127,417 results match your criteria Sedative Hypnotic Anxiolytic Use Disorders


Administration of the benzodiazepine midazolam increases tau phosphorylation in the mouse brain.

Neurobiol Aging 2018 Nov 8;75:11-24. Epub 2018 Nov 8.

Département de Psychiatrie et Neurosciences, Faculté de Médecine, Université Laval, Québec City, Québec, Canada; CRCHU, CHUL, Neurosciences, Québec City, Québec, Canada.

Preclinical studies have shown that anesthesia might accelerate the clinical progression of Alzheimer's disease (AD) and can have an impact on tau pathology, a hallmark of AD. Although benzodiazepines have been suggested to increase the risk of incident dementia, their impact on tau pathology in vivo is unknown. We thus examined the impact of midazolam, a benzodiazepine that is often administered perioperatively as an anxiolytic, on tau hyperphosphorylation in nontransgenic and in hTau mice, the latter a model of AD-like tau pathology. Read More

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November 2018

Treatment of an HIV-affected adolescent with heroin dependence in a low-income country: A clinical case study from Zambia.

Addict Behav Rep 2018 Dec 25;8:170-175. Epub 2018 Sep 25.

Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, 624 North Broadway, Baltimore, MD, 21205, United States of America.

Introduction: Although the World Health Organization (WHO) has recommended guidelines for the treatment of opioid dependence, there are myriad challenges to successfully implementing such guidelines in resource constrained settings, such as in low and middle-income countries (LMICs). To highlight these challenges, this paper presents a clinical case study of an adolescent study participant in a randomized controlled trial comparing two counseling programs in Lusaka, Zambia.

Case Description: This 15 year-old male reported smoking marijuana and heroin daily, and injecting heroin monthly (while needle sharing). Read More

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December 2018

Characterization of UV-Sensitive Marker Constituents of Polygala Root for TLC: Applications in Quality Control of Single Crude Drug Extract Preparations.

Chem Pharm Bull (Tokyo) 2018 ;66(12):1174-1180

Department of Pharmacognosy, College of Pharmaceutical Sciences, Matsuyama University.

Polygala Root (the root of Polygala tenuifolia WILLDENOW; Japanese name "Onji"), a well-known crude drug, traditionally used as an expectorant and sedative, has been attracting increased interest in recent years owing to its newly found pharmacological effect related to neuroprotection. However, there is no specific method for identifying and estimating the quality of this crude drug in the Japanese Pharmacopoeia, 17th edition. Therefore, in order to develop a TLC-based simple and convenient identification method using characteristic chemical marker(s) for the drug and its extract products, UV-sensitive constituents of Polygala Root were first investigated. Read More

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January 2018

Trends in Insomnia Diagnosis and Treatment Among Medicare Beneficiaries, 2006-2013.

Am J Geriatr Psychiatry 2018 Nov 2. Epub 2018 Nov 2.

Department of Neurology (SET), Columbia University, New York.

Objective: Insomnia is an important clinical problem affecting the elderly. We examined trends in insomnia diagnosis and treatment among Medicare beneficiaries over an eight-year period.

Methods: This was a time-series analysis of Medicare administrative data for years 2006-2013. Read More

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November 2018

Effects of dexmedetomidine and MK-467 on plasma glucose, insulin and glucagon in a glibenclamide-induced canine hypoglycaemia model.

Vet J 2018 Dec 21;242:33-38. Epub 2018 Sep 21.

Department of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, Viikintie 49, FI-00014 Helsinki, Finland.

The commonly used sedative α-adrenoceptor agonist dexmedetomidine has adverse cardiovascular effects in dogs that can be prevented by concomitant administration of the peripherally acting α-adrenoceptor antagonist MK-467. An ancillary effect of dexmedetomidine is to decrease insulin release from the pancreas, whereas MK-467 stimulates insulin release. This study assessed the effects of co-administered dexmedetomidine and MK-467 in a canine glibenclamide-induced hypoglycaemia model. Read More

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December 2018

Dexmedetomidine Use in a Tertiary Care NICU: A Descriptive Study.

