8,015 results match your criteria Sedative Hypnotic Anxiolytic Use Disorders


Withdrawal and Misuse Concerns of Consumers regarding Opioid Analgesic and Anxiolytic, Hypnotic and Sedative Medicines.

Subst Use Misuse 2020 Jul 2:1-13. Epub 2020 Jul 2.

School of Pharmacy, The University of Queensland, Woolloongabba, Queensland, Australia.

Opioid analgesic (OA) and anxiolytic, hypnotic and sedative (AHS) medicines use raise community concerns about risks of dependence: dose escalation, unintentional misuse. We aimed to identify common consumer OA and AHS information gaps and concerns that led to information seeking from a hotline. We conducted a retrospective, mixed-method observational study of consumers' OA and AHS-related calls to an Australian national medicines call center (September 2002-30 June 2010). Read More

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http://dx.doi.org/10.1080/10826084.2020.1784948DOI Listing

Anxiolytic-like activity of 5-methoxyflavone in mice with involvement of GABAergic and serotonergic systems - in vivo and in silico evidences.

Eur Neuropsychopharmacol 2020 Jun 10. Epub 2020 Jun 10.

Department of Pharmaceutical Chemistry, VISTAS, VELS school of Pharmaceutical Sciences, Chennai 600117, Tamilnadu, India.

Anxiety disorders are common worldwide and novel compounds are investigated for anxiolytic effect. A few studies have demonstrated the anxiolytic-like activity of natural and synthetic flavonoids. 5-methoxyflavone, a synthetic flavone derivative, has been reported to exhibit central nervous system depressant (sedative-hypnotic) effect in an earlier study. Read More

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http://dx.doi.org/10.1016/j.euroneuro.2020.05.009DOI Listing

[Survey of anxiolytic drug dependence in patients treated in psychiatric and addiction rehabilitation wards].

Orv Hetil 2020 04 1;161(15):594-600. Epub 2020 Apr 1.

Jahn Ferenc Dél-pesti Kórház és Rendelőintézet, Budapest, Köves út 1., 1204.

Introduction: Anxiolytic drug dependence is a cause for growing concern worldwide including Hungary. Psychiatric patients and patients with other drug addictions are at increased risk for anxiolytic drug dependence. Yet, there is only limited scientific information about the real extent of this issue. Read More

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http://dx.doi.org/10.1556/650.2020.31720DOI Listing

Isolated stridor without any other sleeping breathing disorder diagnosed using drug-induced sleep endoscopy in a patient with multiple system atrophy: A case report.

Medicine (Baltimore) 2020 Apr;99(16):e19745

Department of Physical Medicine and Rehabilitation, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Republic of Korea.

Rationale: Multiple system atrophy (MSA) is a rare neurodegenerative disease characterized by Parkinsonism and autonomic dysfunction or cerebellar ataxia. MSA can be accompanied by stridor caused by laryngeal stenosis secondary to vocal cord dysfunction.

Patient Concern: A 60-year-old woman with MSA, complaining of difficulty in breathing during sleep. Read More

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http://dx.doi.org/10.1097/MD.0000000000019745DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220077PMC

Effects of plasma concentration of micro-RNA Mir-27b and CYP3A4*22 on equilibrium concentration of alprazolam in patients with anxiety disorders comorbid with alcohol use disorder.

Gene 2020 May 26;739:144513. Epub 2020 Feb 26.

Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation, 2/1 Barrikadnaya Street, Moscow 123995, Russian Federation.

Alprazolam is used in the treatment of patients with anxiety disorders comorbid with alcohol use disorder. Some proportion of these patients does not respond adequately to treatment with alprazolam, while many of them experience dose-dependent adverse drug reactions. Results of the previous studies have shown that CYP3A is involved in the biotransformation of alprazolam, the activity of which is dependent, inter alia, on the polymorphism of the encoding gene. Read More

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http://dx.doi.org/10.1016/j.gene.2020.144513DOI Listing

[Application of intravenous sedation in 2 582 cases of oral and maxillofacial surgery].

Beijing Da Xue Xue Bao Yi Xue Ban 2020 Feb;52(1):181-186

Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China.

Objective: To analyze the clinical data of patients undergoing intravenous sedation in oral and maxillofacial surgery, to understand the epidemiological characteristics, to evaluate the efficacy and safety of intravenous sedation for oral surgery, and to summarize our experience.

Methods: We retrospectively reviewed the clinical data of patients undergoing intravenous sedation between January 2010 and December 2018 in the Department of Oral and Maxillofacial Surgery, Peking University School of Stomatology. The gender, age, source, disease types, the values of perioperative vital signs, the use of sedatives and analgesics, duration of surgery and sedation, effect of sedation during the operation and the postoperative anterograde amnesia were analyzed. Read More

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February 2020

An improved cytochrome P450 phenotyping cocktail with a simplified and highly sensitive UHPLC-MS/MS assay in human plasma.

