often found in source water and drinking water at dozens of nanograms per liter levels. The transformation of DZP in water chlorination disinfection process has aroused new concern because the toxic disinfection byproducts (DBPs) might be produced. However, the DBPs of DZP have not been fully identified, and their occurrence levels in drinking water have not been reported. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2018.11.076DOI Listing
March 2019
2 Reads

Patients' experiences attributed to the use of Passiflora incarnata: A qualitative, phenomenological study.

J Ethnopharmacol 2019 Mar 14;231:295-301. Epub 2018 Nov 14.

Institute for Complementary and Integrative Medicine, University Hospital Zurich, Switzerland and University of Zurich, Switzerland; Institute for Social Medicine, Epidemiology and Health Economics, Charité - Universitätsmedizin Berlin, Germany; Center for Integrative Medicine, University of Maryland, School of Medicine, Baltimore, MD, USA.

Ethnopharmacological Relevance: Passiflora incarnata Linnaeus (Passiflora incarnata) was established as a medicinal plant in Europe in the middle of the 19th century. Since then, it has been used for the treatment of anxiety, sleep disorders and restlessness in Western European phytotherapy. This study provides insights into how Passiflora incarnata is currently used and experienced as a medicinal plant by German-speaking patients in Switzerland. Read More

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http://dx.doi.org/10.1016/j.jep.2018.11.022DOI Listing
March 2019
22 Reads

Neuroprotective action of diazepam at very low and moderate doses in Alzheimer's disease model rats.

Neuropharmacology 2019 01 5;144:319-326. Epub 2018 Nov 5.

Department of Pharmacology, Faculty of Medicine, University of Latvia, 1 Jelgavas St., LV 1004, Riga, Latvia.

Early manifestations of Alzheimer's disease (AD) include neuroinflammation, disrupted neurotransmission and cognitive deficits. Impairment of the GABAergic system is essentially involved in the pathogenesis of AD. Traditionally, agonists of GABA receptors at doses above 1 mg/kg are known to possess memory impairing effects. Read More

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http://dx.doi.org/10.1016/j.neuropharm.2018.11.003DOI Listing
January 2019
16 Reads

Diazepam as attenuator of pain induced by dentin hypersensitivity in rats exposed to stress.

Arch Oral Biol 2019 Jan 29;97:165-169. Epub 2018 Oct 29.

Graduate Program in Dentistry, Paulista University - UNIP, Av. Dr. Bacelar, 1212, Vila Clementino, 04026-002, São Paulo, SP, Brazil. Electronic address:

The pain in dentin hypersensitivity (DH) has distinct sensory and emotional origins, with variations that occur in different intensities for each individual. The aim of this study is to evaluate the effects of diazepam in the attenuation of the pain induced by DH.

Design: Fifty male Wistar rats were divided into five groups: control group received water ad libitum (C); stress group received water ad libitum plus stress (S); DH induced by erosion challenge with isotonic solution ad libitum (G); DH and stress (GS); and DH, stress and diazepam (GSD) groups. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2018.10.033DOI Listing
January 2019

Gamma aminobutyric acid (GABA) receptor agonists for acute stroke.

Cochrane Database Syst Rev 2018 10 30;10:CD009622. Epub 2018 Oct 30.

Department of Neurology, Xuanwu Hospital, Capital Medical University, Changchun Street 45, Beijing, China, 100053.

Background: Gamma aminobutyric acid (GABA) receptor agonists have been shown to have a neuroprotectant effect in reducing infarct size and improving functional outcome in animal models of cerebrovascular disease. However, the sedative effects of GABA receptor agonists have limited their wider application in people with acute stroke, due to the potential risk of stupor. This is an update of a Cochrane Review first published in 2013, and previously updated in 2014 and 2016. Read More

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http://doi.wiley.com/10.1002/14651858.CD009622.pub5
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http://dx.doi.org/10.1002/14651858.CD009622.pub5DOI Listing
October 2018
7 Reads

A Retrospective Study of Dosing Weight and Outcomes for One Pediatric Dental Sedation Regimen.

Pediatr Dent 2018 Sep;40(5):346-351

Assistant professor, Department of Research and Graduate Programs, School of Dentistry, University of Missouri, Kansas City, Mo., USA.

The purpose of this study was to assess the use of a dosing scalar for association with the success of procedural sedation in pediatric dentistry. This cross-sectional, retrospective study assessed healthy two- to 12-year-olds who received an elixir of midazolam (0.3 mg/kg), meperidine (1. Read More

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September 2018
6 Reads

Prevalence of burnout, depression and job satisfaction among French senior and resident radiation oncologists.

