68,856 results match your criteria Secondary Lung Tumors


Computer-assisted detection of metastatic lung tumors on computed tomography.

Asian Cardiovasc Thorac Ann 2019 Mar;27(3):199-207

5 Department of Thoracic Surgery, The University of Tokyo Hospital, Tokyo, Japan.

Background: This retrospective study examined the performance of computer-assisted detection in the identification of pulmonary metastases.

Methods: Fifty-five patients (41.8% male) who underwent surgery for metastatic lung tumors in our hospital from 2005 to 2012 were included. Read More

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http://dx.doi.org/10.1177/0218492319831836DOI Listing

Primary non-gestational uterine choriocarcinoma mimicking leiomyoma.

Pathol Int 2019 Feb 18. Epub 2019 Feb 18.

Department of Gynecologic Oncology, Kawasaki Medical School, Kurashiki, Okayama, Japan.

Uterine choriocarcinoma is a trophoblastic neoplasm that is most commonly gestational but can also be non-gestational in origin. However, primary non-gestational uterine choriocarcinoma is very rare, with only few cases having been reported. We report a case of a premenopausal woman who had initially been diagnosed with myoma delivery but who was discovered to have primary non-gestational uterine choriocarcinoma. Read More

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http://dx.doi.org/10.1111/pin.12763DOI Listing
February 2019

Effect of Coexisting KRAS and TP53 Mutations in Patients Treated With Chemotherapy for Non-small-cell Lung Cancer.

Clin Lung Cancer 2018 Dec 19. Epub 2018 Dec 19.

Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network and Department of Medicine, University of Toronto, Toronto, ON, Canada.

Background: KRAS and TP53 are common mutations in non-small-cell lung cancer (NSCLC). The Lung Adjuvant Cisplatin Evaluation Biological Program group found adjuvant chemotherapy to be deleterious in patients with coexisting KRAS/TP53 mutations.

Patients And Methods: To validate these results, patients with NSCLC tested for KRAS and TP53 mutations and receiving chemotherapy for any stage NSCLC were selected. Read More

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http://dx.doi.org/10.1016/j.cllc.2018.12.009DOI Listing
December 2018
1 Read

Spontaneous pneumothorax in the elderly: a sign of a malignancy?

Asian Cardiovasc Thorac Ann 2019 Feb 12:218492319831840. Epub 2019 Feb 12.

2 Thoracic Surgery Clinic, University of Health Sciences, Sureyyapasa Training and Research Hospital, Istanbul, Turkey.

Background: Spontaneous pneumothorax usually occurs as a result of rupture of a subpleural bleb or emphysematous bulla. Spontaneous pneumothorax, which is more common in younger age groups, might be the first sign of pulmonary malignancy, especially when it manifests in older patients.

Methods: Data of all patients who were treated for spontaneous pneumothorax in our clinic between June 2013 and June 2017 were examined retrospectively. Read More

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http://dx.doi.org/10.1177/0218492319831840DOI Listing
February 2019
1 Read

Metastatic tumors in the pancreas: the role of endoscopic ultrasound-guided fine-needle aspiration.

Rev Esp Enferm Dig 2019 Feb 11. Epub 2019 Feb 11.

Aparato Digestivo, Clínica Universidad de Navarra.

Background And Objectives: there are few published data on the use of EUS guided fine-needle aspiration in secondary pancreatic lesions. We describe the largest series published so far in a European country.

Patients And Methods: a retrospective review of the cases identified in our institution from 2004 to 2016 has been recorded. Read More

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http://dx.doi.org/10.17235/reed.2019.5914/2018DOI Listing
February 2019
1 Read

Acromegaly associated with GIST, non-small cell lung cancer, clear cell renal cancer, myeloma multiplex, medulla oblongata tumor, adrenal adenoma and follicular thyroid nodules.

Endokrynol Pol 2019 Feb 11. Epub 2019 Feb 11.

Dept. of Endocrinology, Diabetes and Isotope Therapy, Medical University Wroclaw, Pasteura 4, 50-367 Wrocłąw, Poland.

Background: Acromegaly is associated with increased growth hormone (GH) and insulin-like growth factor-I (IGF-I) secretion which may support tumor development and growth.

Case Presentation: A 68-year old woman was diagnosed with acromegaly due to typical clinical and hormonal characteristics. While a contrast-enhanced MRI at diagnosis did not reveal a pituitary adenoma, a 5 mm lesion was identified on repeat scanning 13 months later. Read More

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http://dx.doi.org/10.5603/EP.a2019.0005DOI Listing
February 2019
5 Reads

Anaplastic Lymphoma Kinase (ALK)-positive Tumors: Clinical, Radiographic and Molecular Profiles, and Uncommon Sites of Metastases in Patients With Lung Adenocarcinoma.

Am J Clin Oncol 2019 Feb 5. Epub 2019 Feb 5.

Department of Medical Oncology and Therapeutic Research, City of Hope National Medical Center, Duarte, CA.

Introduction: Anaplastic lymphoma kinase (ALK) gene rearrangements are observed in about 4% to 8% non-small cell lung cancer (NSCLC). ALK+ tumors have been associated with increased pleural and pericardial disease. Our primary objective was to determine the uncommon sites of metastasis of ALK+ NSCLC. Read More

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http://dx.doi.org/10.1097/COC.0000000000000508DOI Listing
February 2019
1 Read

Follicular thyroid carcinoma metastatic to skin: a small papule and a big diagnostic change.

