73,154 results match your criteria Secondary Lung Tumors


Targeting STAT3 signaling using stabilised sulforaphane (SFX-01) inhibits endocrine resistant stem-like cells in ER-positive breast cancer.

Oncogene 2020 May 30. Epub 2020 May 30.

Breast Biology Group, Manchester Breast Centre, Division of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.

Estrogen receptor (ER) positive breast cancer is frequently sensitive to endocrine therapy. Multiple mechanisms of endocrine therapy resistance have been identified, including cancer stem-like cell (CSC) activity. Here we investigate SFX-01, a stabilised formulation of sulforaphane (SFN), for its effects on breast CSC activity in ER+ preclinical models. Read More

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http://dx.doi.org/10.1038/s41388-020-1335-zDOI Listing

Uncommon thoracic manifestations from extrapulmonary tumors: Computed tomography evaluation - Pictorial review.

Respir Med 2020 Jul 28;168:105986. Epub 2020 Apr 28.

Hospital de Sant Pau, Universitat Autónoma de Barcelona, Barcelona, Spain. Electronic address:

Although metastasis can occur at a variety of sites, pulmonary involvement is common in patients with cancer. Depending on the source and type of tumor, pulmonary metastases present with a wide range of radiologic appearances. Hematogenous dissemination through the pulmonary arteries to the pulmonary capillary network is the most common form of spread in pulmonary metastases. Read More

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http://dx.doi.org/10.1016/j.rmed.2020.105986DOI Listing

The genomic landscape of metastasis in treatment-naïve breast cancer models.

PLoS Genet 2020 May 28;16(5):e1008743. Epub 2020 May 28.

Laboratory of Cancer Biology and Genetics, Metastasis Susceptibility Section, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America.

Metastasis remains the principle cause of mortality for breast cancer and presents a critical challenge because secondary lesions are often refractory to conventional treatments. While specific genetic alterations are tightly linked to primary tumor development and progression, the role of genetic alteration in the metastatic process is not well-understood. The theory of tumor evolution postulated by Peter Nowell in 1976 has yet to be proven in the context of metastasis. Read More

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http://dx.doi.org/10.1371/journal.pgen.1008743DOI Listing

Pulmonary Delivery of Nanoparticle-Bound Toll-Like Receptor 9 Agonist for the Treatment of Metastatic Lung Cancer.

ACS Nano 2020 May 28. Epub 2020 May 28.

CpG oligodeoxynucleotides (ODNs) are potent toll-like receptor (TLR) 9 agonists and have shown promise as anti-cancer agents in preclinical studies and clinical trials. Binding of CpG to TLR9 initiates a cascade of innate and adaptive immune responses, beginning with activation of dendritic cells, and resulting in a range of secondary effects that include the secretion of pro-inflammatory cytokines, activation of natural killer (NK) cells, and expansion of T cell populations. Recent literature suggests that local delivery of CpG in tumors results in superior antitumor effects as compared to systemic delivery. Read More

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http://dx.doi.org/10.1021/acsnano.0c02207DOI Listing

Phase I study of bintrafusp alfa, a bifunctional fusion protein targeting TGF-β and PD-L1, in patients with pretreated biliary tract cancer.

J Immunother Cancer 2020 May;8(1)

Department of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital East, Kashiwa, Japan

Background: Patients with biliary tract cancer (BTC) have poor prognosis with few treatment options. Bintrafusp alfa, a first-in-class bifunctional fusion protein composed of the extracellular domain of the transforming growth factor (TGF)-βRII receptor (a TGF-β 'trap') fused to a human IgG1 antibody blocking programmed death ligand 1 (PD-L1), has shown clinical efficacy in multiple solid tumors.

Methods: In this phase I, open-label trial expansion cohort, Asian patients with BTC whose disease progressed after first-line chemotherapy received bintrafusp alfa 1200 mg every 2 weeks until disease progression, unacceptable toxicity, or withdrawal. Read More

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http://dx.doi.org/10.1136/jitc-2020-000564DOI Listing

[Often Only a Side Event, but Sometimes Groundbreaking - an Ectopic ACTH Secretion as an Example of a Paraneoplastic Syndrome].

Praxis (Bern 1994) 2020 ;109(7):517-519

Innere Medizin, Kantonsspital Graubünden, Chur.

Often Only a Side Event, but Sometimes Groundbreaking - an Ectopic ACTH Secretion as an Example of a Paraneoplastic Syndrome Various tumors can cause a paraneoplastic ACTH production, particularly small-cell lung cancers. Patients suffer from a secondary Cushing syndrome with hypokalemia, hypertension, hyperglycemia and edema. There are three therapeutic approaches: treatment of the underlying disease, hormonal inhibition and symptomatic treatment. Read More

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http://dx.doi.org/10.1024/1661-8157/a003433DOI Listing
January 2020

Vitamin D, melanoma risk, and tumor thickness in PLCO cancer screening trial patients.

