1,839 results match your criteria Seborrheic Keratosis


An unusual case of co-localization of proliferating trichilemmal tumor and seborrheic keratosis.

Indian J Dermatol Venereol Leprol 2021 Apr 23:1-4. Epub 2021 Apr 23.

Department of Pathology, National Institute of Pathology (Indian Council of Medical Research), Safdarjung Hospital Campus, New Delhi, India.

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Umbilical Endometriosis Disguised by Seborrheic Keratosis on Punch Biopsy.

Am J Dermatopathol 2021 May 5. Epub 2021 May 5.

Department of Plastic Surgery, Copenhagen University Hospital, Herlev-Gentofte Hospital, Herlev, Denmark; and Department of Pathology, Copenhagen University Hospital, Herlev-Gentofte Hospital, Herlev, Denmark.

Abstract: Endometriosis is a benign condition of the female genital system, characterized by endometrial tissue external to the uterine cavity. Of all cases with endometriosis, the incidence of umbilical endometriosis is only 0.29%. Read More

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Seborrheic Keratosis With Sebaceous Differentiation, a Series of 8 Cases and Critical Review of the Literature.

Am J Dermatopathol 2021 May 5. Epub 2021 May 5.

Department of Dermatology and Allergy, University Hospital Munich (LMU), Germany; Institute of Pathology, Medical University Innsbruck, Innsbruck, Austria; Dermatohistology Laboratory, Offenbach on the Main, Germany; and Dermatopathology Unit, Department of Dermatology, Venereology and Allergology, Medical University Innsbruck, Innsbruck, Austria.

Abstract: Seborrheic keratosis with sebaceous differentiation (SKSD) can sometimes raise uncertainty, confuse with other even malignant entities, and lead to overestimation of this harmless variant. Retrospective analysis of the cases diagnosed as SKSD and a search of the pertaining literature were conducted. Eight cases of SKSD were found. Read More

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Differential Diagnosis and Management on Seborrheic Keratosis in Elderly Patients.

Clin Cosmet Investig Dermatol 2021 28;14:395-406. Epub 2021 Apr 28.

Dermatology Unit, University of Campania, Naples, Italy.

Seborrheic keratoses are exceedingly common in the elderly and usually are easy to diagnose and do not require treatment. However, given their great variety of clinical presentation, they may give rise to false-positive cases, meaning that they may at times mimic melanoma, squamous cell carcinoma and basal cell carcinoma. On the other hand, melanoma may mimic seborrheic keratosis, leading to incorrect patient management. Read More

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Adipophilin expression in skin lesions with clear cell histology.

J Clin Pathol 2021 May 5. Epub 2021 May 5.

Dermatology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China

Aims: Clear cells formed due to depositions of glycogen or lipids in the cytoplasm commonly occur in various tissues. Adipophilin (ADP), a lipid regulatory protein, is closely related to lipid droplets. This study aims to examine adipophilin expression in clear cells of various skin lesions. Read More

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Application of Cellular Resolution Full-Field Optical Coherence Tomography in vivo for the Diagnosis of Skin Tumours and Inflammatory Skin Diseases: A Pilot Study.

Dermatology 2021 May 4:1-11. Epub 2021 May 4.

Department of Dermatology, MacKay Memorial Hospital, Taipei, Taiwan.

Background: Optical coherence tomography (OCT) has been shown to provide non-invasive diagnosis of common skin neoplasms, especially basal cell carcinoma. OCT produces a cross-sectional view of the tissue, similar to a traditionally sectioned histopathological view, but the resolution of conventional OCT is low and thus limits clinical application.

Objectives: This study aimed to investigate the application ability of a full-field (FF)OCT system which was newly developed to scan the skin at the cellular level. Read More

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A Deep Learning Based Framework for Diagnosing Multiple Skin Diseases in a Clinical Environment.

Front Med (Lausanne) 2021 16;8:626369. Epub 2021 Apr 16.

Department of Dermatology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Numerous studies have attempted to apply artificial intelligence (AI) in the dermatological field, mainly on the classification and segmentation of various dermatoses. However, researches under real clinical settings are scarce. This study was aimed to construct a novel framework based on deep learning trained by a dataset that represented the real clinical environment in a tertiary class hospital in China, for better adaptation of the AI application in clinical practice among Asian patients. Read More

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Two Cases of Multiple Epidermolytic Acanthomas Mimicking Verruca Vulgaris.

Ann Dermatol 2020 Dec 11;32(6):512-515. Epub 2020 Nov 11.