An Bras Dermatol 2019 Jan-Feb;94(1):76-78

Department of Pathology, Laboratório Bacchi, Botucatu (SP), Brazil.

Cutaneous metastases are uncommon in daily practice, although very important, since they may be the first manifestation of an undiscovered primary neoplasm or the first indication of recurrence. Cutaneous metastases from the breast are the most frequent in women and cutaneous metastases from the lung are the most frequent in men. Thyroid carcinoma, despite representing the most frequent endocrine neoplasm, is considered a rare neoplasm, corresponding to 1% of malignant neoplasms diagnosed. Read More

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http://dx.doi.org/10.1590/abd1806-4841.20198299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360978PMC
March 2018
6 Reads

Fit for Cancer Treatment: a prospective feasibility study of primary care initiated prehabilitation for patients with suspected cancer.

BJGP Open 2018 Dec 17;2(4):bjgpopen18X101608. Epub 2018 Oct 17.

Consultant Surgeon and Head of Specialty School Surgery, Wales Post Graduate Medical and Dental Education Deanery School of Surgery, Cardiff University, Cardiff, UK.

Background: Risk profile assessment and corrective interventions using optimisation of health status and prehabilitation represent an important strategy in the management of patients with a suspected cancer diagnosis.

Aim: To determine the feasibility of pre-treatment optimisation and prehabilitation commenced at index primary care consultation, to improve patients' preparation for treatment by maximising the time available.

Design & Setting: Between January 2015 and May 2016, 195 patients presenting to 12 GP practices were deemed eligible to enter the study, of which 189 (96. Read More

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http://dx.doi.org/10.3399/bjgpopen18X101608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348330PMC
December 2018
2 Reads

Nuclear receptor ligands induce TREM-1 expression on dendritic cells: analysis of their role in tumors.

Oncoimmunology 2019 13;8(3):1554967. Epub 2018 Dec 13.

Immuno-Biotherapy of Melanoma and Solid Tumors Unit, Division of Experimental Oncology, IRCCS Scientific Institute San Raffaele, Milan, Italy.

Dendritic cells (DCs) initiate adaptive immune responses after their migration to secondary lymphoid organs. The LXR ligands/oxysterols and the RXR ligand 9-cis Retinoic Acid (9-cis RA) were shown to dampen DC migration to lymphoid organs through the inhibition of CCR7 expression. We performed transcriptomics of DCs undergoing maturation in the presence of the LXR ligand 22R-Hydroxycholesterol (22R-HC). Read More

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https://www.tandfonline.com/doi/full/10.1080/2162402X.2018.1
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http://dx.doi.org/10.1080/2162402X.2018.1554967DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350683PMC
December 2018
2 Reads

Solitary renal metastasis from squamous cell carcinoma of the lung: A case report.

Medicine (Baltimore) 2019 Feb;98(5):e14310

Department of Lung Cancer Center, Cancer Center of West China Hospital.

Rationale: Non-small cell cancer with isolated unilateral renal metastasis is rare, and the role of radical nephrectomy has not been determined. In the present study, a case of a patient with solitary kidney metastasis from squamous cell lung cancer who underwent radical nephrectomy is reported.

Patient Concerns: A 74-year-old patient diagnosed with pulmonary squamous cell lung cancer who had undergone radical pulmonary lobectomy and mediastinal lymph node dissection revealed a solitary mass in the right kidney during the follow-up. Read More

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http://dx.doi.org/10.1097/MD.0000000000014310DOI Listing
February 2019
1 Read
5.723 Impact Factor

Hepatoid Variant of Yolk Sac Tumor of Both Ovaries with Widespread Intraabdominal and Lung Metastasis: A Case Report.

Iran J Pathol 2018 17;13(2):289-293. Epub 2018 Jul 17.

Dept. of Obstetrics and Gynaecology, Melaka Manipal Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India.

Hepatoid variant of yolk sac tumor of ovary is an unusual tumor with an aggressive behavior. It is usually observed in young females, presents with abdominal complaints and is associated with raised α-fetoprotein (AFP) levels. It should be differentiated from other hepatoid tumors involving the ovary. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339500PMC
July 2018
1 Read

Differentiating intrapulmonary metastases from different primary tumors via quantitative dual-energy CT based iodine concentration and conventional CT attenuation.

Eur J Radiol 2019 Feb 14;111:6-13. Epub 2018 Dec 14.

Department of Diagnostic and Interventional Radiology, Klinikum rechts der Isar, Technical University of Munich, Germany.

Introduction: To investigate the utility of quantitative dual-energy spectral CT derived iodine concentration (IC), in comparison with conventional CT attenuation, for the differentiation of pulmonary metastases from different primary malignancies.