Ann Pharmacother 2018 Dec 3:1060028018812089. Epub 2018 Dec 3.

2 Department of Peditrics, University of Calgary, Calgary, AB, Canada.

Background: Continuous infusions of dexmedetomidine are increasingly used for sedation in critically ill pediatric patients. Emerging data suggest potential benefits when used for sedation in neonates, including reduced sedative requirements and earlier enteral feeds.

Objective: To describe the use, adverse effects, and signs of withdrawal in a cohort of neonates receiving dexmedetomidine, the majority of whom were receiving concomitant opioids. Read More

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December 2018

Using sedative substances until death: A mortality follow-back study on the role of healthcare settings.

Palliat Med 2018 Dec 5:269216318815799. Epub 2018 Dec 5.

1 Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland.

Background:: In the last decade, the use of sedative substances to keep a patient in deep sedation until death increased fourfold in German-speaking Switzerland, where every third patient admitted to hospital, palliative care unit or hospice died continuously deeply sedated.

Aim:: To investigate sedation practices across healthcare settings and to identify their associations with conventional symptom control.

Design:: National mortality follow-back study in Switzerland between 2013 and 2014. Read More

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December 2018
1 Read

Using the Model for Improvement to implement the Critical-Care Pain Observation Tool in an adult intensive care unit.

BMJ Open Qual 2018 9;7(4):e000304. Epub 2018 Oct 9.

Department of Anaesthesia and Pain, Raigmore Hospital, Inverness, UK.

Managing pain is challenging in the intensive care unit (ICU) as often patients are unable to self-report due to the effects of sedation required for mechanical ventilation. Minimal sedative use and the utilisation of analgesia-first approaches are advocated as best practice to reduce unwanted effects of oversedation and poorly managed pain. Despite evidence-based recommendations, behavioural pain assessment tools are not readily implemented in many critical care units. Read More

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October 2018
4 Reads

Prehospital Airway Management in Iraq and Afghanistan: A Descriptive Analysis.

South Med J 2018 Dec;111(12):707-713

From the US Army Institute of Surgical Research, Joint Base San Antonio-Fort Sam Houston, Texas, the 59th Medical Wing, Joint Base San Antonio-Lackland Air Force Base, Texas, the San Antonio Military Medical Center, Joint Base San Antonio-Fort Sam Houston, Texas, the Madigan Army Medical Center, Joint Base Lewis McChord, Washington, and the Army Medical Department Center and School Health Readiness Center of Excellence, Joint Base San Antonio-Fort Sam Houston, Texas.

Objectives: Airway failures are the second leading cause of potentially preventable death on the battlefield. Improvements in airway management depend on identifying current challenges. We sought to build on previously reported data on prehospital, combat airway management. Read More

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December 2018
2 Reads

Population Pharmacokinetic/Pharmacodynamic Model-Guided Dosing Optimization of a Novel Sedative HR7056 in Chinese Healthy Subjects.

Front Pharmacol 2018 19;9:1316. Epub 2018 Nov 19.

Clinical Pharmacology Research Center, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.

HR7056 is a new benzodiazepine, showing more faster acting onset and recovery than currently available short-acting sedatives. To avoid inadequate anesthesia and predict return of cognition, allowing for immediate neurological evaluation, HR7056 pharmacokinetics and pharmacodynamics were characterized in Chinese healthy subjects. We report on modeling of the data and simulations of dosage regimens for future study. Read More

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November 2018

Pharmacists' interventions to reduce sedative/hypnotic use for insomnia in hospitalized patients.

Saudi Pharm J 2018 Dec 20;26(8):1204-1207. Epub 2018 Jul 20.

University of Arizona College of Pharmacy, USA.

Background: Hospitalization can contribute to insomnia in many patients and is usually treated symptomatically. However, sedative/hypnotic misuse is associated with complications in this population, especially in the elderly. Such complications include dizziness, falls and over-sedation. Read More

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December 2018
1 Read

Biological profiling of piperazinediones for the management of anxiety.

Pharmacol Biochem Behav 2018 Nov 27. Epub 2018 Nov 27.

Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi 221005, India. Electronic address:

The anxiolytic effect of the earlier reported piperazinediones was assessed by elevated plus maze (EPM), hole-board and open-field (OFT) tests. The rats were administered pretreatment of three different doses i.e. Read More

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November 2018
3 Reads

Effects of oral trazodone on echocardiographic and hemodynamic variables in healthy cats.

J Feline Med Surg 2018 Nov 30:1098612X18814565. Epub 2018 Nov 30.

Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois, Urbana, IL, USA.

Objectives: The purpose of this study was to evaluate the effects of oral trazodone on echocardiographic variables, heart rate (HR) and blood pressure (BP) in healthy cats.

Methods: Client-owned domestic cats between 2 and 8 years of age were recruited. Cats were considered healthy based on physical examination, complete blood count, blood chemistry profile, urinalysis, total thyroxine concentration, non-invasive BP measurement by Doppler method and a screening transthoracic echocardiogram with simultaneous electrocardiogram. Read More

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November 2018
1 Read

Comprehensive 3D-QSAR Model Predicts Binding Affinity of Structurally Diverse Sigma 1 Receptor Ligands.

J Chem Inf Model 2018 Nov 29. Epub 2018 Nov 29.

The Sigma 1 Receptor (S1R) has attracted intense interest as a pharmaceutical target for various therapeutic indications, including the treatment of neuropathic pain and the potentiation of opioid analgesia. Efforts by drug developers to rationally design S1R antagonists have been spurred recently by the 2016 publication of the high-resolution X-ray crystal structure of the ligand-bound human S1R. Until now, however, the absence in the published literature of a single, large-scale, and comprehensive quantitative structure-activity relationship (QSAR) model that encompasses a structurally diverse collection of S1R ligands has impaired rapid progress. Read More

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November 2018

Illustrations of the Sedative and Febrifuge Powers of Emetic Tartar.

Authors:
William Balfour

Lond Med Phys J 1824 Apr;51(302):276-283

the University of Edinburgh.

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Illustrations of the Sedative and Febrifuge Powers of Emetic Tartar.

Authors:
William Balfour

Lond Med Phys J 1824 May;51(303):380-389

the University of Edinburgh.

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Case of Tetanus Successfully Treated by Sedative Remedies.

Authors:
Cavallini

Lond Med Phys J 1820 Apr;43(254):289-290

Fulignano.

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Remarkable Effect Occasioned by a Sedative Poison.

Authors:
Tho Clark

Med Phys J 1812 Sep;28(163):172-180

No. 17, Denmark-street, Soho-square.

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September 1812

On Sedative Efficiency.

Authors:
Robert Kinglake

Med Phys J 1802 Jun;7(40):522-528

Chilton, super Polden.

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Potential of South African Medicinal plants targeting the reduction of Aβ42 Protein as a treatment of Alzheimer's disease.

J Ethnopharmacol 2018 Nov 26. Epub 2018 Nov 26.

Department of Chemistry, University of Pretoria and Natural Products Research Centre, Pretoria, South Africa. Electronic address:

Ethnopharmacological Relevance: Twenty South African medicinal plant species were selected by conducting a literature review based on the relevant information of their reported traditional medicinal uses and scientific reports against Alzheimer's disease, dementia, anxiety, mental illness, depression, acetylcholinesterase inhibition, headache, epilepsy, convulsion, hysteria, and sedative effects.

Aim Of Study: The goal of this study was to investigate the biological activity of the traditionally used medicinal plant extracts against Alzheimer's disease by in vitro screening of the extracts to determine their potential to decrease levels of Aβ42 protein.

Material And Methods: Different plant parts (leaves, stem, bark, and stalks) of twenty selected plants were collected from the Manie van der Schijff Botanical Garden, University of Pretoria. Read More

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November 2018
4 Reads

The α3β4 nicotinic acetylcholine receptor antagonist 18-Methoxycoronaridine decreases binge-like ethanol consumption in adult C57BL/6J mice.

Alcohol 2018 Nov 26. Epub 2018 Nov 26.

