7,836 results match your criteria Sedative Hypnotic Anxiolytic Use Disorders


Application of sedation-agitation scale in conscious sedation before bronchoscopy in children.

Medicine (Baltimore) 2019 Jan;98(1):e14035

Department of Pediatric Pulmonology and Immunology, West China Second University Hospital of Sichuan University.

This retrospective study investigated the application of the sedation-agitation scale (SAS) in pediatric bronchoscopy by observing its effects on sedative dosages and adverse reactions.Children who underwent sedation before bronchoscopy, during the period from January 2014 to June 2017, were divided into control and SAS groups. Patients in the control group were administered a single dose of 0. Read More

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http://dx.doi.org/10.1097/MD.0000000000014035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344143PMC
January 2019
2 Reads

Generalized Convulsive Status Epilepticus Secondary to Jarisch-Herxheimer Reaction in Neurosyphilis: A Case Report and Literature Review.

Neurologist 2019 Jan;24(1):29-32

Department of Neurology, Health Sciences Center, Federal University of Santa Maria, Rio Grande do Sul, Brazil.

Introduction: Jarisch-Herxheimer reaction (JHR) is defined as a transient immunologic reaction, classically seen in patients during syphilis treatment. JHR is a rare cause of status epilepticus (SE) in neurosyphilis. We describe a case of generalized convulsive SE (GCSE) probably secondary to JHR in a patient with neurosyphilis. Read More

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http://dx.doi.org/10.1097/NRL.0000000000000219DOI Listing
January 2019
2 Reads

Determination of emerging chlorinated byproducts of diazepam in drinking water.

Chemosphere 2019 Mar 15;218:223-231. Epub 2018 Nov 15.

Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China; Beijing Key Laboratory of Diagnostic and Traceability Technologies for Food Poisoning, Beijing Center for Disease Prevention and Control, Beijing, 100013, China. Electronic address:

Diazepam (DZP) is often found in source water and drinking water at dozens of nanograms per liter levels. The transformation of DZP in water chlorination disinfection process has aroused new concern because the toxic disinfection byproducts (DBPs) might be produced. However, the DBPs of DZP have not been fully identified, and their occurrence levels in drinking water have not been reported. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2018.11.076DOI Listing
March 2019
1 Read

Gamma aminobutyric acid (GABA) receptor agonists for acute stroke.

Cochrane Database Syst Rev 2018 10 30;10:CD009622. Epub 2018 Oct 30.

Department of Neurology, Xuanwu Hospital, Capital Medical University, Changchun Street 45, Beijing, China, 100053.

Background: Gamma aminobutyric acid (GABA) receptor agonists have been shown to have a neuroprotectant effect in reducing infarct size and improving functional outcome in animal models of cerebrovascular disease. However, the sedative effects of GABA receptor agonists have limited their wider application in people with acute stroke, due to the potential risk of stupor. This is an update of a Cochrane Review first published in 2013, and previously updated in 2014 and 2016. Read More

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http://doi.wiley.com/10.1002/14651858.CD009622.pub5
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http://dx.doi.org/10.1002/14651858.CD009622.pub5DOI Listing
October 2018
4 Reads

A Retrospective Study of Dosing Weight and Outcomes for One Pediatric Dental Sedation Regimen.

Pediatr Dent 2018 Sep;40(5):346-351

Assistant professor, Department of Research and Graduate Programs, School of Dentistry, University of Missouri, Kansas City, Mo., USA.

The purpose of this study was to assess the use of a dosing scalar for association with the success of procedural sedation in pediatric dentistry. This cross-sectional, retrospective study assessed healthy two- to 12-year-olds who received an elixir of midazolam (0.3 mg/kg), meperidine (1. Read More

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September 2018
4 Reads

Prevalence of burnout, depression and job satisfaction among French senior and resident radiation oncologists.

Cancer Radiother 2018 Dec 19;22(8):784-789. Epub 2018 Oct 19.

Département de radiothérapie, centre Henri-Becquerel, 1, rue d'Amiens, 76000 Rouen, France; CNRS, Laboratoire QuantIF, EA4108-Litis, FR UMR 3638, 1, rue d'Amiens, 76000 Rouen, France; Société française des jeunes radiothérapeutes oncologues (SFjRO), centre Antoine-Béclère, 47, rue de la Colonie, 75013 Paris, France.

Purpose: Cancer caregivers are at high risk of burn-out, with potential severe consequences on professionals' health and on patients' care. We have investigated the prevalence of burn-out and its impact in terms of psychological morbidity among French radiation oncologists.

Methods And Materials: An anonymous online questionnaire was advertised in all French senior radiation oncologists and residents, including demographical data, job-related stress factors, drug use, the Maslach Burn-out Inventory (MBI) and the General Health Questionnaire (GHQ-12). Read More

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http://dx.doi.org/10.1016/j.canrad.2018.02.005DOI Listing
December 2018
2 Reads

Essential Oil and Linalool Counteract Social Aversion Induced by Social Defeat.

Molecules 2018 Oct 19;23(10). Epub 2018 Oct 19.

Departament of Psicobiology, University of Valencia, Avda. Blasco Ibáñez, 21, 46010 Valencia, Spain.