Materials And Methods: CT scans were performed on a dual-layer spectral CT. We retrospectively evaluated pulmonary metastases of 130 patients (77 men and 53 women, mean age 63, range 22-87) with primary bone (OS) (osteosarcoma; n = 6), breast (invasive-ductal adenocarcinoma; n = 17), colorectal (CRC) (adenocarcinoma; n = 27), head and neck (HNC) (squamous cell carcinoma; n = 17), kidney (RCC) (clear-cell renal cell carcinoma; n = 10), lung (adenocarcinoma; n = 12), pancreato-biliary (PBC) (adenocarcinoma; n = 18), prostate (adenocarcinoma; n = 5), soft tissue (undifferentiated pleomorphic sarcoma; n = 6), skin (malignant melanoma; n = 6), and urinary tract (transitional-cell carcinoma; n = 6) malignancies. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0720048X183045
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http://dx.doi.org/10.1016/j.ejrad.2018.12.015DOI Listing
February 2019
6 Reads

Combining 3D sidewall electrodes and contraction/expansion microstructures in microchip promotes isolation of cancer cells from red blood cells.

Talanta 2019 May 26;196:546-555. Epub 2018 Dec 26.

National Engineering Research Center for Tissue Restoration and Reconstruction (NERC-TRR), Guangzhou 510006, China; School of Material Science and Engineering, South China University of Technology, Guangzhou 510006, China; School of Biomedical Science and Engineering, South China University of Technology, Guangzhou 510006, China. Electronic address:

Cell sorting from heterogeneous organisms and tissues composed of multi-type cells is of great importance in biological and clinical applications. As promising cell sorting methods, dielectrophoresis (DEP) and hydrodynamics are attracting much attention in recent years. In this paper, we report a novel strategy by coupling DEP unit (3D sidewall electrodes) and hydrodynamic unit (microchannels with contraction/expansion structures) together in one microfluidic chip. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00399140183132
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http://dx.doi.org/10.1016/j.talanta.2018.12.059DOI Listing
May 2019
4 Reads

A case report of primary osteosarcoma originating from kidney.

Medicine (Baltimore) 2019 Jan;98(4):e14234

Department of Urology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.

Rationale: Primary osteosarcoma of the kidney is a very rare subtype of renal neoplasms. There are only 27 cases reported in the literature since 1936. In addition, it has a high risk of metastasis and very low survival rate. Read More

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http://dx.doi.org/10.1097/MD.0000000000014234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358323PMC
January 2019
2 Reads

Significant response of low-dose apatinib monotherapy in brain metastases of triple-negative breast cancer: A case report.

Medicine (Baltimore) 2019 Jan;98(4):e14182

Department of Oncology, The Second People's Hospital of Yibin, Yibin, Sichuan, P. R. China.

Rationale: The potential efficacy of apatinib in patients with advanced triple-negative breast cancer (TNBC) has been observed in a previous phase II clinical study. However, there is no study to evaluate its efficacy and safety in TNBC patients with brain metastasis (BM). Here we report one case that apatinib exhibited excellent antitumor effects in a breast cancer patient with brain metastasis, with no serious treatment-associated with adverse event. Read More

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http://dx.doi.org/10.1097/MD.0000000000014182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358397PMC
January 2019
1 Read

[The pathological characteristics and outcomes of 40 surgically treated stage M1b non-small cell lung cancer patients].

Zhonghua Zhong Liu Za Zhi 2019 Jan;41(1):63-67

Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

Clinical evidences of surgically treated stage M1b non-small cell lung cancer (NSCLC) patients were limited. This study aimed to summarize the clinical data of these patients to explore the prognostic factors of this population. From January 1999 to December 2012, the clinical data of 40 stage M1b NSCLC patients, including 24 males and 16 females, who underwent surgery were collected by Cancer Hospital, Chinese Academy of Medical Sciences. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0253-3766.2019.01.011DOI Listing
January 2019
1 Read

[The clinical and pathological features, biomarker characteristics and prognosis analysis of lung adenosquamous carcinoma].

Zhonghua Zhong Liu Za Zhi 2019 Jan;41(1):50-55

Department of Medical Oncology, Beijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted Drugs, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

Adenosquamous carcinoma of lung is an uncommon subtype with more aggressive behavior and poor prognosis than adenocarcinoma and squamous cell carcinoma. This study was aimed to investigate the clinicopathological characteristics and prognostic factors of lung adenosquamous carcinoma. The pathological features and follow-up data of 133 patients were collected and the prognostic factors of these patients were retrospectively analyzed. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0253-3766.2019.01.009DOI Listing
January 2019
2 Reads

Clonal MET Amplification as a Determinant of Tyrosine Kinase Inhibitor Resistance in Epidermal Growth Factor Receptor-Mutant Non-Small-Cell Lung Cancer.

J Clin Oncol 2019 Jan 24:JCO1800177. Epub 2019 Jan 24.

1 National Cancer Centre Singapore, Singapore.

Purpose: Mesenchymal epithelial transition factor ( MET) activation has been implicated as an oncogenic driver in epidermal growth factor receptor ( EGFR)-mutant non-small-cell lung cancer (NSCLC) and can mediate primary and secondary resistance to EGFR tyrosine kinase inhibitors (TKI). High copy number thresholds have been suggested to enrich for response to MET inhibitors. We examined the clinical relevance of MET copy number gain (CNG) in the setting of treatment-naive metastatic EGFR-mutant-positive NSCLC. Read More

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http://ascopubs.org/doi/10.1200/JCO.18.00177
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http://dx.doi.org/10.1200/JCO.18.00177DOI Listing
January 2019
14 Reads

Anaplastic lymphoma kinase fusions: Roles in cancer and therapeutic perspectives.