Department of Biobehavioral Health, The Pennsylvania State University, University Park, Pennsylvania, 16802, United States of America. Electronic address:

Binge alcohol drinking is a health burden in the United States which has an alarming economic impact. Unfortunately, medications available for alcohol abuse have low efficacy or adverse side effects creating a need to evaluate novel therapies. Growing research suggests that 18-Methoxycoronaridine (18-MC), an α3β4 nicotinic acetylcholine receptor (nAChR) antagonist, may be effective at reducing ethanol consumption. Read More

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November 2018
1 Read

Extended-release quetiapine overdose is associated with delayed onset of toxicity compared to immediate-release quetiapine overdose.

Emerg Med Australas 2018 Nov 28. Epub 2018 Nov 28.

Monash Emergency Research Collaborative, Department of Medicine, Clinical Sciences at Monash Health, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia.

Objectives: There are currently no studies comparing toxicity after extended-release (XR) and immediate-release (IR) quetiapine overdose. To compare the time course of toxicity of XR and IR quetiapine overdose.

Methods: Retrospective analysis of toxicology unit consultations from July 2013 to April 2016. Read More

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November 2018

Sedative and antinociceptive effects of different detomidine constant rate infusions, with or without methadone in standing horses.

Equine Vet J 2018 Nov 28. Epub 2018 Nov 28.

São Paulo State University (UNESP), School of Veterinary Medicine and Animal Science, Botucatu, SP, Brazil.

Background: Standing surgery avoids the risks of general anaesthesia in horses.

Objectives: To assess sedation, antinociception and gastrointestinal motility in standing horses after a detomidine loading dose and 2-hours constant rate intravenous (i.v. Read More

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November 2018

A Systematic Review and Narrative Synthesis on the histological and neurobehavioral long term effects of dexmedetomidine.

Paediatr Anaesth 2018 Nov 26. Epub 2018 Nov 26.

Department of Anesthesia, Sophia Children's Hospital, Erasmus MC Rotterdam, Netherlands.

Background: Recent experimental studies suggest that currently used anesthetics have neurotoxic effects on young animals. Clinical studies are increasingly published about the effects of anesthesia on the long term outcome, providing contradictory results. The selective alpha-2 adrenergic receptor agonist dexmedetomidine has been suggested as an alternative non-toxic sedative agent. Read More

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November 2018

Sedation and neurodevelopmental outcomes in PICU: identification of study groups.

Paediatr Anaesth 2018 Nov 25. Epub 2018 Nov 25.

Department of Anesthesia, Montreal Children's Hospital, McGill University, Canada.

Background/aims: As little as 30 minutes of exposure to anesthetic and sedative agents may adversely affect the developing brain. Safe, humane management of critically ill infants requires the use of sedative agents, often for prolonged periods. We sought to identify two comparable groups of critical care patients who did or did not receive sedatives, with the aim of designing a long-term neuro-development follow-up study. Read More

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November 2018
4 Reads

Effects of sleep disorders and sedative-hypnotic medications on health-related quality of life in dialysis patients.

Int Urol Nephrol 2018 Nov 22. Epub 2018 Nov 22.

Department of Nephrology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.

Purpose: Sleep disorders are very common among dialysis patients, leading patients to frequently take sedative-hypnotic medications; however, the effects of sleep disorders and the use of such drugs on health-related quality of life (HRQOL) have rarely been investigated.

Methods: The Pittsburgh Sleep Quality Index and Short Form-12 were used to assess sleep quality and patient health situations, respectively. Logistic regression was employed to identify factors associated with deterioration of the mental component summary (MCS) score and the physical component summary (PCS) score. Read More

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November 2018
2 Reads

Flavonoids isolated from Tibetan medicines, binding to GABA receptor and the anticonvulsant activity.

Phytomedicine 2018 Nov 18;50:1-7. Epub 2018 Sep 18.

