Am J Psychiatry 2021 04 3;178(4):352-362. Epub 2021 Mar 3.
Yale Child Study Center (Dwyer, Landeros-Weisenberger, Johnson, Londono Tobon, Flores, Nasir, Bloch), Department of Radiology and Biomedical Imaging (Dwyer), and Department of Psychiatry (Londono Tobon, Flores, Sanacora, Bloch), Yale School of Medicine, New Haven, Conn.; Department of Pediatrics, Stanford University, Stanford, Calif. (Couloures).
Objective: Adolescent depression is prevalent and is associated with significant morbidity and mortality. Although intravenous ketamine has shown efficacy in adult treatment-resistant depression, its efficacy in pediatric populations is unknown. The authors conducted an active-placebo-controlled study of ketamine's safety and efficacy in adolescents. Read More