Oncol Lett 2019 Feb 20;17(2):2020-2030. Epub 2018 Dec 20.

Zhejiang Provincial Key Laboratory of Silkworm Bioreactors and Biomedicine, College of Life Sciences, Zhejiang Sci-Tech University, Hangzhou, Zhejiang 310018, P.R. China.

Receptor tyrosine kinase (RTK) anaplastic lymphoma kinase (ALK) serves a crucial role in brain development. is located on the short arm of chromosome 2 (2p23) and exchange of chromosomal segments with other genes, including nucleophosmin (), echinoderm microtubule-associated protein-like 4 () and -fused gene (), readily occurs. Such chromosomal translocation results in the formation of chimeric fusion oncoproteins, which possess potential oncogenic functions due to constitutive activation of ALK kinase. Read More

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http://www.spandidos-publications.com/10.3892/ol.2018.9856
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http://dx.doi.org/10.3892/ol.2018.9856DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341817PMC
February 2019
8 Reads

[Research Advances of JAK/STAT Signaling Pathway in Lung Cancer].

Zhongguo Fei Ai Za Zhi 2019 Jan;22(1):45-51

Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathway is one of the downstream pathways of cytokine signaling transduction. It regulates cell development, differentiation, proliferation, apoptosis and so on. The pathway is not only involved in the regulation of normal physiological processes, but also significant in the development of tumors, especially in hematologic malignancies. Read More

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http://dx.doi.org/10.3779/j.issn.1009-3419.2019.01.09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348154PMC
January 2019
2 Reads

Unusual endobronchial prostatic metastatic tumor occluding right main bronchus.

Asian Cardiovasc Thorac Ann 2019 Mar 23;27(3):228-230. Epub 2019 Jan 23.

2 Department of Thoracic Surgery, Liverpool Heart & Chest Hospital, Liverpool, UK.

Endobronchial metastasis from extrapulmonary solid tumors is rare, and endobronchial metastasis from the prostate is even more unusual. An 80-year-old patient presented with significant dyspnea secondary to metastatic stromal cell sarcoma of the prostate, which occluded the right main bronchus. The tumor, causing complete collapse of the right lung, was found on computed tomography and confirmed by bronchoscopy. Read More

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http://dx.doi.org/10.1177/0218492319827668DOI Listing
March 2019
5 Reads

[Differential Diagnosis of Erythrocytosis - Background and Clinical Relevance].

Dtsch Med Wochenschr 2019 Jan 23;144(2):128-135. Epub 2019 Jan 23.

Due to its rare incidence, erythrocytosis frequently represents a challenge for the treating doctors. The erythropoiesis (= production of erythrocytes) is located in the bone marrow, and the hormone erythropoietin (EPO) takes control in its regulation. Therefore, measurement of EPO in serum is one of the main diagnostic steps. Read More

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http://dx.doi.org/10.1055/a-0739-8340DOI Listing
January 2019
5 Reads

The need for bone biopsies in the diagnosis of new bone lesions in patients with a known primary malignancy: A comparative review of 117 biopsy cases.

J Bone Oncol 2019 Feb 18;14:100213. Epub 2018 Dec 18.

Department of Orthopedics, Zhongshan Hospital, Fudan University, 180# Fenglin Road, Xuhui district, Shanghai, China.

Objective: This study used a clinical dataset to investigate the proportion of the newly found bone lesions in malignant patients diagnosed by biopsy as being benign, malignant but unrelated to the primary malignancy, or bone metastases of the primary malignancy. The clinical factors that might affect the correlation between bone lesions and the primary malignancy were also analyzed. It is expected to obtain some information contributing to the clinical decision-making regarding the need for biopsy of these lesions from the research results. Read More

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http://dx.doi.org/10.1016/j.jbo.2018.100213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329701PMC
February 2019
1 Read

[A CASE WITH LATE RECURRENCE OF EXTRAGONADAL GERM CELL TUMOR].

Nihon Hinyokika Gakkai Zasshi 2018 ;109(1):40-44

Department of Urology, Nagoya University Graduate School of Medicine.

A 61-year-old man had undergone resection of teratoma with a histological component of seminoma occurring in the anterior mediastinum at 26 years of age in 1978, followed by radiation treatment to the resected area. He had a recurrence tumor in the left retroperitoneum 2 years later, which was resected combined with left nephrectomy and was proved to be the same pathology as the initial tumor. At 36 years after the initial treatment, the tumor recurred in the right lung. Read More

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http://dx.doi.org/10.5980/jpnjurol.109.40DOI Listing
February 2019
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[RETROPERITONEAL LIPOSARCOMA WITH MULTIPLE RECURRENCE OF LUNG METASTASES TREATED BY MULTIMODAL THERAPY CENTERING ON THE OPERATION: A CASE REPORT].

Nihon Hinyokika Gakkai Zasshi 2018 ;109(1):25-29

Department of Urology, Kanagawa Cancer Center.

