80,447 results match your criteria Secondary Lung Tumors

Sarcoma of unknown primary: myth or reality?

J Egypt Natl Canc Inst 2022 Jun 27;34(1):27. Epub 2022 Jun 27.

University of Ioannina, Ioannina, Greece.

Background: Sarcoma of unknown primary (SUP) designates an enigmatic entity with histologic confirmation of a metastatic tumor without an identifiable primary after a thorough diagnostic workup. The term "unknown primary" is heavily debatable given that sarcomas can arise from any tissue that harbors its histological structure. In this review, we discuss the validity of SUP as a distinct entity. Read More

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Establishment of Thoracic Surgical Difficulty Assessment Scale based on Delphi method.

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2022 May;47(5):655-664

Department of Thoracic Surgery, Second Xiangya Hospital, Central South University, Changsha 410011, China.

Objectives: The difficulty of surgery, which is related to surgical safety, has only been mentioned as a subjective perception for a long time. There are few studies to quantitatively and systematically evaluate the difficulty of thoracic surgery. This study aims to establish a quantitative evaluation index system for thoracic surgical difficulty, and to evaluate its reliability and validity. Read More

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Atypical presentation of a rare gestational trophoblastic neoplasm: A case report.

J Pak Med Assoc 2022 Jun;72(6):1260-1262

Department of Surgery, Aga Khan University, Karachi, Pakistan.

A 34-year-old woman had a history of 3 miscarriages and presented with symptoms of an unproductive cough and rising serum beta-human chorionic gonadotropin (b-hCG) levels. There were no gynaecological symptoms. A diagnosis of Choriocarcinoma with pulmonary metastasis was made. Read More

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Role of biomarkers in lung nodule evaluation.

Curr Opin Pulm Med 2022 Jul;28(4):275-281

Cleveland Clinic, Cleveland, Ohio, USA.

Purpose Of Review: Worldwide, lung cancer is the leading cause of cancer mortality. Much of this mortality is thought to be secondary to detection in later stages, where treatment options and survivability are limited. The goals of lung nodule evaluation are to expedite the diagnosis and treatment of patients with malignant nodules and to minimize unnecessary diagnostic procedures in those with benign nodules. Read More

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Chaperonin containing TCP1 as a marker for identification of circulating tumor cells in blood.

PLoS One 2022 24;17(6):e0264651. Epub 2022 Jun 24.

Burnett School of Biomedical Science, College of Medicine, University of Central Florida, Orlando, Florida, United States of America.

Herein we report the use of Chaperonin-Containing TCP-1 (CCT or TRiC) as a marker to detect circulating tumor cells (CTCs) that are shed from tumors during oncogenesis. Most detection methods used in liquid biopsy approaches for enumeration of CTCs from blood, employ epithelial markers like cytokeratin (CK). However, such markers provide little information on the potential of these shed tumor cells, which are normally short-lived, to seed metastatic sites. Read More

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Harnessing anti-cytomegalovirus immunity for local immunotherapy against solid tumors.

Proc Natl Acad Sci U S A 2022 Jun 24;119(26):e2116738119. Epub 2022 Jun 24.

Laboratory of Cellular Oncology, National Cancer Institute, NIH, Bethesda, MD 20892.

Tumor infiltration by T cells profoundly affects cancer progression and responses to immunotherapy. However, the tumor immunosuppressive microenvironment can impair the induction, trafficking, and local activity of antitumor T cells. Here, we investigated whether intratumoral injection of virus-derived peptide epitopes could activate preexisting antiviral T cell responses locally and promote antitumor responses or antigen spreading. Read More

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Neurofibromatosis from Head to Toe: What the Radiologist Needs to Know.

Radiographics 2022 Jun 24:210235. Epub 2022 Jun 24.

From the Department of Radiology (M.X.W., C.T.J., K.M.E.) and Department of Lymphoma and Myeloma (S.K.), University of Texas MD Anderson Cancer Center, Pickens Academic Tower, 1400 Pressler St, Houston, TX 77030-4009; Department of Radiology, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio (J.R.D.); Department of Radiology, Stanford University, Stanford, Calif (J.G.); Department of Radiology (A.H.) and Faculty of Medicine (M.M.), Alexandria University, Alexandria, Egypt; and Department of Radiology, Mayo Clinic Arizona, Phoenix/Scottsdale, Ariz (P.M.P.).

