1,627 results match your criteria Seborrheic Keratosis


A 14-year review of a UK teledermatology service: experience of over 40 000 teleconsultations.

Clin Exp Dermatol 2019 Feb 14. Epub 2019 Feb 14.

Medway NHS Foundation Trust, Gillingham, Kent, UK.

Background: There is a paucity of published evidence of established teledermatology (TD) services in the UK. An in-house TD service using store-and-forward technology was set up at a large regional dermatology department in 2004.

Aim: To review the TD service at our centre, including teleconsultation numbers, coding of diagnoses and patient outcomes. Read More

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http://dx.doi.org/10.1111/ced.13928DOI Listing
February 2019

Acanthosis nigricans, hypochondroplasia, and FGFR3 mutations: Findings with five new patients, and a review of the literature.

Pediatr Dermatol 2019 Feb 14. Epub 2019 Feb 14.

Department of Dermatology, CHU Nantes, Nantes, France.

Early development of extensive acanthosis nigricans (AN) is a key feature in some patients who have hypochondroplasia (HCH) in association with FGFR3 mutations. We here report regarding five new patients with HCH who exhibited AN, and we compare their characteristics to the eight patients previously described in the literature. In these patients, the AN lesions began in childhood, and they were extensive. Read More

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http://dx.doi.org/10.1111/pde.13748DOI Listing
February 2019

The sign of leser-trélat: think in the adenocarcinoma of the lung.

Pan Afr Med J 2018 10;30:270. Epub 2018 Aug 10.

Pulmonology Department, Moulay Youssef Hospital, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, Morocco.

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http://dx.doi.org/10.11604/pamj.2018.30.270.16337DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317404PMC

Endoscopic Submucosal Dissection of Seborrheic Keratosis-Like Lesion of the Esophagus: A New Entity?

Turk Patoloji Derg 2019 Jan 11. Epub 2019 Jan 11.

Department of Pathology, Izmir Katip Celebi University Ataturk Training and Research Hospital, IZMIR, TURKEY.

Seborrheic keratosis, one of the most common lesions of the epidermis, is rarely seen on mucosal surfaces. We report a case of a distinctive epithelial neoplasm of the esophagus showing close resemblance to seborrheic keratosis that was resected with endoscopic submucosal dissection. A 65-year-old patient's previous esophageal biopsy showed suspicious low grade dysplasia and the patient was referred for endoscopic submucosal dissection of a flat lesion in the mid-esophagus. Read More

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http://dx.doi.org/10.5146/tjpath.2018.01447DOI Listing
January 2019

Teaching Benign Skin Lesions as a Strategy to Improve the Triage Amalgamated Dermoscopic Algorithm (TADA).

J Am Board Fam Med 2019 Jan-Feb;32(1):96-102

From Maine Medical Center, Division of Dermatology, Portland, ME (EVS); Department of Family & Community Medicine (HTA) and Department of Dermatology (AG, MB), Penn State Milton S. Hershey Medical Center, Hershey, PA; Dermatology Department, Hospital Clínic de Barcelona, Universitat de Barcelona, Barcelona, Spain (OY); Dermatology Service, Memorial Sloan Kettering Cancer Center, New York, NY (OY, SWD, AAM).

Introduction: Dermoscopy aids family physicians (FPs) in skin cancer detection. The triage amalgamated dermoscopic algorithm (TADA) was created to simplify the dermoscopic evaluation of a skin growth. The purpose of this image-based study was to evaluate the effect of teaching the clinical and dermoscopic features of benign skin lesions on the diagnostic accuracy of skin cancer identification using TADA. Read More

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http://www.jabfm.org/lookup/doi/10.3122/jabfm.2019.01.180049
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http://dx.doi.org/10.3122/jabfm.2019.01.180049DOI Listing
February 2018
11 Reads

Seborrheic Keratoses - The Most Common Benign Skin Tumor of Humans. Clinical presentation and an update on pathogenesis and treatment options.

Authors:
Uwe Wollina

Open Access Maced J Med Sci 2018 Nov 23;6(11):2270-2275. Epub 2018 Nov 23.

Städtisches Klinikum Dresden, Department of Dermatology and Allergology, Dresden, Germany.