JAAPA 2020 Jun;33(6):35-41

At the University of Utah Health Sciences Center in Salt Lake City, Mark A. Hyde is an assistant professor of dermatology at the Huntsman Cancer Institute and an assistant professor in the department of community and public health at Utah Valley University, Douglas Grossman is a professor in the Department of Dermatology and codirector of the melanoma and cutaneous oncology program at the Huntsman Cancer Institute, Yelena P. Wu is an assistant professor in the Department of Dermatology, Saundra Buys is a professor in the Department of Medicine and medical director of the High Risk Breast Cancer Clinic at the Huntsman Cancer Institute, Lisa H. Gren is an associate professor in the Department of Family and Preventive Medicine, and Mia Hashibe is an associate professor in the Department of Family and Preventive Medicine and at the Huntsman Cancer Institute. This work was supported by the National Cancer Institute (NCI) of the National Institutes of Health (K07CA196985). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health or NCI. The authors have disclosed no other potential conflicts of interest, financial or otherwise.

Objective: The incidence of melanoma is increasing. Other than limiting UV exposure, few factors prevent or reduce the risk of melanoma. The aim of this study is to evaluate the relationship between vitamin D intake and melanoma risk in the Prostate, Lung, Colorectal, and Ovarian (PLCO) cancer screening trial. Read More

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http://dx.doi.org/10.1097/01.JAA.0000662388.18867.42DOI Listing

Fatty Acid Synthase Inhibitor G28 Shows Anticancer Activity in EGFR Tyrosine Kinase Inhibitor Resistant Lung Adenocarcinoma Models.

Cancers (Basel) 2020 May 19;12(5). Epub 2020 May 19.

New Therapeutic Targets Laboratory (TargetsLab)-Oncology Unit, Department of Medical Sciences, Faculty of Medicine, University of Girona, 17003 Girona, Spain.

Epidermal growth factor receptor (EGFR) tyrosine kinases inhibitors (TKIs) are effective therapies for non-small cell lung cancer (NSCLC) patients whose tumors harbor an EGFR activating mutation. However, this treatment is not curative due to primary and secondary resistance such as T790M mutation in exon 20. Recently, activation of transducer and activator of transcription 3 (STAT3) in NSCLC appeared as an alternative resistance mechanism allowing cancer cells to elude the EGFR signaling. Read More

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http://dx.doi.org/10.3390/cancers12051283DOI Listing

Immune Checkpoint Inhibitor-induced Fanconi Syndrome.

Cureus 2020 Apr 16;12(4):e7686. Epub 2020 Apr 16.

Oncology, Georgetown University Hospital, Washington, D.C, USA.

Immune checkpoint inhibitors (ICI) have been approved by the Food and Drug Administration (FDA) for use in many solid tumors and hematological malignancies. Immune-related adverse events (irAEs) are potential side effects that can arise during or after treatment with ICI therapy. We describe a case of ICI-induced Fanconi syndrome in a 58-year-old man with extensive-stage small-cell lung cancer (ES-SCLC), who had disease progression after initial chemotherapy and radiation. Read More

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http://dx.doi.org/10.7759/cureus.7686DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7233517PMC

[Gene Fusions as Acquired Resistance Mechanisms of EGFR-TKI].

Zhongguo Fei Ai Za Zhi 2020 May;23(5):381-387

Department of Medical Oncology, Tianjin Medical University General Hospital, Tianjin 300052, China.

Patients with sensitive epidermal growth factor receptor (EGFR) mutations often respond to tyrosine kinase inhibitors (TKIs), but acquired resistance will eventually develop. The most common mechanisms of acquired resistance include secondary EGFR mutation, MET amplification, and histologic transformation. Besides, gene fusions could also mediate the process of acquired resistance. Read More

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http://dx.doi.org/10.3779/j.issn.1009-3419.2020.101.04DOI Listing

The Prognostic Role of High Blood Cholesterol in Advanced Cancer Patients Treated With Immune Checkpoint Inhibitors.

J Immunother 2020 May 12. Epub 2020 May 12.

Medical Oncology Unit, University Hospital of Parma.

Immune checkpoint inhibitors (ICI) have improved survival in numerous types of cancer. However, a great number of unselected patients still do not respond to ICI. Moreover, there is a need to identify biomarkers that could predict the prognosis of immunotherapy-treated patients. Read More

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http://dx.doi.org/10.1097/CJI.0000000000000321DOI Listing

Ocular metastases from neuroendocrine tumors: A literature review.

Semin Oncol 2020 May 6. Epub 2020 May 6.

Department of Oncology, University of Turin, San Luigi Gonzaga Hospital, Orbassano, TO, Italy.

