1,928 results match your criteria Seborrheic Keratosis

Human papillomavirus genotype distribution of genital keratotic lesions.

Australas J Dermatol 2022 May 11. Epub 2022 May 11.

Department of Dermatology, Kosin University College of Medicine, Busan, Korea.

Genital keratotic lesions include bowenoid papulosis (BP), which histologically resembles squamous cell carcinoma in situ containing high-risk HPV, condyloma acuminatum (CA) that is a genital wart containing mostly low-risk HPV, and genital seborrheic keratosis (GSK), which is a benign epidermal tumour lacking a clear etiologic relationship with HPV. This study compared HPV genotype distributions among BP, CA and GSK and revealed that BP and GSK were related to high-risk HPV whereas CA was related to low-risk HPV. It is plausible that GSK is a distinct epidermal tumour often related to high-risk HPV rather than merely a senescent form of CA considering the overall discrepancy in the frequency distribution of HPV genotypes along with histopathological differences, and the detection of high-risk HPV in GSK alerts physicians to consider more active treatment and continued follow-ups. Read More

View Article and Full-Text PDF

Expression of Retinal G Protein-Coupled Receptor, a Member of the Opsin Family, in Human Skin Cells and Its Mediation of the Cellular Functions of Keratinocytes.

Front Cell Dev Biol 2022 4;10:787730. Epub 2022 Apr 4.

Department of Dermatology, Affiliated Hospital of Guizhou Medical University, Guiyang, China.

Photoreceptive proteins play critical physiological roles in human skin cells. The retinal G protein-coupled receptor (RGR) is a photoisomerase in the human retina, but its expression and cellular functions in human skin cells have not been reported. We aimed to detect RGR expression in various skin cells and evaluate its regulation of the cellular functions of keratinocytes. Read More

View Article and Full-Text PDF

Darier disease successfully treated with a topical agent containing vitamin A (retinyl palmitate), vitamin E, and urea.

J Dermatol 2022 Apr 19. Epub 2022 Apr 19.

Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Darier disease (DD), also called keratosis follicularis, is an autosomal dominant hereditary keratinization disorder that manifests as keratotic papules with plaques in seborrheic areas. There are no validated curative treatments for DD, with the majority of cases treated symptomatically. We report the efficacy of a topical over-the-counter agent which contains retinyl palmitate, vitamin E, and urea for a patient with DD. Read More

View Article and Full-Text PDF

Studies on stratum corneum metabolism: function, molecular mechanism and influencing factors.

J Cosmet Dermatol 2022 Apr 18. Epub 2022 Apr 18.

Key Laboratory of Cosmetic of China National Light Industry, College of Chemistry and Materials Engineering, Beijing Technology and Business University, Beijing, China.

stratum corneum is located in the outermost layer of the skin and is the most important part of the skin barrier. stratum corneum mainly contains keratinocytes, lipid and desmosomes. Their normal metabolic process is closely related to the function of skin barrier. Read More

View Article and Full-Text PDF

Ungual seborrheic keratosis with longitudinal melanonychia: A case report.

J Dermatol 2022 Apr 15. Epub 2022 Apr 15.

Department of Dermatology, Graduate School of Medicine, Chiba University, Chiba, Japan.

In this paper, we report the case of a 71-year-old man with an 8-year history of melanonychia on the right little finger, who referred to our hospital because the color of pigmented area had gradually darkened and the width had expanded. Physical examination revealed longitudinal melanonychia with brown color (4 mm in width). Dermoscopic examination revealed multiple white round clods and splinter hemorrhages. Read More

View Article and Full-Text PDF

Longitudinal Erythro-Leukoxanthonychia Developing after PUVA Therapy.

Skin Appendage Disord 2022 Mar 28;8(2):165-168. Epub 2021 Sep 28.

Dermatology Department, Faculty of Medicine/Cairo University/Kasr Al-Ainy Hospital, Cairo, Egypt.

View Article and Full-Text PDF

Pigmented and polypoid tumor of the pubis.