Seborrheic keratoses (SK) are the most common skin tumour of humanity. The incidence of this purely benign epithelial proliferation is increasing with age and exposure to ultraviolet light. It has a remarkable variability in its clinical presentation raising some differential diagnoses. Read More

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http://dx.doi.org/10.3889/oamjms.2018.460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290447PMC
November 2018
13 Reads

Reflectance confocal microscopy terminology glossary for non-melanocytic skin lesions: A systematic review.

J Am Acad Dermatol 2018 Dec 7. Epub 2018 Dec 7.

Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA. Electronic address:

Background: There is lack of uniformity in reflectance confocal microscopy (RCM) terminology for non-melanocytic lesions (NMLs).

Objective: To review published RCM terms for NMLs and identify likely-synonymous terms.

Methods: Systematic review of original research articles adhering to PRISMA guidelines was conducted until August 19, 2017. Read More

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http://dx.doi.org/10.1016/j.jaad.2018.12.007DOI Listing
December 2018
3 Reads

Treatment of benign pigmented lesions using a novel Dermal Cooling System.

Lasers Surg Med 2019 Jan 27;51(1):59-61. Epub 2018 Nov 27.

Department of Dermatology, University of California San Diego, La Jolla 92122, California.

Benign pigmented lesions are among the most common dermatologic diagnoses that patients seek treatments for. Treatment modalities range from cryotherapy to light and laser-based technologies. These treatments have been shown to be effective, yet may lead to dyschromia or significant downtime. Read More

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http://dx.doi.org/10.1002/lsm.23037DOI Listing
January 2019
1 Read

Fusing fine-tuned deep features for skin lesion classification.

Comput Med Imaging Graph 2019 Jan 3;71:19-29. Epub 2018 Nov 3.

School of Technology and Health, KTH Royal Institute of Technology, Stockholm, Sweden.

Malignant melanoma is one of the most aggressive forms of skin cancer. Early detection is important as it significantly improves survival rates. Consequently, accurate discrimination of malignant skin lesions from benign lesions such as seborrheic keratoses or benign nevi is crucial, while accurate computerised classification of skin lesion images is of great interest to support diagnosis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08956111183060
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http://dx.doi.org/10.1016/j.compmedimag.2018.10.007DOI Listing
January 2019
15 Reads

A retrospective study of 2228 cases with eyelid tumors.

Int J Ophthalmol 2018 18;11(11):1835-1841. Epub 2018 Nov 18.

Clinical College of Ophthalmology, Tianjin Medical University, Tianjin 300020, China.

Aim: To describe the histopathologic and clinical features of eyelid tumor cases from Tianjin Eye Hospital during 2002 to 2015.

Methods: In this retrospective study, a total of 2228 cases of eyelid tumors with pathologic diagnoses were enrolled. The eyelid tumors were classified into three groups according to tumor origin: epidermal, adnexal and miscellaneous, including melanocytic, neural and vascular lesions. Read More

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http://www.ijo.cn/gjyken/ch/reader/view_abstract.aspx?file_n
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http://dx.doi.org/10.18240/ijo.2018.11.16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232338PMC
November 2018
9 Reads

Skin Lesion Analysis By Multi-Target Deep Neural Networks.

Conf Proc IEEE Eng Med Biol Soc 2018 Jul;2018:1263-1266

Automatic skin lesion analysis involves two critical steps: lesion segmentation and lesion classification. In this work, we propose a novel multi-target deep convolutional neural network (DCNN) to simultaneously tackle the problem of segmentation and classification. Based on U-Net and GoogleNet, a single model is constructed with three different targets of both lesion segmentation and two independent binary lesion classifications (i. Read More

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http://dx.doi.org/10.1109/EMBC.2018.8512488DOI Listing

[Trained eye vs. gold standard].

Semergen 2018 Nov 8. Epub 2018 Nov 8.

Medicina Familiar y Comunitaria, Centro de Salud Ciudad Real I, Ciudad Real, España.

Objective: To determine the degree of correlation between the clinical diagnosis prior to the minor surgery process and its concordance with the results of histopathology report, as well as to determine the surgical data of little clinical importance compared to that which is really necessary and cost-effective.

Material And Method: A descriptive, observational, retrospective and transversal study was conducted of the Minor Surgery Activities of a clinic in the Ciudad Real Health Centre I.