Cancer Radiother 2018 Dec 19;22(8):784-789. Epub 2018 Oct 19.

Département de radiothérapie, centre Henri-Becquerel, 1, rue d'Amiens, 76000 Rouen, France; CNRS, Laboratoire QuantIF, EA4108-Litis, FR UMR 3638, 1, rue d'Amiens, 76000 Rouen, France; Société française des jeunes radiothérapeutes oncologues (SFjRO), centre Antoine-Béclère, 47, rue de la Colonie, 75013 Paris, France.

Purpose: Cancer caregivers are at high risk of burn-out, with potential severe consequences on professionals' health and on patients' care. We have investigated the prevalence of burn-out and its impact in terms of psychological morbidity among French radiation oncologists.

Methods And Materials: An anonymous online questionnaire was advertised in all French senior radiation oncologists and residents, including demographical data, job-related stress factors, drug use, the Maslach Burn-out Inventory (MBI) and the General Health Questionnaire (GHQ-12). Read More

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http://dx.doi.org/10.1016/j.canrad.2018.02.005DOI Listing
December 2018
3 Reads

Essential Oil and Linalool Counteract Social Aversion Induced by Social Defeat.

Molecules 2018 Oct 19;23(10). Epub 2018 Oct 19.

Departament of Psicobiology, University of Valencia, Avda. Blasco Ibáñez, 21, 46010 Valencia, Spain.

Many vegetable extracts, essential oils, and their main constituents are active on the Central Nervous System (CNS). In fact, they have been used as sedatives, hypnotics, or tranquilizers for their activity in treating CNS disorders. In this research, we studied the possible activities of (LA) essential oil and of its main constituent, linalool, as anti-stress compounds on anxiety and social interaction and their in vitro effects on proteins (pERK and PKA) involved in the transmission of the signal. Read More

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http://www.mdpi.com/1420-3049/23/10/2694
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http://dx.doi.org/10.3390/molecules23102694DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222471PMC
October 2018
19 Reads

The leaves of Crataeva nurvala Buch-Ham. modulate locomotor and anxiety behaviors possibly through GABAergic system.

BMC Complement Altern Med 2018 Oct 19;18(1):283. Epub 2018 Oct 19.

Designated Reference Institute for Chemical Measurement (DRiCM), Bangladesh Council of Scientific & Industrial Research, Dhaka, 1205, Bangladesh.

Background: Crataeva nurvala Buch-Hum is an indigenous herb, extensively used in traditional medicines of the South Asian countries to treat inflammation, rheumatic fever, gastric irritation, and constipation. Despite this wide range of uses, very little information is known regarding its effects on the central nervous system (CNS). Therefore, this study evaluated the neuropharmacological properties of methanolic extract of Crataeva nurvala leaves (MECN) using a number of behavioral models in animals. Read More

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https://bmccomplementalternmed.biomedcentral.com/articles/10
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http://dx.doi.org/10.1186/s12906-018-2338-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6194725PMC
October 2018
19 Reads
2.020 Impact Factor

A clinical study to evaluate the cardiopulmonary characteristics of two different anaesthetic protocols for immobilization of healthy chimpanzees (Pan troglodytes).

Vet Anaesth Analg 2018 Nov 23;45(6):794-801. Epub 2018 Aug 23.

School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington, UK. Electronic address:

Objective: To characterize the cardiopulmonary characteristics of two different anaesthetic protocols (tiletamine/zolazepam ± medetomidine) and their suitability for the immobilization of healthy chimpanzees undergoing cardiac assessment.

Study Design: Prospective, clinical, longitudinal study.

Animals: Six chimpanzees (Pan troglodytes) aged 4-16 years weighing 19. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S14672987183018
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http://dx.doi.org/10.1016/j.vaa.2018.06.015DOI Listing
November 2018
27 Reads

Predictors of resistant alcohol withdrawal (RAW): A retrospective case-control study.

Drug Alcohol Depend 2018 11 2;192:303-308. Epub 2018 Oct 2.

Department of Pharmacy, UPMC Presbyterian, 200 Lothrop Street, Pittsburgh, PA 15213, United States; Department of Pharmacy and Therapeutics, University of Pittsburgh School of Pharmacy, 3501 Terrace St, Pittsburgh, PA 15213, United States.

Background: Benzodiazepine-resistant alcohol withdrawal (RAW), defined by a requirement of ≥ 40 mg of diazepam in 1 h, represents a severe form of withdrawal without predictive parameters. This study was designed to identify risk factors associated with RAW versus withdrawal without benzodiazepine resistance (nRAW).