J Chromatogr B Analyt Technol Biomed Life Sci 2020 Mar 1;1140:122013. Epub 2020 Feb 1.

Faculty of Medicine and Health, School of Pharmacy, University of Sydney, Sydney, Australia; Centre for Education and Research on Ageing, Concord Repatriation General Hospital, Concord, Australia. Electronic address:

Measuring in vivo changes in the drug metabolizing activity of cytochrome P450 (CYP) enzymes is critical to understanding and assessing drug-drug, drug-diet and drug-disease interactions. The sensitivity and specificity of ultra-high-performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) makes it an ideal tool for analyzing drugs and their metabolites in biological matrices, and has demonstrated utility in CYP phenotyping across varied applications. Published CYP phenotyping cocktail assays often require large plasma sample volumes (0. Read More

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http://dx.doi.org/10.1016/j.jchromb.2020.122013DOI Listing

[On the issue of the detection of pregabalin and lorazepam in the cases of their joint presence for the purpose of chemical toxicological studies].

Sud Med Ekspert 2020 ;63(1):36-41

FSBI 'Russian Center for Forensic Medical Examination' of the Ministry of Health of Russia, Moscow, Russia, 125284.

Data on the detection of joint presence of pregabalin and lorazepam in the biological objects and material evidence. Aim of this study is to develop a method of the detection of pregabalin and lorazepam in urine. The proposed approach to sample preparation of a biological object and the detection of lorazepam and pregabalin allows the detection of toxicants in cases of their joint presence. Read More

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http://dx.doi.org/10.17116/sudmed20206301136DOI Listing

Ketamine Plus Motivational Enhancement Therapy: Leveraging a Rapid Effect to Promote Enduring Change.

Am J Psychiatry 2020 02;177(2):107-109

The Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, and the Michael E. DeBakey VA Medical Center, Houston (Mathew); and the Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh (Price).

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http://dx.doi.org/10.1176/appi.ajp.2019.19121242DOI Listing
February 2020

Benzodiazepine Use Among Resident Doctors In Tertiary Care Hospital.

J Ayub Med Coll Abbottabad 2019 Oct-Dec;31(4):553-557

Department of Pharmacology, Ayub Teaching Hospital, Abbottabad, Pakistan.

Background: Benzodiazepines (BZD) are some of the most common medications in the world. Benzodiazepines useful in treating anxiety, insomnia, agitation, seizures, muscle spasms, alcohol withdrawal. Benzodiazepines are generally considered safe and well tolerated but are commonly misused and taken in combination with other drugs of abuse. Read More

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Post-traumatic stress disorder or emergence phenomena? A case of psychomotor agitation after procedural sedation and analgesia.

Drug Metab Pers Ther 2019 12;34(4)

Tehran University of Medical Sciences, Tehran, Iran.

Background Psychomotor agitation can be problematic in an overcrowded emergency department (ED) during uncontrolled procedural sedation. Although emergence phenomena have been studied, various presentations may exist. Case presentation During procedural sedation, a 58-year-old man was sedated with a dissociative dose of ketamine in conjunction with propofol. Read More

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http://dx.doi.org/10.1515/dmpt-2019-0024DOI Listing
December 2019

New approach for detoxification of patients dependent on benzodiazepines and Z-drugs for reduction of psychogenic complications.

Ceska Slov Farm 2019 ;68(4):139-147

Benzodiazepines (BZDs) and Z-drugs are strongly addictive substances, acting on identical GABA receptors. Detoxification should be long-term and gradual, usually by tapering a long-acting BZD (diazepam) but no suitable commercial pharmaceutic product exists with the necessary low drug content. This review describes the specific pharmacological aspects and comparisons of individual BZDs in relation to their effects and addictiveness. Read More

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December 2019

Comparison of the effects of a dexmedetomidine-ketamine-midazolam anesthetic protocol versus isoflurane inhalation anesthesia on echocardiography variables and plasma cardiac troponin I concentration in black-tailed prairie dogs ().

Am J Vet Res 2019 Dec;80(12):1114-1121

Objective: To compare the effects of a dexmedetomidine-ketamine-midazolam (DKM) anesthetic protocol versus isoflurane inhalation anesthesia on echocardiographic variables and plasma cardiac troponin 1 (cTnI) concentration in black-tailed prairie dogs (BTPDs; ).

Animals: Nine 6-month-old sexually intact male captive BTPDs.

Procedures: Each BTPD was randomly assigned to be anesthetized by IM administration of dexmedetomidine (0. Read More

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http://dx.doi.org/10.2460/ajvr.80.12.1114DOI Listing
December 2019

Benzodiazepine Use Is Associated With an Increased Risk of Neurocognitive Impairment in People Living With HIV.

J Acquir Immune Defic Syndr 2019 12;82(5):475-482

Department of Psychiatry, University of California, San Diego, CA.

Objective: Despite potential for dependence and adverse neurological effects, long-term benzodiazepine (BZD) use is common among people living with HIV (PLWH). As PLWH are at risk for central nervous system dysfunction, we retrospectively examined the association between BZD use and HIV-associated neurocognitive impairment (NCI).