Clin Case Rep 2022 Apr 5;10(4):e05692. Epub 2022 Apr 5.

Dermatology department Hedi Chaker University Hospital Sfax Tunisia.

Seborrheic keratosis is a common benign epidermal tumor occurring in patients aged over 50 years. It is located preferentially in the trunk, head and neck. The genital location is rare. Read More

View Article and Full-Text PDF

Partial spontaneous regression in two cases of seborrheic keratosis.

Int J Dermatol 2022 Apr 8. Epub 2022 Apr 8.

Department of Dermatology, Fukushima Medical University, Fukushima, Japan.

View Article and Full-Text PDF

Prevalence of Merkel Cell Polyomavirus in Normal and Lesional Skin: A Systematic Review and Meta-Analysis.

Front Oncol 2022 22;12:868781. Epub 2022 Mar 22.

Department of Burn and Plastic Surgery, West China Hospital, Sichuan University, Chengdu, China.

The prevalence of Merkel cell polyomavirus(MCPyV) in Merkel cell carcinoma(MCC) and non-MCC skin lesions and its possible role in the etiology of other skin diseases remain controversial. To systematically assess the association between MCPyV infection and MCC, non-MCC skin lesions, and normal skin. For this systematic review and meta-analysis, a comprehensive search for eligible studies was conducted using Medline Ovid, Pubmed, Web of Science, and the Cochrane CENTRAL databases until August 2021; references were searched to identify additional studies. Read More

View Article and Full-Text PDF

Classification of skin cancer using convolutional neural networks analysis of Raman spectra.

Comput Methods Programs Biomed 2022 Jun 21;219:106755. Epub 2022 Mar 21.

Department of Laser and Biotechnical Systems, Samara University, 34 Moskovskoe Shosse, Samara, 443086, Russian Federation.

Background And Objective: Skin cancer is the most common malignancy in whites accounting for about one third of all cancers diagnosed per year. Portable Raman spectroscopy setups for skin cancer "optical biopsy" are utilized to detect tumors based on their spectral features caused by the comparative presence of different chemical components. However, low signal-to-noise ratio in such systems may prevent accurate tumors classification. Read More

View Article and Full-Text PDF

Real-time high-resolution millimeter-wave imaging for in-vivo skin cancer diagnosis.

Sci Rep 2022 03 23;12(1):4971. Epub 2022 Mar 23.

Department of Electrical and Computer Engineering, Stevens Institute of Technology, 1 Castle Point Ter, Hoboken, NJ, 07030, USA.

High-resolution millimeter-wave imaging (HR-MMWI), with its high discrimination contrast and sufficient penetration depth, can potentially provide affordable tissue diagnostic information noninvasively. In this study, we evaluate the application of a real-time system of HR-MMWI for in-vivo skin cancer diagnosis. 136 benign and malignant skin lesions from 71 patients, including melanoma, basal cell carcinoma, squamous cell carcinoma, actinic keratosis, melanocytic nevi, angiokeratoma, dermatofibroma, solar lentigo, and seborrheic keratosis were measured. Read More

View Article and Full-Text PDF

Cutaneous manifestations of obesity in Turkish children: A comparative study.

Pediatr Dermatol 2022 Mar 14. Epub 2022 Mar 14.

Department of Dermatology, Aydın Adnan Menderes University Faculty of Medicine, Aydın, Turkey.

Background: Cutaneous changes in obese adults have been investigated in numerous studies, but this issue has not been adequately investigated in children.

Objectives: We aimed to determine the prevalence of skin manifestations in children with obesity by comparing them to normal-weight children.

Methods: A cross-sectional study was conducted between June 2017 and January 2019 in which 82 children with obesity and 86 normal-weight healthy control children were enrolled. Read More

View Article and Full-Text PDF

Clinical-Dermoscopic-Histopathological Correlations in Collision Skin Tumours.

Indian J Dermatol 2021 Nov-Dec;66(6):577-582

Department of Dermatovenereology, Faculty of Medicine and Teaching Hospital, Charles University, Pilsen, Czech Republic.