Results: A total of 124 surgical specimens were sent for clinical diagnostic comparison, of which, the main clinical diagnoses were: intradermal melanocytic nevi (34. Read More

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http://dx.doi.org/10.1016/j.semerg.2018.09.001DOI Listing
November 2018
2 Reads

Hydrogen peroxide 40% (Eskata) for seborrheic keratoses.

Authors:

Med Lett Drugs Ther 2018 Sep;60(1556):157-158

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September 2018
1 Read

Anatomic Site-Specific Treatment Response With 40% Hydrogen Peroxide (w/w) Topical Formulation for Raised Seborrheic Keratoses: Pooled Analysis of Data from Two Phase 3 Studies.

J Drugs Dermatol 2018 Oct;17(10):1092-1098

Objective: Seborrheic keratoses (SKs) may present in any non-glabrous skin, but data are limited on the response to treatment as based on the SK location. We aimed to understand the relationship between SK location and clearance with up to 2 treatments of 40% (w/w) hydrogen peroxide topical solution (HP40).

Methods: We conducted a sub-analysis of data pooled from two randomized, double-blind, vehicle (VEH)-controlled clinical trials, including 937 patients, each with 4 target SKs (N=3,748 SKs), with at least 1 on the face and 1 on the trunk or extremities. Read More

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October 2018
9 Reads

Medical Image Classification Based on Deep Features Extracted by Deep Model and Statistic Feature Fusion with Multilayer Perceptron.

Comput Intell Neurosci 2018 12;2018:2061516. Epub 2018 Sep 12.

Department of Computer Science and Engineering, South China University of Technology, Guangzhou 510006, China.

Medical image classification is a key technique of Computer-Aided Diagnosis (CAD) systems. Traditional methods rely mainly on the shape, color, and/or texture features as well as their combinations, most of which are problem-specific and have shown to be complementary in medical images, which leads to a system that lacks the ability to make representations of high-level problem domain concepts and that has poor model generalization ability. Recent deep learning methods provide an effective way to construct an end-to-end model that can compute final classification labels with the raw pixels of medical images. Read More

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http://dx.doi.org/10.1155/2018/2061516DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157177PMC
December 2018

Giant perianal Seborrheic keratosis: A case report.

Int J Surg Case Rep 2018 12;51:296-301. Epub 2018 Sep 12.

Special Surgery Department, Faculty of Medicine, University of Jordan, P.O. Box 13857, Amman, 11942, Jordan. Electronic address:

Introduction: Seborrheic keratosis is one of the most common benign epidermal cutaneous lesions encountered by dermatologists and plastic surgeons in their daily practice.

Presentation Of The Case: A 66-year-old man was presented with a large verrucous mass on the sacrum and perianal area of 10 years duration. After the diagnosis of SK was confirmed, a complete excision of the lesion was done with coverage of the defect with a partial thikness skin graft, with a good outcome. Read More

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http://dx.doi.org/10.1016/j.ijscr.2018.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6148732PMC
September 2018
3 Reads

Managing Seborrheic Keratosis: Evolving Strategies and Optimal Therapeutic Outcomes.

J Drugs Dermatol 2018 Sep;17(9):933-940

Seborrheic keratosis (SK) is the most common skin tumor seen by dermatologists in everyday practice. Although the lesions are mostly benign, many patients still elect to have asymptomatic SK removed. The historical standards of treatment are cryosurgery and electrocautery, two surgical options that are effective at lesion removal but have high rates of postoperative adverse events such as treatment-site scarring and pigmentary alterations. Read More

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September 2018
5 Reads

Management of seborrhoeic keratosis and actinic keratosis with an erbium:YAG laser-experience with 547 patients.

Int J Oral Maxillofac Surg 2018 Sep 4. Epub 2018 Sep 4.

Oral and Maxillofacial Department, Poole Hospital NHS Foundation Trust, Poole, UK.

Seborrhoeic keratosis and actinic keratosis are common skin lesions, and the latter is a precursor for skin malignancy. The treatment regime can be lesion-directed or field-directed. Current lesion-directed treatments include cryotherapy, shave excision, and laser ablation. Read More

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http://dx.doi.org/10.1016/j.ijom.2018.08.008DOI Listing
September 2018
6 Reads

Clinical spectrum of cutaneous melanoma morphology.