Methods: Three hundred six PLWH underwent comprehensive neurobehavioral evaluations. Read More

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http://dx.doi.org/10.1097/QAI.0000000000002183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857713PMC
December 2019

Pathophysiology of and therapeutic options for a GABRA1 variant linked to epileptic encephalopathy.

Mol Brain 2019 11 10;12(1):92. Epub 2019 Nov 10.

Djavad Mowafaghian Centre for Brain Health and Department of Medicine, University of British Columbia, Vancouver, Canada.

We report the identification of a de novo GABRA1 (R214C) variant in a child with epileptic encephalopathy (EE), describe its functional characterization and pathophysiology, and evaluate its potential therapeutic options. The GABRA1 (R214C) variant was identified using whole exome sequencing, and the pathogenic effect of this mutation was investigated by comparing wild-type (WT) α1 and R214C α1 GABA receptor-expressing HEK cells. GABA-evoked currents in these cells were recorded using whole-cell, outside-out macro-patch and cell-attached single-channel patch-clamp recordings. Read More

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http://dx.doi.org/10.1186/s13041-019-0513-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6842544PMC
November 2019

Retrospective evaluation of prazosin and diazepam after thoracolumbar hemilaminectomy in dogs.

Vet J 2019 Nov 13;253:105377. Epub 2019 Sep 13.

Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University, Skip Bertman Drive, Baton Rouge, LA 70803, USA.

Management of urinary retention after spinal cord injury in dogs is often needed and can include use of medications to relax the urethral sphincter. This was a retrospective study evaluating two such medications, prazosin and diazepam, and whether dogs treated with these medications had different lengths of hospitalization, urinary continence levels, or development of bacteriuria compared to dogs not receiving these medications after thoracolumbar hemilaminectomy for intervertebral disc herniation (IVDH). Electronic medical records were searched for dogs that underwent CT or MRI followed by a hemilaminectomy between the 3 thoracic and 3rd lumbar vertebra for treatment of IVDH. Read More

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http://dx.doi.org/10.1016/j.tvjl.2019.105377DOI Listing
November 2019

A Medical Review of Fatal High-G U.S. Aerobatic Accidents.

Aerosp Med Hum Perform 2019 Nov;90(11):959-965

Exposure to high G force is a known safety hazard in military aviation as well as civilian aerobatic flight. Tolerance to high G forces has been well studied in military pilots, but there is little research directed at civilian pilots who may have medications or medical conditions not permitted in military pilots. In this case-control study, we identified 89 fatal high-G aerobatic accidents and 4000 fatal control accidents from 1995 through 2018 from the NTSB accident database and the FAA autopsy database. Read More

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http://dx.doi.org/10.3357/AMHP.5445.2019DOI Listing
November 2019

Treatment of first-episode psychosis in patients with autism-spectrum disorder and intellectual deficiency

J Psychiatry Neurosci 2019 Nov;44(6):E31-E32

From the psychiatry residency program, McGill University (Garel); and McGill University, Douglas Mental Health University Institute (Joober), Montreal, Que., Canada.

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http://dx.doi.org/10.1503/jpn.190081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6821509PMC
November 2019

Acute kidney injury, seizures, and hypertonic hyponatremia secondary to mannitol intoxication in a dog.

J Vet Emerg Crit Care (San Antonio) 2019 Nov 21;29(6):680-685. Epub 2019 Oct 21.

Unité Urgences et soins intensifs, Ecole Nationale Vétérinaire de Toulouse, Toulouse Cedex 03, France.

Objective: To describe a case of mannitol overdose associated with acute kidney injury (AKI), hypertonic hyponatremia, and neurologic abnormalities in a dog.

Case Summary: A 10-year-old intact male Shiba Inu dog was referred to the emergency service of a veterinary teaching hospital for inappetence and acute onset of seizures. The dog had received 2 IV boluses of 3 g/kg of mannitol in less than 24 hours for a glaucoma crisis. Read More

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http://dx.doi.org/10.1111/vec.12902DOI Listing
November 2019
1 Read

Sedative depth on neurological outcomes in a juvenile rat model of cardiopulmonary resuscitation.

Med Hypotheses 2019 Nov 20;132:109233. Epub 2019 May 20.

Department of Orthopedics, Shuangliu First People's Hospital, Chengdu 610200, Sichuan, China. Electronic address:

The guidelines for cardiopulmonary resuscitation (CPR) in pediatric advanced life support suggest that midazolam is the preferred agent for sedation in patients with mild hypothermia, whereas children with cardiac arrest (CA) are at a crucial stage regarding their immature nervous system. Studies have shown that midazolam may have a detrimental effect on the developmental of the pediatric nervous system. Our previous study found that midazolam induced neuronal damage after CPR in young rats. Read More

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http://dx.doi.org/10.1016/j.mehy.2019.109233DOI Listing
November 2019
1 Read

Shisa7 is a GABA receptor auxiliary subunit controlling benzodiazepine actions.