A 34-year-old man presented with scrotal pain and slight fever. The scrotal pain was improved by the treatment of antibiotics, but the slight fever remained and an abdominal protuberance appeared. Computed tomography showed a 22 cm abdominal tumor with lipid density. Read More

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http://dx.doi.org/10.5980/jpnjurol.109.25DOI Listing
February 2019
1 Read

Surgical outcomes of early-stage small-cell lung cancer: single-center experience.

Asian Cardiovasc Thorac Ann 2019 Mar 19;27(3):187-191. Epub 2019 Jan 19.

Department of Thoracic Surgery, Gazi University Faculty of Medicine, Ankara, Turkey.

Background: Small-cell lung cancer is a highly aggressive and metastatic epithelial lung malignancy. A small percentage of these tumors can be detected at an early stage and may be appropriate for surgical treatment. We analyzed the data of patients with early-stage small-cell lung cancer who underwent lobectomy and mediastinal lymph node dissection. Read More

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http://dx.doi.org/10.1177/0218492319826724DOI Listing
March 2019
1 Read

Metastatic squamous cell carcinoma to the pancreas: Report of an extremely rare case.

Mol Clin Oncol 2019 Jan 1;10(1):144-146. Epub 2018 Nov 1.

Third Department of Surgery, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece.

Secondary pancreatic lesions are very uncommon. Resection of these metastatic lesions with a curative intent has been reported in selected patients; however, the survival benefit from these procedures has yet to be clearly determined. A 78-year-old male patient presented to our department with obstructive jaundice. Read More

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http://dx.doi.org/10.3892/mco.2018.1756DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313950PMC
January 2019

Population pharmacokinetics and individualized lobaplatin regimen for the treatment of Chinese small cell lung cancer in the elderly.

Medicine (Baltimore) 2019 Jan;98(3):e14136

Clinical Research Centre of Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Background: Lobaplatin (LBP) is a third-generation platinum compound.

Material And Methods: This prospective study was performed in 7 institutions in 2014-2016. Elderly small cell lung cancer (SCLC) patients (≥65 years old) were divided into 2 groups to receive LBP regimens according to endogenous creatinine clearance rate (Ccr). Read More

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http://dx.doi.org/10.1097/MD.0000000000014136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370119PMC
January 2019
5 Reads

Effect of pemetrexed on brain metastases from nonsmall cell lung cancer with wild-type and unknown EGFR status.

Authors:
Xiaoqing Yu Yun Fan

Medicine (Baltimore) 2019 Jan;98(3):e14110

Technology on Thoracic Oncology (Esophagus, Lung), Zhejiang Cancer Hospital, Hangzhou, Zhejiang, People's Republic of China.

We aimed to evaluate the effectiveness of pemetrexed-based chemotherapy in wild-type nonsmall-cell lung cancer (NSCLC) patients with brain metastases (BM). Brain metastases are a common cause of mortality in NSCLC patients. For epidermal growth factor receptor (EGFR) wild-type patients, therapeutic options for BM are even limited. Read More

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http://dx.doi.org/10.1097/MD.0000000000014110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370158PMC
January 2019
1 Read

Risk factors for bone metastasis in patients with primary lung cancer: A systematic review.

Medicine (Baltimore) 2019 Jan;98(3):e14084

Department of Oncology, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi.

Background: Bone metastases (BM) are prevalent among lung cancer (LC) patients. Although some studies revealed associated factors for BM, each of these papers focused on a few factors. Few studies have identified the potential risk factors through a systematic review. Read More

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http://dx.doi.org/10.1097/MD.0000000000014084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370015PMC
January 2019

Periprosthetic metastasis following total hip arthroplasty in a patient with lung carcinoma: A case report and review of literature.

Medicine (Baltimore) 2019 Jan;98(3):e14071

Department of Orthopedics, Artificial Joints Engineering and Technology Research Center of Jiangxi Province, The First Affiliated Hospital of Nanchang University, China.

Rationale: Periprosthetic osteolysis secondary to septic loosening and aseptic loosening is a well-described phenomenon associated with artificial hip arthroplasty. Periprosthetic bone loss as a result of metastatic infiltration is an uncommon cause of early, progressive loosening of joint replacement prosthesis and is rarely described in the literature.

Patient Concerns: The present study describes a 70-year-old male patient who was diagnosed with pulmonary squamous cell carcinoma 5 years after total hip arthroplasty (THA) and developed a metastasis from squamous cell carcinoma in the periprosthetic neosynovial tissue 1 year after formal chemotherapy. Read More

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http://dx.doi.org/10.1097/MD.0000000000014071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370114PMC
January 2019
1 Read

Solitary colonic metastasis from primary lung adenocarcinoma first presenting as intestinal obstruction: A case report.

Medicine (Baltimore) 2019 Jan;98(3):e14063

Department of Surgery.

Rationale: The brain, liver, adrenal glands, and bone are the most common sites of metastatic disease in patients with lung cancer. Symptomatic gastrointestinal metastases are rare. In the present report, we describe a rare case of a patient with intestinal obstruction due to solitary colonic metastasis from primary lung adenocarcinoma, wherein the intestinal obstruction was the first symptom of lung cancer. Read More

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http://dx.doi.org/10.1097/MD.0000000000014063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370174PMC
January 2019
1 Read

Seminal vesicle metastasis after liver transplantation for hepatocellular carcinoma: A case report.