J Am Acad Dermatol 2019 Jan 28;80(1):178-188.e3. Epub 2018 Aug 28.

Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; Department of Dermatology, Massachusetts General Hospital, Boston, Massachusetts. Electronic address:

Background: Melanoma can mimic other cutaneous lesions, but the full spectrum and prevalence of these morphologic variants remain largely unknown.

Objective: To classify nonacral cutaneous melanomas into distinct morphologic clusters and characterize clusters' clinicopathologic features.

Methods: All pathologic melanoma diagnoses (occurring during 2011-2016) were reviewed for routine prebiopsy digital photographs (n = 400). Read More

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http://dx.doi.org/10.1016/j.jaad.2018.08.028DOI Listing
January 2019
29 Reads
4.450 Impact Factor

Collision tumor: pigmented Bowen's disease and seborrheic keratosis.

An Bras Dermatol 2018 Sep-Oct;93(5):737-739

Oncological Dermatology Service, Instituto Nacional do Câncer, Rio de Janeiro (RJ), Brazil.

Bowen's disease is a type of squamous cell carcinoma in situ of the skin. The pigmented form is rare and represents less than 2% of cases. We report a case of a 74-year-old black man with a blackened and asymptomatic leg injury for about 6 months. Read More

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http://dx.doi.org/10.1590/abd1806-4841.20187117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6106659PMC
October 2018
15 Reads

Fogo selvagem: endemic pemphigus foliaceus.

An Bras Dermatol 2018 Sep-Oct;93(5):638-650

Dermatology Service, Hospital Maria Aparecida Pedrossian, Universidade Federal de Mato Grosso do Sul, Campo Grande (MS), Brazil.

Fogo selvagem or endemic pemphigus foliaceus is an autoimmune acantholytic anti-cadherin bullous disease that primarily affects seborrheic areas, which might disseminate. Brazil has the world's largest number of patients, mainly in the Central-West region, but the disease has also been reported in other South American countries. It affects young people and adults who have been exposed to rural areas, with occurrence of familial cases. Read More

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http://dx.doi.org/10.1590/abd1806-4841.20188235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6106655PMC
October 2018
18 Reads

Giant seborrheic keratosis of the genitalia with an unusual histopathological finding.

Indian J Sex Transm Dis AIDS 2017 Jul-Dec;38(2):176-179

Department of Skin and STD, Vinayaka Mission's Kirupananda Variyar Medical College and Hospital, Salem, Tamil Nadu, India.

Seborrheic keratosis (SK) of the external genitalia is a rare entity which can be easily misinterpreted as genital warts. Histopathology is a useful tool to make a diagnosis in such cases. We report a 62-year-old male who presented with multiple polypoidal lesions exclusively on the external genitalia. Read More

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http://dx.doi.org/10.4103/ijstd.IJSTD_95_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085941PMC
August 2018
4 Reads

Asymptomatic heterogeneously black-pigmented plaque in a 58-year-old man: an unusual presentation of a melanoma mimicker.

Dermatol Pract Concept 2018 Jul 31;8(3):224-226. Epub 2018 Jul 31.

Dermatology Department, Pontificia Universidad Católica de Chile, Santiago, Chile.

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http://dx.doi.org/10.5826/dpc.0803a14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092082PMC
July 2018
2 Reads

Challenging facial pigmented lesions: values and limits of confocal microscopy.

Dermatol Pract Concept 2018 Jul 31;8(3):188-190. Epub 2018 Jul 31.

Dermatology Unit, University of Campania Luigi Vanvitelli, Naples, Italy.

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http://dx.doi.org/10.5826/dpc.0803a08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092073PMC
July 2018
3 Reads

A prospective diagnostic study on povidone-iodine retention in lesions suspected to be squamous cell carcinoma or keratoacanthoma.

Australas J Dermatol 2018 Aug 15. Epub 2018 Aug 15.

Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.

Background And Objectives: While dermatoscopy improves diagnostic accuracy for raised nonpigmented lesions, those with white surface keratin can be problematical. We investigated whether retention of povidone-iodine by surface keratin provides a clue to benignity.