Many vegetable extracts, essential oils, and their main constituents are active on the Central Nervous System (CNS). In fact, they have been used as sedatives, hypnotics, or tranquilizers for their activity in treating CNS disorders. In this research, we studied the possible activities of (LA) essential oil and of its main constituent, linalool, as anti-stress compounds on anxiety and social interaction and their in vitro effects on proteins (pERK and PKA) involved in the transmission of the signal. Read More

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http://www.mdpi.com/1420-3049/23/10/2694
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http://dx.doi.org/10.3390/molecules23102694DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222471PMC
October 2018
14 Reads

The leaves of Crataeva nurvala Buch-Ham. modulate locomotor and anxiety behaviors possibly through GABAergic system.

BMC Complement Altern Med 2018 Oct 19;18(1):283. Epub 2018 Oct 19.

Designated Reference Institute for Chemical Measurement (DRiCM), Bangladesh Council of Scientific & Industrial Research, Dhaka, 1205, Bangladesh.

Background: Crataeva nurvala Buch-Hum is an indigenous herb, extensively used in traditional medicines of the South Asian countries to treat inflammation, rheumatic fever, gastric irritation, and constipation. Despite this wide range of uses, very little information is known regarding its effects on the central nervous system (CNS). Therefore, this study evaluated the neuropharmacological properties of methanolic extract of Crataeva nurvala leaves (MECN) using a number of behavioral models in animals. Read More

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https://bmccomplementalternmed.biomedcentral.com/articles/10
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http://dx.doi.org/10.1186/s12906-018-2338-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6194725PMC
October 2018
5 Reads
2.020 Impact Factor

A clinical study to evaluate the cardiopulmonary characteristics of two different anaesthetic protocols for immobilization of healthy chimpanzees (Pan troglodytes).

Vet Anaesth Analg 2018 Nov 23;45(6):794-801. Epub 2018 Aug 23.

School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington, UK. Electronic address:

Objective: To characterize the cardiopulmonary characteristics of two different anaesthetic protocols (tiletamine/zolazepam ± medetomidine) and their suitability for the immobilization of healthy chimpanzees undergoing cardiac assessment.

Study Design: Prospective, clinical, longitudinal study.

Animals: Six chimpanzees (Pan troglodytes) aged 4-16 years weighing 19. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S14672987183018
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http://dx.doi.org/10.1016/j.vaa.2018.06.015DOI Listing
November 2018
17 Reads

Aqueous Extract of Semen Exerts Anxiolytic Effects during Nicotine Withdrawal via Improvement of Amygdaloid CRF/CRF1R Signaling.

Evid Based Complement Alternat Med 2018 2;2018:2419183. Epub 2018 Sep 2.

Medical Research Center, College of Oriental Medicine, Daegu Haany University, Gyeongsan-si 38610, Republic of Korea.

Anxiety during nicotine withdrawal (NicW) is a key risk factor for smoking relapse. Semen (SZS), which is a prototypical hypnotic-sedative herb in Oriental medicine, has been clinically used to treat insomnia and general anxiety disorders for thousands of years. Thus, the present study evaluated the effects of the aqueous extract of SZS (AESZS) on NicW-induced anxiety in male rats that received subcutaneous administrations of nicotine (Nic) (0. Read More

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http://dx.doi.org/10.1155/2018/2419183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6139233PMC
September 2018
2 Reads

Pharmacological Evaluation of L. and L., Medicinal Plants Used to Treat Anxiety and Insomnia in Colombian Caribbean Coast.

Evid Based Complement Alternat Med 2018 7;2018:5921514. Epub 2018 Aug 7.

Biological Evaluation of Promising Substances Group, Faculty of Pharmaceutical Sciences, University of Cartagena, Cartagena 130015, Colombia.

Anxiety disorders are highly prevalent, chronic, and disabling conditions that impose enormous health and economic costs both on individuals and on society. Medicinal plants are an invaluable source of bioactive metabolites that can be useful as new pharmacological treatment. Teas from and are employed by Colombian populations to treat stress and insomnia. Read More

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http://dx.doi.org/10.1155/2018/5921514DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6106973PMC
August 2018
16 Reads

Inadequate benzodiazepine dosing may result in progression to refractory and non-convulsive status epilepticus.

Epileptic Disord 2018 Aug;20(4):265-269

Department of Neurology, Wayne State University/Detroit Medical Center, Detroit, MI USA.

Status epilepticus (SE) is defined as ongoing seizures lasting longer than five minutes or multiple seizures without recovery. Benzodiazepines (BZDs) are first-line agents for the management of SE. Our objective was to evaluate BZD dosing in SE patients and its effects on clinical/electrographic outcomes. Read More

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http://dx.doi.org/10.1684/epd.2018.0987DOI Listing
August 2018
3 Reads

Rate of small-molecular drug transport across the blood-brain barrier in a pericyte-deficient state.

Eur J Pharm Sci 2018 Nov 9;124:182-187. Epub 2018 Aug 9.

Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden. Electronic address:

Close interactions between pericytes and brain endothelial cells are essential for keeping the blood-brain barrier (BBB) functional and to restrict the transport of various xenobiotics from blood circulation to the brain parenchyma. Profound understanding of pericyte roles at the BBB and underlying mechanisms for the regulation of BBB transport are important as a potential strategy to improve drug delivery in treatment of CNS disorders. The aim of the present study was to investigate pericyte role in the rate of small-molecular drug transport across the BBB, by examining three model compounds in a pericyte-deficient state. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09280987183037
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http://dx.doi.org/10.1016/j.ejps.2018.08.009DOI Listing
November 2018
13 Reads

[A Lot of Hot Steam: the Cannabinoid Hyperemesis Syndrome].

Dtsch Med Wochenschr 2018 Aug 7;143(16):1182-1185. Epub 2018 Aug 7.

Sana Klinikum Lichtenberg, Klinik für Innere Medizin I Schwerpunkt: Gastroenterologie.

History:  The 43-year-old patient was admitted because of vomiting and abdominal pain. He had a history of depression and multiple discus prolapses. He reported the consumption of three beers per day. Read More

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http://dx.doi.org/10.1055/a-0599-9317DOI Listing
August 2018
4 Reads

Etomidate Sedation for Advanced Endoscopic Procedures.

Dig Dis Sci 2019 01 27;64(1):144-151. Epub 2018 Jul 27.

Division of Gastroenterology, Department of Internal Medicine, Digestive Disease Center, Cheonan Hospital, Soonchunhyang University School of Medicine, 31, Sooncheonhyang 6-gil, Dongnam-gu, Cheonan-si, Chungcheongnam-do, 31151, Republic of Korea.

Background And Study Aim: Although propofol is widely used for sedation for endoscopic procedures, concerns remain regarding cardiopulmonary adverse events. Etomidate has little effect on the cardiovascular and respiratory systems, but patient satisfaction analysis is lacking. We compared the efficacy and safety of balanced propofol and etomidate sedation during advanced endoscopic procedures. Read More

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http://link.springer.com/10.1007/s10620-018-5220-3
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http://dx.doi.org/10.1007/s10620-018-5220-3DOI Listing
January 2019
26 Reads

The effectiveness of transport in a toy car for reducing preoperative anxiety in preschool children: a randomised controlled prospective trial.

Br J Anaesth 2018 Aug 4;121(2):438-444. Epub 2018 May 4.

Department of Anesthesia and Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. Electronic address:

Background: This study was designed to determine whether transport of a paediatric inpatient in a children's ride-on toy car has an effect on perioperative levels of anxiety compared with transport on a hospital gurney with or without oral midazolam premedication.

Methods: In this prospective study, 108 children aged 2-5 yr with congenital heart disease and undergoing first surgical correction were randomly allocated to one of three groups: Group C (transport in a children's ride-on car), Group G (transport on a gurney without premedication), or Group M (transport on a gurney and received premedication of oral midazolam 0.5 mg kg). Read More

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http://dx.doi.org/10.1016/j.bja.2018.02.067DOI Listing
August 2018
1 Read

Serotonin Syndrome in the Perioperative Setting.

Am J Case Rep 2018 Jul 16;19:833-835. Epub 2018 Jul 16.

Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, USA.

BACKGROUND Serotonin syndrome is a life-threatening condition that can lead to neurologic complications and is associated with the use of serotonergic medications. As the use of antidepressant medications has increased, the incidence of perioperative serotonin syndrome has transitioned from a rare diagnosis to one that should be considered as a differential diagnosis for any patient displaying signs of neuroexcitation. CASE REPORT A 70-year-old man (ASA 2) with a history of vestibular migraines (treated with venlafaxine), gastroesophageal reflux disease, and benign prostatic hyperplasia presented to our institution for photoselective vaporization of the prostate. Read More

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http://dx.doi.org/10.12659/AJCR.909497DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061453PMC
July 2018
14 Reads

Vaginal diazepam plus transcutaneous electrical nerve stimulation to treat vestibulodynia: A randomized controlled trial.

Eur J Obstet Gynecol Reprod Biol 2018 Sep 27;228:148-153. Epub 2018 Jun 27.

Lower Genital Tract Disease Unit, V. Buzzi Hospital-University of Milan, Milan, Italy.

Objective: To assess the effectiveness of vaginal diazepam in addition to transcutaneous electrical nerve stimulation (TENS) in the treatment of vestibulodynia (VBD).

Study Design: This study was a randomized, double-blind, placebo-controlled trial. Forty-two patients with VBD were randomized, 21 underwent diazepam and TENS (diazepam group) and 21 received placebo and TENS (placebo group). Read More

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http://dx.doi.org/10.1016/j.ejogrb.2018.06.026DOI Listing
September 2018
42 Reads

Pharmacological characterization of nicotine-induced tremor: Responses to anti-tremor and anti-epileptic agents.

J Pharmacol Sci 2018 Jun 7;137(2):162-169. Epub 2018 Jun 7.

Department of Pharmacology, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan. Electronic address:

We previously showed that nicotine evoked kinetic tremor by activating the inferior olive, which is implicated in the pathogenesis of essential tremor, via α7 nicotinic acetylcholine receptors. Here, we evaluated the effects of various anti-tremor and anti-epileptic agents on nicotine-induced tremor in mice to clarify the pharmacological characteristics of nicotine tremor. Drugs effective for essential tremor, propranolol, diazepam and phenobarbital, all significantly inhibited kinetic tremor induced by an intraperitoneal (i. Read More

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http://dx.doi.org/10.1016/j.jphs.2018.05.007DOI Listing
June 2018
2 Reads
2.360 Impact Factor

Experimental Substantiation of Inhalation Administration of Pathogenic Therapy of Toxic Convulsive Disorder for Correction of External Respiration Disorders.