Methods: A retrospective cohort of adults with severe alcohol withdrawal were screened. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03768716183064
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http://dx.doi.org/10.1016/j.drugalcdep.2018.08.017DOI Listing
November 2018
35 Reads
3.420 Impact Factor

Aqueous Extract of Semen Exerts Anxiolytic Effects during Nicotine Withdrawal via Improvement of Amygdaloid CRF/CRF1R Signaling.

Evid Based Complement Alternat Med 2018 2;2018:2419183. Epub 2018 Sep 2.

Medical Research Center, College of Oriental Medicine, Daegu Haany University, Gyeongsan-si 38610, Republic of Korea.

Anxiety during nicotine withdrawal (NicW) is a key risk factor for smoking relapse. Semen (SZS), which is a prototypical hypnotic-sedative herb in Oriental medicine, has been clinically used to treat insomnia and general anxiety disorders for thousands of years. Thus, the present study evaluated the effects of the aqueous extract of SZS (AESZS) on NicW-induced anxiety in male rats that received subcutaneous administrations of nicotine (Nic) (0. Read More

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http://dx.doi.org/10.1155/2018/2419183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6139233PMC
September 2018
3 Reads

TP003 is a non-selective benzodiazepine site agonist that induces anxiolysis via α2GABA receptors.

Neuropharmacology 2018 12 18;143:71-78. Epub 2018 Sep 18.

Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, CH-8057, Zurich, Switzerland; Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology (ETH) Zurich, Vladimir Prelog Weg 4, CH-8093, Zurich, Switzerland; Drug Discovery Network Zurich (DDNZ), Winterthurerstrasse 190, CH-8057, Zurich, Switzerland. Electronic address:

Benzodiazepines (BDZ), which potentiate the action of GABA at four subtypes of GABA receptors (α1, α2, α3, and α5GABARs), are highly effective against anxiety disorders, but also cause severe side effects greatly limiting their clinical application. Both, preclinical studies in genetically engineered mice, and preclinical and clinical trials with subtype-selective compounds indicate that undesired effects can in principle be avoided by targeting specific GABAR subtypes. While there is general consensus that activity at α1GABARs should be avoided, controversy exists as to whether α2 or α3GABARs need to be targeted for anxiolysis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00283908183067
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http://dx.doi.org/10.1016/j.neuropharm.2018.09.026DOI Listing
December 2018
10 Reads

The anxiolytic-like effects of estazolam on a PTSD animal model.

Psychiatry Res 2018 11 29;269:529-535. Epub 2018 Aug 29.

Department of Oncology, The Affiliated Jiangyin Hospital of Southeast University Medical College, Jiangyin, Jiangsu 214400, PR China. Electronic address:

Post-traumatic stress disorder (PTSD) is a serious psychiatric disorder. Estazolam has been shown to produce anxiolytic-, hypnotic-, amnestic-, and sedative-like effects. However, few studies are concerned about its anti-PTSD-like effects. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01651781183019
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http://dx.doi.org/10.1016/j.psychres.2018.08.118DOI Listing
November 2018
20 Reads

Pharmacological Evaluation of L. and L., Medicinal Plants Used to Treat Anxiety and Insomnia in Colombian Caribbean Coast.

Evid Based Complement Alternat Med 2018 7;2018:5921514. Epub 2018 Aug 7.

Biological Evaluation of Promising Substances Group, Faculty of Pharmaceutical Sciences, University of Cartagena, Cartagena 130015, Colombia.

Anxiety disorders are highly prevalent, chronic, and disabling conditions that impose enormous health and economic costs both on individuals and on society. Medicinal plants are an invaluable source of bioactive metabolites that can be useful as new pharmacological treatment. Teas from and are employed by Colombian populations to treat stress and insomnia. Read More

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http://dx.doi.org/10.1155/2018/5921514DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6106973PMC
August 2018
18 Reads

Alprazolam and Zolpidem in Skeletal Tissue of Decomposed Body Confirms Exposure.

J Forensic Sci 2019 Mar 21;64(2):643-646. Epub 2018 Aug 21.

Laboratory of Forensic Medicine & Toxicology, Medical School, Aristotle University Thessaloniki, Thessaloniki, 54124, Greece.

In several medico-legal cases, bone samples analysis may provide the only source of toxicological information. This case study reports the analysis of a human bone specimen, belonging to a 46-year-old man, found 3 months after his death due to cervical-thoracic injuries in a motorcycle accident. Bone specimen was the only available material for toxicological analysis, among few skull hair and rotten skin. Read More

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http://doi.wiley.com/10.1111/1556-4029.13890
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http://dx.doi.org/10.1111/1556-4029.13890DOI Listing
March 2019
23 Reads

Inadequate benzodiazepine dosing may result in progression to refractory and non-convulsive status epilepticus.