Methods: We performed a retrospective pilot study (n = 57) followed by a prospective study (n = 117) on raised nonpigmented lesions with white surface keratin. Read More

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http://dx.doi.org/10.1111/ajd.12897DOI Listing
August 2018
19 Reads

Skin lesion classification with ensembles of deep convolutional neural networks.

Authors:
Balazs Harangi

J Biomed Inform 2018 Oct 10;86:25-32. Epub 2018 Aug 10.

Faculty of Informatics, University of Debrecen, POB 400, 4002 Debrecen, Hungary. Electronic address:

Skin cancer is a major public health problem with over 123,000 newly diagnosed cases worldwide in every year. Melanoma is the deadliest form of skin cancer, responsible for over 9000 deaths in the United States each year. Thus, reliable automatic melanoma screening systems would provide a great help for clinicians to detect the malignant skin lesions as early as possible. Read More

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http://dx.doi.org/10.1016/j.jbi.2018.08.006DOI Listing
October 2018
3 Reads

The use of light-emitting diode imaging as exclusion criterion for melanoma diagnosis.

J Am Acad Dermatol 2019 Mar 3;80(3):e49-e50. Epub 2018 Aug 3.

São Carlos Institute of Physics, University of São Paulo, São Carlos, Brazil.

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http://dx.doi.org/10.1016/j.jaad.2018.07.031DOI Listing

Secondary Ossification Associated with Seborrheic Keratosis Adjacent to Basal Cell Carcinoma.

Indian J Dermatol 2018 Jul-Aug;63(4):357-359

Department of Dermatology, Fukushima Medical University, Fukushima, Japan. E-mail:

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http://dx.doi.org/10.4103/ijd.IJD_54_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6052741PMC
August 2018
4 Reads

Leser-Trélat Sign Presenting in a Patient with Relapsing Mycosis Fungoides.

Case Rep Oncol 2018 May-Aug;11(2):436-441. Epub 2018 Jun 29.

Pathology Department, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

The Leser-Trélat sign is a rare sign of some malignant tumors and is characterized by the sudden appearance of seborrheic keratosis in association with an underlying malignancy. We describe a 60-year-old Saudi man with mycosis fungoides (MF) who developed numerous, rapidly growing, seborrheic keratoses on his face and back. To the best of our knowledge, this is the first reported case of MF with the Leser-Trélat sign from Saudi Arabia. Read More

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http://dx.doi.org/10.1159/000490527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062719PMC
June 2018
3 Reads

Topical Application of 5-Fluorouracil Associated with Distant Seborrheic Dermatitis-like Eruption: Case Report and Review of Seborrheic Dermatitis Cutaneous Reactions after Systemic or Topical Treatment with 5-Fluorouracil.

Dermatol Ther (Heidelb) 2018 Sep 26;8(3):495-501. Epub 2018 Jul 26.

Department of Dermatology, University of California San Diego, La Jolla, CA, USA.

Introduction: 5-Fluorouracil is a fluoropyrimidine antineoplastic medication that is used to topically treat actinic keratoses. Although local adverse effects to the drug are common and anticipated, distant skin reactions are rare and unexpected. In this case report, we describe a patient who developed seborrheic dermatitis-like eruption at a distant site after topical application of 5-fluorouracil to his arms. Read More

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http://dx.doi.org/10.1007/s13555-018-0253-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109033PMC
September 2018
4 Reads

Immunohistochemical visualization of the signature of activated Hedgehog signaling pathway in cutaneous epithelial tumors.

J Dermatol 2018 Oct 23;45(10):1181-1186. Epub 2018 Jul 23.

Department of Pathology, Keio University School of Medicine, Tokyo, Japan.

Activation of the Hedgehog (HH) signaling pathway plays a critical role in the development of basal cell carcinoma (BCC). HH signaling activity is produced by nuclear translocation of transcription factors, glioma-associated oncogene homolog (GLI). Among three GLI subfamilies, GLI1 is the only full-length transcriptional activator, and its nuclear localization is recognized as a signature event in HH signaling activation. Read More

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http://dx.doi.org/10.1111/1346-8138.14543DOI Listing
October 2018
3 Reads

Video education to improve recognition of common benign and malignant cutaneous lesions and skin cancer prevention in the public.

Int J Womens Dermatol 2018 Jun 27;4(2):80-82. Epub 2017 Nov 27.

Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, IL.