Bull Exp Biol Med 2018 Jun 19;165(2):225-229. Epub 2018 Jun 19.

, City Hospital No. 40, St. Petersburg, Russia.

We studied the dynamics of respiratory function in rats during intratracheal poisoning with diisopropyl fluorophosphate and pentylenetetrazole in doses corresponding to the LD50 in humans. The maximum of external respiration impairment was recorded in 30 min after poisoning. Administration of diazepam and atropine both separately and in combination during the development of the first signs of poisoning did not significantly affect the respiration parameters, but reduced the incidence of seizures and contributed to a decrease in the rate of animal death. Read More

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http://dx.doi.org/10.1007/s10517-018-4135-5DOI Listing
June 2018
1 Read

Review: Adjunctive pharmacologic approaches for benzodiazepine tapers.

Drug Alcohol Depend 2018 08 31;189:96-107. Epub 2018 May 31.

Division of Alcohol and Drug Abuse, McLean Hospital, Harvard Medical School, 115 Mill St, Belmont, MA 02478, USA.

Background: Many patients require discontinuation of benzodiazepines due to a reduction in drug efficacy over time, the development of a sedative use disorder, or unwanted side effects. Benzodiazepine discontinuation can pose a significant challenge for prescribing clinicians due to potential withdrawal symptoms and a recurrence of psychiatric complaints.

Methods: A PubMed literature search was conducted using the medical subject heading of benzodiazepines in combination with the following key words: discontinuation, withdrawal, detoxification, cessation, dependence, addiction, substance use disorders, or long term. Read More

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http://dx.doi.org/10.1016/j.drugalcdep.2018.04.028DOI Listing
August 2018
22 Reads

Diazepam suppresses the stress-induced dopaminergic release in the amygdala of methamphetamine-sensitized rat.

Eur J Pharmacol 2018 Aug 6;833:247-254. Epub 2018 Jun 6.

Department of Psychiatry, Tokyo Women's Medical University, Kawada-cho 8-1, Shinjuku-ku, Tokyo 162-8666, Japan. Electronic address:

Although the benzodiazepine class of drugs has proven useful in treating anxiety symptoms, recent studies yield no consistent empirical support for their use in treating psychiatric disorders. However, animal studies using a fear conditioning paradigm have suggested that benzodiazepines facilitate fear memory extinction, dependent on treatment timing and subject conditions. However, we have no data on the effect of subject conditions. Read More

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http://dx.doi.org/10.1016/j.ejphar.2018.05.048DOI Listing
August 2018
3 Reads

Novel psychoactive substances: overdose of 3-fluorophenmetrazine (3-FPM) and etizolam in a 33-year-old man.

BMJ Case Rep 2018 Jun 8;2018. Epub 2018 Jun 8.

Department of Medicine, Memorial University of Newfoundland, St. John's, Newfoundland and Labrador, Canada.

Though illegal in the UK, in many countries novel psychoactive substances are quasi-legal synthetic compounds that are widely available online under the guise of research chemicals. These substances are relatively cheap and are often undetectable in standard drug screens. Nearly 200 such compounds are introduced yearly, and little is usually known about their metabolism or physiological effects. Read More

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http://dx.doi.org/10.1136/bcr-2018-224995DOI Listing
June 2018
11 Reads

Leaves of Spondias mombin L. a traditional anxiolytic and antidepressant: Pharmacological evaluation on zebrafish (Danio rerio).

J Ethnopharmacol 2018 Oct 28;224:563-578. Epub 2018 May 28.

Programa de Pós-graduação em Ciências Farmacêuticas, Departamento de Ciências Biológicas e da Saúde, Universidade Federal do Amapá, Macapá, Amapá, Brazil; Laboratório de Pesquisa em Fármacos, Curso de Farmácia, Departamento de Ciências Biológicas e da Saúde, Universidade Federal do Amapá, Macapá, Amapá, Brazil; Rede Bionorte, Programa de Pós-graduação em Biotecnologia, Universidade Federal do Amapá, Brazil. Electronic address:

Ethnobotanical Relevance: Spondias mombin L. is a plant dispersed throughout the tropical regions of South America, Africa, and Asia, being found mainly in the North and Northeast of Brazil, where the leaves are used in preparations for neuropsychiatric disorders. Therefore, it is of great importance to carry out studies in different pharmacological models that can prove the traditional use of this plant species. Read More

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http://dx.doi.org/10.1016/j.jep.2018.05.037DOI Listing
October 2018
4 Reads
3.000 Impact Factor

The apoptotic effect of midazolam on the salivary gland of rats and the reversal effect by pilocarpine.

Can J Physiol Pharmacol 2018 Sep 30;96(9):898-901. Epub 2018 May 30.

a Graduate Program, Dentistry Course, Life Sciences School, Catholic University of Paraná, Curitiba, Brazil. Rua Imaculada Conceição, 1155, Prado Velho 80.215-901, Curitiba, PR, Brazil.