Department of Molecular & Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA. Electronic address:

Background: Our previous studies on Asterothamnus centrali-asiaticus Novopokr. (ACN) and Arenaria kansuensis Maxim. (AKM) had led to the isolation of some phytochemical constituents and evaluation of anticonvulsant effect based on their extracts. Read More

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November 2018
2 Reads

Effect of dexmedetomidine on postoperative delirium in elderly patients undergoing hip fracture surgery.

Authors:
Shuyang Xie Min Xie

Pak J Pharm Sci 2018 Sep;31(5(Special)):2277-2281

Zhejiang Pharmaceutical College, Ningbo, Zhejiang, China.

Dexmedetomidine is a highly selective central α2 adrenergic receptor agonist, which has anti sympathetic, sedative and analgesic effects. The aim of this study was to investigate the effect of dexmedetomidine on postoperative delirium in elderly patients undergoing hip fracture surgery. The results showed that the dosage of sufentanil and propofol decreased significantly in the experimental group (P<0. Read More

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September 2018
1 Read

Postoperative analgesic effect of different doses of naloxone combined with butorphanol and psychological nursing intervention.

Pak J Pharm Sci 2018 Sep;31(5(Special)):2229-2234

Operation room, Weihai Central Hospital of Shandong Province, Wendeng, China.

Cesarean section, as a stressor, inevitably produces negative emotions such as anxiety and may cause intraoperative discomfort and postoperative pain. Butorphanol is a commonly used analgesic in cesarean section. Butorphanol's postoperative analgesia can reduce the incidence of postoperative respiratory depression and play a good sedative effect. Read More

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September 2018
2 Reads

Pharmacological analysis of dexmedetomidine hydrochloride in pediatric anesthesia during magnetic resonance imaging.

Pak J Pharm Sci 2018 Sep;31(5(Special)):2209-2214

Department of Anesthesiology, Qilu Hospital of Shandong University, Jinan, China.

Dexmendetomidine hydrochloride (DEX) is a new common adrenergic receptor agonist, which not only keeps children calm but also has analgesic effect. Dexmedetomidine hydrochloride will enable children to maintain the natural non-REM sleep, which can be stimulated sedation or language arousal. The aim of this study is to observe the sedative effect and adverse drug reactions of dexmedetomidine hydrochloride injection and propofol injection in MRI examination. Read More

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September 2018

Nebulization versus standard application for topical anaesthesia during flexible bronchoscopy under moderate sedation - a randomized controlled trial.

Respir Res 2018 Nov 21;19(1):227. Epub 2018 Nov 21.

Department of Pneumology and Intensive Care Medicine, University Hospital RWTH Aachen, Pauwelsstraße 30, 52074, Aachen, Germany.

Background: Endobronchial administration of lidocaine is commonly used for cough suppression during diagnostic bronchoscopy. Recently, nebulization of lidocaine during bronchoscopies under deep sedation with fiberoptic intubation using a distinct spray catheter has been shown to have several advantages over conventional lidocaine administration via syringe. However, there are no data about this approach in bronchoscopies performed under moderate sedation. Read More

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November 2018
1 Read

Equipment failure of intravenous syringe pump detected by increase in Narcotrend stage: A case report.

Medicine (Baltimore) 2018 Nov;97(47):e13174

Department of Anesthesiology, the First Hospital of Jilin University, Changchun, People's Republic of China.

Rationale: Awareness is the recovery of consciousness during general anesthesia. It occurs when patients under general anesthesia receive inadequate anesthetic medications to maintain unconsciousness during surgery. Equipment failure is a common cause of intraoperative awareness. Read More

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November 2018
3 Reads

Reduction of oxidative stress a key for enhanced postoperative recovery with fewer complications in esophageal surgery patients: Randomized control trial to investigate therapeutic impact of anesthesia management and usefulness of simple blood test for prediction of high-risk patients.

Medicine (Baltimore) 2018 Nov;97(47):e12845

Department of Anesthesiology, Osaka City University Graduate School of Medicine.

Background: Oxidative stress may be an integral determinant of surgical stress severity. We examined whether the preoperative level of derivatives of reactive oxygen metabolites (d-ROMs), an oxidative stress biomarker based on total hydroperoxides in circulating blood, is predictive of increased risk of delayed recovery and complications after surgery, as well as the effects of anesthesia management on postoperative recovery in light of oxidative stress.