Medicine (Baltimore) 2019 Jan;98(3):e13770

Department of Gastroenterology, The Affiliated Drum Tower Hospital of Nanjing University, Medical School.

Rationale: Cancer recurrence and metastasis after liver transplantation (LT) is common in some hepatocellular carcinoma (HCC) patients. The most common sites of extrahepatic metastases are lung, regional lymph node, adrenal gland, and bone. To our knowledge, HCC metastasis to the seminal vesicle after LT has not been reported in the literature. Read More

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http://dx.doi.org/10.1097/MD.0000000000013770DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370123PMC
January 2019
2 Reads

Vol-PACT: A Foundation for the NIH Public-Private Partnership That Supports Sharing of Clinical Trial Data for the Development of Improved Imaging Biomarkers in Oncology.

JCO Clin Cancer Inform 2018 12;2:1-12

Laurent Dercle, Binsheng Zhao, and Lawrence H. Schwartz, Columbia University Medical Center and New York Presbyterian Hospital; Mithat Gönen, Patrick Hilden, and Chaya S. Moskowitz, Memorial Sloan Kettering Cancer Center, New York, NY; Dana E. Connors and Stacey J. Adam, Foundation for the National Institutes of Health, North Bethesda, MD; Ying Tang, CCS Associates, San Jose, CA; Sanja Karovic and Michael Maitland, Inova Schar Cancer Institute, Fairfax, VA; Gary Kelloff, National Cancer Institute, Rockville, MD; and Geoffrey R. Oxnard, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA.

Purpose: To develop a public-private partnership to study the feasibility of a new approach in collecting and analyzing clinically annotated imaging data from landmark phase III trials in advanced solid tumors.

Patients And Methods: The collection of clinical trials fulfilled the following inclusion criteria: completed randomized trials of > 300 patients, highly measurable solid tumors (non-small-cell lung cancer, colorectal cancer, renal cell cancer, and melanoma), and required sponsor and institutional review board sign-offs. The new approach in analyzing computed tomography scans was to transfer to an academic image analysis laboratory, draw contours semi-automatically by using in-house-developed algorithms integrated into the open source imaging platform Weasis, and perform serial volumetric measurement. Read More

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http://ascopubs.org/doi/10.1200/CCI.17.00137
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http://dx.doi.org/10.1200/CCI.17.00137DOI Listing
December 2018
6 Reads

Nanoparticle-based drug delivery via RBC-hitchhiking for the inhibition of lung metastases growth.

Nanoscale 2019 Jan;11(4):1636-1646

Moscow Institute of Physics and Technology, Dolgoprudny, Moscow Region, Russia. and Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia and Prokhorov General Physics, Institute of the Russian Academy of Sciences, Moscow, Russia.

Delivery of particle-based theranostic agents via their transportation on the surfaces of red blood cells, commonly referred to as RBC-hitchhiking, has historically been developed as a promising strategy for increasing the extremely poor blood circulation lifetime, primarily, of the large-sized sub-micron agents. Here, we show for the first time that RBC-hitchhiking can be extremely efficient for nanoparticle delivery and tumor treatment even in those cases when no circulation prolongation is observed. Specifically, we demonstrate that RBC-hitchhiking of certain small 100 nm particles, unlike that of the conventional sub-micron ones, can boost the delivery of non-targeted particles to lungs up to a record high value of 120-fold (and up to 40% of the injected dose). Read More

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http://xlink.rsc.org/?DOI=C8NR07730D
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http://dx.doi.org/10.1039/c8nr07730dDOI Listing
January 2019
7 Reads

Loss of T790M mutation is associated with early progression to osimertinib in Chinese patients with advanced NSCLC who are harboring EGFR T790M.

Lung Cancer 2019 Feb 12;128:33-39. Epub 2018 Dec 12.

Department of Medical Oncology, Shanghai Pulmonary Hospital &Thoracic Cancer Institute, Tongji University School of Medicine, Shanghai, 200433, PR China. Electronic address:

Background: Osimertinib demonstrates superior efficacy in patients with non-small cell lung cancer (NSCLC) who acquired EGFR T790M mutation as resistant mechanism to upfront EGFR tyrosine kinase inhibitors (TKIs). Not all the T790M-positive tumors are homogeneously sensitive to osimertinib, however, and the duration of response often varies. Previous studies suggest that loss of T790 M at osimertinib resistance is correlated with shortened survival benefit of osimertinib. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01695002183069
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http://dx.doi.org/10.1016/j.lungcan.2018.12.010DOI Listing
February 2019
5 Reads
3.958 Impact Factor

Safety of transarterial radioembolization with Yttrium-90 glass microspheres without cystic artery occlusion.

Radiol Med 2019 Jan 11. Epub 2019 Jan 11.

Department of Nuclear Medicine, Yeditepe University Hospital, 34752, Atasehir, Istanbul, Turkey.

Purpose: To assess radiation-induced cholecystitis in cases of cystic artery origin nearby the treatment zone for transarterial radioembolization (TARE) treatment.