To evaluate the apoptosis in parotid glands of rats treated with midazolam associated or not with pilocarpine, 60 Wistar rats were assigned to 6 groups: control groups received saline solution for 30 days (S) and 60 days (S) and the other groups received pilocarpine for 60 days (P), midazolam for 30 days (M), midazolam for 30 days and 30 days of saline (M + S), and finally midazolam for 30 days and 30 days of midazolam and pilocarpine (M + MP). Histological sections were subjected to the TdT-mediated dUTP-biotin nick and labeling technique. The number of positive and negative cells was quantified, calculating the apoptotic index. Read More

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http://dx.doi.org/10.1139/cjpp-2018-0076DOI Listing
September 2018
3 Reads

No effect of sex and estrous cycle on the fear potentiated startle response in rats.

Behav Brain Res 2018 10 24;351:24-33. Epub 2018 May 24.

Division of Pharmacology, UIPS (Utrecht Institute of Pharmaceutical Sciences), Universiteitsweg 99, 3584 CG Utrecht, Netherlands.

The prevalence of anxiety disorders is higher in women than in men. Yet preclinical studies on anxiety are mostly performed in male subjects. This may have limited our understanding of mechanisms contributing to anxiety disorders. Read More

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http://dx.doi.org/10.1016/j.bbr.2018.05.022DOI Listing
October 2018
2 Reads

Benzodiazepine-refractory status epilepticus, neuroinflammation, and interneuron neurodegeneration after acute organophosphate intoxication.

Biochim Biophys Acta Mol Basis Dis 2018 09 23;1864(9 Pt B):2845-2858. Epub 2018 May 23.

Department of Neuroscience and Experimental Therapeutics, Texas A&M University Health Science Center, College of Medicine, Bryan, TX 77807, USA. Electronic address:

Nerve agents and some pesticides such as diisopropylfluorophosphate (DFP) cause neurotoxic manifestations that include seizures and status epilepticus (SE), which are potentially lethal and carry long-term neurological morbidity. Current antidotes for organophosphate (OP) intoxication include atropine, 2-PAM and diazepam (a benzodiazepine for treating seizures and SE). There is some evidence for partial or complete loss of diazepam anticonvulsant efficacy when given 30 min or later after exposure to an OP; this condition is known as refractory SE. Read More

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http://dx.doi.org/10.1016/j.bbadis.2018.05.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6066461PMC
September 2018
5 Reads

[Acupuncture at back- points of five , Geshu (BL 17) and Shenmen (HT 7) for the treatment of menopausal insomnia].

Authors:
Oujing Li Fan Wang

Zhongguo Zhen Jiu 2018 May;38(5):4693-72

Department of Acupuncture and Moxibustion, Beijing Tibetan Hospital of China Tibetology Research Center, Beijing 100029.

Objective: To compare the clinical efficacy differences between acupuncture at back- points of five , Geshu (BL 17), Shenmen (HT 7) and regular medication for the treatment of menopausal insomnia.

Methods: A total of 128 female patients of menopausal insomnia were randomly divided into an observation group and a control group, 64 cases in each one. Four patients in the observation group and 2 patients in the control group dropped out during the treatment. Read More

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http://dx.doi.org/10.13703/j.0255-2930.2018.05.005DOI Listing
May 2018
2 Reads

Beneficial Outcome of Urethane Treatment Following Status Epilepticus in a Rat Organophosphorus Toxicity Model.

eNeuro 2018 Mar-Apr;5(2). Epub 2018 Apr 17.

Department of Pharmacology, Emory University, Atlanta, GA 30322.

The efficacy of benzodiazepines to terminate electrographic status epilepticus (SE) declines the longer a patient is in SE. Therefore, alternative methods for ensuring complete block of SE and refractory SE are necessary. We compared the ability of diazepam and a subanesthetic dose of urethane to terminate prolonged SE and mitigate subsequent pathologies. Read More

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http://eneuro.org/lookup/doi/10.1523/ENEURO.0070-18.2018
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http://dx.doi.org/10.1523/ENEURO.0070-18.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952304PMC
January 2019
6 Reads

Immunizations under sedation at a paediatric hospital in Melbourne, Australia from 2012-2016.

Vaccine 2018 06 9;36(25):3681-3685. Epub 2018 May 9.

Department of General Medicine, Royal Children's Hospital Melbourne, Melbourne, Australia; Gastro and Food Allergy Research Group and Melbourne Children's Trial Centre, Murdoch Children's Research Institute and Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia.

Background: Sedation for immunizations is of particular importance in a subset of paediatric patients with anxiety disorders, needle phobia, developmental or behavioural disorders. The Royal Children's Hospital (RCH) Melbourne offers a unique immunization under sedation service for these patients. We aimed to evaluate the number and types of patients using inpatient sedation for immunizations, distraction and sedation techniques used, and outcomes of these procedures. Read More

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http://dx.doi.org/10.1016/j.vaccine.2018.05.018DOI Listing
June 2018
3 Reads

Detection of stress and the effects of central nervous system depressants by gastrointestinal smooth muscle electromyography in wakeful rats.

Life Sci 2018 Jul 7;205:1-8. Epub 2018 May 7.