Methods: Patients (American Society of Anesthesiologists physical status I-II) scheduled for a radical esophagectomy (n = 186) were randomly selected to receive inhalational sevoflurane (n = 94) or intravenous propofol (n = 92) anesthesia. Read More

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November 2018
2 Reads

Therapeutic potential of mistletoe in CNS-related neurological disorders and the chemical composition of Viscum species.

J Ethnopharmacol 2018 Nov 17;231:241-252. Epub 2018 Nov 17.

Department of Spectrometric Methods, National Medicines Institute, Chełmska 30/34, 00-725 Warsaw, Poland. Electronic address:

Ethnopharmacological Relevance: Viscum album L., commonly known as mistletoe, has been used for centuries in traditional medicine to treat various neurological diseases, including epilepsy, hysteria, nervousness, hysterical psychosis, dizziness and headaches.

Aim Of The Study: The aim of this review is to summarize existing evidence confirming the influence of mistletoe on the central nervous system and to investigate the compounds that may be responsible for this activity. Read More

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November 2018
4 Reads

Sedative and cardiopulmonary effects of buccally administered detomidine gel and reversal with atipamezole in dogs.

Am J Vet Res 2018 Dec;79(12):1253-1260

OBJECTIVE To evaluate hemodynamic, respiratory, and sedative effects of buccally administered detomidine gel and reversal with atipamezole in dogs. ANIMALS 8 adult purpose-bred dogs. PROCEDURES Arterial and venous catheters were placed. Read More

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December 2018

Evaluation of the thermal antinociceptive effects and pharmacokinetics after intramuscular administration of buprenorphine hydrochloride to cockatiels (Nymphicus hollandicus).

Am J Vet Res 2018 Dec;79(12):1239-1245

OBJECTIVE To evaluate thermal antinociceptive effects and pharmacokinetics of buprenorphine hydrochloride after IM administration to cockatiels (Nymphicus hollandicus). ANIMALS 16 adult (≥ 2 years old) cockatiels (8 males and 8 females). PROCEDURES Buprenorphine hydrochloride (0. Read More

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December 2018
1 Read

Efficacy of autofluorescence imaging for flat neoplasm detection: a multicenter randomized controlled trial (A-FLAT trial).

Gastrointest Endosc 2018 Nov 16. Epub 2018 Nov 16.

Endoscopy Division, National Cancer Center Hospital, Japan.

Background & Aims: Colorectal flat (nonpolypoid) lesions can be overlooked during colonoscopy. This study evaluated the efficacy of updated autofluorescence imaging (AFI) for detecting colorectal flat neoplasms.

Methods: This was a prospective, multicenter, randomized controlled trial in 9 Japanese tertiary institutions. Read More

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November 2018
4 Reads

Tocolytic activity of the Lippia alba essential oil and its major constituents, citral and limonene, on the isolated uterus of rats.

Chem Biol Interact 2018 Nov 14;297:155-159. Epub 2018 Nov 14.

Biological Chemistry Department, Postgraduate Program in Biological Chemistry, Regional University of Cariri, Pimenta Campus, 63105-010, Crato, CE, Brazil. Electronic address:

The species Lippia alba (Mill.) N. E. Read More

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November 2018
2 Reads

Multidisciplinary Investigations on : A Mexican Medicinal Plant with Pharmacological Potential.

Molecules 2018 Nov 15;23(11). Epub 2018 Nov 15.

Centro de Investigación en Biotecnología (CEIB), Universidad Autónoma del Estado de Morelos (UAEM), Cuernavaca CP 62209, Mexico.

(Cav.) Kuntze is an important endemic plant species, which possesses many medicinal properties and has been used in the Mexican traditional medicine for its sedative, anxiolytic, anticonvulsant, antiasthmatic and antiallergic properties. The therapeutic properties of this plant are mainly due to the presence of diverse bioactive compounds such as flavonoids, triterpenoids, and phenolics. Read More

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November 2018
5 Reads
2.420 Impact Factor

Comparison of sedative effects of oral midazolam/chloral hydrate and midazolam/promethazine in pediatric dentistry.