Neurofibromatosis type 1 (NF1) and neurofibromatosis type 2 (NF2) are autosomal dominant inherited neurocutaneous disorders or phakomatoses secondary to mutations in the and tumor suppressor genes, respectively. Although they share a common name, NF1 and NF2 are distinct disorders with a wide range of multisystem manifestations that include benign and malignant tumors. Imaging plays an essential role in diagnosis, surveillance, and management of individuals with NF1 and NF2. Read More

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Interventional oncology procedures for breast cancer metastatic disease: current role and clinical applications.

Diagn Interv Radiol 2022 May;28(3):249-256

2nd Department of Radiology, University General Hospital "Attikon", Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Worldwide, breast cancer constitutes the most common malignant neoplasm among females, impacting 2.1 million women annually. Interventional oncology techniques have been recently added as an additional therapeutic and palliative alternative in breast cancer metastatic disease, concerning mainly osseous, liver, and lung metastasis. Read More

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Bone Metastasis and Immune Checkpoint Inhibitors in Non-Small Cell Lung Cancer (NSCLC): Microenvironment and Possible Clinical Implications.

Int J Mol Sci 2022 Jun 20;23(12). Epub 2022 Jun 20.

Dipartimento di Oncologia Medica, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, 33081 Aviano, Italy.

Patients with non-small cell lung cancer (NSCLC) develop bone metastasis (BoM) in more than 50% of cases during the course of the disease. This metastatic site can lead to the development of skeletal related events (SREs), such as severe pain, pathological fractures, spinal compression, and hypercalcemia, which reduce the patient's quality of life. Recently, the treatment of advanced NSCLC has radically changed due to the advent of immunotherapy. Read More

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Intraperitoneal paclitaxel for patients with primary malignant peritoneal mesothelioma: a phase I/II dose escalation and safety study-INTERACT MESO.

BMJ Open 2022 Jun 22;12(6):e062907. Epub 2022 Jun 22.

Department of Surgical Oncology, Erasmus MC Kanker Instituut, Rotterdam, The Netherlands.

Introduction: Malignant peritoneal mesothelioma (MPM) is a rare, aggressive tumour arising primarily from the peritoneum. The only potentially curative treatment is cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC). However, the majority of patients are not eligible to undergo this treatment. Read More

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BCG hydrogel promotes CTSS-mediated antigen processing and presentation, thereby suppressing metastasis and prolonging survival in melanoma.

J Immunother Cancer 2022 Jun;10(6)

Experimental Pathology, University of Bern Institute of Pathology, Bern, Switzerland

Background: The use of intralesional BCG (intralesional live BCG) for the treatment of metastatic melanoma resulted in regression of directly injected, and occasionally of distal lesions. However, intralesional-BCG is less effective in patients with visceral metastases and did not significantly improve overall survival.

Methods: We generated a novel BCG lysate and developed it into a thermosensitive PLGA-PEG-PLGA hydrogel (BCG hydrogel), which was injected adjacent to the tumor to assess its antitumor effect in syngeneic tumor models (B16F10, MC38). Read More

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Endosonography and endosonography guided needle aspiration for left adrenal gland assessment in lung cancer patients - 10 years' experience.

Adv Respir Med 2022 ;90(3):157-163

Endoscopy Unit, Pulmonary Hospital, Zakopane, Poland.

Introduction: Lung cancer patients (LCP) require invasive evaluation of left adrenal glands (LAG) if distant metastases (M1b/1c) are suspected in CT or PET-CT. Only few studies showed utility of endosonography and particularly EUS-b-FNA as minimally invasive endoscopic method of LAG analysis.

Material And Methods: A retrospective study of consecutive LCP was conducted in two pulmonology centers between January 2010 and December 2019. Read More

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A Direct Comparative Study of Bronchoscopic Navigation Planning Platforms for Peripheral Lung Navigation: The ATLAS Study.