Objectives: Collision tumours are rare situations characterised by the coincidence of two different skin neoplasms in the same lesion.

Methods: We have analyzed 41 collision skin tumours from one department in the clinical-dermoscopic-histopathologic correlations.

Results: We present 41 collisions tumours. Read More

View Article and Full-Text PDF

Porokeratosis: a differential diagnosis to consider in benign lichenoid keratosis.

Int J Clin Exp Pathol 2022 15;15(2):56-62. Epub 2022 Feb 15.

Dermatology Division, Department of Anatomical Pathology, Pathlab 829 Cameron Road, Tauranga 3112, New Zealand.

Porokeratosis is a disorder of keratinization with many clinical variants. The histological hallmark feature of porokeratosis is a cornoid lamella. Other accompanying features include lichenoid inflammation, atrophy towards the centre of the lesion, dermal cytoid bodies, and adjacent lichenoid changes. Read More

View Article and Full-Text PDF
February 2022


Wiad Lek 2022 ;75(1 pt 2):172-175


Objective: The aim is to identify age, gender, clinical and morphological features of seborrheic keratosis.

Patients And Methods: Material and methods: The study used biopsy material from 196 patients with a clinical diagnosis of "Seborrheic keratosis". In all cases, when studying directions for pathohistological examination, the authors analyzed gender and age characteristics, as well as localization of seborrheic keratosis. Read More

View Article and Full-Text PDF
February 2022

Treatment of Seborrheic Keratosis by High Frequency Focused Ultrasound - An Early Experience with 11 Consecutive Cases.

Clin Cosmet Investig Dermatol 2022 28;15:145-156. Epub 2022 Jan 28.

TOOsonix A/S, Hoersholm, Denmark.

Purpose: High intensity focused ultrasound operating at 20 MHz has been demonstrated as a safe and efficient treatment modality for a range of dermatological indications. The method is potentially also applicable to removal of seborrheic keratosis.

Patients And Methods: A total of 54 seborrheic keratoses in 11 volunteer subjects (8 women and 3 men, average age 51. Read More

View Article and Full-Text PDF
January 2022

Dermoscopy in Primary Care.

Prim Care 2022 Mar 3;49(1):99-118. Epub 2022 Jan 3.

Department of Family and Community Medicine, Penn State Hersey Medical Center, 500 University Drive, Hersey, PA 17033, USA.

Dermoscopy is a noninvasive technique that allows in vivo magnification of the skin structures and helps in visualizing microscopic features that are imperceptible to the naked eye. Dermoscopy is not a substitute for biopsy and histopathologic evaluation, but is an important tool that can help increase diagnostic sensitivity and specificity of cutaneous lesions. Dermoscopy increases the diagnostic sensitivity compared with naked eye examination. Read More

View Article and Full-Text PDF

Reconstruction of the Defect at Temporal Hairline by a Scalp Keystone Island Flap: Clinical Experience on 14 Cases.

J Craniofac Surg 2022 Feb 4. Epub 2022 Feb 4.

Department of Plastic and Reconstruction, Shanghai Changhai Hospital Affiliated to Second Military Medical University Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Department of Plastic and Reconstruction, Shanghai Jiahui International Hospital, Department of General Surgery, Kongjiang Hospital of Yangpu District, Shanghai, People's Republic of China.

Background: The reconstructions of defects at the temporal hairline always require more complicated designs and higher surgical skills to acquire better aesthetic results. By taking advantage of the unique anatomy of the temporal region, the authors designed a scalp keystone island flap pedicled by superficial temporal fascia to repair defects on the temporal hairline.

Methods: The authors retrospectively analyzed the clinical data of 14 patients who had lesions adjacent to the temporal hairline between April 2018 and June 2020. Read More

View Article and Full-Text PDF
February 2022

Two-Stage Deep Neural Network Ensemble Learning for Melanoma Classification.

Front Bioeng Biotechnol 2021 18;9:758495. Epub 2022 Jan 18.