Background Neuroendocrine tumors (NETs) include malignancies with different origins, clinical presentations and prognosis. Synchronous or metachronous ocular metastases from NET are extremely rare. The diagnostic algorithm and the management of this entity has not been established. Read More

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http://dx.doi.org/10.1053/j.seminoncol.2020.04.003DOI Listing

The Day My Gut Feeling Led Me Astray.

Authors:
Vanita Noronha

N Engl J Med 2020 May;382(20):1880-1881

From the Department of Medical Oncology, Tata Memorial Hospital, Parel, and the Homi Bhabha National Institute - both in Mumbai, India.

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http://dx.doi.org/10.1056/NEJMp1917572DOI Listing

Single-Institution Experience with Selective Internal Radiation Therapy (SIRT) for the Treatment of Primary and Secondary Hepatic Tumors.

Cureus 2020 Apr 10;12(4):e7628. Epub 2020 Apr 10.

General Surgery, Lebanese American University Medical Center, Beirut, LBN.

Purpose: We aim to provide results of the real-world experience of a single center in Lebanon on the use of radioembolization to treat liver-only or liver-dominant tumors.  Methods: This retrospective review included patients who were evaluated for radioembolization between January 2015 and June 2017 and who had a lung shunt fraction of 20% or less. Tumor responses were determined using the response evaluation criteria in solid tumors (RECIST). Read More

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http://dx.doi.org/10.7759/cureus.7628DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7213655PMC

Association of lncRNA-p53 regulatory network (lincRNA-p21, lincRNA-ROR and MALAT1) and p53 with the clinicopathological features of colorectal primary lesions and tumors.

Oncol Lett 2020 Jun 7;19(6):3937-3949. Epub 2020 Apr 7.

Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran 1985717413, Iran.

Colorectal cancer (CRC) is a common intestinal cancer with a high mortality rate. Early detection of this type of cancer is fundamental to the prevention of the disease, which results in improved survival rates. In the human colon tissue, transition from normal epithelium to adenoma is considered to be caused by unknown molecular incidents occurring over 5-10 years. Read More

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http://dx.doi.org/10.3892/ol.2020.11518DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204634PMC
June 2020
0.987 Impact Factor

Prostate-specific membrane antigen expression in the vasculature of primary lung carcinomas associates with faster metastatic dissemination to the brain.

J Cell Mol Med 2020 May 11. Epub 2020 May 11.

Translational Cancer Medicine Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.

Glioblastomas and brain metastases (BM) of solid tumours are the most common central nervous system neoplasms associated with very unfavourable prognosis. In this study, we report the association of prostate-specific membrane antigen (PSMA) with various clinical parameters in a large cohort of primary and secondary brain tumours. A tissue microarray containing 371 cases of ascending grades of gliomas pertaining to astrocytic origin and samples of 52 cases of primary lung carcinomas with matching BM with follow-up time accounting to 10. Read More

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http://dx.doi.org/10.1111/jcmm.15350DOI Listing

[Adenocarcinoma in the Lung Detected Due to the Development of Perforative Peritonitis Caused by Small Intestinal Metastasis-A Case Report].

Gan To Kagaku Ryoho 2020 Apr;47(4):706-708

Dept. of Surgery, Reimeikai Kitade Hospital.

Previous studies have reported that perforations of the small intestine caused by metastatic tumors prior to the diagnosis of primary lung cancer are very rare. A 79-year-old man was admitted to our hospital with acute lower abdominal pain. Abdominal computed tomography revealed intraperitoneal free air around the bowel wall thickening in the small intestine. Read More

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Skeletal muscle metastasis as a first site of recurrence of cervical cancer: A case report and review of the literature.

Medicine (Baltimore) 2020 May;99(19):e20056

Department of Obstetrics and Gynecology.

Rationale: Cervical cancer primarily spreads through direct invasion or via local lymphatics, and hematogenous metastasis is infrequent. Previous reports have shown that lung, liver, and bone are the organs most frequently affected by hematogenous metastasis of cervical cancer, while skeletal muscle is very rarely involved.

Patient Concerns: A 75-year-old Japanese woman presented with a painful muscular mass in her right lower abdomen. Read More

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http://dx.doi.org/10.1097/MD.0000000000020056DOI Listing

Malignant pulmonary embolism associated with renal sarcoma: A case report.

Medicine (Baltimore) 2020 May;99(19):e19943

Department of Thoracic and Cardiovascular Surgery, Changwon.

Rationale: The preoperative diagnosis of massive pulmonary tumor embolism associated with renal neoplasms is relatively rare. In most cases, pulmonary tumor embolism is detected intraoperatively during renal tumor resection. Moreover, primary renal sarcoma is rare, and primary renal sarcoma complicated by pulmonary tumor embolism is extremely rare; accordingly, there is no optimal treatment for such cases. Read More

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http://dx.doi.org/10.1097/MD.0000000000019943DOI Listing

Metastatic rectal cancer to papillary thyroid carcinoma: a case report and review of literature.