Department of Dermatology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Epidermolytic acanthoma (EA) is a rare benign tumor, which usually appears as a solitary small papule. However, there are a few case reports of multiple EA, most of which occurs on the genital area. Cases of multiple EA may mimic verruca vulgaris, condyloma accuminatum, seborrheic keratosis, and bowenoid papulosis, and therefore, can be easily misdiagnosed. Read More

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December 2020

Dermatoses in the Elderly: Clinico-Demographic Profile of Patients Attending a Tertiary Care Centre.

Indian J Dermatol 2021 Jan-Feb;66(1):74-80

Department of Dermatology, All India Institute of Medical Sciences, Patna, Bihar, India.

Background: Elderly population is vulnerable to develop a multitude of dermatological diseases, owing to comorbidities and polypharmacies.

Objective: To know the prevalence of dermatological conditions in elderly patients attending outpatient department, determine the pattern and relative frequency of skin diseases, and find the relation with associated comorbidities.

Materials And Methods: We performed a cross-sectional study on 250 patients, aged ≥60 years. Read More

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Dermatoscopy and Reflective Confocal Microscopy for Facial Seborrheic Keratosis, Verruca Plana, and Nevus Pigmentosus.

J Coll Physicians Surg Pak 2021 Apr;30(4):450-454

Department of Dermatology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.

Objective: To describe the features of facial seborrheic keratosis, verruca plana, and nevus pigmentosus by dermatoscopy and reflective confocal microscope (RCM).

Study Design: Cross-sectional observational study.

Place And Duration Of Study: Dermatology Department of The Affiliated Hospital of Xuzhou Medical University from January 2017 to January 2019. Read More

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[Teledermatology in the Health Center West Area of Granada: From primary to specialized care].

Semergen 2021 Apr 13. Epub 2021 Apr 13.

Servicio de Dermatología, Hospital Universitario San Cecilio, Granada, España; Instituto biosanitario de Granada, Ibs, Granada, Spain. Electronic address:

Introduction: Teledermatology (TD) is a health tool based on the application of information and communication technologies (ICT) for the care of skin diseases at a distance, allowing a better connection between primary care professionals (PCP) and specialized care. The objective of this study was to analyze the characteristics of the teleconsultations made to our service in a period of 2years (January 1, 2018 to December 31, 2019).

Material And Methods: The data was obtained from a TD system with dermoscopy that allows teleconsultations to be carried out asynchronously. Read More

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Unusual Clinical Presentation of Giant Extragenital Condyloma.

Acta Dermatovenerol Croat 2020 Dec;28(7):240-241

Andrija Jovic, MD, Clinical Center of Nis, Clinic of Dermatovenereology , Bulevar Zorana Djindjica 48, Nis, Serbia;

Dear editor, Condylomata accuminatum (CA) is a human papillomavirus (HPV) related sexually transmitted infection (STI), clinically characterized by solitary or even clustered dark red or pink lesions solely affecting the anogenital area (1). CA involving the extragenital, non-mucosal skin has been sporadically reported (2-4). Diagnosis of CA is usually straightforward when the lesions are located on the anogenital area. Read More

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December 2020

Inflammatory seborrheic keratosis resolution after hyperbaric oxygen therapy: Case presentation and pathophysiology review.

Dermatol Reports 2021 Mar 18;13(1):8871. Epub 2021 Mar 18.

Sagol Center for Hyperbaric Medicine and Research, Shamir (Assaf Harofeh) Medical Center, Zerifin.

Seborrheic keratosis (SK) is a common epidermal tumor, consisting of a benign proliferation of immature keratinocytes. The natural history of SK is a slow progression over time and complete remission is not expected. The article presents the first case of a complete resolution of a large (2. Read More

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Epidermodysplasia verruciformis: report of two patients with autosomal dominant inheritance.

Dermatol Online J 2021 Feb 15;27(2). Epub 2021 Feb 15.

Department of Dermatology, University of São Paulo Medical School, São Paulo/SP.

Epidermodysplasia verruciformis is a rare genodermatosis associated with mutations in the EVER1/TMC6 and EVER2/TMC8 genes. The inheritance is considered to be autosomal recessive, but reports suggesting an autosomal dominant inheritance indicate disease genetic heterogeneity. Its onset occurs in early childhood and presents as a combination of pityriasis versicolor-like, flat wart-like and seborrheic keratosis-like lesions, with a potential for malignant transformation, mainly squamous cell carcinoma. Read More

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February 2021

The Role in Teledermoscopy of an Inexpensive and Easy-to-Use Smartphone Device for the Classification of Three Types of Skin Lesions Using Convolutional Neural Networks.

Diagnostics (Basel) 2021 Mar 5;11(3). Epub 2021 Mar 5.