Science 2019 10;366(6462):246-250

Synapse and Neural Circuit Research Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.

The function and pharmacology of γ-aminobutyric acid type A receptors (GABARs) are of great physiological and clinical importance and have long been thought to be determined by the channel pore-forming subunits. We discovered that Shisa7, a single-passing transmembrane protein, localizes at GABAergic inhibitory synapses and interacts with GABARs. Shisa7 controls receptor abundance at synapses and speeds up the channel deactivation kinetics. Read More

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http://dx.doi.org/10.1126/science.aax5719DOI Listing
October 2019
3 Reads
31.477 Impact Factor

Effects of dexmedetomidine on post-operative recovery and mental status in patients receiving robotic-assisted thoracic surgery.

Ann Palliat Med 2019 Sep;8(4):469-475

Department of Anesthesiology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China.

Background: This study aimed to investigate the effects of dexmedetomidine on the post-operative recovery and mental status in patients receiving robotic-assisted thoracic surgery (RATS).

Methods: One hundred patients who received selective RATS under general anesthesia were recruited and assigned into control group (C) and dexmedetomidine group (D). The anesthesia induction and maintenance were consistent between groups. Read More

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http://dx.doi.org/10.21037/apm.2019.08.09DOI Listing
September 2019
2 Reads

Medicines associated with dependence or withdrawal: a mixed-methods public health review and national database study in England.

Lancet Psychiatry 2019 11 3;6(11):935-950. Epub 2019 Oct 3.

Alcohol, Drugs, Tobacco and Justice Division, Health Improvement Directorate, Public Health England, London, UK.

Background: Antidepressants, opioids for non-cancer pain, gabapentinoids (gabapentin and pregabalin), benzodiazepines, and Z-drugs (zopiclone, zaleplon, and zolpidem) are commonly prescribed medicine classes associated with a risk of dependence or withdrawal. We aimed to review the evidence for these harms and estimate the prevalence of dispensed prescriptions, their geographical distribution, and duration of continuous receipt using all patient-linked prescription data in England.

Methods: This was a mixed-methods public health review, comprising a rapid evidence assessment of articles (Jan 1, 2008, to Oct 3, 2018; with searches of MEDLINE, Embase, and PsycINFO, and the Cochrane and King's Fund libraries), an open call-for-evidence on patient experience and service evaluations, and a retrospective, patient-linked analysis of the National Health Service (NHS) Business Services Authority prescription database (April 1, 2015, to March 30, 2018) for all adults aged 18 years and over. Read More

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http://dx.doi.org/10.1016/S2215-0366(19)30331-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7029276PMC
November 2019

Sedation with Propofol During Catheter-Directed Thrombolysis for Acute Submassive Pulmonary Embolism Is Associated with Increased Mortality.

J Vasc Interv Radiol 2019 Nov 3;30(11):1719-1724. Epub 2019 Oct 3.

Department of Radiology, AdventHealth Medical Group, AdventHealth Orlando, 601 E. Rollins Street, Orlando, FL 32803. Electronic address:

Purpose: To evaluate if sedation with propofol during catheter-directed thrombolysis (CDT) in patients with acute submassive pulmonary embolism (PE) affects survival.

Materials And Methods: This single-institution, retrospective study identified 136 patients from 2011-2017 who underwent CDT for acute submassive PE. Patients were grouped based on procedural sedation-propofol versus fentanyl and/or midazolam. Read More

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http://dx.doi.org/10.1016/j.jvir.2019.08.009DOI Listing
November 2019
4 Reads

Comparison of intranasal versus intravenous midazolam for management of status epilepticus in dogs: A multi-center randomized parallel group clinical study.

J Vet Intern Med 2019 Nov 3;33(6):2709-2717. Epub 2019 Oct 3.

Small Animal Department, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.

Background: The intranasal (IN) route for rapid drug administration in patients with brain disorders, including status epilepticus, has been investigated. Status epilepticus is an emergency, and the IN route offers a valuable alternative to other routes, especially when these fail.

Objectives: To compare IN versus IV midazolam (MDZ) at the same dosage (0. Read More

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http://dx.doi.org/10.1111/jvim.15627DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6872604PMC
November 2019
2 Reads

Effect of renal ischaemia/reperfusion-induced acute kidney injury on pharmacokinetics of midazolam in rats.

J Pharm Pharmacol 2019 Dec 3;71(12):1792-1799. Epub 2019 Oct 3.

Department of Pharmaceutics, Graduate, School of Biomedical Science, Nagasaki University, Nagasaki, Japan.

Objectives: This study aimed to investigate the effects of renal ischaemia/reperfusion (I/R)-induced acute kidney injury (AKI) on the distribution of midazolam (MDZ), a probe drug for cytochrome P450 3A (CYP3A) activity.