BMC Gastroenterol 2020 May 6;20(1):136. Epub 2020 May 6.

Department of Medical Oncology, Guangxi Medical University Cancer Hospital, No.71, Hedi road, Nanning, 530021, PR China.

Background: Tumor-to-tumor metastasis is a rare event. Rectal cancer to primary thyroid neoplasm metastasis is extremely rare. Herein, we reported a case of metastatic rectal adenocarcinoma to a papillary thyroid carcinoma. Read More

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http://dx.doi.org/10.1186/s12876-020-01286-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204023PMC

Breakthrough Pain in Patients with Lung Cancer. A Secondary Analysis of IOPS MS Study.

J Clin Med 2020 May 4;9(5). Epub 2020 May 4.

Department of Medical Oncology, AUSL Teramo, 64100 Teramo, Italy.

Aim: To characterize breakthrough cancer pain (BTcP) in patients with lung cancer.

Methods: This was a secondary analysis of multicenter study of patients with BTcP. Background pain intensity and opioid dose were recorded. Read More

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http://dx.doi.org/10.3390/jcm9051337DOI Listing

Current status of lung cancer in Spain: a retrospective analysis of patient characteristics, use of healthcare resources and in-hospital mortality.

Curr Med Res Opin 2020 May 15:1-7. Epub 2020 May 15.

BCN Health Economics & Outcomes Research S.L, Barcelona, Spain.

This study aimed to describe the current status of lung cancer in Spain, including patient characteristics and in-hospital mortality, and to revise disease management and the direct medical costs of secondary care. A retrospective observational study was set to analyse anonymized primary and secondary care records of patients admitted with lung cancer in Spain between 2011 and 2016. Data were obtained from the Primary Care Dataset and the Centralised Hospital Discharge Database. Read More

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http://dx.doi.org/10.1080/03007995.2020.1765153DOI Listing

Tumour biomarkers: association with heart failure outcomes.

J Intern Med 2020 May 5. Epub 2020 May 5.

From the, Department of Cardiology, Uni, University Medical Center Groningen, Groningen, the Netherlands.

Background: There is increasing recognition that heart failure (HF) and cancer are conditions with a number of shared characteristics.

Objectives: To explore the association between tumour biomarkers and HF outcomes.

Methods: In 2,079 patients of BIOSTAT-CHF cohort, we measured six established tumour biomarkers: CA125, CA15-3, CA19-9, CEA, CYFRA 21-1 and AFP. Read More

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http://dx.doi.org/10.1111/joim.13053DOI Listing

Comparison of personal and shared frameshift neoantigen vaccines in a mouse mammary cancer model.

BMC Immunol 2020 May 5;21(1):25. Epub 2020 May 5.

Center for Innovations in Medicine, The Biodesign Institute, Arizona State University, Tempe, AZ, 85287, USA.

Background: It is widely hoped that personal cancer vaccines will extend the number of patients benefiting from checkpoint and other immunotherapies. However, it is clear creating such vaccines will be challenging. It requires obtaining and sequencing tumor DNA/RNA, predicting potentially immunogenic neoepitopes and manufacturing a one-use vaccine. Read More

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http://dx.doi.org/10.1186/s12865-020-00350-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201681PMC
May 2020
2.481 Impact Factor

Synchronous high-grade bladder carcinoma associated with chronic lymphocytic leukemia: A rare entity in Indian literature.

J Cancer Res Ther 2020 Jan-Mar;16(1):180-182

Department of Pathology, Dayanand Medical College and Hospital, Ludhiana, Punjab, India.

B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL) is one of the common lymphoproliferative disorders with an increased risk of developing subsequent neoplasms of epithelial and mesenchymal origin. The decreased immunity and B-cell dysfunction in CLL probably accounts for this emergence of secondary malignancy. Breast, brain, skin and prostate tumors have been reported as usual coincident malignancies of CLL, while in occasional cases CLL may occur with malignancies of other solid organs, such as skin, lung, heart, and prostate. Read More

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http://dx.doi.org/10.4103/jcrt.JCRT_642_16DOI Listing

Case Report of Immuno-Oncotherapy (IO) Provoked Encephalitis Mimicking Brain Metastasis in a Patient with History of Traumatic Brain Injury.

World Neurosurg 2020 Apr 30. Epub 2020 Apr 30.

Neuroscience Institute; Cancer Institute. Electronic address:

Background: Immuno-oncotherapy (IO) has revolutionized systemic cancer care but remains experimental in brain tumors. IO treatment risks multi-organ autoimmune inflammatory responses that limit its use. The CNS is an immune specialized compartment with restricted cellular access, thus fewer cases reported for immune-mediated encephalitis. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.04.177DOI Listing

Development and evaluation of a venous computed tomography radiomics model to predict lymph node metastasis from non-small cell lung cancer.