J Bronchology Interv Pulmonol 2022 Jul 9;29(3):171-178. Epub 2021 Sep 9.

Division of Pulmonary and Critical Care, Johns Hopkins University School of Medicine, Baltimore, MD.

Background: The use of mapping to guide peripheral lung navigation (PLN) represents an advance in the management of peripheral pulmonary lesions (PPL). Software has been developed to virtually reconstruct computed tomography images into 3-dimensional airway maps and generate navigation pathways to target PPL. Despite this there remain significant gaps in understanding the factors associated with navigation success and failure including the cartographic performance characteristics of these software algorithms. Read More

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The clinicopathological and prognostic value of CXCR4 expression in patients with lung cancer: a meta-analysis.

BMC Cancer 2022 Jun 21;22(1):681. Epub 2022 Jun 21.

Department of Pulmonary and Critical Care Medicine, Ningbo Medical Center Lihuili Hospital, 1111 Jiangnan Road, Zhejiang, 315000, China.

Background: The C-X-C chemokine receptor 4 (CXCR4) has been suggested to play an important role in several types of cancers and is related to biological behaviors connected with tumor progression. However, the clinical significance and application of CXCR4 in lung cancer remain disputable. Thus, we conducted a meta-analysis to investigate the impact of CXCR4 expression on survival and clinicopathological features in lung cancer. Read More

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Preoperative PDW levels predict pulmonary metastasis in patients with hepatocellular carcinoma.

BMC Cancer 2022 Jun 21;22(1):683. Epub 2022 Jun 21.

Department of Internal Medicine, Harbin Medical University Cancer Hospital, Harbin Medical University, Harbin, Heilongjiang, 150081, China.

Background: In hepatocellular carcinoma (HCC), pulmonary metastasis (PM) after hepatectomy is associated with poor clinical outcomes. The crucial phases of tumour cell proliferation, angiogenesis, and metastasis all entail platelet activation. In HCC, platelet distribution width (PDW) suggests platelet size changes and predicts a worse prognosis. Read More

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A novel carbon-fibre adjustable reusable accessory (CARA) for supine breast positioning to reduce toxicity in breast adjuvant radiotherapy: a study protocol for a multicentre phase III randomized controlled trial.

BMC Cancer 2022 Jun 20;22(1):673. Epub 2022 Jun 20.

Department of Surgery, Division of Radiation Oncology and Developmental Radiotherapeutics, University of British Columbia, Vancouver, BC, Canada.

Background: A novel device for supine positioning in breast radiotherapy for patients with large or pendulous breasts has been developed and tested in phase II studies. This trial is designed to assess the efficacy of the device to reduce skin toxicity and unwanted normal tissue dose in comparison to the current clinical standard for supine breast support during breast radiotherapy.

Methods: Patients at high risk for moist desquamation, having infra-mammary fold or lateral ptosis, will be randomized into two arms. Read More

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Lung Adenocarcinoma Metastasis to the Vocal Cord.

Ear Nose Throat J 2022 Jun 20:1455613221107689. Epub 2022 Jun 20.

Department of Otolaryngology-Head and Neck Surgery, 65722Chonnam National University Medical School & Chonnam National University Hwasun Hospital, Hwasun, Korea.

Metastases to the vocal cord from a distant organ are extremely rare. This case showed metastatic adenocarcinoma on the vocal cord of lung origin in a 75-year-old nonsmoking female with a history of lung adenocarcinoma surgery 2 years earlier. The vocal cord mass was surgically removed, and the biopsy confirmed metastatic adenocarcinoma of lung origin with thyroid transcription factor (TTF)-1 positivity. Read More

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Does the Combined Use of Aspirin and Immunotherapy Result in Better Outcomes in Non-Small Cell Lung Cancer Than Immunotherapy Alone?

Cureus 2022 Jun 13;14(6):e25891. Epub 2022 Jun 13.

Hematology and Medical Oncology, St. Luke's University Health Network, Bethlehem, USA.