Methods: We established an AKI model inducing ischaemia of both renal pedicles for 60 min followed by 24-h reperfusion. MDZ was administered intravenously (i. Read More

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http://dx.doi.org/10.1111/jphp.13167DOI Listing
December 2019
2 Reads

Photopotentiation of the GABA receptor with caged diazepam.

Proc Natl Acad Sci U S A 2019 10 1;116(42):21176-21184. Epub 2019 Oct 1.

Laboratory for Molecular Photonics, Department of Chemistry, University of Miami, Coral Gables, FL 33146;

As the inhibitory γ-aminobutyric acid-ergic (GABAergic) transmission has a pivotal role in the central nervous system (CNS) and defective forms of its synapses are associated with serious neurological disorders, numerous versions of caged GABA and, more recently, photoswitchable ligands have been developed to investigate such transmission. While the complementary nature of these probes is evident, the mechanisms by which the GABA receptors can be photocontrolled have not been fully exploited. In fact, the ultimate need for specificity is critical for the proper synaptic exploration. Read More

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http://dx.doi.org/10.1073/pnas.1902383116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6800354PMC
October 2019

Diazepam enhances melanogenesis, melanocyte dendricity and melanosome transport via the PBR/cAMP/PKA pathway.

Int J Biochem Cell Biol 2019 11 24;116:105620. Epub 2019 Sep 24.

Changzhou Wujin People's Hospital, Changzhou 213000, China.

Diazepam is a medicament of the benzodiazepine family and it typically produces a sedative effect. Researchers have revealed that diazepam can induce melanogenesis and produce dendrite-like structures in B16 melanoma cells. However, the associated mechanisms of melanogenesis and phenotypic alterations have mostly remained unknown. Read More

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http://dx.doi.org/10.1016/j.biocel.2019.105620DOI Listing
November 2019
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Excitatory GABAergic signalling is associated with benzodiazepine resistance in status epilepticus.

Brain 2019 11;142(11):3482-3501

Division of Cell Biology, Department of Human Biology, Neuroscience Institute and Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.

Status epilepticus is defined as a state of unrelenting seizure activity. Generalized convulsive status epilepticus is associated with a rapidly rising mortality rate, and thus constitutes a medical emergency. Benzodiazepines, which act as positive modulators of chloride (Cl-) permeable GABAA receptors, are indicated as first-line treatment, but this is ineffective in many cases. Read More

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http://dx.doi.org/10.1093/brain/awz283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904319PMC
November 2019
1 Read

Clinical Pearls on Sleep Management in Atopic Dermatitis.

Dermatitis 2019 Sep/Oct;30(5):287-293

Division of Dermatology, Department of Medicine, University of Arizona, Tucson.

Multiple etiologies contribute to sleep disturbance in atopic dermatitis (AD) patients, including learned scratching behavior and increased monoamines, cutaneous blood flow, inflammatory cell activities, and cytokines, as well as decreased melatonin, anti-inflammatory cytokines, and skin barrier function. Insomnia impairs cognitive development in children with AD, leading to behavioral problems and learning disabilities. Insomnia in adults with AD impedes work productivity. Read More

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http://dx.doi.org/10.1097/DER.0000000000000523DOI Listing
February 2020
5 Reads

Active Anti-Inflammatory and Hypolipidemic Derivatives of Lorazepam.

Molecules 2019 Sep 9;24(18). Epub 2019 Sep 9.

Department of Pharmaceutical Chemistry, School of Pharmacy, Aristotelian University of Thessaloniki, 54124 Thessaloniki, Greece.

Novel derivatives of some non steroidal anti-inflammatory drugs, as well as of the antioxidants α-lipoic acid, trolox and ()-3-(3,5-di-tert-butyl-4-hydroxyphenyl)acrylic acid with lorazepam were synthesised by a straightforward method at satisfactory to high yields (40%-93%). All the tested derivatives strongly decreased lipidemic indices in rat plasma after Triton induced hyperlipidaemia. They also reduced acute inflammation and a number of them demonstrated lipoxygenase inhibitory activity. Read More

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http://dx.doi.org/10.3390/molecules24183277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767220PMC
September 2019

Intra-accumbal orexin-1 receptor inhibition prevents the anxiolytic-like effect of ethanol and leads to increases in orexin-A content and receptor expression.

Pharmacol Biochem Behav 2019 10 16;185:172761. Epub 2019 Aug 16.

Bases Moleculares de las Adicciones, Subdirección de Investigaciones Clínicas, INPRFM, México D.F., Mexico. Electronic address:

Alcohol use is frequently associated with mood disorders. Similarly, individuals suffering from these disorders have a higher risk of developing alcoholism. Several reports have implicated orexin signaling in different behaviors related to alcohol consumption, whereas antagonists block these actions. Read More

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http://dx.doi.org/10.1016/j.pbb.2019.172761DOI Listing
October 2019
1 Read

Benzodiazepine abuse among athletes: Pain relief or just a weapon against insomnia? A clinical case study.