Materials And Methods: Patients with primary or secondary malignant liver tumors treated with TARE, in whom cystic artery was located in the surrounding area of the treatment zone on 99m-technetium-MAA angiograms, were included in this study. Whole liver dose, tumor dose and healthy injected liver dose, lung dose and if applicable the gallbladder dose were all calculated by using the Medical Internal Radiation Dose (MIRD) formula from SPECT-CT images. Read More

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http://dx.doi.org/10.1007/s11547-018-00984-9DOI Listing
January 2019
2 Reads

Improved survival among oral cancer patients: findings from a retrospective study at a tertiary care cancer centre in rural Kerala, India.

World J Surg Oncol 2019 Jan 11;17(1):15. Epub 2019 Jan 11.

Department of Surgical Oncology, Malabar Cancer Centre, Thalassery, Kerala, 670 103, India.

Background: Oral cancer is very common in India. The reported 5-year survival of such patients is around 50% after treatment with surgery and radiotherapy, much lower than most of the developed countries.

Methods: A retrospective study of a prospective database of oral cancer patients undergoing surgery from June 2009 to June 2013 was conducted. Read More

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http://dx.doi.org/10.1186/s12957-018-1550-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330462PMC
January 2019
1 Read

Deregulation of VEGFR-2 and PDGFR Expression and Microvascular Density in a Triple-Negative Model of Canine Malignant Mammary Tumors with Lymph Node or Lung Metastasis.

Vet Sci 2019 Jan 9;6(1). Epub 2019 Jan 9.

Department of Veterinary Surgery and Anesthesiology, School of Veterinary Medicine and Animal Science, São Paulo State University-UNESP, Botucatu 18618-681, Brazil.

Canine mammary tumors (CMT) represent the most common cancer in noncastrated female dogs. Interestingly, triple-negative tumors are the most common molecular subtype in female dogs. In this study, we proposed to evaluate the expression of vascular endothelial growth factor receptor 2 (VEGFR-2), Platelet-derived growth factor receptor (PDGFR), and microvascular density (MVD) in a group of metastatic and nonmetastatic triple-negative CMT and compare the expression based on clinical parameters. Read More

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http://www.mdpi.com/2306-7381/6/1/3
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http://dx.doi.org/10.3390/vetsci6010003DOI Listing
January 2019
5 Reads

The Pattern of Malignancies in Down Syndrome and Its Potential Context With the Immune System.

Front Immunol 2018 19;9:3058. Epub 2018 Dec 19.

Division of Pediatric Hematology Oncology, Department of Pediatric and Adolescent Medicine, Medical University Hospital, Graz, Austria.

The immune surveillance theory of cancer posits that the body's immune system detects and destroys randomly occurring malignant cells. This theory is based on the observation of the increased frequency of malignancies in primary and secondary immunodeficiencies, and is supported by the successful demonstration of immune augmentation in current oncological immune therapy approaches. We review this model in the context of Down syndrome (DS), a condition with a unique tumor profile and various immune defects. Read More

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https://www.frontiersin.org/article/10.3389/fimmu.2018.03058
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http://dx.doi.org/10.3389/fimmu.2018.03058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315194PMC
December 2018
10 Reads

Clinical Significance of Preoperative Embolization for Non-Hypervascular Metastatic Spine Tumors.

J Korean Neurosurg Soc 2019 Jan 31;62(1):106-113. Epub 2018 Dec 31.

Department of Orthopedic Surgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Objective: The efficacy of preoperative embolization for hypervascular metastatic spine disease (MSD) such as renal cell and thyroid cancers has been reported. However, the debate on the efficacy of preoperative embolization for non-hypervascular MSD still remains unsettled. The purpose of this study is to determine whether preoperative embolization for non-hypervascular MSD decreases perioperative blood loss. Read More

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http://dx.doi.org/10.3340/jkns.2018.0073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328796PMC
January 2019
1 Read

Brain Metastases and Place of Antiangiogenic Therapies in Alveolar Soft Part Sarcoma: A Retrospective Analysis of the French Sarcoma Group.

Oncologist 2019 Jan 9. Epub 2019 Jan 9.

Department of Cancer Medicine, Gustave Roussy Cancer Campus, Villejuif, France.

Background: Alveolar soft part sarcoma (ASPS) is a rare sarcoma characterized by a slow evolution, brain metastasis (BM), and resistance to doxorubicin. Antiangiogenic therapies (AAT) have shown clinical activity, but little is known about the optimal therapeutic strategy, specifically considering BM.

Subjects, Materials, And Methods: We performed a retrospective analysis of all patients with ASPS treated in three referral centers of the French Sarcoma Group. Read More

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http://dx.doi.org/10.1634/theoncologist.2018-0074DOI Listing
January 2019
1 Read

Radiation-associated epithelial-myoepithelial carcinoma among five secondary malignancies: A case report and review of literature.

World J Clin Oncol 2018 Dec;9(8):200-207

Department of Radiation Oncology, Vanderbilt University Medical Center, Nashville, TN 37232, United States.

Background: Epithelial-myoepithelial carcinoma (EMC) is a rare, low-grade, malignant tumor that constitutes less than one percent of all salivary gland tumors. To date, only one other case report has described radiation-associated EMC in the English language medical literature.