Epileptic Disord 2018 Aug;20(4):265-269

Department of Neurology, Wayne State University/Detroit Medical Center, Detroit, MI USA.

Status epilepticus (SE) is defined as ongoing seizures lasting longer than five minutes or multiple seizures without recovery. Benzodiazepines (BZDs) are first-line agents for the management of SE. Our objective was to evaluate BZD dosing in SE patients and its effects on clinical/electrographic outcomes. Read More

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http://dx.doi.org/10.1684/epd.2018.0987DOI Listing
August 2018
3 Reads

Rate of small-molecular drug transport across the blood-brain barrier in a pericyte-deficient state.

Eur J Pharm Sci 2018 Nov 9;124:182-187. Epub 2018 Aug 9.

Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden. Electronic address:

Close interactions between pericytes and brain endothelial cells are essential for keeping the blood-brain barrier (BBB) functional and to restrict the transport of various xenobiotics from blood circulation to the brain parenchyma. Profound understanding of pericyte roles at the BBB and underlying mechanisms for the regulation of BBB transport are important as a potential strategy to improve drug delivery in treatment of CNS disorders. The aim of the present study was to investigate pericyte role in the rate of small-molecular drug transport across the BBB, by examining three model compounds in a pericyte-deficient state. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09280987183037
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http://dx.doi.org/10.1016/j.ejps.2018.08.009DOI Listing
November 2018
20 Reads

[A Lot of Hot Steam: the Cannabinoid Hyperemesis Syndrome].

Dtsch Med Wochenschr 2018 Aug 7;143(16):1182-1185. Epub 2018 Aug 7.

Sana Klinikum Lichtenberg, Klinik für Innere Medizin I Schwerpunkt: Gastroenterologie.

History:  The 43-year-old patient was admitted because of vomiting and abdominal pain. He had a history of depression and multiple discus prolapses. He reported the consumption of three beers per day. Read More

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http://dx.doi.org/10.1055/a-0599-9317DOI Listing
August 2018
5 Reads

Etomidate Sedation for Advanced Endoscopic Procedures.

Dig Dis Sci 2019 01 27;64(1):144-151. Epub 2018 Jul 27.

Division of Gastroenterology, Department of Internal Medicine, Digestive Disease Center, Cheonan Hospital, Soonchunhyang University School of Medicine, 31, Sooncheonhyang 6-gil, Dongnam-gu, Cheonan-si, Chungcheongnam-do, 31151, Republic of Korea.

Background And Study Aim: Although propofol is widely used for sedation for endoscopic procedures, concerns remain regarding cardiopulmonary adverse events. Etomidate has little effect on the cardiovascular and respiratory systems, but patient satisfaction analysis is lacking. We compared the efficacy and safety of balanced propofol and etomidate sedation during advanced endoscopic procedures. Read More

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http://link.springer.com/10.1007/s10620-018-5220-3
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http://dx.doi.org/10.1007/s10620-018-5220-3DOI Listing
January 2019
34 Reads

The effectiveness of transport in a toy car for reducing preoperative anxiety in preschool children: a randomised controlled prospective trial.

Br J Anaesth 2018 Aug 4;121(2):438-444. Epub 2018 May 4.

Department of Anesthesia and Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. Electronic address:

Background: This study was designed to determine whether transport of a paediatric inpatient in a children's ride-on toy car has an effect on perioperative levels of anxiety compared with transport on a hospital gurney with or without oral midazolam premedication.

Methods: In this prospective study, 108 children aged 2-5 yr with congenital heart disease and undergoing first surgical correction were randomly allocated to one of three groups: Group C (transport in a children's ride-on car), Group G (transport on a gurney without premedication), or Group M (transport on a gurney and received premedication of oral midazolam 0.5 mg kg). Read More

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http://dx.doi.org/10.1016/j.bja.2018.02.067DOI Listing
August 2018
2 Reads

The treatment of trismus with Ativan: a 3-year-old with difficulty opening her mouth.

BMJ Case Rep 2018 Jul 15;2018. Epub 2018 Jul 15.

UNC Health Care System, Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1136/bcr-2018-225894DOI Listing
July 2018
18 Reads

Serotonin Syndrome in the Perioperative Setting.

Am J Case Rep 2018 Jul 16;19:833-835. Epub 2018 Jul 16.

Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, USA.