Objective: Although dermatologists strive to provide patient education on sun protection and skin cancer, approximately 90% of Americans have limited health literacy skills. Little has been written about the means to best teach all levels of learners to recognize common benign and malignant skin lesions. Earlier work found that with advancing age, adults were less able to identify concerning lesions, thus underscoring the need for accessible education. Read More

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http://dx.doi.org/10.1016/j.ijwd.2017.10.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047166PMC
June 2018
1 Read

Sign of Leser-Trélat and Cutaneous T-Cell Lymphoma: A Rare Association.

Dermatopathology (Basel) 2018 Apr-Jun;5(2):69-73. Epub 2018 May 25.

Department of Dermatology, University Hospital of Geneva, Geneva, Switzerland.

Sign of Leser-Trélat is a rare paraneoplastic cutaneous manifestation, characterized by the sudden appearance and rapid increase in size and number of seborrheic keratoses, accompanied by pruritus. Edmund Leser and Ulysse Trélat described this sign in 1890. Since their first description, their conclusions have been considered controversial and some authors assert the absence of a causal link. Read More

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http://dx.doi.org/10.1159/000488982DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031949PMC
May 2018
11 Reads

Nivolumab induced inflammation of seborrheic keratoses: a novel cutaneous manifestation in a metastatic melanoma patient.

Melanoma Res 2018 10;28(5):475-477

Department of Dermatology, University Hospitals Cleveland Medical Center.

Immune checkpoint inhibitors targeting the programmed cell death (PD)-1 receptor have dramatically changed the landscape of metastatic melanoma treatment. Nevertheless, these immuno-modulatory agents have associated side effects, including dermatologic manifestations. To this end, we report a patient with metastatic melanoma that was treated with a PD-1 inhibitor, and subsequently developed inflammation of existing seborrheic keratosis lesions and new verrucous keratoses, a cutaneous side effect that has not been previously reported to our knowledge. Read More

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http://dx.doi.org/10.1097/CMR.0000000000000477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6110961PMC
October 2018
11 Reads

Artemether for topical use in patients with seborrhoeic keratosis.

Br J Dermatol 2018 Nov 17;179(5):1225-1226. Epub 2018 Sep 17.

EpiPharm AG, Binningen, Switzerland.

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http://dx.doi.org/10.1111/bjd.16930DOI Listing
November 2018

Store-and-forward teledermatology for the most common skin neoplasms in Ukraine.

Acta Dermatovenerol Alp Pannonica Adriat 2018 Jun;27(2):79-83

Kharkiv Medical Academy of Postgraduate Education, Kyiv, Ukraine.

Background: Among all malignancies in Ukraine in 2016, the group of non-melanoma skin cancers headed the list in men and made up 21.6%. This group was second in women and made up 17. Read More

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June 2018
25 Reads

Skin lesion segmentation in dermoscopy images via deep full resolution convolutional networks.

Comput Methods Programs Biomed 2018 Aug 19;162:221-231. Epub 2018 May 19.

Department of Biomedical Engineering, College of Electronics and Information, Kyung Hee University, Yongin, Republic of Korea. Electronic address:

Background And Objective: Automatic segmentation of skin lesions in dermoscopy images is still a challenging task due to the large shape variations and indistinct boundaries of the lesions. Accurate segmentation of skin lesions is a key prerequisite step for any computer-aided diagnostic system to recognize skin melanoma.

Methods: In this paper, we propose a novel segmentation methodology via full resolution convolutional networks (FrCN). Read More

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http://dx.doi.org/10.1016/j.cmpb.2018.05.027DOI Listing
August 2018
10 Reads

Borst-Jadassohn phenomenon arising from a seborrhoeic keratosis and its characteristic dermoscopic features.

Clin Exp Dermatol 2018 12 11;43(8):940-941. Epub 2018 Jun 11.

Department of Dermatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.

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http://dx.doi.org/10.1111/ced.13653DOI Listing
December 2018
1 Read

Safety and efficacy of hydrogen peroxide topical solution, 40% (w/w), in patients with seborrheic keratoses: Results from 2 identical, randomized, double-blind, placebo-controlled, phase 3 studies (A-101-SEBK-301/302).

J Am Acad Dermatol 2018 Nov 1;79(5):869-877. Epub 2018 Jun 1.