Scand J Med Sci Sports 2019 Dec 2;29(12):1937-1940. Epub 2019 Sep 2.

Department of Experimental Psychology, Mind, Brain and Behavior Research Center (CIMCYC), University of Granada, Granada, Spain.

It is widely recognized that benzodiazepine abuse can potentially induce addiction. Benzodiazepine addiction among athletes is a new and growing phenomenon that we are encountering among our patients. We describe a case of lormetazepam addiction in a female competitive marathon runner. Read More

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http://dx.doi.org/10.1111/sms.13540DOI Listing
December 2019

Psychotropic effects of -theanine and its clinical properties: From the management of anxiety and stress to a potential use in schizophrenia.

Pharmacol Res 2019 09 11;147:104395. Epub 2019 Aug 11.

School of Medicine, Federal University of Uberlândia (UFU), Uberlandia, Minas Gerais, Brazil. Electronic address:

Anxiety disorders are highly prevalent in modern societies, and are ranked the sixth most important contributor of non-fatal negative health outcomes. -theanine is an amino acid naturally found in green tea (Camellia sinensis) and some other plant extracts, and recent clinical studies have proposed promising adjuvant effects of -theanine for the negative impact of anxiety and psychological stress on health. In this integrative narrative review, we aimed to appraise and further discuss the effects of -theanine administration on anxiety disorders and psychological stress. Read More

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http://dx.doi.org/10.1016/j.phrs.2019.104395DOI Listing
September 2019
1 Read

Initiating opioid agonist treatment for opioid use disorder nationally in the Veterans Health Administration: Who gets what?

Subst Abus 2020 12;41(1):110-120. Epub 2019 Aug 12.

VA New England Mental Illness Research and Education Center, West Haven, Connecticut, USA.

Despite substantial benefits associated with opioid agonist treatment (OAT) with buprenorphine and methadone for opioid use disorder (OUD), only a small proportion of patients with OUD initiate OAT. There is a lack of studies addressing the correlates of OAT initiation among patients with OUD. Using Veterans Health Administration (VHA) national administrative data, we identified veterans with OUD who started OAT with either buprenorphine or methadone maintenance treatment (MMT) in fiscal year (FY) 2012 (first prescription of buprenorphine or first methadone clinic visit after the first 60 days of FY) and those who received no OAT that year. Read More

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http://dx.doi.org/10.1080/08897077.2019.1640831DOI Listing
August 2019
3 Reads

Changes in Prescription of Psychotropic Drugs After Introduction of Polypharmacy Reduction Policy in Japan Based on a Large-Scale Claims Database.

Clin Drug Investig 2019 Nov;39(11):1077-1092

Biometrics and Data Management, Pfizer R&D Japan G.K., Shibuya-ku, Tokyo, Japan.

Background And Objectives: In Japan, polypharmacy reduction policy, which reduces the reimbursement of medical cost, was introduced to address unnecessary psychotropic polypharmacy. The rule was applied to the prescriptions of three or more anxiolytics or three or more hypnotics in the policy introduced in 2012. The prescriptions of four or more antidepressants or four or more antipsychotics were added to the rule in the policy revised in 2014. Read More

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http://dx.doi.org/10.1007/s40261-019-00838-wDOI Listing
November 2019

The Binding Mechanisms and Inhibitory Effect of Intravenous Anesthetics on AChE In Vitro and In Vivo: Kinetic Analysis and Molecular Docking.

Authors:
Mesut Işık

Neurochem Res 2019 Sep 5;44(9):2147-2155. Epub 2019 Aug 5.

Department of Pharmacy Services, Vocational School of Health Services, Harran University, 63000, Şanlıurfa, Turkey.

Inhibitors of acetylcholinesterase (AChE), which have an important role in the prevention of excessive AChE activity and β-amyloid (Aβ) formation are widely used in the symptomatic treatment of Alzheimer's disease (AD). The inhibitory effect of anesthetic agents on AChE was determined by several approaches, including binding mechanisms, molecular docking and kinetic analysis. Inhibitory effect of intravenous anesthetics on AChE as in vitro and in vivo have been discovered. Read More

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http://dx.doi.org/10.1007/s11064-019-02852-yDOI Listing
September 2019

Recurrent stress across life may improve cognitive performance in individual rats, suggesting the induction of resilience.

Transl Psychiatry 2019 08 5;9(1):185. Epub 2019 Aug 5.

Department of Psychiatry and Psychotherapy, Charité University Medicine Berlin, Campus Mitte, Berlin, Germany.

Depressive symptoms are often accompanied by cognitive impairments and recurrent depressive episodes are discussed as a potential risk for dementia. Especially, stressful life events are considered a potent risk factor for depression. Here, we induced recurrent stress-induced depressive episodes over the life span of rats, followed by cognitive assessment in the symptom-free period. Read More

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http://www.nature.com/articles/s41398-019-0523-5
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http://dx.doi.org/10.1038/s41398-019-0523-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683163PMC
August 2019
5 Reads

Diazepam inhibited lipopolysaccharide (LPS)-induced pyroptotic cell death and alleviated pulmonary fibrosis in mice by specifically activating GABA receptor α4-subunit.