BACKGROUND Serotonin syndrome is a life-threatening condition that can lead to neurologic complications and is associated with the use of serotonergic medications. As the use of antidepressant medications has increased, the incidence of perioperative serotonin syndrome has transitioned from a rare diagnosis to one that should be considered as a differential diagnosis for any patient displaying signs of neuroexcitation. CASE REPORT A 70-year-old man (ASA 2) with a history of vestibular migraines (treated with venlafaxine), gastroesophageal reflux disease, and benign prostatic hyperplasia presented to our institution for photoselective vaporization of the prostate. Read More

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http://dx.doi.org/10.12659/AJCR.909497DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061453PMC
July 2018
20 Reads

Vaginal diazepam plus transcutaneous electrical nerve stimulation to treat vestibulodynia: A randomized controlled trial.

Eur J Obstet Gynecol Reprod Biol 2018 Sep 27;228:148-153. Epub 2018 Jun 27.

Lower Genital Tract Disease Unit, V. Buzzi Hospital-University of Milan, Milan, Italy.

Objective: To assess the effectiveness of vaginal diazepam in addition to transcutaneous electrical nerve stimulation (TENS) in the treatment of vestibulodynia (VBD).

Study Design: This study was a randomized, double-blind, placebo-controlled trial. Forty-two patients with VBD were randomized, 21 underwent diazepam and TENS (diazepam group) and 21 received placebo and TENS (placebo group). Read More

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http://dx.doi.org/10.1016/j.ejogrb.2018.06.026DOI Listing
September 2018
58 Reads

Diazepam reverses increased anxiety-like behavior, social behavior deficit, and dopamine dysregulation following withdrawal from acute amphetamine.

Neuropsychopharmacology 2018 11 18;43(12):2418-2425. Epub 2018 Jun 18.

Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA, 15217, USA.

Psychostimulants such as amphetamine (AMPH) increase dopamine (DA) release from ventral tegmental area (VTA) neurons, which is associated with their acute reinforcing actions. This positive state is followed by a negative affective state during the withdrawal period each time the drug is taken (i.e. Read More

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http://dx.doi.org/10.1038/s41386-018-0123-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180061PMC
November 2018
18 Reads

Pharmacological characterization of nicotine-induced tremor: Responses to anti-tremor and anti-epileptic agents.

J Pharmacol Sci 2018 Jun 7;137(2):162-169. Epub 2018 Jun 7.

Department of Pharmacology, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan. Electronic address:

We previously showed that nicotine evoked kinetic tremor by activating the inferior olive, which is implicated in the pathogenesis of essential tremor, via α7 nicotinic acetylcholine receptors. Here, we evaluated the effects of various anti-tremor and anti-epileptic agents on nicotine-induced tremor in mice to clarify the pharmacological characteristics of nicotine tremor. Drugs effective for essential tremor, propranolol, diazepam and phenobarbital, all significantly inhibited kinetic tremor induced by an intraperitoneal (i. Read More

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http://dx.doi.org/10.1016/j.jphs.2018.05.007DOI Listing
June 2018
3 Reads
2.360 Impact Factor

Combination of phenobarbital with phenytoin and pregabalin produces synergy in the mouse tonic-clonic seizure model: An isobolographic analysis.

Epilepsy Res 2018 09 18;145:116-122. Epub 2018 Jun 18.

Department of Medical Anthropology, Institute of Rural Health, Lublin, Poland.

Aims: Despite many antiepileptic drugs (AEDs) are available to treat epilepsy, there is still about 30% of epilepsy patients inadequately treated with these AEDs. For these patients, polytherapy with two or three AEDs to fully control their seizure attacks is recommended. Unfortunately, polytherapy is always associated with drug interactions, whose nature may be beneficial, neutral or unfavorable. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2018.06.003DOI Listing
September 2018
23 Reads

Experimental Substantiation of Inhalation Administration of Pathogenic Therapy of Toxic Convulsive Disorder for Correction of External Respiration Disorders.

Bull Exp Biol Med 2018 Jun 19;165(2):225-229. Epub 2018 Jun 19.

, City Hospital No. 40, St. Petersburg, Russia.

We studied the dynamics of respiratory function in rats during intratracheal poisoning with diisopropyl fluorophosphate and pentylenetetrazole in doses corresponding to the LD50 in humans. The maximum of external respiration impairment was recorded in 30 min after poisoning. Administration of diazepam and atropine both separately and in combination during the development of the first signs of poisoning did not significantly affect the respiration parameters, but reduced the incidence of seizures and contributed to a decrease in the rate of animal death. Read More

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http://dx.doi.org/10.1007/s10517-018-4135-5DOI Listing
June 2018
2 Reads

Long-term persistence of withdrawal of temazepam, zopiclone, and zolpidem in older adults: a 3-year follow-up study.

BMC Geriatr 2018 06 15;18(1):142. Epub 2018 Jun 15.

Division of Pharmacology and Pharmacotherapy, Clinical Pharmacy Group, University of Helsinki, Helsinki, Finland.

