Int J Gynecol Pathol 2021 Nov 12. Epub 2021 Nov 12.
From the Department of Pathology, Royal Women's Hospital (K.L.T.); VCS Pathology, VCS Foundation (K.L.T., D.H.); Department of Biochemistry and Pharmacology, University of Melbourne (D.H.), Melbourne, Victoria, Australia; Department of Pathology, Brighton and Sussex University Hospitals NHS Trust, Brighton (S.R.); School of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth (S.R.); Department of Pathology, University of Malaya, Kuala Lumpur, Malaysia (D.H.); and Department of Pathology, Belfast Health and Social Care Trust, Belfast (W.G.M.), UK.
Seborrheic keratosis-like lesion (SKLL) is an extremely rare, morphologically distinct lesion occurring in the cervix and vagina that differs histologically from usual squamous intraepithelial lesions in these sites, by bearing close resemblance to cutaneous seborrheic keratosis and lacking koilocytosis. Like many vulvar seborrheic keratoses, which are associated with low-risk human papillomavirus (HPV), an association between SKLL and low-risk HPV is suggested based on the identification of HPV42, regarded as a low-risk genotype, in 4 of 8 reported cases. We report a further HPV42-associated SKLL of the cervix which differs from the previously reported cases by the presence of high-grade morphology and block-type p16 immunoreactivity. Read More