Biomed Pharmacother 2019 Oct 24;118:109239. Epub 2019 Jul 24.

Department of Anesthesiology, The Second People's Hospital of Yunnan Province, Qingnian Road, Kunming, Yunnan, China. Electronic address:

Diazepam could regulate immune system and inflammation, which might be a potential therapeutic agent for pulmonary fibrosis in clinic. This study showed that diazepam reversed LPS-induced inhibition of cell proliferation and promotion of cell apoptosis. Of note, LPS specifically induced Caspase-11 dependent cell pyroptosis, which were significantly attenuated by diazepam or pyroptosis inhibitor necrosulfonamide (NSA) treatment. Read More

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http://dx.doi.org/10.1016/j.biopha.2019.109239DOI Listing
October 2019

5-Hydroxytryptophan: A precursor of serotonin influences regional blood-brain barrier breakdown, cerebral blood flow, brain edema formation, and neuropathology.

Int Rev Neurobiol 2019 18;146:1-44. Epub 2019 Jul 18.

International Experimental Central Nervous System Injury & Repair (IECNSIR), Department of Surgical Sciences, Anesthesiology & Intensive Care Medicine, Uppsala University Hospital, Uppsala University, Uppsala, Sweden. Electronic address:

5-Hydroxytryptophan (5-HTP), a precursor of serotonin, is therapeutically used for several psychiatric disorders such as anxiety and depression in the clinic. However, severe side effects, including abnormal mental functions, behavioral disturbances and intolerance are associated with this treatment. 5-HTP-induced elevation of plasma and brain serotonin levels may affect blood-brain barrier (BBB) breakdown, edema formation and regional cerebral blood flow (CBF) disturbances. Read More

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http://dx.doi.org/10.1016/bs.irn.2019.06.005DOI Listing
February 2020
3 Reads

Mechanisms underlying the EEG biomarker in Dup15q syndrome.

Mol Autism 2019 3;10:29. Epub 2019 Jul 3.

2Center for Autism Research and Treatment, University of California Los Angeles, Semel Institute for Neuroscience, Los Angeles, CA 90024 USA.

Background: Duplications of 15q11.2-q13.1 (Dup15q syndrome), including the paternally imprinted gene and three nonimprinted gamma-aminobutyric acid type-A (GABA) receptor genes, are highly penetrant for neurodevelopmental disorders such as autism spectrum disorder (ASD). Read More

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http://dx.doi.org/10.1186/s13229-019-0280-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609401PMC
June 2020
7 Reads

The impact of the Canterbury earthquakes on dispensing for older person's mental health.

Int J Geriatr Psychiatry 2019 11 7;34(11):1599-1604. Epub 2019 Aug 7.

Department of Psychological Medicine, University of Otago, Christchurch, Christchurch, New Zealand.

Objective: To evaluate the impact of the Canterbury earthquakes on the mental health of older people by examining dispensing patterns of psychotropic medication.

Method: Dispensing data from community pharmacies for antidepressants, antipsychotics, anxiolytics, and sedative/hypnotics are routinely recorded in a national database. Longitudinal data are available for residents of the Canterbury District Health Board (DHB) (n = 67 760 at study onset) and the rest of New Zealand (n = 469 055 at study onset). Read More

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http://dx.doi.org/10.1002/gps.5171DOI Listing
November 2019
1 Read

High-dose lormetazepam dependence: strange case of Dr. Jekyll and Mr. Hyde-comment.

Intern Emerg Med 2020 03 8;15(2):341-342. Epub 2019 Jul 8.

Department of Clinical Neurosciences, Neurology, Sleep Disorders Center, IRCCS San Raffaele Scientific Institute, Milan, Italy.

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http://dx.doi.org/10.1007/s11739-019-02142-zDOI Listing
March 2020
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Intranasal Lorazepam for Treatment of Severe Agitation in a Pediatric Behavioral Health Patient in the Emergency Department.

Ann Emerg Med 2020 01 4;75(1):86-89. Epub 2019 Jul 4.

Department of Emergency Medicine, Division of Pediatric Emergency Medicine, Columbia University College of Physicians and Surgeons, New York, NY.

The treatment of severe agitation, aggression, and violent behavior in behavioral health patients who present to the emergency department (ED) often requires the intramuscular administration of a sedative. However, administering an intramuscular sedative to an uncooperative patient is associated with the risk of needlestick injuries to both patients and health care providers, and times to onset of sedation range from 15 to 45 minutes. Intranasal absorption is more rapid than intramuscular, with sedatives such as lorazepam reaching peak serum concentrations up to 6 times faster when administered intranasally. Read More

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http://dx.doi.org/10.1016/j.annemergmed.2019.05.020DOI Listing
January 2020
1 Read

Sensitivity to diazepam after a single session of forced swim stress in weaning Wistar rats.