Introduction:  Immunotherapy works by stimulating the immune system against cancer cells. Resistance to immunotherapy represents a significant challenge in the field of medical oncology. The mechanisms by which cancer cells evade immunotherapy are not well understood. Read More

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Abduction Deficit Mimicking Sixth Nerve Palsy due to Metastasis in Systemic Malignancy: Rare Case Report.

Middle East Afr J Ophthalmol 2021 Oct-Dec;28(4):263-266. Epub 2022 Apr 30.

Department of Ophthalmology, AIIMS, Bhubaneswar, Odisha, India.

Lateral rectus palsy presenting as abduction deficit resulting in diplopia is attributed to neurogenic causes. Metastasis as a cause of sixth cranial palsy is an extremely rare entity but cannot be overlooked. Cases of metastasis to lateral rectus secondary to lung and breast carcinoma have been reported. Read More

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Phase 1, dose-escalation study of guadecitabine (SGI-110) in combination with pembrolizumab in patients with solid tumors.

J Immunother Cancer 2022 Jun;10(6)

Cancer Biomarkers Team, Institute of Cancer Research, Sutton, UK.

Background: Data suggest that immunomodulation induced by DNA hypomethylating agents can sensitize tumors to immune checkpoint inhibitors. We conducted a phase 1 dose-escalation trial (NCT02998567) of guadecitabine and pembrolizumab in patients with advanced solid tumors. We hypothesized that guadecitabine will overcome pembrolizumab resistance. Read More

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Length of stay and cost of care associated with admissions for atrial fibrillation among patients with cancer.

BMC Cardiovasc Disord 2022 Jun 17;22(1):272. Epub 2022 Jun 17.

Section of Cardiac Electrophysiology, Division of Cardiovascular Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Background: The aim of this study is to assess the burden of AF-related hospitalizations inclusive of inflation-adjusted cost-of-care and length-of-stay (LOS) among cancer patients and the impact of direct current cardioversion (DCCV) on these outcomes.

Methods: Using the National Inpatient Sample (NIS), patients hospitalized with either a primary or secondary diagnosis of AF and comorbid cancer were identified and both cost of hospitalization and LOS were evaluated for each group. Subgroup analyses were performed for specific cancer types (breast, lung, colon, prostate and lymphoma), and those receiving DCCV. Read More

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Circulating tumor cell assay to non-invasively evaluate PD-L1 and other therapeutic targets in multiple cancers.

PLoS One 2022 17;17(6):e0270139. Epub 2022 Jun 17.

Department of Research and Innovation, Datar Cancer Genetics, Nasik, Maharashtra, India.

Biomarker directed selection of targeted anti-neoplastic agents such as immune checkpoint inhibitors, small molecule inhibitors and monoclonal antibodies form an important aspect of cancer treatment. Immunohistochemistry (IHC) analysis of the tumor tissue is the method of choice to evaluate the presence of these biomarkers. However, a significant barrier to biomarker testing on tissue is the availability of an adequate amount of tissue and need for repetitive sampling due to tumor evolution. Read More

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Incidence and risk factors for the development of cerebral metastasis in cervical cancer patients.

J Gynecol Oncol 2022 Jun 8. Epub 2022 Jun 8.

Federal University of Rio de Janeiro State (UNIRIO), Rio de Janeiro, Brazil.

Objective: Cerebral metastasis (CM) in cervical cancer (CC) cases, although rare, results in high lethality rates. The present study aimed to assess CM incidence in a Brazilian reference CC center and evaluate the risk factors for CM development. Retrospective observational study of patients diagnosed with CC between 2010 and 2017. Read More

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Two Novel Nomograms Predicting the Risk and Prognosis of Pancreatic Cancer Patients With Lung Metastases: A Population-Based Study.

Front Public Health 2022 31;10:884349. Epub 2022 May 31.

Department of Orthopedics, Zhejiang Provincial People's Hospital, Hangzhou, China.

Background: Pancreatic cancer (PC) is one of the most common malignant types of cancer, with the lung being the frequent distant metastatic site. Currently, no population-based studies have been done on the risk and prognosis of pancreatic cancer with lung metastases (PCLM). As a result, we intend to create two novel nomograms to predict the risk and prognosis of PCLM. Read More

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Identification of Small Nucleolar RNA SNORD60 as a Potential Biomarker and Its Clinical Significance in Lung Adenocarcinoma.