Aclaris Therapeutics Inc, Wayne, Pennsylvania.

Background: Approved topical treatments for seborrheic keratoses (SKs) are an unmet need.

Objective: To evaluate the safety and efficacy of 40% hydrogen peroxide topical solution (HP40) versus vehicle for the treatment of SKs (A-101-SEBK).

Methods: A total of 937 patients with 4 SKs each (≥1 lesion each on the face and on the trunk and/or an extremity) were randomized 1:1 to HP40 or vehicle. Read More

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http://dx.doi.org/10.1016/j.jaad.2018.05.044DOI Listing
November 2018
38 Reads

The challenge of diagnosing seborrheic keratosis by reflectance confocal microscopy.

Skin Res Technol 2018 Nov 24;24(4):663-666. Epub 2018 May 24.

Department of Dermatology, The Third Xiangya Hospital, Central South University, Changsha, China.

Background: Seborrheic keratosis (SK) is one of the most common skin tumors seen by dermatologists. It should be differentiated with many diseases, especially skin tumors. Reflectance confocal microscopy (RCM) has been applied for evaluation of SK. Read More

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http://dx.doi.org/10.1111/srt.12582DOI Listing
November 2018

[Vascularized tumor of the retroauricular skin].

Pathologe 2018 Jul;39(4):330-332

Dr. Senckenbergisches Institut für Pathologie, Universitätsklinikum Frankfurt, Theodor-Stern-Kai 6, 60590, Frankfurt am Main, Deutschland.

An 84-year-old female patient with loss of hearing and otorrhoea went to an otolaryngologist. On examination, a polypoid mass in the auditory canal and a retroauricular skin lesion, possibly seborrheic keratosis, were found. Only the skin was submitted for histological examination and showed a cutaneous highly vascular lesion with an associated "zellballen" of clear cells without atypia. Read More

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http://dx.doi.org/10.1007/s00292-018-0445-7DOI Listing

Role of In Vivo Reflectance Confocal Microscopy in the Analysis of Melanocytic Lesions.

Acta Dermatovenerol Croat 2018 Apr;26(1):64-67

Elena-Daniela Serban, MD, Department of Medical Oncology, University of Bologna, 40138 Bologna; Italy.

Worldwide melanoma incidence and mortality are increasing (1). Despite the ongoing research, advanced melanoma is still incurable; therefore, the most appropriate solution seems to be early detection combined with complete surgical excision (2). Since the diagnostic protocol of suspicious lesions includes a complete excision with safety margins (2), the problem of unnecessary scarring is significant. Read More

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April 2018
8 Reads

Study of hyperpigmentation in human skin disorder using different electron microscopy techniques.

Microsc Res Tech 2019 Jan 18;82(1):18-24. Epub 2018 May 18.

Department of Structure and Function of Neural Network, Korea Brain Research Institute, Daegu, 41068, Korea.

There is a global trend of increase in the demand for three-dimensional electron microscopy with high resolution. The ultrastructural change and related functional studies are necessary to investigate biological phenomena. In this study, currently available 3D reconstruction techniques of electron microscopes (serial block-face scanning electron microscopy and focused ion beam-scanning electron microscopy) were used to investigate hyperpigmentary disorders in human skin. Read More

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http://doi.wiley.com/10.1002/jemt.23052
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http://dx.doi.org/10.1002/jemt.23052DOI Listing
January 2019
7 Reads

High prevalence and correlates of human herpesvirus-6A in nevocytic nevus and seborrheic diseases: Implication from a pilot study of skin patient tissues in Shanghai.

J Med Virol 2018 Sep 25;90(9):1532-1540. Epub 2018 May 25.

MOE & MOH Key Laboratory of Medical Molecular Virology, Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Fudan University, Shanghai, China.

Skin disorders vary greatly in symptom and severity, and the causes of these disorders are largely unknown. Human herpesvirus (HHV) has been shown to cause many diseases. However, the prevalence and correlation of each HHV infection with different skin disorders remains obscure. Read More

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http://dx.doi.org/10.1002/jmv.25217DOI Listing
September 2018
5 Reads

Distinguishing between irritated seborrheic keratosis and squamous cell carcinoma in situ using BCL-2 and IMP3 immunohistochemistry.