Background: Studies on persistence of benzodiazepine agonist (BZDA) withdrawal in older outpatients are few, and few studies on long-term persistence over years have yet been published. To describe the persistence of temazepam, zolpidem, and zopiclone (BZDA) withdrawal among older outpatients at 3 years from the beginning of withdrawal, as well as any changes in use of other medications.

Methods: 92 outpatients (≥55 years) with primary insomnia, long-term BZDA use as hypnotics (mean duration of BZDA use 9. Read More

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http://dx.doi.org/10.1186/s12877-018-0829-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003076PMC
June 2018
6 Reads

Review: Adjunctive pharmacologic approaches for benzodiazepine tapers.

Drug Alcohol Depend 2018 08 31;189:96-107. Epub 2018 May 31.

Division of Alcohol and Drug Abuse, McLean Hospital, Harvard Medical School, 115 Mill St, Belmont, MA 02478, USA.

Background: Many patients require discontinuation of benzodiazepines due to a reduction in drug efficacy over time, the development of a sedative use disorder, or unwanted side effects. Benzodiazepine discontinuation can pose a significant challenge for prescribing clinicians due to potential withdrawal symptoms and a recurrence of psychiatric complaints.

Methods: A PubMed literature search was conducted using the medical subject heading of benzodiazepines in combination with the following key words: discontinuation, withdrawal, detoxification, cessation, dependence, addiction, substance use disorders, or long term. Read More

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http://dx.doi.org/10.1016/j.drugalcdep.2018.04.028DOI Listing
August 2018
28 Reads

Diazepam suppresses the stress-induced dopaminergic release in the amygdala of methamphetamine-sensitized rat.

Eur J Pharmacol 2018 Aug 6;833:247-254. Epub 2018 Jun 6.

Department of Psychiatry, Tokyo Women's Medical University, Kawada-cho 8-1, Shinjuku-ku, Tokyo 162-8666, Japan. Electronic address:

Although the benzodiazepine class of drugs has proven useful in treating anxiety symptoms, recent studies yield no consistent empirical support for their use in treating psychiatric disorders. However, animal studies using a fear conditioning paradigm have suggested that benzodiazepines facilitate fear memory extinction, dependent on treatment timing and subject conditions. However, we have no data on the effect of subject conditions. Read More

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http://dx.doi.org/10.1016/j.ejphar.2018.05.048DOI Listing
August 2018
3 Reads

Novel psychoactive substances: overdose of 3-fluorophenmetrazine (3-FPM) and etizolam in a 33-year-old man.

BMJ Case Rep 2018 Jun 8;2018. Epub 2018 Jun 8.

Department of Medicine, Memorial University of Newfoundland, St. John's, Newfoundland and Labrador, Canada.

Though illegal in the UK, in many countries novel psychoactive substances are quasi-legal synthetic compounds that are widely available online under the guise of research chemicals. These substances are relatively cheap and are often undetectable in standard drug screens. Nearly 200 such compounds are introduced yearly, and little is usually known about their metabolism or physiological effects. Read More

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http://dx.doi.org/10.1136/bcr-2018-224995DOI Listing
June 2018
14 Reads

Leaves of Spondias mombin L. a traditional anxiolytic and antidepressant: Pharmacological evaluation on zebrafish (Danio rerio).

J Ethnopharmacol 2018 Oct 28;224:563-578. Epub 2018 May 28.

Programa de Pós-graduação em Ciências Farmacêuticas, Departamento de Ciências Biológicas e da Saúde, Universidade Federal do Amapá, Macapá, Amapá, Brazil; Laboratório de Pesquisa em Fármacos, Curso de Farmácia, Departamento de Ciências Biológicas e da Saúde, Universidade Federal do Amapá, Macapá, Amapá, Brazil; Rede Bionorte, Programa de Pós-graduação em Biotecnologia, Universidade Federal do Amapá, Brazil. Electronic address:

Ethnobotanical Relevance: Spondias mombin L. is a plant dispersed throughout the tropical regions of South America, Africa, and Asia, being found mainly in the North and Northeast of Brazil, where the leaves are used in preparations for neuropsychiatric disorders. Therefore, it is of great importance to carry out studies in different pharmacological models that can prove the traditional use of this plant species. Read More

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http://dx.doi.org/10.1016/j.jep.2018.05.037DOI Listing
October 2018
12 Reads
3.000 Impact Factor

The apoptotic effect of midazolam on the salivary gland of rats and the reversal effect by pilocarpine.