Department of Health Science, University of Eastern Piedmont, Via Solaroli 17, 28100 Novara, Italy.

Background: The use of teledermatology has spread over the last years, especially during the recent SARS-Cov-2 pandemic. Teledermoscopy, an extension of teledermatology, consists of consulting dermoscopic images, also transmitted through smartphones, to remotely diagnose skin tumors or other dermatological diseases. The purpose of this work was to verify the diagnostic validity of images acquired with an inexpensive smartphone microscope (Nurugo), employing convolutional neural networks (CNN) to classify malignant melanoma (MM), melanocytic nevus (MN), and seborrheic keratosis (SK). Read More

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The Usefulness of Dermoscopy for the Recognition of Malignant Collision Tumors.

Dermatology 2021 Mar 31:1-8. Epub 2021 Mar 31.

Epidemiology Department, Hospital Sant Pau i Santa Tecla, Tarragona, Spain.

Background: Preoperative diagnosis of malignant collision tumors (MCT) is extremely difficult. The value of dermoscopy to improve the correct detection of these tumors has not been previously studied. This study aims to evaluate the diagnostic accuracy of MCT with and without dermoscopy and to describe the dermoscopic features of a large series of MCT. Read More

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Childhood-onset keratosis lichenoides chronica: A case report.

Clin Case Rep 2021 Mar 18;9(3):1462-1465. Epub 2021 Jan 18.

Skin Research Center Shahid Beheshti University of Medical Sciences Tehran Iran.

Keratosis lichenoides chronica (KLC) is a rare dermatosis which represents different clinical characteristics between adult- and pediatric-onset cases. We described a childhood case of KLC with features typical for adult-onset disease. Acitretin led to partial improvement of her skin, but not mucosal, lesions. Read More

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Large Seborrheic Keratosis of the Auricle Treated With Liquid Nitrogen Therapy.

Otol Neurotol 2021 Mar 23. Epub 2021 Mar 23.

Department of Otolaryngology-Head and Neck Surgery Department of Dermatology Department of Pathology, Kaohsiung Medical University Hospital, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.

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Mutational profile of skin lesions in hepatocellular carcinoma patients under tyrosine kinase inhibition: a repercussion of a wide-spectrum activity.

Oncotarget 2021 Mar 2;12(5):440-449. Epub 2021 Mar 2.

Barcelona Clinic Liver Cancer (BCLC) Group, Department of Pathology, Hospital Clínic de Barcelona, Universitat de Barcelona, Barcelona, Spain.

Background/aim: Dermatological adverse events (DAE) in hepatocellular carcinoma (HCC) patients treated with sorafenib predicts better outcome. Some turn into skin lesions (SL) requiring pathology examination. We describe incidence, characteristics and molecular profile of SL in HCC patients treated with sorafenib. Read More

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NUT Is a Specific Immunohistochemical Marker for the Diagnosis of YAP1-NUTM1-rearranged Cutaneous Poroid Neoplasms.

Am J Surg Pathol 2021 Feb 24. Epub 2021 Feb 24.

*CARADERM, French Network of Rare Cutaneous Cancer †Department of Pathology, Timone University Hospital ‡Aix Marseille University, INSERM, MMG, Marseille §Department of Pathology, Trousseau University Hospital, Tours ∥Department of Pathology, Cochin Hospital, AP-HP Paris University Center ¶University of Paris #Molecular Oncology Unit ∥∥Department of Pathology, Hospital Saint-Louis, AP-HP **INSERM, U976 HIPI, Paris ††Department of Dermatology, Lyon-Sud Hospital ‡‡Department of Biopathology, Léon Bérard Centre, Cypath, Lyon §§Department of Pathology, Bordeaux University Hospitals, Pessac ¶¶Department of Pathology, University Hospital of Poitiers ##LITEC EA 4331, B36, Poitiers, France.

YAP1-NUTM1 fusion transcripts have been recently reported in poroma and porocarcinoma. NUTM1 translocation can be screened by nuclear protein in testis (NUT) immunohistochemistry in various malignancies, but its diagnostic performance has not been thoroughly validated on a large cohort of cutaneous epithelial neoplasms. We have evaluated NUT immunohistochemical expression in a large cohort encompassing 835 cases of various cutaneous epidermal or adnexal epithelial neoplasms. Read More

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February 2021

An Update on the Cutaneous Manifestations of Darier Disease.

J Cutan Med Surg 2021 Mar 9:1203475421999331. Epub 2021 Mar 9.

26747 Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel.

Background: Knowledge about the clinical features of Darier disease, an orphan autosomal-dominant genetic disorder, is sparse and has been evaluated only in few studies.