Medicine (Baltimore) 2020 May;99(18):e20074

Department of Computed Tomography and Magnetic Resonance, Hebei Medical University Fourth Affiliated Hospital and Hebei Provincial Tumor Hospital, Shijiazhuang, Hebei Province.

The objective of this study was to develop a venous computed tomography (CT)-based radiomics model to predict the lymph node metastasis (LNM) in patients with non-small cell lung cancer (NSCLC). A total of 411 consecutive patients with NSCLC underwent tumor resection and lymph node (LN) dissection from January 2018 to September 2018 in our hospital. A radiologist with 20 years of diagnostic experience retrospectively reviewed all CT scans and classified all visible LNs into LNM and non-LNM groups without the knowledge of pathological diagnosis. Read More

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http://dx.doi.org/10.1097/MD.0000000000020074DOI Listing

Dosimetric Comparison of Treatment Plans Computed With Finite Size Pencil Beam and Monte Carlo Algorithms Using the InCise™ Multileaf Collimator-Equipped Cyberknife System.

J Med Phys 2020 Jan-Mar;45(1):7-15. Epub 2020 Mar 13.

Department of Physics, Florida Atlantic University, Boca Raton, Florida, USA.

Purpose: InCise™ multileaf collimator (MLC) was introduced for CyberKnife (CK) Robotic Radiosurgery System (CK-MLC) in 2015, and finite size pencil beam (FSPB) was the only available dose computation algorithm for treatment plans of CK-MLC system. The more advanced Monte Carlo (MC) dose calculation algorithm of lnCise™ was initially released in 2017 for the CK Precision™ treatment planning system (TPS) (v1.1) with new graphic processing unit (GPU) platform. Read More

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http://dx.doi.org/10.4103/jmp.JMP_64_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185708PMC

Mesenteric lymphadenopathy is a key to diagnosis of radiologically challenging pulmonary lymphoma.

Thorac Cancer 2020 Jun 29;11(6):1738-1740. Epub 2020 Apr 29.

Department of Radiology, MacKay Memorial Hospital, Taipei, Taiwan.

Extranodal marginal zone B-cell lymphoma (EMZBL), previously known as mucosa-associated lymphoid tissue lymphoma, is the most common type of marginal zone B-cell lymphomas. Primary pulmonary lymphomas only constitute 0.5% of primary lung cancer, but 90% of these are EMZBLs. Read More

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http://dx.doi.org/10.1111/1759-7714.13453DOI Listing

Cancer incidence and mortality trends in young adults in Metropolitan Lima young adults, 1990-2012.

Ecancermedicalscience 2020 20;14:1025. Epub 2020 Apr 20.

Department of Nuclear Medicine, National Institute of Neoplastic Diseases, Lima, Peru.

Aims: The purpose of this research was to calculate and compare standardised incidence and mortality ratios in young adults, based on the data published by the population-based cancer registry of Metropolitan Lima.

Method: A secondary analysis was carried out on the data published by the population-based cancer registry of Metropolitan Lima in its last five volumes. Calculating the standardised incidence ratio, in accordance with the World Health Organization's standard population, was done using the direct method, and the annual percentage change was calculated using the Joinpoint Regression Program. Read More

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http://dx.doi.org/10.3332/ecancer.2020.1025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176066PMC

Gefitinib as neoadjuvant therapy for resectable stage II-IIIA non-small cell lung cancer: A phase II study.

J Thorac Cardiovasc Surg 2020 Mar 19. Epub 2020 Mar 19.

Department of Thoracic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China; Institute of Thoracic Oncology, Fudan University, Shanghai, China; State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China. Electronic address:

Introduction: Currently, limited data on tyrosine kinase inhibitors as neoadjuvant therapy exist. This prospective study aimed to investigate the efficacy and safety of preoperative gefitinib in patients with stage II-IIIA operable non-small cell lung cancer (NSCLC).

Methods: This was a single-arm, phase II trial performed in the Shanghai Cancer Center. Read More

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http://dx.doi.org/10.1016/j.jtcvs.2020.02.131DOI Listing
March 2020
4.168 Impact Factor

Quality of life after pulmonary stereotactic fractionated radiotherapy (SBRT): Results of the phase II STRIPE trial.

Radiother Oncol 2020 Apr 6;148:82-88. Epub 2020 Apr 6.

Department of Radiation Oncology, Medical Center, Faculty of Medicine, University of Freiburg, Germany; German Cancer Consortium (DKTK) Partner Site Freiburg, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany.

Background And Purpose: Preserving health related quality of life (HRQOL) plays an important role in considering stereotactic body fractionated radiotherapy (SBRT). The prospective monocenter phase II STRIPE trial investigated long-term HRQOL after SBRT, efficacy and toxicity.