Can J Physiol Pharmacol 2018 Sep 30;96(9):898-901. Epub 2018 May 30.

a Graduate Program, Dentistry Course, Life Sciences School, Catholic University of Paraná, Curitiba, Brazil. Rua Imaculada Conceição, 1155, Prado Velho 80.215-901, Curitiba, PR, Brazil.

To evaluate the apoptosis in parotid glands of rats treated with midazolam associated or not with pilocarpine, 60 Wistar rats were assigned to 6 groups: control groups received saline solution for 30 days (S) and 60 days (S) and the other groups received pilocarpine for 60 days (P), midazolam for 30 days (M), midazolam for 30 days and 30 days of saline (M + S), and finally midazolam for 30 days and 30 days of midazolam and pilocarpine (M + MP). Histological sections were subjected to the TdT-mediated dUTP-biotin nick and labeling technique. The number of positive and negative cells was quantified, calculating the apoptotic index. Read More

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http://dx.doi.org/10.1139/cjpp-2018-0076DOI Listing
September 2018
3 Reads

No effect of sex and estrous cycle on the fear potentiated startle response in rats.

Behav Brain Res 2018 10 24;351:24-33. Epub 2018 May 24.

Division of Pharmacology, UIPS (Utrecht Institute of Pharmaceutical Sciences), Universiteitsweg 99, 3584 CG Utrecht, Netherlands.

The prevalence of anxiety disorders is higher in women than in men. Yet preclinical studies on anxiety are mostly performed in male subjects. This may have limited our understanding of mechanisms contributing to anxiety disorders. Read More

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http://dx.doi.org/10.1016/j.bbr.2018.05.022DOI Listing
October 2018
5 Reads

Benzodiazepine-refractory status epilepticus, neuroinflammation, and interneuron neurodegeneration after acute organophosphate intoxication.

Biochim Biophys Acta Mol Basis Dis 2018 09 23;1864(9 Pt B):2845-2858. Epub 2018 May 23.

Department of Neuroscience and Experimental Therapeutics, Texas A&M University Health Science Center, College of Medicine, Bryan, TX 77807, USA. Electronic address:

Nerve agents and some pesticides such as diisopropylfluorophosphate (DFP) cause neurotoxic manifestations that include seizures and status epilepticus (SE), which are potentially lethal and carry long-term neurological morbidity. Current antidotes for organophosphate (OP) intoxication include atropine, 2-PAM and diazepam (a benzodiazepine for treating seizures and SE). There is some evidence for partial or complete loss of diazepam anticonvulsant efficacy when given 30 min or later after exposure to an OP; this condition is known as refractory SE. Read More

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http://dx.doi.org/10.1016/j.bbadis.2018.05.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6066461PMC
September 2018
12 Reads

[Acupuncture at back- points of five , Geshu (BL 17) and Shenmen (HT 7) for the treatment of menopausal insomnia].

Authors:
Oujing Li Fan Wang

Zhongguo Zhen Jiu 2018 May;38(5):4693-72

Department of Acupuncture and Moxibustion, Beijing Tibetan Hospital of China Tibetology Research Center, Beijing 100029.

Objective: To compare the clinical efficacy differences between acupuncture at back- points of five , Geshu (BL 17), Shenmen (HT 7) and regular medication for the treatment of menopausal insomnia.

Methods: A total of 128 female patients of menopausal insomnia were randomly divided into an observation group and a control group, 64 cases in each one. Four patients in the observation group and 2 patients in the control group dropped out during the treatment. Read More

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http://dx.doi.org/10.13703/j.0255-2930.2018.05.005DOI Listing
May 2018
3 Reads

Anaesthesia for chest wall reconstruction in a patient with Poland syndrome: CARE-compliant case report and literature review.

BMC Anesthesiol 2018 05 24;18(1):57. Epub 2018 May 24.

Department of Anesthesiology and Pain medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Road, Wuhan, 430030, People's Republic of China.

Background: Poland syndrome is a rare congenital disease, characterized by agenesis/hypoplasia of the pectoralis major muscle, usually associated with variable thoracic anomalies that needed chest wall reconstruction under general anesthesia. Anaesthetic management in Poland syndrome has scarcely been described.

Case Presentation: Here, we present our anaesthetic management of Nuss procedure for chest wall correction in a 5 years old patient with Poland syndrome. Read More

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http://dx.doi.org/10.1186/s12871-018-0518-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968485PMC
May 2018
10 Reads

Bioisosteres of ethyl 8-ethynyl-6-(pyridin-2-yl)-4H-benzo[f]imidazo [1,5-a][1,4]diazepine-3-carboxylate (HZ-166) as novel alpha 2,3 selective potentiators of GABA receptors: Improved bioavailability enhances anticonvulsant efficacy.