J Dent Res Dent Clin Dent Prospects 2018 18;12(3):221-226. Epub 2018 Sep 18.

Private Practice, Kerman, Iran.

The aim of this investigation was to compare the sedative effects of oral midazolam/chloral hydrate and midazolam/promethazine combinations on fearful children needing dental treatment. This crossover double-blind clinical trial was conducted on 30 children aged 2‒6 years, who had at least two similar teeth needing pulp treatment. Standard vital signs were recorded before and after premedication. Read More

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September 2018
3 Reads

Sleep Quality and Sleep Duration with CKD are Associated with Progression to ESKD.

Clin J Am Soc Nephrol 2018 Nov 15. Epub 2018 Nov 15.

Yaizu City Hospital, Yaizu, Shizuoka, Japan.

Background And Objectives: Shorter or longer sleep duration and poor sleep quality are risk factors for numerous cardio-metabolic diseases, cardiovascular disease, and mortality in subjects with normal kidney function. The association of sleep duration and sleep quality with health outcomes in patients with CKD remains uncertain.

Design, Setting, Participants, & Measurements: A 4-year prospective cohort study in 17 nephrology centers in Japan, the CKD Japan Cohort (CKD-JAC) Study, assessed an association of self-reported sleep duration and sleep quality, on the basis of the Pittsburgh Sleep Quality Index (PSQI) questionnaire, with incidence of ESKD in 1601 patients with eGFR 10-59 ml/min per 1. Read More

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November 2018
3 Reads

Neuroprotection by anaesthetics in rodent models of traumatic brain injury: a systematic review and network meta-analysis.

Br J Anaesth 2018 Dec 1;121(6):1272-1281. Epub 2018 Sep 1.

Biostatistics Research Group, Department of Health Sciences, University of Leicester, Leicester, UK.

Background: Anaesthetic neuroprotection in the setting of traumatic brain injury (TBI) remains unproved and is based upon the results in preclinical experiments. Here, we sought to synthesise the results in rodent models of TBI, and to evaluate the effects of publication bias, experimental manipulation, and poor study quality on the effect estimates.

Methods: After a systematic review, we used pairwise meta-analysis to estimate the effect of anaesthetics, opioids, and sedative-hypnotics on neurological outcome, and network meta-analysis to compare their relative efficacy. Read More

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December 2018
1 Read

Chemical Profiles of Incense Smoke Ingredients from Agarwood by Headspace Gas Chromatography-Tandem Mass Spectrometry.

Molecules 2018 Nov 14;23(11). Epub 2018 Nov 14.

Department of Biochemical Science and Technology, National Taiwan University, Taipei 10617, Taiwan.

Agarwood, the resinous wood in the heartwood of trees, has been used as incense in traditional Chinese medicine for its sedative, aphrodisiac, carminative, and anti-emetic effects. Grading of agarwood is usually based on its physical properties. Therefore, it is important to develop analytic methods for judgment and grading of agarwood. Read More

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November 2018
4 Reads

Conditional probabilities of substance use disorders and associated risk factors: Progression from first use to use disorder on alcohol, cannabis, stimulants, sedatives and opioids.

Drug Alcohol Depend 2018 Nov 3;194:136-142. Epub 2018 Nov 3.

National Drug and Alcohol Research Centre, University of New South Wales, NSW 2052, Sydney, Australia; NHMRC Centre of Research Excellence in Mental Health and Substance Use, University of New South Wales, NSW 2052, Sydney, Australia.

Background: Relatively little is known about factors that may lead to the development of a substance use disorder (SUD), across a range of drug classes. This study aimed to identify factors that predict the likelihood of transition from use to SUD and the speed with which this may occur at the population level, with a focus on the impact of pre-existing mental disorders.