Case Summary: In this report, we describe the case of a 56-year-old male patient who presented with a neck mass diagnosed as EMC of the left submandibular gland approximately 30 years after mantle field radiation and chemotherapy for Hodgkin lymphoma. Read More

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https://www.wjgnet.com/2218-4333/full/v9/i8/200.htm
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http://dx.doi.org/10.5306/wjco.v9.i8.200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314863PMC
December 2018
2 Reads

Living donor liver transplantation with two-stage hepatectomy for patients with isolated, irresectable colorectal liver-the LIVER-T(W)O-HEAL study.

World J Surg Oncol 2019 Jan 8;17(1):11. Epub 2019 Jan 8.

Department of General, Visceral and Vascular Surgery, Jena University Hospital, 07747, Jena, Germany.

Background: Colorectal cancer is the third most common malignancy worldwide. The occurrence of liver metastases worsens the prognosis of the patient significantly if the tumor burden is not resectable. Liver transplantation might be an option for otherwise irresectable colorectal liver metastases. Read More

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http://dx.doi.org/10.1186/s12957-018-1549-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325801PMC
January 2019
3 Reads

Antigen-Specific IgG Subclasses in Primary and Malignancy-Associated Membranous Nephropathy.

Front Immunol 2018 20;9:3035. Epub 2018 Dec 20.

III. Medizinische Klinik und Poliklinik, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany.

Membranous nephropathy (MN) is an autoimmune disease caused by binding of circulating antibodies to podocyte antigens in the kidney. For decades and still today primary MN has been considered to have an unspecified IgG4-driven autoimmune genesis, while secondary MN has been associated with other diseases, most notably cancer, and not linked to IgG4. Immunologic mechanisms of primary and malignancy-associated MN are assumed to be different, however, this has never been systematically evaluated. Read More

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https://www.frontiersin.org/article/10.3389/fimmu.2018.03035
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http://dx.doi.org/10.3389/fimmu.2018.03035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306563PMC
December 2018
6 Reads

Leucurogin and melanoma therapy.

Toxicon 2019 Mar 3;159:22-31. Epub 2019 Jan 3.

Federal Institute of Education, Science and Technology of São Paulo, Suzano, São Paulo, Brazil.

Leucurogin is an ECD disintegrin-like protein, cloned from Bothrops leucurus venom gland. This new protein, encompassing the disintegrin region of a PIII metalloproteinase, is produced by recombinant technology and its biological and functional activity was partially characterized in this study. Biological activity was characterized in vitro using human fibroblasts. Read More

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http://dx.doi.org/10.1016/j.toxicon.2018.12.005DOI Listing
March 2019
3 Reads

First- and Second-Generation EGFR-TKIs Are All Replaced to Osimertinib in Chemo-Naive Mutation-Positive Non-Small Cell Lung Cancer?

Int J Mol Sci 2019 Jan 3;20(1). Epub 2019 Jan 3.

Department of Medical Oncology, Kindai University Faculty of Medicine, 377-2 Ohno-higashi, Osaka-Sayama, Osaka 589-8511, Japan.

Activating mutations of the epidermal growth factor receptor gene () are a driving force for some lung adenocarcinomas. Several randomized phase III studies have revealed that treatment with first- or second-generation EGFR tyrosine kinase inhibitors (TKIs) results in an improved progression-free survival (PFS) compared to standard chemotherapy in chemonaive patients with advanced non⁻small cell lung cancer (NSCLC), selected based on the presence of mutations. Patients treated with second-generation EGFR-TKIs have also shown an improved PFS relative to those treated with first-generation EGRF-TKIs. Read More

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http://www.mdpi.com/1422-0067/20/1/146
Publisher Site
http://dx.doi.org/10.3390/ijms20010146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337322PMC
January 2019
9 Reads

Dual-Tracer PET/CT Differentiates 2 Types of Primary Cancers and Metastases in a Patient With Crossed Fused Renal Ectopia.

Clin Nucl Med 2019 Feb;44(2):157-158

From the Department of Nuclear Medicine & PET and.

A patient was found incidentally on dual-tracer (C-acetate [ACT] and F-FDG [FDG]) PET/CT for having crossed fused renal ectopia and 2 types of malignant tumors, colonic carcinoma and renal cell carcinoma (RCC), each having its own characteristic tracer avidity. Multiple liver metastases were also mutually exclusive, with a purely ACT-avid group of metastatic lesions from RCC and another FDG-avid group from colonic carcinoma. Bone and lung metastases, however, could not be readily distinguishable in terms of primary origins. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002390DOI Listing
February 2019
2 Reads

Successful Treatment of Lung Adenocarcinoma with Epidermal Growth Factor Receptor Compound Mutations Involving Exon 19 Deletion and Exon 20 Insertion by Afatinib.

Intern Med 2019 1;58(1):101-104. Epub 2019 Jan 1.

Department of Respiratory Medicine, Matsue Red Cross Hospital, Japan.

A 70-year-old woman was referred to our hospital after a nodular shadow was noted on chest X-ray. Chest computed tomography showed a pulmonary mass in the right upper lobe, and brain magnetic resonance imaging revealed a right-sided frontal lobe tumor. A histological examination of a transbronchial lung biopsy specimen revealed adenocarcinoma with epidermal growth factor receptor mutations involving both exon 19 deletion and exon 20 insertion. Read More

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http://dx.doi.org/10.2169/internalmedicine.0927-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367085PMC
February 2019
3 Reads