Neuropharmacology 2018 07 3;137:332-343. Epub 2018 May 3.

The Lilly Research Labs, Eli Lilly and Company, Indianapolis, IN, USA. Electronic address:

HZ-166 has previously been characterized as an α2,3-selective GABA receptor modulator with anticonvulsant, anxiolytic, and anti-nociceptive properties but reduced motor effects. We discovered a series of ester bioisosteres with reduced metabolic liabilities, leading to improved efficacy as anxiolytic-like compounds in rats. In the present study, we evaluated the anticonvulsant effects KRM-II-81 across several rodent models. Read More

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http://dx.doi.org/10.1016/j.neuropharm.2018.05.006DOI Listing
July 2018
7 Reads

Injection Butorphanol dependence: A case report.

Asian J Psychiatr 2018 Jun 14;35:45-46. Epub 2018 May 14.

Department of Psychiatry & National Drug Dependence Treatment Center, All India Institute of Medical Sciences, New Delhi, India. Electronic address:

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http://dx.doi.org/10.1016/j.ajp.2018.05.008DOI Listing
June 2018
1 Read

Beneficial Outcome of Urethane Treatment Following Status Epilepticus in a Rat Organophosphorus Toxicity Model.

eNeuro 2018 Mar-Apr;5(2). Epub 2018 Apr 17.

Department of Pharmacology, Emory University, Atlanta, GA 30322.

The efficacy of benzodiazepines to terminate electrographic status epilepticus (SE) declines the longer a patient is in SE. Therefore, alternative methods for ensuring complete block of SE and refractory SE are necessary. We compared the ability of diazepam and a subanesthetic dose of urethane to terminate prolonged SE and mitigate subsequent pathologies. Read More

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http://eneuro.org/lookup/doi/10.1523/ENEURO.0070-18.2018
Publisher Site
http://dx.doi.org/10.1523/ENEURO.0070-18.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952304PMC
January 2019
7 Reads

Immunizations under sedation at a paediatric hospital in Melbourne, Australia from 2012-2016.

Vaccine 2018 06 9;36(25):3681-3685. Epub 2018 May 9.

Department of General Medicine, Royal Children's Hospital Melbourne, Melbourne, Australia; Gastro and Food Allergy Research Group and Melbourne Children's Trial Centre, Murdoch Children's Research Institute and Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia.

Background: Sedation for immunizations is of particular importance in a subset of paediatric patients with anxiety disorders, needle phobia, developmental or behavioural disorders. The Royal Children's Hospital (RCH) Melbourne offers a unique immunization under sedation service for these patients. We aimed to evaluate the number and types of patients using inpatient sedation for immunizations, distraction and sedation techniques used, and outcomes of these procedures. Read More

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http://dx.doi.org/10.1016/j.vaccine.2018.05.018DOI Listing
June 2018
4 Reads

Detection of stress and the effects of central nervous system depressants by gastrointestinal smooth muscle electromyography in wakeful rats.

Life Sci 2018 Jul 7;205:1-8. Epub 2018 May 7.

Department of Pharmacodynamics and Biopharmacy, Faculty of Pharmacy, University of Szeged, Eötvös utca 6, 6720 Szeged, Hungary. Electronic address:

Aims: The altered gut-brain interaction can be in the background of functional gastrointestinal (GI) disorders. In the GI tract, the slow-wave myoelectric signals can be detected by electromyography (EMG). The aims of our study were to follow up the stress induced alteration in the GI tract by smooth muscle EMG in wakeful rats. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00243205183025
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http://dx.doi.org/10.1016/j.lfs.2018.05.015DOI Listing
July 2018
6 Reads

Clarified Açaí () Juice as an Anticonvulsant Agent Mechanistic Study of GABAergic Targets.

Oxid Med Cell Longev 2018 20;2018:2678089. Epub 2018 Mar 20.

Laboratório de Farmacologia Molecular, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, PA, Brazil.

Seizures affect about 50 million people around the world. Approximately 30% of seizures are refractory to the current pharmacological arsenal, so, the pursuit of new therapeutic alternatives is essential. Clarified (EO) juice showed anticonvulsant properties similar to diazepam in an model with pentylenetetrazol, a GABA receptor blocker. Read More

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http://dx.doi.org/10.1155/2018/2678089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5883935PMC
October 2018
9 Reads

Paradoxical reaction to benzodiazepines in elderly - Case series.

Asian J Psychiatr 2018 Jun 25;35:8-10. Epub 2018 Apr 25.

Geriatric Clinic & Services, Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, 560029, India. Electronic address:

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http://dx.doi.org/10.1016/j.ajp.2018.04.037DOI Listing
June 2018
3 Reads