Objectives: To investigate the clinical features of a large group of patients with Darier disease, and to explore for associations between disease characteristics and severity of the disease.

Methods: Seventy-six individuals with Darier disease were evaluated utilizing a structured questionnaire-based interview, a physical examination, and a retrospective assessment of their medical records. Read More

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[Hyperplasia-associated cutaneous paraneoplasia].

Hautarzt 2021 Apr 3;72(4):295-298. Epub 2021 Mar 3.

Klinik für Dermatologie und Allergologie, Hautklinik, Universitätsklinikum Aachen, Pauwelsstr. 30, 52074, Aachen, Deutschland.

Background: Hyperplasia-associated cutaneous paraneoplasia is an important differential diagnosis in everyday clinical practice. An early diagnosis of the underlying tumor disease can significantly improve the patient's prognosis.

Pathogenesis: Hyperplasia is probably mainly cytokine-mediated. Read More

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Usefulness of high-frequency ultrasound in differentiating basal cell carcinoma from common benign pigmented skin tumors.

Skin Res Technol 2021 Feb 27. Epub 2021 Feb 27.

Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Background: Basal cell carcinoma (BCC) is the most common cutaneous malignancy. Occasionally, it may have an appearance similar to that of some benign pigmented skin lesions. Therefore, additional information is needed to differentiate these lesions. Read More

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February 2021

Diagnosis of indolent systemic mastocytosis in a patient with "seborrheic keratosis".

Hematol Transfus Cell Ther 2021 Feb 12. Epub 2021 Feb 12.

Surrey Memorial Hospital, Surrey, BC, Canada.

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February 2021

Skin Cancer and Dermoscopy Training for Primary Care Physicians: A Pilot Study.

Dermatol Pract Concept 2021 Jan 29;11(1):e2021145. Epub 2021 Jan 29.

Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA.

Introduction: The primary objective of this study was to determine the diagnostic accuracy and effect of an educational training on skin cancer course and dermoscopy use among primary care physicians in rural areas of Colombia. The secondary objective was to assess the diagnostic accuracy of skin cancer diagnosis and detection rate after 3 months of the initial training.

Methods: Twenty-one primary care physicians from 6 rural areas of Colombia participated in a 2-day skin cancer and dermoscopy training, followed by a day-long hands-on session on dermoscopy at a free skin cancer screening event. Read More

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January 2021

Combining Reflective Confocal Microscopy and Dynamic Optical Coherence Tomography to Diagnose Melanoacanthoma: Case Report.

Am J Dermatopathol 2021 Feb 16. Epub 2021 Feb 16.

New York Institute of Technology College of Osteopathic Medicine, Old Westbury, NY; Department of Clinical Research, OptiSkin, New York, NY; Department of Dermatology, State University of New York Downstate, Brooklyn, NY; Department of Dermatology, Brooklyn Campus of the VA NY Harbor Healthcare System, Brooklyn, NY; Department of Pathology, State University of New York Downstate Medical Center, New York, NY; SkinMedical Research and Diagnostics, P.L.L.C., Dobbs Ferry, NY; and Faculty of Medicine and Health Sciences, University of Alcala de Henares, Madrid, Spain.

Abstract: Few reported cases discuss distinguishing between melanoma and melanoacanthoma, a seborrheic keratosis (SK) variant, using noninvasive imaging devices. We present a case of a 38-year-old man with Fitzpatrick skin type IV with an asymmetric black papule showing clinical and dermoscopic features of both melanoma and SK. Reflectance confocal microscopy (RCM) and dynamic optical coherence tomography (d-OCT) were used for further evaluation. Read More

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February 2021

In vivo diagnosis of skin cancer with a portable Raman spectroscopic device.

Exp Dermatol 2021 May 21;30(5):652-663. Epub 2021 Feb 21.

Department of Laser and Biotechnical Systems, Samara University, Samara, Russia.

In this study, we performed in vivo diagnosis of skin cancer based on implementation of a portable low-cost spectroscopy setup combining analysis of Raman and autofluorescence spectra in the near-infrared region (800-915 nm). We studied 617 cases of skin neoplasms (615 patients, 70 melanomas, 122 basal cell carcinomas, 12 squamous cell carcinomas and 413 benign tumors) in vivo with a portable setup. The studies considered the patients examined by GPs in local clinics and directed to a specialized Oncology Dispensary with suspected skin cancer. Read More

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Seborrheic keratosis in the auricle.

BMJ Case Rep 2021 Feb 5;14(2). Epub 2021 Feb 5.

Pathology, National Health Insurance Service Ilsan Hospital, Goyang, Korea (the Republic of).

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February 2021