Biomed Res Int 2022 7;2022:5501171. Epub 2022 Jun 7.

Chinese PLA Medical School, Beijing 100853, China.

Non-small-cell lung cancer (NSCLC) is the leading cause of cancer deaths in the world and often diagnosed at an advanced stage, so it is urgent to explore the pathogenesis and new diagnostic biomarkers. Accumulated evidences suggested that small nucleolar RNAs (snoRNAs) played a key role in the development and progression of NSCLC. To examine differential expression snoRNA profile and identify snoRNAs with clinical significance in lung adenocarcinoma (LUAD), The Cancer Genome Atlas (TCGA) LUAD RNA sequencing dataset was used to investigate differential expression snoRNA signatures and compared with snoRNA PCR array analysis in pair-matched LUAD tissues. Read More

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Pembrolizumab Induced Acute Kidney Injury and Liver Injury in a Patient with Malignant Melanoma.

S D Med 2022 Apr;75(4):162-165

Division of Transplant Hepatology, University of South Dakota Sanford School of Medicine.

Immune checkpoint inhibitors (ICIs) have recently gained recognition as valuable treatment options for a variety of cancers. Pembrolizumab is a monoclonal antibody that acts as an inhibitor of programmed cell death receptor-1 (PD-1). This helps release host T-cells from regulatory inhibition by tumor neoantigens, therefore mediating antitumor effects. Read More

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A comparative analysis of thermal ablation techniques in the treatment of primary and secondary lung tumors: a single-center experience.

Radiol Med 2022 Jun 14. Epub 2022 Jun 14.

Departmental Faculty of Medicine and Surgery, Unit of Interventional Radiology, Campus Bio-Medico University of Rome, Via Alvaro del Portillo, 21, 00128, Rome, Italy.

Purpose: To evaluate efficacy and safety of radiofrequency ablation (RFA) and microwave ablation (MWA) in unresectable lung malignancies.

Methods: Data regarding patients with primary and secondary lung tumors treated with RFA or MWA from 2008 to 2020 were reviewed retrospectively. Primary study objectives such as technical success, primary and secondary technique efficacy rates, local tumor progression (LTP) rate, LPT-free survival (LPTFS) and overall survival (OS) were assessed. Read More

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Patient navigation to address sociolegal barriers for patients with cancer: A comparative-effectiveness study.

Cancer 2022 Jul;128 Suppl 13:2623-2635

Medical-Legal Partnership, Boston (MLPB), Boston, Massachusetts.

Background: Sociolegal barriers to cancer care are defined as health-related social needs like affordable healthy housing, stable utility service, and food security that may be remedied by public policy, law, regulation, or programming. Legal support has not been studied in cancer care.

Methods: The authors conducted a randomized controlled trial of patients who had newly diagnosed cancer at a safety-net medical center in Boston from 2014 through 2017, comparing standard patient navigation versus enhanced navigation partnered with legal advocates to identify and address sociolegal barriers. Read More

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Atypical Metastasis of Lung Adenocarcinoma.

Arch Bronconeumol 2021 10;57(10):650

Department of Gastroenterology, Centro Hospitalar Tondela-Viseu, Viseu, Portugal.

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October 2021

Clinical efficacy of osimertinib in EGFR-mutant non-small cell lung cancer with distant metastasis.

BMC Cancer 2022 Jun 14;22(1):654. Epub 2022 Jun 14.

Department of Respiratory Medicine, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan.

Background: Osimertinib-the third-generation epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI)-has been widely used as a first-line treatment for patients with metastatic EGFR-mutant non-small cell lung cancer (NSCLC). Osimertinib demonstrated central nervous system activity in patients with brain metastasis; however, its efficacy against other distant metastatic organs, including bone and liver, remains unclear. Therefore, we retrospectively analyzed the clinical efficacy of osimertinib in these patients in comparison to other EGFR-TKIs. Read More

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