Department of Pharmacodynamics and Biopharmacy, Faculty of Pharmacy, University of Szeged, Eötvös utca 6, 6720 Szeged, Hungary. Electronic address:

Aims: The altered gut-brain interaction can be in the background of functional gastrointestinal (GI) disorders. In the GI tract, the slow-wave myoelectric signals can be detected by electromyography (EMG). The aims of our study were to follow up the stress induced alteration in the GI tract by smooth muscle EMG in wakeful rats. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00243205183025
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http://dx.doi.org/10.1016/j.lfs.2018.05.015DOI Listing
July 2018
5 Reads

Clarified Açaí () Juice as an Anticonvulsant Agent Mechanistic Study of GABAergic Targets.

Oxid Med Cell Longev 2018 20;2018:2678089. Epub 2018 Mar 20.

Laboratório de Farmacologia Molecular, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, PA, Brazil.

Seizures affect about 50 million people around the world. Approximately 30% of seizures are refractory to the current pharmacological arsenal, so, the pursuit of new therapeutic alternatives is essential. Clarified (EO) juice showed anticonvulsant properties similar to diazepam in an model with pentylenetetrazol, a GABA receptor blocker. Read More

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http://dx.doi.org/10.1155/2018/2678089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5883935PMC
October 2018
8 Reads

Rocuronium for control of muscle spasms in a tetanus patient with chronic methamphetamine use disorder.

BMJ Case Rep 2018 Apr 10;2018. Epub 2018 Apr 10.

Department of Neurosciences, University of the Philippines-Philippine General Hospital, Manila, Philippines.

This is a case of a 31-year-old Filipino man with chronic methamphetamine use disorder who developed tetanus from a necrotic skin graft over his left calcaneus, which was fractured after a motor vehicular accident. During the course of his illness, the patient's muscle spasms were unusually refractory to benzodiazepine, which is the first-line drug used in the management of muscle spasms. The muscle spasms were successfully controlled on the seventh day of illness with rocuronium at a dose of 10 μg/kg/min and midazolam at 0. Read More

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http://dx.doi.org/10.1136/bcr-2018-224391DOI Listing
April 2018
17 Reads

Neuropharmacological effects of essential oil from the leaves of Croton conduplicatus Kunth and possible mechanisms of action involved.

J Ethnopharmacol 2018 Jul 5;221:65-76. Epub 2018 Apr 5.

Núcleo de Estudos e Pesquisas de Plantas Medicinais (NEPLAME), Universidade Federal do Vale do São Francisco (UNIVASF), Petrolina, Pernambuco, Brazil. Electronic address:

Ethnopharmacological Relevance: Croton conduplicatus Kunth (Euphorbiaceae) is a Brazilian aromatic medicinal plant, widely known as "quebra-faca". In folk medicine, its leaves and stem-barks are used as a natural analgesic for the treatment of headaches.

Aim Of The Study: In this study, we describe for the first time the neuropharmacological potential of the essential oil obtained from the leaves of Croton conduplicatus (EO) in experimental models of pain, anxiety and insomnia. Read More

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http://dx.doi.org/10.1016/j.jep.2018.04.009DOI Listing
July 2018
7 Reads

Association between Delirium and Prehospitalization Medication in Poststroke Patients.

J Stroke Cerebrovasc Dis 2018 Jul 27;27(7):1914-1920. Epub 2018 Mar 27.

Department of Neurology, Japanese Red Cross Musashino Hospital, Musashino, Tokyo, Japan.

Purpose: Medication is an important risk factor for delirium; however, the association between delirium and prehospitalization medication is unclear. We investigated the association between prestroke medication and poststroke delirium.

Materials And Methods: All patients hospitalized in the stroke care unit from September 2011 to September 2012 were selected, and their delirium symptoms, patient information, and pre- and poststroke medications were analyzed. Read More

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2018.02.038DOI Listing
July 2018
3 Reads

Purchases of prescription drugs before an alcohol-related death: A ten-year follow-up study using linked routine data.

Drug Alcohol Depend 2018 05 23;186:175-181. Epub 2018 Mar 23.

Alcohol, Drugs and Addictions Unit, National Institute for Health and Welfare, Helsinki, Finland.

Background: Physician's intention to prescribe drugs could potentially be used to improve targeting of alcohol interventions and enhanced disease management to patients with a high risk of severe alcohol-related harm within outpatient settings.

Methods: Comparison of ten-year incidence trajectories of 13.8 million reimbursed purchases of prescription drugs among 303,057 Finnish men and women of whom 7490 ultimately died due to alcohol-related causes (Alc+), 14,954 died without alcohol involvement (Alc-), and 280,613 survived until the end of 2007. Read More

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http://dx.doi.org/10.1016/j.drugalcdep.2018.02.008DOI Listing
May 2018
6 Reads

Pre-hospital ambulance care of patients following a suspected seizure: A cross sectional study.

Seizure 2018 Apr 8;57:38-44. Epub 2018 Mar 8.

University of Lincoln, Community and Health Research Unit, School of Health and Social Care, Brayford Campus, Lincoln, Lincolnshire, LN6 7TS, UK.

Purpose: We aimed to investigate the characteristics of patients presenting to the ambulance service with suspected seizures, the costs of managing these patients and the factors which predicted transport to hospital.