Materials And Methods: Patients with ≤2 pulmonary lesions ≤5 cm were treated with 4DPET/CT-based SBRT (3 × 12. Read More

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http://dx.doi.org/10.1016/j.radonc.2020.03.018DOI Listing

ROS1-rearranged Non-small Cell Lung Cancer.

Thorac Surg Clin 2020 May;30(2):147-156

UCSD Moores Cancer Center, 3855 Health Sciences Drive MC #0987, La Jolla, CA 92093-0829, USA. Electronic address:

ROS1-rearranged non-small cell lung cancer (NSCLC) makes up approximately 1% to 2% of all NSCLC, is oncogenically driven by a constitutively activated ROS1 kinase paired with certain fusion partners, and can be detected by several different assays. These patients are initially treated with tyrosine kinase inhibitors (TKIs), which target the activated ROS1 kinase. Eventually these tumors develop resistance to initial TKI treatment through secondary kinase mutations that block TKI binding or activation of bypass signaling pathways, which subvert ROS1 as the driver of the malignancy. Read More

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http://dx.doi.org/10.1016/j.thorsurg.2020.01.007DOI Listing

Association of metastatic pattern and molecular status in stage IV non-small cell lung cancer adenocarcinoma.

Eur Radiol 2020 Apr 23. Epub 2020 Apr 23.

Imaging Department, Gustave Roussy, Université Paris-Saclay, F-94805, Villejuif, France.

Objectives: The aim of our study was to investigate the association between driver oncogene alterations and metastatic patterns on imaging assessment, in a large cohort of metastatic lung adenocarcinoma patients.

Methods: From January 2010 to May 2017, 550 patients with stage IV lung adenocarcinoma with molecular analysis were studied retrospectively including 135 EGFR-mutated, 81 ALK-rearrangement, 47 BRAF-mutated, 141 KRAS-mutated, and 146 negative tumors for these 4 mutations (4N). After review of the complete imaging report by two radiologists (junior and senior) to identify metastatic sites, univariate correlation analyzes were performed. Read More

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http://dx.doi.org/10.1007/s00330-020-06784-yDOI Listing

Single Solitary Fibrous Tumor Brain Metastasis in a Patient with Simultaneous Adenocarcinoma of the Lung: Case Report and Review of the Literature.

Case Rep Med 2020 7;2020:3938270. Epub 2020 Apr 7.

Department of Radiation Oncology, Cancer Care Northwest and Gamma Knife of Spokane, Spokane, WA, USA.

We present a unique case of a patient simultaneously diagnosed with solitary fibrous tumor (SFT) and unrelated adenocarcinoma of the lung, both proven with separate pathology. It was subsequently found that the SFT had metastasized to the brain by additional pathology, and not the predicted adenocarcinoma. SFTs are a rare mesenchymal neoplasm that accounts for less than 2% of all reported soft tissue tumors. Read More

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http://dx.doi.org/10.1155/2020/3938270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7166291PMC

Clinical significance of serum neuron-specific enolase in gastric adenocarcinoma.

Medicine (Baltimore) 2020 Apr;99(16):e19829

China-Japan Union Hospital of Jilin University, Changchun, Jilin Province, China.

As a biomarker, neuron-specific enolase (NSE) has been widely recognized in the diagnosis of benign diseases and malignant tumors. This study aimed to investigate the potential diagnostic value of NSE in patients with gastric adenocarcinoma.Serum levels of the NSE were compared between 219 patients with gastric adenocarcinoma and 298 healthy individuals, NSE and clinicopathological parameters were analyzed. Read More

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http://dx.doi.org/10.1097/MD.0000000000019829DOI Listing

[Analysis of robotic natural orifice specimen extraction surgery on 162 cases with rectal neoplasms].

Zhonghua Wei Chang Wai Ke Za Zhi 2020 Apr;23(4):384-389

Department of General Surgery, the Second Xiangya Hospital, Central South University, Changsha 410011, China.

To explore the safety and feasibility of da Vinci robot surgical systems in natural orifice specimen extraction surgery (NOSES) for rectal neoplasms. A descriptive cohort study was used. Inclusion criteria: (1) age ≥18 years old; (2) diagnosis of rectal cancer by biopsy via colonoscopy or benign neoplasm locating in rectum that could not be resected locally through the anus; (3) R0 resection can be achieved by preoperative evaluation; (4) the CDmax (maximum circumferential diameter) was ≤5 cm or specimens could still be extracted from the anus despite a CDmax exceeding 5 cm but was along the longitudinal axis of the rectum. Read More

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http://dx.doi.org/10.3760/cma.j.cn.441530-20191017-00453DOI Listing

Phase I/II Trial of Immunotherapy With Durvalumab and Tremelimumab With Continuous or Intermittent MEK Inhibitor Selumetinib in NSCLC: Early Trial Report.