Acta Pharm 2018 Sep;68(3):381-388

Laboratorio de Neurofarmacología, Instituto de Neuroetología, Universidad Veracruzana, Xalapa, México.

The present study investigated the sensitivity to stress and diazepam in weaning (21-day old) Wistar rats. A single 15-min session of forced swimming was used to induce anxiety-like behavior. The group that was forced to swim exhibited an increase in anxiety-like behavior in the elevated plus maze (EPM) and open field test (OFT) compared to the non-stressed group. Read More

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http://dx.doi.org/10.2478/acph-2018-0027DOI Listing
September 2018
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Propofol Compared to Midazolam Sedation and to General Anesthesia for Percutaneous Microwave Ablation in Patients with Hepatic Malignancies: A Single-Center Comparative Analysis of Three Historical Cohorts.

Cardiovasc Intervent Radiol 2019 Nov 26;42(11):1597-1608. Epub 2019 Jun 26.

Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers - location VUmc, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.

Purpose: In percutaneous ablation procedures, periprocedural pain, unrest and respiratory concerns can be detrimental to achieve a safe and efficacious ablation and impair treatment outcome. This study aimed to compare the association between anesthetic technique and local disease control in patients undergoing percutaneous microwave ablation (MWA) of colorectal liver metastases (CRLM) and hepatocellular carcinoma (HCC).

Materials And Methods: This IRB-exempted single-center comparative, retrospective analysis of three cohorts analyzed 90 patients treated for hepatic malignancies from January 2013 until September 2018. Read More

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http://dx.doi.org/10.1007/s00270-019-02273-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6775535PMC
November 2019
8 Reads

[A case of post-cardiac arrest syndrome presenting with lateralized periodic discharges evolving to a cyclic seizure pattern on electroencephalogram].

Rinsho Shinkeigaku 2019 Jul 27;59(7):412-417. Epub 2019 Jun 27.

Department of Internal Medicine, Otemachi Hospital.

A 53-year-old man with hypertension experienced sudden cardiopulmonary arrest. Ambulance crews detected ventricular fibrillation that responded to defibrillation. Cardiopulmonary resuscitation resulted in return of spontaneous circulation (ROSC) after 30 minutes. Read More

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http://dx.doi.org/10.5692/clinicalneurol.cn-001183DOI Listing
July 2019
4 Reads

A Single Ketamine Infusion Combined With Mindfulness-Based Behavioral Modification to Treat Cocaine Dependence: A Randomized Clinical Trial.

Am J Psychiatry 2019 11 24;176(11):923-930. Epub 2019 Jun 24.

New York State Psychiatric Institute, Columbia University Medical Center, New York (Dakwar, Nunes, Hart, Foltin, Carpenter, Levin); the Department of Psychology, Columbia University, New York (Hart); the Department of Psychiatry, Baylor College of Medicine, Houston (Mathew); New York State Psychiatric Institute, Division of Biostatistics, New York (Choi, Basaraba); and the Department of Biostatistics, Columbia University Medical Center, New York (Pavlicova).

Objective: Research has suggested that subanesthetic doses of ketamine may work to improve cocaine-related vulnerabilities and facilitate efforts at behavioral modification. The purpose of this trial was to test whether a single ketamine infusion improved treatment outcomes in cocaine-dependent adults engaged in mindfulness-based relapse prevention.

Methods: Fifty-five cocaine-dependent individuals were randomly assigned to receive a 40-minute intravenous infusion of ketamine (0. Read More

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http://ajp.psychiatryonline.org/doi/10.1176/appi.ajp.2019.18
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http://dx.doi.org/10.1176/appi.ajp.2019.18101123DOI Listing
November 2019
18 Reads

Secukinumab Treatment Does Not Alter the Pharmacokinetics of the Cytochrome P450 3A4 Substrate Midazolam in Patients With Moderate to Severe Psoriasis.

Clin Pharmacol Ther 2019 12 3;106(6):1380-1388. Epub 2019 Aug 3.

Novartis Institutes for BioMedical Research, Basel, Switzerland.

This open-label disease-drug-drug interaction study assessed whether blockade of the interleukin (IL)-17A pathway by secukinumab and subsequent downregulation of inflammatory cytokines like IL-6 or high-sensitivity C-reactive protein affects the pharmacokinetics (PKs) of a sensitive probe substrate of the cytochrome P450 3A4 isoform (CYP3A4). The PKs of midazolam, metabolized by CYP3A4, was evaluated before and after 7 and 35 days of treatment initiation of subcutaneous secukinumab at a dose of 300 mg weekly in 24 patients with moderate-to-severe psoriasis. Although demonstrating the expected decrease in downstream inflammatory cytokines, secukinumab had no clinically relevant effects on the PKs of midazolam, provided substantial clinical benefit, and was generally well tolerated. Read More

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http://dx.doi.org/10.1002/cpt.1558DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6896234PMC
December 2019
4 Reads
7.903 Impact Factor