Methods: We employed a cross-sectional design using routine clinical data from a UK regional ambulance service. Logistic regression was used to identify predictors of transport to hospital from ambulance response times, demographics, clinical (physiological) findings and treatments. Read More

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http://dx.doi.org/10.1016/j.seizure.2018.03.006DOI Listing
April 2018
3 Reads

Pharmacological characterization of the cannabinoid receptor 2 agonist, β-caryophyllene on seizure models in mice.

Seizure 2018 Apr 12;57:22-26. Epub 2018 Mar 12.

Institute of Biophysics and Biomedical Engineering, BAS, Sofia, Bulgaria.

Purpose: Activation of CB1 receptors, produces anticonvulsant effect accompanied by memory disturbance both in animal seizure tests and in patients with epilepsy. Few reports considered the role of CB2 receptor on seizure susceptibility and cognitive functions. The aim of the present study was to explore the effect of a selective CB2 receptor agonist β-caryophyllene (BCP) in models of seizures and cognition in mice. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10591311173061
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http://dx.doi.org/10.1016/j.seizure.2018.03.009DOI Listing
April 2018
17 Reads

Effect of Sedation Regimen on Weaning from Mechanical Ventilation in the Intensive Care Unit.

Clin Drug Investig 2018 Jun;38(6):535-543

Department of Anaesthesiology and Intensive Care, Danderyd Hospital, 18288, Stockholm, Sweden.

Background: Intensive care unit patients undergoing mechanical ventilation have traditionally been sedated to make them comfortable and to avoid pain and anxiety. However, this may lead to prolonged mechanical ventilation and a longer length of stay.

Objective: The aim of this retrospective study was to explore whether different sedation regimens influence the course and duration of the weaning process. Read More

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http://dx.doi.org/10.1007/s40261-018-0636-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5951865PMC
June 2018
6 Reads

Etizolam attenuates the reduction in cutaneous temperature induced in mice by exposure to synthetic predator odor.

Eur J Pharmacol 2018 Apr 10;824:157-162. Epub 2018 Feb 10.

Department of Sensory Physiology, Asahikawa Medical University, Asahikawa, Japan. Electronic address:

Anxiety- and stress-related disorders can be debilitating psychiatric conditions in humans. To prevent or ameliorate these conditions, reliable animal models are needed to evaluate the effects of anxiolytic drugs. Previously, we found that a mixture of three pyrazine analogues (P-mix) that were present at high levels in wolf urine induced fear-related responses in mice, rats and deer. Read More

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http://dx.doi.org/10.1016/j.ejphar.2018.02.015DOI Listing
April 2018
11 Reads
2.530 Impact Factor

Comparison of the effect of intravenous anesthetics used for anesthesia during electroconvulsive therapy on the hemodynamic safety and the course of ECT.

Psychiatr Pol 2017 Dec 30;51(6):1039-1058. Epub 2017 Dec 30.

II Klinika Psychiatryczna, Instytut Psychiatrii i Neurologii w Warszawie.

Electroconvulsive therapy (ECT) is the treatment method widely used in psychiatric disorders such as depression, bipolar disorder, schizophrenia and schizoaffective disorder. The advantage of ECT is therapeutic response that occurs significantly earlier than during pharmacotherapy. Initially ECTwas used without anesthesia. Read More

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http://dx.doi.org/10.12740/PP/75635DOI Listing
December 2017
4 Reads

Inhibition of the G9a/GLP histone methyltransferase complex modulates anxiety-related behavior in mice.

Acta Pharmacol Sin 2018 May 8;39(5):866-874. Epub 2018 Feb 8.

Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada.

Epigenetic gene-regulation abnormalities have been implicated in various neuropsychiatric disorders including schizophrenia and depression, as well as in the regulation of mood and anxiety. In addition, epigenetic mechanisms are involved in the actions of psychiatric drugs. Current anxiolytic drugs have significant shortcomings, and development of new medications is warranted. Read More

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http://www.nature.com/doifinder/10.1038/aps.2017.190
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http://dx.doi.org/10.1038/aps.2017.190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943902PMC
May 2018
13 Reads
2 Citations
2.500 Impact Factor

Oversedation of a Patient With Obstructive Sleep Apnea Prior to Imaging.

JAMA 2018 Feb;319(5):495-496

Northwestern Memorial Hospital, Chicago, Illinois.

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http://dx.doi.org/10.1001/jama.2017.22004DOI Listing
February 2018
3 Reads

Tranquilizer misuse among active cocaine users: Predictors of initiation.

Drug Alcohol Rev 2018 05 6;37(4):520-526. Epub 2018 Feb 6.

Department of Family Medicine, University of Montreal, Montreal, Canada.

Introduction And Aims: Tranquilizer use is associated with negative health outcomes among people who use drugs. This paper aims to estimate the incidence rate (initiation) and identify predictors of tranquilizer misuse (TM) among cocaine users.

Design And Methods: A prospective cohort study was conducted in Montreal, Canada. Read More

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http://dx.doi.org/10.1111/dar.12666DOI Listing
May 2018
3 Reads

A Fatty Acids Mixture Reduces Anxiety-Like Behaviors in Infant Rats Mediated by GABA Receptors.

Biomed Res Int 2017 17;2017:8798546. Epub 2017 Dec 17.