J Cutan Pathol 2018 Aug 12;45(8):603-609. Epub 2018 Jun 12.

Department of Pathology, University of Massachusetts Medical School, UMass Memorial Medical Center, Worcester, Massachusetts.

Background: Distinguishing an irritated seborrheic keratosis (ISK) from a squamous cell carcinoma in situ (SCCIS) can occasionally be challenging, both histologically and clinically. The purpose of this study was to determine if an immunohistochemical profile of select markers can aid in differentiating these two entities.

Methods: We randomly selected and stained 103 ISK and 111 SCCIS for EGFR, IMP3, and BCL-2. Read More

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http://doi.wiley.com/10.1111/cup.13269
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http://dx.doi.org/10.1111/cup.13269DOI Listing
August 2018
11 Reads

Longitudinal subungual acanthoma: one denomination for various clinical presentations.

J Eur Acad Dermatol Venereol 2018 Sep 7;32(9):1608-1613. Epub 2018 Jun 7.

Dermatology Department, Cancer Institute, Gustave Roussy, Villejuif, France.

Background: Benign subungual proliferation of the distal nail matrix and bed such as longitudinal keratosis, seborrhoeic keratosis or onychocytic matricoma should belong to a single spectrum of diseases.

Objective: This article intends to demonstrate clinically and histologically the different facets of Nail unit longitudinal acanthoma.

Methods: We report three new cases that present as a longitudinal melanonychia with thickening of the nail plate in two of them and as leukoxanthonychia in the third one. Read More

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http://dx.doi.org/10.1111/jdv.15017DOI Listing
September 2018
3 Reads

Lentigo maligna: diagnosis and treatment.

G Ital Dermatol Venereol 2018 Apr 19. Epub 2018 Apr 19.

Institute of Dermatology, Catholic University of Rome, Fondazione Policlinico Universitario A. Gemelli, Rome, Italy.

Lentigo maligna (LM) is an in situ subtype of melanoma, clinically presenting as a pigmented, asymmetric macule that originates mostly on the head and neck and spreads slowly. The diagnosis may be challenging both for clinicians and pathologists. Dermatoscopy and reflectance confocal microscopy represent a useful tool in the differentiation of LM from other pigmented lesions, such as pigmented actinic keratosis, solar lentigines, seborrheic keratosis and lichen planus-like keratosis. Read More

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http://dx.doi.org/10.23736/S0392-0488.18.06003-0DOI Listing
April 2018
20 Reads

Differentiation of seborrheic keratosis from basal cell carcinoma, nevi and melanoma by RGB autofluorescence imaging.

Biomed Opt Express 2018 Apr 23;9(4):1852-1858. Epub 2018 Mar 23.

Institute of Atomic Physics and Spectroscopy, University of Latvia, Raina Blvd. 19, Riga LV-1586, Latvia.

A clinical trial on the autofluorescence imaging of skin lesions comprising 16 dermatologically confirmed pigmented nevi, 15 seborrheic keratosis, 2 dysplastic nevi, histologically confirmed 17 basal cell carcinomas and 1 melanoma was performed. The autofluorescence spatial properties of the skin lesions were acquired by smartphone RGB camera under 405 nm LED excitation. The diagnostic criterion is based on the calculation of the mean autofluorescence intensity of the examined lesion in the spectral range of 515 nm-700 nm. Read More

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http://dx.doi.org/10.1364/BOE.9.001852DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5905929PMC
April 2018
5 Reads

Dermatologic toxicity from novel therapy using antimicrobial peptide LL-37 in melanoma: A detailed examination of the clinicopathologic features.

J Cutan Pathol 2018 Jul 16;45(7):539-544. Epub 2018 May 16.

Department of Pathology, The University of Texas, MD Anderson Cancer Center, Houston, Texas.

LL-37 is a naturally occurring 37-amino-acid peptide that is part of the innate immune system in human skin. Preclinical studies have showed that intra-tumoral injections of LL-37 stimulate the innate immune system by activation of plasmacytoid dendritic cells, which mediate tumor destruction. LL-37 intra-tumoral injections have been utilized in a phase 1 clinical trial for melanoma patients with cutaneous metastases. Read More

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http://dx.doi.org/10.1111/cup.13262DOI Listing
July 2018
13 Reads
1.560 Impact Factor