Clin Lung Cancer 2020 Mar 4. Epub 2020 Mar 4.

Department of Thoracic/Head and Neck Medical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX; Department of Molecular and Cellular Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX. Electronic address:

Current strategies to improve clinical outcomes in v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog-mutant non-small-cell lung cancer (NSCLC) patients include mitogen-activated protein kinase kinase 1 inhibitor and programmed death (PD) 1 (PD-1)/PD ligand 1 (PD-L1) immune checkpoint blockade combinations. Experience from treatment of melanoma suggests that anti-cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and anti-PD-1/PD-L1 combinations improve outcomes, but similar benefits remain to be seen for treatment of NSCLC. This report describes a single center, investigator-initiated phase I/II clinical trial to compare 2 combination schedules of intermittent or continuous selumetinib (AZD6244, ARRY-142886), tremelimumab (anti-CTLA-4), and durvalumab (anti-PD-L1) treatment with historical controls in patients with previously treated, unresectable NSCLC. Read More

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http://dx.doi.org/10.1016/j.cllc.2020.02.019DOI Listing

Cytological diagnosis of a rare synchronous non-small cell lung cancer (NSCLC) metastatic to the thyroid gland.

Cytopathology 2020 Apr 14. Epub 2020 Apr 14.

Operative Unit of Pathologic Anatomy, Azienda USL della Romagna, Infermi Hospital of Rimini, Rimini, Italy.

Secondary neoplasms of the thyroid gland are quite uncommon with an estimated incidence rate of 0.1-3% , representing either distant metastases or direct extension of tumors from adjacent anatomic structures. Metastases of primary lung cancers to the thyroid are even more unusual but the aggressive nature of lung malignancies often induces to palliative treatment, reasonably underestimating its incidence. Read More

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http://dx.doi.org/10.1111/cyt.12832DOI Listing

Hazards of Recurrence, Second Primary, or Other Tumor at Ten Years After Surgery for Non-Small-Cell Lung Cancer.

Clin Lung Cancer 2020 Feb 26. Epub 2020 Feb 26.

Division of Thoracic Surgery and Hyperbaric Surgery, Department of Surgery, Medical University of Graz, Graz, Austria.

Introduction: Better treatment options entail the risk of multiple tumors in a patient's lifetime. We studied the incidence, risk factors, and prognostic impact of second primaries and other malignancies in patients with operated non-small-cell lung cancer (NSCLC).

Patients And Methods: We retrospectively analyzed 342 consecutive patients with curatively resected NSCLC between 2003 and 2007. Read More

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http://dx.doi.org/10.1016/j.cllc.2020.02.011DOI Listing
February 2020

Inhibition of ALAS1 activity exerts anti-tumour effects on colorectal cancer .

Saudi J Gastroenterol 2020 May-Jun;26(3):144-152

Department of General Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, P. R. China.

Background/aims: Colorectal cancer (CRC) is the third most common malignant tumour worldwide and the second leading cause of cancer-related deaths. Commonly, 5'-aminolevulinic acid synthase1 (ALAS1) is the rate-limiting enzyme for haem biosynthesis. Recent studies have shown that ALAS1 is involved in a number of cellular functions and has significant effects on non-small cell lung cancer (NSCLC). Read More

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http://dx.doi.org/10.4103/sjg.SJG_477_19DOI Listing

Pulmonary metastasis: very late relapse of testicular embryonal carcinoma.

Monaldi Arch Chest Dis 2020 Apr 8;90(1). Epub 2020 Apr 8.

Department of Translational Medical Sciences, University of Campania "Luigi Vanvitelli", Naples.

Testicular carcinoma recurrences represent a rare finding (1-6% in non-seminomatous germ cell tumours). However, cases of recurrence have been described many years later. We report a case of late recurrence of embryonic testicular carcinoma, after 26 years, with pulmonary metastases. Read More

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http://dx.doi.org/10.4081/monaldi.2020.1206DOI Listing

Flipping the Molecular Switch: Influence of Perlecan and Its Modifiers in the Tumor Microenvironment.

Adv Exp Med Biol 2020 ;1245:133-146

Department of Diagnostic and Biomedical Sciences, School of Dentistry, The University of Texas Health Science Center at Houston, Houston, TX, USA.

The tumor microenvironment (TME) is rich in matrix components, growth factors, cytokines, and enzymatic modifiers that respond to changing conditions, to alter the fundamental properties of the tumor bed. Perlecan/HSPG2, a large, multi-domain heparan sulfate proteoglycan, is concentrated in the reactive stroma that surrounds tumors. Depending on its state in the TME, perlecan can either prevent or promote the progression of cancers to metastatic disease. Read More

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http://dx.doi.org/10.1007/978-3-030-40146-7_6DOI Listing

A novel mutation of the folliculin gene causing Birt-Hogg-Dubé syndrome as rare cause for secondary pneumothorax.