Laboratorio de Neurofarmacología, Instituto de Neuroetología, Universidad Veracruzana, 91190 Xalapa, VER, Mexico.

Fatty acids (C6-C18) found in human amniotic fluid, colostrum, and maternal milk reduce behavioral indicators of experimental anxiety in adult Wistar rats. Unknown, however, is whether the anxiolytic-like effects of fatty acids provide a natural mechanism against anxiety in young offspring. The present study assessed the anxiolytic-like effect of a mixture of lauric acid, myristic acid, palmitic acid, palmitoleic acid, stearic acid, oleic acid, elaidic acid, and linoleic acid in Wistar rats on postnatal day 28. Read More

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http://dx.doi.org/10.1155/2017/8798546DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748109PMC
August 2018
4 Reads

[Phenazepam: to the question of the efficacy and safety of benzodiazepine derivatives].

Authors:
A Yu Nenasteva

Zh Nevrol Psikhiatr Im S S Korsakova 2017;117(12):156-161

Serbsky Federal Medical Research Centre for Psychiatry and Narcology, Moscow, Russia; Sechenov First Moscow State Medical University, Moscow, Russia.

The widespread use of benzodiazepines in general medicalpractice in patients with complaints of anxiety and insomnia is due to a combination of efficacy and relative safety. Benzodiazepines have several advantages over other groups of sedatives: a wider range of doses between anxiolytic and sedative effect, a higher ratio between the average lethal and average effective doses, the lower risk of abuse. However, with prolonged use of even therapeutic doses of benzodiazepines (more than 6 months), the risk of dependence may increase - more often with the use of high-potency short-acting drugs. Read More

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http://dx.doi.org/10.17116/jnevro2017117121156-160DOI Listing
January 2019
1 Read

Hippocampal astrocyte atrophy in a mouse depression model induced by corticosterone is reversed by fluoxetine instead of benzodiazepine diazepam.

Prog Neuropsychopharmacol Biol Psychiatry 2018 04 3;83:99-109. Epub 2018 Feb 3.

Department of Pathology and Pathophysiology, School of Medicine and Life Sciences, Nanjing University of Chinese Medicine, Nanjing 210046, China.

Astrocytes have become promising new agents against major depressive disorders (MDD) primarily due to the crucial role they play in the pathogenesis of such disorders. However, a simple and reliable animal model that can be used to screen for astrocyte-targeting antidepressants has not yet been developed. In this study, we utilized a repeated corticosterone (CORT) injection paradigm to develop a mouse depression model wherein we examined the occurrence of alterations in hippocampal astrocyte population by using two astrocytic markers, namely, glial fibrillary acidic protein (GFAP) and S100β. Read More

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http://dx.doi.org/10.1016/j.pnpbp.2018.01.011DOI Listing
April 2018
6 Reads

Different effects of dexmedetomidine and midazolam on the expression of NR2B and GABAA-α1 following peripheral nerve injury in rats.

IUBMB Life 2018 02 17;70(2):143-152. Epub 2018 Jan 17.

Department of Anesthesiology, Kunming General Hospital of Chengdu Military Command, Kunming, China.

Neuropathic pain is a complex, chronic pain condition and the treatment is a major clinical challenge. Recent studies have shown that two FDA approved drugs dexmedetomidine (DEX) and midazolam (MZL), may be useful in treating neuropathic pain, but the mechanism is not fully dementated. Here, we investigated the effects and mechanisms of DEX and MZL treatment in the peripheral nerve injury model. Read More

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http://doi.wiley.com/10.1002/iub.1713
Publisher Site
http://dx.doi.org/10.1002/iub.1713DOI Listing
February 2018
13 Reads

Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data.

Cochrane Database Syst Rev 2017 12 15;12:CD011412. Epub 2017 Dec 15.

Department of Biostatistics, University of Liverpool, Block F, Waterhouse Building, 1-5 Brownlow Hill, Liverpool, UK, L69 3GL.

Background: Epilepsy is a common neurological condition with a worldwide prevalence of around 1%. Approximately 60% to 70% of people with epilepsy will achieve a longer-term remission from seizures, and most achieve that remission shortly after starting antiepileptic drug treatment. Most people with epilepsy are treated with a single antiepileptic drug (monotherapy) and current guidelines from the National Institute for Health and Care Excellence (NICE) in the United Kingdom for adults and children recommend carbamazepine or lamotrigine as first-line treatment for partial onset seizures and sodium valproate for generalised onset seizures; however a range of other antiepileptic drug (AED) treatments are available, and evidence is needed regarding their comparative effectiveness in order to inform treatment choices. Read More

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http://dx.doi.org/10.1002/14651858.CD011412.pub3DOI Listing
December 2017
31 Reads

Intermittent catatonia and complex automatisms caused by frontal lobe epilepsy in dementia.

BMJ Case Rep 2017 Dec 13;2017. Epub 2017 Dec 13.

Warneford Hospital, Oxford, UK.

An 82-year-old man was admitted to the emergency department following bizarre behaviour. Police had noticed him driving erratically through his village. He did not stop when instructed, drove slowly home and appeared 'vacant' on questioning. Read More

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http://dx.doi.org/10.1136/bcr-2017-222444DOI Listing
December 2017
11 Reads