School of Computer Science and Engineering, Central South University, Changsha, China.

Melanoma is a skin disease with a high fatality rate. Early diagnosis of melanoma can effectively increase the survival rate of patients. There are three types of dermoscopy images, malignant melanoma, benign nevis, and seborrheic keratosis, so using dermoscopy images to classify melanoma is an indispensable task in diagnosis. Read More

View Article and Full-Text PDF
January 2022

Utility of 30% hydrogen peroxide in the treatment of seborrheic keratosis.

Int J Dermatol 2022 Jan 30. Epub 2022 Jan 30.

Department of Dermatology, Venereology and Leprosy, Kasturba Medical College, Manipal Academy of Higher Education (MAHE), Manipal, India.

Background: Hydrogen peroxide (H O ) has been used in medicine as an antiseptic, but at a higher concentration of 40%, it is used as a chemical cauterant for seborrheic keratoses (SKs). Its action and hence utility at 30% is unexplored. It can serve as a relatively inexpensive modality of treatment for SKs. Read More

View Article and Full-Text PDF
January 2022

HPV42-associated Seborrhoeic Keratosis-like Lesion of the Cervix: First Reported Case With High-grade Morphology.

Int J Gynecol Pathol 2021 Nov 12. Epub 2021 Nov 12.

From the Department of Pathology, Royal Women's Hospital (K.L.T.); VCS Pathology, VCS Foundation (K.L.T., D.H.); Department of Biochemistry and Pharmacology, University of Melbourne (D.H.), Melbourne, Victoria, Australia; Department of Pathology, Brighton and Sussex University Hospitals NHS Trust, Brighton (S.R.); School of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth (S.R.); Department of Pathology, University of Malaya, Kuala Lumpur, Malaysia (D.H.); and Department of Pathology, Belfast Health and Social Care Trust, Belfast (W.G.M.), UK.

Seborrheic keratosis-like lesion (SKLL) is an extremely rare, morphologically distinct lesion occurring in the cervix and vagina that differs histologically from usual squamous intraepithelial lesions in these sites, by bearing close resemblance to cutaneous seborrheic keratosis and lacking koilocytosis. Like many vulvar seborrheic keratoses, which are associated with low-risk human papillomavirus (HPV), an association between SKLL and low-risk HPV is suggested based on the identification of HPV42, regarded as a low-risk genotype, in 4 of 8 reported cases. We report a further HPV42-associated SKLL of the cervix which differs from the previously reported cases by the presence of high-grade morphology and block-type p16 immunoreactivity. Read More

View Article and Full-Text PDF
November 2021

Relationship between α-genus human papillomavirus and non-genital seborrheic keratosis: Report of new cases and updated review.

J Cosmet Dermatol 2022 Jan 23. Epub 2022 Jan 23.

The Department of Dermatology and Allergology, University Hospital of Munich LMU, Munich, Germany.

Background: Seborrheic keratoses (SK) are the most common acquired benign tumor that affects middle-aged or older adults with great cosmetic concern. Clinical and histopathological similarities of SK and common warts have been addressed by investigating the possible presence of human papillomavirus (HPV) DNA in SK. Previous studies suggested the association between α-genus HPV and SK located on genital skin, whereas the causal relationship between α-HPV and non-genital SK remains controversial. Read More

View Article and Full-Text PDF
January 2022

Preliminary Clinical Experience with a Novel Optical-Ultrasound Imaging Device on Various Skin Lesions.

Diagnostics (Basel) 2022 Jan 15;12(1). Epub 2022 Jan 15.

Dermus Ltd., Sopron út 64, 1116 Budapest, Hungary.

A compact handheld skin ultrasound imaging device has been developed that uses co-registered optical and ultrasound imaging to provide diagnostic information about the full skin depth. The aim of the current work is to present the preliminary clinical results of this device. Using additional photographic, dermoscopic and ultrasonic images as reference, the images from the device were assessed in terms of the detectability of the main skin layer boundaries and characteristic image features. Read More

View Article and Full-Text PDF
January 2022

Seasonal and gender variation in skin disease: A cross-sectional study of 3120 patients at Razi hospital.