Methods: Data were collected as part of the 2007 Australian National Survey of Mental Health and Wellbeing, a nationally representative survey of 8841 Australian adults. Read More

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November 2018
3 Reads

[Comparison of two schemes of daily arousal and comfort analgesia and sedation in patients on mechanical ventilation in intensive care unit].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2018 Oct;30(10):950-952

Department of Intensive Care Unit, Pingxiang People's Hospital, Pingxiang 337000, Jiangxi, China. Corresponding author: Guo Kun, Email:

Objective: To explore the efficacy of comfort analgesia and sedation in patients with mechanical ventilation in intensive care unit (ICU).

Methods: Eighty patients with mechanical ventilation admitted to ICU of Pingxiang People's Hospital from June 2017 to May 2018 were enrolled, and they were randomly divided into control group and observation group by random number table method, with 40 patients in each group. The control group was given a daily analgesic and sedation regimen with critical-care pain observation tool (CPOT) 0-3 and Richmond agitation-sedation scale (RASS) maintained at -3 to -4. Read More

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October 2018
1 Read

[Risk factors and etiological analysis of ventilator-associated pneumonia: three year's cases analysis of intensive care unit in county hospital].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2018 Oct;30(10):933-938

Department of ICU, Shexian People's Hospital, Huangshan 245200, Anhui, China (Hu ZC); Department of ICU, First Affiliated Hospital of China University of Science and Technology, Hefei 230001, Anhui, China (Zhou SS). Corresponding author: Zhou Shusheng, Email:

Objective: To investigate the risk factors of ventilator-associated pneumonia (VAP) and the distribution and drug resistance of pathogens in intensive care unit (ICU) of county hospital.

Methods: 234 patients on mechanical ventilation for more than 48 hours admitted to ICU of Shexian People's Hospital of Huangshan City from January 2016 to June 2018 were enrolled. The clinical data of all patients including gender, age, past medical history, exposure to antibiotics, medication, the duration of mechanical ventilation, the length of ICU stay, serum albumin, tracheotomy, re-intubation, prognosis, and pathogenic bacteria and drug sensitivity test of VAP patients were collected. Read More

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October 2018
4 Reads

Clinical effectiveness of parenteral trazodone for the management of psychomotor activation in patients with bipolar disorder.

Neuro Endocrinol Lett 2018 Sep 4;39(3):205-208. Epub 2018 Sep 4.

Department of Molecular Medicine and Clinical Department of Mental Health, University of Siena, Siena, Italy.

Objectives: Trazodone is a multifunctional triazolopyridine drug with antidepressant, anxiolytic, sedative, and hypnotic properties. The current retrospective study was designed to investigate the effectiveness of trazodone for reducing acute psychomotor activation (PA) in patients with bipolar disorder (BD). We specifically reasoned that a parenteral route of administration could offer potential advantages in this clinical setting. Read More

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September 2018
5 Reads

Effect of prophylactic palonosetron and sugammadex on postoperative nausea and vomiting in patients undergoing microvascular decompression under propofol-maintained anesthesia: A retrospective observational study.

Medicine (Baltimore) 2018 Nov;97(46):e13237

Department of Anesthesiology and Pain Medicine, College of Medicine, Kyung Hee University, Seoul, Korea.

Microvascular decompression (MVD) is associated with a particularly high risk of postoperative nausea and vomiting (PONV) among craniotomy patients. However, there is no information regarding the effect of prophylactic palonosetron and sugammadex on PONV in patients undergoing MVD under propofol-maintained anesthesia.Medical records of 274 adults who had undergone MVD under propofol-maintained anesthesia were reviewed. Read More

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November 2018

Designer benzodiazepines: a report of exposures recorded in the National Poison Data System, 2014-2017.

Clin Toxicol (Phila) 2018 Nov 15:1-5. Epub 2018 Nov 15.

a Georgia Poison Center , Atlanta , GA , USA.

Importance: Exposures to novel psychoactive substances are reported with increasing frequency in both the medical literature and the lay press. While the majority of reports describe synthetic cannabinoids and cathinones, a lesser understood family is the "designer benzodiazepines". The current literature describing human exposures to these compounds is comprised of case reports and small case series. Read More

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November 2018
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