Oxf Med Case Reports 2020 Mar 30;2020(3):omaa016. Epub 2020 Mar 30.

Division of General and Thoracic Surgery, University Hospital Krems, Karl Landsteiner University of Health Sciences, Krems an der Donau, Austria.

The Birt-Hogg-Dubé syndrome is an orphan genetic disease characterized by the development of renal neoplasms, fibrofolliculomas, pulmonary cysts and spontaneous pneumothoraces. Here, we report on the case of a 21-year-old man presenting with a primary event of a persistent spontaneous pneumothorax. Computed tomography images and a positive family history for pneumothoraces led to the suspicion of Birt-Hogg-Dubé syndrome. Read More

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http://dx.doi.org/10.1093/omcr/omaa016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7104189PMC

[Synchronous primary double: condrosarcoma and sarcoma high grade fusocelular associated with Maffucci syndrome].

Acta Ortop Mex 2019 Sep-Oct;33(5):325-328

Departamento de Piel y Partes Blandas del Instituto Nacional de Cancerología. Secretaría de Salud. Ciudad de México. México.

Maffucci syndrome is characterized by the presence of multiple enchondromes and hemangiomas that can affect soft tissues and other organs. The risk of malignant transformation of lesions is 100% during the life of the individual, with chondrosarcoma being the most frequently associated malignant tumor. We present the case of a 44-year-old man diagnosed with Maffucci syndrome who developed a synchronous double primary: chondrosarcoma and high-grade multicenter fusocellular sarcoma of scapular and tricipital region, was treated with disarticulation interscapule-thoracic, presented accelerated progression and lung disease. Read More

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Postoperative administration of ketorolac averts morphine-induced angiogenesis and metastasis in triple-negative breast cancer.

Life Sci 2020 Jun 31;251:117604. Epub 2020 Mar 31.

Department of Anesthesiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 510120 Guangzhou, China; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China. Electronic address:

Aims: Opioids (i.e. morphine) were found to induce triple negative breast cancer (TNBC) metastasis while nonsteroidal anti-inflammatory drugs (i. Read More

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http://dx.doi.org/10.1016/j.lfs.2020.117604DOI Listing

Src-family kinase inhibitors block early steps of caveolin-1-enhanced lung metastasis by melanoma cells.

Biochem Pharmacol 2020 Mar 30;177:113941. Epub 2020 Mar 30.

Cell Communication Laboratory, Center for Studies on Exercise, Metabolism and Cancer (CEMC), Institute of Biomedical Sciences (ICBM), Faculty of Medicine, Universidad de Chile, Santiago, Chile; Advanced Center for Chronic Diseases (ACCDiS), Santiago, Chile. Electronic address:

In advanced stages of cancer disease, caveolin-1 (CAV1) expression increases and correlates with increased migratory and invasive capacity of the respective tumor cells. Previous findings from our laboratory revealed that specific ECM-integrin interactions and tyrosine-14 phosphorylation of CAV1 are required for CAV1-enhanced melanoma cell migration, invasion and metastasis in vivo. In this context, CAV1 phosphorylation on tyrosine-14 mediated by non-receptor Src-family tyrosine kinases seems to be important; however, the effect of Src-family kinase inhibitors on CAV1-enhanced metastasis in vivo has not been studied. Read More

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http://dx.doi.org/10.1016/j.bcp.2020.113941DOI Listing

Antitumor Activity of Cabozantinib in Metastatic Adult Ewing Sarcoma: A Case Report.

Anticancer Res 2020 Apr;40(4):2265-2269

Department of Nuclear Medicine UZ Brussel, Brussels, Belgium.

A 49-year-old male with Ewing sarcoma and bone, pleural, lung and mediastinal lymph node metastasis was treated with cabozantinib after four lines of previous systemic treatments. He responded objectively and subjectively well for 8 months. In this heavily pretreated patient, the daily starting dose of 60 mg had to be reduced to 30 mg because of adverse events. Read More

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http://dx.doi.org/10.21873/anticanres.14190DOI Listing

Relative Change in S100 as a Biomarker of Survival in Patients With Metastatic Melanoma Treated With Pembrolizumab.

Anticancer Res 2020 Apr;40(4):2157-2163

Clinical Hospital Centre Zagreb, Department of Oncology, Zagreb, Croatia

Background/aim: There is a lack of quality biomarkers of survival for patients with metastatic melanoma treated with immunotherapy. Although the baseline level of S100 has prognostic value, its role during/after therapy in survival is unclear.

Patients And Methods: We evaluated patients with metastatic melanoma treated with pembrolizumab with the goal of analysing the relationship between a relative change in S100 level at 12 weeks of immunotherapy and survival. Read More

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http://dx.doi.org/10.21873/anticanres.14175DOI Listing