Int J Womens Dermatol 2021 Dec 6;7(5Part B):799-802. Epub 2021 Oct 6.

Department of Dermatology, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran.

We aimed to determine the prevalence of different skin diseases and their seasonal variations at the Razi dermatology hospital from 2019 to 2020. In this cross-sectional study, we obtained data from the medical records of 3120 patients visiting the dermatology clinic of Razi hospital. The prevalence of skin diseases was evaluated using meteorologically defined seasons. Read More

View Article and Full-Text PDF
December 2021

Clonal Seborrheic keratosis: A Diagnostic Dilemma.

Dermatol Pract Concept 2021 Oct 1;11(4):e2021095. Epub 2021 Oct 1.

Sparkle Skin & Aesthetic Clinic, Vashi, Navi Mumbai, India.

View Article and Full-Text PDF
October 2021

Variability in the Histopathological Diagnosis of Non-Melanocytic Lesions Excised to Exclude Melanoma.

Dermatol Pract Concept 2021 Oct 1;11(4):e2021094. Epub 2021 Oct 1.

Future Industries Institute, University of South Australia, SA, Australia.

Introduction: The differential diagnosis of lesions excised to exclude melanoma include a variety of benign and malignant melanocytic and non-melanocytic lesions.

Objectives: We examined the variability between pathologists in diagnosing non-melanocytic lesions.

Methods: As part of a larger study prospectively examining the diagnosis of lesions excised to exclude melanoma in 198 patients at a primary care skin cancer clinic in Newcastle, Australia, we compared diagnosis made by 5 experienced dermatopathologists, of 44 non-melanocytic lesions in 44 patients aged 22-90. Read More

View Article and Full-Text PDF
October 2021

[The most common benign cutaneous neoplasms of the epidermis and appendages and their treatment].

Hautarzt 2022 Feb 5;73(2):94-103. Epub 2022 Jan 5.

Colentina Krankenhaus, Abt. Dermatology II, "Carol Davila"-Universität für Medizin und Pharmazie, Bukarest, Rumänien.

Benign cutaneous neoplasms are well defined histologically with absence of all of the following features: architectural disorder, necrosis, cytologic atypia, and atypical mitotic figures. The clinical appearance of any neoplasm is a very important diagnostic factor. The classification of the lesion determines the therapeutic options. Read More

View Article and Full-Text PDF
February 2022

Melanoma detection by skin self-examination targeting at-risk women: A randomized controlled trial with telemedicine support for concerning moles.

Prev Med Rep 2021 Dec 26;24:101532. Epub 2021 Aug 26.

Department of Preventive Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA.

Secondary melanoma prevention remains crucial to reduce morbidity and mortality for the 200,000 people in the United States estimated to develop melanoma in 2021. This 3-month randomized controlled trial of online skin self-examination (SSE) education among 1000 at-risk women who received care at Northwestern Medicine in Illinois sought to determine SSE initiation and monthly performance, SSE anxiety and confidence, and health care practitioner (HCP) visits for concerning moles. Positive responses to a personal history of sunburn, a personal or family history of skin cancer, and/or having 10 or more lifetime indoor tanning sessions identified and informed women of their increased risk of melanoma. Read More

View Article and Full-Text PDF
December 2021

Cutaneous Horn Revisited: A Woman With a Verruca Vulgaris-Associated Cornu Cutaneum.

Cureus 2021 Nov 26;13(11):e19925. Epub 2021 Nov 26.

Dermatology, University of California Davis Medical Center, Sacramento, USA.

A cutaneous horn, sometimes referred to as cornu cutaneum, is a projection arising on the skin due to an overgrowth of the epidermal stratum corneum. This lesion is a clinical presentation of an underlying skin tumor. A woman with a verruca vulgaris-associated cutaneous horn is described. Read More

View Article and Full-Text PDF
November 2021